Dissertations / Theses on the topic 'DMI'
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Barton, Wayne Robert. "Sensitivity of Sclerotinia homoeocarpa to the DMI fungicide propiconazole." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/MQ40395.pdf.
Full textKonečný, Jiří. "Posouzení účinnosti filtračního materiálu DMI-65 na odstraňování kovů z vody." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2016. http://www.nusl.cz/ntk/nusl-240478.
Full textUllah, Ikram [Verfasser], and Alexander [Akademischer Betreuer] Brehm. "Characterization of RNA interactions of dMi-2 / Ikram Ullah ; Betreuer: Alexander Brehm." Marburg : Philipps-Universität Marburg, 2021. http://d-nb.info/1236692152/34.
Full textJonason, Nicolas. "Investigating parameter mapping of the digital musical instrument Force Ghost." Thesis, KTH, Medieteknik och interaktionsdesign, MID, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-189333.
Full textDenna artikel utreder två mappningar av två parametrar hos det digitala musikaliska instrumentet Force Ghost. Instrumentet ljuder genom att en ljudkälla filtreras av bandpassfilter. Ljudkällan i detta fall är ljudet av regnfall i en skog. Varje tangent på ett keyboard är kopplat till minst ett bandpassfilter, vars MIDI-not kopplat till motsvarande frekvens. Denna frekvens är bandpassfiltrets centerfrekvens. När en tangent nedtrycks genereras bandpassfiltret, vilket skapar en ton ur ljudkällan. De två parametrarna i fokus är kopplade till bandpassfiltrerna. De är Q-värdet (kopplat till bandpassfiltrernas bandbredd) och klangfärgen (kopplat till övertonerna; vilka de är och deras amplitudrelation för varje not). Dessa två parametrar är mappade till modulations-hjulet och pitchbend-hjulet. Mappningen av dessa parametrar är undersökt genom musikuppgifter och självständig utforskning genomförda av musiker. Detta spelades in och sedan utfördes en semistrukturerad intervju med musikerna. Intervjuerna visade att modulations-hjulet föredrogs på grund av avsaknaden av fjädermekanismen som finns hos pitchbend-hjulet. Denna mekanism tvingar pitchbend-hjulet tillbaka till sin utgångsposition (i mitten) när den släpps. Resultaten från musikuppgifterna indikerar att ingen av sensorerna har bättre kontrollbarhet än den andre, oavsett vilket parameter den kontrollerar. Sammanfattningsvis, en sensor som graviterar mot ett viloläge verkar inte vara lämplig för att kontrollera en parameter (-skalning) som saknar ett “vilovärde” (så som uppfattat av musiker).
Mathieu, Eve-Lyne [Verfasser], and Alexander [Akademischer Betreuer] Brehm. "Genome-wide analysis of dMi-2 binding sites / Eve-Lyne Mathieu. Betreuer: Alexander Brehm." Marburg : Philipps-Universität Marburg, 2013. http://d-nb.info/1045729639/34.
Full textGama, André Bueno. "Podridão floral dos citros: definição do limiar de ação para controle químico e monitoramento da sensibilidade de isolados a tebuconazol e trifloxistrobina." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/11/11135/tde-19102017-105445/.
Full textBrazilian citrus industry represents a significant share in the global citrus market. Amongst several diseases that affect the crop, postbloom fruit drop (PFD) has been gaining prominence in Sao Paulo with the displacement of citrus areas to regions in which weather conditions are more favorable to the occurrence of this disease. PFD, caused by species of the complexes Colletotrichum acutatum and C. gloeosporioides, is especially problematic in years of mild temperatures and high humidity. Citrus growers spray the orchards preventively for PFD control every year, although favorable climatic conditions do not occur regularly. In addition to the economic impact, this practice increases the selection pressure of fungicide resistant isolates, and may decrease the efficiency of chemical control in a long term. The use of disease forecasting systems is able to prevent unnecessary fungicide sprays. For the development of such systems, it is essential to determine an action threshold for the application of fungicides in the orchards. The objectives of this work were: (i) to establish an action threshold for fungicide sprays based on the germination of C. acutatum conidia; (ii) to characterize the sensitivity of C. gloeosporioides and C. acutatum isolates to trifloxystrobin and tebuconazole in vitro and molecularly. Regarding the definition of the action threshold, treatments based on risk indices were compared to the control treatments and calendar based sprays, usually adopted by growers. The 15% conidia germination threshold was efficient in controlling the disease and reducing the number of fungicide applications. In the fungicide sensitivity tests, two methods were used to determine the EC50, the spiral gradient dilution for trifloxystrobin and tebuconazole, and the method of conidial germination inhibition for trifloxystrobin. Isolates collected between 1999 and 2016 were used. The mean EC50 of the isolate collection determined by the spiral gradient dilution method ranged from 0.158 to 0.297 μg/ml and from 0.1 to 0.182 μg/ml for trifloxystrobin and tebuconazole, respectively. Mean EC50 of trifloxystrobin estimated by the conidial germination inhibition method was 0.002 μg/ml. No mutations or EC50 values indicated shifts of fungicide sensitivity on the isolates.
Bouloussa-Huynh, Hedi. "Spectroscopie Brillouin dans les couches minces, multicouches et nanostructures magnétiques : étude de l’interaction Dzyaloshinskii-Moriya." Thesis, Paris 13, 2019. http://www.theses.fr/2019PA131025.
Full textThis work aims to investigate, experimentally and theoretically, the behavior of spin waves (SW) in ultrathin layers, multilayers and magnetic nanostructures in the presence of interface Dzyaloshinskii-Moriya interaction (DMI). For this purpose, we used the Brillouin light scattering spectroscopy (BLS) as an experimental probe. This technique has proven to be an efficient tool for measuring the DMI; an effect that results in an asymmetry of the Stokes and anti-Stokes lines of a BLS spectrum for a thin ferromagnetic film in contact with a heavy metal producing a strong spin-orbit coupling (SOC). Thus, in the presence of DMI, the frequencies of two SW propagating in opposite directions will be different due to inversion symmetry breaking.Different systems were discussed and different situations and parameters were considered.On simple ultrathin layer systems, the behavior as a function of the thickness of themagnetic film or the effect of annealing have been identified, highlighting the interfacial nature of the DMI and the role of the structural and chemical quality of the ferromagnetic/heavy metal interface.Moreover, we have shown that the addition of non-magnetic impurities with high SOC in light metals interfaced with a ferromagnetic layer can be an effective approach to simultaneously improveand control magnetic damping, perpendicular anisotropy and DMI. A correlation between these SOC parameters has been also demonstrated. In thin film stacks, particular attention has been dedicated to the role of dipolar coupling,exchange coupling and magnetic anisotropy on the behavior of SW in the presence of DMI. It appears that the quantitative measurement of the DMI can deviate significantly from that obtained from the analytical expression known for simple thin layers where the value of the DMI is directly proportional to the wave vector of the SW. A complete calculation is thus necessary for all non-symmetrical cases (non-equivalent interfaces, different interface anisotropies, etc. . . ).The theoretical results presented for this purpose represent an extremely useful tool.The study of different nanostripes arrays in presence of DMI was the opportunity to highlight the effects of size and periodicity in different situations. Completely decoupled nanostripes or inpartial physical contact with periodic layer thickness were discussed. We have thus demonstrated the absence of DMI for stationary spin waves according to the width of the decoupled stripes and correlated the behavior of the SW with their attenuation length and the periodicity of the arrays, whereas a modulated magnetic behavior by the presence of the DMI was observed for the coupled stripes via a ferromagnetic film.The results obtained in this thesis work contribute to the understanding of the dynamic magnetic behavior of systems in the presence of DMI that can contribute to the efficient engineering of future systems for spintronics or spin-orbitronics, particularly based on configurations of chiral spin texture such as skyrmions
Figueira, Paulo da Silva. "Diagnóstico das propriedades de consistência temporal em DMI`s: uma abordagem baseada na TDF RT-LOTOS." Master's thesis, Universidade da Madeira, 2007. http://hdl.handle.net/10400.13/138.
Full textKovač, Kristina [Verfasser], and Alexander [Akademischer Betreuer] Brehm. "Functional characterisation of cancer-associated mutations in the chromatin remodeler CHD4/dMi-2 / Kristina Kovač ; Betreuer: Alexander, Brehm." Marburg : Philipps-Universität Marburg, 2018. http://d-nb.info/1161876197/34.
Full textSartorelli, Isabel Cristina. "Análise do padrão decisório do auditor brasileiro com uso da metodologia Q e do DMI (Decision Making Inventory)." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/12/12136/tde-26052015-115217/.
Full textThis doctoral dissertation analyzes the decision making style of the Brazilian auditor (from the point of view of the Dual Process Theory in its version modified by Regret Theory, here called TPD-m), since the decision-making pattern yield information about the way in which the auditor make judgments. Considering that auditor and accounting standard must be aligned, and considering the adoption of principle-based standards (IFRS), the objective was to deepen the studies of Jamal and Tan (2010), trying to identify whether the types of auditors identified by them (oriented by principles, by rules and by clients) could be empirically observed in the defined sample (29 partners and 35 managers of Large Six Brazilian audit firms), and whether it could find support in the literature that defines the main features of these types of auditors. The four research hypothesis were about: the lack of predominance of a single decision-making standard; the association between the patterns identified by DMI (if analytical, intuitive or emotional) and the types of auditors; homogeneity in determining what would be considered more important an audit in leasing; the existence of an association between the clusters identified by the Q Methodology and characteristics consistent with the types of auditors identified by Jamal and Tan (2010). The first hypothesis was verified with DMI Test; findings indicates that the predominant profile of auditors is analytical (explained by the accountability process experienced by professionals), which provides necessary support to affirm that the decisions taken by auditors are deliberate and carefully analyzed (if they have time available for analysis). With this result, it was not possible to verify the second hypothesis (there was no sufficient intuitive and emotional individuals to establish the desired association). The third hypothesis was verified by a lease exercise based on the Methodology Q; findings indicates no uniformity in determining what would be considered most important among the participants (in this analysis, it is clear the subdivision of analytical participants into two groups: the first focuses on the lease agreements, and the second on fair value\'s definition). The fourth hypothesis was verified by analyzing the most repeated words observed in the transcripts of the interviews, and the result indicates that there may be correspondence between the clusters of Q Methodology and types of auditors oriented by principles and by rules (it was not possible to conclude on the existence auditors oriented by clients). About the methods employed: the result of the lease exercise corroborates the DMI Test, as in the whole group of participants was identified analytical choosing an analytical attitudes (more literal content, more objective); Q methodology seems to be efficient in the analysis of the application of the accounting standard by the participants. About theoretical contribution: the approach of TPD-m helps to explain the empirical evidence collected; furthermore, the discussion involving jointly agent and accounting standards, the concept and utility of accounting principles and rules in the judgment and decision making process contributes to the consolidation of research in this area.
Rallos, Lynn Esther Espada. "Characterizing resistance of Erysiphe necator to fungicides belonging to the quinone outside inhibitors and demethylation inhibitors." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/49594.
Full textDMI resistance mechanisms in E. necator included the Y136F mutation in CYP51 and cyp51 over-expression. The first mechanism was present in almost all isolates with substantial levels of resistance, and cyp51 expression level was correlated with resistance level. Three cyp51 genotypes were detected. Wildtype isolates with the TAT genotype were sensitive to DMIs, while isolates with increased resistance had either a TTT or TWT genotype; TWT indicated the presence of both wildtype and mutant alleles. Cyp51 was expressed 1.4 to 19 times more in mutants than in wildtype. It is not known whether the significant differences in cyp51 expression level among isolates and among genotype groups are due to gene copy number variation. DMI resistance was found to decline after years of subculturing, and the decline appeared to occur after a few culture transfers of field samples on fungicide-free host leaves. The observed decline, together with the finding that isolates could be "trained" to increase resistance, and may be slightly induced in cyp51 expression when successively challenged to grow in increasing fungicide concentration, indicate instability of DMI resistance.
Ph. D.
Lopez, Alexandre. "Étude de la dynamique de paroi de domaine magnétique dans des matériaux à fort couplage spin orbite." Thesis, Université Grenoble Alpes (ComUE), 2015. http://www.theses.fr/2015GREAY037/document.
Full textIn this thesis, we studied the current induced domain walls (DWs) dynamics in ultra-thin ferromagnetic films of heavy metal/ ferromagnetic metal/ oxide type with a high spin-orbit coupling. In these systems, two ingredients linked to the high spin-orbit coupling and the structural inversion asymmetry play a key role on the DWs dynamics: the amplitude of the spin-orbit torques (SOT) acting on the domain when a current is injected; and the amplitude of the Dzyaloshinskii-Moriya interaction (DMi) which stabilizes the Néel structure of the DW. The purpose of this work was to characterize the current induced torques acting on the DW and the amplitude of the DMi.For that purpose, I developed a new measurement technique relying on the measurement of current induced nanometer size motion of a DW, trapped inside a nanodot patterned in the magnetic material. This quasi-static measurement enables to avoid the difficulties related to the modelling of the DW dynamics in the presence of defects.Besides that, the device has been designed to enable different perpendicular directions for the current and the external magnetic field, which enable a clear measurement of spin transfer (NA-STT) and spin-orbit (DL-SOT) torques contributions.The measurements allowed the characterization of the torque exerted by the current on the DW with respect to a planar magnetic field for a Pt/Co/AlOx stack in 4 different couples of field/current directions. The results allow to exclude the hypothesis of a Bloch structure for the DW.In the case where the current is injected through the DW, the comparison between the results and the model leads to a very weak value for the NA-STT. Our measurements made with the planar magnetic field leads to a value of 7,5+/-0,5 Oe per 10 MA/m² for the DL-SOT, which is in agreement with previously published results in the case of a Néel DW. If both configurations lead to similar measurements for the SOT, they don't permit to conclude on the exact value of the DMi in this system. The origin of these contradictories values is still to be understood
Bigot, Anne. "Mécanismes de sénescence et programme myogénique." Paris 6, 2007. http://www.theses.fr/2007PA066397.
Full textSchott, Marine. "Propriétés magnétiques du système Pt/Co/AlOx et ses variations sous champ électrique." Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAY032/document.
Full textA current challenge in the field of spintronics is the development of functional nanospintronics systems, in which the dimensions of the device are confined to the nanometer scale. The model system is called a single nano-magnet. New possible routes to control its magnetisation could be useful for many applications, in particular, those in the area of information technology. During this PhD, we chose to study the particular effects that are linked to the electric charge accumulation in the nano-magnet. This effect, also known as the electric field effect, were studied on the different magnetic properties of our films. They were probed by magneto-transport and magnetooptical measurements. These measurements were conducted on asymmetric Pt/Co/AlOx trilayers. These structures were sputter-deposited on a wedge shape for the alumina. This leadingto a nanometric control of the oxidation degree of the interface. Then, a wide range of magnetic parameters is available on a unique sample. Systematic caracterization of these structures showed an interesting zone for magnetic properties (spontaneous striped domains, skyrmionic bubbles). The observation of this type of magnetic object is directly linked to the weak Curie temperature(Tc) of this zone (close to room temperature. Skyrmionic bubbles are subject to lots of international studies. They are potentially attractive for memories or logic devices development. The key result of this PhD was to show the strong dependence of magnetic skymionic bubbles with electric field application. The full electrical switch of these objects has been achieved, due to the strong electrical control of the different magnetic properties. To induce electric-field assisted magnetisation reversal/skyrmionic bubbles nucleation, studies were performed for an adapted range of temperatures and anisotropies (room temperature)
Keegan, Neil Patrick. "The design marketing interface (DMI) in high technology, small to medium sized enterprises : a product/sector specific study relating to SMEs utilising digital electronics." Thesis, University of Huddersfield, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323782.
Full textOrsoletta, Aline Cristina Dall. "Efeito do pastejo e do momento de acesso ao pasto sobre a ingestão, o desempenho e a emissão de metano em vacas leiteiras." Universidade do Estado de Santa Catarina, 2016. http://tede.udesc.br/handle/handle/2362.
Full textMade available in DSpace on 2018-02-15T15:43:47Z (GMT). No. of bitstreams: 1 PGCA16MA185.pdf: 387046 bytes, checksum: c4b42029e4e9bd31fb6f0967fb2fe202 (MD5) Previous issue date: 2016-02-22
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The inclusion of pasture in dairy feeding systems based on a total mixed ration (TMR) reduces feed costs, benefits herd health and reduces environmental impact. The present study aimed to evaluate the effect of ryegrass pasture (Lolium multiflorum Lam.) combined with a partial TMR or a TMR on the enteric methane emissions, dry matter intake (DMI), and performance of dairy cows from mid- to late lactation. The experimental treatments included 100% TMR (control), partial TMR + 6 h of continuous grazing (0900 – 1500 h) and partial TMR + 6 h of grazing that was divided into 2 periods of 3 h after milking (0900 – 1200 h; 1530 – 1830 h). Twelve F1 cows (Holstein × Jersey; 132 ± 44 days in milk) were divided into 6 lots and distributed in a 3 × 3 Latin square design with 3 periods of 21 d (15 d of adaptation and 6 d of evaluation). Ryegrass pasture was used, and the TMR was composed of 80% corn silage, 18% soybean meal, and 2% mineral and vitamins mixture, based on dry matter (DM). The same mixture was used for cows with access to pasture. The total DMI (average = 16.1 kg/d) and milk production ( average = 20.0 kg/d) were similar for all cows; however, the pasture DMI (7.4 vs. 6.0 kg/d) and grazing period (+ 40 min/d) were higher in cows that had access to pasture for 2 periods of 3 h compared to those that grazed for a continuous 6 h period. Methane emission was higher (656 vs. 547 g/d) in confined cows than in those receiving partial TMR + pasture. The inclusion of ryegrass pasture in the diet of dairy cows maintained animal performance and reduced enteric methane emissions. The percentage of grazed forage in the cow’s diet increased when access to pasture was provided in 2 periods after morning and afternoon milking
A inclusão da forragem em sistemas de produção de leite baseados em ração totalmente misturada (RTM) reduz os custos com a alimentação, traz benefícios à saúde do rebanho e reduz o impacto ambiental. O presente estudo objetivou avaliar o efeito do pastejo de azevém (Lolium multiflorum Lam.) combinado com o uso de RTM parcial em comparação à RTM sobre a emissão de metano, a ingestão de matéria seca (IMS) e o desempenho das vacas no terço médio de lactação. Os tratamentos experimentais foram 100% RTM (controle), RTM parcial + 6h de pastejo contínuo (09:00–15:00h) e RTM parcial + 6 h de pastejo divididos em dois períodos de três horas (09:00 – 12:00 h; 15:30 – 18:30h). Doze vacas F1 (Holandês × Jersey; 132 ± 44 DEL) foram divididas em seis lotes e distribuídas em um Quadrado latino com três períodos de 21 dias (15 dias de adaptação e 6 de dias avaliação). O pasto utilizado foi o azevém e a RTM foi composta de 80% de silagem de milho, 18% farelo de soja, e 2% de mistura mineral e vitaminas (na matéria seca, MS). A mesma mistura foi utilizada para as vacas com acesso ao pasto. A IMS total (média = 16,1 kg MS/dia) e a produção de leite (média = 20,0 kg leite/dia) foram similares entre os tratamentos, entretanto, a IMS de pasto (7,4 vs. 6,0 kg/d) e o tempo de pastejo (+ 40 min/d) foram superiores nas vacas com acesso ao pasto por dois períodos de 3h quando comparadas às vacas com acesso ao pasto por 6h contínuas. A emissão de metano foi maior (656 vs. 547 g/d) nas vacas confinadas do que nos animais recebendo RTM parcial + pasto. A inclusão de pasto de azevém na dieta de vacas leiteiras recebendo RTM manteve o desempenho animal e reduziu a emissão de metano entérico. A proporção de forragem pastejada aumentou nas vacas com acesso ao pasto quando o período de acesso foi dividido em dois períodos após a ordenha da manhã e a ordenha da tarde
Oliveira, Luciano Santos. "Prevalência do polimorfismo -1031 T>C do gene TNFA em um grupo de diabéticos tipo I e sua relação com a periodontite severa." Universidade do Estado do Rio de Janeiro, 2009. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=6756.
Full textDiabetes mellitus e doenças periodontais são altamente prevalentes na população mundial. Doenças periodontais (DPs) compreendem um grupo de condições crônicas inflamatórias induzidas por microorganismos que levam à inflamação gengival, à destruição tecidual periodontal e à perda óssea alveolar. Diabetes mellitus (DM) é o termo utilizado para descrever um grupo de desordens metabólicas associadas à intolerância à glicose e ao metabolismo inadequado de carboidratos. Uma vez que DPs poderiam agir de forma similar a outros estados infecciosos sistêmicos, aumentando a severidade do diabetes, uma possível relação entre ambas tem sido considerada em todo o mundo. Polimorfismos genéticos de um único nucleotídeo (SNPs) têm sido estudados em diversas doenças. Nas periodontites, acredita-se que possam estar envolvidos na exacerbação da resposta inflamatória frente ao desafio bacteriano, modificando a susceptibilidade do hospedeiro. Neste estudo, a prevalência de periodontite foi avaliada em portadores de diabetes mellitus tipo I. Posteriormente, o SNP localizado na região promotora do gene TNFA (-1031T>C) foi analisado e sua importância para a doença periodontal destrutiva foi avaliada. O grupo teste foi constituído por diabéticos tipo I (DGT, n=113) enquanto o grupo controle por indivíduos não diabéticos (ND, n=73). Para as análises dos polimorfismos genéticos, um subgrupo foi retirado do grupo teste (DG, n=58) e comparado ao grupo ND. Os seguintes parâmetros clínicos e demográficos foram avaliados: percentual de sítios com profundidade de bolsa 6,0 mm (%PBS6,0 mm); índice gengival (IG); perda óssea radiográfica (POR); fumo; duração do diabetes ; idade; índice de massa corpórea (IMC), n de internações e n de dentes presentes. Amostras de sangue e/ou esfregaço bucal foram colhidas de 58 pacientes do grupo teste e de 73 controles. Após a extração do DNA genômico e amplificação da região genômica de interesse por PCR (Polymerase Chain Reaction), o polimorfismo TNFA 1031T>C foi analisado por BbsI RFLP (Restriction Fragment Length Polymorphism). A análise dos produtos de digestão foi feita por eletroforese em gel de poliacrilamida 8%. A análise estatística das freqüências alélica e genotípica juntamente com os dados clínicos e epidemiológicos entre os 2 grupos foi feita através do teste do Mann-Whitney e do Qui-quadrado. Os grupos de estudo obedecem ao princípio de Hardy-Weinberg. No grupo ND, as seguintes freqüências genotípicas foram encontradas: 78,1% (T/T); 20,5% (T/C) e 1,4% (C/C) enquanto no grupo D foram: 42,4%(T/T); 37,3% (T/C) e 20,3% (C/C). A frequência do alelo T no grupo diabético (D) foi de 0,610 ao passo que no grupo ND foi de 0,883. Não foi possível encontrar uma relação entre o polimorfismo -1031 T>C do gene TNFA e a presença de periodontite em diabéticos tipo I. Entretanto, o polimorfismo estudado se mostrou significativamente relacionado (p<0,0001 e OR= 4.85 95%IC 2,271-10,338) à presença do diabetes tipo I.
Diabetes mellitus and periodontal diseases are highly prevalent worldwide. Periodontal disease (PD) combines a group of chronic inflammatory conditions induced by microorganisms that leads to gingival inflammation, periodontal tissue destruction and alveolar bone loss. Diabetes mellitus (DM) is a term used to describe a group of metabolic disorders associated to glucose intolerance and inappropriate carbohydrate metabolism. Once PDs could act in a similar way to other systemic infectious states increasing diabetes severity, a possible correlation between both has been considerate around the world. Single nucleotide polymorphisms (SNPs) have been studied in relation to several diseases. In periodontitis, it is believed to be involved in an exacerbated inflammatory response due to bacterial challenge, modifying the host susceptibility. In this study, the prevalence of periodontal disease was evaluated in type I diabetes patients (TIDM). Further on, the SNP in the promoter region of the TNFA gene (-1031T>C) was analyzed and its importance to destructive periodontal disease was considered. The test group was formed by type I diabetic patients (TDG, n=113) and the control group was composed by non-diabetic patients (ND, n=73). For the genetic polymorphism analysis a subgroup was taken from the test group (DG, n=58) and compared to the ND group. The following clinical and demographic parameters were assessed: percentage of sites with periodontal pocket depth (PPD) 6.0mm; gingival index (GI); radiographic bone loss (RBL); smoking habits; diabetes duration; age; bone mass index (BMI); number of admissions and number of teeth. Blood samples and oral epithelial cells were collected from 58 patients of the test group and 73 controls. After genomic DNA extraction and amplification of the genomic region of interest by PCR (Polymerase Chain Reaction), the TNFA 1031T>C polymorphism was analyzed by BbsI RFLP (Restriction Fragment Length Polymorphism). Analysis of the digestion products were performed by 8% polyacrylamide gel electrophoresis. The statistical analysis of the genotypes and allelic frequencies along with the clinical and epidemiological data between the two groups were done through the Mann-Whitney and Chi-square tests. The study groups are in Hardy-Weinberg equilibrium. In the ND group, the following genotypic frequencies were found: 78.1% (T/T); 20.5% (T/C) e 1.4% (C/C), while for the D group, they were: 42.4% (T/T); 37.3% (T/C) e 20.3% (C/C). The frequencies of T allele in the D and ND groups were 0.610 and 0.883, respectively. It was not possible to find any correlation between the -1031 T>C promoter polymorphism of the TNFA gene and the presence of periodontitis in type I diabetic patients. However the studied polymorphism showed to be significantly related (p<0.0001 and OR=4.85 95%CI 2.271-10.338) to the presence of type I diabetes mellitus.
Nsibi, Mohamed Ali. "Asymmetric magnetic domain walls motion in a two-dimensional geometry : causes and effects." Thesis, Université Grenoble Alpes (ComUE), 2019. http://www.theses.fr/2019GREAY047.
Full textThe study of the current-induced magnetic domain walls motion has attracted a lot of interest since the report of their large velocities of motion in thin layers with structural inversion asymmetry (SIA). This interest comes from their high potential for low power consumption functionalities in cache and main memories applications. The SIA induces two mechanisms whose combined action allows to drive efficiently the domain walls. The two mechanisms are the chiral energy term, called the Dzyaloshinskii-Moriya interaction (DMI), and the spin-orbit torques (SOT). This model is still incomplete since it does not explain several experimental results. In addition, a chiral dissipation term called the chiral damping, also induced by SIA, has recently been proposed. However, its effect on current-induced domain wall motion has not been studied.The objective of this work was to bring a more detailed understanding of the interactions involved in the domain wall motion. To that end, I have studied the domain wall motion in a non-collinear geometry with respect to the current, in materials with different SIA (Pt/Co/Pt and Pt/Co/AlOx). This motion has been found to be asymmetric. It illustrates the interplay between chiral energy and chiral dissipation in current-induced domain wall motion in weak SIA materials. In large SIA materials, the DMI and SOT model, even in the flow regime of motion, cannot explain this asymmetry. I have also evidenced that the asymmetric non-collinear domain wall motion induces a well-defined deflection of the skyrmion bubbles. This is the first observation of the extrinsic skyrmion Hall effect.The results of this thesis contribute to the understanding of the physical mechanisms behind domain wall and skyrmion motion in ultrathin layers by evidencing supplementary effects from SIA
Svensson, Louise, and Drugge Gabriella Andersson. "Tillsatser i polyestertextil : Avlägsnande av dispersionsfärg inför mekanisk återvinning genom omsmältning." Thesis, Högskolan i Borås, Akademin för textil, teknik och ekonomi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-10468.
Full textAhmed, Adam Saied. "Skyrmions and Novel Spin Textures in FeGe Thin Films and Artificial B20 Heterostructures." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1492686407034025.
Full textTran, Mykien. "Microencapsulation de protéines dans des systèmes polymériques par des procédés sans solvants toxiques, en particulier la technologie des fluides supercritiques." Phd thesis, Université d'Angers, 2013. http://tel.archives-ouvertes.fr/tel-00952800.
Full textDesai, Shital H. "Embodied intuitive interaction in children." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/112766/8/112766.pdf.
Full textSABBATINI, DANIELE. "Identificazione e caratterizzazione dei modificatori genetici della DMD." Doctoral thesis, Università degli studi di Padova, 2022. http://hdl.handle.net/11577/3458325.
Full textBackground: Despite promising advances made in the past 30 years owing to the identification of the molecular bases of Duchenne muscular dystrophy (DMD), several obstacles remain for a full translation of novel therapies into clinical practice, and DMD patients and their families must still cope with severe disability and grim perspectives for the future. One of the most challenging hurdles to the success of clinical trials is the considerable inter-patient variability in terms of age at presentation, weakness progression, and degree of involvement of the central nervous system (CNS) observed in DMD, that is, the relevant phenotypic variability of DMD. The genetic background, that is, variations in genes different from disease genes, is increasingly believed to modulate the phenotype of Mendelian diseases. These trans-acting variants are called genetic modifiers. In this thesis, we aimed to deepen current understanding of these mechanisms. Therefore, the following aims were formulated. Aims: • In this project, we aimed to perform a genome-wide association study (GWAS) to search for DMD modifier loci, leveraging on clinical data and DNA samples from a large cohort of DMD patients followed by the Consortium of Italian Centers, which has collaborated to study DMD natural history over the past decade. In this thesis we present preliminary data on 265 DMD patients, but the final GWAS (still in progress, delayed by the Covid-19 pandemic) will include 700+ patients. • We also aimed to identify candidate variants involved in the modulation of the CNS phenotype in dystrophinopathies, by performing whole genome sequencing (WGS) in a pair of DMD siblings with discordant cognitive phenotypes and by filtering variants using a dedicated bioinformatic algorithm. • Lastly, we aimed to verify if known genetic modifiers of loss of ambulation (LoA) in DMD, both cis and trans acting, also affect the Performance of the Upper Limbs measured with the PUL test. Moreover, all associations were tested for validation in an independent cohort (i.e. Cooperative International Neuromuscular Research Group Duchenne Natural history Study, CINRG-DNHS) in which patients had been tested using the Brooke scale for upper limb function. Results: • We identified a list of SNPs with a suggestive p value, revealing the presence of a candidate locus in chromosome 1, at a distance of ~3,800 bp upstream of the C1orf21 locus, whose functional meaning needs to be further elucidated. • Regarding WGS in a pair of DMD siblings with discordant cognitive phenotypes, we focused our attention on two SNPs, and a deletion resulting from the breakdancer analysis. All of these variants reside within in a risk-genes for autism, and are co-expressed with dystrophin. The first one is a single SNP upstream of ANK3, and the second an intronic variant in NRXN3, encoding the dystrophin-associated glycoprotein neurexin 3. Both of these variants were previously identified in a WGS study of ASD twins. In our family, the younger brother (suffering from ASD) was heterozygous for both of these variants, while the elder was homozygous for the wild-type allele at both loci. • Finally, significant associations were observed between additive CD40 rs1883832 genotype and shoulder/distal PUL subscores, with a trend of association in the total score. Additive ACTN3 rs1815739 genotype was also significantly correlated with elbow and distal subscores Moreover, it was possible to assess a significant association of CD40 rs1883832 and SPP1 rs28357094 with the Brooke score in the CINRG-DNHS cohort.
Saab, Junior Joseph Youssif. "Administração da cadeia de abastecimento: considerações sobre a situação estratégica dos distribuidores paulistas de um fabricante multinacional de produtos de consumo da área de saúde e higiene pessoal e proposta do sistema de estoque gerido pelo distribuidor (EGD/DMI)." reponame:Repositório Institucional do FGV, 2003. http://hdl.handle.net/10438/5836.
Full textAnalisa o comportamento dinâmico de cadeias de distribuição genéricas e de uma cadeia específica. Avalia o motivo pelo qual o sistema de Estoque Gerido pelo Fabricante, EGF ou VMI, não apresenta os resultados esperados em determinadas situações. Propõe um novo modelo de gerenciamento da cadeia de abastecimento, coordenado pelo Distribuidor, o Estoque Gerido pelo Distribuidor, EGO ou DMI. Analisa o resultado desta nova proposta sob os aspectos estratégico, dinâmico e econômicofinanceiro
Garavello, Silvia <1975>. "ANALISI DEI REPERTI FAUNISTICI PROVENIENTI DAI RECENTI SCAVI DI COMACCHIO (FE)." Master's Degree Thesis, Università Ca' Foscari Venezia, 2012. http://hdl.handle.net/10579/1582.
Full textRusso, Francesco. "Tecniche di monitoraggio dei flussi veicolari: dai metodi tradizionali al telerilevamento satellitare." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019.
Find full textCarioli, Stefania. "Nel labirinto dei link. Dai “vincoli” della linearità alla complessità della lettura online." Doctoral thesis, Università di Firenze, 2015. https://hdl.handle.net/11576/2707734.
Full textCALEGARIO, Filipe Carlos de Albuquerque. "Sketchument: ambiente de experimentação para criação de instrumentos musicais digitais." Universidade Federal de Pernambuco, 2013. https://repositorio.ufpe.br/handle/123456789/11988.
Full textMade available in DSpace on 2015-03-11T17:43:47Z (GMT). No. of bitstreams: 2 Dissertação Filipe Carlos De Albuquerque Calegario.pdf: 5927675 bytes, checksum: 052e513854d4c99d80c0dd6f9fd70177 (MD5) license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Previous issue date: 2013-02-22
Novas interfaces estão mudando a forma como interagimos com as máquinas e isto é particularmente importante para o campo da música. Estas novas tecnologias abrem um grande leque de possibilidades para a criação de Instrumentos Musicais Digitais (DMIs), que são sistemas compostos por módulo de entrada, módulo de saída e uma estratégia de mapeamento conectando tais módulos. Ao contrário dos instrumentos acústicos, que impõem restrições físicas à sua fabricação, os DMIs permitem uma maior liberdade na sua construção. Paradoxalmente, esta vantagem pode se tornar um problema, pois não existem métodos ou ferramentas para guiar o designer ou luthier na definição de qual mapeamento é mais adequado entre entradas e saídas de um DMI. Seguindo a definição que o usuário é a força motriz da inovação e que a tendência do Movimento Maker mostra que, atualmente, tal usuário não é apenas um consumidor passivo de produtos, por que não fornecer aos músicos e artistas o poder de definir suas próprias estratégias de mapeamento e assim construir seu DMI? Neste contexto, a prototipação, conceito bastante importante no Design, se mostra como uma possível solução para o problema do mapeamento, permitindo que os usuários possam experimentar a adequação de entradas, saídas e mapeamentos diversos na criação de seu próprio DMI. Alguns sistemas musicais já permitem prototipação de DMIs (ex.: Pure Data, Max/MSP, Chuck, SuperCollider etc.), porém a maioria ainda precisa de um alto nível técnico para se chegar a um resultado não trivial. Este Projeto apresenta o Sketchument, um ambiente de experimentação de fácil utilização, voltado para o público não técnico, que permite que o usuário prototipe e crie DMIs, usando múltiplas entradas, saídas e mapeamentos. De protótipos de baixa fidelidade a protótipos funcionais, passando por avaliações por questionário e entrevista, o Sketchument tem sido desenvolvido seguindo a mesma filosofia de prototipação que ele se propõe a prover. O processo cíclico de concepção, implementação e avaliação tem produzido importantes resultados a partir dos potenciais usuários, que são bastante úteis para dar suporte às decisões de projeto e, assim, permitir modificações e melhoramentos.
Mugnaini, Irene. "Recupero dei metalli preziosi dai reflui di lavorazione dell'impianto UNOAERRE: modalità, problematiche e alternative." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2017.
Find full textMagi, Matteo. "Gestione del magazzino, codifica e tracciabilità dei prodotti di acquisto: il caso DMM S.p.A." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2021.
Find full textMusuraca, Gerardo <1976>. "Nuovi approcci terapeutici nel trattamento dei linfomi non hodgkin di derivazione dai linfociti T periferici." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/2081/1/Gerardo_Musuraca_tesi.pdf.
Full textMusuraca, Gerardo <1976>. "Nuovi approcci terapeutici nel trattamento dei linfomi non hodgkin di derivazione dai linfociti T periferici." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/2081/.
Full textLoddo, Giuseppe <1985>. "Dai risvegli confusi al sonnambulismo: aspetti clinici, videopolisonnografici e diagnosi differenziale dei disturbi dell'arousal nell'adulto." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amsdottorato.unibo.it/9146/1/Loddo%C2%AD_Giuseppe_Doa%C2%AD.pdf.
Full textIntroduction Arousal Disorders (DOA) include Confusional Arousal, Sleepwalking and Sleep Terrors. Adult DOA do not seem to be harmless, as in childhood, and need to be differentiated from other sleep disorders such as Sleep Hypermotor Epilepsy (SHE) in which seizures have an increasing intensity and duration ranging from paroxysmal arousal to hyperkinetic seizures and epileptic nocturnal wandering. Objectives To describe the clinical and semeiological features of DOA in adulthood; to characterize the motor features of the episodes in order to identify key features that can assist in the differential diagnosis with SHE. Methods The study involved adult DOA and SHE patients and healthy subjects who underwent a full-night videopolysomnography (VPSG). All VPSGs were analyzed by 2 neurologists with experience in sleep disorders and epilepsy who identified all movements and episodes arising from sleep. Results Sixty DOA, 30 SHE patients, and 15 healthy subjects have been enrolled. A total of 114 VPSG have been analyzed, 334 DOA and 140 paroxysmal arousals have been recorded. Three semeiological motor patterns with increasing intensity and complexity have been identified: simple arousal movements, rising arousal movements and complex arousal with ambulatory movements. Duration, sleep stage at onset, limb involvement, movement progression and behaviours are different in the briefest episodes of SHE and DOA. Episodes occurred mostly during N3 and N2 NREM sleep stage in DOA and SHE patients respectively. Conclusions The study described clinical and semeiological features of DOA in adulthood identifying key features that can assist in the differential diagnosis with SHE.
Angelini, Virginia. "Studio e modellizzazione delle accelerazioni non gravitazionali di Cassini causate dai getti dei geyser di Encelado." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/14262/.
Full textBaldassarra, Damiana <1974>. "Dai "Messenioi Andres" alla "Polis Ton Messenion": il percorso storico dei Messeni tra continuità e innovazione." Doctoral thesis, Università Ca' Foscari Venezia, 2006. http://hdl.handle.net/10579/681.
Full textGarbossa, Sefora <1995>. "Quando l'arte ispira l’alta moda, l'intreccio dai fashion studies alle creazioni artistiche dei brand di lusso." Master's Degree Thesis, Università Ca' Foscari Venezia, 2020. http://hdl.handle.net/10579/17422.
Full textRomeo, Vincenzo. "Brain involvement in myotonic dystrophies." Doctoral thesis, Università degli studi di Padova, 2009. http://hdl.handle.net/11577/3426050.
Full textScopo. Determinare il grado di coinvolgimento cerebrale in una coorte di pazienti DM1 ed una di DM2, mediante indagini cerebrali strumentali e test funzionali; confrontare i risultati dei due gruppi. Background: le distrofie miotoniche di tipo 1 e di tipo 2 (DM1, DM2) sono disordini multisistemici dovuti ad espansioni polinucleotidiche. Studi di imaging cerebrale e metodi funzionali hanno condotto a risultati contraddittori. Materiali e metodi: sono stati reclutati 50 DM1 e 14 DM2 molecolarmente definiti. Sono state registrate l’età al reclutamento, all’esordio, durata di malattia e scolarità. E’ stata fatta una valutazione neuromuscolare con la scala MIRS. Una ampia batteria neuropsicologica è stata somministrata a 48/50 DM1 e ad un gruppo di controllo di 44 soggetti sani. 46/50 DM1 e 12/14 DM2 sono stati sottoposti a RMN cerebrale; 21/50 DM1 e 9/14 DM2 sono stati sottoposti a SPECT cerebrale di perfusione, con analisi semiquantitativa dei risultati. Le immagini RMN sono state classificate con la scala ARWMC (age related white matter changes), al fine di quantificare ricorrenza, localizzazione, patterns di distribuzione delle lesioni iperintense della sostanza bianca (WMHLs) nelle nostre due coorti. I risultati della RMN sono stati appaiati ai risultati della SPECT e dei test neuropsicologici. Risultati: 37/46 DM1 e 10/12 DM2 avevano una RMN anormale, con WMHLs sparse sopratentoriali, bilaterali, simmetriche, focali o diffuse. Un tipico pattern diffuso sottocorticale temporoinsulare è stato osservato solo nella DM1, senza correlazione con il coinvolgimento cognitivo. Una maggiore compromissione cognitiva è stat osservata in caso di estese alterazioni frontali. Una relazione tra l’espansione nucleotidica CTG è stata documentata nella DM1. La SPECT ha mostrato una minima ipoperfusione a livello dei piani corticali posteriori nella DM1 e, in minor grado, nella DM2. E’ stato documentato un grado molto lieve di coinvolgimento cerebrale nella coorte DM2. Conclusioni: l’imaging cerebrale e le indagini funzionali hanno confermato un coinvolgimento più severo nella DM1 rispetto alla DM2. Un pattern lesionale diffuso temporo-insulare, specifico in caso di DM1, è stato documentato in RMN. Si conferma che a maggior grado di espansione nucleotidica corrisponde un maggior grado di coinvolgimento cerebrale nella DM1.
Chohan, Zahid H. "Co-ordination chemistry of the 1,3-dithiole-2-thione (DMIT) and 2-one-4,5-dithiolato (DMIO) compounds." Thesis, University of Aberdeen, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244990.
Full textAjaltouni, Ziad. "Etude de la physique photon-photon avec le détecteur magnétique DM2 au DCI, recherche des mésons scalaires." Grenoble 2 : ANRT, 1986. http://catalogue.bnf.fr/ark:/12148/cb37595492v.
Full textAjaltouni, Ziad. "Étude de la physique photon-photon avec le détecteur magnétique du DM2 au DCI : recherche des mésons scalaires." Clermont-Ferrand 2, 1986. http://www.theses.fr/1986CLF2E369.
Full textCorsi, Corrado. "Dai metodi contabili alla concettualizzazione dei sistemi: il paradosso dell'English system of book-keeping di Edward Thomas Jones." Doctoral thesis, Università Ca' Foscari Venezia, 2002. http://hdl.handle.net/10579/746.
Full textTavasci, Luca <1986>. "Il monitoraggio dei sistemi di riferimento terrestri mediante tecniche satellitari GNSS: dai sistemi globali ai servizi di posizionamento NRTK." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7591/1/Tesi_dottorato_Luca_Tavasci.pdf.
Full textThe geodetic reference systems, and the related frames, constitute the basic structure that allows to compare geometric representations of the earth acquired by different surveys. The last century has seen a continuous evolution in the definition of geodetic frames, mainly due to new needs, and possibilities, introduced by the space geodesy techniques. Are changed the scale of the problem, the precision of the measurements and the required accuracies, and also the approaches and definitions. The requirement of a global reference system has imposed the definition of dynamic frames, which follow the evolution of the earth's crust as a whole, so the need for introducing a time coordinate in addition to usual geometric coordinates. The dynamic nature of the Earth involves variations in time of coordinates, when expressed in the global reference system, too quick to be handled in mapping applications on a continental / national scale. So it was necessary the definition of other reference systems, linked to the tectonic plates. Thus, fundamental are the transformation parameters needed to switch from regional systems to global systems, and vice versa. In this thesis the topic of the monitoring of dynamic reference frames has been addressed, in particular the Italian Rete Dinamica Nazionale. The matter of the high residual ETRS velocities that characterize the Italian peninsula has been addressed, and a new ad hoc reference system was defined. The calculation technique of Precise Point Positioning has been investigated, both from the geodetic point of view, addressing the strategies to align the coordinates in the global system, than from the point of view of technical surveys. Finally, the geodetic networks of the Emilia-Romagna Region were analyzed, evaluating their importance in the age of GNSS.
Tavasci, Luca <1986>. "Il monitoraggio dei sistemi di riferimento terrestri mediante tecniche satellitari GNSS: dai sistemi globali ai servizi di posizionamento NRTK." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7591/.
Full textThe geodetic reference systems, and the related frames, constitute the basic structure that allows to compare geometric representations of the earth acquired by different surveys. The last century has seen a continuous evolution in the definition of geodetic frames, mainly due to new needs, and possibilities, introduced by the space geodesy techniques. Are changed the scale of the problem, the precision of the measurements and the required accuracies, and also the approaches and definitions. The requirement of a global reference system has imposed the definition of dynamic frames, which follow the evolution of the earth's crust as a whole, so the need for introducing a time coordinate in addition to usual geometric coordinates. The dynamic nature of the Earth involves variations in time of coordinates, when expressed in the global reference system, too quick to be handled in mapping applications on a continental / national scale. So it was necessary the definition of other reference systems, linked to the tectonic plates. Thus, fundamental are the transformation parameters needed to switch from regional systems to global systems, and vice versa. In this thesis the topic of the monitoring of dynamic reference frames has been addressed, in particular the Italian Rete Dinamica Nazionale. The matter of the high residual ETRS velocities that characterize the Italian peninsula has been addressed, and a new ad hoc reference system was defined. The calculation technique of Precise Point Positioning has been investigated, both from the geodetic point of view, addressing the strategies to align the coordinates in the global system, than from the point of view of technical surveys. Finally, the geodetic networks of the Emilia-Romagna Region were analyzed, evaluating their importance in the age of GNSS.
Bono, Sofia <1997>. "Culto ancestrale e ritualità nella Cina antica: dai culti primitivi neolitici al ritualismo dei Zhou Occidentali (1045-771 a.C.)." Master's Degree Thesis, Università Ca' Foscari Venezia, 2021. http://hdl.handle.net/10579/19978.
Full textZanette, Caterina. "Caratterizzazione dei meccanismi neuroprotettivi della guanosina e dei ligandi dei recettori sigma." Doctoral thesis, Università degli studi di Trieste, 2009. http://hdl.handle.net/10077/3044.
Full textRispetto al ruolo svolto da nucleosidi e nucleotidi adeninici come neurotrasmettitori/neuromodulatori, quello delle purine a base guaninica è ancora largamente sconosciuto. In questo studio, è stato valutato l’effetto della guanosina sulle cellule SH-SY5Y, derivate da un neuroblastoma umano. In questa linea cellulare, la guanosina aumenta la proliferazione di cellule sottoposte a stress da deprivazione da siero per 24, 48 e 72h (MTT test), effetto che sembra coinvolgere la via delle MAPK e quella di PI3K, ma non quella dell’AMP ciclico (AMPc). Utilizzando [3H]Adenosina e [3H]Guanosina è stato dimostrato che entrambe le purine subiscono uptake con una cinetica sovrapponibile ma con affinità 100 volte minore per la guanosina rispetto all’adenosina. L’uptake è dovuto principalmente a trasportatori equilibrativi NBTI-sensibili, mentre risultano assenti i trasportatori concentrativi. Mediante esperimenti di binding su membrane di cellule SH-SY5Y è stata confermata la presenza di siti per [3H]NBTI saturabili e reversibili; esperimenti di competizione hanno confermato la capacità di guanosina e adenosina di spiazzare [3H]NBTI dai suoi siti di legame con IC50 pari a 1568 ± 243 µM e 191 ± 59 µM, rispettivamente. Su cellule mantenute al 10% di siero, la guanosina provoca variazioni morfologiche quali allungamento dei neuriti tempo- e concentrazione-dipendente, indice di differenziazione. L’effetto è visibile già dopo 24 h di trattamento e dopo 72 h è risultato paragonabile a quello dell’acido retinoico. L’effetto differenziante della guanosina è risultato indipendente dal blocco dei trasportatori NBTI-sensibili e dall’attivazione dei recettori A1 e A2A dell’adenosina. Studi di tempo-dipendenza fino a 7 giorni di trattamento sono stati effettuati mediante colorazione del citoscheletro con Falloidina. Studi di immunocitochimica hanno evidenziato la capacità della guanosina di aumentare in maniera tempo-dipendente l’espressione dei markers neuronali beta-tubulina, MAP2 e NeuN. Tramite test della sulforodamina B è stata verificata la capacità della guanosina di ridurre in maniera tempo- e concentrazione-dipendente la proliferazione cellulare, come conseguenza dell’effetto differenziante. Dopo 7 giorni di trattamento, acido retinoico, guanosina e il suo derivato guanina hanno determinato una riduzione della proliferazione con valori di IC50 pari a 37 ± 4 µM, 172 ± 113 µM e 190 ± 17 µM, rispettivamente. Non essendoci in letteratura dati riguardanti la presenza dell’enzima PNP su cellule di neuroblastoma, ne è stata accertata l’espressione nella linea cellulare SH-SY5Y tramite RT-PCR. Per quanto riguarda le vie di trasduzione del segnale attivate nell’effetto neuritogenico indotto da guanosina, prove dirette e indirette dimostrano il coinvolgimento della via di MAPK e PI3K, ma non del AMPc. Inoltre, la guanosina non determina variazioni dei livelli di [Ca+2]i. In cellule differenziate per 48h con guanosina o acido retinoico si è osservato un aumento significativo dei livelli basali di AMPc, rispetto alle cellule non differenziate, e un potenziamento dell’attività dell’inibitore delle fosfodiesterasi di tipo IV rolipram da parte della guanosina 100 µM. In conclusione, questi risultati dimostrano che la guanosina gioca un ruolo importante nell’omeostasi neuronale, agendo come un composto endogeno neuroprotettivo e differenziante. In collaborazione con il Dipartimento di Chimica Farmaceutica dell’Ateneo e dell’Università degli Studi di Pavia è stato fatto uno screening mediante la tecnica del Radioligand Binding di circa 100 composti di neosintesi con possibile affinità verso i recettori sigma-1 e sigma-2, classe di recettori coinvolta nella neuroprotezione. Per valutare l’efficacia dei ligandi dei recettori sigma-1, in termini di agonismo o antagonismo, sono stati effettuati due test in vitro. Il primo sfrutta la capacità della fenitoina di spostare verso sinistra la curva di competizione di agonisti mentre non ha alcun effetto sugli antagonisti. I risultati ottenuti non sono stati incoraggianti a causa della scarsa sensibilità del metodo. Il secondo test sfrutta la capacità di agonisti dei recettori sigma-1 di differenziare le cellule SH-SY5Y nelle quali abbiamo verificato la presenza di entrambi i sottotipi recettoriali ottenendo valori di Kd pari a 19,8 ± 5 nM e 17,9 ± 3 nM per [3H]PTZ e [3H]DTG, rispettivamente. L’agonista pentazocina è risultato l’unico composto di riferimento in grado di indurre differenziazione mentre gli antagonisti aloperidolo e DTG sono risultati inefficaci. Con il test della Sulforodamina B, sempre sfruttando la diminuzione della proliferazione come conseguenza di un’attività differenziante, abbiamo confermato che solo la pentazocina è in grado di ridurre in maniera tempo- e concentrazione- dipendente la proliferazione cellulare con un valore di IC50 a 72 h pari a 44 ± 4 µM. Estendendo lo studio ad alcuni dei ligandi di neosintesi, quello maggiormente affine e selettivo, LEk (IC50s1 0,104 ± 0,034 nM; IC50s2 492 ± 102 nM), è risultato in grado di mimare l’effetto della pentazocina sulla proliferazione e differenziazione cellulare. Questo suggerisce un suo possibile e prezioso impiego come agonista altamente selettivo e ad alta affinità per lo studio dei recettori sigma-1 e dei potenziali impieghi terapeutici ad essi correlati.
XXI Ciclo
1979
Scarfò, Lucia. "Equilibrio dei fili e dei sistemi articolati." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amslaurea.unibo.it/5175/.
Full textCUOCO, CLAUDIA. "La tutela giurisdizionale dei diritti dei detenuti." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2005. http://hdl.handle.net/2108/202217.
Full textThe research talks about the matter of the effectiveness of the prisoners’ rights in the Italian rules and regulations. It starts listing the positions that have a punctual protection due to their positive recognition in the criminal laws and in the Constitution, as well as in the international treaties. Then it tells about the stages of the evolution -from an administrative to a jurisdictional conception- in the executive phase of a criminal trial, highlighting the current lacks of warranties. It refers, particularly, to the opinion of the Italian Supreme Court (verdict n. 26/1999) about the incompleteness of the in force jurisdictional system about prisoners’ rights protection. At last, no measures adopted by the Italian parliament since the judges’ reprimand, it tries to build up the co-ordinates of a positive warranty system, respectful of the jurisdictional parameter, by illustrating the position of jurists and the experience of the Courts, which both, in the last years, are trying to test practical solutions in order to ensure effective rights to prisoners.
D'Aiello, Grazia Maria. "La disciplina concorsuale dei finanziamenti dei soci." Doctoral thesis, Università di Catania, 2014. http://hdl.handle.net/10761/1579.
Full textNatali, Karma <1986>. "La Tutela giurisdizionale dei diritti dei detenuti." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7718/1/Natali_Karma_Tesi.pdf.
Full textAim of the present paper is to analyze the recent developments on the subject of the protection of the rights of the detained persons resulting from the recent innovations brought by the d.l. December 23rd, 2013, n°146 (converted into Law February 21st, 2014, n° 10). There is little doubt the main topic is the “jurisdictional complaint”, a long-awaited yet controversial tool with a troublesome task: settling the order’s jurisdictional debt towards the rights of the detained persons. There are two different perspectives to this analysis. The first part will pinpoint the juridical positions protected by the remedy displayed by the conjunction of artt. 35-bis and 69 clause ord. penit, while part number two will analyze the dynamic aspect: we will move from the inquiry on the complaint’s object to the process by which both detained and interned persons may employ it. The result is but the screenshot of a system heavily wounded by the backlash of years of clumsy penitentiary politics and absence of an aware legislator. In this condition, this very system can only find in the supranational authorities its true drive towards the progress of the rights of the detained persons.
Takala, Martti. "Lex Dei-- Lex politica Dei Lex politica Dei -teos ja Kaarle IX:n lainsäädäntö /." Helsinki : SKHS : SHS, 1993. http://catalog.hathitrust.org/api/volumes/oclc/29333877.html.
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