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Journal articles on the topic 'DMDPR'

Author: Grafiati

Published: 4 June 2021

Last updated: 4 February 2022

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1

Suling, William J., Lainne E. Seitz, Vibha Pathak, Louise Westbrook, Esther W. Barrow, Sabrina Zywno-van-Ginkel, Robert C. Reynolds, J. Robert Piper, and William W. Barrow. "Antimycobacterial Activities of 2,4-Diamino-5-Deazapteridine Derivatives and Effects on Mycobacterial Dihydrofolate Reductase." Antimicrobial Agents and Chemotherapy 44, no. 10 (October 1, 2000): 2784–93. http://dx.doi.org/10.1128/aac.44.10.2784-2793.2000.

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ABSTRACT Development of new antimycobacterial agents for Mycobacterium avium complex (MAC) infections is important particularly for persons coinfected with human immunodeficiency virus. The objectives of this study were to evaluate the in vitro activity of 2,4-diamino-5-methyl-5-deazapteridines (DMDPs) against MAC and to assess their activities against MAC dihydrofolate reductase recombinant enzyme (rDHFR). Seventy-seven DMDP derivatives were evaluated initially for in vitro activity against one to three strains of MAC (NJ168, NJ211, and/or NJ3404). MICs were determined with 10-fold dilutions of drug and a colorimetric (Alamar Blue) microdilution broth assay. MAC rDHFR 50% inhibitory concentrations versus those of human rDHFR were also determined. Substitutions at position 5 of the pteridine moiety included -CH3, -CH2CH3, and -CH2OCH3 groups. Additionally, different substituted and unsubstituted aryl groups were linked at position 6 through a two-atom bridge of either -CH2NH, -CH2N(CH3), -CH2CH2, or -CH2S. All but 4 of the 77 derivatives were active against MAC NJ168 at concentrations of ≤13 μg/ml. Depending on the MAC strain used, 81 to 87% had MICs of ≤1.3 μg/ml. Twenty-one derivatives were >100-fold more active against MAC rDHFR than against human rDHFR. In general, selectivity was dependent on the composition of the two-atom bridge at position 6 and the attached aryl group with substitutions at the 2′ and 5′ positions on the phenyl ring. Using this assessment, a rational synthetic approach was implemented that resulted in a DMDP derivative that had significant intracellular activity against a MAC-infected Mono Mac 6 monocytic cell line. These results demonstrate that it is possible to synthesize pteridine derivatives that have selective activity against MAC.

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2

Глотова (Glotova), Ирина (Irina) Анатольевна (Anatol'evna), and Надежда (Nadezhda) Алексеевна (Alekseevna) Галочкина (Galochkina). "INFLUENCE OF SOURCES OF SELENIUM ON BIOCHEMICAL PROCESSES DURING SWELLING AND GERMINATION OF WHEAT GRAIN." chemistry of plant raw material, no. 4 (June 2, 2017): 211–16. http://dx.doi.org/10.14258/jcprm.2017041849.

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The influence of sodium selenite and 4,4-di[3(5-methylpiperazine)]selenide (DMDPS) on microphenological phases of swelling and germination of grain of winter wheat of a grade "Alaya Zarya" was studied. The influence of sodium selenite and DMDPS on amylolytic, proteolytic activity and contents in the form of glutathione is studied. Opposite action of DMDPS and selenit on biochemical processes at grain germination is found: for DMDPS – stimulating, for sodium selenit – depressant. Under the influence of sodium selenit the decrease in proteolytic activity by 30%, under the influence of DMDPS – 5% is revealed. It is found that amylolytic activity of wheat under the influence of DMDPS shows a tendency to achieve the same level, as in the control "Wheat + H2O", however the maximum is reached 4 hours earlier. In a sample with sodium selenit the decrease in amylolytic activity by 15% in comparison with control is found. Stimulating action of DMDPS on glutathione accumulation is detected. The maximum contents in the form of glutathione is noted for a sample of wheat, germinated with DMDPS – 8,53 mg%. It is 22,6% more than in the control sample, and is 36,1% more, than in the sample with sodium selenit. The extreme values of an indicator are reached in 28 hours of germination for the control sample, in 16–20 hours – for samples with DMDPS and Na2SeO3. The duration of microphenological phases of germination of seeds using DMDPS as a part of steep water is reduced by 2–4 hours in comparison with tap water. The results are used for control of wheat grain germination in the process of additives enriched with selenium on grain basis.

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3

Wise, Arlene A., and Cheryl R. Kuske. "Generation of Novel Bacterial Regulatory Proteins That Detect Priority Pollutant Phenols." Applied and Environmental Microbiology 66, no. 1 (January 1, 2000): 163–69. http://dx.doi.org/10.1128/aem.66.1.163-169.2000.

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ABSTRACT The genetic systems of bacteria that have the ability to use organic pollutants as carbon and energy sources can be adapted to create bacterial biosensors for the detection of industrial pollution. The creation of bacterial biosensors is hampered by a lack of information about the genetic systems that control production of bacterial enzymes that metabolize pollutants. We have attempted to overcome this problem through modification of DmpR, a regulatory protein for the phenol degradation pathway of Pseudomonassp. strain CF600. The phenol detection capacity of DmpR was altered by using mutagenic PCR targeted to the DmpR sensor domain. DmpR mutants were identified that both increased sensitivity to the phenolic effectors of wild-type DmpR and increased the range of molecules detected. The phenol detection characteristics of seven DmpR mutants were demonstrated through their ability to activate transcription of alacZ reporter gene. Effectors of the DmpR derivatives included phenol, 2-chlorophenol, 2,4-dichlorophenol, 4-chloro-3-methylphenol, 2,4-dimethylphenol, 2-nitrophenol, and 4-nitrophenol.

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4

Sarand, Inga, Eleonore Skärfstad, Mats Forsman, Martin Romantschuk, and Victoria Shingler. "Role of the DmpR-Mediated Regulatory Circuit in Bacterial Biodegradation Properties in Methylphenol-Amended Soils." Applied and Environmental Microbiology 67, no. 1 (January 1, 2001): 162–71. http://dx.doi.org/10.1128/aem.67.1.162-171.2001.

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ABSTRACT Pathway substrates and some structural analogues directly activate the regulatory protein DmpR to promote transcription of thedmp operon genes encoding the (methyl)phenol degradative pathway of Pseudomonas sp. strain CF600. While a wide range of phenols can activate DmpR, the location and nature of substituents on the basic phenolic ring can limit the level of activation and thus utilization of some compounds as assessed by growth on plates. Here we address the role of the aromatic effector response of DmpR in determining degradative properties in two soil matrices that provide different nutritional conditions. Using the wild-type system and an isogenic counterpart containing a DmpR mutant with enhanced ability to respond to para-substituted phenols, we demonstrate (i) that the enhanced in vitro biodegradative capacity of the regulator mutant strain is manifested in the two different soil types and (ii) that exposure of the wild-type strain to 4-methylphenol-contaminated soil led to rapid selection of a subpopulation exhibiting enhanced capacities to degrade the compound. Genetic and functional analyses of 10 of these derivatives demonstrated that all harbored a single mutation in the sensory domain of DmpR that mediated the phenotype in each case. These findings establish a dominating role for the aromatic effector response of DmpR in determining degradation properties. Moreover, the results indicate that the ability to rapidly adapt regulator properties to different profiles of polluting compounds may underlie the evolutionary success of DmpR-like regulators in controlling aromatic catabolic pathways.

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5

Watson, Alison A., Ana L. Winters, Sarah A. Corbet, Catherine Tiley, and Robert J. Nash. "Selective Metabolism of Glycosidase Inhibitors by a Specialized Moth Feeding on Hyacinthoides non-scripta Flowers." Natural Product Communications 3, no. 1 (January 2008): 1934578X0800300. http://dx.doi.org/10.1177/1934578x0800300109.

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The British moth Eana incanana (Tortricidae) has been found to selectively metabolize the glycosidase inhibitor 2 R, 3 R, 4 R, 5 R-2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine (DMDP), whereas it excretes related alkaloids from Hyacinthoides non-scripta (Hyacinthaceae). Very few native animals feed on H. non-scripta, but the larvae of E. incanana are specialized herbivores feeding just on the buds and flowers destroying the ovary. DMDP is the major glucosidase inhibitor of H. non-scripta and the moth may overcome inhibition of digestive glucosidases by metabolizing the DMDP. The glucosidase enzymes of the caterpillar are inhibited by DMDP. The caterpillar excretes the other glycosidase inhibitors produced by this plant and the frass has increased concentrations of these alkaloids.

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6

Shaban, Samy, Abd Elaziz Fouda, Mohamed Elmorsi, Tarek Fayed, and Omar Azazy. "A study on the effect of new prepared amide cationic amphipathic on the corrosion inhibition of API N80 steel pipelines in oil wells industries." Anti-Corrosion Methods and Materials 65, no. 2 (March 5, 2018): 197–209. http://dx.doi.org/10.1108/acmm-08-2017-1824.

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Purpose The purpose of this study is to inspect the corrosion inhibition of API N80 steel pipelines in uninhibited solution and inhibited with a synthesized surfactant compound [N-(3-(dimethyl octyl ammonio) propyl) palmitamide bromide] (DMDPP), which is prepared through a simple and applicable method. Design/methodology/approach Weight loss was inspected at five different temperatures of 25°C, 30°C, 40°C, 50°C and 60°C Potentiodynamic polarization, electrochemical impedance spectroscopy (EIS) and electrochemical frequency modulation were used at room temperature. Density functional theory was used to study the relation between the molecular structure and inhibition theoretically. Findings Adsorption of the prepared DMDPP fits the Langmuir isotherm model. The inhibition efficiency of the prepared DMDPP amphipathic inhibitor is directly proportional to temperature increase. Polarization results reveal that the investigated DMDPP amphipathic compound behaves as a mixed-type inhibitor. EIS spectra produced one individual capacitive loop. Originality/value The originality is the preparation of cationic surfactants through a simple method, which can be used as corrosion inhibitors in oil production. The synthesized inhibitors were prepared from low-price materials. The work studied the behavior of the synthesized surfactants in inhibiting the corrosion of the steel in an acidic medium. Electrochemical and theoretical studies were presented, besides gravimetric and surface examination.

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7

Skärfstad, Eleonore, Eric O'Neill, Junkal Garmendia, and Victoria Shingler. "Identification of an Effector Specificity Subregion within the Aromatic-Responsive Regulators DmpR and XylR by DNA Shuffling." Journal of Bacteriology 182, no. 11 (June 1, 2000): 3008–16. http://dx.doi.org/10.1128/jb.182.11.3008-3016.2000.

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ABSTRACT The Pseudomonas derived ς54-dependent regulators DmpR and XylR control the expression of genes involved in catabolism of aromatic compounds. Binding to distinct, nonoverlapping groups of aromatic effectors controls the activities of these transcriptional activators. Previous work has derived a common mechanistic model for these two regulators in which effector binding by the N-terminal 210 residues (the A-domain) of the protein relieves repression of an intrinsic ATPase activity essential for its transcription-promoting property and allows productive interaction with the transcriptional apparatus. Here we dissect the A-domains of DmpR and XylR by DNA shuffling to identify the region(s) that mediates the differences in the effector specificity profiles. Analysis of in vivo transcription in response to multiple aromatic effectors and the in vitro phenol-binding abilities of regulator derivatives with hybrid DmpR/XylR A-domains reveals that residues 110 to 186 are key determinants that distinguish the effector profiles of DmpR and XylR. Moreover, the properties of some mosaic DmpR/XylR derivatives reveal that high-affinity aromatic effector binding can be completely uncoupled from the ability to promote transcription. Hence, novel aromatic binding properties will only be translated into functional transcriptional activation if effector binding also triggers release of interdomain repression.

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8

Yamashita, Cory, Amy Forbes, Jenna M. Tessolini, Li-Juan Yao, James F. Lewis, and Ruud A. W. Veldhuizen. "Protective effects of elevated endogenous surfactant pools to injurious mechanical ventilation." American Journal of Physiology-Lung Cellular and Molecular Physiology 294, no. 4 (April 2008): L724—L732. http://dx.doi.org/10.1152/ajplung.00389.2007.

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Depletion of alveolar macrophages (AM) leads to an increase in endogenous surfactant that lasts several days beyond the repletion of AM. Furthermore, impairment to the endogenous pulmonary surfactant system contributes to ventilation-induced lung injury. The objective of the current study was to determine whether increased endogenous surfactant pools induced via AM depletion was protective against ventilation-induced lung injury. Adult rats were intratracheally instilled with either control or dichloromethylene diphosphonic acid (DMDP) containing liposomes to deplete AMs and thereby increase endogenous surfactant pools. Either 3 or 7 days following instillation, rats were exposed to 2 h of injurious ventilation using either an ex vivo or in vivo ventilation protocol and were compared with nonventilated controls. The measured outcomes were oxygenation, lung compliance, lavage protein, and inflammatory cytokine concentrations. Compared with controls, the DMDP-treated animals had significantly reduced AM numbers and increased surfactant pools 3 days after instillation. Seven days after instillation, AM numbers had returned to normal, but surfactant pools were still elevated. DMDP-treated animals at both time points exhibited protection against ventilation-induced lung injury, which included superior physiological parameters, lower protein leakage, and lower inflammatory mediator release into the air space, compared with animals not receiving DMDP. It is concluded that DMDP-liposome administration protects against ventilation-induced lung injury. This effect appears to be due to the presence of elevated endogenous surfactant pools.

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9

Hamui, Leon, and María Elena Sánchez-Vergara. "Innovative Implementation of an Alternative Tetrathiafulvene Derivative for Flexible Indium Phthalocyanine Chloride-Based Solar Cells." Micromachines 12, no. 6 (May 29, 2021): 633. http://dx.doi.org/10.3390/mi12060633.

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Herein, we present the photovoltaic properties of an indium phthalocyanine chloride (InClPc)-based flexible planar heterojunction device, introducing the tetrathiafulvene derivative 4,4′-Dimethyl-5,5′-diphenyltetrathiafulvalene (DMDP-TTF) as the electron donor layer. UV-vis spectroscopy is widely used to characterize the electronic behavior of the InClPc/DMDP-TTF active layer. The interactions between the DMDP-TTF and phthalocyanine are predominantly intermolecular and the result of the aggregation of InClPc. Tauc bands were obtained at 1.41 and 2.8 eV; these energy peaks can result in a charge transfer ascribed to the transition from the DMDP-TTF to π-orbitals that are associated with the phthalocyanine ring or even with the same indium metal center. Conductive carbon (CC) was used for the cathode. Finally, an indium tin oxide (ITO)/InClPc/DMDP-TTF/CC device was fabricated by high-vacuum thermal evaporation onto a flexible substrate and the photovoltaic properties were evaluated. A diode type I-V curve behavior was observed with a photovoltaic response under illumination. A generated photocurrent of 2.25 × 10−2 A/cm2 was measured. A conductivity reduction with the incident photon energy from 1.61 × 10−7 S/cm to 1.43 × 10−7 S/cm is observed. The diode resistance presents two different behaviors with the applied voltage. A VTFL of 5.39 V, trap concentration of 7.74 × 1016 cm−3, and carrier mobility values of ~10−6 cm2/V s were calculated, showing improved characteristics via the innovative implementation of an alternative TTF-derivative, indicating that the DMDP-TTF has a strong interaction at the junction where free available states are increased, thus inducing higher mobilities due to the large number of π-orbitals, which indicates the feasibility of its use in solar cells technology.

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10

Forbes, Amy, Mike Pickell, Mehry Foroughian, Li-Juan Yao, James Lewis, and Ruud Veldhuizen. "Alveolar macrophage depletion is associated with increased surfactant pool sizes in adult rats." Journal of Applied Physiology 103, no. 2 (August 2007): 637–45. http://dx.doi.org/10.1152/japplphysiol.00995.2006.

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Pulmonary surfactant is a lipid-protein material that is essential for normal lung function. Maintaining normal and consistent alveolar amounts of surfactant is in part dependent on clearance of surfactant by alveolar macrophages (AM). The present study utilized a rat model of AM depletion to determine the impact on surfactant pool sizes and function over time. Male Sprague-Dawley rats were anesthetized and intratracheally instilled with PBS-liposomes (PBS-L) or dichloromethylene diphosphonic acid (DMDP) containing liposomes (DMDP-L) and were killed at various time points up to 21 days for compliance measurements, AM cell counts, and surfactant analysis. AM numbers were significantly decreased 1, 2, and 3 days after instillation in DMDP-L vs. PBS-L, with 72% depletion at 3 days. AM numbers returned to normal levels by 5 days. In DMDP-L rats, there was a rapid increase in surfactant-phospholipid pools, showing a ninefold increase in the amount of surfactant in the lavage 3 days after liposome instillation. Surfactant accumulation progressed up to 7 days, with pools normalizing by 21 days. The increase in surfactant was due to increases in both subfractions of surfactant, the large aggregates (LA) and small aggregates. Surfactant protein A levels, relative to LA phospholipids, were not increased. There was a decreased extent of surfactant conversion in vitro for LA from DMDP-L rats compared with controls. It is concluded that the procedure of AM depletion significantly affects surfactant metabolism. The increased endogenous surfactant must be considered when utilizing the AM depletion model to study the role of these cells during lung insults.

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Sze, Chun Chau, Lisandro M. D. Bernardo, and Victoria Shingler. "Integration of Global Regulation of Two Aromatic-Responsive σ54-Dependent Systems: a Common Phenotype by Different Mechanisms." Journal of Bacteriology 184, no. 3 (February 1, 2002): 760–70. http://dx.doi.org/10.1128/jb.184.3.760-770.2002.

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ABSTRACT Pseudomonas-derived regulators DmpR and XylR are structurally and mechanistically related σ54-dependent activators that control transcription of genes involved in catabolism of aromatic compounds. The binding of distinct sets of aromatic effectors to these regulatory proteins results in release of a repressive interdomain interaction and consequently allows the activators to promote transcription from their cognate target promoters. The DmpR-controlled Po promoter region and the XylR-controlled Pu promoter region are also similar, although homology is limited to three discrete DNA signatures for binding σ54 RNA polymerase, the integration host factor, and the regulator. These common properties allow cross-regulation of Pu and Po by DmpR and XylR in response to appropriate aromatic effectors. In vivo, transcription of both the DmpR/Po and XylR/Pu regulatory circuits is subject to dominant global regulation, which results in repression of transcription during growth in rich media. Here, we comparatively assess the contribution of (p)ppGpp, the FtsH protease, and a component of an alternative phosphoenolpyruvate-sugar phosphotransferase system, which have been independently implicated in mediating this level of regulation. Further, by exploiting the cross-regulatory abilities of these two circuits, we identify the target component(s) that are intercepted in each case. The results show that (i) contrary to previous speculation, FtsH is not universally required for transcription of σ54-dependent systems; (ii) the two factors found to impact the XylR/Pu regulatory circuit do not intercept the DmpR/Po circuit; and (iii) (p)ppGpp impacts the DmpR/Po system to a greater extent than the XylR/Pu system in both the native Pseudomonas putida and a heterologous Escherichia coli host. The data demonstrate that, despite the similarities of the specific regulatory circuits, the host global regulatory network latches onto and dominates over these specific circuits by exploiting their different properties. The mechanistic implications of how each of the host factors exerts its action are discussed.

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12

De Lena, Mario, Mario Brandi, Domenica Bozzi, Pietro Calabrese, and Sante Romito. "4-Demethoxydaunorubicin Administered Orally in Advanced Breast Cancer." Tumori Journal 74, no. 1 (February 1988): 65–70. http://dx.doi.org/10.1177/030089168807400111.

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Twenty-five patients with advanced breast cancer were treated with 4-demethoxydaunorubicin (4-DMDR), a new antitumor analogue of daunorubicin, at the dose of 15-20 mg/m2/day X 3 days by oral route every 3-4 weeks. All patients were previously treated with chemotherapy and/or hormone therapy but none with anfhracyclines. Of 23 evaluable patients, 1 complete and 5 partial remissions (26%) were observed for a median duration of 4+ months. Leukopenia and nausea occurred in 61% of the patients, vomiting in 30%, diarrhea in 17% and alopecia in 43%. There were 2 cases with minimal and transient EKG variations. 4-DMDR, administered orally in advanced breast cancer, was found to be generally well tolerated. Nevertheless, randomized trials with adriamycin or epirubicin are necessary to compare and to define the therapeutic activity and the toxicity of 4-DMDR.

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13

Liu, Tianjun, Jiawei Wang, Liang Wang, Jing Wang, Jingbo Lan, Jingsong You, and Chao Jiang. "Spiral growth mode in DMDPC organic thin film transistors by physical vapor deposition." RSC Advances 6, no. 56 (2016): 50770–75. http://dx.doi.org/10.1039/c6ra09711a.

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We report the observation of a screw-dislocation-driven spiral growth of DMDPC organic thin films. The existence of screw dislocations was clearly confirmed by the observations of outcropped stepsand spiral fringes.

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14

Ren, Junjie, Ping Guo, and Zhaoli Guo. "Rectangular Lattice Boltzmann Equation for Gaseous Microscale Flow." Advances in Applied Mathematics and Mechanics 8, no. 2 (April 2014): 306–30. http://dx.doi.org/10.4208/aamm.2014.m672.

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AbstractThe lattice Boltzmann equation (LBE) is considered as a promising approach for simulating flows of liquid and gas. Most of LBE studies have been devoted to regular square LBE and few works have focused on the rectangular LBE in the simulation of gaseous microscale flows. In fact, the rectangular LBE, as an alternative and efficient method, has some advantages over the square LBE in simulating flows with certain computational domains of large aspect ratio (e.g., long micro channels). Therefore, in this paper we expand the application scopes of the rectangular LBE to gaseous microscale flow. The kinetic boundary conditions for the rectangular LBE with a multiple-relaxation-time (MRT) collision operator, i.e., the combined bounce-back/specular-reflection (CBBSR) boundary condition and the discrete Maxwell's diffuse-reflection (DMDR) boundary condition, are studied in detail. We observe some discrete effects in both the CBBSR and DMDR boundary conditions for the rectangular LBE and present a reasonable approach to overcome these discrete effects in the two boundary conditions. It is found that the DMDR boundary condition for the square MRT-LBE can not realize the real fully diffusive boundary condition, while the DMDR boundary condition for the rectangular MRT-LBE with the grid aspect ratio a≠1 can do it well. Some numerical tests are implemented to validate the presented theoretical analysis. In addition, the computational efficiency and relative difference between the rectangular LBE and the square LBE are analyzed in detail. The rectangular LBE is found to be an efficient method for simulating the gaseous microscale flows in domains with large aspect ratios.

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15

Xu, Zeng, Jiabao Gu, Jian Huang, Chengwei Lin, Yuanzhao Li, Dezhi Yang, Xianfeng Qiao, et al. "Design and performance study of high efficiency/low efficiency roll-off/high CRI hybrid WOLEDs based on aggregation-induced emission materials as fluorescent emitters." Materials Chemistry Frontiers 3, no. 12 (2019): 2652–58. http://dx.doi.org/10.1039/c9qm00539k.

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16

Li, Yi-Xian, Kyoko Kinami, Yuki Hirokami, Atsushi Kato, Jia-Kun Su, Yue-Mei Jia, George W. J. Fleet, and Chu-Yi Yu. "Gem-difluoromethylated and trifluoromethylated derivatives of DMDP-related iminosugars: synthesis and glycosidase inhibition." Organic & Biomolecular Chemistry 14, no. 7 (2016): 2249–63. http://dx.doi.org/10.1039/c5ob02474a.

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17

Kato, Atsushi, Izumi Nakagome, Shinpei Nakagawa, Kyoko Kinami, Isao Adachi, Sarah F. Jenkinson, Jérôme Désiré, et al. "In silicoanalyses of essential interactions of iminosugars with the Hex A active site and evaluation of their pharmacological chaperone effects for Tay–Sachs disease." Organic & Biomolecular Chemistry 15, no. 44 (2017): 9297–304. http://dx.doi.org/10.1039/c7ob02281f.

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18

Deng, Xue-Mei. "Effects of a brane world on gravitational time advancement." Modern Physics Letters A 33, no. 19 (June 21, 2018): 1850110. http://dx.doi.org/10.1142/s0217732318501109.

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Solar System tests of a brane world, which is called DMPR model, were studied in recent works. The correction of DMPR model to the general relativity (GR) in the four-dimensional curved spacetime can be parametrized by a “tidal charge” parameter [Formula: see text]. The parameter [Formula: see text] in this model was obtained and improved as [Formula: see text] by the Earth–Mercury ranging. A new test of the DMPR model based on gravitational time advancement is proposed and investigated in this work. The advancement is a gravitational consequence on round-trip proper time duration of a photon. For ranging a distant spacecraft, it is shown that (1) the “tidal charge” parameter can make the advancement larger or smaller than the one of GR, depending on the sign of [Formula: see text]; (2) the superior conjunction (SC) and the inferior conjunction (IC) are all suitable for detecting the advancement; (3) the advancement can be complementary to the classical test of Shapiro time delay for detecting the brane world; and (4) the implementation of optical clocks and planetary laser ranging will provide more insights on the brane world model in the future.

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Lu, Katherine, Niramol Savaraj, John Kavanagh, Lynn G. Feun, Michael Burgess, Gerald P. Bodey, and Ti Li Loo. "Clinical pharmacology of 4-demethoxydaunorubicin (DMDR)." Cancer Chemotherapy and Pharmacology 17, no. 2 (June 1986): 143–48. http://dx.doi.org/10.1007/bf00306743.

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20

Sauer, U. H., J. Wolf, G. Stier, C. Grundström, and V. Shingler. "Transcriptional activator DmpR – combining biocrystallography and bioinformatics." Acta Crystallographica Section A Foundations of Crystallography 67, a1 (August 22, 2011): C633. http://dx.doi.org/10.1107/s010876731108398x.

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21

Jaspers, Marco C. M., Winfried A. Suske, Andreas Schmid, David A. M. Goslings, Hans-Peter E. Kohler, and Jan Roelof van der Meer. "HbpR, a New Member of the XylR/DmpR Subclass within the NtrC Family of Bacterial Transcriptional Activators, Regulates Expression of 2-Hydroxybiphenyl Metabolism in Pseudomonas azelaica HBP1." Journal of Bacteriology 182, no. 2 (January 15, 2000): 405–17. http://dx.doi.org/10.1128/jb.182.2.405-417.2000.

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ABSTRACT The regulation of 2-hydroxybiphenyl and 2,2′-dihydroxybiphenyl degradation in Pseudomonas azelaica is mediated by the regulatory gene, hbpR. The hbpR gene encodes a 63-kDa protein belonging to the NtrC family of prokaryotic transcriptional activators and having the highest homology to members of the XylR/DmpR subclass. Disruption of the hbpRgene in P. azelaica and complementation intrans showed that the HbpR protein was the key regulator for 2-hydroxybiphenyl metabolism. Induction experiments withP. azelaica and Escherichia coli containingluxAB-based transcriptional fusions revealed that HbpR activates transcription from a promoter (P hbpC ) in front of the first gene for 2-hydroxybiphenyl degradation, hbpC, and that 2-hydroxybiphenyl itself is the direct effector for HbpR-mediated activation. Of several compounds tested, only the pathway substrates 2-hydroxybiphenyl and 2,2′-dihydroxybiphenyl and structural analogs like 2-aminobiphenyl and 2-hydroxybiphenylmethane were effectors for HbpR activation. HbpR is therefore, to our knowledge, the first regulator of the XylR/DmpR class that recognizes biaromatic but not monoaromatic structures. Analysis of a spontaneously occurring mutant, P. azelaica HBP1 Prp, which can grow with the non-wild-type effector 2-propylphenol, revealed a single mutation in the hbpR gene (T613C) leading to a Trp→Arg substitution at amino acid residue 205.P. azelaica HBP1 derivative strains without a functional hbpR gene constitutively expressed the genes for 2-hydroxybiphenyl degradation when complemented in transwith the hbpR-T613C gene. This suggests the importance of this residue, which is conserved among all members of the XylR/DmpR subclass, for interdomain repression.

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Yu, Chu-Yi, Naoki Asano, Kyoko Ikeda, Mei-Xiang Wang, Terry D. Butters, Mark R. Wormald, Raymond A. Dwek, Ana L. Winters, Robert J. Nash, and George W. J. Fleet. "Looking glass inhibitors:l-DMDP, a more potent and specific inhibitor of α-glucosidases than the enantiomeric natural product DMDP." Chem. Commun., no. 17 (2004): 1936–37. http://dx.doi.org/10.1039/b406035k.

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23

Chang, Minwoo, and Marc Maguire. "Condition Rating Prediction Using an Interactive Deterioration Model Development Package." Applied Sciences 10, no. 24 (December 15, 2020): 8946. http://dx.doi.org/10.3390/app10248946.

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This paper presents an advanced method to determine explanatory variables required for developing deterioration models without the interference of human bias. Although a stationary set of explanatory variables is ideal for long-term monitoring and asset management, the penalty regression results vary annually due to the innate bias in the inspection data. In this study, weighting factors were introduced to consider the inspection data collected for several years, and the most stationary set was identified. To manage the substantial amount of inspection data effectively, we proposed a software package referred to as the Deterioration Model Development Package (DMDP). The objective of the DMDP is to provide a convenient platform for users to process and investigate bridge inspection data. Using the standardized data interpretation, the user can update an initial dataset for the deterioration model development when new inspection data are archived. The deterministic method and several stochastic approaches were included for the development of the deterioration models. The performances of the investigated methods were evaluated by estimating the error between the predicted and inspected condition ratings; further, this error was used for estimating the most effective number of explanatory variables for a given number of bridges.

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R, Ms Prema. "Efficient Data Management in Grid Computing using DMDR Algorithm." International Journal for Research in Applied Science and Engineering Technology 7, no. 3 (March 31, 2019): 1300–1304. http://dx.doi.org/10.22214/ijraset.2019.3236.

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Zhao, Yi, Yanyan Shen, and Yong Huang. "DMDP: A Dynamic Multi-source Default Probability Prediction Framework." Data Science and Engineering 4, no. 1 (March 2019): 3–13. http://dx.doi.org/10.1007/s41019-019-0085-9.

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Deng, Xue-Mei, and Yi Xie. "New upper limits of a braneworld model with recent Solar System tests." Modern Physics Letters A 31, no. 05 (February 5, 2016): 1650021. http://dx.doi.org/10.1142/s0217732316500218.

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As an extension of previous works on classical tests of a braneworld model which is called as the Dadhich, Maartens, Papadopoulos and Rezania (DMPR) solution, and as an attempt to find more stringent constraints on this model, we investigate its effects on physical experiments and astronomical observations conducted in the Solar System by modeling new observable effects and adopting new datasets. First, we investigate gravitational time delay at inferior conjunction (IC) caused by the braneworld model, which was not considered in previous works, because these measurements are not affected by the solar corona noise. Second, the Cassini superior conjunction (SC) experiment is, for the first time, used to test the DMPR model. Third, compared to previous works, we refine the model, which confronts the perihelion shift induced by the braneworld model with modern Solar System ephemerides INPOP10a (IMCCE, France) and EPM2011 (IAA RAS, Russia). The correction of DMPR solution to Einstein’s general relativity (GR) in the four-dimensional spacetime can be characterized by a constant bulk “tidal charge” parameter [Formula: see text], which is confined in the present work. We find that time delay experiment at IC is independent of [Formula: see text] and not suitable for testing the braneworld model. However, the Cassini SC experiment and modern Solar System ephemerides can give better upper bounds on [Formula: see text]: (1) [Formula: see text] by Cassini, and (2) [Formula: see text] based on the supplementary advances of the perihelia provided by INPOP10a and [Formula: see text] based on the ones of EPM2011. The latter upper bounds are improved to be tighter than the ones of previous works by at least two orders of magnitude. Besides, the stronger constraints on the brane tension are given by the modern ephemerides, which are [Formula: see text] for INPOP10a and [Formula: see text] for EPM2011. These improved upper bounds mean that the Solar System tests can serve as a good testbed for high dimensional theories.

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Best, Daniel, Chen Wang, Alexander C. Weymouth-Wilson, Robert A. Clarkson, Francis X. Wilson, Robert J. Nash, Saori Miyauchi, Atsushi Kato, and George W. J. Fleet. "Looking glass inhibitors: scalable syntheses of DNJ, DMDP, and (3R)-3-hydroxy-l-bulgecinine from d-glucuronolactone and of l-DNJ, l-DMDP, and (3S)-3-hydroxy-d-bulgecinine from l-glucuronolactone. DMDP inhibits β-glucosidases and β-galactosidases whereas l-DMDP is a potent and specific inhibitor of α-glucosidases." Tetrahedron: Asymmetry 21, no. 3 (March 2010): 311–19. http://dx.doi.org/10.1016/j.tetasy.2010.01.017.

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Srivastava, Vivek, Ashutosh Kumar, Bhartendu Nath Mishra, and Mohammad Imran Siddiqi. "CoMFA and CoMSIA 3D-QSAR analysis of DMDP derivatives as." Bioinformation 2, no. 9 (June 18, 2008): 384–91. http://dx.doi.org/10.6026/97320630002384.

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Srivastava, Vivek, Ashutosh Kumar, Bhartendu Nath x. Bhartendu Nath Mishra, and Mohammad Imran Siddiqi. "Molecular docking studies on DMDP derivatives as human DHFR inhibitors." Bioinformation 3, no. 4 (December 6, 2008): 180–88. http://dx.doi.org/10.6026/97320630003180.

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Bouillon, Marc E., and Stephen G. Pyne. "Diastereoselective concise syntheses of the polyhydroxylated alkaloids DMDP and DAB." Tetrahedron Letters 55, no. 2 (January 2014): 475–78. http://dx.doi.org/10.1016/j.tetlet.2013.11.068.

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Scher, Howard I., Alan Yagoda, Tauseef Ahmed, Daniel Budman, Peter Sordillo, and Robin C. Watson. "Phase-II trial of 4-demethoxydaunorubicin (DMDR) for advanced hypernephroma." Cancer Chemotherapy and Pharmacology 14, no. 1 (1985): 79–80. http://dx.doi.org/10.1007/bf00552731.

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Goher, Mohamed A. S., Franz A. Mautner, Afaf K. Hafez, and Adel A. Youssef. "Synthesis and characterization of copper(I) complexes of dimethyldipicolinate (dmdp) and X-ray structure of the mononuclear six-coordinate complex [Cu(dmdp)2]ClO4." Polyhedron 22, no. 4 (February 2003): 515–20. http://dx.doi.org/10.1016/s0277-5387(02)01416-x.

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Merino, Pedro, Ignacio Delso, Tomás Tejero, Francesca Cardona, Marco Marradi, Enrico Faggi, Camilla Parmeggiani, and Andrea Goti. "Nucleophilic Additions to Cyclic Nitrones en Route to Iminocyclitols – Total Syntheses of DMDP, 6-deoxy-DMDP, DAB-1, CYB-3, Nectrisine, and Radicamine B." European Journal of Organic Chemistry 2008, no. 17 (June 2008): 2929–47. http://dx.doi.org/10.1002/ejoc.200800098.

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GLOTOVA, I. A., N. A. GALOCHKINA, V. F. SELEMENEV, O. V. PEREGONCHAYA, and S. A. SOKOLOVA. "IR-SPECTROSCOPIC STUDY OF IMMOBILIZATION OF SELENIUM COMPOUNDS ON BIOMODIFIED COLLAGEN." Periódico Tchê Química 16, no. 33 (March 20, 2019): 159–68. http://dx.doi.org/10.52571/ptq.v16.n33.2019.174_periodico33_pgs_159_168.pdf.

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The aim of the work was to research the spectral characteristics of collagen substances bioengineered by using complex collagenolytic proteases preparation obtained before and after the immobilization of selenium compounds in acidic and alkaline media and to comparate the degree of interaction of selenium preparations with collagen matrix upon immobilization and its influence on the conformation of protein molecules. The results of the immobilization of selenium preparations on biomodified collagen by the IR spectroscopy method are presented, analyzed, and discussed. Biomodified collagen was obtained from beef trimming waste (veins and tendons) by sequential peroxide-alkaline and enzymatic hydrolysis with the food collagenase preparation. The following sources of selenium were used as compounds with bioprotective properties for subsequent immobilization on biomodified collagen proteins: 4,4-di[3(5-methyldiprazolil)]selenide (DMDPS) with the content of 0,657g DMDMS in 100 cm3 and sodium selenite. Spectrograms are carried out for products of biomodification of collagen before sorption of compounds of selenium, (at the rate of 1.2 g-6 of selenium on 1 g of collagen) in acid (рН =5) and alkaline (рН =10) environments at a research of influence of compounds of selenium on IR spectrums of products of biomodification of collagen. It was established, that the immobilization takes place by a chemical reaction of selenium preparations with functional groups of the side chains of protein molecules, and its degree varies in the range Na2SeO3 (pH=5) > 4,4-di[3(5-methyldiprazolil)]selenide (DMDPS) > Na2SeO3 (pH=10). It is shown that under the interaction of selenium products with collagen, there is no change in the conformations of its molecules occurred.

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FLORES, Francisco J., and Juan F. MARTÍN. "Iron-regulatory proteins DmdR1 and DmdR2 of Streptomyces coelicolor form two different DNA-protein complexes with iron boxes." Biochemical Journal 380, no. 2 (June 1, 2004): 497–503. http://dx.doi.org/10.1042/bj20031945.

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In high G+C Gram-positive bacteria, the control of expression of genes involved in iron metabolism is exerted by a DmdR [divalent (bivalent) metal-dependent regulatory protein] in the presence of Fe2+ or other bivalent ions. The dmdR1 and dmdR2 genes of Streptomyces coelicolor were overexpressed in Escherichia coli and the DmdR1 and DmdR2 proteins were purified to homogeneity. Electrophoretic mobility-shift assays showed that both DmdR1 and DmdR2 bind to the 19-nt tox and desA iron boxes forming two different complexes in each case. Increasing the concentrations of DmdR1 or DmdR2 protein shifted these complexes from their low-molecular-mass form to the high-molecular-mass complexes. Formation of the DNA–protein complexes was prevented by the bivalent metal chelating agent 2,2´-dipyridyl and by antibodies specific against the DmdR proteins. Cross-linking with glutaraldehyde of pure DmdR1 or DmdR2 proteins showed that DmdR1 forms dimers, whereas DmdR2 is capable of forming dimers and probably tetramers. Ten different iron boxes were found in a search for iron boxes in the genome of S. coelicolor. Most of them correspond to putative genes involved in siderophore biosynthesis. Since the nucleotide sequence of these ten boxes is identical (or slightly different) with the synthetic DNA fragment containing the desA box used in the present study, it is proposed that DmdR1 and DmdR2 bind to the iron boxes upstream of at least ten different genes in S. coelicolor.

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Yan, Xin, Yuna Shimadate, Atsushi Kato, Yi-Xian Li, Yue-Mei Jia, George W. J. Fleet, and Chu-Yi Yu. "Synthesis of Pyrrolidine Monocyclic Analogues of Pochonicine and Its Stereoisomers: Pursuit of Simplified Structures and Potent β-N-Acetylhexosaminidase Inhibition." Molecules 25, no. 7 (March 25, 2020): 1498. http://dx.doi.org/10.3390/molecules25071498.

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Ten pairs of pyrrolidine analogues of pochonicine and its stereoisomers have been synthesized from four enantiomeric pairs of polyhydroxylated cyclic nitrones. Among the ten N-acetylamino pyrrolidine analogues, only compounds with 2,5-dideoxy-2,5-imino-d-mannitol (DMDP) and pochonicine (1) configurations showed potent inhibition of β-N-acetylhexosaminidases (β-HexNAcases); while 1-amino analogues lost almost all their inhibitions towards the tested enzymes. The assay results reveal the importance of the N-acetylamino group and the possible right configurations of pyrrolidine ring required for this type of inhibitors.

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Xue, Jie, Xiyu Liu, Wenxing Sun, and Shuo Yan. "Discrete Morse Theory Based Dynamic P Systems." Journal of Advanced Computational Intelligence and Intelligent Informatics 22, no. 1 (January 20, 2018): 104–12. http://dx.doi.org/10.20965/jaciii.2018.p0104.

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This paper proposes a class of dynamic P systems with constraint of discrete Morse function (DMDP systems). Membrane structure is extended on complex. Rules control activities of membranes. New classes of rules and mechanism to change types of rules by discrete gradient vector field are provided as well.DMDP system extends P systems both in structures and rules. Solving air quality evaluation problem in linear time verifies the effectiveness ofDMDP systems. Since air quality evaluation problem has significance in many areas. The new P systems provide an alternative for traditional membrane computing.

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Tropel, David, and Jan Roelof van der Meer. "Identification and Physical Characterization of the HbpR Binding Sites of the hbpC and hbpD Promoters." Journal of Bacteriology 184, no. 11 (June 1, 2002): 2914–24. http://dx.doi.org/10.1128/jb.184.11.2914-2924.2002.

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ABSTRACT Pseudomonas azelaica HBP1 can use 2-hydroxybiphenyl (2-HBP) and 2,2′-dihydroxybiphenyl as sole carbon and energy sources by means of the hbp regulon. This regulon is composed of three genes, hbpCA and hbpD, coding for enzymes of a meta-cleavage pathway and the hbpR gene, which codes for a XylR/DmpR-type transcription regulator. It was previously shown that HbpR activates transcription from two σ54-dependent promoters, P hbpC and P hbpD , in the presence of 2-HBP. In this study, by using gel mobility shift assays with a purified fusion protein containing calmodulin binding protein (CBP) and HbpR, we detected two binding regions for HbpR in P hbpC and one binding region in P hbpD . DNase I footprints of the proximal binding region of P hbpC and of the binding region in P hbpD showed that CBP-HbpR protected a region composed of two inverted repeat sequences which were homologous to the binding sites identified for XylR. Unlike the situation in the XylR/P u system, we observed simultaneous binding of CBP-HbpR on the two upstream activating sequences (UASs). Fragments with only one UAS did not show an interaction with HbpR, indicating that both pairs of UASs are needed for HbpR binding. The addition of both ATP and 2-HBP increased the DNA binding affinity of HbpR. These results showed for the first time that, for regulators of the XylR/DmpR type, the effector positively affects the recruitment of the regulatory protein on the enhancer DNA.

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Hao, X. F., L. Alphey, L. R. Bandara, E. W. Lam, D. Glover, and N. B. La Thangue. "Functional conservation of the cell cycle-regulating transcription factor DRTF1/E2F and its pathway of control in Drosophila melanogaster." Journal of Cell Science 108, no. 9 (September 1, 1995): 2945–54. http://dx.doi.org/10.1242/jcs.108.9.2945.

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The cellular transcription factor DRTF1/E2F is implicated in the control of early cell cycle progression due to its interaction with important regulators of cellular proliferation, such as pocket proteins (for example, the retinoblastoma tumour suppressor gene product), cyclins and cyclin-dependent kinase subunits. In mammalian cells DRTF1/E2F is a heterodimeric DNA binding activity which arises when a DP protein interacts with an E2F protein. Here, we report an analysis of DRTF1/E2F in Drosophila cells, and show that many features of the pathway which regulate its transcriptional activity are conserved in mammalian cells, such as the interaction with pocket proteins, binding to cyclin A and cdk2, and its modulation by viral oncoproteins. We show that a Drosophila DP protein which can interact co-operatively with E2F proteins is a physiological DNA binding component of Drosophila DRTF1/E2F. An analysis of the expression patterns of a Drosophila DP and E2F protein indicated that DmDP is developmentally regulated and in later embryonic stages preferentially expressed in proliferating cells. In contrast, the expression of DmE2F-1 in late stage embryos occurs in a restricted group of neural cells, whereas in early embryos it is widely expressed, but in a segmentally restricted fashion. Some aspects of the mechanisms which integrate early cell cycle progression with the transcription apparatus are thus conserved between Drosophila and mammalian cells. The distinct expression patterns of DmDP and DmE2F-1 suggest that the formation of DP/E2F heterodimers, and hence DRTF1/E2F, is subject to complex regulatory cues.

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Ng, Lee Ching, Eric O'Neill, and Victoria Shingler. "Genetic Evidence for Interdomain Regulation of the Phenol-responsive54-dependent Activator DmpR." Journal of Biological Chemistry 271, no. 29 (July 19, 1996): 17281–86. http://dx.doi.org/10.1074/jbc.271.29.17281.

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41

Sze, Chun Chau, Andrew D. Laurie, and Victoria Shingler. "In Vivo and In Vitro Effects of Integration Host Factor at the DmpR-Regulated ς54-Dependent Po Promoter." Journal of Bacteriology 183, no. 9 (May 1, 2001): 2842–51. http://dx.doi.org/10.1128/jb.183.9.2842-2851.2001.

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ABSTRACT Transcription from the Pseudomonas CF600-derived ς54-dependent promoter Po is controlled by the aromatic-responsive activator DmpR. Here we examine the mechanism(s) by which integration host factor (IHF) stimulates DmpR-activated transcriptional output of the Po promoter both in vivo and in vitro. In vivo, the Po promoter exhibits characteristics that typify many ς54-dependent promoters, namely, a phasing-dependent tolerance with respect to the distance from the regulator binding sites to the distally located RNA polymerase binding site, and a strong dependence on IHF for optimal promoter output. IHF is shown to affect transcription via structural repercussions mediated through binding to a single DNA signature located between the regulator and RNA polymerase binding sites. In vitro, using DNA templates that lack the regulator binding sites and thus bypass a role of IHF in facilitating physical interaction between the regulator and the transcriptional apparatus, IHF still mediates a DNA binding-dependent stimulation of Po transcription. This stimulatory effect is shown to be independent of previously described mechanisms for the effects of IHF at ς54 promoters such as aiding binding of the regulator or recruitment of ς54-RNA polymerase via UP element-like DNA. The effect of IHF could be traced to promotion and/or stabilization of open complexes within the nucleoprotein complex that may involve an A+T-rich region of the IHF binding site and promoter-upstream DNA. Mechanistic implications are discussed in the context of a model in which IHF binding results in transduction of DNA instability from an A+T-rich region to the melt region of the promoter.

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Huang, Mu-Hua, Yi-Xian Li, Yue-Mei Jia, and Chu-Yi Yu. "General Intermediates for the Synthesis of 6-C-Alkylated DMDP-Related Natural Products." Molecules 18, no. 6 (June 7, 2013): 6723–33. http://dx.doi.org/10.3390/molecules18066723.

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Tsou, En-Lun, Yao-Ting Yeh, Pi-Hui Liang, and Wei-Chieh Cheng. "A convenient approach toward the synthesis of enantiopure isomers of DMDP and ADMDP." Tetrahedron 65, no. 1 (January 2009): 93–100. http://dx.doi.org/10.1016/j.tet.2008.10.096.

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García-Moreno, M. Isabel, Matilde Aguilar, Carmen Ortiz Mellet, and José M. García Fernández. "Intramolecular Benzyl Protection Delivery: A Practical Synthesis of DMDP and DGDP fromd-Fructose." Organic Letters 8, no. 2 (January 2006): 297–99. http://dx.doi.org/10.1021/ol052668u.

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Fellows, L. E., M. S. Phillips, T. J. W. Alphey, W. J. McGavin, I. E. Geoghegan, M. S. J. Simmonds, W. M. Robertson, A. A. Watson, A. N. E. Birch, and E. A. Porter. "Dmdp - a Plant-Derived Sugar Analogue With Systemic Activity Against Plant Parasitic Nematodes." Nematologica 39, no. 1-4 (1993): 521–35. http://dx.doi.org/10.1163/187529293x00466.

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Lee, Su-Jin, In-Young Baek, Yan An, Woo-Chan Ahn, Kwang-Hyun Park, and Eui-Jeon Woo. "Purification, crystallization and X-ray crystallographic analysis of ATPase domain in transcription regulator DmpR." Korean Society for Structural Biology 7, no. 2 (June 30, 2019): 52–55. http://dx.doi.org/10.34184/kssb.2019.7.2.52.

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Li, Yi-Xian, Mu-Hua Huang, Yukiko Yamashita, Atsushi Kato, Yue-Mei Jia, Wu-Bao Wang, George W. J. Fleet, Robert J. Nash, and Chu-Yi Yu. "l-DMDP, l-homoDMDP and their C-3 fluorinated derivatives: synthesis and glycosidase-inhibition." Organic & Biomolecular Chemistry 9, no. 9 (2011): 3405. http://dx.doi.org/10.1039/c0ob01063d.

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Shingler, V., and H. Pavel. "Direct regulation of the ATPase activity of the transcriptional activator DmpR by aromatic compounds." Molecular Microbiology 17, no. 3 (August 1995): 505–13. http://dx.doi.org/10.1111/j.1365-2958.1995.mmi_17030505.x.

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Seibt, Henrik, Uwe H. Sauer, and Victoria Shingler. "The Y233 gatekeeper of DmpR modulates effector‐responsive transcriptional control of σ54‐RNA polymerase." Environmental Microbiology 21, no. 4 (March 7, 2019): 1321–30. http://dx.doi.org/10.1111/1462-2920.14567.

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O'Neill, Eric, Lee Ching Ng, Chun Chau Sze, and Victoria Shingler. "Aromatic ligand binding and intramolecular signalling of the phenol-responsive σ54-dependent regulator DmpR." Molecular Microbiology 28, no. 1 (May 1, 2002): 131–41. http://dx.doi.org/10.1046/j.1365-2958.1998.00780.x.

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