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Popović, Mladen. "Reading the human body : physiognomics and astrology in the Dead Sea scrolls and Hellenistic - early Roman period Judaism /." Leiden ; Boston : Brill, 2007. http://public.eblib.com/EBLPublic/PublicView.do?ptiID=468334.
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KARIMSHOUSHTARI, MILAD. "Design of Experiments for Nonlinear System Identification." Doctoral thesis, Politecnico di Torino, 2019. http://hdl.handle.net/11583/2751496.
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Cruz, Cláudia Amaral [UNESP]. "Produtividade e rendimento industrial do milho doce irrigado em função de dose e parcelamento de nitrogênio." Universidade Estadual Paulista (UNESP), 2014. http://hdl.handle.net/11449/113771.
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000800510.pdf: 372835 bytes, checksum: 7b40f55abaab440005774f9f472d99e9 (MD5)O Brasil apresenta elevado potencial para produção de milho doce e diferentemente do milho ainda há escassez de informações técnicas. Com o objetivo de avaliar o efeito da adubação nitrogenada no rendimento industrial e produtividade do milho doce irrigado desenvolveu-se um experimento em Guaíra - SP, no período de 22-4 a 15-8 de 2013, em Latossolo Acriférrico. O experimento foi instalado sob delineamento de blocos casualizados, em esquema fatorial 6 x 2, com três repetições. Os tratamentos consistiram em seis doses de N (0, 60, 120, 180, 240 e 300 kg ha-1), na fonte uréia, aplicadas em duas formas de parcelamentos (P1 - 0, 7, 14, 21, 28, 35, 42 e 49 dias após a semeadura (DAS) e P2 - 0, 14, 28 e 42 DAS). Estes períodos corresponderam à aplicação de N na semeadura e nos estádios fenológicos VE,V3,V5,V7,V9,V12 e V14 (P1) e semeadura e nos estádios fenológicos V3,V7 e V12 (P2). Máximas produtividades de espigas totais e comerciais do milho doce ‘GSS 41240’ são obtidas com 300 kg ha-1 de N. A aplicação do adubo nitrogenado em oito ou quatro vezes não afetou a produtividade e o rendimento industrial do milho doce. O maior rendimento industrial, 0,293 kg de grãos para 1 kg de espigas é obtido aplicando-se 188 kg ha-1 de N
The Brazil has hight potencial for producer sweet and unlike corn, there is little technical information. Aiming to evaluate the effect of nitrogen fertilization on productivity and industrial yield of sweet corn irrigated was developed an experiment in Guaíra, Brazil, in 04-22 to 08-15 of the 2013. The experimental design was a randomized blocks, in factorial design (6X2) with three replications. The treatments corresponding to six N dosage (0, 60, 120, 180, 240 and 300 kg ha- 1) and two ways of subdivisions: 0, 7,14, 21, 28, 35, 42 and 49 days after sowing (DAS) and 0,14, 28 and 42 DAS. These application times corresponded to vegetative stages, with application at sowing, VE, V3, V5 , V7, V9, V12 and V14 (eight subdivision) and seeding, V3, V7 and V12 (four subdivision), respectively. Maximum total and commercial cobs productivity of sweet corn, hybrid 'GSS 41240' are obtained with 300 kg ha-1of N. The largest number of nitrogen subdivisions does not contribute to increasing the productivity and industrial yield. The largest industrial yield, 0,293 kg of the grain by 1 kg of the cobs is obtained by applying of 188 kg ha-1 N
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Cruz, Cláudia Amaral. "Produtividade e rendimento industrial do milho doce irrigado em função de dose e parcelamento de nitrogênio /." Jaboticabal, 2014. http://hdl.handle.net/11449/113771.
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Orientador: Arthur Bernardes Cecílio FilhoBanca: Manoel Evaristo Ferreira
Banca: Maria Zuleide de Negreiros
Resumo: O Brasil apresenta elevado potencial para produção de milho doce e diferentemente do milho ainda há escassez de informações técnicas. Com o objetivo de avaliar o efeito da adubação nitrogenada no rendimento industrial e produtividade do milho doce irrigado desenvolveu-se um experimento em Guaíra - SP, no período de 22-4 a 15-8 de 2013, em Latossolo Acriférrico. O experimento foi instalado sob delineamento de blocos casualizados, em esquema fatorial 6 x 2, com três repetições. Os tratamentos consistiram em seis doses de N (0, 60, 120, 180, 240 e 300 kg ha-1), na fonte uréia, aplicadas em duas formas de parcelamentos (P1 - 0, 7, 14, 21, 28, 35, 42 e 49 dias após a semeadura (DAS) e P2 - 0, 14, 28 e 42 DAS). Estes períodos corresponderam à aplicação de N na semeadura e nos estádios fenológicos VE,V3,V5,V7,V9,V12 e V14 (P1) e semeadura e nos estádios fenológicos V3,V7 e V12 (P2). Máximas produtividades de espigas totais e comerciais do milho doce 'GSS 41240' são obtidas com 300 kg ha-1 de N. A aplicação do adubo nitrogenado em oito ou quatro vezes não afetou a produtividade e o rendimento industrial do milho doce. O maior rendimento industrial, 0,293 kg de grãos para 1 kg de espigas é obtido aplicando-se 188 kg ha-1 de N
Abstract: The Brazil has hight potencial for producer sweet and unlike corn, there is little technical information. Aiming to evaluate the effect of nitrogen fertilization on productivity and industrial yield of sweet corn irrigated was developed an experiment in Guaíra, Brazil, in 04-22 to 08-15 of the 2013. The experimental design was a randomized blocks, in factorial design (6X2) with three replications. The treatments corresponding to six N dosage (0, 60, 120, 180, 240 and 300 kg ha- 1) and two ways of subdivisions: 0, 7,14, 21, 28, 35, 42 and 49 days after sowing (DAS) and 0,14, 28 and 42 DAS. These application times corresponded to vegetative stages, with application at sowing, VE, V3, V5 , V7, V9, V12 and V14 (eight subdivision) and seeding, V3, V7 and V12 (four subdivision), respectively. Maximum total and commercial cobs productivity of sweet corn, hybrid 'GSS 41240' are obtained with 300 kg ha-1of N. The largest number of nitrogen subdivisions does not contribute to increasing the productivity and industrial yield. The largest industrial yield, 0,293 kg of the grain by 1 kg of the cobs is obtained by applying of 188 kg ha-1 N
Mestre
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Caputo, Marina Maitto. "Avaliação de doze cultivares de laranja doce de maturação precoce na região sudoeste do Estado de São Paulo." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/11/11136/tde-16082012-081058/.
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É restrito o número de cultivares utilizado nos pomares comerciais, embora a diversidade de gêneros, espécies, cultivares e clones de citros seja grande. No entanto, o processamento industrial baseia-se em quatro cultivares principais, a Hamlin, como precoce, a Pêra como meia estação e a Natal e Valência como tardias. Alicerçada nestas quatro cultivares, o processamento industrial de sucos utiliza-se de frutos de junho a dezembro, com maior intensidade, e até fevereiro do ano seguinte quando a oferta diminui, sendo março a maio o período da entressafra. Por esse motivo, é de extrema importância selecionar cultivares que produzam nesse período. O objetivo, este trabalho foi avaliar o desempenho horticultural de doze cultivares de laranja doce de maturação precoce e identificar aquelas superiores à laranja Hamlin, com intuito de oferecer ao citricultor da região sudoeste do Estado de São Paulo, novas opções que produzam frutos de qualidade, tanto para fruta in natura como para processamento industrial e que tenham produção antecipada. As cultivares avaliadas foram Hamlin (cultivar precoce padrão), Westin, Pineapple, Rubi, Seleta Vermelha, Mayorca, Valência 2, Olivelands, Kawatta, IAPAR 73, Salustiana e Valência Americana. O delineamento experimental foi o inteiramente casualizado, com quatro repetições, compostas por três plantas de cada cultivar. Os dados referentes ao crescimento vegetativo (altura, diâmetro de planta e volume de copa), produção e eficiência produtiva, morfologia dos frutos (massa, largura, comprimento, tamanho, espessura da casca e número de sementes) e características de qualidade interna dos frutos (SST, acidez, porcentagem de suco, ratio, índice tecnológico, ácido ascórbico, índices de cor da polpa e da casca) foram coletados. As médias foram comparadas com a cultivar padrão Hamlin e analisadas pelo teste Dunnett. Para avaliar simultaneamente as características, foram aferidos os índices de desempenho para identificar cultivares promissoras que atendessem aos requisitos tanto para o processamento industrial como para o consumo in natura. Oliverlands foi a cultivar de laranja doce que registrou maior altura de planta e volume de copa, maior produção de frutos e maior eficiência produtiva em relação a cultivar Hamlin. Para o processamento industrial, a laranja Westin apresentou alto índice de desempenho enquanto que as laranjas Valência 2 e Salustiana registraram índices de desempenho favoráveis para consumo in natura. Não foram observados cultivares de laranja doce com dupla aptidão para o processamento industrial e consumo in natura na região sudoeste do Estado de São Paulo.The number of sweet orange cultivars used in commercial orchards in Brazil is restricted, although the diversity of genera, species, cultivars and clones of citrus is great. However, the industrial processing is based on four main cultivars, the \'Hamlin\', as early maturing, the \'Pera\', as mid-season, and \'Natal\' and \'Valencia\' as late maturing cultivars. Anchored on these four cultivars, the orange juice industry processes fruits from June through December with greater intensity, January and February with lower supply, and the period from March through May is considered off season. Therefore, it is extremely important to select varieties that produce during this period. The objective of this study was to evaluate the horticultural performance of twelve early maturing sweet orange cultivars and identify those better than the \'Hamlin\' sweet orange, aiming to offer new options for producing fruits with quality, as for fresh fruit market as for industrial utilization, during early citrus harvest season in the southwest region of São Paulo state. The cultivars \'Hamlin\' (early maturing standard cultivar), \'Westin\', \'Pineapple\', \'Ruby\', \'Seleta Vermelha\', \'Mayorca\', \'Valencia 2\', \'Oliverlands\', \'Kawatta\', \'IAPAR 73\', \'Salustiana\' and \'Valencia Americana\' were evaluated. The experimental design was completely randomized with four replications, consisting of three plants of each cultivar per plot. Data concerning vegetative growth (plant height, stem diameter and canopy volume), production and yield efficiency, fruit morphology (mass, width, length, size, shell thickness and number of seeds) and the characteristics of internal fruit quality (total soluble solids, acidity, percentage of juice, \"ratio\", technological index, ascorbic acid, color indexes of pulp and peel) were collected The averages were compared to \'Hamlin\' sweet orange (standard cultivar) and analyzed by Dunnett test. To evaluate the characteristics simultaneously, performance indexes were estimated for identifying promising cultivars for utilization as for juice industry as for consumption fresh fruit market. \'Oliverlands\' was the sweet orange cultivar which showed higher plant height and plant volume, higher production and yield efficiency as compared to \'Hamlin\' sweet orange. The cultivar \'Westin\' showed higher performance index for the industrialization process, whereas \'Valencia 2\' and \'Salustiana\' sweet oranges had adequate performance indexes for fresh fruit market. There was no cultivar of sweet orange that had the simultaneous ability for the juice industry and for fresh fruit market in the southwestern region of Sao Paulo state.
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Li, Zezheng. "Estimating Minimum Effective Dose in Dose Response Studies." Fogler Library, University of Maine, 2009. http://www.library.umaine.edu/theses/pdf/LiZ2009.pdf.
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Ibaceta, Ibaceta Cristian. "Pájaro dodo." Tesis, Universidad de Chile, 2011. http://www.repositorio.uchile.cl/handle/2250/101315.
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“Pájaro Dodo” es una acción de arte producida para un entorno virtual. Ha sido realizada para y mediante cuentas Facebook y Youtube. La manipulación artística de estas cuentas electrónicas es realizada mediante técnicas de publicidad y marketing digital. “Pájaro Dodo” es producto de una reflexión artística sobre la utilización del sistema de redes sociales manipulando el gran caudal informacional que circula en Internet. Para tales efectos, “Pájaro Dodo” ha sido diseñado como un personaje, un avatar, donde el nombre que lo identifica es el de un pájaro que metaforiza tanto las campañas publicitarias digitales absurdas como las operaciones artísticas sin sentido dadaístas y surrealistas. “Pájaro Dodo” es una obra que funciona por Internet y que puede ser vista desde cualquier lugar, siempre y cuando exista conectividad.
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Chamberlain, Peter. "Moaning like a dove : Isaiah's dove texts as the background to the dove in Mark 1:10." Thesis, University of St Andrews, 2016. http://hdl.handle.net/10023/7916.
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There is no consensus regarding the interpretation of the "Spirit like a dove" comparison in Jesus' baptism (Mk 1:10). Although scholars have proposed at least fifty different interpretations of the dove comparison, no study appears to have considered Isaiah's three dove texts as the background for the Markan dove (cf. Is 38:14; 59:11; 60:8). This neglect is surprising considering the abundance of Isaianic allusions in Mark's Prologue (Mk 1:1-15), and the growing awareness that Isaiah is the hermeneutical key for both the Markan Prologue and Jesus' baptism within it. Indeed, Mark connects the dove image inseparably to the Spirit's "descent" from heaven, which alludes to Yahweh's descent in a New Exodus deliverance in Isaiah 63:19 [MT]. Furthermore, each Isaianic dove text uses the same simile, "like a dove" or "like doves," which appears in Mark 1:10, and shares the theme of lament and restoration which fits the context of Mark's baptism account. This study therefore argues that the dove image in Mark 1:10 is a symbol which evokes metonymically Isaiah's three dove texts. So the Spirit is "like a dove" not because any quality of the Spirit resembles that of a dove, but because the dove recalls the Isaianic theme of lament and restoration associated with doves in this Scriptural tradition. After discussing the Markan dove in terms of simile, symbol, and metonymy, the study examines the Isaianic dove texts in the MT and LXX and argues that they form a single motif. Next, later Jewish references to the Isaianic dove texts are considered, while an Appendix examines further dove references in Jewish and Greco-Roman literature. Finally, the study argues that the Markan dove coheres in function with the Isaianic dove motif and symbolizes the Spirit's effect upon and through Jesus by evoking metonymically the Isaianic dove texts.
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Morén, Björn. "Mathematical Modelling of Dose Planning in High Dose-Rate Brachytherapy." Licentiate thesis, Linköpings universitet, Optimeringslära, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-154966.
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Cancer is a widespread type of diseases that each year affects millions of people. It is mainly treated by chemotherapy, surgery or radiation therapy, or a combination of them. One modality of radiation therapy is high dose-rate brachytherapy, used in treatment of for example prostate cancer and gynecologic cancer. Brachytherapy is an invasive treatment in which catheters (hollow needles) or applicators are used to place the highly active radiation source close to or within a tumour. The treatment planning problem, which can be modelled as a mathematical optimization problem, is the topic of this thesis. The treatment planning includes decisions on how many catheters to use and where to place them as well as the dwell times for the radiation source. There are multiple aims with the treatment and these are primarily to give the tumour a radiation dose that is sufficiently high and to give the surrounding healthy tissue and organs (organs at risk) a dose that is sufficiently low. Because these aims are in conflict, modelling the treatment planning gives optimization problems which essentially are multiobjective. To evaluate treatment plans, a concept called dosimetric indices is commonly used and they constitute an essential part of the clinical treatment guidelines. For the tumour, the portion of the volume that receives at least a specified dose is of interest while for an organ at risk it is rather the portion of the volume that receives at most a specified dose. The dosimetric indices are derived from the dose-volume histogram, which for each dose level shows the corresponding dosimetric index. Dose-volume histograms are commonly used to visualise the three-dimensional dose distribution. The research focus of this thesis is mathematical modelling of the treatment planning and properties of optimization models explicitly including dosimetric indices, which the clinical treatment guidelines are based on. Modelling dosimetric indices explicitly yields mixedinteger programs which are computationally demanding to solve. The computing time of the treatment planning is of clinical relevance as the planning is typically conducted while the patient is under anaesthesia. Research topics in this thesis include both studying properties of models, extending and improving models, and developing new optimization models to be able to take more aspects into account in the treatment planning. There are several advantages of using mathematical optimization for treatment planning in comparison to manual planning. First, the treatment planning phase can be shortened compared to the time consuming manual planning. Secondly, also the quality of treatment plans can be improved by using optimization models and algorithms, for example by considering more of the clinically relevant aspects. Finally, with the use of optimization algorithms the requirements of experience and skill level for the planners are lower. This thesis summary contains a literature review over optimization models for treatment planning, including the catheter placement problem. How optimization models consider the multiobjective nature of the treatment planning problem is also discussed.
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do, Socorro Rocha da Silva Maria. "Estudo dosimétrico em cardiologia intervencionista: dose paciente e dose trabalhador." Universidade Federal de Pernambuco, 2011. https://repositorio.ufpe.br/handle/123456789/9305.
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Previous issue date: 2011Os avanços tecnológicos na área da geração de imagens médicas com radiações ionizantes possibilitaram a realização de intervenções invasivas que têm beneficiado diversas áreas da medicina, destacando-se entre essas as intervenções em cardiologia intervencionista. Apesar dos benefícios, os procedimentos intervencionistas geralmente envolvem o uso de longos tempos de exposição à radiação e representam, para pacientes e trabalhadores, um risco maior do que o de outros procedimentos nos quais também há exposição à radiação. Este trabalho apresenta os resultados da dosimetria realizada em médicos e pacientes (pediátricos e adultos) durante intervenções cardíacas percutâneas e procedimentos de diagnóstico, realizados no período de abril de 2007 a agosto de 2010, em um hospital de referência na cidade de Recife, Pernambuco. As medidas dosimétricas foram tomadas em 143 procedimentos, dos quais 118 foram realizados em pacientes adultos e 25 em pacientes pediátricos, estes com doença cardíaca congênita. Os procedimentos foram realizados por meio de um angiógrafo monoplanar Philips (modelo Allura 12), equipado com intensificador de imagem. A dosimetria de pacientes foi realizada pelo emprego de filmes radiocrômicos e de parâmetros de indicação de dose apresentados pelo equipamento angiográfico; e para a dosimetria nos médicos se utilizaram dosímetros termoluminescentes distribuídos no corpo e nas vestimentas de proteção dos profissionais. Durante os procedimentos clínicos, foram registrados parâmetros de irradiação e informações como: número de imagens, tempo acumulado em fluoroscopia; magnitude do kerma ar cumulativo no ponto de referência IRP [Ka,r], entre outras. Os resultados da dosimetria de pacientes mostraram valores de kerma ar na superfície de entrada da pele do paciente [Ka,e], variando de 240 a 5.897 mGy, nos pacientes adultos, e de 45 a 1.079 mGy nos pacientes pediátricos. A máxima dose absorvida na superfície (MDA) da pele do paciente variou de 649 a 4.180 mGy, nos pacientes adultos, e de 214 a 487 mGy, nos pacientes pediátricos. Seguindo orientações de guias de acompanhamento de pacientes, os pacientes que apresentaram MDA maior que 3 Gy ou Ka,r maior que 5 Gy foram avaliados, pelos médicos, após 14 dias do procedimento e não se observou a ocorrência de lesões. Com relação aos médicos, a dose efetiva média por procedimento foi 5,2 μSv em procedimentos de diagnóstico com pacientes adultos e de 4,5 μSv com pacientes pediátricos. Nos procedimentos de intervenção, os valores foram 10,8 μSv e 6,4 μSv, em procedimentos com pacientes adultos e pediátricos, respectivamente. Os valores de dose equivalente por procedimento, mais altos, medidos no corpo dos médicos, foram: 922 μSv no pé esquerdo, 514 μSv no pé direito, 382 μSv nas mãos e 150 μSv nos olhos, em procedimentos com pacientes adultos. Com pacientes pediátricos, os valores foram: 123, 127, 1.188 e 224 μSv, respectivamente. A ausência de acessórios de proteção (tela e saiote pumblíferos) e EPIs específicos (óculos e luvas) são explicações para os valores altos registrados. Dependendo do número de procedimentos, as doses recebidas pelos médicos podem exceder os limites de dose anual (150 mSv para o cristalino dos olhos e 500 mSv para extremidades) estabelecidos por normas nacionais e internacionais
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Eke, Milton Adams. "Spore-dome actinomycetes." Thesis, University of Bradford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292687.
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Wang, Na. "Estimation of Extra Risk and Benchmark Dose in Dose Response Models." Fogler Library, University of Maine, 2008. http://www.library.umaine.edu/theses/pdf/WangN2008.pdf.
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OLIVEIRA, CAMILA T. de. "Desenvolvimento de uma metodologia para calibração de câmaras de ionização de placas paralelas em feixes de raios X de energia baixa em termos de dose absorvida em água." reponame:Repositório Institucional do IPEN, 2015. http://repositorio.ipen.br:8080/xmlui/handle/123456789/26083.
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Dissertação (Mestrado em Tecnologia Nuclear)
IPEN/D
Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP
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Davenport, James Michael. "An Adaptive Dose Finding Design (DOSEFIND) Using A Nonlinear Dose Response Model." VCU Scholars Compass, 2007. http://hdl.handle.net/10156/13.
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Poon, Emily Sau Chee. "Patient-specific dose calculation methods for high-dose-rate iridium-192 brachytherapy." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=86632.
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In high-dose-rate iridium-192 brachytherapy, the radiation dose received by the patient is calculated according to the AAPM Task Group 43 (TG-43) formalism. This table-based dose superposition method uses dosimetry parameters derived with the radioactive iridium source centered in a water phantom. It neglects the dose perturbations caused by inhomogeneities, such as the patient anatomy, applicators, shielding, and radiographic contrast solution.In this work, we evaluated the dosimetric characteristics of a shielded rectal applicator with an endocavitary balloon injected with contrast solution. The dose distributions around this applicator were calculated by the GEANT4 Monte Carlo (MC) code and measured by ionization chamber and GAFCHROMIC EBT film. A patient-specific dose calculation study was then carried out for 40 rectal treatment plans. The PTRAN_CT MC code was used to calculate the dose based on computed tomography (CT) images. This study involved the development of BrachyGUI, an integrated treatment planning tool that can process DICOM-RT data and create PTRAN_CT input initialization files. BrachyGUI also comes with dose calculation and evaluation capabilities.
We proposed a novel scatter correction method to account for the reduction in backscatter radiation near tissue-air interfaces. The first step requires calculating the doses contributed by primary and scattered photons separately, assuming a full scatter environment. The scatter dose in the patient is subsequently adjusted using a factor derived by MC calculations, which depends on the distances between the point of interest, the iridium source, and the body contour. The method was validated for multicatheter breast brachytherapy, in which the target and skin doses for 18 patient plans agreed with PTRAN_CT calculations better than 1%.
Finally, we developed a CT-based analytical dose calculation method. It corrects for the photon attenuation and scatter based upon the radiological paths determined by ray tracing. The scatter dose is again adjusted using our scatter correction technique. The algorithm was tested using phantoms and actual patient plans for head-and-neck, esophagus, and MammoSite breast brachytherapy. Although the method fails to correct for the changes in lateral scatter introduced by inhomogeneities, it is a major improvement over TG-43 and is sufficiently fast for clinical use.
En curiethérapies à haut débit de dose, la dose aux patients est évaluée selon le protocole AAPM Task-Group 43 (TG43), qui utilise des paramètres dosimétriques obtenues avec une source dans l'eau. Cependant, le patient, l'applicateur et le contraste ont des propriétés radiologiques différentes de l'eau; ces inhomogénéités sont donc négligées dans TG43.
Dans ce travail, nous utilisons le programme Monte Carlo (MC) GEANT4 pour évaluer les propriétés dosimétriques d'un applicateur rectal muni d'un blindage radio-protecteur et d'un ballon intra-cavitaire. Ces résultats sont confirmés par des mesures d'une chambre d'ionisation et des films GAFCHROMIC EBT. Une étude des calculs de dose a été faite avec le programme PTRAN_CT avec l'aide des images scanner de 40 patients de cancer rectal. Ceci a conduit au développement de BrachyGUI, un programme de planification de curiethérapie, capable de traiter les données DICOM-RT des patients et générer les paramètres d'entrée pour PTRAN_CT. BrachyGUI dispose d'outils de calcul, d'extraction et d'analyse de dose.
Nous proposons une nouvelle méthode de calcul qui tient compte des effets de diffusion au voisinage des interfaces tissus-air. Cette méthode calcule séparément la dose due aux photons primaires et diffusés, ensuite la composante diffusée est ajustée par un paramètre extrait des calculs MC incluant les contours du patient, la source et sa position. Nos résultats s'accordent avec une incertitude inferieure à 1% avec les calculs de dose à la surface et dans la cible effectués avec PTRAN_CT pour 18 patients en curiethérapie du sein.
Enfin, nous avons conçu une méthode analytique de calcul de dose qui incorpore l'atténuation et la diffusion des photons, et qui est basée sur les chemins radiologiques déterminées par traçage des trajectoires. Cet algorithme est validé par l'utilisation de fantômes, des données de patients traités pour divers cancers (oesophage, tête et cou), et par la curiethérapie MammoSite du sein. Bien que cette méthode ne reproduise pas bien les diffusions latérales induites par les inhomogénéités, elle représente une amélioration majeure par-rapport-à TG43 et est rapide pour une implémentation clinique.
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Lavallee, Yan. "Understanding Dome-Building Eruptions." Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-86290.
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Labra, Salinas Evelyn Solange. "Donde fenecen las almas." Tesis, Universidad de Chile, 2012. http://www.repositorio.uchile.cl/handle/2250/111824.
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CeramistaEsta propuesta visual nace desde la dísciplina de la cerámica y se centra en su significado místico; la transformación de los elementos, hecho que ha sido considerado sagrado desde los albores de esta práctica y con mucha mayor profundidad en el chamanismo y la alquimia. Tanto así que estos últimos, tienen la creencia de que todo nace y viene de una sola fuerza. Con este planteamiento calzo mi propuesta; que está ligada a la muerte y a la problemática existencialista, lo que se expresa en los ritos funerarios y los residuos corporales, ambos como respuesta a una necesidad del ser humano por conservar parte de la vida, para recordar y ser recordados. De este modo, acudo a la urna fúnebre (vasija de cerámica contenedora involutiva del difunto y también parte de su ajuar), como base para plantear cuestionamientos en torno a la disciplina. La urna en sí pasa a segundo plano y deja hablar a la materialidad cerámica, las tierras y los residuos corporales (pelo, dientes uñas y huesos), expuestos al interior de frascos de vidrio que se entrelazan con las nebulosas de estrellas, ya que comparten los mismos químicos en su composición. Desde hace unos años, los científicos vienen planteando una relación directa entre los compuestos presentes en la tierra y en el medio extraterrestre. Mi propuesta plástica es: La instalación de 26 frascos de vidrio dentro de cajas de madera donde 13 de ellos tendrán en su interior; cabello, uñas, dientes y un hueso humano, los frascos restantes contendrán diferentes componentes de la tierra, que conforman como explicaba anteriormente, parte de nuestro cuerpo y el de las estrellas. Refuerzo esta idea con la disposición de siete cajas y empleando vidrio post formado coloreados con pigmentos de sobrecubierta para vidrio, con imágenes que simulan nebulosas junto con huesos modelados en forma directa en material cerámico.
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Eriksson, Mikaela, Anna Normark, and Rebecca Oskarsson. "HappyHelper : Get it done!" Thesis, Uppsala universitet, Institutionen för informationsteknologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-297154.
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The aim of this project is to develop an application with the purpose to help students procrastinate less and plan their studies. Cellphones are a common distraction among students today and many people find procrastination on cellphones to be a major problem. The purpose of the application is to prevent procrastination and stress by turning off distractive apps during a study session as well as offering the user help in planning upcoming deadlines and examinations. The application HappyHelper provides the user features such as blocking distracting application during a certain amount of time and a calendar for organizing studies; consequently, the aim of the project is achieved. To determine whether the purpose is fulfilled or not a user survey is required and is scheduled to be executed in the near future.Målet med detta projekt är att utveckla en applikation med syfte att hjälpa studenter prokrastinera mindre och planera sina studier. Att distraheras av mobiltelefonen är ett vanligt problem bland studenter idag och många ser prokrastineringen med en mobiltelefon som ett allvarligt bekymmer. Applikationens syfte är att motverka prokrastinering och stress genom att stänga av distraherande appar under en studiesession och erbjuda användaren att planera in arbeten och examinationer. Applikationen HappyHelper erbjuder användaren att under en tidsinställd period blockera distraherande applikationer och en kalenderfunktion för att planera in sina studier; projektet uppnår därmed sitt mål. För att avgöra huruvida syftet är uppfyllt eller inte, krävs en användarundersökning som är planerad att genomföras in en snar framtid.
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Paakkulainen, Elina. "Calico Dome Women’s Centre." Thesis, Umeå universitet, Arkitekthögskolan vid Umeå universitet, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-138825.
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Alfvén, Tobias. "Bone and kidney effects from cadmium exposure : dose effect and dose response relationships /." Stockholm : Karolinska Univ. Press, 2002. http://diss.kib.ki.se/2002/91-7349-341-4.
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Adamiec, Grzegorz. "Aspects of pre-dose and other luminescence phenomena in quartz absorbed dose estimation." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325679.
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Ås, Joel. "Active dose selection and dose-response modeling for quantitative high-throughput screening (qHTS)." Thesis, Uppsala universitet, Cancerfarmakologi och beräkningsmedicin, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-300682.
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This master thesis studies the potential benefit of iterative selection of the concentrations evaluated when building mathematical dose-response curves (and response surfaces when there are two drugs) using experimental measurements. The reference alternative is to use a standard two-fold dilution series or ten-fold dilution series measured in replicates. The standard 4-parameter Hill dose-response model is used as a reference and for simulations. Models to screen for synergy between two different substances are also developed in this thesis.
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Oliveira, Janaina Tavares Goulart de Sá Belchior de. "Melhor dose e dose econômica de TBHQ nos óleos de milho e canola." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/11/11141/tde-20102003-154417/.
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O aumento da utilização de embalagens do tipo PET nos últimos anos tem feito com que produtores de óleo se preocupem com a oxidação. Neste trabalho, óleos de milho e canola isentos de antioxidante e ácido cítrico foram adicionados de diferentes concentrações de TBHQ e submetidos a testes acelerados de oxidação acelerada em estufa a 63 0 C por 120 horas e em câmara de fotoxidação por 168 horas. Foram analisados o índice de peróxido e as absortividades em 232 nm e 270 nm nestes óleos. A partir dos resultados de índice de peróxido obtidos nos óleos com as diferentes concentrações de TBHQ no teste em estufa, foram calculadas as melhores doses e doses econômicas de 119 mg/kg e 115 mg/kg TBHQ para o óleo de milho e de 116 mg/kg e 108 mg/kg TBHQ, respectivamente, para o óleo de canola em estudo. Um ensaio ao ambiente foi conduzido usando 115 mg/kg de TBHQ, para o óleo de milho e 108 mg/kg de TBHQ, para o óleo de canola, valores menores que o máximo permitido pela legislação. Ambos os óleos foram armazenados em frascos de PET por 6 meses em condições tão satisfatórias quanto quando adicionados do máximo permitido pela legislação.The increasing utilization of PET packaging in the last years in Brazil has concerned oil producers regarding oxidation. In this work, corn and canola oils, free from antioxidants and citric acid, were added of different TBHQ concentrations, and submited to accelerated (thermo and light induced) oxidation in a Schaal oven test at 63 0 C for 120 hours and in a photooxidation chamber for 168 hours. Peroxide and absorbance values at 232 nm and 270 nm were analysed in these oils. From the Schaal oven test, oil peroxide values were plotted against TBHQ concentrations and the best and the economical doses were determinated to be 119 mg/kg and 115 mg/kg TBHQ, respectively, for corn oil and 116 mg/kg and 108 mg/kg TBHQ, respectively, for canola oil. A shelf life test in PET flasks was conducted using 115 mg/kg TBHQ, for corn oil, and 108 mg/kg TBHQ, for canola oil, values that are lower than the maximum allowed by legislation and both oils were kept for 6 months.
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Revayová, Veronika. "Planetárium v Brně." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2019. http://www.nusl.cz/ntk/nusl-392086.
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The design of several variants of the structure of the planetarium in Brno is the subject of the diploma thesis . The building has a ground plan size of 30x30 meters. The main supporting material is S235 steel. The bearing structure of the object consists of columns, joists and beams. The bearing structure of the dome consists of a spatial structure, which is formed as a half-globe above the diameter of 18 meters. 3 versions of this dome have been processed. The resulting design is Geodetic Dome. Part of the work is an assessment of the main structural elements and selected details. The Scia engineer 2016 version 16.1.3033 was used to calculate internal forces.
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González, Yago. "La Technique des Débits Commutés pour l'évaluation de la dégradation à faible débit de dose des technologies bipolaires en environnement spatial." Thesis, Montpellier 2, 2010. http://www.theses.fr/2010MON20192/document.
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Avant d'approvisionner des lots de composants pour la fabrication de systèmes orbitaux, les grandes agences du spatial (CNES, ESA, NASA, JAXA…) ainsi que les industriels du spatial (EADS, Thales,…) doivent s'assurer de la fiabilité des lots proposés par les fabricants de circuits intégrés. Dans le but d'assurer la fiabilité des composants, des tests sont réalisés suivant des recommandations afin de sélectionner et trier les composants suivant leur tenue à différents modes de défaillance. Parmi tous ces tests, certains sont typiques des applications spatiales : les tests de tenue à la dose. Cette spécificité des tests de tenue à la dose de composants destinés à des applications spatiales est due au fait que l'environnement spatial est un environnement radiatif qui provoque une ionisation dans les matériaux constituant le satellite. Suite à cette ionisation des charges sont créées dans la matière et induisent des modifications au sein des matériaux qui composent les circuits intégrés, ce qui peut provoquer des dérives de leurs caractéristiques électriques. Ces dérives des paramètres électriques en environnement spatial peuvent être perçues comme un vieillissement accéléré des composants électroniques, et des tests sont donc dédiés à prédire et s'assurer du bon fonctionnement des composants même après ce vieillissement accéléré provoqué par la dose. Dans ce travail de thèse nous nous intéressons à l'applicabilité d'une technique de test accéléré des composants bipolaires développée à l'UM2: 'La technique des Débits Commutés'. Une étude de l'effet de la polarisation pendant irradiation a été mené au cours de ce travail de thèse, afin d'appréhender l'impact de la polarisation des composants bipolaires sur les estimations obtenues de façon accélérée grâce à cette techniqueBefore supplying lots of components for the manufacture of orbital systems, large space agencies (CNES, ESA, NASA, JAXA ...) and the Industrial Space (EADS, Thales, ...) should ensure the reliability lots offered by manufacturers of integrated circuits. In order to ensure reliability of components, tests are performed following recommendations to select and sort the components according to their resistance to different failure modes. Of all these tests, some are typical for space applications: tests held in the dose. The specificity of the tests held at the dose of components for space applications due to the fact that the environment is a space radiation environment which causes ionization in the materials of the satellite. Following this ionization charges are created in the material and induce changes in the materials that comprise integrated circuits, which can cause drift of their electrical characteristics. These abuses of the electrical parameters in a space environment can be viewed as accelerated aging of electronic components, and tests are dedicated to predict and verify the correct operation of the components even after the accelerated aging caused by dose. In this thesis we investigate the applicability of a technique for accelerated testing of components developed in bipolar UM2: 'The technique of Switched Flows'. A study of the effect of the polarization during irradiation was conducted during this thesis, to understand the impact of the polarization of the bipolar components on the estimates obtained in an accelerated manner using this technique
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Mughal, Safeer Kamil. "The dose and dose-rate effects of paternal irradiation on transgenerational instability in mice." Thesis, University of Leicester, 2013. http://hdl.handle.net/2381/27822.
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Of the non-targeted, delayed consequences of exposure to ionising radiation, genomic instability is a particular area of concern, especially with regard to its manifestation in the non-exposed offspring of irradiated parents. However, further analysis of these effects and their implications is mainly limited by our understanding of the underlying mechanisms and the lack of reliable data for humans. As of yet, transgenerational instability has only been consistently demonstrated in animal models using high, acute doses of ionising radiation (> 1 Sv). To investigate the effects of low-dose acute and low dose-rate (chronic) irradiation and whether or not they are capable of destabilizing the genomes of the unexposed offspring, we exposed male BALB/c mice to a range of γ-ray doses (10- 100 cGy) and dose-rates (chronic and acute), and mated them to unexposed BALB/c females 10 weeks post-irradiation. The mutation frequency at the Ms6-hm locus was established in DNA samples extracted from the sperm of directly exposed mice, as well as from the sperm and brains of their F1, using the single-molecule PCR technique. A linear dose-response was observed for direct exposure across the range of acute doses, with a doubling dose of 57 cGy. Furthermore, 100 cGy of acute γ-rays was shown to be more mutagenic than chronic exposure to the same accumulated dose. However, acute exposure to 10-25 cGy failed to manifest genomic instability in the derived offspring. This was also true of low dose-rate exposure to 100 cGy. Only acute paternal exposure to 50 and 100 cGy resulted in transgenerational instability, to a similar extent for both doses. Analogous results were found for both tissues. Taken together, this would imply the presence of a stress-like response where a threshold of acute dose determines the onset of transgenerational instability. Our results also suggest that children whose fathers are subject to most forms of human exposure to ionizing radiation would be safe from the effect.
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Nassef, Mohamed. "Monitoring de dose pour la radiothérapie du cancer de la prostate." Thesis, Rennes 1, 2016. http://www.theses.fr/2016REN1S033/document.
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Cette thèse porte sur la prise en compte des variations anatomiques, notamment les déformations d’organes à risque (rectum, vessie), pouvant survenir lors du traitement de radiothérapie conformationnelle par modulation d’intensité du cancer de la prostate. Ces variations peuvent entrainer d’importants écarts dosimétriques par rapport au plan de traitement initialement optimisé, et augmenter le risque de complications. Grâce à l’évolution des dispositifs d’imagerie et des méthodes de traitement d’images, des approches permettant de cumuler la dose au cours du traitement ont été récemment proposées mais restent mal évaluées et leur intégration dans un schéma de radiothérapie adaptative suscite de nombreuses questions. Ainsi, la première partie de ce travail a consisté à évaluer, à l’aide d’un fantôme numérique, une méthode de suivi de dose développée récemment au LTSI. Les résultats obtenus ont montré que les incertitudes dosimétriques liées à l’algorithme de cumul de dose sont limitées par rapport aux dérives dosimétriques observées chez les patients. La seconde partie de ce travail a consisté à proposer une stratégie de radiothérapie adaptative reposant sur le suivi de dose et à évaluer son bénéfice dosimétrique sur trois patients pour lesquels des dérives avaient été observées. Le principe de cette méthode est de détecter les dérives dosimétriques entre la dose planifiée et la dose réellement délivrée et, si besoin, de les compenser grâce à une ou plusieurs replanifications. Les résultats obtenus ont montré que cette approche permet une réduction de la dérive aux organes à risque, tout en augmentant la dose au volume cible en comparaison à un traitement standard par IGRT, avec un nombre limité de replanifications (une ou deux) permettant d’envisager une implémentation cliniqueThis thesis concerns the compensation of the anatomical variations, mainly the organs at risk (rectum, bladder) deformations, which occur during intensity modulated radiotherapy of the prostate cancer. These variations can lead to significant dose drift compared to the initially planned dose, increasing the risk of toxicity. Thanks to the evolution of imaging devices and of image processing methods, dose accumulation processes, allowing to estimate the cumulated dose during the treatment, have been recently proposed. Nevertheless those strategies suffer of a lack of evaluation and their integration into an adaptive radiotherapy raises many questions. Thus, in the first part of this work, a dose accumulation method recently developed at the LTSI was evaluated using a numerical phantom. The results obtained showed that the dosimetric uncertainties related to the cumulated dose process remain low compared to the dose drifts observed for patients. The second part of this work aimed to develop a dose guided adaptive radiotherapy process and to evaluate its dosimetrical benefit using three patients showing a dose drift. The principle of this method is to detect a potential drift between the planned and actually delivered doses and, if necessary, to compensate them thanks to one or more replanning(s). The results have shown that this approach has reduced the dose drift to the organs at risk, while increasing the dose to the prostate compared to standard IGRT treatment, with a limited number of replannings (one or two), enabling to consider a clinical implementation
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Maués, Nadine Helena Pelegrino Bastos. "Otimização de protocolos de abdômen-pelve em tomografia computadorizada multislice utilizando associações de avaliações subjetivas e objetivas." Botucatu, 2017. http://hdl.handle.net/11449/152050.
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Orientador: Diana Rodrigues de PinaResumo: A tomografia computadorizada (TC) é amplamente utilizada no diagnóstico e estadiamento de patologias da região de abdômen-pelve devido a sua alta sensibilidade e especificidade. A possibilidade de adquirir maior número de imagens em menor tempo e a maior disponibilidade de equipamentos levaram a um aumento significativo dos exames de TC e consequente aumento das doses efetivas globais fornecidas por esta modalidade. Desta forma, foram desenvolvidas ferramentas que buscam reduzir as doses de radiação dos exames sem perda da qualidade da imagem. Uma destas ferramentas é a modulação automática da corrente do tubo (automatic tube current modulation – ATCM), que permite a obtenção de exames que concordam com o princípio ALARA (as low as reasonably achievable). O objetivo deste estudo foi avaliar a qualidade da imagem e as doses de radiação de diferentes protocolos de TC de abdômen-pelve com a ferramenta ATCM. Foram avaliados cinco protocolos de TC de abdômen-pelve com a ferramenta ATCM em dois tomógrafos distintos, um 16-canais e um 64 canais. Foi utilizado um fantoma antropomórfico para avaliações dosimétricas e um fantoma analítico para avaliações objetivas de qualidade da imagem. Para a análise subjetiva da qualidade da imagem, foram utilizados 15 exames retrospectivos de pacientes submetidos a TC de abdômen-pelve. Estes exames foram avaliados por um radiologista com experiência na área de tomografia de abdômen. As três análises forneceram informações que possibilitaram a escol... (Resumo completo, clicar acesso eletrônico abaixo)
Mestre
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Wernet, Katherine. "Being Green: One and Done." Scholarship @ Claremont, 2011. http://scholarship.claremont.edu/cmc_theses/135.
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This study aims to understand the extent to which Prius owners are susceptible to single action bias, a phenomenon that occurs when one executes an initial, single action to solve a particular problem and then ceases to take further action. Here, participants were of two groups – Prius owners and non-Prius owners. It was hypothesized that Prius owners would, in fact, be less likely to perform smaller, easier green tasks (such as recycling) than those who did not own the hybrid – simply because they believed they have already done their part for the environment. Results failed to allow a rejection of null hypothesis. Further explored in the non-Prius group was recycling as the initial, single action, and a significant positive spillover effect was seen. Concern for the environment, regardless of car ownership, was a significant factor in green behavior. The Prius as a public statement of one‟s attitude is discussed.
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McMahon, S. J. "Heavy Atom Radiotherapy Dose Enhancement." Thesis, Queen's University Belfast, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.527871.
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Andersson, Karl Robert. "Dose-response-time data analysis." Thesis, University of Warwick, 2017. http://wrap.warwick.ac.uk/100470/.
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The traditional approach to pharmacodynamic modelling relies on knowledge about the pharmacokinetics. A prerequisite for obtaining kinetic information is reliable exposure data. However, in several therapeutic areas, exposure data are unavailable including when the drug response precedes the systemic exposure (for example pulmonary drug administration) and when the drug is locally administered (for example ophthalmics). Dose-response-time (DRT) data analysis provides an alternative to exposure-driven pharmacodynamic modelling when exposure data are sparse or lacking. In DRT modelling, the response data are assumed to contain enough information about the drug kinetics, whereby a biophase model can be developed and act as the driver of the pharmacological response. The following work presents the fundamental principles of DRT modelling. This include the entire procedure of identifying a DRT model, encompassing the assessment of the biophase function and the pharmacodynamic model, extensions to cover population variations, identifiability analysis, parameter estimation, and model validation. To demonstrate the utility of the technique, two extensive pre-clinical DRT studies of the interaction between nicotinic acid (NiAc) and free fatty acids (FFA) are presented. The first study covered the response behaviour following intravenous and oral NiAc dosing in both normal (lean) and diseased (obese) rats. The second study extended the models of the first study to incorporate insulin as a driver of the FFA response. Moreover, data from chronic trials were analysed with the aim to quantitatively understand the adaptive behaviours associated with long-term NiAc treatments. The aim of this work is to answer the questions of when and how to use DRT data analysis, and what the limitations of the method are. The DRT models of the first study were successfully fitted to all response-time courses in lean rats, with high precision in the parameter estimates (relative standard errors (RSE) < 25%), visual predictive check (VPC) and individual plots that captured the population and subject trends, and "-shrinkages of less than 10%. The model for the obese rats were less precise, with specific parameters being practically non-identifiable (with, for example, RSE 250%). The results for both lean and obese rats were generally consistent with those of an exposure-driven reference model, albeit with less precision and accuracy in the parameter estimates. Finally, the model was able to describe non-linear biophase kinetics, present at high oral dosages of NiAc. The DRT models of the second study were able to capture the response-time courses for insulin and FFA on a population and individual level, and for both lean and obese rats. However, many parameters were uncertain (with RSE of, for example, 30-50%) and some were practically non-identifiable (with RSE of > 100%). The estimates were generally less precise and more inaccurate than those obtained in an exposure-driven reference model. Yet, most parameter estimates of the DRT models were within one standard deviation from those of the exposure-driven model. The final model was used to predict steady-state FFA exposures following repeated NiAc dosing for a range of different infusion protocols. The optimal dosing regimens consisted of infusions and wash-out periods were the wash-outs were 2h longer than the infusions. These predictions were consistent with those made by the exposure-driven model. Albeit, the DRT model predicted a slightly lower optimal reduction of FFA exposure. It is important to recognise that DRT analyses introduce bias and variability in the parameter estimates. To obtain reliable results, it is advisable to have rich pharmacodynamic data, covering drug administration at different routes, rates, and schedules. With these issues taken into account, the technique still performed well in the two extensive studies presented in this work. In conclusion, DRT data analysis is a modelling technique used in situations when exposure data are unavailable. The method is versatile and can describe a range of different pharmacological behaviours. Precision and accuracy is lost when comparing to an exposure driven pharmacodynamic modelling approach. Thus, DRT modelling is not to be considered as a replacement of the gold-standard pharmacokinetic-pharmacodynamic framework, but rather as a compliment when exposure data are unavailable.
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Xiaoqing, Liu. "Dose-banding studies on oxaliplatin." Thesis, University of Plymouth, 2016. http://hdl.handle.net/10026.1/8081.
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Oxaliplatin is an anticancer drug widely used in cancer chemotherapy. This thesis evaluates whether a specific dose-banding scheme for oxaliplatin could replace the individual dosing method that is currently used in the oxaliplatin administration. Dose-banding was introduced into UK clinical practice in 2001, as it reduces delays in patients receiving their treatment and, through quality control and end-product testing, safeguards the infusion quality and patient safety. A range of studies were included in this thesis: an extended stability study on oxaliplatin infusions using a sequential temperature cycling design; studies on oxalate, a potential degradation product and metabolite of oxaliplatin which has been linked to oxaliplatin neurotoxicity and the development of an ex vivo pharmacokinetic (PK) simulation model to compare the effect of different oxaliplatin dosing methods on its therapeutic outcomes. The shelf-life of oxaliplatin infusions over a concentration range of 0.2 mg/mL – 0.7 mg/mL is extended to 84 days when stored at 2 – 8℃ plus a further 7 days after being left at room temperature (25℃) for 24 hours. This ensures the unused oxaliplatin infusions are safe to be re-issued to patients, which could reduce drug wastage. The oxalate study suggests that the dose-limiting neurotoxicity of oxaliplatin is unlikely to be directly related to the oxalate produced from oxaliplatin degradation in infusions or from the non-enzymic transformation of oxaliplatin in vivo because the oxalate levels from these routes are minor compared to the endogenous level. The safety and efficacy of dose-banding schemes was demonstrated by comparing the simulated PK characteristics gained from the ex vivo model. Dose-banding with the +10% maximum deviation was selected as the most promising dosing scheme for oxaliplatin. Finally, recommendations are made concerning the introduction of oxaliplatin dose-banding scheme into clinical practice, and on the benefits of harmonised dose-banding schemes.
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Barrientos, Tapia Laura Lucía, Salcedo Max Paul Bustamante, Sovero Ana Paola García, and Ñahui Doris Cecilia Jimenez. "Diva App : belleza donde estés." Bachelor's thesis, Pontificia Universidad Católica del Perú, 2016. http://tesis.pucp.edu.pe/repositorio/handle/123456789/9377.
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En un contexto en el que las personas cada vez disponen de menor tiempo libre es
necesario ofrecer soluciones que permitan el ahorro de tiempo. Por ello, el presente plan de
negocios tiene como objetivo presentar a Diva App, una empresa enfocada en atender la necesidad
de optimización de tiempo ofreciendo servicios de belleza a domicilio a mujeres que laboran.
A nivel internacional, existen negocios de belleza que han optado por ofrecer servicios
exclusivamente a domicilio y han innovado usando aplicaciones móviles para la reserva de citas.
En el Perú en cambio, aún hay un mercado por desarrollar debido a que sólo hay una empresa
nueva que aplica esta tecnología para atender a domicilio.
Tomando como base el modelo internacional, este plan de negocios plantea ofrecer sus
servicios través de una aplicación móvil. La propuesta de valor se basa principalmente en contar
con profesionales certificados que sean capacitados regularmente yel uso de insumos de calidad
debido a que estos atributos fueron los más valorados por el grupo objetivo. Asimismo, se
brindarán consejos en imagen personal durante el desarrollo de los servicios de belleza.
Para conocer el mercado se realizó una investigación bajo un enfoque mixto, empleando
herramientas de investigación cualitativas y cuantitativas. Inicialmente y de manera exploratoria,
se realizaron entrevistas a expertos en el sector, además de entrevistas y un focus group dirigido
al grupo objetivo potencial. Con ello se definió atender a mujeres que laboran entre 21 y 35 años,
que residan en los distritos de San Borja, Surco, Miraflores, San Isidro y La Molina.
Para validar la propuesta, se realizó una segunda ronda de entrevistas a profundidad a
expertos. Esto se complementó con encuestas que como resultado mostraron un alto grado de
aceptación de la propuesta planteada. Al ser atractivo por el grupo objetivo, se decide aprovechar
la oportunidad y desarrollar el negocio.
Para llevarlo a cabo, se estima una inversión de S/. 172,210 que será íntegramente
financiada por capital propio de los cuatro socios. La tasa interna de retorno (TIR) es de 37% y el
valor presente neto (VPN) asciende a S/. 503,146. Además, es posible cubrir los costos fijos
durante el primer año de operaciones. Finalmente, el periodo de retorno es de 4.82 años, por lo
que se puede considerar el proyecto como viable económicamente.Trabajo de suficiencia profesional
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Colucci, Elisabetta. "Dose in stroke rehabilitation trials." Thesis, University of East Anglia, 2016. https://ueaeprints.uea.ac.uk/62989/.
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Background: the dose and the length of rehabilitative interventions for optimal motor recovery after stroke are unknown. Dose optimization studies are required as precursors to efficacy trials, but are rarely conducted in stroke rehabilitation research. Objective: to overcome the knowledge gap on appropriate dose and length of rehabilitative interventions guiding the implementation of novel effective approaches to dose optimization in stroke rehabilitation research. Method: two systematic reviews on dose optimization in exercise-based training and pharmaceutical clinical research guided the development of a new approach to dose-finding suitable for physical interventions. The feasibility of a novel phase I 3+3 rule-based, outcome-adaptive dose-finding design was assessed with stroke survivors with moderate upper limb paresis. Moreover, the feasibility of a repetitive assessment procedure to identify the appropriate length of motor interventions was explored in stroke rehabilitation research. Results: the first literature review showed a lack of reliable approaches to dose optimization in exercise-based training. The review of pharmaceutical research highlighted dose optimization “gold” standard approaches, and helped in devising the dose-finding study for physical intervention. The dose-finding study was feasible using the applied model-task intervention. Preliminary explorations on the dose-response relationship were possible indicating a maximum tolerable dose and a potential recommended dose of 209 and 162 repetitions respectively of the applied intervention-task. The repetitive assessment procedure was found feasible in a clinical efficacy stroke rehabilitative trial. The repetitive assessment procedure provided relevant data on the therapy effect over-time showing that more than six weeks of the applied upper limb intervention may be necessary to reach maximal therapy effects. Whereas, five weeks of intervention appeared enough to exploit therapy effects for the lower limb. Conclusions: results are promising on identifying relevant dose and protocol endpoints implementing dose-finding and repetitive assessments approaches in stroke rehabilitation. Further confirmative data are needed to validate these findings.
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Fang, Qijun. "Hierarchical Bayesian Benchmark Dose Analysis." Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/316773.
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An important objective in statistical risk assessment is estimation of minimum exposure levels, called Benchmark Doses (BMDs) that induce a pre-specified Benchmark Response (BMR) in a target population. Established inferential approaches for BMD analysis typically involve one-sided, frequentist confidence limits, leading in practice to what are called Benchmark Dose Lower Limits (BMDLs). Appeal to hierarchical Bayesian modeling and credible limits for building BMDLs is far less developed, however. Indeed, for the few existing forms of Bayesian BMDs, informative prior information is seldom incorporated. Here, a new method is developed by using reparameterized quantal-response models that explicitly describe the BMD as a target parameter. This potentially improves the BMD/BMDL estimation by combining elicited prior belief with the observed data in the Bayesian hierarchy. Besides this, the large variety of candidate quantal-response models available for applying these methods, however, lead to questions of model adequacy and uncertainty. Facing this issue, the Bayesian estimation technique here is further enhanced by applying Bayesian model averaging to produce point estimates and (lower) credible bounds. Implementation is facilitated via a Monte Carlo-based adaptive Metropolis (AM) algorithm to approximate the posterior distribution. Performance of the method is evaluated via a simulation study. An example from carcinogenicity testing illustrates the calculations.
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Cherry, Shirley J. "Considering Patient and Radiographer Dose." Digital Commons @ East Tennessee State University, 2009. https://dc.etsu.edu/etsu-works/2482.
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Sasse, Ângela Deeke. "Doce flauta doce : um estudo de caso sobre o papel do espetáculo didático em atividades de apreciação musical direcionadas ao público infantil." reponame:Repositório Institucional da UFPR, 2016. http://hdl.handle.net/1884/45166.
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Orientadora: Prof. Dr. Guilherme Gabriel Ballande RomanelliDissertação (mestrado) - Universidade Federal do Parana, Setor de Artes, Comunicação e Design, Programa de Pós-Graduação em Música. Defesa: Curitiba, 21/03/2016
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Resumo: Esta pesquisa teve por objetivo explicitar o papel do espetáculo didático musical Doce Flauta Doce em atividades de apreciação musical do público infantil em ambiente escolar. Foi realizado um diagnóstico prévio do público infantil participante da pesquisa; analisou-se a influência desse espetáculo sobre o interesse das crianças em tocar um instrumento musical, bem como suas impressões e participações diante do espetáculo; e foram especuladas as possibilidades de aprendizagem musical decorrentes do espetáculo. No primeiro capítulo é apresentado o concerto didático como uma forma de ensino musical informal e exemplos de projetos estruturados envolvendo este tema. No capítulo seguinte apresentam-se reflexões de educadores musicais sobre a apreciação musical e sua função no ensino musical. A metodologia adotada foi estudo de caso, que incluiu duas apresentações do espetáculo didático musical Doce Flauta Doce, no ano de 2015, em uma escola pública do município de Curitiba. O instrumento de pesquisa adotado consiste em questionários com três categorias de público participantes desta experiência: as crianças, os professores e os músicos envolvidos, e, complementarmente, em desenhos elaborados pelas crianças após o espetáculo. Pôde-se concluir que as crianças, por meio do espetáculo, entraram em contato com a diversidade de instrumentos, puderam compará-los, analisá-los, e também conhecer como funcionam. Além disso, percebeu-se que quando solicitadas a participar da performance, o grau de engajamento e atenção aumenta consideravelmente. Com esta pesquisa constata-se que o espetáculo didático musical Doce Flauta Doce, por meio da apreciação musical ao vivo, propiciou a aproximação das crianças à música instrumental, com liberdade expressiva, despertando nelas a curiosidade pelo diferente (independente de seu gosto musical), e proporcionando autonomia para que pudessem realizar as suas próprias conexões entre o que viram e escutaram, e suas próprias experiências com a música. Palavras-chave: Flauta doce. Espetáculo didático musical. Apreciação musical. Ambiente escolar.
Abstract: This research aimed to explain the role of the didactic musical spectacle Doce Flauta Doce on music listening of children's audience in the school environment. First, it was made a previous diagnosis of the child audience participant of the research. Then, the influence of this spectacle on children's interest in playing a musical instrument was analyzed, as well as their impressions of the spectacle, and their participation in it. The possibilities of musical learning resulting from the spectacle were speculated. The first chapter presents the didactic concert as a form of informal music teaching and also some examples of structured projects involving this subject. The next chapter presents some reflections of music educators on music listening and their role in music teaching. The methodology used was case study, which included two performances of the didactic musical spectacle Doce Flauta Doce, in 2015, in a public school in the city of Curitiba. The research instrument adopted consisted of questionnaires applied to three categories of people that participated in this experience: children, teachers and musicians. Additionally, the research instrument consisted also of drawings produced by the children after the spectacle. It was possible to conclude that children, thanks to the spectacle, came into contact with the diversity of instruments, could compare them, analyze them, and also know how they work. Moreover, it was noticed that when asked to participate in the performance, the degree of engagement and attention has increased considerably. As a result of this research it appears that the didactic musical spectacle Doce Flauta Doce, through the live music listening, propitiated the approximation of children to the instrumental music, with expressive liberty, awakening in them the curiosity about the unknown (regardless of their musical tastes), and providing them autonomy to make their own connections between what they saw and listened and their own experience with music. Keywords: Recorder. Didactic musical spectacle. Music listening. School environment.
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Booth, Jeremy T. "Modelling the impact of treatment uncertainties in radiotherapy." Adelaide, S.A, 2002. http://web4.library.adelaide.edu.au/theses/09PH/09phb7255.pdf.
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Copies of the author's published articles derived from this thesis work are included in appendix. Bibliography: p. 223-237. This thesis involves three major streams of research including investigation of the actual dose delivered to target and normal tissue, the effect of dose uncertainty on radiobiological indices, and techniques to display the dose uncertainty in a treatment planning system. All of the analyses are performed with the dose distribution from a four-field box treatment using 6 MV photons.
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Egbe, Nneoyi Onen. "Measurement of dose in diagnostic radiology and the effect of dose reduction on image quality." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources. Online version available for University members only until March, 23, 2010, 2008. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=25469.
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Ball, Jessica Lynne. "Field and numerical investigations of lava dome hydrothermal systems and their effects on dome stability." Thesis, State University of New York at Buffalo, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3612916.
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This study investigates the potential for hydrothermal alteration and circulation in lava domes using combined analytical, remote sensing and numerical modeling approaches. This has been accomplished in three parts: 1) A comprehensive field, geochemical and remote sensing investigation was undertaken of the hydrothermal system in the Santiaguito lava dome complex in Guatemala. The Santiaguito domes were found to contain mainly hydrous silica alteration, which is unlikely to weaken dome rock, but the summit of Santa Maria was found to contain pervasive argillic alteration (clay minerals), which do pose more of a collapse-related hazard. These results were confirmed by hot spring geochemistry which indicated that water in the domes was responsible for some rock dissolution but had a residence time too short to allow for secondary mineralization. 2) A finite element numerical modeling approach was developed which was designed to simulate the percolation of meteoric water in two dome geometries (crater-confined and 'perched'), and the results were compared to the surface expression of hydrothermal systems on existing lava domes. In both cases, we concluded that simulated domes which lacked a high-temperature (magmatic) heat source could not develop a convecting hydrothermal system and were dominated by gravitational water flow. In these low-temperature simulations, warm springs (warmer high fluid fluxes) were produced at the base of the dome talus and cool springs were dispersed lower down the slope/substrate; fumaroles (high vapor fluxes) were confined to the dome summits. Comparison with existing dome cross sections indicates that the simulations were accurate in predicting fumarole locations and somewhat accurate at predicting spring locations, suggesting that springs may be subject to permeability contrasts created by more complicated structural features than were simulated in this study. 3) The results of the numerical modeling were used to calculate alteration potential in the simulated domes, indicating the most likely areas where alteration processes might either reduce the strength of a dome or reduce permeability that could contribute to internal pressurization. Rock alteration potential in low-temperature lava domes was found to be controlled by material permeability and the presence or absence of a sustained heat source driving hydrothermal circulation. High RAI values were preserved longer in low-permeability domes, but were more strongly developed in domes with higher permeabilities. Potential for mineral dissolution was highest at the base of the dome core, while the potential for mineral precipitation is highest at the dome core-talus interface. If precipitated minerals are impermeable, the dome core/talus interface would be a likely location for accumulation of gases and initiation of gas-pressurization-related collapse; if alteration is depositing weak (i.e. clay) minerals in this area, the dome core/talus interface might be a candidate for collapses occurring as the result of alteration processes.
The results of this study are all geared toward answering two broad questions: Where are hydrothermal alteration processes likely to occur or be focused within lava domes? and What effect could these processes have on dome stability? In the specific case of the Santiaguito dome complex, the combination of a quickly-recharged, low-temperature hydrothermal system in the inactive domes actually indicated a low possibility of collapse related to alteration minerals. This result was reinforced by the results of the numerical modeling, which indicated that domes are unlikely to develop sustained hydrothermal convection without the presence of a significant (magmatic) heat source and—in the case of Santiaguito—are likely to produce more hydrous silica alteration minerals when they also lack a source of acidic gases. Models of alteration potential do detail, however, that both shallow and deep dome collapses are still a possibility with a low-temperature hydrothermal system, given either a) a source of acidic gases to drive the formation of clay minerals (which are most likely to be deposited at the core/talus interface of a dome, or b) enough deposition of silica minerals in pore spaces to lower permeability in dome rock and promote internal gas pressurization. The results of this study are not limited to lava domes, as the volcanic edifices on which they rest are composed of the same materials that comprise lava domes and are therefore susceptible to the same hydrothermal processes. Further simulations of both lava domes and their associated edifices, including mineral species models, could help constrain under what conditions a lava dome or volcano is likely to develop areas of weak mineral precipitates (such as clay minerals) which could provide sites for collapse, or develop an impermeable cap of silicate minerals which could trap rising vapor and contribute to the pressurization of the edifice in question (which can in turn lead to collapse).
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Tempass, Mártin César. ""Quanto mais doce, melhor" : um estudo antropológico das práticas alimentares da doce sociedade Mbyá-Guarani." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2010. http://hdl.handle.net/10183/24852.
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A presente tese de Doutorado em Antropologia Social parte da constatação de que o sabor doce é muito importante para os seres humanos. Aliás, ao contrário do que afirma a bibliografia, a produção e o consumo de doces são muito difundidos inclusive entre os grupos indígenas. Desta forma, tem-se como objetivo uma análise antropológica da produção e consumo de alimentos entre os Mbyá-Guarani – grupo indígena brasileiro – enfatizando os seus sabores doces e os sentidos a eles atribuídos. A partir dos dados obtidos junto aos Mbyá-Guarani é possível repensar a contribuição dos grupos indígenas na formação da culinária e, mais especificamente, o papel destes grupos na cultura doceira brasileira.This thesis of Doctorate in Social Anthropology starts from the fact that the sweet flavor is very important to human being. Moreover, contrary to what the literature says, the production and consumption of sweets is very widespread even among indigenous group. Thus, it has at objective an anthropological analysis of food’s productions and consumption among the Mbyá-Guarani – Brazilian indigenous group - emphasizing the sweet flavor and the meaning give to them. From the data obtained from the Mbyá-Guarani is possible rethink the contribution of indigenous group in the formation of the cuisine and, more specifically, the role of this group in the Brazilian culture of make sweets.
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MEIER, BRIAN ARTHUR. "DOSE-RESPONSE OF LOW DOSE CO-EXPOSURES TO ARSENIC AND BENZO[a]PYRENE IN MICE." University of Cincinnati / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1085496296.
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Ashton, Christopher D. "Total dose radiation test methodologies for advanced spacecraft electronics experiencing enhanced low dose rate sensitivity." Thesis, University of Surrey, 2016. http://epubs.surrey.ac.uk/810105/.
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The purpose of this thesis is to determine whether hydrogen can be implanted into elec- tronic components for the goal of investigating low ionising dose rate sensitivity, and using this to suggest whether hydrogen implantation can be used as an accelerated method to detect ELDRS (Enhanced Low Dose Rate Sensitivity) susceptability. Current ground testing methods for total ionising dose irradiate using cobalt-60 at dose rates greater than 10mGy(Si)/s up to 200Gy. It has been found that bipolar devices show an increased susceptibility to radiation induced damage at dose rates below 10mGy(Si)/s known as ELDRS. Current research has linked ELDRS susceptibility with hydrogen content within the integrated circuit and experiments based upon hydrogen soaking de-lidded bipolar devices demonstrate this relationship, however this has not led to an accepted method for testing ELDRS susceptibility in previously un-tested devices. In this thesis, a novel proposal is put forward whereby bipolar devices are directly implanted with hydrogen using a targeted ion beam in order to accelerate the testing process. Hydrogen implantation via a 600keV ion beam has been achieved to a level of 10^17 H/cm^2 in Analog Device’s AD590KF temperature transducer, and 10^14-15 H/cm^2in National Semiconductor’s LM124 quad operational amplifiers. Devices were decapped, optically analysed, and targeted with a focussed proton beam. These devices were then irradiated at 15mGy/s, 5mGy/s and 15mGy/s. Increased degradation was seen at lower dose rates which was matched by high dose rate irradiation of the implanted devices followed by a room temperature anneal. The use of ion implantation for the development of an accelerated ELDRS test method is proposed. This thesis demonstrated that hydrogen can be succesfully implanted into devices, established an upper bound for the LM124 for implantation and a lower bound for hydrogen remaining in the target area and the effect of hydrogen implantation on the AD590 temperature transducer is discussed. This thesis concludes by suggesting hydrogen implantation as a method for use by manufacturers during the design and investigation of intrinsically ELDRS-free technologies.
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Younan, Fouad. "Reconstruction de la dose absorbée in vivo en 3D pour les traitements RCMI et arcthérapie à l'aide des images EPID de transit." Thesis, Toulouse 3, 2018. http://www.theses.fr/2018TOU30333/document.
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Cette thèse a été réalisée dans le cadre de la dosimétrie des faisceaux de haute énergie délivrés au patient pendant un traitement de radiothérapie externe. L'objectif de ce travail est de vérifier que la distribution de dose 3D absorbée dans le patient est conforme au calcul réalisé sur le système de planification de traitement (TPS) à partir de l'imageur portal (en anglais : Electronic Portal Imaging Device, EPID). L'acquisition est réalisée en mode continu avec le détecteur aS-1200 au silicium amorphe embarqué sur la machine TrueBeam STx (VARIAN Medical system, Palo Alto, USA). Les faisceaux ont une énergie de 10 MeV et un débit de 600 UM.min-1. La distance source-détecteur (DSD) est de 150 cm. Après correction des pixels défectueux, une étape d'étalonnage permet de convertir leur signal en dose absorbée dans l'eau via une fonction de réponse. Des kernels de correction sont également utilisés pour prendre en compte la différence de matériaux entre l'EPID et l'eau et pour corriger la pénombre sur les profils de dose. Un premier modèle de calcul a permis ensuite de rétroprojeter la dose portale en milieu homogène en prenant en compte plusieurs phénomènes : les photons diffusés provenant du fantôme et rajoutant un excès de signal sur les images, l'atténuation des faisceaux, la diffusion dans le fantôme, l'effet de build-up et l'effet de durcissement du faisceau avec la profondeur. La dose reconstruite est comparée à celle calculée par le TPS avec une analyse gamma globale (3% du maximum de dose et 3 mm de DTA). L'algorithme a été testé sur un fantôme cylindrique homogène et sur un fantôme de pelvis à partir de champs modulés en intensité (RCMI) et à partir de champs d'arcthérapie volumique modulés, VMAT selon l'acronyme anglais Volumetric Modulated Arc Therapy. Le modèle a ensuite été affiné pour prendre en compte les hétérogénéités traversées dans le milieu au moyen des distances équivalentes eau dans une nouvelle approche de dosimétrie plus connue sous le terme de " in aqua vivo " (1). Il a été testé sur un fantôme thorax et, in vivo sur 10 patients traités pour une tumeur de la prostate à partir de champs VMAT. Pour finir, le modèle in aqua a été testé sur le fantôme thorax avant et après y avoir appliqué certaines modifications afin d'évaluer la possibilité de détection de sources d'erreurs pouvant influencer la bonne délivrance de la dose au patient.[...]This thesis aims at the dosimetry of high energy photon beams delivered to the patient during an external radiation therapy treatment. The objective of this work is to use EPID the Electronic Portal Imaging Device (EPID) in order to verify that the 3D absorbed dose distribution in the patient is consistent with the calculation performed on the Treatment Planning System (TPS). The acquisition is carried out in continuous mode with the aS-1200 amorphous silicon detector embedded on the TrueBeam STx machine (VARIAN Medical system, Palo Alto, USA) for 10MV photons with a 600 UM.min-1 dose rate. The source-detector distance (SDD) is 150 cm. After correction of the defective pixels, a calibration step is performed to convert the signal into an absorbed dose in water via a response function. Correction kernels are also used to take into account the difference in materials between EPID and water and to correct penumbra. A first model of backprojection was performed to reconstruct the absorbed dose distribution in a homogeneous medium by taking into account several phenomena: the scattered photons coming from the phantom to the EPID, the attenuation of the beams, the diffusion into the phantom, the build-up, and the effect of beam hardening with depth. The reconstructed dose is compared to the one calculated by the TPS with global gamma analysis (3% as the maximum dose difference criteria and 3mm as the distance to agreement criteria). The algorithm was tested on a homogeneous cylindrical phantom and a pelvis phantom for Intensity-Modulated Radiation Therapy (IMRT) and (Volumetric Arc Therapy (VMAT) technics. The model was then refined to take into account the heterogeneities in the medium by using radiological distances in a new dosimetrical approach better known as "in aqua vivo" (1). It has been tested on a thorax phantom and, in vivo on 10 patients treated for a prostate tumor from VMAT fields. Finally, the in aqua model was tested on the thorax phantom before and after making some modifications to evaluate the possibility of detecting errors that could affect the correct delivery of the dose to the patient. [...]
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Pinho, Regina Smith [UNESP]. "Comparação entre ágar e amido como agentes gelificantes na micropropagação de batata doce Ipomoea batatas (L.) Lam." Universidade Estadual Paulista (UNESP), 2002. http://hdl.handle.net/11449/93574.
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pinho_rs_me_botfca.pdf: 249630 bytes, checksum: 76288475927496cf6d3167ab94a6567c (MD5)O presente trabalho foi realizado no Departamento de Química e Bioquímica, do Instituto de Biociências, da Universidade Estadual Paulista, Campus de Botucatu. Teve como objetivo avaliar o desenvolvimento da batata doce (Ipomoea batatas L.) em meio de cultura modificado por amido e verificar a possibilidade de substituição do agente gelificante ágar por amido durante a micropropagação. O experimento foi dividido em duas fases: estabelecimento e multiplicação. Na fase de estabelecimento foram testadas três metodologias de assepsias para desinfestação das microestacas (Assepsia 1 - 40% de solução de hipoclorito de sódio com 2,5% de Cloro ativo, por 20 minutos, Assepsia 2 - 50% de solução de hipoclorito de sódio com 2,5% de Cloro ativo, por 20 minutos seguido de solução de álcool 70% por 1 minuto, Assepsia 3 - 50% de solução de hipoclorito de sódio com 2,5% de Cloro ativo por 20 minutos). Na fase de multiplicação foram testados 4 tipos de meio de cultura (T1- 0,6% ágar e sacarose P.A 30 g.L-1, T2- 7% da mistura de amido e sacarose P.A 30 g.L-1, T3- 0,6% ágar e açúcar cristal comercial 30 g.L-1, T4- 7% da mistura de amido e açúcar cristal comercial 30 g.L-1). Na primeira fase foi realizada uma avaliação aos 30 dias de desenvolvimento, determinando-se o número de microestacas contaminadas por fungos e bactérias, total de microestacas com desenvolvimento de parte aérea e raiz e o número de gemas desenvolvidas. Na segunda fase foram realizadas 4 coletas (aos 0 dias, 10 dias, 20 dias e 30) dias onde analisou-se as condições dos meios de cultura (pH, condutividade elétrica e açúcares redutores) e o desenvolvimento das microestacas (massa de matéria fresca e proteínas solúveis)... .
The present work was undertaken at the Department of Chemistry and Biochemistry of the Instituto de Biociências, at the Universidade Estadual Paulista, Botucatu Campus. The objective was to evaluate the development of the sweet potato (Ipomoea batatas L.) in a starch-modified culture and verify the possibility of the substitution of the agar agent for starch in the micro propagation of the sweet potato. The experiment was divided in two phases: establishment and multiplication. During the establishment phase three kinds of asepsis for the disinfection of the micro stakes (Asepsis 1 - 40% of solution of sodium hip chlorite with 2,5% of active Chlorine for 20 minutes, Asepsis 2 - 50% of solution of sodium hip chlorite with 2,5% active Chlorine for 20 minutes followed by an alcohol solution at 70% for 1 minute, Asepsis 3 - 50% of solution of sodium hip chlorite with 2,5% active Chlorine), in the multiplication phase 4 types of medium culture were tested (T1- 0,6% agar and saccharin P.A 30 g.L-1, T2- 7% of the starch-saccharin mix P.A 30 g.L-1, T3- 0,6% agar and commercial crystal sugar 30 g.L-1, T4- 7% of the starch-saccharin mix P.A 30 g.L-1). During the first phase an assessment was carried out on the 30th day of development , to determine the number of micro stakes contaminated with fungi and bacteria , the total of micro stakes with aerial part and root development and the number of developed geμS. During the second phase samples were collected on the day 0, day 10, day 20 and day 30 when the culture medium were analyzed (pH, electric conductibility, and reducing sugars) and the development of micro stakes (fresh matter mass and soluble proteins). The Asepsis 2 (50% of solution of sodium hip chlorite with 2,5% active Chlorine for 20 minutes followed by alcohol solution at 70% for 1 minute) was the one to achieve better results and the use of... (Complete abstract, click electronic address below).
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Leite, Marina Silveira. "Kerma no ar com base no índice de exposição para radiografia digital." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/59/59135/tde-22072013-104719/.
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Os receptores de imagem radiográfica digitais estão gradualmente substituindo os sistemas tela-filme em radiodiagnóstico. Atualmente a radiografia computadori- zada (CR - Computed Radiography) é a modalidade digital mais comum em muitos serviços de radiodiagnostico. E baseada na utilização de fósforos foto estimuláveis, que também são conhecidos como fósforo de armazenamento. Quando sistemas tela-filme são utilizados como receptores de imagem, uma dose de radiação inadvertidamente alta no paciente irá resultar em um filme escuro, que fornece feedback imediato para o técnico em radiologia quanto aos fatores de técnica utilizados e a dose relativa. No entanto, quando receptores de imagem digitais são usados, uma dose alta no paciente pode produzir imagens excelentes o que resulta em uma tendência de se utilizar doses mais elevadas do que o necessário. A adequada justificação e otimização dos procedimentos exige o conhecimento dos valores típicos de dose em pacientes em um determinado serviço de radiodiagnóstico. O termo índice de exposição refere-se à dose absorvida na placa fósforo. Após a leitura da imagem com um sistema de laser o histograma dos sinais é computado e o índice de exposição é determinado com base nos valores dos pixels (picture elements) usando uma relação logarítmica. Os fabricantes dos sistemas de CR oferecem os índices de exposição como um salvaguarda contra doses altas, mas a base para os valores recomendados não é clara. Além disso, os índices de exposição não estão diretamente relacionados com a dose no paciente. O objetivo deste trabalho foi estabelecer um método indireto para calcular os valores de dose de entrada em pacientes submetidos a exames diagnósticos em sistemas de raios X com CR com base no índice de exposição.The receptors of digital radiography image are gradually substituting the screen-film systems in radiodiagnostic. Currently, computed radiography is the most common method in many radiography services. It is based in the application of photostimulable phosphorus, that are also known as phosphorus storage. When screen-film systems are utilized as image receptors, an inadvertently high dose of radiation in the patient will result in a dark film screen, that inputs immediate feedback to the radiology technician as to the technical factors utilized and the relative dose. However, when digital image receptors are used, a high dose in the patient can produce excelent images which re-sult in a tendency of using higher doses than necessary. The adequate extenuation and optimization of the procedures demand the knowledge of the characteristic dose values in patients in a determined radiodiagnostic service. The term exposure index refers to the absorbed dose in the phosphorus plate. Following the image reading with a laser system the histogram of signs is computed and the exposure index is determi-ned in the basis of picture elements using a logarithmic relationship. The manufacturer of the systems of pixels offer the exposure indexes as a safeguard against high doses, but the basis for the recommended values are not clear. Moreover, the exposure indexes are not directly related to the dose in patients. The aim of this work was to establish an indirect method to estimate the values of entrance doses in patients who have undergone diagnostic exams in X ray systems with computed radiography based on exposure indexes. The values of entrance doses obtained were compared with the values also obtained indirectly based in the measurements of the X ray tubes output.
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Silva, Amanda Juliene da. "Avaliação da dose ocupacional oriunda dos procedimentos especiais guiados por fluoroscopia: cateterismo cardíaco." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-02032012-134504/.
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A principal finalidade deste estudo foi avaliar a dose efetiva recebida pelos profissionais de saúde no setor de hemodinâmica de um hospital universitário, na cidade de São Paulo. Para delinear o perfil dos profissionais de saúde foi utilizado um questionário auto-aplicável considerando as variáveis sociodemográficas e variáveis relacionadas ao trabalho em presença de radiação ionizante. A avaliação das doses ocupacionais foi realizada por meio de consulta aos históricos de dose individual do banco de dados da instituição, durante os anos de 2000 a 2009. Um total de 240 registros foi avaliado, envolvendo 38 profissionais ativos (2009), de diferentes categorias profissionais, entre elas, médicos, enfermeiros, tecnólogos em radiologia e auxiliares de enfermagem. As doses efetivas anuais foram comparadas com os limites estabelecidos pelas autoridades regulatórias nacionais. Com base nas doses recebidas e registradas durante o período estudado, foram selecionados cinco médicos para usar mais um dosímetro termoluminescente (em caráter experimental) na mão esquerda, durante a realização dos procedimentos de hemodinâmica. Além disso, foram averiguados os procedimentos de radioproteção adotados pelos profissionais de saúde da instituição estudada. Este estudo permitiu traçar o perfil da equipe médica que integra o serviço de hemodinâmica assim como conhecer a distribuição de suas doses em relação aos limites ao longo dos anos.The purpose of this study was to evaluate the dose received by health professionals in the hemodynamic sector of a university hospital in São Paulo city. A self-applied questionnaire was used to delineate the profile of health professionals, taking into account sociodemographic variables and variables related to the work with ionizing radiation. The assessment of occupational doses was performed by consulting of the individual dose records of the institution database from 2000 to 2009. A total of 240 records was evaluated, corresponding to 38 active professionals (2009), divided in different professional category: physician, nurses, radiologic technologists and nursing assistants. The annual doses were compared with the limits established by national regulatory authorities. Based on the effective doses received and recorded during the studied period, experimental measures were performed with TL dosimeters in five physicians to evaluate the equivalent dose, in the left hand, during hemodynamic procedures. In addition, the radioprotection measures adopted by health professionals were verified. This study allowed delineating the profile of medical staff that integrates the hemodynamic service as well as knowing the distribution of their doses in relation to limits over the years.
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Pinho, Regina Smith 1972. "Comparação entre ágar e amido como agentes gelificantes na micropropagação de batata doce Ipomoea batatas (L.) Lam. /." Botucatu : [s.n.], 2002. http://hdl.handle.net/11449/93574.
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Orientador: Giuseppina Pace Pereira LimaResumo: O presente trabalho foi realizado no Departamento de Química e Bioquímica, do Instituto de Biociências, da Universidade Estadual Paulista, Campus de Botucatu. Teve como objetivo avaliar o desenvolvimento da batata doce (Ipomoea batatas L.) em meio de cultura modificado por amido e verificar a possibilidade de substituição do agente gelificante ágar por amido durante a micropropagação. O experimento foi dividido em duas fases: estabelecimento e multiplicação. Na fase de estabelecimento foram testadas três metodologias de assepsias para desinfestação das microestacas (Assepsia 1 - 40% de solução de hipoclorito de sódio com 2,5% de Cloro ativo, por 20 minutos, Assepsia 2 - 50% de solução de hipoclorito de sódio com 2,5% de Cloro ativo, por 20 minutos seguido de solução de álcool 70% por 1 minuto, Assepsia 3 - 50% de solução de hipoclorito de sódio com 2,5% de Cloro ativo por 20 minutos). Na fase de multiplicação foram testados 4 tipos de meio de cultura (T1- 0,6% ágar e sacarose P.A 30 g.L-1, T2- 7% da mistura de amido e sacarose P.A 30 g.L-1, T3- 0,6% ágar e açúcar cristal comercial 30 g.L-1, T4- 7% da mistura de amido e açúcar cristal comercial 30 g.L-1). Na primeira fase foi realizada uma avaliação aos 30 dias de desenvolvimento, determinando-se o número de microestacas contaminadas por fungos e bactérias, total de microestacas com desenvolvimento de parte aérea e raiz e o número de gemas desenvolvidas. Na segunda fase foram realizadas 4 coletas (aos 0 dias, 10 dias, 20 dias e 30) dias onde analisou-se as condições dos meios de cultura (pH, condutividade elétrica e açúcares redutores) e o desenvolvimento das microestacas (massa de matéria fresca e proteínas solúveis)... (Resumo completo, clicar acesso eletrônico abaixo).
Abstract: The present work was undertaken at the Department of Chemistry and Biochemistry of the Instituto de Biociências, at the Universidade Estadual Paulista, Botucatu Campus. The objective was to evaluate the development of the sweet potato (Ipomoea batatas L.) in a starch-modified culture and verify the possibility of the substitution of the agar agent for starch in the micro propagation of the sweet potato. The experiment was divided in two phases: establishment and multiplication. During the establishment phase three kinds of asepsis for the disinfection of the micro stakes (Asepsis 1 - 40% of solution of sodium hip chlorite with 2,5% of active Chlorine for 20 minutes, Asepsis 2 - 50% of solution of sodium hip chlorite with 2,5% active Chlorine for 20 minutes followed by an alcohol solution at 70% for 1 minute, Asepsis 3 - 50% of solution of sodium hip chlorite with 2,5% active Chlorine), in the multiplication phase 4 types of medium culture were tested (T1- 0,6% agar and saccharin P.A 30 g.L-1, T2- 7% of the starch-saccharin mix P.A 30 g.L-1, T3- 0,6% agar and commercial crystal sugar 30 g.L-1, T4- 7% of the starch-saccharin mix P.A 30 g.L-1). During the first phase an assessment was carried out on the 30th day of development , to determine the number of micro stakes contaminated with fungi and bacteria , the total of micro stakes with aerial part and root development and the number of developed geμS. During the second phase samples were collected on the day 0, day 10, day 20 and day 30 when the culture medium were analyzed (pH, electric conductibility, and reducing sugars) and the development of micro stakes (fresh matter mass and soluble proteins). The Asepsis 2 (50% of solution of sodium hip chlorite with 2,5% active Chlorine for 20 minutes followed by alcohol solution at 70% for 1 minute) was the one to achieve better results and the use of... (Complete abstract, click electronic address below).
Mestre
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LOPES, Cintya Carolina Barbosa. "Avaliação de dose em procedimentos especiais de fluoroscopia : histerossalpingografia e dacriocistografia." Universidade Federal de Pernambuco, 2006. https://repositorio.ufpe.br/handle/123456789/9940.
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Previous issue date: 2006Dentre os procedimentos especiais de fluoroscopia destacam-se a histerossalpingografia (HSG) e a dacriocistografia (DCG). A HSG é uma técnica radiodiagnostica capaz de detectar patologias uterinas e tubárias, e é fundamental para a investigação de infertilidade. A DCG trata-se do exame radiográfico do sistema lacrimal, sendo importante para mostrar o nível de obstrução, a presença de dilatação do saco lacrimal, bem como alterações em estruturas vizinhas. Neste trabalho, foi efetuado o estudo da dose de entrada na pele do paciente devido a estes dois procedimentos especiais de fluoroscopia, bem como a avaliação da dose na equipe médica que executa os exames. Para tanto, foram avaliados os procedimentos de 22 pacientes de HSG e 8 pacientes de DCG. Dosímetros de TLD-100 foram utilizados e fixados na pele dos pacientes em pontos anatômicos envolvidos em cada exame. No caso da HSG os resultados mostraram que a dose na entrada da pele variou de 0,5 mGy a 73,4 mGy, com um valor médio de 22,1 mGy. A dose no útero foi estimada em 5,5 mGy, e 6,6 mGy foi a dose média estimada para os ovários. As doses de entrada na pele dos pacientes submetidos a exames de DCG variaram de 2,1 mGy a 10,6 mGy, e a dose média entre os olhos foi de 6,1 mGy. Os resultados das doses ocupacionais mostraram que, na HSG, a dose média na mão direita do médico é de 4,3 mGy por exame. Este valor é devido ao fato que o médico introduz o meio de contraste manualmente durante as exposições com contraste na histerossalpingografia. Em relação a DCG, os valores de doses ocupacionais foram da ordem dos valores ambientais, evidenciando que, dentro dos limites permitidos, não há risco para os médicos neste procedimento
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Erekson, David McConkie. "Scheduled Healing: The Relationship Between Session Frequency and Psychotherapy Outcome in a Naturalistic Setting." BYU ScholarsArchive, 2013. https://scholarsarchive.byu.edu/etd/4037.
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The dose-effect relationship in psychotherapy has been examined extensively, but few studies have included session frequency as a component of psychotherapy "dose." Those studies that have examined the effects of session frequency have indicated that it may affect both the total amount of recovery and the speed of recovery. No studies were found examining the clinical significance of this construct in a naturalistic setting. The change trajectories of 16,003 clients were examined using multi-level modeling and including session frequency as a fixed effect. Of these clients, subgroups were identified that were scheduled approximately once a week or approximately once every two weeks. These groups were compared to each other for differences in speed of recovery and clinically significant change. Results indicated that more frequent therapy was associated with steeper recovery curves. When comparing groups scheduled once a week to those scheduled once every two weeks, more clinically significant gains were identified in those attending once a week, and more significant deterioration was identified in those attending once every two weeks. These findings are discussed in light of the existing literature and the implications for future psychotherapy research and clinical practice.