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Dissertations / Theses on the topic 'Domoic acid'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Parekh, Punam K. "The Photooxidation of Domoic Acid." FIU Digital Commons, 2012. http://digitalcommons.fiu.edu/etd/770.

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Domoic acid (DA) is a naturally occurring cyanotoxin, which upon ingestion, is responsible for amnesic shellfish poisoning (ASP) in both humans and animals. Produced by the marine diatom, Pseudonitzschia, DA is accumulated by a number of marine organisms including shellfish, clams and mussels which upon consumption can lead to headaches, nausea and seizures. Possessing a variety of functional groups the structure of DA contains three carboxyl groups, a pyrrole ring and a potent conjugated diene region allowing for binding to glutamate receptors in the dorsal hippocampus of the brain causing th

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2

Fleary-Roberts, Nadia. "Towards the total synthesis of domoic acid and the isodomoic acids." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/towards-the-total-synthesis-of-domoic-acid-and-the-isodomoic-acids(a32fd085-8e09-47b5-b533-ef259b1ae8a2).html.

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3

Sedehizadeh, Simon. "Towards the total synthesis of domoic acid and the isodomoic acids." Thesis, University of Manchester, 2010. https://www.research.manchester.ac.uk/portal/en/theses/towards-the-total-synthesis-of-domoic-acid-and-the-isodomoic-acids(6a1a5ea8-f5a5-4185-8222-5d3486165ac9).html.

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4

Silvagni, Paul Anthony. "Comparative pathology and diagnosis of domoic acid toxicity /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2003. http://uclibs.org/PID/11984.

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5

Lail, Erin M. "Biogeochemical cycling of domoic acid and its isomers in the ocean /." Electronic version (PDF), 2006. http://dl.uncw.edu/etd/2006/laile/erinlail.pdf.

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6

Knierim, Tika L. "The photodegradation of domoic acid and the effects of metal chelation /." Electronic version (PDF), 2005. http://dl.uncw.edu/etd/2005/knierimt/tikaknierim.html.

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7

Wittmaack, Christiana. "Behavioral Criteria for the Diagnosis of Domoic Acid Toxicosis in Zalophus californianus." NSUWorks, 2014. http://nsuworks.nova.edu/occ_stuetd/143.

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Introduction California sea lion (Zalophus californianus) health is severely compromised by domoic acid toxicosis, which occurs in high levels during harmful algal blooms of Pseudonitzschia australis along the coast of California. Current diagnostic protocols are often inconclusive due to a 2-48 hour window of detectability within the urinary, circulatory, and gastric systems (Cook, et al. 2011 and Monte, Pers Comm, 2012). Past studies suggest that Z. californianus, with domoic acid toxicosis, commonly display abnormal behaviors (Goldstein, et al. 2008). However, many of these abnormal behavio

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8

Vranyac-Tramoundanas, Alexandra, and n/a. "Domoic acid-induced cardiac damage : an in vitro and in vivo investigation." University of Otago. Department of Pharmacology & Toxicology, 2007. http://adt.otago.ac.nz./public/adt-NZDU20071012.143651.

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Cardiovascular pathology is seen in both animals and humans after domoic acid intoxication. Whether this damage is direct (i.e., cardiotoxic) or indirect (i.e., CNS/autonomic seizures) is not known. We have previously shown that acute in vitro domoic acid (0.05-0.25[mu]M; 10 min) treatment of isolated cardiac mitochondria compromises mitochondrial FADH and NAD⁺-linked respiratory control and mitochondrial energetics. Domoic acid was shown to traverse and bind the cellular membrane of H9c2 cardiac myoblasts. However it did not compromise cellular viability as assessed using cell quantification

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9

Hesp, Blair, and n/a. "In vitro and In vivo investigations of tolerance induction and the role of G-protein coupled kainate receptors." University of Otago. Department of Pharmacology & Toxicology, 2005. http://adt.otago.ac.nz./public/adt-NZDU20070503.150053.

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The excitotoxin domoic acid (DOM) acts at both kainic acid (KA)- and α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)-sensitive glutamate receptors. Clinical reports suggest that elderly people are hypersensitive to the neurological effects of DOM intoxication. Young, but not aged hippocampal slices which have been preconditioned with low concentrations of DOM or KA exhibit an acute �tolerance� to subsequent high doses of DOM or KA; application of the selective AMPA agonist fluorowillardiine (FW) fails to induce tolerance to excitotoxins. The aim of this study was to further investigate

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10

Fehling, Johanna. "Diversity, ecology and domoic acid production of Pseudo-nitzschia spp. in Scottish waters." Thesis, Open University, 2004. https://pure.uhi.ac.uk/portal/en/studentthesis/diversity-ecology-and-domoic-acid-production-of-pseudonitzschia-spp-in-scottish-waters(4b83d442-d9f6-4b9b-bc2f-666623b42d0b).html.

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Some diatoms of the genus Pseudo-nitzschia produce the toxin domoic acid (DA). Accumulation of DA in shellfish has led to harvesting closures in western Scottish waters since 1999. This thesis investigated the diversity, ecology and distribution of toxic and non-toxic Pseudo-nitzschia species in western Scottish waters and physiological aspects of growth and toxin production dynamics of P. seriata. The temporal and spatial distribution of phytoplankton was analysed in two separate field studies. 1) Temporal changes were followed by sampling a site in coastal Scottish waters weekly to fortnight

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11

McCollough, Bianca. "Toxic algae and other marine biota: detection, mitigation, prevention and effects on the food industry." Kansas State University, 2016. http://hdl.handle.net/2097/32490.

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Master of Science<br>Food Science Institute<br>Curtis Kastner<br>Harmful Algal Blooms (HABs) including Cyanobacteria and other toxic marine biota are responsible for similar harmful effects on human health, food safety, ecosystem maintenance, economic losses and liability issues for aquaculture farms as well as the food industry. Detection, monitoring and mitigation are all key factors in decreasing the deleterious effects of these toxic algal blooms. Harmful algal blooms can manifest toxic effects on a number of facets of animal physiology, elicit noxious taste and odor events and cause mas

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12

Armstrong, Howard Meredith Dana Armstrong Howard Meredith Dana. "Harmful algal blooms on the U.S. west coast : new insights into domoic acid production and identification of yessotoxin, a new marine toxin detected in California coastal waters /." Digital Dissertations Database. Restricted to UC campuses, 2007. http://uclibs.org/PID/11984.

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13

GIULIETTI, SONIA. "Unveiling the hidden biodiversity of potentially toxic diatoms in the NW Adriatic Sea through integrated taxonomy approach." Doctoral thesis, Università Politecnica delle Marche, 2021. http://hdl.handle.net/11566/289742.

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Pseudo-nitzschia è tra i generi di diatomee più noti e studiati, poiché tra tutte le 56 specie accettate, 26 sono in grado di produrre una neurotossina (acido domoico) responsabile di una biointossicazione (Amnesic Shellfish Poisoning) nell’uomo. La diversità e l’andamento stagionale delle specie di Pseudo-nitzschia sono stati analizzati per la prima volta nella stazione costiera del transetto Senigallia-Susak (LTER) nel NW Adriatico dal 1988 al 2020, attraverso un approccio tassonomico integrato basato su analisi ultrastrutturale e molecolare. Almeno 6 morfotipi sono stati identificati tramit

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14

Polischuk, Trevor M. "Intrinsic optical signals characterizing acute excitotoxicity in the hippocampal slice evoked by the marine toxin domoic acid." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq20581.pdf.

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15

Panlilio, Jennifer Martinez. "Impacts of developmental exposures to the harmful algal bloom toxin domoic acid on neural development and behavior." Thesis, Massachusetts Institute of Technology, 2019.

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This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Thesis: Ph. D., Joint Program in Oceanography/Applied Ocean Science and Engineering (Massachusetts Institute of Technology, Department of Biology; and the Woods Hole Oceanographic Institution), 2019<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references.<br>Harmful algal blooms (HABs) can produce potent neurotoxins that accumulate in seafood and affect human health. One HAB toxin of concern is domoic acid

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16

Vigilant, Veronica Lynn. "The occurrence of the harmful algae bloom toxin, domoic acid, in nearshore and offshore benthic communities of Monterey Bay, California /." Diss., Digital Dissertations Database. Restricted to UC campuses, 2007. http://uclibs.org/PID/11984.

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17

Downes-Tettmar, Naomi. "Factors that impact Pseudo-nitzschia spp. occurrence, growth, and toxin production." Thesis, University of Plymouth, 2013. http://hdl.handle.net/10026.1/1588.

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This work investigates, for the first time, the Pseudo-nitzschia (PN) dynamics in the western English Channel (L4) and the environmental factors impacting on domoic acid (DA) production in these waters. This is combined with laboratory studies examining key environmental factors and the multifactorial impact of multiple macronutrient and micronutrient availability on PN growth and DA production. An LC-MS method was established, optimised, and compared with ELISA for the accurate and reproducible extraction and determination of particulate and dissolved DA. The method was used to measure the se

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18

Rieseberg, Ashley. "Holistic approach to the evaluation of the anthropocentric influence on domoic acid production and the corresponding impact on the California Sea Lion (Zalophus californianus) population." Thesis, Uppsala universitet, Institutionen för geovetenskaper, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-179182.

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Domoic acid (DA) is a neurotoxin produced by the harmful algae Pseudo-nitzschia that has been directly linked to mass stranding events of the California Sea Lion (CSL). The purpose of this paper is to review the anthropogenic influence on the production of this neurotoxin and examine how human activities are impacting this marine mammal species. A comprehensive and interdisciplinary literature review was conducted to evaluate the future sustainability of the CSL population. It was found that while Pseudo-nitzschia bloom developments are vulnerable to anthropogenic influences, the incontestable

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19

Deléglise, Margot. "Suivi de la contamination des coquilles Saint-Jacques (Pecten maximus) par l'acide domoïque et exploration du rôle du microbiote dans sa décontamination." Electronic Thesis or Diss., Brest, 2024. http://www.theses.fr/2024BRES0022.

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La coquille Saint-Jacques {Pecten maximus) fait figure d’exception parmi les organismes contaminés par l’acide domoïque du fait de sa longue rétention au sein de sa glande digestive. Bien que les interdictions de pêche en cas de contamination aient un impact économique important, le mécanisme sous-jacent à cette lente dépuration reste méconnu. Les objectifs de cette thèse ont donc été de i) examiner in situ la contamination de P. maximus en corrélation avec la présence de Pseudo-nitzschia spp. et d’acide domoïque dans l'eau afin d'identifier les diverses sources de contamination possibles, ii)

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20

Howard, Meredith Dana Armstrong. "Harmful algal blooms on the U.S. west coast : new insights into domoic acid production and identification of yessotoxin, a new marine toxin detected in California coastal waters /." Diss., Digital Dissertations Database. Restricted to UC campuses, 2007. http://uclibs.org/PID/11984.

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21

Sauvey, Aurore. "Variabilité interspécifique et intraspécifique des indices physiologiques chez les diatomées toxiques du genre Pseudo-nitzschia : influence du cycle de vie." Thesis, Normandie, 2018. http://www.theses.fr/2018NORMC266/document.

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Chez les diatomées du genre Pseudo-nitzschia, certaines espèces produisent une neurotoxine, l’acide domoïque responsable chez l’homme d’intoxications amnésiantes suite à la consommation de mollusques contaminés. En Baie de Seine, la variabilité interannuelle de ces efflorescences toxiques, qui provoquent certaines années des fermetures de zones de pêche à la coquille Saint-Jacques, est liée à des changements de diversité spécifique au sein des communautés de Pseudo-nitzschia. Cette thèse avait pour objectif de caractériser la diversité écophysiologique au sein du genre Pseudo-nitzschia afin de

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22

Deschler, Marie. "Ιntéractiοns et cοmmunicatiοn chimique entre les diatοmées tοxiques du genre Ρseudο-nitzschia et les cοnsοmmateurs zοοplanctοniques". Electronic Thesis or Diss., Normandie, 2024. http://www.theses.fr/2024NORMLH13.

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Les efflorescences d’algues toxiques (HAB), potentiellement favorisées par le réchauffement climatique et l’eutrophisation des écosystèmes côtiers, est un sujet de préoccupation majeur. C’est le cas des diatomées du genre Pseudo-nitzschia, dont certaines espèces produisent une neurotoxine, l’acide domoïque (AD), responsable d'intoxication amnésiante par les mollusques (ASP). Ces efflorescences ont des conséquences à la fois sanitaires et socio-économiques, les phénomènes ASP entrainant des interdictions de pêche, en particulier à la coquille Saint Jacques sur les côtes normandes. Les copépodes

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23

Delegrange, Alice. "Impact du phytoplancton sur les juvéniles de bars (Dicentrarchus labrax) en milieu aquacole : approches in situ et expérimentales." Thesis, Littoral, 2015. http://www.theses.fr/2015DUNK0518.

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Dans une ferme d'élevage de bar (Dicentrarchus labrax) du sud de la mer du Nord, de fortes mortalités de bar coïncident régulièrement avec l'efflorescence phytoplanctonique printanière. Le rôle du phytoplancton dans ces mortalités a donc été étudié : un suivi saisonnier (février-novembre 2012) a permis de définir les communautés phytoplanctoniques en présence et, la diversité et la toxicité du genre Pseudo-nitzschia. Ainsi, trois espèces potentiellement toxiques ont été identifiées (P. delicatissima, P. pungens, P. fraudulenta) en association avec des concentrations élevées d'acide domoïque (j

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24

O'dea, Sheila. "Occurrence, Toxicity, and Diversity of Pseudo-nitzschia in Florida Coastal Waters." Scholar Commons, 2012. http://scholarcommons.usf.edu/etd/4187.

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Domoic acid (DA), a potent neurotoxin that has the potential to cause amnesic shellfish poisoning (ASP), is produced by members of the marine diatom genus Pseudo-nitzschia. Outbreaks of ASP in humans and of DA poisoning in birds and marine mammals have been reported across the United States and Canada since the late 1980's. Pseudo-nitzschia species can be extremely abundant in Florida waters, with densities often exceeding 106 cells/L, and sometimes exceeding 107 cells/L. Based on preliminary data, it is evident that at least nine species of Pseudo-nitzschia are found in Florida coastal waters

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25

Li, Ran. "Signal peptide prediction in the space-frequency domain." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file 0.44 Mb., 68 p, 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:1432421.

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26

Gadhavi, Paresh Laxman. "The structure of the DNA-binding domain of GAL4." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240924.

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27

Martinez, Sarah Jane. "Strategies for preparing segmentally isotopically labeled proteins for probing domain-domain interactions by FTIR spectroscopy by Sarah Jane Martinez." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=82290.

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Fourier transform infrared (FTIR) spectroscopy is a powerful tool for probing protein structure-function relationships. With the use of isotope editing, it can also be employed to elucidate protein-nucleic acid interactions. This technique was used to study the sequence of heat-induced unfolding of the uniformly labeled 13C regulatory subunit (RSU) of E. coli aspartate transcarbamylase (ATCase) with its inhibitor CTP. The absorption of CTP in the amide I' region limits our ability to detect protein conformational changes upon binding of CTP. Therefore, by labeling the protein with 13C s

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28

Sekharan, Monica R. "Structural studies of the cGMP-binding GAF domain of PDE5A /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/8502.

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29

Lutya, Portia Thandokazi. "Expression and purification of the novel protein domain DWNN." Thesis, University of the Western Cape, 2002. http://etd.uwc.ac.za/index.php?module=etd&amp.

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Proteins play an important role in cells, as the morphology, function and activities of the cell depend on the proteins they express. The key to understanding how different proteins function lies in an understanding of the molecular structure. The overall aim of this thesis was the determination of the structure of DWNN domains. This thesis described the preparation of samples of human DWNN suitable for structural analysis by nuclear magnetic resonance spectroscopy (NMR), as well as NMR analysis.

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30

Hufnagle, David C. "THE ANALYSIS OF BIOLOGICAL COMPOUNDS AND THREAT AGENTS WITH TERAHERTZ TIME-DOMAIN SPECTROSCOPY AND IMAGING." Miami University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=miami1354282849.

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31

Sirota, Leite Fernanda. "Role of the amino acid sequences in domain swapping of the B1 domain of protein G by computation analysis." Doctoral thesis, Universite Libre de Bruxelles, 2007. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210657.

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Domain swapping is a wide spread phenomenon which involves the association between two or more protein subunits such that intra-molecular interactions between domains in each subunit are replaced by equivalent inter-molecular interactions between the same domains in different subunits. This thesis is devoted to the analysis of the factors that drive proteins to undergo such association modes. The specific system analyzed is the monomer to swapped dimer formation of the B1 domain of the immunoglobulin G binding protein (GB1). The formation of this dimer was shown to be fostered by 4 amino acid

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32

Seyedhosseini, Ensieh. "Piezoelectricity and ferroelectricity in amino acid glycine." Doctoral thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/15169.

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Doutoramento em Nanociências e Nanotecnologia<br>Bioorganic ferroelectrics and piezoelectrics are becoming increasingly important in view of their intrinsic compatibility with biological environment and biofunctionality combined with strong piezoelectric effect and switchable polarization at room temperature. Here we study piezoelectricity and ferroelectricity in the smallest amino acid glycine, representing a broad class of non-centrosymmetric amino acids. Glycine is one of the basic and important elements in biology, as it serves as a building block for proteins. Three polymorphic forms wit

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33

Rauch, Steven Martin. "Critical Amino Acids of the Ga2 Subunit Helical Domain in Dictyostelium discoideum." Fogler Library, University of Maine, 2002. http://www.library.umaine.edu/theses/pdf/RauchSM2002.pdf.

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34

Parker, Maura H. "Characterization of the native and iron-replaced DNA-binding domain of the retinoic acid receptor." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1996. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ51580.pdf.

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35

Arpino, James. "From single amino acid deletions to whole domain insertions : engineering GFP through polypeptide backbone mutations." Thesis, Cardiff University, 2011. http://orca.cf.ac.uk/14266/.

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With an ever-expanding protein engineering toolbox different mutational techniques can be used to engineer new or altered function into protein scaffolds without the restriction of sampling just simple substitution mutagenesis. These include approaches that target backbone as well as side chain changes, such as single amino acid deletions or whole domain insertion. The problem with utilizing these mutational approaches is the difficulty in predicting both local and global structural changes on changing the backbone conformation. The aim of this thesis is to demonstrate the tolerance and benefi

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36

Reed, Michelle Anne Cole. "NMR studies on the acyl carrier protein domain from the type I rat fatty acid synthase." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326271.

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Poshtiban, Anahita [Verfasser]. "Gating modules of the AMPA receptor pore domain revealed by unnatural amino acid mutagenesis / Anahita Poshtiban." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2020. http://d-nb.info/1218075902/34.

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Levine, Kara B. "Identification of the Human Erythrocyte Glucose Transporter (GLUT1) ATP Binding Domain: A Dissertation." eScholarship@UMMS, 1999. https://escholarship.umassmed.edu/gsbs_diss/247.

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The human erythrocyte glucose transport protein (GLUT1) interacts with, and is regulated by, cytosolic ATP. This study asks the following questions concerning ATP modulation of GLUT1 mediated sugar transport. 1) Which region(s) of GLUT1 form the adenine nucleotide-binding domain? 2) What factors influence ATP modulation of sugar transport? 3) Is ATP interaction with GLUT1 sufficient for sugar transport regulation? The first question was addressed through peptide mapping, n-terminal sequencing, and alanine scanning mutagenesis of GLUT1 using [32P]-azidoATP, a photoactivatable ATP analog. We the

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Phillips, Kyle. "Characterization of the role of Zea mays burp domain-containing genes in maize drought responses." Thesis, University of the Western Cape, 2016. http://hdl.handle.net/11394/5339.

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Philosophiae Doctor - PhD<br>Global climate change has resulted in altered rainfall patterns, causing annual losses in maize crop yield due to water deficit stress. Therefore, it is important to produce maize cultivars which are more drought-tolerant. This not an easily accomplished task as plants have a plethora of physical and biochemical adaptation methods. One such mechanism is the drought-induced expression of enzymatic and non-enzymatic proteins which assist plants to resist the effects of water deficit stress. The RD22-like protein subfamily is expressed in response to water deficit str

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Taulbee, Anita R. "Terahertz Time-Domain Spectroscopy and Imaging of Biological Compounds and Tissues." Miami University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=miami1249412289.

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Sen, Gulseren Petek. "Fabrication Of Poly (dl-lactic-co-glycolic Acid) Nanoparticles And Synthetic Peptide Drug Conjugate For Anti-cancer Drug Delivery." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/12611405/index.pdf.

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Cancer is a group of diseases in which normal cells are converted to cells capable of autonomous growth and invasion. In the chemotherapeutic control of cancer, drugs are usually given systemically so they reach toxic levels in healthy cells as well as cancer cells. This causes serious side effects. Another important problem with chemotherapy is resistance developed to cytotoxic drugs (multi drug resistance). Doxorubicin (Dox) occupies a central position in the treatment of breast cancer. However doxorubicin induced cardiac toxicity is associated with a high incidence of morbidity and mortali

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Barbaro, Elena <1985&gt. "Tossine in matrici ambientali : quantificazione mediante metodi accoppiati HPLC/MS ad elevata sensibilità." Doctoral thesis, Università Ca' Foscari Venezia, 2013. http://hdl.handle.net/10579/2998.

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Lo scopo di questa tesi dottorato consiste nello sviluppo e nella convalida di metodi analitici HPLC-MS/MS, volti alla determinazione di tossine algali in diverse matrici ambientali. In particolare l’attenzione si è focalizzata sulle tossine algali d’acqua dolce, le cianotossine, e una tossina marina, l’acido domoico, andando a sviluppare delle procedure pre-analitiche per la determinazione di queste sostanze in tre diversi comparti ambientali: il comparto idrico, dove queste sostanze vengono emesse, i molluschi, organismi che ne possono essere contaminati, e l’aerosol atmosferico, al fine di

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43

Thele, Marc. "A contribution to the modelling of the charge acceptance of lead-acid batteries - using frequency and time domain based concepts." Aachen Shaker, 2007. http://d-nb.info/991509978/04.

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Christianson, Carl Victor. "Understanding The Biosynthesis And Utilization Of Non-Proteinogenic Amino Acids For The Production Of Secondary Metabolites In Bacteria." Thesis, Boston College, 2008. http://hdl.handle.net/2345/967.

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Thesis advisor: Steven D. Bruner<br>Bacteria utilize complex enzymatic machinery to create diverse secondary metabolites. The architectural complexities of these small molecules are enhanced by nature’s ability to synthesize non-proteinogenic amino acids for incorporation into these scaffolds. Many of these natural products are utilized as therapeutic agents, and it would be advantageous to understand how the bacteria create various non-natural amino acid building blocks. With a greater understanding of these systems, engineering could be used to create libraries of potentially useful natural

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Lizée, Gregory Anthony. "MHC class I cytoplasmic domain, defining a role for conserved amino acid residues in class I expression, trafficking, and antigen presentation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0020/NQ56582.pdf.

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Klyashtornyy, Vladislav. "Principles of protein nucleic acid : recognition on the examples of the ribosomal protein L1 and the cold shock domain of YB-1 protein." Thesis, Evry-Val d'Essonne, 2012. http://www.theses.fr/2011EVRY0039/document.

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Cette thèse est une étude structurale sur l’interaction entre 2 protéines modèles et des acides nucléiques : la protéine L1 (navette ribosome/ARN messagers) et le sous domaine CSD de YB-1, protéine régulatrice de la transcription et traduction. Deux méthodes sont utilisées : i) diffraction des RX par des cristaux de complexes L1:ARN ribosomal ou messager et ii) modélisation et dynamique moléculaire pour l’interaction CSD avec des homo-ribo- ou homo-deoxyribo-nucléotides simple brin. Les méthodes sont décrites avec leurs forces et limites. Les résultats sur L1-rARN/ARN éclairent les mécanismes

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47

Thele, Marc [Verfasser]. "A contribution to the modelling of the charge acceptance of lead-acid batteries – using frequency and time domain based concepts / Marc Thele." Aachen : Shaker, 2008. http://d-nb.info/1161306323/34.

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48

Matthews, Sam S. "Investigation into the Effects of PEGylation on the Thermodynamic Stability of the WW Domain." BYU ScholarsArchive, 2013. https://scholarsarchive.byu.edu/etd/4280.

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The covalent attachment of poly(ethylene glycol) (PEG) to a protein surface (known as PEGylation), has been demonstrated to increase the serum half-life of therapeutic proteins by reducing kidney clearance and immunogenicity and by protecting against proteolysis. Theses beneficial effects could be further enhanced if PEGylation consistently increased protein conformational stability (i.e. the difference in free energy between the folded and unfolded states). However, the effects of PEGylation on protein conformational stability are unpredictable; PEGylation has been reported to increase, decre

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Annoni, C. "NEW DIMENSIONS INTO PROTEIN-NUCLEIC ACIDS INTERACTIONS." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/232405.

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In the late 19th century, scientists microscopically observed the association of proteins with DNA strands. Since then, researchers have used a variety of in vitro and in vivo assays to demonstrate that proteins interact with DNA and RNA to influence the structure and function of the corresponding nucleic acid. Elucidating the roles that protein-nucleic acid complexes play in the regulation of transcription, translation, DNA replication, repair and recombination and RNA processing and translocation continues to revolutionize our understanding of cell biology, normal cell development and the me

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Max, Klaas. "Structural and functional studies on bacterial cold shock proteins nucleic-acid binding, the architecture of a domain swap, and mechanisms contributing to their stabilization /." kostenfrei, 2007. http://www.diss.fu-berlin.de/2007/25/index.html.

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