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Dissertations / Theses on the topic 'DMT1'

Author: Grafiati

Published: 4 June 2021

Last updated: 27 April 2022

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1

Tchernitchko, Dimitri. "Études moléculaires de DMT1, un transporteur membranaire du fer." Paris 7, 2002. http://www.theses.fr/2002PA077183.

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2

Rivas, Romero Daniela Paz. "Modelación molecular y estudio de la isoforma 1A/IRE(+) de la proteína DMT1 humana." Tesis, Universidad de Chile, 2015. http://repositorio.uchile.cl/handle/2250/137489.

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Ingeniera Civil en Biotecnología<br>En distintos estudios se ha determinado que mutaciones en la proteína transportadora DMT1, encargada de transportar hierro desde el lumen intestinal hacia los enterocitos, son causantes de distintos tipos de anemia, no obstante, poco se conoce sobre su estructura tridimensional y su mecanismo de transporte. Por esta razón, el objetivo del presente trabajo es obtener un modelo estructural de la isoforma 1A/IRE(+) de la proteína DMT1 humana y a partir de éste estudiar el posible comportamiento de la proteína inserta en membrana. La predicción de dominios tran

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3

Colins, Rodríguez Andrea Justina. "Determinación experimental y modelación matemática de los flujos de transporte de hierro en células Caco-2." Tesis, Universidad de Chile, 2015. http://repositorio.uchile.cl/handle/2250/135289.

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Magíster en Ciencias de la Ingeniería, Mención Química<br>Ingeniera Civil en Biotecnología<br>El hierro es un metal traza, fundamental para la existencia de la vida. Los niveles de hierro en el organismo deben ser altamente controlados ya que pequeñas variaciones desencadenan numerosas enfermedades, entre ellas la anemia y hemocromatosis. En seres humanos la presencia de este metal se controla regulando su absorción intestinal, en donde el hierro ingresa al organismo a través de la proteína DMT1, ubicada en la cara apical de los enterocitos. Luego, el hierro es transportado a la cara basolater

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Sáez, Rojas Carla. "Modelamiento matemático del movimiento de transportadores de hierro en células caco-2." Tesis, Universidad de Chile, 2014. http://www.repositorio.uchile.cl/handle/2250/130324.

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Ingeniera Civil en Biotecnología<br>El hierro es un elemento fundamental para muchos organismos por las reacciones en las que se encuentra involucrado, y su absorción está altamente regulada por mecanismos a diferentes niveles. El transporte de hierro se realiza en el duodeno a través de proteínas transportadoras que se encuentran en la membrana apical de los enterocitos (DMT1, Divalent Metal Transporter 1). Uno de los mecanismos de regulación involucra la traslocación de estas proteínas hacia el interior de las células cuando éstas son expuestas a una cierta concentración de hierro en la cara

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Shawki, Ali. "The Functional Properties and Intestinal Role of the H⁺-Coupled Divalent Metal-Ion Transporter 1, DMT1." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1448037106.

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6

Salazar, Rivera Julio. "Altération du métabolisme du fer dans la maladie de Parkinson : participation du Transporteur 1 de Métaux Divalents (DMT1) et des Protéines Régulatrices du Fer (IRPs) dans la mort des neurones dopaminergiques de la Substantia Nigra Pars Compacta." Paris 6, 2008. http://www.theses.fr/2008PA066242.

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La maladie de Parkinson (MP) est caractérisée par la mort préférentielle et accélérée des neurones dopaminergiques de la substance noire (SN) dont la cause est inconnue. De nombreuses études ont montré une augmentation des taux de fer dans les neurones dopaminergiques mélanisés et dans les cellules gliales de cette structure. En raison de son rôle pro-oxidant, le fer pourrait être un des facteurs expliquant la mort massive des neurones dopaminergiques dans la MP. Des études post-mortem, réalisées au sein de notre laboratoire (INSERM UMR679), ont montré que les sites de liaison de la transferri

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7

Thomas, Carla. "The validation and use of the rat intestinal epithelial cell line 6 (IEC-6) to study the role of ferroportin1 and divalent metal transporter 1 in the uptake of iron from Fe(II) and Fe(III)." University of Western Australia. Physiology Discipline Group, 2003. http://theses.library.uwa.edu.au/adt-WU2004.0019.

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[Formulae and special characters can only be approximated here. Please see the pdf version of the abstract for an accurate reproduction.] Iron is vital for almost all living organisms by participating in a wide variety of metabolic processes, including oxygen transport, DNA synthesis, and electron transport. However, iron concentrations in body tissues must be tightly regulated because excessive iron leads to tissue damage, as a result of formation of free radicals. In mammals since no controlled means of eliminating unwanted iron has evolved, body iron balance is maintained by alterations i

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Kirui, Joseph Kiprono. "ESR study of DMTM(TCNQ)₂." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/29191.

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The ESR g-value and susceptibility measurements for DMTM(TCNQ)₂ have been studied as a function of angle made by crystal with magnetic field and temperature. The angular dependence of g-value is fitted to g² = α+βcos2θ - γsin2θ for three orthogonal directions of crystal rotation. The principal g-values are close to those expected for TCNQ compounds: g₁ = 2.0034, g₂ = 2.0030, g₃ = 2.0024. The susceptibility as a function of temperature agrees with bulk susceptibility measurements except that the maximum position occurs at about 30 K. The results of Oostra et al. for bulk susceptibility showed a

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9

Gomes, Carolina Pereira. "Reprodução em Characidium schubarti (Teleostei: Characiformes): análise da reprodução em cativeiro e de genes relacionados à diferenciação sexual (dmrt1, cyp19a1a e amh)." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/41/41131/tde-29052014-103655/.

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Os peixes teleósteos representam cerca de metade de todas as espécies de vertebrados já descritas. Esta rica diversidade reflete-se nas diferentes formas de determinação sexual, sendo as principais desencadeadas por influência ambiental e por fatores genéticos. Os genes envolvidos neste mecanismo têm sido caracterizados em diversas espécies de peixes teleósteos, como é o caso dos genes dmrt1 e amh que têm importante papel na diferenciação em machos de teleósteos e o gene cyp19a1a, que possui relação com a diferenciação sexual de fêmeas. Têm sido cada vez mais corrente na literatura, estudos en

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Xu, Yang. "Equalization algorithms for ADSL DMT system." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0004/MQ36756.pdf.

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11

Siyam, Arwa. "NUCLEAR LOCALIZATION OF DMP1 AND DSPP IN VARIOUS CELL LINES." Master's thesis, Temple University Libraries, 2012. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/183440.

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Oral Biology<br>M.S.<br>Objective: To examine Dentine matrix protein 1(DMP1) and Dentine sialophosphoprotein (DSPP) expression and subcellular localization in various cell lines to better understand their function. Methods: RT-PCR, immunofluorescent staining and Western-blotting analyses were used to determine the expression and subcellular localization of DMP1 and DSPP in various cell lines, including odontoblast-like (17IIA11), preosteoblast (MC3T3-E1), mesenchymal cells (C3H10T1/2), and human dental pulp stem cells (DPSC). In addition, a haemagglutinin (HA) tagged DMP1 expression construct

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Guan, Juan. "Investigations on natural silks using dynamic mechanical thermal analysis (DMTA)." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:c16d816c-84e3-4186-8d6d-45071b9a7067.

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This thesis examines the dynamic mechanical properties of natural silk fibres, mainly from silkworm species Bombyx mori (B. mori) and spider species Nephila edulis, using dynamic mechanical thermal analysis, DMTA. The aim is not only to provide novel data on mechanical properties of silk, but also to relate these properties to the structure and morphology of silk. A systematic approach is adopted to evaluate the effect of the three principal factors of stress, temperature and hydration on the properties and structure of silk. The methods developed in this work are then used to examine commerci

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Hägglund, Adel, and Suan Cing Nem. "Patienters erfarenheter av egenvård vid Diabetes Mellitus Typ 2 : Literaturstudie." Thesis, Högskolan i Gävle, Avdelningen för hälso- och vårdvetenskap, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-28823.

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Bakgrund: Diabetes typ 2 (DMT2) står för majoriteten av all diabetes i Sverige som internationellt, vilket har satts i samband med vår moderna livsstil, minskad fysisk aktivitet och en tilltagande ökning av kroppsvikt. Orsaken kan t.ex. relateras till patientens ärftliga betingad eller individens levnadsvanor. Egenvård är viktig för att förebygga eller minska senkomplikationer. Syftet: Syftet med det föreliggandeexamensarbetetvar attbeskriva vuxna patienters erfarenheter av egenvård vid DMT2samt granska datainsamlingsmetoder och urvalsgrupp använts i artiklarna. Metod: Litteraturstudieutförde

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14

Zhang, Liang. "Error control coding in ADSL DMT system." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0001/MQ36760.pdf.

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Solberg, Scott W. "Discipling Ministry Team (DMT) leadership development program /." Online full text .pdf document, available to Fuller patrons only, 2003. http://www.tren.com.

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Zhang, Liang. "Turbo coded modulation in ADSL DMT systems." Thesis, University of Ottawa (Canada), 2002. http://hdl.handle.net/10393/6308.

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A&barbelow;symmetric d&barbelow;igital s&barbelow;ubscriber l&barbelow;ine (ADSL) technology provides transport of high-bit-rate digital information over digital subscriber lines (i.e., common telephone lines), which were initially engineered to carry a single voice signal with a 3.4 kHz bandwidth. Sophisticated digital transmission techniques have to be utilized to overcome digital subscriber line transmission impairments due to the high signal attenuation, i&barbelow;nter-s&barbelow;ymbol i&barbelow;nterference (ISI), c&barbelow;rosst&barbelow;alk noise (XT) from the signals present on adjac

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Queiroz, Angela Custódia Guimarães. "Uso do DMT na avaliação de maciços compactados." reponame:Repositório Institucional da UnB, 2008. http://repositorio.unb.br/handle/10482/3649.

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xvi, 96 f. : il.<br>Submitted by Rosane Cossich Furtado (rosanecossich@gmail.com) on 2010-02-13T13:37:01Z No. of bitstreams: 1 2008_AngelaCustodiaGuimaraesQueiroz.pdf: 1833620 bytes, checksum: 70e6405d7e046ef42c1712d21ebaa262 (MD5)<br>Approved for entry into archive by Marília Freitas(marilia@bce.unb.br) on 2010-02-18T22:45:41Z (GMT) No. of bitstreams: 1 2008_AngelaCustodiaGuimaraesQueiroz.pdf: 1833620 bytes, checksum: 70e6405d7e046ef42c1712d21ebaa262 (MD5)<br>Made available in DSpace on 2010-02-18T22:45:41Z (GMT). No. of bitstreams: 1 2008_AngelaCustodiaGuimaraesQueiroz.pdf: 1833620 byte

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Silva, Fábio Krueger da. "Ensaios dilatométricos - DMT em solos de Santa Catarina." Florianópolis, SC, 2008. http://repositorio.ufsc.br/xmlui/handle/123456789/91917.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia Civil.<br>Made available in DSpace on 2012-10-24T03:52:29Z (GMT). No. of bitstreams: 1 254670.pdf: 15143619 bytes, checksum: b565e1d1c665e9060dfe45d0a6f696c3 (MD5)<br>É crescente a demanda mundial pela realização de ensaios geotécnicos de campo. Com os atuais avanços tecnológicos os ensaios geotécnicos têm sido rigorosamente indicados pelos projetistas para investigação do subsolo. O ensaio Dilatômetro de Marchetti (DMT) vem sendo amplamente utilizado em todo mundo, com

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Singh, Gunjita. "Role of recombinaison proteins in crossover formation, pairing and synapsis in Arabidopsis meiosis : Physiologie et génétique moléculaires." Thesis, Université Clermont Auvergne‎ (2017-2020), 2017. http://www.theses.fr/2017CLFAC037/document.

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Manifestation visible des cross-overs génétiques, les chiasmata lient les paires de chromosomes homologues afin de les orienter correctement sur le fuseau méiotique en Métaphase et Anaphase I. Ils résultent d'un processus complexe et étroitement régulé impliquant l'induction de cassures double-brins et de leur réparation par l'invasion d'un duplex d'ADN homologue faisant office de modèle. La recombinaison est ainsi essentielle pour le synapsis et la ségrégation correcte des chromosomes méiotiques à la première division méiotique, et pour la génération de la variabilité génétique. Bien que les

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AMIN, AHMED. "Implementation and Investigation of VDSL2 Signal Modulation/Demodulation Functions for FDM Solution via POF Channel." Thesis, Högskolan i Gävle, Avdelningen för elektronik, matematik och naturvetenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-10766.

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For higher data rate and attractive price level internet service Very High Data rate Subscriber Line 2 (VDSL2) is a perfect option. VDSL2 is a great achievement in Digital Subscriber Line (DSL) technology. It has a good impact in modern triple play (Voice, Data and Video) Internet service but for modern world applications required more data rate than the VDSL2 system can provide but it should be inexpensive and easy to install. So the desired goal of this thesis work is to achieve higher bitrates for VDSL2 system, by transmitting multiple VDSL2 signal using Plastic Optical Fiber (POF) channel

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Istanbulluoglu, Ipek. "A Novel Modeling Methodology And Performance Improvement Technique For Dmtl Phase Shifters." Master's thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/2/12607522/index.pdf.

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This thesis presents distributed MEMS transmission line (DMTL) phase shifters, emphasizing the circuit modeling and design as well as the performance improvement. A novel modeling methodology is introduced for DMTL unit sections, with bridge widths larger than 50 &amp<br>#956<br>m. The introduced model is compared with EM simulation results and the CLR modeling results. For structures with bridge widths larger than 50 &amp<br>#956<br>m, the introduced model fits the simulation results much better than the CLR model. The simulated structures are fabricated in METU micro-electronics facilitie

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George, Susan. "The distribution of DMC1 epitopes in lilies with normal and aberrant meioses." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ58737.pdf.

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Lu, Yongbo Feng Jian Q. "Studies of dentin matrix protein 1 (DMP1) regulation and function in vivo." Diss., UMK access, 2007.

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Thesis (Ph. D.)--School of Dentistry. University of Missouri--Kansas City, 2003.<br>"A dissertation in oral biology and molecular biology and biochemistry." Advisor: Jian Q. Feng. Typescript. Vita. Title from "catalog record" of the print edition Description based on contents viewed July 16, 2008. Includes bibliographical references (leaves 109-121). Online version of the print edition.

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Fullerton, Donna Lynn. "Investigation of the expression of DMC1, a meiotic gene, in trichomonas vaginalis." Scholarly Commons, 2007. https://scholarlycommons.pacific.edu/uop_etds/664.

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T. vaginalis is a protozoan parasite without an observed sexual stage in its life cycle. However, T. vaginalis has genes, such as Dmc1, known to be involved in meiosis in other organisms. In order to look at the expression of these genes in T. vaginalis, RT-PCR was done using purified mRNA. It shows that Dmc1 is expressed in both normal and drug treated cells. However, relative levels are unclear. Localization studies were done in T. vaginalis using immunofluorescence against Dmc1 protein with an HA tag. These studies showed that recombinant Dmc1 remained in the cytoplasm upon treatment with D

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Belloli, Marcus Vinicius Alves. "Interpretação de ensaios DMT em solos com drenagem parcial." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2018. http://hdl.handle.net/10183/181399.

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Entre os objetivos da engenharia geotécnica está a busca pelo entendimento e previsão do comportamento mecânico dos solos. Para isso, existem basicamente duas abordagens: ensaios de laboratório ou ensaios de campo. Em cada obra o Engenheiro Geotécnico deve julgar quais são os métodos e procedimentos mais indicados de investigação, que resultarão em parâmetros confiáveis de projeto. Os ensaios de campo foram desenvolvidos baseados nos solos argilosos e arenosos em virtude dos comportamentos distintamente bem definidos, especialmente em termos de drenagem. O mesmo ocorre para o ensaio DMT, cuja

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Mateus, Cárin Cristina de Almeida. "Determinação dos erros de medição associados ao ensaio DMT." Master's thesis, Universidade de Aveiro, 2008. http://hdl.handle.net/10773/2716.

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Mestrado em Engenharia Geológica<br>A evolução tecnológica verificada sobretudo nos últimos 20 anos revolucionou de forma drástica o contexto da prática da engenharia, nomeadamente pelo desenvolvimento de modelos numéricos de elevada precisão e fiabilidade, que facilitam a simulação de comportamentos e de soluções de engenharia. A eficiência e a qualidade dos resultados desses modelos estão intrinsecamente relacionadas com a selecção dos parâmetros de entrada, os quais dependem sobretudo da qualidade dos equipamentos de medição, da sua adequabilidade a cada situação particular e dos erros asso

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Santos, Neife Aparecida Guinaim dos. "Efeito da cisplatina na função, estresse oxidativo e estado redox mitocondrial renal em ratos: efeito protetor da dimetiltiouréia." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/60/60134/tde-22052007-091457/.

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Embora a cisplatina (cis-diaminocloroplatina II) seja um efetivo agente anticâncer, seu uso clínico é altamente limitado, predominantemente devido ao seu potencial nefrotóxico. Muitos estudos têm demonstrado que a cisplatina causa disfunção mitocondrial em células epiteliais renais e danos ao DNA nuclear devido à ação de espécies reativas de oxigênio tais como superóxido e radicais hidroxila. O aumento na produção destas espécies de oxigênio causa liberação de citocromo c no citosol, iniciando uma cascata de eventos que leva à morte celular por apoptose. A proteção seletiva da mitocôndria cont

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Yadav, Pankaj. "Time and thermo-mechanical coupling effects in polymers." Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTS061.

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L'étude du comportement mécanique et thermique des polymères est d'une importance capitale pour les applications techniques. Par conséquent, la capacité de prédire ces propriétés pour des plages étendues de fréquences de sollicitation et de température, est une forte motivation. Sur la base d'une combinaison expérimentale d'analyses rhéologiques mécaniques et thermiques (DMTA), des modèles phénoménologiques sont ainsi développés pour prédire le comportement viscoélastique linéaire des polymères avec l'utilisation traditionnelle du principe dit de "superposition temps-température (TTSP)". Lors

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Banville, Isabelle. "Étude des caractéristiques biochimiques et structurales de la protéine DMC1 de Schizosaccharomyces pombe." Thesis, Université Laval, 2004. http://www.theses.ulaval.ca/2004/22203/22203.pdf.

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Peu de données sont connues à savoir comment des protéines méiotiques régulent la recombinaison homologue de façon biochimique. Lors d'études effectuées chez l'humain, il a été démontré que hRad51 se comporte sensiblement comme le fait son homologue bactérien, RecA. Malgré que hDmc1 possède une séquence d’acides aminés possédant 52% d’identité à celle de hRad51, ses caractéristiques et ses capacités sont différentes. Afin d’étudier si cette disparité est conservée chez l'organisme Schizosaccharomyces pombe nous avons purifié et étudié biochimiquement la protéine Dmc1 de cet organisme. Nous m

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Marceau, Jean-François. "Low-complexity echo cancellers for DMT-based asymmetric DSL transceivers." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=83875.

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In the past years, a number of researchers have investigated the use of digital echo cancellation systems for transmission technologies based on discrete multi-tone (DMT) modulation, such as that used in asymmetrical digital subscriber lines (ADSL) and the likes. Almost all the existing papers report on equal transmission rate systems, while little attention has been given to the multi-rate case. In fact, the first multi-rate echo canceller structure was developed by Ho et al., and has always been referred since.<br>In this thesis, two sets of simplified techniques are developed. The fi

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Zhang, Junjie. "Mechanisms of resistance toT-DM1 in HER2-positive breast cancer." Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/650489.

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El cáncer de mama HER2-positivo representa alrededor del 15-30% del total de pacientes con cáncer de mama. Este subtipo tiene un mal pronóstico, seguido del subtipo Triple-negativo (TNBC), que lo tiene aún peor. Actualmente, varios medicamentos están aprobados para las pacientes HER2-positivo, como Trastuzumab, Lapatinib y T-DM1. Sin embargo, a menudo éstas adquieren resistencia a estas terapias en un período de 1 a 2 años. El objetivo principal de este estudio es definir los mecanismos de resistencia a T-DM1. Durante mi tesis, generé líneas celulares resistentes a T-DM1 y exploré diferentes p

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Sauveur, Juliette. "Development and characterization of models of resistance to T-DM1." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1266/document.

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Le T-DM1 est un immunoconjugué composé de l'anticorps trastuzumab qui cible HER2 lié au DM1, un agent anti-tubuline dérivé de la maytansine. Malgré son efficacité, la résistance acquise au T-DM1 a été démontré lors des tests précliniques et chez certains patients. Nous avons développé des lignées résistantes à partir de la lignée de cancer du sein MDA-MB-361 et de la lignée de cancer de l'œsophage OE-19, que nous avons exposées au T-DM1 à doses croissantes pendant une longue durée en absence ou en présence de ciclosporine A (CsA). A partir de ces conditions nous avons obtenus les lignées “TR”

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Průša, Jaromír. "Využití DMT při návrhu ochrany a organizace povodí Děrenského potoka." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2012. http://www.nusl.cz/ntk/nusl-225393.

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The theme of the work is the creation of the characteristics of the erozních and drainage conditions in the cadastral territory of the commune and the subsequent proposal Kujavy erosion control measures. Analysis of erozion ratios was processed using GIS method of the grid. Characteristics of runoff ratios was carried out for major service area of the critical points (SPKB) using model DesQ and numbers of the CN. In the design of erosion control measures was drawn up in the economic evaluation.

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Moran, Lopez Natalia Isabel. "Effects of Ethinylestradiol, EE2, exposure on Poecilia reticulta male specific genes, DMRT1 and CYP11b." Thesis, Södertörns högskola, Institutionen för livsvetenskaper, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-12356.

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Endocrine disrupting chemicals (EDCs) found in every day product, can either be natural or man-made and usually exists in a concerning concentration in our aquatic environment which in turn could affect teleost reproduction. EDCs exposure in fishes may result in changes in their reproductive physiology and morphology resulting in for example induction in gonopodia in female fish when exposed to androgens and in males exposed to female estrogen a reduced sperm count and skewed sex ration. Exposures during development have effects on organisms that are permanent and irreversible. Exogenous estro

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Devisetty, Upendra Kumar. "Molecular investigation of RAD51 and DMC1 homoeologous genes of hexaploid wheat (Triticum aetivum L.)." Thesis, University of Nottingham, 2010. http://eprints.nottingham.ac.uk/13340/.

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Meiotic recombination in eukaryotes requires two orthologues of the E. coli RecA proteins, Rad51 and Dmc1. Both genes play an important role in the binding of single strand DNA, homology search, strand invasion and strand exchange resulting in Holliday junctions which are resolved into crossovers or non-crossovers events. Even though both genes are well characterized in a variety of organisms including plants, very little information is available from hexaploid wheat. In most diploid plant species, deletion of either the RAD51 or DMC1 orthologues leads to sterility but wheat being a polyploid,

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Polley, Shamik. "The genetic structure, function and relevance to disease of the salivary agglutinin gene (DMBT1)." Thesis, University of Leicester, 2015. http://hdl.handle.net/2381/31400.

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Salivary agglutinin, encoded by the gene DMBT1, is a multifunctional high molecular mass glycoprotein (340 kDa) that acts as a pattern recognition receptor (PRRs) in innate immunity and mediates epithelial differentiation. The central region of the protein contains 13 tandemly-repeated scavenger receptor cysteine-rich (SRCR) domains that are copy number variable and bind to bacteria and viruses. The paralogue ratio test (PRT) was used to estimate the exact copy number of two distinct CNV (1 & 2) regions of DMBT1 gene and results were compared with other CNV estimation assays. Both CNV1 and CNV

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Tavares, Lidiane Silva. "Investigação de alcaloides ß-carbolinas, Triptaminas presentes na Ayahuasca (Santo Daime) em amostras de suor." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/60/60134/tde-30102014-162441/.

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Os alcaloides ß-carbolinas, Harmina e Harmalina, e o potente alucinógeno N, N-dimetiltriptamina são os principais componentes da Ayahuasca, uma bebida típica, utilizada na forma de chá e amplamente empregada em rituais religiosos na América do Sul. Embora seu uso ocorra desde períodos pré-colombianos ainda são poucas as informações sobre suas possíveis aplicações clínicas, assim como seus efeitos toxicológicos. Nos últimos anos, o uso da Ayahuasca se difundiu para vários países: Estados Unidos, Alemanha, Inglaterra, França e Espanha, com isso houve o aumento do interesse em estudos científicos

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Conde, Marcus Cristian Muniz. "Obtenção de RNA odontoblástico de alta qualidade após o armazenamento de dentes em diferentes condições de temperatura." Universidade Federal de Pelotas, 2010. http://repositorio.ufpel.edu.br/handle/ri/2277.

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Made available in DSpace on 2014-08-20T14:30:15Z (GMT). No. of bitstreams: 1 Dissertacao_ Marcus_Cristian_Muniz_Conde.pdf: 970527 bytes, checksum: a12676103871857eca97235b488f90c1 (MD5) Previous issue date: 2010-04-30<br>Isolate high quality RNA form dental tissues is a most critical step to perform gene expression analysis. In some situations it is impossible to achieve the RNA isolation after tooth extraction, which leads to tooth discarding. Since, the aim of this experiment was to verify the effect of different teeth storage methods in the quality of RNA obtained from freshly extracted

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Gasnier, Erwan. "Expansion de triplets CTG et arrêt prolifératif précoce des myoblastes DM1." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2012. http://tel.archives-ouvertes.fr/tel-00829312.

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La dystrophie myotonique de type I est la pathologie neuromusculaire la plus répandue chez l'adulte. Elle est caractérisée par une atteinte multisystémique plus ou moins prononcée en fonction de l'extension des répétitions CTG, mutation à l'origine de l'atteinte. Le muscle squelettique est particulièrement touché avec un phénomène de myotonie ainsi qu'une atrophie. Les myoblastes, à l'origine de la formation des muscles et de leur régénération potentielle, présentent, chez les patients DM1, une capacité proliférative limitée par rapport à des myoblastes issus d'individus sains. C'est l'activat

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Zimmermann, Eva. "Assoziation von funktionell wirksamen Polymorphismen im humanen DMBT1-Gen mit der Pathogenese der chronischen Parodontitis." Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-158507.

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Le, Bras Emanuelle. "Die Rolle von DMBT1-Polymorphismen auf die Suszeptibilität und den Phänotyp von chronisch entzündlichen Darmerkrankungen." Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-161747.

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El, Zaiat Maëva. "Cibles et voies de signalisation régulées par FOXL2 au cours de la morphogenèse ovarienne." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS035/document.

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FOXL2 est un facteur de transcription crucial pour la fonction ovarienne. Dans l'espèce humaine, des mutations hétérozygotes de ce gène sont responsables de la survenue d'un syndrome associant des malformations des paupières à une insuffisance ovarienne prématurée. De même chez la souris, l'invalidation totale de Foxl2 conduit à un blocage de la folliculogenèse et donc à une infertilité femelle. Chez la chèvre, la mutation Polled Intersex Syndrome (PIS) engendre le silence transcriptionnel de FOXL2 dans les gonades XX PIS-/- ce qui conduit à une inversion sexuelle et à la différenciation de te

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Sosnoski, Jonatas. "Interpretação de ensaios de CPTU e DMT em solos com permeabilidade intermediária." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2016. http://hdl.handle.net/10183/156352.

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A indústria mineradora do país sofre constantemente com problemas ambientais devido à qualidade e volume de rejeitos gerados durante o processo de extração do minério. Os volumes gerados demandam grandes áreas para armazenagem e consequentemente obras complexas de contenção dos rejeitos. A engenharia geotécnica busca entender o comportamento mecânico de depósitos destes rejeitos através do uso de ensaios tanto de campo como de laboratório. Para isso utiliza ferramentas e procedimentos consagrados no meio técnico seguindo normas e procedimentos estabelecidos e consagrados mundialmente. No enten

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Tarsounas, Madalina Cecilia. "Synaptonemal complex proteins, post-translational modifications, protein-protein interactions and interaction with the rad51/dmc1 recombinases." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0007/NQ39313.pdf.

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Diogenes, Adriana de Holanda Mafaldo. "Capilaroscopia na DMTC: um processo dinâmico associado ao envolvimento intersticial pulmonar e à gravidade de doença." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5145/tde-22112006-093814/.

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Selecionamos consecutivamente 63 pacientes com doença mista do tecido conectivo (DMTC) (Kasukawa, 87) para determinar a relevância do padrão SD. Ter uma capilaroscopia periungueal (CPU) até cinco anos antes do início do estudo foi o principal critério de inclusão. Na entrada, avaliamos o envolvimento de órgãos e os auto-anticorpos. A idade média e o tempo de doença foram 45,3 + 10 e 8,45 + 5,42 anos, respectivamente. O padrão SD foi observado em 41 pacientes na entrada (65%) e em 45 na CPU prévia (71,5%), p = 0,20. Dez pacientes (16%) alteraram a CPU, 7 normalizaram e 3 desenvolveram padrão SD

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Rodgers, Edmund William. "Sexual Plasticity in a Marine Goby (Lythrypnus dalli): Social, Endocrine, and Genetic Influences on Functional Sex." Digital Archive @ GSU, 2007. http://digitalarchive.gsu.edu/biology_diss/34.

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Sex determination occurs early in development for most animals, at which time sex is fixed for life. Many teleost fishes, however, exhibit remarkable sexual plasticity throughout their life history, ranging from multiple morphs within a sex to functional adult sex reversal. To understand the development and evolution of adult sex reversal, I examined behavioral, endocrine, and genetic contributions to the regulation of functional sex in adult animals, using the bluebanded goby (Lythrypnus dalli) as an experimental model. This species was found to be equally capable of sexual transitions fro

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Nilsson, Kristian. "Film formation of latex in dry coating films." Thesis, Karlstad University, Faculty of Technology and Science, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-1048.

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<p>The objective of this master thesis was to investigate the possibility to measure the gain in stiffness of the dry coating due to film formation of latex with a Dynamic Mechanic Thermal Analyzer (DMTA). This could tell when and to which extent the latex forms a film after the drying process.</p><p>Two latices with different Tg was used for the experiments, one with a Tg of 36°C, denoted hard, and the one with a Tg of 8°C, denoted soft. The hard latex was used to make coating samples that would not form a film when dried at room temperature and the soft latex was used as a reference to the c

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Haridas, Nakul Raghavanand. "Parylene based low actuation MEMS phase shifters for reconfigurable antenna applications." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/17079.

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Wireless networks face ever-changing demands on their spectrum and infrastructure resources such as, increased communication bands, capacity-intensive data applications, and the steady growth of worldwide wireless subscribers. This rapid increase in the use of wireless communication and the dependence on a reliable connectivity leads manufacturers to seek systems which are ever smaller, low power, provide long range, and high bandwidth, whilst giving higher reliable technologies. In modern communication systems MEMS is now finding its way, replacing older more high power and non-linear systems

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Pightling, Arthur William. "The evolutionary history of meiotic genes: early origins by duplication and subsequent losses." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/2960.

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Meiosis is necessary for sexual reproduction in eukaryotes. Genetic recombination between non-sister homologous chromosomes is needed in most organisms for successful completion of the first meiotic division. Proteins that function during meiotic recombination have been studied extensively in model organisms. However, less is known about the evolution of these proteins, especially among protists. We searched the genomes of diverse eukaryotes, representing all currently recognized supergroups, for 26 genes encoding proteins

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Chmelíková, Jitka. "Stanovení exprese molekul transportu a metabolismu železa u vybraných chronických onemocnění." Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-295879.

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Iron is an essential element for human organism, because it cooperates as a cofactor of enzymes in many metabolic pathways. Iron is a component of hemoglobin, and thus it is indispensable for the oxygen transport to tissues. It can exist as a ferrous or ferric form. However, ferrous iron paticipates in reactions in which highly reactive hydroxyl group can be formed. This product is harmful for the organism. Non-heme iron is taken up to the circulation through duodenal enterocyte. Iron excretion is carried out only by desquamation of the enterocytes or by bleeding. Therefore, iron intake must b

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