Journal articles: 'Dopamine detection'

1

Cemgil Sultan, Sinan, Esma Sezer, Yudum Tepeli, and Ulku Anik. "Centri-voltammetric dopamine detection." RSC Adv. 4, no. 59 (2014): 31489–92. http://dx.doi.org/10.1039/c4ra04887c.

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Abu-Ali, Hisham, Cansu Ozkaya, Frank Davis, Nik Walch, and Alexei Nabok. "Electrochemical Aptasensor for Detection of Dopamine." Chemosensors 8, no. 2 (April 15, 2020): 28. http://dx.doi.org/10.3390/chemosensors8020028.

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This work presents a proof of concept of a novel, simple, and sensitive method of detection of dopamine, a neurotransmitter within the human brain. We propose a simple electrochemical method for the detection of dopamine using a dopamine-specific aptamer labeled with an electrochemically active ferrocene tag. Aptamers immobilized on the surface of gold screen-printed gold electrodes via thiol groups can change their secondary structure by wrapping around the target molecule. As a result, the ferrocene labels move closer to the electrode surface and subsequently increase the electron transfer. The cyclic voltammograms and impedance spectra recorded on electrodes in buffer solutions containing different concentration of dopamine showed, respectively, the increase in both the anodic and cathodic currents and decrease in the double layer resistance upon increasing the concentration of dopamine from 0.1 to 10 nM L−1. The high affinity of aptamer-dopamine binding (KD ≈ 5 nM) was found by the analysis of the binding kinetics. The occurrence of aptamer-dopamine binding was directly confirmed with spectroscopic ellipsometry measurements.

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MORA-FERRER, CARLOS, and VOLKER GANGLUFF. "D2-dopamine receptor blockade impairs motion detection in goldfish." Visual Neuroscience 17, no. 2 (March 2000): 177–86. http://dx.doi.org/10.1017/s0952523800171196.

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Under photopic illumination conditions, motion detection in goldfish is dominated by the long-wavelength-sensitive cone type (L-cone), and under scotopic conditions motion it is determined by rods (Schaerer & Neumeyer, 1996). The switch from rod-dominated to cone-dominated motion detection occurs during light adaptation. It has been suggested that dopamine acts as a neuronal light-adaptative signal. It is known that dopamine affects wavelength discrimination through D1-dopamine receptors (Mora-Ferrer & Neumeyer, 1996), and the dorsal light reflex through D1- and D2-dopamine receptors (Lin & Yazulla, 1994a). The purpose of this study was to determine whether dopamine influenced movement detection by goldfish, and if so, which dopamine receptor was involved. The D2-dopamine receptor antagonist sulpiride reduced the animal's sensitivity to the moving stimulus, whereas SCH 23390, a D1-dopamine receptor antagonist, did not have any effect. The effect of sulpiride is discussed in relation to known sulpiride effects on retinal neurons and the retinal pigment epithelium.

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Byington, Keith H. "Detection of dopamine-tissue adducts." Life Sciences 63, no. 1 (May 1998): 41–44. http://dx.doi.org/10.1016/s0024-3205(98)00234-3.

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Ortega, Fidel, and Elena Domínguez. "Selective catalytic detection of dopamine." Journal of Pharmaceutical and Biomedical Analysis 14, no. 8-10 (June 1996): 1157–62. http://dx.doi.org/10.1016/s0731-7085(96)01720-7.

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Azharudeen, A. Mohamed, Arpita Roy, R. Karthiga, S. Arun Prabhu, M. G. Prakash, A. Mohamed Ismail Badhusha, Huma Ali, Khadijah Mohammedsaleh Katubi, and Md Rabiul Islam. "Ultrasensitive and Selective Electrochemical Detection of Dopamine Based on CuO/PVA Nanocomposite-Modified GC Electrode." International Journal of Photoenergy 2022 (February 22, 2022): 1–9. http://dx.doi.org/10.1155/2022/8755464.

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At present, the determination of dopamine (DA) is enormously necessary for the human body. Since then, it has played a crucial role in the brain that affects mood, sleep, memory, learning, and concentration. Dopamine insufficiency is a threat to human health. Dopamine recognition is important to avoid this problem. Copper oxide (CuO) nanoparticles are one of the potentials which can be used in the detection of dopamine level in the sample. In this work, CuO was synthesized by a simple chemical precipitation technique and modified by polyvinyl alcohol (PVA) as a capping agent. The nanomaterials manufactured are used for the detection of dopamine in 0.1 M PBS medium at room temperature. The CuO/PVA-modified electrode shows better electrocatalytic activity than CuO/GCE (glassy carbon electrode). The constructed dopamine biosensor of copper oxide-PVA nanocomposites also has extraordinary selectivity, stability, sensitivity (183.12 μA mM-1 cm-2), and a minimum level detection limit of 0.017 μM, is inexpensive, and has minimal effort and rapid detection of dopamine.

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Mazurkiewicz, Wojciech, Artur Małolepszy, and Emilia Witkowska Nery. "Simultaneous Detection of Neurotransmitters Using Carbon Nanomaterials." ECS Meeting Abstracts MA2022-01, no. 53 (July 7, 2022): 2195. http://dx.doi.org/10.1149/ma2022-01532195mtgabs.

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Glassy carbon electrodes cleaned and electrochemically pretreated in PBS were compared to electrodes modified with carbon black, graphene oxide, and carbon dots in terms of possibility of detection of neurotransmiters. We provide systematic studies regarding the detection of five neurobiologically relevant species: dopamine, serotonin, epinephrine, norepinephrine, and 3,4-dihydroxyphenylacetic acid on those four types of electrodes. We also evaluated the possibility of simultaneous detection of dopamine and serotonin in the presence of high levels of uric and ascorbic acids. Dopamine and serotonin are easily detected at carbon surfaces but unfortunately at a similar potential. Polymerization of dopamine, resulting in sensitivity loss is another problem, when measurements are carried out in cell culture medium or even in model solutions at physiological pH. Norepinephrine and epinephrine are both products of dopamine metabolism. Their structure includes an o-hydroquinone, which upon oxidation and the transfer of two electrons transforms into o-quinone. Additional chemical reactions may occur resulting in e.g. cyclization of the chain containing the epinephrine’s amino group and subsequent additional quinone-hydroquinone reactions of this product. DOPAC is the product of dopamine deamination. In neutral pH, its oxidation is partially irreversible. As in case of dopamine, side reactions can lead to film formation on the electrode surface. It is considered an interferent in determining dopamine levels. Detection in the presence of acids has proven possible on all three types of electrode modifications, although with different resolution. We evaluated sensitivity in terms of current density per active area of the sensor. In this way graphene oxide exhibited the highest sensitivity towards all tested neurotransmitters, whereas chemically functionalized carbon nanodots significantly increased oxidation peaks’ resolution. A considerable shift of signals towards more negative potentials for epinephrine, norepinephrine, and 3,4-dihydroxyphenylacetic acid was observed for all modifications as compared with glassy carbon electrodes. Analytical parameters obtained for each type of modification are resumed in Tab. 1 (dopamine), Tab. 2 (serotonin) and Tab.3 (epinephrine and norepinephrine). As shown in this and other works electrode pretreatment has a huge impact on the recorded signal. Thus it is sometimes hard to compare materials tested by different research groups. The same procedure of electrochemical pretreatment was in this work applied to coated and uncoated glassy carbon electrodes. The pretreatment allowed for partial cleaning of polymerized dopamine. Authors would like to thank The National Centre for Research and Development, Poland, for funding under grants LIDER/38/0138/L-9/17/NCBR/2018 and LIDER/33/0117/L-9/17/NCBR/2018. EWN would like to also thank the Foundation for Polish Science (FNP), from which she was supported through START programme and National Science Centre Poland for the MINIATURA grant NCN 2017/01/X/ST4/00463 Figure 1

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Sobahi, Nebras, Mohd Imran, Mohammad Ehtisham Khan, Akbar Mohammad, Md Mottahir Alam, Taeho Yoon, Ibrahim M. Mehedi, Mohammad A. Hussain, Mohammed J. Abdulaal, and Ahmad A. Jiman. "Facile Fabrication of CuO Nanoparticles Embedded in N-Doped Carbon Nanostructure for Electrochemical Sensing of Dopamine." Bioinorganic Chemistry and Applications 2022 (October 14, 2022): 1–9. http://dx.doi.org/10.1155/2022/6482133.

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In the present study, a highly selective and sensitive electrochemical sensing platform for the detection of dopamine was developed with CuO nanoparticles embedded in N-doped carbon nanostructure (CuO@NDC). The successfully fabricated nanostructures were characterized by standard instrumentation techniques. The fabricated CuO@NDC nanostructures were used for the development of dopamine electrochemical sensor. The reaction mechanism of a dopamine on the electrode surface is a three-electron three-proton process. The proposed sensor’s performance was shown to be superior to several recently reported investigations. Under optimized conditions, the linear equation for detecting dopamine by differential pulse voltammetry is Ipa (μA) = 0.07701 c (μM) − 0.1232 (R2 = 0.996), and the linear range is 5-75 μM. The limit of detection (LOD) and sensitivity were calculated as 0.868 μM and 421.1 μA/μM, respectively. The sensor has simple preparation, low cost, high sensitivity, good stability, and good reproducibility.

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Fouad, Dina. "Development of a New Immunosensor for the Detection of Dopamine." Zeitschrift für Naturforschung C 62, no. 7-8 (August 1, 2007): 613–18. http://dx.doi.org/10.1515/znc-2007-7-826.

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Graphite immunoelectrodes as immunosensors using indirect immobilization of a hapten were investigated for their applicability to detect dopamine hydrochloride at low levels. Conditions were optimized to achieve the highest sensitivity using the indirect immobilization of dopamine hydrochloride through a polymerized glutaraldehyde network on microtiter plates using ELISA technique. The conditions were later transferred to the graphite rods (ø 0.8 m × 20 mm) and a comparison between the two different sensitivities (IC50 midpoint of test) was carried out. Graphite electrodes showed higher sensitivity towards dopamine than ELISA, since they were able to detect dopamine with a midpoint of test of 0.2 mmol/l while using ELISA they were able to detect dopamine hydrochloride at 2 mmol/l

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Santonocito, Rossella, Nunzio Tuccitto, Andrea Pappalardo, and Giuseppe Trusso Sfrazzetto. "Smartphone-Based Dopamine Detection by Fluorescent Supramolecular Sensor." Molecules 27, no. 21 (November 3, 2022): 7503. http://dx.doi.org/10.3390/molecules27217503.

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Supramolecular recognition of dopamine by two quinoxaline cavitands was studied in solution by fluorescence titrations, ESI-MS and ROESY measurements. In addition, the tetraquinoxaline cavitand was dropped onto a siloxane-based polymeric solid support, obtaining a sensor able to detect dopamine in a linear range of concentrations 10 Mm–100 pM, with a detection limit of 1 pM, much lower than the normal concentration values in the common human fluids (plasma, urine and saliva), by using a simple smartphone as detector. This sensor shows also good selectivity for dopamine respect to the other common analytes contained in a saliva sample and can be reused after acid–base cycles, paving the way for the realization of real practical sensor for human dopamine detection.

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Zablocka, Izabela, Monika Wysocka-Zolopa, and Krzysztof Winkler. "Electrochemical Detection of Dopamine at a Gold Electrode Modified with a Polypyrrole–Mesoporous Silica Molecular Sieves (MCM-48) Film." International Journal of Molecular Sciences 20, no. 1 (December 29, 2018): 111. http://dx.doi.org/10.3390/ijms20010111.

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A gold electrode modified with a polypyrrole–mesoporous silica molecular sieves (polypyrrole—MCM-48) nanostructure film was used for the electrochemical determination of small concentrations of dopamine (DA) by cyclic voltammetry and square-wave voltammetry techniques. This electrode showed good electrocatalytic activity for the oxidation of dopamine. The oxidation potential of dopamine was decreased significantly compared with that obtained at the bare gold electrode. The observed linear range for the determination of the dopamine concentration, without interferents through cyclic voltammetry measurements, was from 10 μM to 1.2 mM (R2 = 0.9989) for the gold electrode modified with the polypyrrole—MCM-48 nanostructure, with a detection limit of 2.5 μM. In the case of square-wave voltammetry, the linear range was 2–250 μM, with a correlation coefficient of 0.9996, and the detection limit was estimated to be 0.7 μM. The effects of interferents, such as ascorbic acid (AA) and uric acid (UA), on the electrochemical detection of dopamine were also examined. The modified electrode can successfully separate the oxidation potentials for ascorbic acid and dopamine, shifting the oxidation peak potential of ascorbic acid to a more positive potential, and significantly decreasing the peak current. The presence of ascorbic acid increased the sensitivity of dopamine determination at the modified electrode, and the detection limit was estimated to be 0.5 μM with 0.1 mM ascorbic acid to imitate physiological solutions. Additionally, studies showed that the presence of uric acid does not affect the electrochemical detection of dopamine. The modified electrode can be successfully applied for the quantitative analysis of dopamine both with and without interferents.

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Suzuki, Yoshio. "Development of Fluorescent Reagent Based on Ligand Exchange Reaction for the Highly Sensitive and Selective Detection of Dopamine in the Serum." Sensors 19, no. 18 (September 12, 2019): 3928. http://dx.doi.org/10.3390/s19183928.

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A new fluorescent probe (BDP-Fe2+) was developed for targeting dopamine, with a boron–dipyrromethenyl (BDP) group as the fluorophore and a Fe2+ complex as the ligand exchange site. The free form of BDP-Fe2+ in solution displayed weak fluorescence emission, while it showed strong fluorescence emission after interaction with dopamine due to the release of Fe2+ from BDP-Fe2+, confirming the binding of Fe2+ to dopamine. The increase in fluorescence intensity was concentration-dependent, and a good linear relationship was observed between the fluorescence intensity and dopamine concentration. The detection limit of dopamine by BDP-Fe2+ was 1.1 nM, indicating a 20-fold higher sensitivity than that of previously reported compounds. The reaction of BDP-Fe2+ with dopamine was not affected by the presence of foreign substances, allowing the highly selective detection of dopamine in the human serum sample. The results of this study indicate that the novel compound BDP-Fe2+ is a reliable fluorescent molecular probe for the detection of dopamine and can be widely employed in diverse scientific areas.

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Zhou, Jiawan, Wenyang Wang, Peng Yu, Erhu Xiong, Xiaohua Zhang, and Jinhua Chen. "A simple label-free electrochemical aptasensor for dopamine detection." RSC Adv. 4, no. 94 (2014): 52250–55. http://dx.doi.org/10.1039/c4ra08090d.

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Walsh, Ryan, Uyen Ho, Xiao Li Wang, and Maria C. DeRosa. "Selective dopamine detection using aptamer-functionalized glassy carbon electrodes." Canadian Journal of Chemistry 93, no. 5 (May 2015): 572–77. http://dx.doi.org/10.1139/cjc-2014-0444.

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The electrochemical detection of dopamine using glassy carbon electrodes suffers from a lack of selectivity toward the neurotransmitter, as interferences such as other catechol-containing neurochemicals and ascorbic acid can be oxidized at overlapping potentials. Several approaches have been employed to improve the selectivity of these electrodes towards dopamine including electrochemical pretreatment and organic monolayer depositions. Here, we characterize glassy carbon electrodes that were initially passivated through a trifluoromethylphenyl and nitrophenyl monolayer deposition and then functionalized with a specific DNA dopamine aptamer. Passivation with the mixed monolayer cuts off all signals from the redox-active neurochemicals. After functionalization with the DNA aptamer, the dopamine signal is restored and the electrodes are more responsive to dopamine than to any other related catechol-containing compounds or other common neurochemicals such as ascorbic acid. Our findings indicate that aptamer functionalization of glassy carbon electrodes may provide a viable approach for tuning the selectivity of electrochemical detection.

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Ho, Nguyen H. B., Dalton Lee Glasco, Rhys N. Sopp, and Jeffrey Gordon Bell. "Multiplexed Electrochemical Device for the Detection of Biomarkers of Parkinson’s Disease Using 3D Printing." ECS Transactions 109, no. 15 (September 30, 2022): 29–37. http://dx.doi.org/10.1149/10915.0029ecst.

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Acetylcholine and dopamine are two important neurotransmitters when diagnosing Parkinson’s disease, as the imbalance in acetylcholine and dopamine levels can lead to progressive neurological disorders. Currently, there are many detection methods for the individual neurotransmitters with their own advantages and disadvantages. Previously, dopamine has been highlighted as the most relevant biomarker for diagnosis, but interest in combined detection of acetylcholine and dopamine has increased. Since it has been discovered that both motor function and learning difficulties in Parkinsonism is dependent on dopamine and acetylcholine levels, determination of both biomarkers simultaneously has increased therapeutic relevance. This work reports the detection of acetylcholine and dopamine using 3D printed potentiometric and 3D printed voltammetric sensors, respectively. Linear responses were obtained over broad concentration ranges for both biomarkers with a fully 3D printed ion-selective membrane (acetylcholine) and conductive carbon electrodes (dopamine). This work describes a novel fabrication protocol for sensors that have the capability to detect both biomarkers simultaneously when integrated into a low-cost, reliable, and user-friendly multiplexed device, also fabricated with 3D printing technologies.

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Ouellette, Mathieu, Jessy Mathault, Shimwe Dominique Niyonambaza, Amine Miled, and Elodie Boisselier. "Electrochemical Detection of Dopamine Based on Functionalized Electrodes." Coatings 9, no. 8 (August 6, 2019): 496. http://dx.doi.org/10.3390/coatings9080496.

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The rapid electrochemical identification and quantification of neurotransmitters being a challenge in the ever-growing field of neuroelectronics, we aimed to facilitate the electrochemical selective detection of dopamine by functionalizing commercially available electrodes through the deposition of a thin film containing pre-formed gold nanoparticles. The influence of different parameters and experimental conditions, such as buffer solution, fiber material, concentration, and cyclic voltammetry (CV) cycle number, were tested during neurotransmitter detection. In each case, without drastically changing the outcome of the functionalization process, the selectivity towards dopamine was improved. The detected oxidation current for dopamine was increased by 92%, while ascorbic acid and serotonin oxidation currents were lowered by 66% under the best conditions. Moreover, dopamine sensing was successfully achieved in tandem with home-made triple electrodes and an in-house built potentiostat at a high scan rate mode.

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Pan, Lipeng, Mingye Zou, Fangxing Ma, Lingqing Kong, Changnan Zhang, Likun Yang, Anna Zhu, Feng Long, Xiang-Yang Liu, and Naibo Lin. "Fast dopamine detection based on evanescent wave detection platform." Analytica Chimica Acta 1191 (January 2022): 339312. http://dx.doi.org/10.1016/j.aca.2021.339312.

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Khan, Muhammad Salman, Afia Asif, Saed Khawaldeh, and Ahmet Tekin. "Dopamine detection using mercaptopropionic acid and cysteamine for electrodes surface modification." Journal of Electrical Bioimpedance 9, no. 1 (August 16, 2018): 3–9. http://dx.doi.org/10.2478/joeb-2018-0002.

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Abstract Gold electrodes are often not suitable for dopamine measurements as dopamine creates a non-conducting polymer layer on the surface of the electrodes, which leads to increased amount of electrode passivity with the gradual increase in voltammograms measurement. This work presents the impedance spectroscopy and cyclic-voltammetry comparative study for dopamine detection with two modifications for the surface of Au electrodes; cysteamine and mercaptopropionic acid for thermally bonded and ultrasonically welded microfluidic chips, respectively. The effects of optimized tubing selection, bonding techniques, and cleaning methods of the devices with KOH solution played crucial role for improvements in dopamine detection, which are observed in the results. Furthermore, comparison for the modification with unmodified chips, and finding the unknown concentration of dopamine solution using flow injection techniques, is also illustrated.

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Zhu, Zhen, Hsiang-Ning Luk, Yu-Shih Liu, Ren-Jang Wu, Ming-Hung Chung, and Xu-Jia Chang. "Preparation of Bimetallic Au-Pd/MWCNTs Electrode for Detection of Dopamine." Minerals 12, no. 9 (September 10, 2022): 1145. http://dx.doi.org/10.3390/min12091145.

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In this study, functionalized bimetallic Au-Pd on multi-walled carbon nanotubes (AuPd/MWCNT) are prepared and their application as electrochemical sensor materials for dopamine detection is explored. Furthermore, the as-prepared composite materials are identified using X-ray diffraction (XRD), scanning electron microscope (SEM), transmission electron microscope (TEM), and X-ray photoelectron spectrometer (XPS). In addition, the experimental results show that AuPd/MWCNT displayed excellent sensing properties to dopamine. Especially, 1% Pd-5% Au/MWCNT showed a wide detection range (0.98–200 μM) and a low detection limit of 0.058 μM for dopamine. The sensor also displayed properties such as repeatability, reproducibility, and stability, which can be ascribed to the large specific surface area and the synergistic effect of the bimetallic nanoparticles. Therefore, the prepared functionalized multi-walled carbon nanotubes have good application prospects in the field of dopamine detection.

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Martí, Mireia, Georgina Fabregat, Francesc Estrany, Carlos Alemán, and Elaine Armelin. "Nanostructured conducting polymer for dopamine detection." Journal of Materials Chemistry 20, no. 47 (2010): 10652. http://dx.doi.org/10.1039/c0jm01364a.

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Stewart, Alasdair J., Jodie Hendry, and Lynn Dennany. "Whole Blood Electrochemiluminescent Detection of Dopamine." Analytical Chemistry 87, no. 23 (November 13, 2015): 11847–53. http://dx.doi.org/10.1021/acs.analchem.5b03345.

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Manaf, Asrulnizam abd, Mahdiar Ghadiry, Reza Soltanian, Harith Ahmad, and C. K. Lai. "Picomole Dopamine Detection Using Optical Chips." Plasmonics 12, no. 5 (November 29, 2016): 1505–10. http://dx.doi.org/10.1007/s11468-016-0412-1.

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Wan, Yi, and Guiyou Zhu. "Dopamine-mediated immunoassay for bacteria detection." Analytical and Bioanalytical Chemistry 409, no. 26 (August 25, 2017): 6091–96. http://dx.doi.org/10.1007/s00216-017-0545-x.

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Detsri, Ekarat, Kanrayasiri Kamhom, and Chatsuda Detsri. "Microwave-Assisted Synthesis of Unmodified Gold Nanoparticles for Colorimetric Detection of Dopamine." Key Engineering Materials 730 (February 2017): 167–71. http://dx.doi.org/10.4028/www.scientific.net/kem.730.167.

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Unmodified gold nanoparticles (AuNPs) have been successfully synthesized by the chemical reduction of tetrachloride gold (III) ions ([AuCl4]-) in the presence of sodium citrate based on the rapid microwave−assisted approach. The diameter of the synthesized nanoparticles was found in the range of 16.50±2.75 nm. The AuNPs were characterized using UV−vis spectrophotometer, zeta potential analyzer and transmission electron microscope (TEM). The sodium citrate protected AuNPs were found to be selective and sensitive for the detection of dopamine. It was based on the aggregation change of the nanoparticles from random coil to hairpin structure upon the addition of dopamine concentration. The red shift of the plasmonic peak wavelength of AuNPs could be used for the detection of dopamine. The response to dopamine allows for a linear range from 10 to 125 mg⋅L-1 (R2 = 0.9804) with a limit of detection (LOD) at a signal to noise ratio of 3 of 12.85±1.38 mg⋅L-1. The colorimetric sensor was evaluated with 98.0−99.9% recovery of added dopamine in urine sample. The proposed sensor was successfully applied to the determination of dopamine in biological samples.

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Chandra, Umesh, B. E. Kumara Swamy, Ongera Gilbert, and B. S. Sherigara. "Voltammetric Detection of Dopamine in Presence of Ascorbic Acid and Uric Acid at Poly (Xylenol Orange) Film-Coated Graphite Pencil Electrode." International Journal of Electrochemistry 2011 (2011): 1–8. http://dx.doi.org/10.4061/2011/512692.

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Poly (xylenol orange) film-coated graphite pencil electrode was fabricated for the detection of dopamine in the presence of ascorbic acid and uric acid in phosphate buffer solution of pH 7. The redox peaks obtained at modified electrode shows a good enhancement. The scan rate effect was found to be a diffusion-controlled electrode process. The electrochemical oxidation of dopamine was depended on pH, and the limit of detection was found to be 9.1×10−8 M. The simultaneous study gave and excellent result with great potential difference between dopamine and other bioactive organic molecules by using both cyclic voltammetric and differential pulse voltammetric techniques. The present modified graphite electrode was applied to the detection of dopamine in the injection samples, and the recovery obtained was satisfactory.

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Liang, Yuanying, Ting Guo, Lei Zhou, Andreas Offenhäusser, and Dirk Mayer. "Label-Free Split Aptamer Sensor for Femtomolar Detection of Dopamine by Means of Flexible Organic Electrochemical Transistors." Materials 13, no. 11 (June 5, 2020): 2577. http://dx.doi.org/10.3390/ma13112577.

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The detection of chemical messenger molecules, such as neurotransmitters in nervous systems, demands high sensitivity to measure small variations, selectivity to eliminate interferences from analogues, and compliant devices to be minimally invasive to soft tissue. Here, an organic electrochemical transistor (OECT) embedded in a flexible polyimide substrate is utilized as transducer to realize a highly sensitive dopamine aptasensor. A split aptamer is tethered to a gold gate electrode and the analyte binding can be detected optionally either via an amperometric or a potentiometric transducer principle. The amperometric sensor can detect dopamine with a limit of detection of 1 μM, while the novel flexible OECT-based biosensor exhibits an ultralow detection limit down to the concentration of 0.5 fM, which is lower than all previously reported electrochemical sensors for dopamine detection. The low detection limit can be attributed to the intrinsic amplification properties of OECTs. Furthermore, a significant response to dopamine inputs among interfering analogues hallmarks the selective detection capabilities of this sensor. The high sensitivity and selectivity, as well as the flexible properties of the OECT-based aptasensor, are promising features for their integration in neuronal probes for the in vitro or in vivo detection of neurochemical signals.

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Aslıhan Avan, Asiye, and Hayati Filik. "Visible Light Detection of Dopamine Enhanced by Cloud Point Extraction." Current Pharmaceutical Analysis 15, no. 5 (May 23, 2019): 528–34. http://dx.doi.org/10.2174/1573412914666180427152544.

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Background: Monitoring of DA, in the presence of other chemical analogues such as epinephrine, norepinephrine, serotonin, ascorbic acid, uric acid, catechol, phenethylamine, tyramine, and tyrosine, is crucial in the diagnosis and mechanistic understanding of human neuropathology. Therefore, the determination of DA at trace levels has become a very important analytical task, as part of health safety and forensic analysis. Introduction: A cloud point extraction (CPE) process was developed for the isolation and detection of dopamine in food, urine, and pharmaceutical samples. Methods: In this procedure, dopamine was derivatized with o-phthalaldehyde (OPA) and sodium sulphite in aqueous solution. The isoindole derivative was synthesized by the reaction of OPA and sodium sulphite with the amino group of dopamine and the resulted isoindole derivatives were extracted by cloud point extraction. After extraction process, the concentration of enriched analyte was measured by UV-VIS spectrophotometry. The parameters affecting the CPE such as concentration of surfactant and electrolyte, equilibration temperature and time and pH of sample solution were investigated. Results: After optimization of the CPE conditions, the linear range of 8-80 µM (without extraction 100- 1000 µM) was established for dopamine with detection limit at 2.6 µM. Conclusion: The developed extraction procedure was applied to the quantification of dopamine in chocolate, urine, and pharmaceutical samples. The study ensures a promising strategy for the detection of dopamine in the presence of biological constituents, e.g. ascorbic acid, uric acid, and serotonin.

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Shen, Haishan, Byungkwon Jang, Jiyoung Park, Hyung-jin Mun, Hong-Baek Cho, and Yong-Ho Choa. "In Situ Synthesis of a Bi2Te3-Nanosheet/Reduced-Graphene-Oxide Nanocomposite for Non-Enzymatic Electrochemical Dopamine Sensing." Nanomaterials 12, no. 12 (June 10, 2022): 2009. http://dx.doi.org/10.3390/nano12122009.

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Dopamine is a neurotransmitter that helps cells to transmit pulsed chemicals. Therefore, dopamine detection is crucial from the viewpoint of human health. Dopamine determination is typically achieved via chromatography, fluorescence, electrochemiluminescence, colorimetry, and enzyme-linked methods. However, most of these methods employ specific biological enzymes or involve complex detection processes. Therefore, non-enzymatic electrochemical sensors are attracting attention owing to their high sensitivity, speed, and simplicity. In this study, a simple one-step fabrication of a Bi2Te3-nanosheet/reduced-graphene-oxide (BT/rGO) nanocomposite was achieved using a hydrothermal method to modify electrodes for electrochemical dopamine detection. The combination of the BT nanosheets with the rGO surface was investigated by X-ray diffraction, X-ray photoelectron spectroscopy, field-emission scanning electron microscopy, transmission electron microscopy, Raman spectroscopy, and Fourier-transform infrared spectroscopy. Electrochemical impedance spectroscopy, cyclic voltammetry, and differential pulse voltammetry were performed to analyze the electrochemical-dopamine-detection characteristics of the BT/rGO nanocomposite. The BT/rGO-modified electrode exhibited higher catalytic activity for electrocatalytic oxidation of 100 µM dopamine (94.91 µA, 0.24 V) than that of the BT-modified (4.55 µA, 0.26 V), rGO-modified (13.24 µA, 0.23 V), and bare glassy carbon electrode (2.86 µA, 0.35 V); this was attributed to the synergistic effect of the electron transfer promoted by the highly conductive rGO and the large specific surface area/high charge-carrier mobility of the two-dimensional BT nanosheets. The BT/rGO-modified electrode showed a detection limit of 0.06 µM for dopamine in a linear range of 10–1000 µM. Additionally, it exhibited satisfactory reproducibility, stability, selectivity, and acceptable recovery in real samples.

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Park, Seon Joo, Seung Hwan Lee, Heehong Yang, Chul Soon Park, Chang-Soo Lee, Oh Seok Kwon, Tai Hyun Park, and Jyongsik Jang. "Human Dopamine Receptor-Conjugated Multidimensional Conducting Polymer Nanofiber Membrane for Dopamine Detection." ACS Applied Materials & Interfaces 8, no. 42 (October 14, 2016): 28897–903. http://dx.doi.org/10.1021/acsami.6b10437.

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Wei, Xiao, Zhendong Zhang, and Zhenhong Wang. "A simple dopamine detection method based on fluorescence analysis and dopamine polymerization." Microchemical Journal 145 (March 2019): 55–58. http://dx.doi.org/10.1016/j.microc.2018.10.004.

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ARAVIND, S. S. JYOTHIRMAYEE, SATHISH KUMAR SRINIVASAN, and SUNDARA RAMAPRABHU. "Au/TiO2 NANOTUBES FOR SELECTIVE DETECTION OF DOPAMINE." International Journal of Nanoscience 10, no. 04n05 (August 2011): 1185–89. http://dx.doi.org/10.1142/s0219581x11008460.

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A novel biosensor for dopamine (DA) detection was fabricated using TiO2 nanotube and Au/TiO2 nanotube films on glassy carbon electrode (GCE). The Au/TiO2 nanotubes on electrode showed better electrocatalytic activity towards the detection of DA which was attributed to its excellent electron conductive network. The biosensor elicited sensitivity of 22 nA/μM with a linearity of detection localized in the concentration range from 5–120 μM with correlation coefficient of 0.99. The detection limit of DA for the Au/TiO2 nanotube biosensor was found to be ~3 μM (S/N = 3). In addition, the fabricated sensor showed good anti-interference capability towards biological compounds such as ascorbic acid and uric acid. In conclusion, Au/TiO2 nanotube biosensor exhibits excellent catalytic activity, selectivity and simplicity for the detection of dopamine.

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Jiang, Cui Feng, Neng Yue Gao, Qi Sheng Wu, Yu Sun, and Qing Hua Xu. "Two-Photon Sensing of Dopamine by Using Au Nanoparticles." Applied Mechanics and Materials 738-739 (March 2015): 31–37. http://dx.doi.org/10.4028/www.scientific.net/amm.738-739.31.

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In this paper, we demonstrated a gold nanoparticle based two-photon photoluminescence (TPPL) assay for the detection of dopamine with the detection limit of 0.3 μM. Protonated dopamine molecules can bind bidentately to surface of gold atoms through the catechol group. The adsorption of dopamine displaces the stabilizing agent of citrate groups, and neutralizes the charge of solution, resulting in non-cross linking aggregation of Au NPs. Aggregation of Au NPs could induce significantly enhanced TPPL. Thus, a simple TPPL assay was designed. We have shown that when Au NPs solution was mixed with dopamine, TPPL intensity increased by about 47 times. The mechanism of sensing assay has been discussed. In addition, the TPPL assay was highly selective to dopamine and it can distinguish from uric acid, ascorbic acid and metal ions.

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Ahmadov, Tevhide Ozkaya, Padmanabh Joshi, Jinnan Zhang, Keaton Nahan, Joseph A. Caruso, and Peng Zhang. "Paramagnetic relaxation based biosensor for selective dopamine detection." Chemical Communications 51, no. 57 (2015): 11425–28. http://dx.doi.org/10.1039/c5cc02732b.

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Camargo, Luan Pereira, Marcelo Rodrigues da Silva Pelissari, Paulo Rogério Catarini da Silva, Augusto Batagin-Neto, Roberta Antigo Medeiros, Marcos Antônio Dias, and Luiz Henrique Dall’Antonia. "Visible Light Photoelectrochemical Sensor for Dopamine: Determination Using Iron Vanadate Modified Electrode." Molecules 27, no. 19 (September 28, 2022): 6410. http://dx.doi.org/10.3390/molecules27196410.

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This study reports a facile approach for constructing low-cost and remarkable electroactivity iron vanadate (Fe-V-O) semiconductor material to be used as a photoelectrochemical sensor for dopamine detection. The structure and morphology of the iron vanadate obtained by the Successive Ionic Adsorption and Reaction process were critically characterized, and the photoelectrochemical characterization showed a high photoelectroactivity of the photoanode in visible light irradiation. Under best conditions, dopamine was detected by chronoamperometry at +0.35 V vs. Ag/AgCl, achieving two linear response ranges (between 1.21 and 30.32 μmol L−1, and between 30.32 and 72.77 μmol L−1). The limits of detection and quantification were 0.34 and 1.12 μmol L−1, respectively. Besides, the accuracy of the proposed electrode was assessed by determining dopamine in artificial cerebrospinal fluid, obtaining recovery values ranging from 98.7 to 102.4%. The selectivity was also evaluated by dopamine detection against several interferent species, demonstrating good precision and promising application for the proposed method. Furthermore, DFT-based electronic structure calculations were also conducted to help the interpretation. The dominant dopamine species were determined according to the experimental conditions, and their interaction with the iron vanadate photoanode was proposed. The improved light-induced DOP detection was likewise evaluated regarding the charge transfer process.

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Chen, Yi-Pin, Anisha Roy, Ping-Hsuan Wu, Shih-Yin Huang, and Siddheswar Maikap. "Dopamine-Sensing Characteristics and Mechanism by Using N2/O2 Annealing in Pt/Ti/n-Si Structure." Electronics 10, no. 24 (December 17, 2021): 3146. http://dx.doi.org/10.3390/electronics10243146.

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Dopamine detection by using N2/O2 annealing in a Pt/Ti/n-Si structure is investigated for the first time. To achieve repeatable and stable dopamine detection, a Pt membrane is annealed at elevated temperatures of 500 to 700 °C. N2/O2 gas ambient is used to optimize the membrane. The Pt membrane with thicknesses from 5 to 2 nm is optimized. Novel Pt/Ti/n-Si Schottky contact in a metal–electrolyte–membrane–silicon (MEMS) structure detects dopamine with a low concentration of 1 pM. The Pt membrane with N2 ambient annealing shows the lowest concentration of dopamine sensing with a small volume of 10 µL, acceptable stability, and repeatability. Scan rate-dependent dopamine concentration sensing is also investigated in the two-terminal measurement method. This study is useful for the early diagnosis of Parkinson’s disease in the near future.

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JIANG Li-ying, 姜利英, 杭欣欣 HANG Xin-xin, 张. 培. ZHANG Pei, 任林娇 REN Lin-jiao, and 王. 慰. WANG Wei. "Fluorescence-enhanced aptamer sensor for dopamine detection." Optics and Precision Engineering 27, no. 9 (2019): 1943–49. http://dx.doi.org/10.3788/ope.20192709.1943.

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Kishida, Kenneth T., Stefan G. Sandberg, Terry Lohrenz, Youssef G. Comair, Ignacio Sáez, Paul E. M. Phillips, and P. Read Montague. "Sub-Second Dopamine Detection in Human Striatum." PLoS ONE 6, no. 8 (August 4, 2011): e23291. http://dx.doi.org/10.1371/journal.pone.0023291.

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Olabode, Olaitan, Marko Kosunen, Vishnu Unnikrishnan, Tommi Palomaki, Tomi Laurila, Kari Halonen, and Jussi Ryynanen. "Time-Based Sensor Interface for Dopamine Detection." IEEE Transactions on Circuits and Systems I: Regular Papers 67, no. 10 (October 2020): 3284–96. http://dx.doi.org/10.1109/tcsi.2020.3008363.

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Lin, Jun, Bin Huang, Yanfeng Dai, Junchao Wei, and Yiwang Chen. "Chiral ZnO nanoparticles for detection of dopamine." Materials Science and Engineering: C 93 (December 2018): 739–45. http://dx.doi.org/10.1016/j.msec.2018.08.036.

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Wightman, R. Mark, Leslie J. May, and Adrian C. Michael. "Detection of dopamine dynamics in the brain." Analytical Chemistry 60, no. 13 (July 1988): 769A—779A. http://dx.doi.org/10.1021/ac00164a001.

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Wightman, R. Mark, Leslie J. May, and Adrian C. Michael. "Detection of Dopamine Dynamics in the Brain." Analytical Chemistry 60, no. 13 (July 1988): 769A—793A. http://dx.doi.org/10.1021/ac00164a718.

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Hu, Keke, Dengchao Wang, Min Zhou, Je Hyun Bae, Yun Yu, Huolin Xin, and Michael V. Mirkin. "Ultrasensitive Detection of Dopamine with Carbon Nanopipets." Analytical Chemistry 91, no. 20 (September 10, 2019): 12935–41. http://dx.doi.org/10.1021/acs.analchem.9b02994.

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Rees, Hillary R., Sean E. Anderson, Eve Privman, Haim H. Bau, and B. Jill Venton. "Carbon Nanopipette Electrodes for Dopamine Detection inDrosophila." Analytical Chemistry 87, no. 7 (March 9, 2015): 3849–55. http://dx.doi.org/10.1021/ac504596y.

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Lu, Guang, Guanhua Yu, Xia Kong, Yuxiang Chen, Dexin Yin, Wenxin Lu, and Qingyun Liu. "Porphyrin/MoS2 film for ultrasensitive dopamine detection." Inorganic Chemistry Communications 110 (December 2019): 107591. http://dx.doi.org/10.1016/j.inoche.2019.107591.

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Yang, Cheng, Keke Hu, Dengchao Wang, Yasmine Zubi, Scott T. Lee, Pumidech Puthongkham, Michael V. Mirkin, and B. Jill Venton. "Cavity Carbon-Nanopipette Electrodes for Dopamine Detection." Analytical Chemistry 91, no. 7 (February 27, 2019): 4618–24. http://dx.doi.org/10.1021/acs.analchem.8b05885.

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Lei, Yu, Derrick Butler, Michael C. Lucking, Fu Zhang, Tunan Xia, Kazunori Fujisawa, Tomotaroh Granzier-Nakajima, et al. "Single-atom doping of MoS2 with manganese enables ultrasensitive detection of dopamine: Experimental and computational approach." Science Advances 6, no. 32 (August 2020): eabc4250. http://dx.doi.org/10.1126/sciadv.abc4250.

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Two-dimensional transition metal dichalcogenides (TMDs) emerged as a promising platform to construct sensitive biosensors. We report an ultrasensitive electrochemical dopamine sensor based on manganese-doped MoS2 synthesized via a scalable two-step approach (with Mn ~2.15 atomic %). Selective dopamine detection is achieved with a detection limit of 50 pM in buffer solution, 5 nM in 10% serum, and 50 nM in artificial sweat. Density functional theory calculations and scanning transmission electron microscopy show that two types of Mn defects are dominant: Mn on top of a Mo atom (MntopMo) and Mn substituting a Mo atom (MnMo). At low dopamine concentrations, physisorption on MnMo dominates. At higher concentrations, dopamine chemisorbs on MntopMo, which is consistent with calculations of the dopamine binding energy (2.91 eV for MntopMo versus 0.65 eV for MnMo). Our results demonstrate that metal-doped layered materials, such as TMDs, constitute an emergent platform to construct ultrasensitive and tunable biosensors.

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Qi, Wenjing, Lei Chen, Chengpei Du, and Yi Wang. "A Ratiometric Fluorescence Probe of Dopamine-Functionalized Carbon Nanodots for Hypochlorite Detection." Chemosensors 10, no. 10 (September 22, 2022): 383. http://dx.doi.org/10.3390/chemosensors10100383.

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A dopamine-functionalized carbon nanodot (C-dots) ratiometric fluorescence probe for hypochlorite (ClO−) detection is reported. Fluorescent C-dots with maximal emission at 420 nm are synthesized via the hydrothermal synthesis of 3-hydroxyphenylboric acid at 160 °C for 8 h. After modified with dopamine for 5 min, the obtained dopamine-functionalized C-dots exhibit two maximal fluorescence emissions at 420 nm and 460 nm. Fluorescent intensity at 460 nm gets quenched with the addition of ClO− and fluorescent intensity at 420 nm is almost unaffected. Therefore dopamine-functionalized C-dots can be used as ratiometric fluorescence probe for highly sensitive detection of ClO−. The ratio of fluorescent intensity at 460 nm and 420 nm (I460nm/I420nm) has a linear relationship with the concentration of ClO− from 2 μM to 60 μM and limit of detection (LOD) of 0.6 μM. It shows high selectivity for the detection of ClO− toward other anions (SO42−, Cl−, NO3−, S2−, CO32−), metal ions (Mg2+, Ba2+, Ag+, Fe3+, Ca2+, Na+, Cr6+, Cr3+, Hg+), or other substances such as H2O2, glutamate, cysteine, and citric acid. When it is utilized in ClO− detection in tap water, the average recoveries are from 95.7% to 103.2% with the relative standard deviations (RSDs) lower than 5%.

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Zestos, Alexander George, Pauline Wonnenberg, Victoria Connaughton, and Kyle Laurie. "(Invited) Co-Detection of Dopamine and Metabolites Using Fast Scan Cyclic Voltammetry and Modified Carbon Fiber-Microelectrodes." ECS Meeting Abstracts MA2019-02, no. 55 (September 1, 2019): 2424. http://dx.doi.org/10.1149/ma2019-02/55/2424.

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Fast scan cyclic voltammetry (FSCV) and carbon-fiber microelectrodes (CFMEs) have been utilized used to detect several important neurochemicals in vivo. However, this method is limited due to the ability to discriminate dopamine from several of its metabolites. Carbon nanotube and polymer modified microelectrodes will be utilized to detect physiologically low levels of neurotransmitters that also resist surface fouling and have high temporal resolution to detect fast changes of neurotransmitters. Furthermore, novel electrode coatings and waveforms will also be utilized to detect several neurotransmitter metabolites such as dopamine, norepinephrine, normetanephrine, 3-methoxytyramine (3-MT), homovanillic acid (HVA), 3,4 dihydroxyphenylacetic acid (DOPAC), and other metabolites. Currently, dopamine is thought to be an important neurotransmitter concerning several disease states such Parkinson’s disease, drug abuse (amphetamine, cocaine, etc.), and even for gambling and sex-disorders. However, dopamine is metabolized on a subsecond timescale, and studies have pointed to the importance of neurotransmitter metabolites in these disease states apart from dopamine. Presently, there is no method to selectively co-detect these neurotransmitter metabolites of dopamine utilizing FSCV. Through several waveform modifications and polymer electrode coatings, we develop a novel method to tune the detection of dopamine and said metabolites, which will help differentiate dopamine and respective metabolites through the shapes and positions of their respective cyclic voltammograms. Preliminary measurements have also been made in zebrafish whole brain ex vivo showing the application of this technique in biological tissue. Discriminating the detection of dopamine from its metabolites will have many implications in better understanding complex disease, behavioral, and pharmacological states.

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Ahangari, G., G. H. Shariati, M. R. Asadi, M. R. Ostadali, and H. R. Ahmadkhaniha. "Novel Mutation Detection of Regulatory Molecule Dopamine Gene Receptors (D1–D5) Encoding Analysis on Human Peripheral Blood Lymphocytes in Schizophrenia Patients." European Journal of Inflammation 7, no. 3 (September 2009): 145–52. http://dx.doi.org/10.1177/1721727x0900700304.

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There is much evidence which highlights the involvement of the dopamine system in the pathophysiology of schizophrenia. Recently, there have been reports of detected mutations in dopamine gene receptors in genomic DNA of schizophrenia. In this study, we attempt to determine whether there is mutation in encoding dopamine receptor. The PBMC was separated from whole blood by Ficoll-hypaque; the total cellular RNA was extracted and the cDNA was synthesized. This process followed by real-time PCR using primer pairs specific for five dopamine receptor mRNAs and β-actin as internal control. The results show the presence of all types of dopamine receptor types in lymphocytes. The mutational analysis of the obtained PCR products for the respective dopamine receptor fragments were analyzed by sequenced capillary system. The results presented in this study confirm the high frequency of mutations in dopamine gene receptor DRD5 in schizophrenia patients. Mutational amino acid changes in dopamine gene receptors of DR2, DR3, DR4 but not DR1 are also shown. In conclusion, this is the first report of such complete mutational analyses in all dopamine gene receptors. Moreover, we found new mutations and 80% frequency of mutations in DRD5. These data further strengthen the argument for the role of dopamine gene receptor mutations in the pathogenesis of schizophrenia.

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Michałowska, Aleksandra, Kacper Jędrzejewski, and Andrzej Kudelski. "Influence of the Co-Adsorbed Ions on the Surface-Enhanced Raman Scattering Spectra of Dopamine Adsorbed on Nanostructured Silver." Materials 15, no. 17 (August 29, 2022): 5972. http://dx.doi.org/10.3390/ma15175972.

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The abnormal metabolism or imbalance of dopamine may lead to some neurological disorders. Therefore, the facile and fast detection of this neurotransmitter is essential in the early diagnosis of some diseases. One of the methods that can be used for the detection and determination of dopamine is the surface-enhanced Raman scattering (SERS). In this contribution, we report a very strong influence of some salts (we used salts containing Na+ cations and the following anions: SO42−, F−, Cl−, Br−, and I−) on the spectral patterns and intensity of the SERS spectra of dopamine adsorbed on a nanostructured macroscopic silver substrate. The analysis of the recorded SERS spectra based on the assignments of Raman bands from the density-functional theory (DFT) calculations and based on the SERS surface selection rules reveals that when molecules of dopamine are adsorbed from an aqueous solution to which no electrolytes have been added, they adopt a flat orientation versus the silver surface; whereas, the molecules of dopamine co-adsorbed with various ions interact with the silver surface, mainly via phenolic groups, and they adopt a perpendicular orientation versus the metal surface. An addition of electrolytes also significantly influences the intensity of the recorded SERS spectrum; for example, an addition of Na2SO4 to a final concentration of 1 M induces an increase in the intensity of the measured SERS spectrum by a factor of ca. 40. This means that the addition of electrolytes to the analyzed solution can reduce the limit of detection of dopamine by SERS spectroscopy. The abovementioned findings may facilitate the construction of dopamine SERS sensors.

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Journal articles on the topic 'Dopamine detection'

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