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Journal articles on the topic 'Domotic Effect'

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Author: Grafiati

Published: 14 March 2023

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1

AGUILERA, R. CARREÑO, J. J. MEDEL JUAREZ, and S. L. GOMEZ CORONEL. "PARAMETER ESTIMATION SPACE FOR UNKNOWN INTERNAL EVOLUTION ON IOT DOMOTIC SYSTEMS." Fractals 28, no. 03 (March 16, 2020): 2050066. http://dx.doi.org/10.1142/s0218348x20500668.

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This paper describes the parameter estimation modeling concerning a domotic designer bot system with internet of things (IoT) assistance using the probabilistic operator based on the stochastic parameter estimation through the moments and the recursive conditions. Light, CCTV, presence, and temperature are IoT data monitored, shared, and accessed by the internet for a smart office designer performance that evolves based on historical web data. The relationship established by Wiener between covariance and variance found the parameter time evolution by observing through the time. The development is viewed in the visible results between non-recursive and recursive mathematical structures. In both cases, the convergence rate is based on probabilistic estimation, the functional error presents a high convergence rate which is viewed as an effect of the function of a density function. The estimate considered a non-invasive perspective, and it helps in different applications such as health diagnosis in humans and animals with internal problems, or systems which are unknown for internal evolution such as for IoT model adoption. Therefore, our objective is to propose a black box, inner approximation through the parameter estimation without a no invasive stochastic method based in Wiener approximation.

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2

Debonnel, Guy, Michel Weiss, and Claude de Montigny. "Reduced neuroexcitatory effect of domoic acid following mossy fiber denervation of the rat dorsal hippocampus: further evidence that toxicity of domoic acid involves kainate receptor activation." Canadian Journal of Physiology and Pharmacology 67, no. 8 (August 1, 1989): 904–8. http://dx.doi.org/10.1139/y89-142.

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Domoic acid, an excitatory amino acid structurally related to kainic acid, has been shown to be responsible for the severe intoxication presented, in 1987, by more than one hundred and fifty people having eaten mussels grown in Prince Edward Island (Canada). Unitary extracellular recordings were obtained from pyramidal neurons of the CA3 region of the rat dorsal hippocampus. The excitatory effects of microiontophoretic applications of domoic acid and of the agonists of the two other subtypes of glutamatergic receptors, quisqualate and N-methyl-D-aspartate, were compared on intact and colchicine-lesioned sides. Similar to what has been previously found for kainate, the colchicine lesion of the mossy fiber projections induced a 95% decrease of the neuronal responsiveness to domoic acid, whereas the effect of quisqualate was unchanged and that of N-methyl-D-aspartate was only slightly decreased. These results provide further electrophysiological evidence that domoic acid is a potent agonist of kainate receptors and that it may produce its neuroexcitatory and neurotoxic effects, in the hippocampal CA3 region, through activation of kainate receptors located on the mossy fiber terminals.Key words: domoic acid, kainic acid, glutamic acid, N-methyl-D-aspartic acid, quisqualic acid, dorsal hippocampus, neurotoxins.

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3

Debonnel, Guy, Luc Beauchesne, and Claude de Montigny. "Domoic acid, the alleged "mussel toxin," might produce its neurotoxic effect through kainate receptor activation: an electrophysiological study in the rat dorsal hippocampus." Canadian Journal of Physiology and Pharmacology 67, no. 1 (January 1, 1989): 29–33. http://dx.doi.org/10.1139/y89-005.

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Domoic acid, an excitatory amino acid structurally related to kainate, was recently identified as being presumably responsible for the recent severe intoxication presented by more than 100 people having eaten mussels grown in Prince Edward Island (Canada). The amino acid kainate has been shown to be highly neurotoxic to the hippocampus, which is the most sensitive structure in the central nervous system. The present in vivo electrophysiological studies were undertaken to determine if domoic acid exerts its neurotoxic effect via kainate receptor activation. Unitary extracellular recordings were obtained from pyramidal neurons of the CA1 and the CA3 regions of the rat dorsal hippocampus. The excitatory effect of domoic acid applied by microiontophoresis was compared with that of agonists of the three subtypes of glutamatergic receptors: kainate, quisqualate, and N-methyl-D-aspartate. In CA1, the activation induced by domoic acid was about threefold greater than that induced by kainate; identical concentrations and similar currents were used. In CA3, domoic acid was also three times more potent than kainate. However, the most striking finding was that domoic acid, similar to kainate, was more than 20-fold more potent in the CA3 than in the CA1 region, whereas no such regional difference could be detected with quisqualate and N-methyl-D-aspartate. As the differential regional response of CA1 and CA3 pyramidal neurons to kainate is attributable to the extremely high density of kainate receptors in the CA3 region, these results provide the first electrophysiological evidence that domoic acid may produce its neurotoxic effects through kainate receptor activation.Key words: domoate, kainate, excitotoxin, hippocampus, N-methyl-D-aspartate.

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4

Johannessen, Jan N. "Stability of Domoic Acid in Saline Dosing Solutions." Journal of AOAC INTERNATIONAL 83, no. 2 (March 1, 2000): 411–12. http://dx.doi.org/10.1093/jaoac/83.2.411.

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Abstract Studies designed to assess the effects of repeated low doses of domoic acid require an assessment of its stability in solution under the conditions used for in vivo studies. The stability of 1 mg/mL solutions of domoic acid in saline, with or without ascorbic acid, was determined for 15 weeks. Solutions were refrigerated, but warmed to room temperature for several hours each working day to simulate conditions of actual use. The solutions of domoic acid showed no evidence of decomposition as evidenced by stability of UV absorbance spectrum, concentration of domoic acid as determined by a liquid chromatographic method, and the chromatographic elution pattern. The addition of ascorbate to the domoic acid/saline solution did not alter the stability, but was deemed unnecessary because of the firm stability of the domoic acid/saline solution.

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5

Falk, Michael, Ping F. Seto, and John A. Walter. "Solubility of domoic acid in water and in non-aqueous solvents." Canadian Journal of Chemistry 69, no. 11 (November 1, 1991): 1740–44. http://dx.doi.org/10.1139/v91-255.

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The solubility of domoic acid (DA) in H2O and D2O, in aqueous NaCl solution and in several non-aqueous solvents was measured by NMR and UV spectroscopies. The solubility in water is comparable with that of aminoacids such as glutamic acid and aspartic acid. It is markedly pH-dependent, passing through a minimum at the isoelectric point, the increase towards both higher and lower pH values indicating that the anionic and cationic forms are more soluble than the neutral form. The effect of NaCl on the solubility of DA in water is negligible. The solubility of DA in alcohols is lower than in water but it is much higher than the solubility of glutamic acid or aspartic acid. The octanol–water partition coefficient for DA at pH 5.32, Kow = 0.0037, was obtained by a direct UV measurement. The low value of Kow indicates that aquatic organisms cannot take up DA directly from the water and bioaccumulation may proceed only through dietary intake. Key words: solubility of domoic acid, NMR of domoic acid, UV spectra of domoic acid, octanol–water partition coefficient of domoic acid.

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6

Novaczek, I., M. S. Madhyastha, R. F. Ablett, A. Donald, G. Johnson, M. S. Nijjar, and D. E. Sims. "Depuration of Domoic Acid from Live Blue Mussels (Mytilus edulis)." Canadian Journal of Fisheries and Aquatic Sciences 49, no. 2 (February 1, 1992): 312–18. http://dx.doi.org/10.1139/f92-035.

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Industrial depuration may provide a means of removing domoic acid toxin from blue mussels (Mytilus edulis). Mussels containing up to 50 μg domoic acid∙g−1 were transported from a Prince Edward Island estuary into controlled laboratory conditions to test the effects of temperature, salinity, mussel size, and feeding upon depuration. Fifty percent of toxin was eliminated within 24 h. After 72 h, mussels were either clean or contained, on average, only residual levels of toxin (< 5 μg∙g−1), regardless of conditions. Exponential depuration curves were fitted to the domoic acid concentration data. To evaluate differences in rate of depuration under various conditions, statistical comparisons were made between slopes of the clearance curves. Rates of depuration were faster in small (45–55 mm) than in large mussels (60–70 mm) and more rapid at 11 than at 6 °C. There was no significant difference in depuration rate at 18‰ salinity as opposed to 28‰ or in starved versus fed mussels. Because of their relatively large digestive glands, meats of small mussels contained more toxin per unit weight than meats of large mussels. The bulk of domoic acid appeared to reside in the gut lumen. However, the presence of small amounts of domoic acid in intracellular compartments cannot be ruled out.

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7

Corno, Fulvio, and Faisal Razzak. "SAT based enforcement of domotic effects in smart environments." Journal of Ambient Intelligence and Humanized Computing 5, no. 4 (April 23, 2013): 565–79. http://dx.doi.org/10.1007/s12652-013-0183-x.

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8

Garroppo, Rosario G., Loris Gazzarrini, Stefano Giordano, and Luca Tavanti. "Experimental Evaluation of a SIP-Based Home Gateway with Multiple Wireless Interfaces for Domotics Systems." Journal of Computer Networks and Communications 2012 (2012): 1–15. http://dx.doi.org/10.1155/2012/190639.

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In modern houses, the presence of sensors and actuators is increasing, whilecommunication servicesandentertainment systemshad long since settled into everyday life. The utilization of wireless communication technologies, such as ZigBee, Wi-Fi, and Bluetooth, is attractive because of their short installation times and low costs. The research is moving towards the integration of the various home appliances and devices into a single domotics system, able to exploit the cooperation among the diverse subsystems and offer the end-user a single multiservice platform. In this scenario, the paper presents the experimental evaluation of a domotics framework centered on a SIP-based home gateway (SHG). While SIP is used to build a common control plane, the SHG is in charge of translating the user commands from and to the specific domotics languages. The analysis has been devoted to assess both the performance of the SHG software framework and the negative effects produced by the simultaneous interference among the three widespread wireless technologies.

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9

Morgavi, Giovanna. "A Virtual Village Network Architecture for improving the elderly people quality of life." Inteligencia Artificial 18, no. 55 (June 18, 2015): 26. http://dx.doi.org/10.4114/intartif.vol18iss55pp26-34.

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Elder people often feel pushed to the margins by the generational shift and suffer from loss of identity and hence they lose motivation, recognition and self-esteem: they are often considered to be no longer capable of performing any service. This paper proposes an ICT network architecture oriented to improve the quality of life of elderly people and their caregivers focused on the user need satisfaction and reducing negative feelings like insecurity, vulnerability, loneliness and depression. This Virtual Village Network architecture is organized on 3 levels: 1. the Virtual Service Centre (VSC) that, through a proper home interface, carries out the support, the monitoring, the prevention and the social facilitation; 2. the Intelligent Domotic Health Networks (DHN) a domotic modular network with high local evaluation ability through which the VSC can monitor the home and/or the user’s state of wellness and of health ; 3. the Dynamical Village Network (DVN) that is an ICT network of users. The idea is to build an ICT network of “virtual social neighbours” facilitating user relationships, able to have positive influences on the interactive abilities and self-image of the elderly, and to prevent or overcome solitude, isolation and their negative effects on the elderly person’s overall quality of life and health. The whole architecture is pervaded by strict attention paid to security and privacy.

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10

Ventoso, Pablo, Antonio J. Pazos, M. Luz Pérez-Parallé, Juan Blanco, Juan C. Triviño, and José L. Sánchez. "Aequipecten opercularis) Digestive Gland after Exposure to Domoic Acid-Producing Pseudo-nitzschia." Toxins 11, no. 2 (February 6, 2019): 97. http://dx.doi.org/10.3390/toxins11020097.

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Some species of the genus Pseudo-nitzschia produce the toxin domoic acid, which causes amnesic shellfish poisoning (ASP). Given that bivalve mollusks are filter feeders, they can accumulate these toxins in their tissues. To elucidate the transcriptional response of the queen scallop Aequipecten opercularis after exposure to domoic acid-producing Pseudo-nitzschia, the digestive gland transcriptome was de novo assembled using an Illumina HiSeq 2000 platform. Then, a differential gene expression analysis was performed. After the assembly, 142,137 unigenes were obtained, and a total of 10,144 genes were differentially expressed in the groups exposed to the toxin. Functional enrichment analysis found that 374 Pfam (protein families database) domains were significantly enriched. The C1q domain, the C-type lectin, the major facilitator superfamily, the immunoglobulin domain, and the cytochrome P450 were among the most enriched Pfam domains. Protein network analysis showed a small number of highly connected nodes involved in specific functions: proteasome components, mitochondrial ribosomal proteins, protein translocases of mitochondrial membranes, cytochromes P450, and glutathione S-transferases. The results suggest that exposure to domoic acid-producing organisms causes oxidative stress and mitochondrial dysfunction. The transcriptional response counteracts these effects with the up-regulation of genes coding for some mitochondrial proteins, proteasome components, and antioxidant enzymes (glutathione S-transferases, thioredoxins, glutaredoxins, and copper/zinc superoxide dismutases).

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11

Cabrera, Joaquin, Susana Puntarulo, and Paula Mariela González. "Domoic Acid Oxidative Effects on the Microalgae Phaeodactylum tricornutum." Life 13, no. 3 (March 2, 2023): 676. http://dx.doi.org/10.3390/life13030676.

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Domoic acid (DA) is a natural occurring marine biotoxin. Oxidative stress generation due to DA exposure was reported in animals, but little is known on the phytoplankton community. The aim of this work was to verify whether exposure to DA in the marine diatom Phaeodactylum tricornutum favors reactive oxygen species (ROS) generation in the intracellular environment modifying its antioxidant capacity. Active species production, non-enzymatic antioxidant content, and antioxidant enzyme activities over the three growth phases of P. tricornutum exposed to 64 µM DA were evaluated. Results obtained in exponential growing cells showed a time-depending seven-fold increase in the 2′,7′ dichlorofluorescein diacetate dye oxidation rate. Superoxide dismutase and catalase activities showed a two-fold increase, and glutathione related enzymes activities were also significantly increased in treated diatoms as compared to controls. However, glutathione and ascorbate contents significantly decreased after incubation of the cells with DA. Similar effects were observed in latent and stationary phases of cell development. These results showed that DA could cause a severe oxidant-dependent impact on a non-toxic algae.

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12

Olesen, Anna J., Anneliese Leithoff, Andreas Altenburger, Bernd Krock, Bánk Beszteri, Sarah Lena Eggers, and Nina Lundholm. "First Evidence of the Toxin Domoic Acid in Antarctic Diatom Species." Toxins 13, no. 2 (January 26, 2021): 93. http://dx.doi.org/10.3390/toxins13020093.

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The Southern Ocean is one of the most productive ecosystems in the world. It is an area heavily dependent on marine primary production and serving as a feeding ground for numerous seabirds and marine mammals. Therefore, the phytoplankton composition and presence of toxic species are of crucial importance. Fifteen monoclonal strains of Pseudo-nitzschia subcurvata, a diatom species endemic to the Southern Ocean, were established, which were characterized by morphological and molecular data and then analysed for toxin content. The neurotoxins domoic acid and iso-domoic acid C were present in three of the strains, which is a finding that represents the first evidence of these toxins in strains from Antarctic waters. Toxic phytoplankton in Antarctic waters are still largely unexplored, and their effects on the ecosystem are not well understood. Considering P. subcurvata’s prevalence throughout the Southern Ocean, these results highlight the need for further investigations of the harmful properties on the Antarctic phytoplankton community as well as the presence of the toxins in the Antarctic food web, especially in the light of a changing climate.

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13

Nogueira, Isabel, Alexandre Lobo-da-Cunha, António Afonso, Socorro Rivera, Joana Azevedo, Rogério Monteiro, Rosa Cervantes, Ana Gago-Martinez, and Vítor Vasconcelos. "Toxic Effects of Domoic Acid in the Seabream Sparus aurata." Marine Drugs 8, no. 10 (October 15, 2010): 2721–32. http://dx.doi.org/10.3390/md8102721.

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14

Baron, Andrew W., Steven P. Rushton, Natalie Rens, Christopher M. Morris, Peter G. Blain, and Sarah J. Judge. "Sex differences in effects of low level domoic acid exposure." NeuroToxicology 34 (January 2013): 1–8. http://dx.doi.org/10.1016/j.neuro.2012.10.010.

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15

Arias, B., M. Arufe, M. Alfonso, and R. Duran. "Effect of domoic acid on metabolism of 5-hydroxytryptamine in rat brain." Neurochemical Research 20, no. 4 (April 1995): 401–4. http://dx.doi.org/10.1007/bf00973094.

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16

Geng, Zihan, and Haoyuan Li. "The Impact of Climate Change on The Bioavailability of Environmental Toxins and Their Toxicological Effects." Highlights in Science, Engineering and Technology 6 (July 27, 2022): 33–44. http://dx.doi.org/10.54097/hset.v6i.931.

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Climate change has become one of the biggest challenges for the 21st century. Global warming, sea level rise, changes in weather conditions, and atmospheric contamination caused by climate change not only have impacts on nature but also present threats to human health. Climate change can influence the generations and distribution of some representative toxic compounds with specific examples, including heavy metals (arsenic and manganese), persistent organic pollutants (POPs), air pollutants, and biotoxins (domoic acid and β-N-methylamino-L-alanine). This review discusses how the effects of climate change drive the production and spread of toxic substances that enter the human body through different means as well as presents the biochemical mechanisms and experimental evidence of their toxicological effect on human health, which provides an insight on climate change allowing toxic substances to enter human body and calls on readers to understand and pay attention to climate change from a more comprehensive aspect

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17

Levin, Edward D., Wyki Gina Pang, Jerry Harrison, Paul Williams, Ann Petro, and John S. Ramsdell. "Persistent neurobehavioral effects of early postnatal domoic acid exposure in rats." Neurotoxicology and Teratology 28, no. 6 (November 2006): 673–80. http://dx.doi.org/10.1016/j.ntt.2006.08.005.

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18

Radad, Khaled, Rudolf Moldzio, Mubarak Al-Shraim, Ahmed Al-Emam, and Wolf-Dieter Rausch. "Long-term neurotoxic effects of domoic acid on primary dopaminergic neurons." Toxicology in Vitro 52 (October 2018): 279–85. http://dx.doi.org/10.1016/j.tiv.2018.07.004.

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19

Hogberg, Helena T., and Anna K. Bal-Price. "Domoic Acid-Induced Neurotoxicity Is Mainly Mediated by the AMPA/KA Receptor: Comparison between Immature and Mature Primary Cultures of Neurons and Glial Cells from Rat Cerebellum." Journal of Toxicology 2011 (2011): 1–14. http://dx.doi.org/10.1155/2011/543512.

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Domoic acid (DomA) is a naturally occurring shellfish toxin that can induce brain damage in mammalians. Neonates have shown increased sensitivity to DomA-induced toxicity, and prenatal exposure has been associated with e.g. decreased brain GABA levels, and increased glutamate levels. Here, we evaluated DomA-induced toxicity in immature and mature primary cultures of neurons and glial cells from rat cerebellum by measuring the mRNA levels of selected genes. Moreover, we assessed if the induced toxicity was mediated by the activation of the AMPA/KA and/or the NMDA receptor. The expression of all studied neuronal markers was affected after DomA exposure in both immature and mature cultures. However, the mature cultures seemed to be more sensitive to the treatment, as the effects were observed at lower concentrations and at earlier time points than for the immature cultures. The DomA effects were completely prevented by the antagonist of the AMPA/KA receptor (NBQX), while the antagonist of the NMDA receptor (APV) partly blocked the DomA-induced effects. Interestingly, the DomA-induced effect was also partly prevented by the neurotransmitter GABA. DomA exposure also affected the mRNA levels of the astrocytic markers in mature cultures. These DomA-induced effects were reduced by the addition of NBQX, APV, and GABA.

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20

Bargu, S., K. Lefebvre, and MW Silver. "Effect of dissolved domoic acid on the grazing rate of krill Euphasia pacifica." Marine Ecology Progress Series 312 (April 24, 2006): 169–75. http://dx.doi.org/10.3354/meps312169.

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21

Van Meerssche, Elise, and James L. Pinckney. "The influence of salinity in the domoic acid effect on estuarine phytoplankton communities." Harmful Algae 69 (November 2017): 65–74. http://dx.doi.org/10.1016/j.hal.2017.10.003.

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22

McCarron, Pearse, Elliott Wright, and Michael A. Quilliam. "Liquid Chromatography/Mass Spectrometry of Domoic Acid and Lipophilic Shellfish Toxins with Selected Reaction Monitoring and Optional Confirmation by Library Searching of Product Ion Spectra." Journal of AOAC INTERNATIONAL 97, no. 2 (March 1, 2014): 316–24. http://dx.doi.org/10.5740/jaoacint.sgemccarron.

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Abstract LC/MS methodology for the analysis of domoic acidand lipophilic toxins in shellfish was developed using a hybrid triple quadrupole linear ion trap mass spectrometer. For routine quantitation a scheduled selected reaction monitoring (SRM) method for the analysis of domoic acid, okadaic acid, dinophysistoxins,azaspiracids, pectenotoxins, yessotoxins, gymnodimines, spirolides, and pinnatoxins was developed and validated. The method performed well in terms of LOD, linearity, precision, and trueness. Taking advantageof the high instrument sensitivity, matrix effects were mitigated by reducing the amount of sample introduced to the mass spectrometer. Optionally, samples can be analyzed using information dependent acquisition (IDA) methods, either in positive or negative mode, which can provide an extra level of confirmationby matching the full product ion spectra acquired for a sample with those from a specially constructedspectral library. Methods were applied to the analysisof a new certified reference material and Canadian mussels (Mytilus edulis) implicated in a 2011 diarrhetic shellfish poisoning (DSP) incident. The scheduled SRM method enabled the screening and quantitation of multiple phycotoxins. As DSPhad not previously been observed in this area of Canada,positive identification of putative toxins was accomplished using the IDA and spectral search method. Analysis of the 2011 toxic mussel samples revealed thepresence of high levels of dinophysistoxin-1, which explained the DSP symptoms, as well as pectenotoxins, yessotoxins, and variety of cyclic imines.

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Arufe, M. C., B. Arias, R. Durán, and M. Alfonso. "Effects of domoic acid on serum levels of TSH and thyroid hormones." Endocrine Research 21, no. 3 (January 1995): 671–80. http://dx.doi.org/10.1080/07435809509030482.

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24

Levin, Edward. "Persisting cognitive effects of pre vs. postnatal domoic acid exposure in rats." Neurotoxicology and Teratology 31, no. 4 (July 2009): 243. http://dx.doi.org/10.1016/j.ntt.2009.04.030.

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25

Tian, Dongmei, and Ganlan Zhang. "Toxic Effects of Domoic Acid on Caenorhabditis elegans and the Underlying Mechanism." International Journal of Biology 11, no. 3 (May 4, 2019): 1. http://dx.doi.org/10.5539/ijb.v11n3p1.

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Domoic acid (DA) is a well-known marine bio-toxin and has been investigated extensively through many in vitro and in vivo studies. However, the mechanism for DA-induced toxicity is still not fully understood. In the present study, we performed toxicity assessment of DA in Caenorhabditis elegans system and investigated the underlying mechanism for DA-induced toxicity. Our data show that DA exposure has toxic effects on locomotion behavior, lifespan and intestine of nematodes. Moreover, we observed the increased reactive oxygen species (ROS) formation in DA exposed nematodes, implying the involvement of oxidative stress in DA-induced toxicity. In addition, our data demonstrates that p38 signaling pathway is required for the DA-induced ROS formation and toxicity. Therefore, our study proves the effectiveness of C. elegans system in toxicity assessment of DA, and DA may induce toxicity through p38 pathway dependent oxidative stress.

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Ayed, Yosra, Bochra Kouidhi, Saba Kassim, and Hassen Bacha. "Proliferative effect of the phycotoxin domoic acid on cancer cell lines: a preliminary evaluation." Journal of Taibah University for Science 12, no. 1 (January 2, 2018): 11–16. http://dx.doi.org/10.1080/16583655.2018.1451107.

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27

Guillotin, Sophie, and Nicolas Delcourt. "Marine Neurotoxins’ Effects on Environmental and Human Health: An OMICS Overview." Marine Drugs 20, no. 1 (December 23, 2021): 18. http://dx.doi.org/10.3390/md20010018.

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Harmful algal blooms (HAB), and the consequent release of toxic metabolites, can be responsible for seafood poisoning outbreaks. Marine wildlife can accumulate these toxins throughout the food chain, which presents a threat to consumers’ health. Some of these toxins, such as saxitoxin (STX), domoic acid (DA), ciguatoxin (CTX), brevetoxin (BTX), tetrodotoxin (TTX), and β-N-methylamino-L-alanine (BMAA), cause severe neurological symptoms in humans. Considerable information is missing, however, notably the consequences of toxin exposures on changes in gene expression, protein profile, and metabolic pathways. This information could lead to understanding the consequence of marine neurotoxin exposure in aquatic organisms and humans. Nevertheless, recent contributions to the knowledge of neurotoxins arise from OMICS-based research, such as genomics, transcriptomics, proteomics, and metabolomics. This review presents a comprehensive overview of the most recent research and of the available solutions to explore OMICS datasets in order to identify new features in terms of ecotoxicology, food safety, and human health. In addition, future perspectives in OMICS studies are discussed.

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Radad, Khaled, Mubarak Al-Shraim, Ahmed Al-Emam, Rudolf Moldzio, and Wolf-Dieter Rausch. "Neurotoxic effects of domoic acid on dopaminergic neurons in primary mesencephalic cell culture." Folia Neuropathologica 56, no. 1 (2018): 39–48. http://dx.doi.org/10.5114/fn.2018.74658.

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29

Schaffer, P., C. Reeves, D. R. Casper, and C. R. Davis. "Absence of neurotoxic effects in leopard sharks, Triakis semifasciata, following domoic acid exposure." Toxicon 47, no. 7 (June 2006): 747–52. http://dx.doi.org/10.1016/j.toxicon.2006.01.030.

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30

Ross, I. A., W. Johnson, P. P. Sapienza, and C. S. Kim. "Effects of the seafood toxin domoic acid on glutamate uptake by rat astrocytes." Food and Chemical Toxicology 38, no. 11 (November 2000): 1005–11. http://dx.doi.org/10.1016/s0278-6915(00)00083-1.

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31

Sobotka, T. "Domoic acid: Neurobehavioral and neurohistological effects of low-dose exposure in adult rats." Neurotoxicology and Teratology 18, no. 6 (December 1996): 659–70. http://dx.doi.org/10.1016/s0892-0362(96)00120-1.

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32

Holland, Patrick T., Paul McNabb, Andrew I. Selwood, and Tracey Neil. "Amnesic Shellfish Poisoning Toxins in Shellfish: Estimation of Uncertainty of Measurement for a Liquid Chromatography/Tandem Mass Spectrometry Method." Journal of AOAC INTERNATIONAL 86, no. 5 (September 1, 2003): 1095–100. http://dx.doi.org/10.1093/jaoac/86.5.1095.

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Abstract A liquid chromatography/mass spectrometry (LC/MS) method for amnesic shellfish poisoning toxins in shellfish was developed and validated. Tissue homogenate (4 g) was extracted with 16 mL methanol–water (1 + 1, v/v). Dilution into acetonitrile–water (1 + 9, v/v) was followed by C18 solid-phase extraction cleanup. Domoic acid (DA) and epi-domoic acid were determined by LC/MS/MS with electrospray ionization and multiple reaction monitoring. External calibration was performed with dilutions of a certified reference standard. Advantages of this method include speed, lower detection limits, and a very high degree of specificity. The LC/MS response was highly linear, and there were no significant interferences to the determination of DA. Formal method validation was performed on 4 shellfish species. Fortification studies gave recoveries (mean ± SD; n = 24) of 93 ± 14% at 1 mg/kg, and 93.3 ± 7.6% at 20 mg/kg over all the species. Analysis of a mussel certified reference material showed the bias as <5%. The limits of detection and quantitation were 0.15 and 0.5 mg/kg, respectively. Routine application of the method over 4 months gave a recovery for the QC sample (1 mg/kg fortified blank mussel homogenate) run with each batch of 88.9 ± 5.5% (mean ± SD; n = 37). The total uncertainty of measurement results were estimated as 0.12 (12%) at 0.25–5 mg/kg and 0.079 (7.9%) at 5–50 mg/kg. The major contribution to the uncertainty was the repeatability of the LC/MS determination, probably arising from subtle matrix effects.

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Adamski, Michal, and Ariel Kaminski. "Effect of Microcystin-LR, Nodularin, Anatoxin-a, β-N-Methylamino-L-Alanine and Domoic Acid on Antioxidant Properties of Glutathione." Life 12, no. 2 (January 31, 2022): 227. http://dx.doi.org/10.3390/life12020227.

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Cyanobacteria produce a range of toxic secondary metabolites that affect many processes in human, animal and also plant cells. In recent years, some efforts have concentrated on deepening the understanding of their effect on living cells in the context of the disruption of antioxidant systems. Many results suggest that cyanotoxins interfere with glutathione (GSH) metabolism, which often leads to oxidative stress and, in many cases, cell death. Knowledge about the influence of cyanotoxins on enzymes involved in GSH synthesis or during its antioxidant action is relatively broad. However, to date, there is no information about the antioxidant properties of GSH after its direct interaction with cyanotoxins. In this paper, we investigated the effect of four cyanotoxins belonging to the groups of hepatotoxins (microcystin-LR and nodularin) or neurotoxins (anatoxin-a and β-N-methylamino-L-alanine) on the in vitro antioxidant properties of GSH. Moreover, the same study was performed for domoic acid (DA) produced by some diatoms. The obtained results showed that none of the studied compounds had an effect on GSH antioxidant potential. The results presented in this paper are, to the best of our knowledge, the first description of the kinetics of scavenging radicals by GSH reactions under the influence of these cyanotoxins and DA. This work provides new and valuable data that broadens the knowledge of the impact of cyanotoxins and DA on GSH metabolism and complements currently available information. Future studies should focus on the effects of the studied compounds on antioxidant systems in vivo.

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Liu, Hui, Maeve S. Kelly, Dirk A. Campbell, Jianguang Fang, and Jianxin Zhu. "Accumulation of domoic acid and its effect on juvenile king scallop Pecten maximus (Linnaeus, 1758)." Aquaculture 284, no. 1-4 (November 2008): 224–30. http://dx.doi.org/10.1016/j.aquaculture.2008.07.003.

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35

Picot, C., G. Limon, G. Durand, N. Wesolek, D. Parent-Massin, and A. C. Roudot. "Domoic Acid, Okadaic Acid and Spirolides: Inter-Species Variability in Contamination and Cooking Effects." Food and Public Health 2, no. 2 (August 31, 2012): 50–57. http://dx.doi.org/10.5923/j.fph.20120202.09.

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36

Lundholm, N., PJ Hansen, and Y. Kotaki. "Lack of allelopathic effects of the domoic acid-producing marine diatom Pseudo-nitzschia multiseries." Marine Ecology Progress Series 288 (2005): 21–33. http://dx.doi.org/10.3354/meps288021.

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37

Grant, Kimberly, Tom Burbacher, Sparkle Roberts, and Lynn Grattan. "Effects of domoic acid on early visual memory in infants from the Coastal Cohort." Neurotoxicology and Teratology 32, no. 4 (July 2010): 507. http://dx.doi.org/10.1016/j.ntt.2010.04.039.

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Tasker, R. A. R., M. A. Perry, T. A. Doucette, and C. L. Ryan. "NMDA receptor involvement in the effects of low dose domoic acid in neonatal rats." Amino Acids 28, no. 2 (February 18, 2005): 193–96. http://dx.doi.org/10.1007/s00726-005-0167-z.

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39

Nakajima, Shinshu, and James L. Potvin. "Neural and behavioural effects of domoic acid, an amnesic shellfish toxin, in the rat." Canadian Journal of Psychology/Revue canadienne de psychologie 46, no. 4 (1992): 569–81. http://dx.doi.org/10.1037/h0084334.

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40

Barbaro, Elena, Roberta Zangrando, Carlo Barbante, and Andrea Gambaro. "Fast and Sensitive Method for Determination of Domoic Acid in Mussel Tissue." Scientific World Journal 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/8404092.

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Domoic acid (DA), a neurotoxic amino acid produced by diatoms, is the main cause of amnesic shellfish poisoning (ASP). In this work, we propose a very simple and fast analytical method to determine DA in mussel tissue. The method consists of two consecutive extractions and requires no purification steps, due to a reduction of the extraction of the interfering species and the application of very sensitive and selective HILIC-MS/MS method. The procedural method was validated through the estimation of trueness, extract yield, precision, detection, and quantification limits of analytical method. The sample preparation was also evaluated through qualitative and quantitative evaluations of the matrix effect. These evaluations were conducted both on the DA-free matrix spiked with known DA concentration and on the reference certified material (RCM). We developed a very selective LC-MS/MS method with a very low value of method detection limit (9 ng g−1) without cleanup steps.

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41

Chi, Cheng, Caiyan Zhang, Jiadai Liu, and Xiaochuan Zheng. "Effects of Marine Toxin Domoic Acid on Innate Immune Responses in Bay Scallop Argopecten irradians." Journal of Marine Science and Engineering 7, no. 11 (November 9, 2019): 407. http://dx.doi.org/10.3390/jmse7110407.

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Domoic acid (DA) is an amnesic shellfish poisoning toxin produced by some species of the genera Pseudo-nitzschia and Nitzschia. This toxin has harmful effects on various species, especially scallops. This study aimed to investigate the effects of DA exposure on the immune and physical responses of bay scallop, Argopecten irradians. Various immunological and physical parameters were assessed (acid phosphatase (ACP), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), lipid peroxide (LPO), nitric oxide (NO), and the total protein content) in the haemolymph of scallops at 3, 6, 12, 24, and 48 h post-exposure to DA at different concentrations (10, 50, and 100 ng/mL). Moreover, the expression of immune-related genes (CLT-6, FREP, HSP90, MT, PGRP, and PrxV) was assessed. The activities of ACP, ALP, and LDH and the total protein content and LPO increased upon exposure to DA at different concentrations, while NO levels were decreased. Furthermore, immune-related genes were assessed upon DA exposure. Our results showed that exposure to DA negatively impacts immune function and disrupts physiological activities in bay scallops.

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Levin, Milton, Heather Leibrecht, James Ryan, Frances Van Dolah, and Sylvain De Guise. "Immunomodulatory Effects of Domoic Acid Differ Between In vivo and In vitro Exposure in Mice." Marine Drugs 6, no. 4 (December 22, 2008): 636–59. http://dx.doi.org/10.3390/md6040636.

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Park, Ju Young, Motohiro Shiotani, Toby Cole, Sungwoo Hong, William Griffith, Thomas Burbacher, Lucio Costa, and Elaine Faustman. "Prenatal exposure effects of repeated oral dose of domoic acid (DA) on neurobehavior in mice." Neurotoxicology and Teratology 37 (May 2013): 85. http://dx.doi.org/10.1016/j.ntt.2013.03.042.

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44

Ramya, E. M., G. Phani Kumar, T. Anand, and K. R. Anilakumar. "Modulatory effects of Terminalia arjuna against domoic acid induced toxicity in Caco-2 cell line." Cytotechnology 69, no. 4 (March 24, 2017): 725–39. http://dx.doi.org/10.1007/s10616-017-0080-9.

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Gill and Kumara. "Detecting Neurodevelopmental Toxicity of Domoic Acid and Ochratoxin A Using Rat Fetal Neural Stem Cells." Marine Drugs 17, no. 10 (October 4, 2019): 566. http://dx.doi.org/10.3390/md17100566.

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Currently, animal experiments in rodents are the gold standard for developmental neurotoxicity (DNT) investigations; however, testing guidelines for these experiments are insufficient in terms of animal use, time, and costs. Thus, alternative reliable approaches are needed for predicting DNT. We chose rat neural stem cells (rNSC) as a model system, and used a well-known neurotoxin, domoic acid (DA), as a model test chemical to validate the assay. This assay was used to investigate the potential neurotoxic effects of Ochratoxin A (OTA), of which the main target organ is the kidney. However, limited information is available regarding its neurotoxic effects. The effects of DA and OTA on the cytotoxicity and on the degree of differentiation of rat rNSC into astrocytes, neurons, and oligodendrocytes were monitored using cell-specific immunofluorescence staining for undifferentiated rNSC (nestin), neurospheres (nestin and A2B5), neurons (MAP2 clone M13, MAP2 clone AP18, and Doublecortin), astrocytes (GFAP), and oligodendrocytes (A2B5 and mGalc). In the absence of any chemical exposure, approximately 46% of rNSC differentiated into astrocytes and neurons, while 40.0% of the rNSC differentiated into oligodendrocytes. Both non-cytotoxic and cytotoxic concentrations of DA and OTA reduced the differentiation of rNSC into astrocytes, neurons, and oligodendrocytes. Furthermore, a non-cytotoxic nanomolar (0.05 µM) concentration of DA and 0.2 µM of OTA reduced the percentage differentiation of rNSC into astrocytes and neurons. Morphometric analysis showed that the highest concentrations (10 μM) of DA reduced axonal length. These indicate that low, non-cytotoxic concentrations of DA and OTA can interfere with the differentiation of rNSC.

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Dahl, Kelsey, Jim Perry, and Mark D. Williams. "Preliminary Study: Effects of domoic acid on the gonadotropin releasing hormone (GT1–7) neuronal cell line." BIOS 78, no. 4 (December 2007): 132–37. http://dx.doi.org/10.1893/0005-3155(2007)78[132:pseoda]2.0.co;2.

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FUKAMI, Jun-ichi. "Effects of Domoic and Kainic Acids on the Neuromuscular Junction of Mealworm, Tenebrio molitor : Coleoptera : Tenebrionidae." Applied Entomology and Zoology 21, no. 1 (1986): 179–81. http://dx.doi.org/10.1303/aez.21.179.

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48

Bejarano, Adriana C., Frances M. VanDola, Frances M. Gulland, Teresa K. Rowles, and Lori H. Schwacke. "Production and Toxicity of the Marine Biotoxin Domoic Acid and Its Effects on Wildlife: A Review." Human and Ecological Risk Assessment: An International Journal 14, no. 3 (June 2, 2008): 544–67. http://dx.doi.org/10.1080/10807030802074220.

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PENG, YONG G., and JOHN S. RAMSDELL. "Brain Fos Induction Is a Sensitive Biomarker for the Lowest Observed Neuroexcitatory Effects of Domoic Acid." Toxicological Sciences 31, no. 2 (1996): 162–68. http://dx.doi.org/10.1093/toxsci/31.2.162.

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Scallet, A. C., Z. Binienda, F. A. Caputo, S. Hall, M. G. Paule, R. L. Rountree, L. Schmued, T. Sobotka, and W. Slikker. "Domoic acid-treated cynomolgus monkeys (M. fascicularis): effects of dose on hippocampal neuronal and terminal degeneration." Brain Research 627, no. 2 (November 1993): 307–13. http://dx.doi.org/10.1016/0006-8993(93)90335-k.

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