Relevant bibliographies by topics / DMT1

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Academic literature on the topic 'DMT1'

Author: Grafiati
Published: 4 June 2021
Last updated: 27 April 2022

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Journal articles on the topic "DMT1"

1

Tabuchi, Mitsuaki, Naotaka Tanaka, Junko Nishida-Kitayama, Hiroshi Ohno, and Fumio Kishi. "Alternative Splicing Regulates the Subcellular Localization of Divalent Metal Transporter 1 Isoforms." Molecular Biology of the Cell 13, no. 12 (December 2002): 4371–87. http://dx.doi.org/10.1091/mbc.e02-03-0165.

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Divalent metal transporter 1 (DMT1) is responsible for dietary-iron absorption from apical plasma membrane in the duodenum and iron acquisition from the transferrin cycle endosomes in peripheral tissues. Two isoforms of the DMT1 transcript generated by alternative splicing of the 3′ exons have been identified in mouse, rat, and human. These isoforms can be distinguished by the different C-terminal amino acid sequences and by the presence (DMT1A) or absence (DMT1B) of an iron response element located in the 3′ untranslated region of the mRNA. However, it has been still unknown whether the structural differences between the two DMT1 isoforms is functionally important. Here, we report that each DMT1 isoform exhibits a differential cell type–specific expression patterns and distinct subcellular localizations. DMT1A is predominantly expressed by epithelial cell lines, whereas DMT1B is expressed by the blood cell lines. In HEp-2 cells, GFP-tagged DMT1A is localized in late endosomes and lysosomes, whereas GFP-tagged DMT1B is localized in early endosomes. Using site-directed mutagenesis, a Y555XLXX sequence in the cytoplasmic tail of DMT1B has been identified as an important signal sequence for the early endosomal-targeting of DMT1B. In polarized MDCK cells, GFP-tagged DMT1A and DMT1B are localized in the apical plasma membrane and their respective specific endosomes. Disruption of the N-glycosylation sites in each of the DMT1 isoforms affects their polarized distribution into the apical plasma membrane but not their correct endosomal localization. Our data indicate that the cell type–specific expression patterns and the distinct subcellular localizations of two DMT1 isoforms may be involved in the different iron acquisition steps from the subcellular membranes in various cell types.
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Rolim, Luiz Clemente, João Roberto de Sá, Antonio Roberto Chacra, and Sérgio Atala Dib. "Heterogeneidade clínica e coexistência das neuropatias diabéticas: diferenças e semelhanças entre diabetes melito tipos 1 e 2." Arquivos Brasileiros de Endocrinologia & Metabologia 53, no. 7 (October 2009): 818–24. http://dx.doi.org/10.1590/s0004-27302009000700005.

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OBJETIVO: Estudar a heterogeneidade e a coexistência das neuropatias no diabetes melito tipos 1 (DMT1) e 2 (DMT2). MÉTODOS: Foram avaliados 74 DMT2 e 20 DMT1 em relação à idade (anos), tempo de diagnóstico do DM (TDDM, em anos), índice de massa corpórea (IMC, kg/m²), HbA1c e tipo de neuropatia (critérios da American Diabetes Association). RESULTADOS: DMT1 era mais jovem (32,7 ± 11 versus 56,9 ± 10,3; p = 0,0001), com maior TDDM (17,1 ± 9,7 versus 10,4 ± 6,8; p = 0,003) e menor IMC (23,6 ± 3,8 versus 28,4 ± 5,3; p = 0,0005). A neuropatia autonômica cardiovascular (NAC) (60% versus 32,4%; p = 0,02) e a coexistência desta com polineuropatia (PND) (62,5% versus 33,3%; p = 0,03) foram mais prevalentes no DMT1; a PND dolorosa crônica (PNDDC) (60,8% versus 30,0%; p = 0,009) o foi no DMT2. A HbA1c (p = 0,04) foi preditiva de PND em ambos os grupos. O TDDM (p = 0,03) e a PNDDC (p = 0,003) foram preditivos de NAC no DMT1. A idade (p = 0,0004) teve valor preditivo para PNDDC no DMT2. CONCLUSÕES: As neuropatias apresentam distribuição heterogênea no DMT1 e no DMT2. Com exceção do controle glicêmico, os fatores relacionados a essa complicação diferem de acordo com o tipo de diabetes.
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Osorio-Concepción, Macario, Carlos Lax, Eusebio Navarro, Francisco E. Nicolás, and Victoriano Garre. "DNA Methylation on N6-Adenine Regulates the Hyphal Development during Dimorphism in the Early-Diverging Fungus Mucor lusitanicus." Journal of Fungi 7, no. 9 (September 8, 2021): 738. http://dx.doi.org/10.3390/jof7090738.

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The epigenetic modifications control the pathogenicity of human pathogenic fungi, which have been poorly studied in Mucorales, causative agents of mucormycosis. This order belongs to a group referred to as early-diverging fungi that are characterized by high levels of N6-methyldeoxy adenine (6mA) in their genome with dense 6mA clusters associated with actively expressed genes. AlkB enzymes can act as demethylases of 6mA in DNA, with the most remarkable eukaryotic examples being mammalian ALKBH1 and Caenorhabditis elegans NMAD-1. The Mucor lusitanicus (formerly M. circinelloides f. lusitanicus) genome contains one gene, dmt1, and two genes, dmt2 and dmt3, encoding proteins similar to C. elegans NMAD-1 and ALKBH1, respectively. The function of these three genes was analyzed by the generation of single and double deletion mutants for each gene. Multiple processes were studied in the mutants, but defects were only found in single and double deletion mutants for dmt1. In contrast to the wild-type strain, dmt1 mutants showed an increase in 6mA levels during the dimorphic transition, suggesting that 6mA is associated with dimorphism in M. lusitanicus. Furthermore, the spores of dmt1 mutants challenged with macrophages underwent a reduction in polar growth, suggesting that 6mA also has a role during the spore–macrophage interaction that could be important in the infection process.
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Ganeva, S., K. Todorova, Ts Lukanov, G. Rayanova, and S. Blajeva. "Levels of Lymphocyte Subpopulations in Peripheral Blood among Patients with Diabetes." Acta Medica Bulgarica 48, no. 1 (April 1, 2021): 75–80. http://dx.doi.org/10.2478/amb-2021-0012.

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Abstract The aim of the study was to investigate the lymphocyte (lymph) subpopulations in peripheral blood as a part of the immune response among patients with diabetes mellitus type 1 (DMT1) and diabetes mellitus type 2 (DMT2). Patients and methods: A prospective, cross-sectional, comparative, “case-control” study was conducted among 22 patients with DMT1 and 70 patients with DMT2. The levels of lymph subtypes [general nonspecific T-lymph (CD3+); T-helper lymph (CD4+); T-cytotoxic lymph (CD8+), natural killers [NK cells (CD3\ CD16+/CD56)] and B-lymph (CD19+)] in blood was measured and compared by flow-cytometric analisys (FAC Sort, BD). Results were compared to those of 21 healthy persons. The data was processed using the statistics software. Results: Patients with DMT1 had longer duration of the disease, compared to patients with DMT2. No significant differences between arterial blood pressure, НвА1с levels and lipid profile among the patients with DMT1 and DMT2 were present. There were no differences in the total leukocyte count between the groups (DMT1-6,91 ± 1,32.109/l; DMT2-7,28 ± 1,85.109/l; controls-6,89 ± 1,07.109/l). The results from the flowcytometric investigation showed significantly higher absolute number of T-all lymph (CD3+), Th lymph (CD4+) and all NK (CD3\ CD16+/CD56), as well as a lower absolute number of Ts (CD8+) and B (CD19+) lymph among the diabetic patients compared to healthy subjects. The Th/Ts ratio in patients with DMT1 (2,02 ± 0,44) and DMT2 (2,36 ± 0,37) was also significantly higher compared to ratio of controls (1,02 ± 0,06). No significant differences were noted in the lymph subpopulations between the two groups with DM. Conclusions: Changes of lymph types in peripheral blood in diabetic patients demonstrate immune activation and dysregulation among the two types of diabetes.
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Banks, Andrae, Lashawnda Fields, Curtis O’Dwyer, Marquisha Lawrence Scott, and Sean Joe. "Treating Mental Illness Among Diabetic Black Male Adolescents." Research on Social Work Practice 28, no. 3 (April 12, 2017): 330–39. http://dx.doi.org/10.1177/1049731517702746.

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Objective: To examine randomized controlled trials (RCTs) for treatment evidence for Black male adolescents suffering from comorbid mental illness and diabetes mellitus. Method: A review of the studies published in English-language journals was conducted. Results: We found no RCT focused on Black males with diabetes mellitus Type 2 (DMT2). However, we found RCT inclusive of Black male adolescents with diabetes mellitus Type 1 (DMT1). Multisystemic therapy appears to be the best supported overall treatment for DMT1 management and psychosocial functioning followed by an enhanced form of behavioral family systems therapy for diabetics. Metformin was the only treatment in this review noted for use within DMT2. Metformin and a nursing-based telephone case management intervention realized utility as secondary services. Conclusions: There are gaps present for what effectively treats comorbid mental illness and DMT2 in Black male adolescents. For comorbid mental illness and DMT1, there are gaps in additional efficacious treatments, effectiveness across conditions, and effect duration beyond 24 months.
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Cvetković, Tatjana, Predrag Vlahović, Vidosava đorđević, Lilika Zvezdanović, Dušica Pavlović, Gordana Kocić, and Dušan Sokolović. "The Significance of Urinary Markers in the Evaluation of Diabetic Nephropathy." Journal of Medical Biochemistry 27, no. 3 (July 1, 2008): 376–82. http://dx.doi.org/10.2478/v10011-008-0019-y.

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The Significance of Urinary Markers in the Evaluation of Diabetic Nephropathy Oxidative stress is considered to be a unifying link between diabetes mellitus (DM) and its complications, including nephropathy (DN). The aim of this study was to determine the parameters of oxidative injury of lipids and proteins as well as the activity of ectoenzymes in the urine of DN patients. The study included 40 individuals: 10 patients with type 2 diabetes mellitus and microalbuminuria (DMT2-MIA), 10 type 2 diabetic patients with macroalbuminuria (DMT2-MAA), 10 patients with type 1 diabetes and microalbuminuria (DMT1-MIA) and 10 age- and sex-matched healthy subjects (control). In the urine we determined TBA reactive substances (TBARS), reactive carbonyl groups (RCG), and the activity of ectoenzymes N-acetyl-β-d-glucosaminidase (NAG), plasma cell differentiation antigen (PC-1), aminopeptidase N (APN) and dipeptidyl peptidase IV (DPP IV). A higher concentration of TBARS in the urine was found in DMT2-MIA and DMT1-MIA, compared to the control group (p<0.001 and P<0.05). The urine concentration of RCD shows similar results with a significant elevation in the groups with DMT2-MAA and DMT1-MIA, compared to the DMT2-MIA (p<0.001) and control group (p<0.001). Activities of NAG, APN and DPPIV were significantly higher in the urine of DMT2-MAA, compared to the control (p<0.01). The activity of PC-1 was slightly increased in that group, but not significantly. In conclusion, the level of oxidative stress markers and activities of brush border ectoenzymes in the urine may be a useful non-invasive and easily repeatable test in DN.
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Hardianto, Dudi. "TELAAH KOMPREHENSIF DIABETES MELITUS: KLASIFIKASI, GEJALA, DIAGNOSIS, PENCEGAHAN, DAN PENGOBATAN." Jurnal Bioteknologi & Biosains Indonesia (JBBI) 7, no. 2 (January 14, 2021): 304–17. http://dx.doi.org/10.29122/jbbi.v7i2.4209.

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Diabetes mellitus is a metabolic disorder characterized by hyperglycemia. In general, diabetes is classified into type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), gestational, and other specific diabetes. The causes of diabetes are genetic disorders and environmental. Common symptoms of diabetes include: polydipsia, polyphagia, glycosuria, polyuria, dehydration, fatigue, weight loss, reduced vision, cramps, constipation, and candida infection. Test for diagnosis of diabetes include: fasting plasma glucose test, plasma glucose test after 2 hours of 75 g oral glucose administration, the glycated hemoglobin test (HbA1C), and random blood glucose test. Prevention of T1DM is still difficult because of the limited knowledge of metabolic, genetic, and immunological processes in the development of T1DM. T2DM is prevented by lifestyle and medical intervention. Insulin is the only drug for T1DM, whereas T2DM is treated with metformin as drug’s primary choice for reducing blood glucose levels. Diabetes melitus merupakan penyakit kelainan metabolisme yang ditandai dengan hiperglikemia. Secara umum, diabetes diklasifikasikan menjadi: diabetes melitus tipe 1 (DMT1), diabetes melitus tipe 2 (DMT2), gestasional, dan diabetes spesifik lain. Penyebab diabetes adalah kelainan genetik dan lingkungan. Gejala umum diabetes antara lain: polidipsia, polifagia, glikosuria, poliuria, dehidrasi, kelelahan, penurunan berat badan, daya penglihatan berkurang, kram, konstipasi, dan infeksi candida. Pemeriksaaan untuk diagnosis diabetes meliputi: pemeriksaan glukosa plasma saat puasa, pemeriksaan glukosa plasma setelah 2 jam pemberian glukosa oral 75 g, pemeriksaan hemoglobin terglikasi (HbA1C), dan pemeriksaan glukosa darah acak. Pencegahan DMT1 masih sulit karena terbatasnya pengetahuan proses metabolisme, genetik, dan imunologi pada perkembangan DMT1. DMT2 dicegah dengan intervensi gaya hidup dan intervensi medis. Insulin merupakan satu-satunya obat untuk DMT1, sedangkan DMT2 diobati dengan metformin sebagai pilihan utama dan non obat untuk menurunkan kadar glukosa dalam darah.
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Gunshin, Hiromi, Yuko Fujiwara, Angel O. Custodio, Cristina DiRenzo, Sylvie Robine, and Nancy C. Andrews. "Iron Metabolism in the Mice with Targeted Mutations of the DMT1 Gene ." Blood 104, no. 11 (November 16, 2004): 50. http://dx.doi.org/10.1182/blood.v104.11.50.50.

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Abstract Divalent metal transporter 1 (DMT1) was shown to be important for iron metabolism through studies of the mk/mk mouse, which carries a spontaneous mutation (G185R) resulting in defective intestinal iron absorption and anemia. To further investigate the importance of this transporter in vivo, we inactivated the DMT1 gene through targeted deletion of transmembrane domains 3, 4 and 5. We obtained mice carrying a universally inactivated DMT1 allele (DMT1−/−) and mice carrying a floxed DMT1 allele that could be selectively inactivated by breeding to mice expressing a Cre recombinase transgene. We crossed the floxed mice to mice expressing Cre under the control of the Villin promoter to inactivate DMT1 exclusively in the intestine. All mutations were made on a 129S6/SvEvTac background. For comparison, we backcrossed the mk mutation onto the same background. We noted that, in this context, the mk/mk phenotype was much less severe. DMT1−/− mice were born with substantial liver iron stores, indicating that fetal DMT1 is not required for placental iron transfer or hepatic iron loading. However, DMT1−/− mice invariably died of anemia by day 7, suggesting that DMT1 is important for erythroid iron acquisition but not absolutely required. Transfusions improved survival. The DMT1−/− phenotype was much more severe than the mk/mk phenotype, and compound heterozygous DMT1-/mk mice survived to adulthood. These results confirm that the mk mutation does not result in total loss of protein function. Intestine-specific inactivation of DMT1 caused no abnormalities at birth, but progressive anemia developed thereafter. At 12 weeks, mice lacking intestinal DMT1 were more anemic than mk/mk mice. To investigate the importance of DMT1 in hematopoietic cells, we transferred fetal liver hematopoietic stem cells (HSC) from DMT1−/− animals to irradiated wild type adult mice. Twelve weeks after transfer, DMT1−/− HSC recipients were anemic, but less so than singly transfused DMT1−/− mice or mice lacking intestinal DMT1. DMT1−/− HSC recipients accumulated more liver iron than wild type HSC recipients, suggesting a compensatory increase in intestinal iron absorption and/or altered iron distribution. Surprisingly, though DMT1−/− mice died as neonates, heterozygosity for a null Hfe mutation allowed some DMT1−/−;Hfe+/−animals to survive without transfusions. The effect was more pronounced in animals homozygous for Hfe null mutations. We took advantage of this to compare untransfused DMT1−/− mice with mk/mk mice on an Hfe−/− background. Liver iron content and hemoglobin levels of both mk/mk;Hfe−/− and DMT1−/−;Hfe−/− mice were significantly lower than DMT1+/+;Hfe−/− mice, as expected. Again, mk/mk mice were less severely affected than DMT1−/− mice. We have confirmed that DMT1 plays primary roles in intestinal iron absorption and erythroid iron acquisition but it is likely that there are minor, alternative iron uptake mechanisms. The mk mutation allows for considerable residual iron transport activity. Inactivation of Hfe ameliorates the effects of DMT1 deficiency through an as yet unknown mechanism.
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Yeh, Kwo-Yih, Mary Yeh, J. Abra Watkins, Juan Rodriguez-Paris, and Jonathan Glass. "Dietary iron induces rapid changes in rat intestinal divalent metal transporter expression." American Journal of Physiology-Gastrointestinal and Liver Physiology 279, no. 5 (November 1, 2000): G1070—G1079. http://dx.doi.org/10.1152/ajpgi.2000.279.5.g1070.

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The divalent metal transporter (DMT1, also known as NRAMP2 or DCT1) is the likely target for regulation of intestinal iron absorption by iron stores. We investigated changes in intestinal DMT1 expression after a bolus of dietary iron in iron-deficient Belgrade rats homozygous for the DMT1 G185R mutation (b/b) and phenotypically normal heterozygous littermates (+/b). Immunofluorescent staining with anti-DMT1 antisera showed that DMT1 was located in the brush-border membrane. Duodenal DMT1 mRNA and protein levels were six- and twofold higher, respectively, in b/b rats than in +/b rats. At 1.5 h after dietary iron intake in +/b and b/b rats, DMT1 was internalized into cytoplasmic vesicles. At 1.5 and 3 h after iron intake in +/b and b/b rats, there was a rapid decrease of DMT1 mRNA and a transient increase of DMT1 protein. The decrease of DMT1 mRNA was specific, because ferritin mRNA was unchanged. After iron intake, an increase in ferritin protein and decrease in iron-regulatory protein binding activity occurred, reflecting elevated intracellular iron pools. Thus intestinal DMT1 rapidly responds to dietary iron in both +/b and b/b rats. The internalization of DMT1 may be an acute regulatory mechanism to limit iron uptake. In addition, the results suggest that in the Belgrade rat DMT1 with the G185R mutation is not an absolute block to iron.
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Okazaki, Yasumasa, Yuxiang Ma, Mary Yeh, Hong Yin, Zhen Li, Kwo-yih Yeh, and Jonathan Glass. "DMT1 (IRE) expression in intestinal and erythroid cells is regulated by peripheral benzodiazepine receptor-associated protein 7." American Journal of Physiology-Gastrointestinal and Liver Physiology 302, no. 10 (May 15, 2012): G1180—G1190. http://dx.doi.org/10.1152/ajpgi.00545.2010.

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The divalent metal transporter 1 (DMT1) is essential for cellular uptake of iron, mediating iron absorption across the duodenal brush border membrane. We have previously shown that with iron feeding DMT1 in the brush border membrane undergoes endocytosis into the subapical compartment of enterocytes. To understand the mechanisms of iron-induced endocytosis of DMT1, we used the yeast two-hybrid system to find proteins that interact with DMT1 and isolated from a rat duodenal cDNA library a protein that interacts specifically with the IRE containing isoform of DMT1 {DMT1 [iron-responsive element (IRE)]}. The protein (Genbank AY336075 ) is 97.5% identical with peripheral benzodiazepine receptor-associated protein 7 (PAP7), a protein that interacts with the peripheral benzodiazepine receptor. PAP7 is ubiquitously expressed in the rat and in multiple cell lines with consensus sequences including a nuclear localization signal and a Golgi dynamic domain. PAP7, expressed on the brush border of rat duodenum, copurified with DMT1 in brush border membrane vesicles, and following iron feeding, was internalized in parallel with the internalization of DMT1. To determine if PAP7 plays a role in cellular iron metabolism, we downregulated PAP7 expression in K562 cells with small interfering RNA. Following the decrease in PAP7 protein, DMT1 (IRE) protein but not mRNA was significantly downregulated but without effect on DMT1 (non-IRE), transferin (Tf)R1, or ferritin expression. Lowered levels of PAP7 resulted also in decreased cell proliferation and G1cell cycle arrest. These data are consistent with PAP7 interacting with DMT1 (IRE) and regulating DMT1 (IRE) expression in K562 cells by modulating expression of DMT1 (IRE) protein.
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Dissertations / Theses on the topic "DMT1"

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Tchernitchko, Dimitri. "Études moléculaires de DMT1, un transporteur membranaire du fer." Paris 7, 2002. http://www.theses.fr/2002PA077183.

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Rivas, Romero Daniela Paz. "Modelación molecular y estudio de la isoforma 1A/IRE(+) de la proteína DMT1 humana." Tesis, Universidad de Chile, 2015. http://repositorio.uchile.cl/handle/2250/137489.

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Ingeniera Civil en Biotecnología
En distintos estudios se ha determinado que mutaciones en la proteína transportadora DMT1, encargada de transportar hierro desde el lumen intestinal hacia los enterocitos, son causantes de distintos tipos de anemia, no obstante, poco se conoce sobre su estructura tridimensional y su mecanismo de transporte. Por esta razón, el objetivo del presente trabajo es obtener un modelo estructural de la isoforma 1A/IRE(+) de la proteína DMT1 humana y a partir de éste estudiar el posible comportamiento de la proteína inserta en membrana. La predicción de dominios transmembrana para la proteína de interés estableció la presencia de 12 dominios transmembrana, 6 loops extracelulares, 5 loops intracelulares y los extremos amino y carboxilo terminales al interior del citoplasma de los enterocitos, lo cual concuerda totalmente con lo expuesto en bibliografía. Se obtuvieron 100 modelos de la proteína mediante modelamiento comparativo, utilizando el cristal de la familia de la proteína, ScaDMT, como plantilla principal. El mejor modelo se obtuvo a través de un análisis energético y estructural. Este modelo obtuvo un z-score de -4.3, dentro de la densidad de puntajes obtenidos por estructuras cristalinas, un perfil energético por residuo similar al del cristal de ScaDMT, y un gráfico de Ramachandran con tan solo 2 residuos dentro de zonas no permitidas. Se realizaron cuatro dinámicas moleculares para estudiar el comportamiento del modelo en membrana, las cuales fueron analizadas para estudiar las características de la proteína. A partir del análisis de los modos normales, se observó un movimiento de apertura y cierre, el cual podría representar el movimiento principal de captura y liberación del ion de hierro. Por otro lado, se presentó una variación en el potencial electrostático en las regiones superior e inferior de la proteína, lo que podría estar relacionado al mecanismo de interacción de la proteína con hierro. A partir del análisis del comportamiento de las moléculas de agua en el sistema, se determinó que éstas ingresan a la proteína por la zona orientada hacia el citoplasma, posicionándose entre las hélices TM1 y TM6, donde se ubica el ion de hierro. Finalmente, en cuanto a la interacción de la proteína con hierro, se proponen los residuos Asp115, Asn118, Ala291 y Met294 como principales candidatos a interaccionar con él, y se observa un posible rol del agua en la estabilización de éste. De esta manera, los resultados y discusiones aquí expuestos representan los primeros avances para un mejor conocimiento de la estructura y características de la proteína DMT1 humana. Se requiere profundizar y extender estos análisis para poder establecer bases más sólidas respecto a la relación estructura-función y dilucidar el mecanismo de transporte asociado a la proteína. Esto resultaría de gran utilidad para comprender la causa de las enfermedades asociadas a mutaciones en DMT1 y posteriormente proponer tratamientos más efectivos para estas enfermedades.
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Colins, Rodríguez Andrea Justina. "Determinación experimental y modelación matemática de los flujos de transporte de hierro en células Caco-2." Tesis, Universidad de Chile, 2015. http://repositorio.uchile.cl/handle/2250/135289.

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Magíster en Ciencias de la Ingeniería, Mención Química
Ingeniera Civil en Biotecnología
El hierro es un metal traza, fundamental para la existencia de la vida. Los niveles de hierro en el organismo deben ser altamente controlados ya que pequeñas variaciones desencadenan numerosas enfermedades, entre ellas la anemia y hemocromatosis. En seres humanos la presencia de este metal se controla regulando su absorción intestinal, en donde el hierro ingresa al organismo a través de la proteína DMT1, ubicada en la cara apical de los enterocitos. Luego, el hierro es transportado a la cara basolateral y finalmente, es expulsado al torrente sanguíneo mediante la proteína FPN1. \par El objetivo de este trabajo es analizar el transporte de hierro en células Caco-2 mediante métodos experimentales y modelación matemática. Para esto se determinaron experimentalmente los flujos de hierro en el tiempo, a diferentes concentraciones iniciales en el medio apical. Se determinó la velocidad inicial de la absorción en función de la concentración apical. Y además, se midió la cantidad de hierro que ingresa a las células luego de una segunda exposición al metal. Los resultados de estos experimentos concuerdan con las magnitudes reportadas en casos similares, pero muestran un comportamiento no lineal en los flujos de absorción, lo cual no había sido observado anteriormente. \par Para analizar matemáticamente los resultados experimentales obtenidos, se desarrolló un modelo empírico y un modelo fenomenológico. El modelo empírico se construyó utilizando un algoritmo de programación genética modificado para lograr mejores resultados. El modelo representa adecuadamente los datos experimentales utilizados en la etapa de entrenamiento, alcanzado un coeficiente de determinación de $R^2=0.85$ y un error de generalización de $MSE_{jk}=1.32$. Además, el modelo permite representar la velocidad inicial de absorción apical, es decir, datos que no fueron empleados en la etapa de entrenamiento del algoritmo. Por otro lado, el modelo exhibe características básicas del fenómeno, sin que se le entregue información a priori al respecto. \par El modelo fenomenológico consta de un conjunto de ecuaciones diferenciales ordinarias que capturan dos fenómenos relevantes. La actividad de DMT1 y la variación de la cantidad de ésta en la membrana apical. Este modelo permite simular todos los escenarios estudiados experimentalmente, asimismo representa los flujos de absorción apical con un coeficiente de determinación de $R^2=0.867$, mientras que su error de generalización es de $MSE_{jk}=1.39$. \par Del análisis realizado, se concluye que la endocitosis de DMT1 desde la cara apical, es un fenómeno relevante en el proceso de absorción de hierro. Este fenómeno no había sido considerado anteriormente y debe ser estudiado en detalle para poder caracterizar el sistema. \par En el trabajo se planteó una metodología para desarrollar modelos empíricos que puede utilizarse en otros sistemas biológicos complejos. Su principal ventaja es que permite mejorar la capacidad de generalización de los modelos realizados.
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Sáez, Rojas Carla. "Modelamiento matemático del movimiento de transportadores de hierro en células caco-2." Tesis, Universidad de Chile, 2014. http://www.repositorio.uchile.cl/handle/2250/130324.

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Ingeniera Civil en Biotecnología
El hierro es un elemento fundamental para muchos organismos por las reacciones en las que se encuentra involucrado, y su absorción está altamente regulada por mecanismos a diferentes niveles. El transporte de hierro se realiza en el duodeno a través de proteínas transportadoras que se encuentran en la membrana apical de los enterocitos (DMT1, Divalent Metal Transporter 1). Uno de los mecanismos de regulación involucra la traslocación de estas proteínas hacia el interior de las células cuando éstas son expuestas a una cierta concentración de hierro en la cara apical. Mediante este mecanismo se disminuye la absorción del mineral minutos después de dicha exposición. En el presente trabajo se busca proponer un modelo fenomenológico que permita representar cualitativamente los perfiles de distribución espacial de DMT1 en el interior célular. Estos perfiles han sido observados experimentalmente en la línea celular Caco-2, la cual es comúnmente utilizada para estudios de transporte de hierro debido a sus características similares con los enterocitos del intestino delgado. El modelo propuesto consiste en un sistema de ecuaciones diferenciales parciales cuya simulación permite obtener la distribución de DMT1 en el tiempo y espacio. Se realizaron simulaciones para obtener la distribución estacionaria inicial, y la evolución del sistema desde dicho estado hasta alcanzar una nueva distribución estacionaria producto de perturbar el sistema mediante la introducción de un pulso de hierro. Como resultado se observó que el modelo es capaz de reproducir cualitativamente el comportamiento observado experimentalmente. A través de un estudio de variación de parámetros, se verificó que el comportamiento del sistema corresponde a lo esperado biológicamente. A partir de dicho estudio se encontró un set de parámetros que permiten simular el comportamiento en el estado previo a la exposición de hierro y uno que simula el estado posterior a dicha exposición. Se concluye que este modelo propuesto representa una primera aproximación para la simulación del movimiento de DMT1 en células Caco-2. El modelo desarrollado en este trabajo es adecuado también para la representación de otros sistemas que involucren movimiento de vesículas o elementos desde un sitio a otro de la célula, debido a que sus ecuaciones son generales y sus parámetros pueden ser variados para la simulación de diferentes escenarios tales como distintas concentraciones de proteínas motoras o distintas velocidades de transporte. Ejemplos de estos sistemas son el movimiento vesículas de las proteínas transportadoras de glucosa GLUT-4, o la transistosis de diversos elementos en células epiteliales.
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Shawki, Ali. "The Functional Properties and Intestinal Role of the H+-Coupled Divalent Metal-Ion Transporter 1, DMT1." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1448037106.

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Salazar, Rivera Julio. "Altération du métabolisme du fer dans la maladie de Parkinson : participation du Transporteur 1 de Métaux Divalents (DMT1) et des Protéines Régulatrices du Fer (IRPs) dans la mort des neurones dopaminergiques de la Substantia Nigra Pars Compacta." Paris 6, 2008. http://www.theses.fr/2008PA066242.

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La maladie de Parkinson (MP) est caractérisée par la mort préférentielle et accélérée des neurones dopaminergiques de la substance noire (SN) dont la cause est inconnue. De nombreuses études ont montré une augmentation des taux de fer dans les neurones dopaminergiques mélanisés et dans les cellules gliales de cette structure. En raison de son rôle pro-oxidant, le fer pourrait être un des facteurs expliquant la mort massive des neurones dopaminergiques dans la MP. Des études post-mortem, réalisées au sein de notre laboratoire (INSERM UMR679), ont montré que les sites de liaison de la transferrine, impliqués dans une voie classique d’entrée du fer, sont diminués en numéro dans les neurones dopaminergiques de sujets parkinsoniens. Avec l’objectif d’identifier le mécanisme d’augmentation du fer dans la MP, nous avons étudié la participation d’un autre transporteur : le transporteur 1 des métaux divalents (DMT1). Nos expériences ont montré que DMT1 est exprimé préférentiellement par les neurones dopaminergiques dans la SN des humains et des rongeurs. D’autre part, le niveau d’expression d’une des isoformes de DMT1 (DMT1+IRE) est augmenté dans des modèles animaux de la MP et dans la SN de cerveaux parkinsoniens. Et enfin, des rongeurs portant une mutation dans le gène DMT1 (les souris microcytiques et les rats Belgrade) sont protégés contre les neurotoxines MPTP et 6-OHDA, utilisées comme modèles animaux de la MP. Ces observations soutiennent l’hypothèse d’un rôle de DMT1 dans l’accumulation de fer et la mort neuronale dans la MP. Par la suite, nous nous sommes focalisés à étudier la potentielle participation des protéines régulatrices du fer (IRPs) dans la neurodegeneration associée à la MP. Les IRPs contrôlent la traduction de messagers des protéines du métabolisme du fer, comme DMT1. Normalement impliquées dans homéostasie cellulaire du fer, elles peuvent être modulées par le stress oxydant et favoriser l’augmentation du fer. En cohérence avec cette hypothèse nous avons montré que la souris déficiente pour le gène IRP1 est protégée contre la toxicité du MPTP. Cette étude confirme le rôle du fer dans la neurodégénérescence associée à la MP et suggère la participation de DMT1 et IRP1 dans la neurotoxicité médiée par le fer.
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Thomas, Carla. "The validation and use of the rat intestinal epithelial cell line 6 (IEC-6) to study the role of ferroportin1 and divalent metal transporter 1 in the uptake of iron from Fe(II) and Fe(III)." University of Western Australia. Physiology Discipline Group, 2003. http://theses.library.uwa.edu.au/adt-WU2004.0019.

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[Formulae and special characters can only be approximated here. Please see the pdf version of the abstract for an accurate reproduction.] Iron is vital for almost all living organisms by participating in a wide variety of metabolic processes, including oxygen transport, DNA synthesis, and electron transport. However, iron concentrations in body tissues must be tightly regulated because excessive iron leads to tissue damage, as a result of formation of free radicals. In mammals since no controlled means of eliminating unwanted iron has evolved, body iron balance is maintained by alterations in dietary iron intake. This occurs in the duodenum where most dietary iron is absorbed. Absorption involves at least two steps, uptake of iron from the intestinal lumen and then its transport into the body, processes that occur at the apical and basal membranes of enterocytes, respectively. In chapter one of this thesis the background information relevant to iron absorption is described. Despite numerous studies, the role of these proteins in iron absorption remains unclear, partly because many studies have reported them in non-enterocyte cell lines where the expression of the proteins involved in iron absorption is unlikely and therefore the physiological significance of the findings uncertain. Therefore, the study of iron absorption would value from additional cell lines of intestinal origin being used, preferably derived from a species used to comprehensively study this process in vivo, namely the rat. Validation of such a model would enable comparisons to be made from a molecular level to its relevance in the whole organism. In chapter 3 of this thesis, the rat intestinal cell line 6 (IEC-6) was examined as a model of intestinal iron transport. IEC-6 cells expressed many of the proteins involved in iron absorption, but not the ferrireductase Dcytb, sucrase or αvβ3 integrin. In addition, in IEC-6 cells the expression of the apical transporter divalent metal transporter 1 (DMT1), the iron storage protein ferritin, the uptake of Fe(II) and Fe(III) were regulated by cellular iron stores as is seen in vivo. This suggests that IEC-6 cells are of a lower villus enterocyte phenotype. Presented in chapter 4 is the study of the uptake of iron from Fe(II):ascorbate and Fe(III):citrate by IEC-6 cells in the presence of a blocking antibody to the putative basolateral transporter ferroportin1 and of colchicine and vinblastine, different pHs, and over-expression of DMT1. It was shown that optimal Fe(II) uptake required a low extracellular pH and was dependent on DMT1. Uptake of Fe(III) functioned optimally at a neutral pH, did not require surface ferrireduction, and was increased during over-expression of DMT1. These observations suggest that intravesicular ferrireduction takes place before transport of Fe(II) to the cytoplasm by DMT1. This pathway was not blocked by a functional antibody against αvβ3 integrin but was inhibited by competition with unlabeled iron citrate or citrate alone. Surprisingly, a functional antibody against ferroportin1 had no effect on efflux but significantly reduced (p<0.05) uptake of Fe(II) by 40-50% and Fe(III) by 90%, indicating two separate pathways for the uptake of iron from Fe(II)-ascorbate and from Fe(III)-citrate in IEC-6 cells. Presented in chapter 5 is the development and validation of a technique for the removal of freshly isolated enterocytes from the rat duodenum and their use to study iron transport processes that enabled comparisons to be made between these cells, IEC-6 cells and the human enterocyte cell line Caco-2 cells. In chapter 6 a blocking antibody to ferroportin1 was shown to inhibit uptake of Fe(II) but not release of iron in freshly isolated duodenal enterocytes from rats and Caco-2 cells supporting the findings obtained with IEC-6 cells described in chapter 4. Fe(II) uptake was reduced only when the antibody was in contact with the apical membrane indicating its expression at the microvillus membrane. Confirming this, ferroportin1 was shown along the microvillus membrane of Caco-2 cells, in enriched microvillus membrane preparations and in enterocytes of duodenum tissue of rats where it co-localised with lactase. The significant findings to emerge from this thesis are that the IEC-6 cell is a valid model to study iron absorption producing results consistent with those found in freshly isolated enterocytes and in human enterocyte-like cells. In particular, ferroportin1 functions in the uptake of iron at the apical membrane possibly by modulating surface binding of Fe(II) to DMT1 or the activity of DMT1. In addition to this in Fe(II) uptake from Fe(III) ferroportin1 may also affect the number of Fe(III): citrate binding sites. Preliminary studies further characterizing the function of ferroportin1 at the apical membrane and at intracellular sites of IEC-6 cells along with integration of these data are discussed in chapter 7.
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Kirui, Joseph Kiprono. "ESR study of DMTM(TCNQ)₂." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/29191.

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The ESR g-value and susceptibility measurements for DMTM(TCNQ)₂ have been studied as a function of angle made by crystal with magnetic field and temperature. The angular dependence of g-value is fitted to g² = α+βcos2θ - γsin2θ for three orthogonal directions of crystal rotation. The principal g-values are close to those expected for TCNQ compounds: g₁ = 2.0034, g₂ = 2.0030, g₃ = 2.0024. The susceptibility as a function of temperature agrees with bulk susceptibility measurements except that the maximum position occurs at about 30 K. The results of Oostra et al. for bulk susceptibility showed a maximum at around 50 K. The phase transition reported by Visser et al. at 272 K is observed in the ESR data as a 15% decrease in susceptibility. The linewidth is remarkably anisotropic typical of TCNQ salts. The phase transition study is done for two orientations of the crystal with the magnet field. In one of the orientations the linewidth narrows from 0.15 to 0.11 gauss and in the other it narrows from 0.24 to 0.18 gauss. In the former case there is a growth of a second line due to the twinned stack; transformation twinning takes place at the phase transition. A small level-crossing interaction is inferred from the change in relative intensities of the lines near the crossover.
Science, Faculty of
Physics and Astronomy, Department of
Graduate
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9

Gomes, Carolina Pereira. "Reprodução em Characidium schubarti (Teleostei: Characiformes): análise da reprodução em cativeiro e de genes relacionados à diferenciação sexual (dmrt1, cyp19a1a e amh)." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/41/41131/tde-29052014-103655/.

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Os peixes teleósteos representam cerca de metade de todas as espécies de vertebrados já descritas. Esta rica diversidade reflete-se nas diferentes formas de determinação sexual, sendo as principais desencadeadas por influência ambiental e por fatores genéticos. Os genes envolvidos neste mecanismo têm sido caracterizados em diversas espécies de peixes teleósteos, como é o caso dos genes dmrt1 e amh que têm importante papel na diferenciação em machos de teleósteos e o gene cyp19a1a, que possui relação com a diferenciação sexual de fêmeas. Têm sido cada vez mais corrente na literatura, estudos envolvendo genes da via de diferenciação sexual em espécies de teleósteos, porém escassas são as informações em relação à ordem Characiformes. Além da genética, a biologia reprodutiva de peixes teleósteos engloba ainda estudos relativos ao papel dos hormônios e do ambiente na reprodução, inclusive na reprodução em cativeiro. A presente dissertação tem como principal objetivo a análise dos genes acima citados na espécie Characidium schubarti (Characiformes) - que possui pouca informação sobre sua biologia reprodutiva na literatura-; caracterizando fragmentos dos genes dmrt1 e cyp19a1a e a similaridade destes com os mesmos já descritos em outras ordens de peixes teleósteos. Além disso, foi possível no desenvolver do projeto, obter informações pertinentes em relação ao papel do ambiente e de hormônios exógenos na reprodução da espécie. Espera-se que com o aumento de pesquisas envolvendo genes relacionados ao sexo, o objetivo de controlar o gênero sexual em peixes economicamente importantes possa ser alcançado com sucesso a partir do controle da expressão de fatores da via de diferenciação
Teleost fishes represent about half of all vertebrate species already described. Such a rich diversity is reflected in different forms of sex determination, the main ones being triggered by environmental influences and genetic factors. Genes such as amh and dmrt1 are involved in this mechanism and have been characterized in several teleost fish species, they play an important role in the differentiation of teleost males whereas the cyp19a1a gene is related to the female sexual differentiation. Have been increasingly common in the literature, studies concerning the rule of genes in sex differentiation in teleosts, however pieces of information regarding the order Characiformes are scarce. Besides genetics, reproductive biology of teleost fishes also includes studies on the role of hormones and environment on reproduction, and also captive breeding. This thesis aims to analyze the aforementioned species in Characidium schubarti (Characiformes) genes for which little information exists on their reproductive biology literature featuring fragments of genes dmrt1 and cyp19a1a and the similarity of these with those already described in other orders of teleost fish . Moreover, it was possible to develop the project, obtaining relevant information regarding the role of the environment and exogenous hormones in reproduction of the species. It is expected that with the increase of research involving genes related to sex, in order to control the sexual gender for such an economically important fish can be successfully achieved from the control of the expression of factors of differentiation
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Xu, Yang. "Equalization algorithms for ADSL DMT system." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0004/MQ36756.pdf.

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Books on the topic "DMT1"

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1962-, Burnham Clint, Szewczyk Monika, Pakasaar Helga, and Presentation House Gallery, eds. Jeremy Shaw: DMT. North Vancouver, B.C: Presentation House Gallery, 2004.

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Lin, Yuan-Pei. Filter bank transceivers for OFDM and DMT systems. Cambridge: Cambridge University Press, 2011.

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Printing, London College of. Time calibration: Report for postgraduate diploma in DMT 1986. London: LCP, 1986.

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Tryptamine palace: 5-MeO-DMT and the Sonoran Desert Toad. Rochester, Vt: Park Street Press, 2009.

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Printing, London College of. Investigation of Logotype design: Report for Postgraduate diploma in DMT 1986. London: LCP, 1986.

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Strassman, Rick. DMT, la molécule de l'esprit: Les potentialités insoupçonnées du cerveau humain. Chambéry: Éd. Exergue, 2005.

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Printing, London College of. Computer generated airwork for flexography: Report for postgraduate diploma in DMT 1968. London: LCP, 1986.

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Printing, London College of. Facets: A fashion magazine for India : report for postgraduate diploma in DMT 1986. London: LCP, 1986.

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Printing, London College of. Variations: From Purcell to Pixels music printing and digital typography : report for postgraduate diplomain DMT 1986. London: LCP, 1986.

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Robb, Jessica F., and Lawrence M. Samkoff. Immunomodulatory Agents for Relapsing-Remitting Multiple Sclerosis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199341016.003.0025.

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The treatment of multiple sclerosis has become much more complicated with the development of new oral and other disease-modifying therapies (DMT) that have been added to the formulary of older injectables and natalizumab. To date, twelve medications have been approved in the United States for use in cases of relapsing multiple sclerosis. Neurologists managing patients with multiple sclerosis must integrate numerous variables when selecting the appropriate agent for each individual. This chapter presents an overview of the DMTs currently approved by the U.S. Food and Drug Administration for multiple sclerosis and suggests a therapeutic algorithm to aid in choosing among these medications.
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Book chapters on the topic "DMT1"

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Garrick, Michael D., and Laura M. Garrick. "Divalent metal transporter DMT1 (SLC11A2)." In Membrane Transporter Diseases, 107–22. Boston, MA: Springer US, 2003. http://dx.doi.org/10.1007/978-1-4419-9023-5_7.

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Reddy, P. Anantha, Anita H. Lewin, and Peter W. Schiller. "Synthesis and Pharmacological Evaluation of Highly Potent [Dmt1]DALDA Analogs." In Advances in Experimental Medicine and Biology, 473–74. New York, NY: Springer New York, 2009. http://dx.doi.org/10.1007/978-0-387-73657-0_203.

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Gaudiani, Jennifer L. "Type 1 Diabetes Mellitus and Concurrent Eating Disorders (ED-DMT1)." In Sick Enough, 175–83. New York, NY : Routledge, 2019.: Routledge, 2018. http://dx.doi.org/10.4324/9781351184731-19.

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Simola, Nicola, Micaela Morelli, Tooru Mizuno, Suzanne H. Mitchell, Harriet de Wit, H. Valerie Curran, Celia J. A. Morgan, et al. "DMTS." In Encyclopedia of Psychopharmacology, 416. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_4207.

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Metze, Dieter, Tam Nguyen, Birgit Haack, Alexander K. C. Leung, Noriko Miyake, Naomichi Matsumoto, A. J. Larner, et al. "DM1." In Encyclopedia of Molecular Mechanisms of Disease, 540. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_6377.

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Gooch, Jan W. "DMT." In Encyclopedic Dictionary of Polymers, 238. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_3896.

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Pfletschinger, Stephan. "DMT Modulation." In Handbook of Computer Networks, 473–91. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118256053.ch31.

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Mazin, Alexander V., and Olga M. Mazina. "Rad51 and Dmc1 Recombinases." In Molecular Life Sciences, 1009–16. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4614-1531-2_67.

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Mazin, Alexander V., and Olga M. Mazina. "Rad51 and Dmc1 Recombinases." In Molecular Life Sciences, 1–8. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4614-6436-5_67-2.

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Lutenegger, Alan J. "Dilatometer Test (DMT)." In In Situ Testing Methods in Geotechnical Engineering, 195–253. First edition. | Boca Raton, FL : CRC Press, 2021.: CRC Press, 2021. http://dx.doi.org/10.1201/9781003002017-6.

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Conference papers on the topic "DMT1"

1

Borges, Shirley Aparecida Azevedo, Ieda Carla Candido, Jaqueline Carvalho Rinaldi, and Joice Toracci Alves. "O DIABETES MELLITUS TIPO-I ALTERA A MORFOLOGIA DE GLÂNDULAS SALIVARES." In II Congresso Brasileiro de Saúde On-line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/1428.

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Introdução: A diabetes mellitus tipo 1 (DMT1) é uma doença metabólica, caracterizada pela destruição das células beta pancreáticas, levando a hiperglicemia crônica. Nas glândulas salivares pode provocar danos teciduais e prejuízo na produção de saliva. Objetivo: Este estudo tem como objetivo investigar se o DM1 altera a morfologia das glândulas salivares parótida e sublingual e submandibular. Materiais e métodos: Foram distribuídos 12 ratos Wistar adultos (250g) nos grupos: controle ou NG (normoglicêmico, n=6) e diabético ou DM1 (n=6). O DM1 foi induzido por injeção endovenosa de estreptozootocina (55 mg/kg de peso corporal) sendo considerados diabéticos os animais com glicemia de jejum e pós-prandial ≥ 300 mg/dL. Os animais foram eutanasiados 30 dias após a indução. As glândulas salivares foram dissecadas, pesadas, desidratadas em etanol, diafanizadas em xilol e emblocadas em parafina. Cortes de 5um foram corados em hematoxilina e eosina para análise histopatológica. O método de Weibel foi utilizado para analisar a proporção entre os compartimentos glandulares. Os dados foram submetidos a análise estatística pelo teste t e foi considerado significativo valores de p<0,05. Resultado: Dentre os principais resultados encontrados, pode-se listar a perda de polaridade das células epiteliais, vacuolização celular e diferença de distribuição entre os compartimentos glandulares. Conclusão: Conclui-se que o DM-1 alterou a morfológicas dos acinos e ductos das glândulas salivares.
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Barra, Jonathan, Iram Nelson, Lauren Elder, Ling Wang, and Margarida M. Barroso. "Abstract 2396: Role of iron transporter DMT1 in endosome-mitochondria interactions and mitochondrial metabolism in breast cancer cells." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-2396.

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Miranda, Fernanda Barros de. "PRINCIPAIS MÉTODOS PARA O DIAGNÓSTICO LABORATORIAL DO DIABETES MELLITUS TIPO 2." In II Congresso Brasileiro de Saúde On-line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/1429.

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Introdução: Diabetes Mellitus tipo 2 (DMT2) é uma doença por decorrência de resistência a insulina nas células musculares e adiposas devido à redução de sua ação, resultando em hiperinsulinismo e hiperglicemia. O DMT2 é o mais prevalente, corresponde de 90% a 95% dos casos e acomete em sua maioria, indivíduos adultos. Dados da Sociedade Brasileira de Diabetes mostram que o número de casos do DMT2 eleva a cada ano, em consequências de numerosas condições que influenciam sua etiologia, como fator genético, obesidade, sedentarismo, crescimento e envelhecimento populacional, tabaco, dentre outros fatores. Objetivo: O Diagnóstico depende de várias avaliações para sua definição. Sendo assim, o objetivo desse estudo é reunir os principais métodos laboratoriais utilizados nos laboratórios de análises clínicas, no Brasil. Materiais e métodos: Foram utilizados conteúdos dos últimos 8 anos para revisão bibliográfica, compostos por livros, artigos científicos, dissertações e órgãos. Através da busca nas seguintes bases de dados “Google Acadêmico” e “Sociedade Brasileira de Diabetes”. Resultados e Discussão: Sua identificação é realizada através dos seguintes exames: Para a glicemia de jejum, é de suma importância que o exame seja realizado com no mínimo 8 horas de jejum. Seu valor de referência é <100mg/dl, pré-diabetes vão de ≥100 a <126mg/dl e para DMT2 é ≥126 mg/dl. O teste oral de tolerância a glicose é realizado após 2 horas da ingestão de 75g de glicose em 250 a 300ml de água, fazer a ingestão durante 5 minutos. Esse exame deve seguir alguns critérios para sua execução, como jejum de 10 a 16 horas e fazer consumo de pelo menos 150g de carboidratos por dia durante os 3 dias anteriores. Seu valor de referência é <140mg/dl, pré-diabetes vão de ≥140 a <200mg/dl e para DMT2 é ≥ 200mg/dl. A Hemoglobina glicada não é específica para DMT2, podendo ter interferência de outras doenças e etnia para seu diagnóstico. O valor de referência para o DMT2 é ≥ 6,5%. Conclusão: É de suma importância um diagnóstico precoce e fidedigno do Diabetes Mellitus, para que medidas sejam tomadas antecipadamente impedindo seu desencadeamento ou postergar o surgimento de complicações crônicas nos indivíduos.
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Gupta, Rahul, Mamta Khosla, and Girish Wadhwa. "Design and Analysis of a Dual Material Triple Gate TFET with the Pocket Doping for the Performance Enhancement." In International Conference on Women Researchers in Electronics and Computing. AIJR Publisher, 2021. http://dx.doi.org/10.21467/proceedings.114.69.

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In this investigated work, we have analysed the miscellaneous figure of merit for Double metal Triple gate TFET. Various techniques have been utilized to improve the ON-state driven current in the drain by doing a comprehensive analysis. Different techniques are examined and correlated by using the TCAD Silvaco tool to get excellent ON current. Further work function engineering has been done in the optimized DMTG-TFET to increase its performance and finally, we introduce pocket doping that increases the ON current (2.34×10-3) and also ION/IOFF ratio (4.36×1014) with subthreshold (SS) of 25.8mV/decade. The pocket doped DMTG-TFET adequately suppress the ambipolarity and endeavour about 20 times higher ION as compared to conventional DMTG-TFET.
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Chen, Shia-Chung, Yaw-Jen Chang, Jen-An Chang, Hsin-Shu Peng, and Ying-Chieh Wang. "Dynamic Mold Temperature Control Using Gas-Assisted Heating and Its Effect on the Molding Replication Qualities of Micro Channels." In ASME 2008 International Manufacturing Science and Engineering Conference collocated with the 3rd JSME/ASME International Conference on Materials and Processing. ASMEDC, 2008. http://dx.doi.org/10.1115/msec_icmp2008-72458.

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Dynamic mold surface temperature control (DMTC) has the advantage of improving molded part qualities without significant increases in cycle time. A gas-assisted heating system combined with water cooling was developed to achieve DMTC for injection molding. With gas-assisted heating, it takes 2s for the mold surface temperature to vary from 60 °C to 120 °C whereas it requires 186s using water heating. Further, it takes 21s and 84s for the mold surface to cool to 60 °C under gas heating and water heating, respectively. The gas-assisted heating system also shows excellent efficiency for micro injection molding of biochips to achieve high replication accuracy of the micro channels.
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Godlewski, Tomasz, and Małgorzata Wszędyrówny-Nast. "Correlations of Regional Geotechnical Parameters on the Basis of CPTU and DMT Tests." In The 13th Baltic Sea Region Geotechnical Conference. Vilnius Gediminas Technical University, 2016. http://dx.doi.org/10.3846/13bsgc.2016.002.

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The requirements for field research for Polish conditions demand proper dependences. Dependences based on more than 30 localizations for different genetic types of soils were derived for the area of Poland. Direct results from CPT, DMT and profiles from boreholes have been collected at the test sites for individual localization. For interpretation of results, dependences and diagrams of CPTU versus DMT were created. Correlations on the background of results from literature for different types of soils for numerous research areas were collected, with established dependences for Polish grounds conditions. Additionally some recommendations for the interpretation of the results from CPTU and DMT tests for analysed soils have been proposed.
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Melo, Mirthys Alana Trajano da Silva, Thiago Emannuel Pessoa Da Silva, Luiza Smith Branquinho, Rebecca Francinny Silva Oliveira Pacheco, and Julya Myrrha Jenuino Feitosa Barroca. "A QUIMIOTERAPIA METRONÔMICA NO TRATAMENTO DE NEOPLASIAS MAMÁRIAS." In I Congresso On-line Nacional de Clínica Veterinária de Pequenos Animais. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/1821.

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Introdução: Neoplasias mamárias são as principais responsáveis pela mortalidade em animais de companhia. Um dos tratamentos é feito com a administração de fármacos citotóxicos que induzem danos químicos as células neoplásicas. A terapia mais utilizada segue o conceito da dose máxima tolerada (DMT) pelo paciente, tratamento este, cujos intervalos entre as doses favorece a regeneração das células endoteliais, permitindo a persistência da angiogênese tumoral. A Quimioterapia Metronômica (QM) consiste na observação dos agentes citotóxicos convencionais, administrados em baixas dosagens, exercendo efeitos antiangiogênicos, tornando-se uma alternativa pioneira viável para o tratamento de neoplasias mamárias, sendo um método de baixo custo que promove efeitos colaterais menores quando comparada a DMT. Objetivo: Analisar as implicações da QM em relação a terapia (DMT) no tratamento das neoplasias mamárias. Materiais e métodos: O presente estudo trata-se de uma revisão de literatura com base em dados adquiridos do Instituto Nacional do Câncer e Google Acadêmico. A pesquisa foi realizada a partir dos termos Quimioterapia animal, Quimioterapia Metronômica, Tratamento de câncer em animais e Quimioterapia convencional. Critérios para inclusão foram ano de publicação (2008 a 2016), ser do idioma português e os critérios de exclusão foram fuga parcial ou total aos objetivos da pesquisa e acesso pago. Resultados: Para amenizar os danos, efeitos colaterais e intervalos de tempo promovidos pela DMT, desenvolveram-se alternativas como a QM. O uso dessa terapia elimina longos períodos entre doses, diminuindo as chances de surgir alterações oportunistas nas células tumorais. O tratamento dos carcinomas mamários é feito pela administração oral de Ciclofosfamida em regime de QM através da ingestão do fármaco em baixa quantidade. Diferente da DMT que é realizada de maneira intravenosa. Evidências sugerem que a ciclofosfamida em regime de QM em cães e gatos, mostrou-se mais eficiente no tratamento de carcinomas mamários, em relação aos outros cânceres, devido ao seu efeito antigiogênico sobre as células tumorais. Conclusão: A comparação entre o tratamento com a terapia convencional e a terapia metronômica, mostrou que a QM é tão eficaz quanto a quimioterapia tradicional (DMT). Porém, a DMT ainda possui uma maior aplicabilidade, devido seus estudos e utilização mais prevalentes no campo veterinário.
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Neteler, Thomas, and Hardi Lobert. "Non-Destructive Testing Methods for Cables of Cable Supported Structures – Practical Experiences." In IABSE Conference, Seoul 2020: Risk Intelligence of Infrastructures. Zurich, Switzerland: International Association for Bridge and Structural Engineering (IABSE), 2020. http://dx.doi.org/10.2749/seoul.2020.372.

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<p>DMT’s Rope Testing Centre – a laboratory for non-destructive and destructive testing and part of TÜV NORD GROUP - has long-time experience in the inspection of steel wire ropes and cables in varying applications. DMT provides different non-destructive testing (NDT) methods, which allow a more detailed evaluation of the inner condition of the cables compared to only visual inspection. Ultrasonic testing (UT) at cable end connections is a very effective NDT method which is executed regularly by DMT experts. Another NDT method suitable to inspect the free length of stay or hanger cables is magnetic rope testing (MRT). Starting in 1931 with MRT on steel wire ropes, DMT has since then continuously developed and optimized this testing method and gained extensive operating skills.</p>
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Silva, Bruno Custódio, Gisele Delazeri, Ana Luíza Kolling Konopka, Giulia Righetti Tuppini Vargas, Paulo Ricardo Gazzola Zen, and Rafael Fabiano Machado Rosa. "Report of a family affected by fragile X syndrome and type 1 diabetes mellitus." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.076.

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Context: The fragile X syndrome is characterized by intellectual deficit and some physical characteristics, which become more evident during growth, especially craniofacial and macroorchidism. Case report: A 22 year-old male patient with diabetes mellitus type 1 (DM1) diagnosed at 7 years of age is following-up with ophthalmology due to low visual acuity. On physical exam, he did not maintain eye contact and performed repetitive movements. In addition, he had an elongated face and upward slanting eyelid clefts, a high palate and prognathism, large and prominent ears. In the family history, 3 of his siblings, one male and two female, also had intellectual deficit, and two of them had concomitant DM1. One brother had only DM1 and the other none of the diseases. The parents had consanguinity (they were cousins in the 3rd degree). The patient’s karyotype, using the chromosomal breaks technique after cultivation in medium-low folic acid, showed the presence of fragility on the X chromosome in the region q27.3 [46, XY, fra (x) (q27.3)], compatible with the diagnosis of fragile X syndrome. This result was confirmed using the PCR-multiplex technique. Conclusions: In this family, the concomitant presence in several individuals of the fragile X syndrome and DM1 stands out. However, although both conditions are not related, they are frequent, which could justify their simultaneous occurrence.
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"DMTS 2019 Organizing and Program Committee." In 2019 IEEE SmartWorld, Ubiquitous Intelligence & Computing, Advanced & Trusted Computing, Scalable Computing & Communications, Cloud & Big Data Computing, Internet of People and Smart City Innovation (SmartWorld/SCALCOM/UIC/ATC/CBDCom/IOP/SCI). IEEE, 2019. http://dx.doi.org/10.1109/smartworld-uic-atc-scalcom-iop-sci.2019.00040.

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Reports on the topic "DMT1"

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Hu, Yalin, Dustin Tso, Sarina Kapai, and Marc Feldman. D-DMTD: Digital Dual Mixer Time Difference. Office of Scientific and Technical Information (OSTI), September 2017. http://dx.doi.org/10.2172/1494164.

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Favorite, Jeffrey A. (U) Neutron-Induced Gamma-Ray Calculations Using DMTK. Office of Scientific and Technical Information (OSTI), September 2015. http://dx.doi.org/10.2172/1214636.

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Brenner, Matthew. Acceleration of Advanced CN Antidote Agents for Mass Exposure Treatments: DMTS. Fort Belvoir, VA: Defense Technical Information Center, December 2014. http://dx.doi.org/10.21236/ada613637.

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Temple, Brian, and David Pimentel. LANL12-RS-108J Device Modeler Tool Kit - DMTK Final Report for FY14. Office of Scientific and Technical Information (OSTI), September 2014. http://dx.doi.org/10.2172/1158828.

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Temple, Brian Allen, and David A. Pimentel. LANL12-RS-108J Report on Device Modeler Testing of the Device Modeler Tool Kit. DMTK in FY14. Office of Scientific and Technical Information (OSTI), September 2014. http://dx.doi.org/10.2172/1158829.

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Maglic, Dejan. MEKK1 is a Novel Regulator of the Dmp1-Arf-p53 Pathway and Prognostic Indicator in Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, December 2012. http://dx.doi.org/10.21236/ada574517.

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Haase, C. S. Geophysical data from boreholes DM1, DM2, DM3, and DM3a, New Hydraulic Fracturing Facility, Oak Ridge National Laboratory, Oak Ridge, Tennessee. Office of Scientific and Technical Information (OSTI), March 1987. http://dx.doi.org/10.2172/6430979.

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Hendricks, M. D., P. G. Ekberg, J. E. Athey, and A. E. Macpherson. Symbolizing a GeMS Geodatabase (presentation): U.S. Geological Survey Digital Mapping Techniques Workshop Series DMT 2021 (A Virtual Event), June 7-10, 2021. Alaska Division of Geological & Geophysical Surveys, June 2021. http://dx.doi.org/10.14509/30826.

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Hendricks, M. D. Customizing the GeMS Toolbox for local requirements (presentation): U.S. Geological Survey Digital Mapping Techniques Workshop Series DMT Lite 2020 (A Virtual Event), Dec 8, 2020. Alaska Division of Geological & Geophysical Surveys, December 2020. http://dx.doi.org/10.14509/30858.

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Hendricks, M. D., A. E. Macpherson, and P. G. Rivera. Visualization considerations with GeMS data and maps (presentation): U.S. Geological Survey Digital Mapping Techniques Workshop Series DMT Lite 2021 (A Virtual Event), Dec 6-7, 2021. Alaska Division of Geological & Geophysical Surveys, December 2021. http://dx.doi.org/10.14509/30827.

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