Dissertations / Theses on the topic 'DNA triplex'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 dissertations / theses for your research on the topic 'DNA triplex.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.
Sayoh, Ibrahim. "Factors affecting DNA Triplex formation." Thesis, University of Southampton, 2016. https://eprints.soton.ac.uk/403876/.
Full textAshley, Carolyn. "The role of triplex DNA in the cell." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0018/NQ43508.pdf.
Full textDosanjh, Harvinder Singh. "Biophysical studies of triplex and quadruplex DNA systems." Thesis, Institute of Cancer Research (University Of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409306.
Full textMayer, Alain. "Synthesis and triplex forming properties of pyrrolidino-DNA /." [S.l.] : [s.n.], 2005. http://www.zb.unibe.ch/download/eldiss/05mayer_a.pdf.
Full textRichards, Sally. "Inhibition of oncogene expression by the formation of Triplex DNA." Thesis, Institute of Cancer Research (University Of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368703.
Full textVadhia, Sunil Jayantilal. "The effect of modified nucleosides on DNA duplex and triplex stability." Thesis, University of Southampton, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.484953.
Full textVeach, Darren R. "SYNTHESIS AND EVALUATION OF 2,2-DIARYL-2,3-DIHYDROPHENANTHRO-[9,10-b]-1,4-DIOXIN PHOTONUCLEASES." University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin991653071.
Full textRead, Martin. "Molecular modelling and crystallographic studies of quadruplex and triplex DNA drug complexes." Thesis, Institute of Cancer Research (University Of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325536.
Full textKeppler, Melanie Dawn. "Strategies for increasing the stability of triple helical DNA." Thesis, University of Southampton, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302353.
Full textWeiser, Michal. "Akcelerace algoritmů pro hledání triplexů v DNA sekvencích." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2012. http://www.nusl.cz/ntk/nusl-236435.
Full textNam, Kang Hoon. "DNA complexes with adjacent duplex and triplex domains : thermal denaturation and gel mobility shift analysis." Diss., Georgia Institute of Technology, 1997. http://hdl.handle.net/1853/25196.
Full textZeng, Yingying. "Discrete Assembly of Synthetic Peptide-DNA Triplex Structures from Polyvalent Melamine-Thymine Bifacial Recognition." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1373981452.
Full textEvans, Kathryn. "An NMR study of a natural and a 3'-S-phosphorothiolate modified DNA triplex." Thesis, University of Leeds, 2012. http://etheses.whiterose.ac.uk/4143/.
Full textLombe, Chipampe Patricia. "Analysis, expression profiling and characterization of hsa-miR-5698 target genes as putative dynamic network biomarkers for prostate cancer: a combined in silico and molecular approach." University of the Western Cape, 2019. http://hdl.handle.net/11394/7026.
Full text2018, the International Agency for Research on Cancer (IARC) estimated that prostate cancer (PCa) was the second leading cause of death in males worldwide. The number of deaths are expected to raise by 50 % in the next decade. This rise is attributed to the shortcomings of the current diagnostic, prognostic, and therapeutic biomarkers used in the management of the disease. Therefore, research into more sensitive, specific and effective biomarkers is a requirement. The use of biomarkers in PCa diagnosis and management takes advantage of the genetic alterations and abnormalities that characterise the disease. In this regard, a microRNA, hsa-miR-5698 was identified in a previous study as a differentiating biomarker between prostate adenocarcinoma and bone metastasis. Six putative translational targets (CDKN1A, CTNND1, FOXC1, LRP8, ELK1 and BIRC2) of this microRNA were discovered using in silico approaches. The aim of this study was to analyse via expression profiling and characterization, the target genes of hsa-miR-5698 in order to determine their ability to act as putative dynamic network biomarkers for PCa. The study was conducted using a combined in silico and molecular approach. The in silico part of the study investigated the putative transcriptional effects of hsa-miR-5698 on the promotors of its translational targets, the correlation between hsa-miR-5698 and mRNA expression profiles as well as the co-expression analysis, pathway analysis and prognostic ability of the target genes. A number of computational software were employed for these purposes, including, R Studio, Trident algorithm, STRING, KEGG, MEME Suite, SurvExpress and ProGgene. The molecular part of the study involved expression profiling of the genes in two PCa cell line LNCaP and PC3 via qPCR.
Riechert-Krause, Fanny [Verfasser]. "Spectroscopic Studies on the Sequence-Selective Interactions of Bioactive Indoloquinolines with Duplex and Triplex DNA / Fanny Riechert-Krause." Greifswald : Universitätsbibliothek Greifswald, 2012. http://d-nb.info/1021841285/34.
Full textAlvira, Torre Margarita. "Modified oligonucleotides for triple helix studies and for the obtention of structures with biomedical and technological interest." Doctoral thesis, Universitat de Barcelona, 2010. http://hdl.handle.net/10803/80851.
Full textShrestha, Prakash. "FOLDING DYNAMICS OF G-QUADRUPLEXES DURING TRANSCRIPTION AND IN A NANO-CONFINEMENT." Kent State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=kent1514906810383603.
Full textKoirala, Deepak P. "Mechanochemistry, Transition Dynamics and Ligand-Induced Stabilization of Human Telomeric G-Quadruplexes at Single-Molecule Level." Kent State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=kent1397919270.
Full textZrůna, Michal. "Vyhledávání triplexů v DNA sekvencích." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2012. http://www.nusl.cz/ntk/nusl-236546.
Full textCassidy, Sarah Anne. "Stabilisation of DNA triple helices." Thesis, University of Southampton, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242535.
Full textRusling, David Anthony. "DNA recognition by triple helex formation." Thesis, University of Southampton, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494720.
Full textWashbrook, Elinor. "Alternate strand DNA triple helix formation." Thesis, University of Southampton, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242223.
Full textPaes, Hazel Margaret. "The kinetics of DNA triple helices." Thesis, University of Southampton, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242691.
Full textChandler, Simon Paul. "DNA sequence recognition by triple helix formation." Thesis, University of Southampton, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296164.
Full textMakube, Neo. "The triple-helical DNA four-way junction." Doctoral thesis, University of Cape Town, 1999. http://hdl.handle.net/11427/26926.
Full textGerrard, Simon Richard. "Novel nucleotide analogues for forming stable DNA triple helices." Thesis, University of Southampton, 2009. https://eprints.soton.ac.uk/69835/.
Full textHüsler, Paul L. "Thermodynamic characterization of DNA Triple-Helical three-way junctions." Doctoral thesis, University of Cape Town, 1995. http://hdl.handle.net/11427/18282.
Full textTrkulja, Ivan. "Triple helical DNA containing non-nucleosidic polyaromatic building blocks /." Bern : [s.n.], 2007. http://www.zb.unibe.ch/download/eldiss/07trkulja_i.pdf.
Full textTailor, Radha. "DNA triplexes in chemistry, biology and medicine." Thesis, University of Southampton, 2011. https://eprints.soton.ac.uk/192831/.
Full textGiesbertz, Anna [Verfasser], Elmar [Akademischer Betreuer] Weinhold, and Antal [Akademischer Betreuer] Kiss. "Triple helix-targeted DNA methylation with DNA methyltransferase-oligodeoxynucleotide conjugates / Anna Giesbertz ; Elmar Weinhold, Antal Kiss." Aachen : Universitätsbibliothek der RWTH Aachen, 2018. http://d-nb.info/1187346918/34.
Full textGowers, Darren Matthew. "DNA triple helix formation at homopurine sites interrupted by pyrimidine residues." Thesis, University of Southampton, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264646.
Full textMoraru, Allen Ana-Ariana. "Studies on chemically modified oligonucleotides and on DNA triplexes." Thesis, University of Edinburgh, 1997. http://hdl.handle.net/1842/12683.
Full textSingleton, Scott F. Dervan Peter B. Dervan Peter B. "The thermodynamics of oligonucleotide-directed triple helix formation at single DNA sites /." Diss., Pasadena, Calif. : California Institute of Technology, 1995. http://resolver.caltech.edu/CaltechETD:etd-10242007-090557.
Full textAlmeida, Carina Marisa dos Santos. "Gold nanoparticle-DNA conjugates for oligonucleotide vectorization towards gene silencing." Master's thesis, Faculdade de Ciências e Tecnologia, 2011. http://hdl.handle.net/10362/6212.
Full textThe main objective of the work presented in this thesis was to develop a gene silencing system by taking advantage of the nanovectorization capability and optical properties of gold nanoparticles. The idea is based on the construction of a DNA structure containing a therapeutic oligonucleotide with the ability to form Hoogsteen hydrogen bonds with double-stranded DNA, producing a DNA triple helix, besides silencing the gene of interest. Hoogsteen bonds, more unstable than the conventional Watson-Crick bonds, permit the achievement of lower melting temperatures. This attribute, coupled with the ability to generate heat by laser irradiation of the gold nanoparticles used, will allow the release of the therapeutic oligonucleotide and subsequent gene silencing without significant increase in the medium’s temperature. Thus, the thesis comprises three major sections: structure design and formation, vectorization, and gene expression silencing; the tasks involved in each of these sections were conducted in parallel. The design of the obtained structure took into account the desired melting temperature, stability at physiological conditions of the sequence-forming nucleotides, the number of Hoogsteen bonds and ionic conditions. To evaluate the formation of this structure, spectroscopic techniques were mainly used: FRET analysis and ultraviolet melting curves. Both approaches allowed the identification of interactions in the presence of therapeutic oligonucleotide compared with its absence, which may indicate structure formation. In addition, melting curves allowed the determination of the temperature of release of this oligonucleotide – 40ºC. The double-stranded DNA functionalization to gold nanoparticles has been achieved, but there was no difference in electrophoretic migration when the three oligonucleotides were present. However, the therapeutic oligonucleotide was able to efficiently inhibit gene expression in in vitro transcription and translation assays with efficiency up to 95% and 60% respectively.
Mei, Ivy Yuhua. "Triple helix formation between a short DNA hairpin molecule and linear single stranded oligonucleotides." Thesis, Georgia Institute of Technology, 1995. http://hdl.handle.net/1853/25346.
Full textBijapur, Jeevan. "Factors affecting the stability of nucleic acids." Thesis, University of Southampton, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299497.
Full textWeber, Zachary Thomas. "Applications of ctDNA Genomic Profiling to Metastatic Triple Negative Breast Cancer." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1586787923790178.
Full textBraich, Ravinderjit Singh. "Branched nucleic acids novel probes for studying pre mRNA processing and triple helical DNA." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0030/NQ64523.pdf.
Full textVölker, Jens. "The impact of global and local composition on the stability of Triple Helical DNA." Doctoral thesis, University of Cape Town, 1993. http://hdl.handle.net/11427/21828.
Full textDarian, Eva. "Triplex formation as monitored by EPR spectroscopy and molecular dynamics studies of spin-probe labeled DNAs." Morgantown, W. Va. : [West Virginia University Libraries], 2002. http://etd.wvu.edu/templates/showETD.cfm?recnum=2591.
Full textTitle from document title page. Document formatted into pages; contains xi, 121 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 113-115).
Göckel, Anja [Verfasser]. "Bindungsmotive zur molekularen Erkennung von Nikotinamid-Cofaktoren auf der Basis von DNA-Triplexen / Anja Göckel." München : Verlag Dr. Hut, 2017. http://d-nb.info/1135596271/34.
Full textBuchini, Sabrina. "2'-O-Aminoethyl-oligoribonucleotides in DNA triple-helix formation : extending the sequence recognition code to three base pairs /." [S.l.] : [s.n.], 2004. http://www.zb.unibe.ch/download/eldiss/04buchini_s.pdf.
Full textPuchrík, Matej. "Simulace Triple play služeb v pasivních optických sítích v prostředí OMNeT++." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2015. http://www.nusl.cz/ntk/nusl-220390.
Full textBakalara, Norbert. "Caracterisation dans le genome d'un annelide polychete : owenia fusiformis, d'une region comprenant la repetition du triplet nucleotidique ccx." Aix-Marseille 2, 1987. http://www.theses.fr/1987AIX22121.
Full textGranzhan, Anton. "Synthesis and studies of annelated quinolizinium derivatives as versatile constructs for fluorescent probes and ligands for triple helical and abasic DNA structures." [S.l.] : [s.n.], 2006. http://www.ub.uni-siegen.de/epub/diss/granzhan.htm.
Full textChen, Xiaomi. "Aberrant DNA Replication at an Ectopic Chromosomal Site in Human Cells." Wright State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=wright1302884072.
Full textChen, Yen-Shan. "MAMMALIAN TESTIS-DETERMINING FACTOR SRY HAS EVOLVED TO THE EDGE OF AMBIGUITY." Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1372888881.
Full textSugita, Bruna Mayumi. "Análise integrada do padrão de expressão de microRNAS e alteração do número de cópias de DNA em tumores de mama triplo-negativos." reponame:Repositório Institucional da UFPR, 2014. http://hdl.handle.net/1884/37077.
Full textCo-orientadores : Profª Drª Luciane R. Cavalli, Prof. Dr. Iglenir J. Cavalli
Dissertação (mestrado) - Universidade Federal do Paraná, Setor de Ciências Biológicas, Programa de Pós-Graduação em Genética. Defesa: Curitiba, 28/03/2014
Inclui referências
Área de concentração: Genética
Resumo: Os microRNAs (miRNAs) são uma classe de moléculas de RNA não codificadoras que apresentam um papel na tumorigênese mamária, regulando genes envolvidos no ciclo celular, proliferação celular, invasão e metástase. Os diferentes subtipos de câncer de mama apresentam diferentes padrões de expressão de miRNAs, dessa forma essas moléculas podem ser potenciais marcadores terapêuticos para subtipos agressivos, como os tumores mamários triplo negativos (TN). Os tumores TN são clinicamente agressivos e possuem baixa ou nenhuma expressão dos receptores de estrogênio (ER), progesterona (PR) e HER2, dessa forma não respondem efetivamente a terapias alvos disponíveis atualmente. No presente trabalho, foi analisado o padrão de expressão de miRNAs de 83 tumores TN e 12 não-TN, juntamente com dados de alterações de números de cópias de DNA por array-CGH obtidos das mesmas amostras, a fim de identificar os miRNAs mais relevantes e seus respectivos genes alvos que podem estar envolvidos na patogênese dos tumores de mama TN. 117 miRNAs foram encontrados com expressão diferencial em tumores TN, quando comparados com os não-TN. A análise combinada de miRNA/aCGH resultou em 17 miRNAs que apresentaram dados concordantes de expressão de miRNA e alterações de números de cópias (ganho/perda de aCGH com alta/baixa expressão de miRNA, respectivamente). Análises de sistemas biológicos downstream de alvos conhecidos e possíveis alvos dos miRNAs selecionados indicaram as vias de sinalização do TGF-beta, PI3K-Akt e HER2, assim como vias envolvidas na adesão celular e outros processos relacionados ao câncer. Estes resultados sugerem que os 17 miRNAs e seus respetivos genes alvos podem ser futuramente estudados como marcadores moleculares específicos para tumores TN, sugerindo a necessidade de estudos de análise funcional e biológica que comprovem suas participações na tumorigênese mamária de tumores do tipo TN.
Abstract: MicroRNAs (miRNAs) are a class of non-coding endogenous RNA molecules that play a role in breast tumorigenesis regulating genes involved in cell cycle, proliferation, invasion and metastasis. Different subtypes of breast cancer presents different expression of miRNAs, and they can be potential therapeutic markers for aggressive subtypes as triple negative breast cancers (TNBC). TNBC are clinically aggressive tumors that lack the expression of ER, PR and HER2 receptors, therefore they do not respond effectively to the available target therapies. In the present study, we investigated miRNA expression pattern of 83 TNBC and 12 non-TNBC tumors and integrated the data with DNA copy number alterations data by array-CGH from the same samples, to obtain the most relevant miRNAs and their respective target genes that may be involved in the pathogenesis of TNBC. 117 miRNAs were found as differentially expressed in TNBC, when compared to non-TNBC. The combined analysis (miRNA/aCGH) resulted in 17 miRNAs that presented miRNA concomitant genomic gains and losses by aCGH and miRNA increase or decrease expression, respectively. KEGG pathway enrichment analysis of the selected 17 miRNAs revealed that their main pathways involved in TGF-beta signaling pathway, PI3K-Akt and HER2 signaling pathways as well as the ones involved in adherence junction and other cancer related processes. Our results suggest that the 17 miRNAs and their target genes may be studied as specific molecular markers for TNBC, suggesting the need for functional and biological analysis that proves their roles in TN tumorigenesis.
Sirivolu, Venkata Ramana. "DNA containing side chains with terminal triple bonds: Synthesis, base pairing and functionalization of nucleosides and oligonucleotides by the azide-alkyne cycloaddition = DNA mit Terminalen Dreifachbindungen in Seitenketten: Synthese, Basenpaarung und Funktionalisierung von Nucleosiden und Oligonucleotiden durch die Azid-Alkin Cycloaddition /." Osnabrück, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000254558.
Full textNosek, Ondřej. "Hardwarová akcelerace algoritmu pro hledání podobnosti dvou DNA řetězců." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2007. http://www.nusl.cz/ntk/nusl-236882.
Full text