Dissertations / Theses on the topic 'DNA binding studies'
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Umurtak, H. B. "Studies on DNA-binding peptides]." Thesis, University of Southampton, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235192.
Full textRodríguez, Armando Chapin. "Structure-function studies of DNA-binding motors." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619565.
Full textKomori, Hirofumi. "Structural studies on DNA-binding proteins : DNA replication initiator and DNA photolyase." 京都大学 (Kyoto University), 2002. http://hdl.handle.net/2433/150005.
Full textDaly, Colette Lynn. "Binding studies using membrane electrodes." Thesis, University of Salford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252942.
Full textMenderin, Nathan. "Studies on the Human Sp1 DNA-Binding Domain." Thesis, University of Exeter, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.507135.
Full textHill, G. R. "NMR studies of DNA and RNA binding proteins." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604060.
Full textMaynard, Allister J. "NMR studies of protein folding and DNA binding." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313244.
Full textPovey, Jane. "Structural studies of the DNA-binding protein GAL4." Thesis, University of Cambridge, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385462.
Full textScarpantonio, Luca. "Studies of DNA binding of lanthanide platinum complexes." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/2860/.
Full textMack, Lynsey A. "Studies of extremophilic single-stranded DNA-binding proteins." Thesis, University of Edinburgh, 2005. http://hdl.handle.net/1842/12512.
Full textMojally, Mariam. "DNA binding studies of fluorinated bioactive heterocyclic compounds." Thesis, Loughborough University, 2015. https://dspace.lboro.ac.uk/2134/16732.
Full textBlomquist, Patrik. "Studies on nuclear factor 1 binding to nucleosomal DNA /." Stockholm, 1997. http://diss.kib.ki.se/1997/91-628-2633-6.
Full textLeonard, Philip Martin. "Structural studies on the LrpA protein from Pyrococcus furiosus." Thesis, University of Sheffield, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247186.
Full textPanjikar, Santosh. "Crystallographic studies of bacterial single stranded DNA-binding proteins." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=964154366.
Full textNkansah, Edwin. "In vitro studies of Stat3 dimerisation and DNA binding." Thesis, University of London, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540223.
Full textIsaac, Christian James. "Redox active metal complexes : synthesis and DNA binding studies." Thesis, University of Newcastle Upon Tyne, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287813.
Full textScott, Nerida Robyn. "Folding studies of the glucocorticoid receptor DNA-binding domain." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627279.
Full textSchmiedeskamp, Mia Ruth. "NMR studies of the DNA-binding domain of ADR1 /." Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/9208.
Full textLow, Lieh Yoon. "Thermodynamic studies of zinc binding and stability of nuclear hormone receptor DNA-binding domains." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620310.
Full textMassad, Tariq. "Structural Studies of Flexible Biomolecules and a DNA-binding Protein." Doctoral thesis, Stockholms universitet, Institutionen för biokemi och biofysik, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-42009.
Full textAt the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 4: In press. Paper 5: Manuscript.
Novac, Olivia. "Studies on origin binding proteins involved in mammalian DNA replication." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=83084.
Full textHere, the in vivo association of Ku and 14-3-3 with mammalian origins of DNA replication was analyzed by studying its association with the monkey (CV-1) replication origins ors8 and ors12, by formaldehyde cross-linking, followed by chromatin immunoprecipitation (Chip) and quantitative PCR analysis. The involvement of 14-3-3 in mammalian DNA replication was also analyzed by studying the effect of anti-14-3-3beta, epsilon, gamma, and zeta antibodies in the in vitro replication of p186, a plasmid containing the minimal replication origin of ors8.
Ku and 14-3-3beta, epsilon, gamma, zeta and sigma isoforms were found to be associated with mammalian origins of DNA replication and their association was the highest in cells synchronized at the G1/S phase of the cell cycle. In addition, Anti-14-3-3epsilon, gamma and zeta antibodies inhibited p186 replication by approximately 30--80%.
The Ku80 mutant (xrs-5) and deficient (Ku80-/- MEFs) cell lines were also tested for their ability to replicate p186, in vitro. Whole cell (WCE) and cytoplasmic cell extracts from the xrs-5 cells replicated p186 with the same efficiency as are wild-type (wt) CHO K1 cells. In contrast, xrs-5 nuclear extracts did not possess any detectable replication activity, while the Ku80 -/- WCE had a decrease of ~70% in their ability to support p186 replication, by comparison to the wt Ku80-/- extracts. Furthermore, in vivo, the p186 episomal DNA replication in transfected xrs-5 cells was reduced by 45% by comparison to CHO K1 cells.
The in vivo association of Ku with the Chinese hamster DHFR oribeta or the mouse Adenosine deaminase (ADA) origins of DNA replication was examined in both the Ku80 mutant (xrs-5) and deficient (Ku80-/-) cell lines, and in their respective wild-type counterparts. Anti-Ku antibodies failed to immunoprecipitate a detectable amount of Ku from the either xrs-5 or Ku80-/- cells in the origin-containing-sequence, in contrast to the wild type cells, wherein Ku was found to be associated with the oribeta and ADA origins, respectively.
The data implicate Ku antigen in DNA replication and suggest the existence of another protein in rodent cells that is able to substitute for Ku function. They also indicate a novel function for Ku and the 14-3-3 isoforms beta, epsilon, gamma, zeta and sigma, as origin-binding-proteins in vivo, which provides a better understanding of the chromosomal association and DNA binding sequences of mammalian initiator proteins with origins of replication in their natural chromosomal environment.
Phillips, Tim. "DNA Binding and Photophysical Studies on Organic Derivatives of Dipyridophenazine." Thesis, University of Sheffield, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.489744.
Full textMunnur, Deeksha Ganesh. "Structural studies of DNA complexes with minor groove-binding drugs." Thesis, University College London (University of London), 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.550498.
Full textJones, Gareth. "NMR studies of the DNA-binding domain of B-Myb." Thesis, University of Kent, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270703.
Full textHobbs, Jeanette Roseanna. "Structural studies on the DNA binding modes of topoisomerase poisons." Thesis, University of Reading, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342117.
Full textVitorino, Susana Ricardo. "Rhodium(III) supramolecular complexes : synthesis, DNA binding and biological studies." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/2814/.
Full textSchechner-Resom, Martina Gabriele. "Ligand binding and molecular flexibility : Studies on DNA gyrase B." Université Louis Pasteur (Strasbourg) (1971-2008), 2005. http://www.theses.fr/2005STR1A001.
Full textDNA gyrase is a vital bacterial enzyme necessary for the handling of the large DNA molecules in the living cell. Therefore DNA gyrase is an ideal target enzyme for anti-infectious compounds. In this work DNA gyrase has been studied by molecular modelling methods. A computational structure-based ligand design approach has been carried out on the N-terminal 24 kDa subdomain of DNA gyrase B (GHKL domain). To further examine the flexibility of two active site loops, molecular dynamics simulations have been carried out on the GHKL domain in different ligand binding conditions. In a final part, normal mode analysis has been carried out on the dimer of the 43 kDa domain of DNA gyrase B
Stracy, Mathew. "Single-molecule studies of DNA-binding proteins in live bacteria." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:d2b6ad0a-0fd4-4742-9ca2-dc13ba95f267.
Full textZhong, Shan. "Studies on the human homolog of the yeast Noc3p in human cells /." View abstract or full-text, 2004. http://library.ust.hk/cgi/db/thesis.pl?BICH%202004%20ZHONG.
Full textIncludes bibliographical references (leaves 83-100). Also available in electronic version. Access restricted to campus users.
Deegan, Brian J. "Biophysical Studies of the Binding of ERα Nuclear Receptor to DNA." Scholarly Repository, 2011. http://scholarlyrepository.miami.edu/oa_dissertations/579.
Full textDutnall, Robert Nicholas. "Structural and functional studies of a zinc finger DNA-binding domain." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360030.
Full textRajput, Chatna. "Synthesis and binding studies of DNA duplex and quadruplex interactive ligands." Thesis, University of Sheffield, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425171.
Full textMcIntosh, Pauline Bernadette. "NMR based studies of the DNA-binding domain from B-Myb." Thesis, Open University, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388299.
Full textNorman, Jenna Anne. "Functionalised iron(II) supramolecular helicates : design, synthesis and DNA binding studies." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4088/.
Full textAlonso, Natalia Calle. "Tetra-stranded metallo-supramolecular cylinders : design, synthesis and DNA binding studies." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4053/.
Full textNordzell, Mariette. "Functional studies on the nuclear receptor Nurr1 /." Stockholm : Karolinska institutet, 2004. http://diss.kib.ki.se/2004/91-7349-867-X/.
Full textVaughan, P. J. "Studies on a component of the herpes simplex virus DNA polymerase." Thesis, University of Leeds, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379648.
Full textParkinson, John Andrew. "NMR studies on the Met J operator from Escherichia coli." Thesis, University of Leeds, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328964.
Full textJohnson, Vinu. "Structural and Biophysical Studies of Single-Stranded DNA Binding Proteins and dnaB Helicases, Proteins Involved in DNA Replication and Repair." University of Toledo / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1198939056.
Full textWilson, Dale F. "Synthesis, Characterization, DNA Binding and Photocleavage Studies of a Di-Ruthenated Porphyrin." University of Dayton / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1398882510.
Full textLee, Myung Soo. "Studies on the DNA helicase activities of the Escherichia coli primosome : involved in DNA replication fork movement /." Access full-text from WCMC, 1989. http://proquest.umi.com/pqdweb?did=744115351&sid=1&Fmt=2&clientId=8424&RQT=309&VName=PQD.
Full textSiu, Kit-man Phyllis. "Luminescent cyclometalated platinum(II) complexes : protein binding studies and biological applications /." View the Table of Contents & Abstract, 2005. http://sunzi.lib.hku.hk/hkuto/record/B30575357.
Full textKantola, Angeline R. "Nuclear magnetic resonance studies of the xUBF Box 1 DNA binding domain /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/9228.
Full textHermanson, Elisabet. "Studies on the nuclear receptor Nurr1 : identification of Nurr1-regulated genes /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-833-5/.
Full textRaber, Johan. "Quantum Chemical Studies of Chemotherapeutic Drug Cisplatin : Activation and Binding to DNA." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7824.
Full textMok, Yu-Keung. "Studies on the DNA binding domain human papillomavirus strain 16 E2 protein." Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264157.
Full textSwanson, Gary Robert. "Expression, characterisation and n.m.r. studies of the DNA-binding domain of SW15." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240054.
Full textWilliamson, Josephine. "Studies of the DNA mismatch binding proteins MutS, VSR and CEL I." Thesis, University of Southampton, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403846.
Full textKoorsen, Gerrit. "Studies of the binding of linker histone H5 to DNA and chromatin." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613656.
Full textZhang, Jinjin. "Structural Studies of Escherichia coli RecE Exonuclease." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1254972783.
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