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Dissertations / Theses on the topic 'Diseases of Tea'

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1

Chen, Juhua, and 陳菊華. "Green tea polyphenols modulate carbon tetrachloride-induced liver injury in mice." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31242935.

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2

Bursill, Christina. "Green tea and its catechins modulate cholesterol metabolism in cultured human liver (HepG2) cells and the hypercholesterolaemic rabbit." Title page, contents and introduction only, 2000. http://web4.library.adelaide.edu.au/theses/09PH/09pdb9725.pdf.

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Includes bibliographical references (21 leaves). Previous studies have found that green tea and its antitoxidant constituents, the catechins, are hypocholesterolaemic in both epidemiological and animal intervetion studies. The main objectives of the present study were to investigate the mechanism by which green tea and its most abundant catechin constituent epigallocatechin gallate increase the low-density lipoprotein (LDL) receptor of HepG2 cells. In addition, it was hoped to determine if a crude catechin extract from green tea could lower plasma cholesterol levels in the hypercholesterolaemi
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Kobese, Nokubonga. "Synthesis of silver doped titanium dioxide nanocomposites using tea extract from Aspalathus linearis and evaluation of their antibacterial effects." University of the Western Cape, 2018. http://hdl.handle.net/11394/6779.

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>Magister Scientiae - MSc<br>Despite the wide success of antimicrobial agents against waterborne pathogens, waterborne disease continues to pose a threat to both mankind and animals. A major concern is that certain bacteria have developed resistance to antimicrobial agents, as a result of their overuse. Silver (Ag) nanoparticles are widely used for antibacterial purposes such as medical dressings. However, they are highly toxic to human cells. Hence, there is a great interest in developing next generation antibacterial nanoparticles that are as effective as Ag nanoparticles for antibacterial f
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4

Spies, Christoffel F. J. (Christoffel Frederik Jakobus). "The inoculum ecology of Botrytis cinerea in Rooibos nurseries." Thesis, Stellenbosch : Stellenbosch University, 2005. http://hdl.handle.net/10019.1/20943.

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Thesis (MScAgric)--University of Stellenbosch, 2005.<br>ENGLISH ABSTRACT: Grey mould, caused by Botrytis cinerea, is the most important foliar disease of rooibos seedlings. Although the disease is primarily controlled with applications of fungicides, the improvement of cultural methods of disease management should lessen this dependence on chemical control. Such improvements would, however, not be possible without knowledge of the inoculum sources and dispersal of the pathogen. The aim of this study was to investigate the inoculum ecology of B. cinerea in rooibos nurseries in order to ide
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5

Kirana, Chandra. "Bio-active compounds isolated from mistletoe (Scurulla oortiana (Korth.) Danser) parasitizing tea plant (Camellia sinensis L.)." Title page, contents and summary only, 1996. http://web4.library.adelaide.edu.au/theses/09A/09ak58.pdf.

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Bibliography: leaves 87-96. This thesis investigates non-proteinaceous low molecular weight flavonoid and alkaloid compounds in Scurulla oortiana (Korth.) Danser grown on Camellia sinens. Three flavonols are identified in S. oortiana (Korth.) Danser growing on different hosts. The identification and characterisation of these flavonoids are carried out using various chromatographic and spectrometric procedures. Two purine alkaloids are isolated from and identified in S. oortiana (Korth.) Danser parasitizing tea plant, C. Sinensis. The antifungal activity of the phenolic compounds isolated from
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6

Kunsevi-Kilola, Carine. "The effect of Rooibos on trace elements absorption and biochemical parameters : a murine model." Thesis, Cape Peninsula University of Technology, 2014. http://hdl.handle.net/20.500.11838/2248.

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Thesis (MTech (Biomedical Technology))--Cape Peninsula University of Technology, 2014.<br>Over the past few decades, it has been shown that various critical diseases including heart disease, cancer, and diabetes associated with free radical generation and low endogenous antioxidant capacity, lead to oxidative stress and cell injury. In recent years, numerous studies have also reported that antioxidants, present in various beverages, vegetables and some foods have attracted a significant research interest due to their potential benefits to human health. However, epidemiological evidence sh
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7

朱雯 and Wen Zhu. "The potential roles of nitric oxide in carbon tetrachloride induced liver injury of mice and the protective effects of green teapolyphenols." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31241426.

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8

Thamahane-Katengua, Emma Tutu Masechela. "Effect of rooibos and red palm oil supplementation, alone or in combination, on cardiac function after exposure to hypertension and inflammation in an ischaemial/reperfusion injury model." Thesis, Cape Peninsula University of Technology, 2013. http://hdl.handle.net/20.500.11838/1520.

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Thesis submitted in fulfilment of the requirement for the degree Doctor of Technologiae (Biomedical Technology) in the Faculty of Health and Wellness Sciences at the Cape Peninsula University of Technology Supervisor: Prof J van Rooyen Co-supervisor: Prof JL Marnewick Bellville October 2013<br>Cardiovascular disease (CVD) is without a doubt one of the most challenging health issues of our time and accounts for the highest number of deaths in both developed and developing countries. Despite the huge strides that have been achieved in the diagnosis and therapeutic intervention of CVD, t
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9

Deikun, Larissa Loryn. "The Health and Growth of Veal Calves Provided a Fatty Acid Supplement and a Dry Teat." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1563380406594548.

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10

Ehrnhöfer, Dagmar Elisabeth. "Green tea catechins change the aggregation behavior of proteins associated with neurodegenerative disease." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2007. http://dx.doi.org/10.18452/15624.

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Eine Gemeinsamkeit verschiedener neurodegenerativer Erkrankungen ist die abnormale Ansammlung von Proteinen im Gehirn, wie z. B. von alpha-Synuclein (Syn)-Aggregaten bei der Parkinson''schen Krankheit (PD) oder von Huntingtin (Htt)-Aggregaten bei Chorea Huntington (HD). Am Anfang dieser Studie wurde eine Bibliothek von ca. 5000 natürlichen Substanzen nach Inhibitoren der Htt-Aggregation durchsucht. Eine der wirksamen Substanzen war (-)-Epigallocatechingallat (EGCG), eine Verbindung, die in grünem und schwarzem Tee vorkommt. Die antioxidativen Eigenschaften von EGCG wurden bereits mit einer
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11

Brantman, Karen Renee. "Tear Film VEGF in Dogs with Vascularizing Corneal Disease." Thesis, Virginia Tech, 2013. http://hdl.handle.net/10919/23166.

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This body of work encompasses two studies: the collection of canine tears via a novel polyester<br />rod and the comparison of VEGF-A concentrations in tears from dogs with normal and<br />vascularized corneas. The first study used polyester rods for tear collection in dogs. Fluid volume and VEGF recovery characteristics, as well as potential binding of VEGF to the rod, were determined. Tears were harvested from normal dogs using rods and glass capillary tubes. Tears were assayed for tear film VEGF using a commercial canine VEGF sandwich ELISA kit. Dilutions of VEGF standard were wicked into t
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12

Roy, Elise. "Cell disorders in lysosomal storage diseases." Phd thesis, Université René Descartes - Paris V, 2012. http://tel.archives-ouvertes.fr/tel-00683248.

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Mucopolysaccharidosis type IIIB (MPSIIIB) is a lysosomal storage disease (LSD) characterized by accumulation of heparan sulfate oligosaccharides (HSO), which results in progressive mental retardation, neurodegeneration and premature death in children. The underlying mechanisms are poorly understood. Coming to a better understanding of the pathophysiology of MPSIIIB has become a necessity to assess the efficacy of gene therapy treatment regarding loss of neuronal plasticity, and to define the best conditions for treatment. To address the link between HSO accumulation and downstream pathological
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Macharia, Muiruri. "Modulation of oxidative stress biomarkers by rooibos in adults at risk of developing coronary heart disease /." [S.l. : s.n.], 2008. http://dk.cput.ac.za/cgi/viewcontent.cgi?article=1024&context=td_cput.

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14

Cioe, Patricia A. "Cardiovascular Risk Factor Knowledge, Risk Perception, and Actual Risk in HIV-Infected Patients: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsn_diss/26.

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Background: Cardiovascular disease (CVD) has emerged as a major cause of morbidity and mortality in HIV-infected adults. Research in noninfected populations suggests that knowledge of CVD risk factors significantly influences perception of risk. Understanding the level of risk factor knowledge and risk perception can inform the development of innovative interventions to reduce risk. The purpose of this study was to describe cardiovascular risk factor knowledge and risk perception in a cohort of HIV-infected adults. Specific aims included (a) describing the estimated risk of CVD, the perceived
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15

Rezai-Zadeh, Kavon. "Flavonoids as Modulators of Amyloid Precursor Protein Metabolism and Alzheimer Disease Pathology." [Tampa, Fla] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002683.

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16

Wickwar, Sadie. "The psychosocial and clinical outcomes of surgery for Thyroid Eye Disease (TED)." Thesis, City University London, 2014. http://openaccess.city.ac.uk/14502/.

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This study aimed to investigate whether quality of life in patients with thyroid eye disease (TED) improves as a result of having orbital decompression surgery and whether any demographic, clinical or psychosocial factors can predict which patients might benefit from this surgery. One hundred and twenty three adults with TED were recruited from Moorfields Eye Hospital (MEH), London. Clinical measurements were taken by the clinical team at MEH and participants completed a range of psychosocial questionnaires prior to surgery and again 6 weeks and 6 months after surgery. The Appearance Research
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17

Gartner, Coral Elizabeth. "Environmental risk factors for Parkinson's disease." Queensland University of Technology, 2006. http://eprints.qut.edu.au/16393/.

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Parkinson's disease (PD) is a progressive, degenerative, neurological disease. The progressive disability associated with PD results in substantial burdens for those with the condition, their families and society in terms of increased health resource use, earnings loss of affected individuals and family caregivers, poorer quality of life, caregiver burden, disrupted family relationships, decreased social and leisure activities, and deteriorating emotional well-being. Currently, no cure is available and the efficacy of available treatments, such as medication and surgical interventions, decreas
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Gartner, Coral Elizabeth. "Environmental risk factors for Parkinson's disease." Thesis, Queensland University of Technology, 2006. https://eprints.qut.edu.au/16393/1/Coral_Gartner_Thesis.pdf.

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Parkinson's disease (PD) is a progressive, degenerative, neurological disease. The progressive disability associated with PD results in substantial burdens for those with the condition, their families and society in terms of increased health resource use, earnings loss of affected individuals and family caregivers, poorer quality of life, caregiver burden, disrupted family relationships, decreased social and leisure activities, and deteriorating emotional well-being. Currently, no cure is available and the efficacy of available treatments, such as medication and surgical interventions, decreas
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19

Harris, Bertha J. "Veteran Administration Disease Model to an Interdisciplinary Healthcare Model." ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/6574.

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There is a growing need for healthcare teams within the Veterans Administration (VA) healthcare system to effectively collaborate and communicate to improve patient outcomes. The need to improve patient care in the Patient Aligned Care Team (PACT) has been well established. The scholarly literature does not provide evidence whether using the primary care PACT model on communication and teamwork by an interdisciplinary medical team ameliorates these communication breakdowns. Bronstein's design for interdisciplinary collaboration provided the overarching framework for this study. The purpose of
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20

Giancardo, Luca. "Automated fundus images analysis techniques to screen retinal diseases in diabetic patients." Phd thesis, Université de Bourgogne, 2011. http://tel.archives-ouvertes.fr/tel-00692354.

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In this Ph.D. thesis, we study new methods to analyse digital fundus images of diabetic patients. In particular, we concentrate on the development of the algorithmic components of an automatic screening system for diabetic retinopathy. The techniques developed can be categorized in: quality assessment and improvement, lesion segmentation and diagnosis. For the first category, we present a fast algorithm to numerically estimate the quality of a single image by employing vasculature and colour-based features; additionally, we show how it is possible to increase the image quality and remove refle
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21

Mahmood, Dler Faieeq Darweesh. "Thioredoxin-1 (Trx1) : a new target in the treatment of cardiovascular diseases." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2014. http://tel.archives-ouvertes.fr/tel-01069096.

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The cardiovascular diseases (CVDs), resulting from complications of atherosclerosis, remain the leading cause of morbidity and death worldwide. Atherosclerosis as a chronic inflammatory disease, involves both innate and adaptive arms of immunity in which macrophages play the orchestral role in modulating lesion initiation, progression, and potentially devastating thrombotic complications. Available evidences support the notion of a central role of oxidative stress, due mainly to the imbalance between antioxidants and reactive oxygen species (ROS) in CVDs. Furthermore, the pathology is frequent
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22

Kaffashian, Sara. "Cognitive Aging : Role of Cardiovascular Disease Risk Factors." Phd thesis, Université Paris Sud - Paris XI, 2013. http://tel.archives-ouvertes.fr/tel-00940586.

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Several cardiovascular disease risk factors including, dyslipidemia, high blood pressure, and diabetes have been proposed as important modifiable risk factors for cognitive decline and dementia. These risk factors often co-occur and their aggregation is associated with increased risk of cardiovascular disease and dementia. However, studies of composite measures of cardiovascular disease risk in relation to cognitive outcomes in non-elderly populations are scarce. The aim of this thesis was to examine composite measures of risk in relation to cognition and longitudinal cognitive change amongmid
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23

Brambilla, Davide. "Polymeric nanoparticles as original theranostic approach for alzheimer‟s disease." Phd thesis, Université Paris Sud - Paris XI, 2012. http://tel.archives-ouvertes.fr/tel-00692581.

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The proof of concept of an original nanotechnology-based theranostic approach for Alzheimer‟s disease has been explored. Novel fluorescently tagged nanoparticles have been designed and employed for internalization and transcytosis studies across a recently developed human in vitro blood-brain barrier model. A small library of polymeric nanoparticles have been designed and their ability to capture the Amyloid β1-42 peptide, considered one of the causes of the Alzheimer‟s disease, has been investigated and quantified using an on purpose designed method.
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24

Laveneziana, Pierantonio. "Dynamic lung hyperinflation as the common pathway for exercise-induced dyspnoea in cardio-respiratory diseases." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2012. http://tel.archives-ouvertes.fr/tel-00831616.

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Les patients atteints de BPCO de stade I, d'ICC et d'HTAP peuvent présenter une diminution des débits aériens à bas volume pulmonaire. Il s'agit d'un déterminant majeur de la distension thoracique dynamique, particulièrement délétère, et facteur important de la dyspnée d'exercice. Nos travaux montrent sans ambiguïté une forte association entre la distension thoracique dynamique (limitant l'augmentation du volume courant) et la dyspnée à l'effort chez ces patients. Le corollaire de ces constatations est que des interventions thérapeutiques qui réduisent la distension thoracique devraient diminu
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25

Pan, Xiaoxi. "Towards FDG-PET image characterization and classification : application to Alzheimer's disease computer-aided diagnosis." Thesis, Ecole centrale de Marseille, 2019. http://www.theses.fr/2019ECDM0008.

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La maladie d’Alzheimer (MA) est la maladie neurodégénérative--incurable et irréversible pour le moment--la plus répandue chez les personnes âgées. On s’attend à ce qu’elle soit diagnostiquée à son stade précoce, Mild Cognitive Impairment (MCI), pour pouvoir intervenir et retarder son apparition. La tomographie par émission de positons au fluorodésoxyglucose (TEP-FDG) est considérée comme une modalité efficace pour diagnostiquer la MA et la phase précoce correspondante, car elle peut capturer les changements métaboliques dans le cerveau, indiquant ainsi des régions anormales. Cette thèse est co
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Boman, Åse. "Fathers involved in children with type 1 diabetes : finding the balance between disease control and health promotion." Doctoral thesis, Högskolan Väst, Avd för vårdvetenskap på avancerad nivå, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-5808.

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Background: Type I diabetes is a chronic disease that places great demands on the child and family. Parental involvement has been found to be essential for disease outcome. However, fathers’ involvement has been less studied, even though high paternal involvement has been correlated with less disease impact on the family and higher quality of life among adolescents. Aim: The overall aim of the study was to explore and analyze constructions of fathers’ involvement in their child’s everyday life with type 1 diabetes from an ecological and health promotion perspective. Four specific aims were app
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Zheng, Sang Guo. "Therapeutic effects of TGT-β induced regulatory T cells on the established autoimmune and inflammatory diseases". Phd thesis, Université d'Orléans, 2011. http://tel.archives-ouvertes.fr/tel-00698579.

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Recent studies revealed that nTregs has less therapeutic effects on established autoimmune diseases. Current study asks if iTregs induced ex-vivo with TGF- can treat the established autoimmune diseases. In allergic asthma we observed that adoptive transfer of iTreg significantly suppressed airway and peri-vascular inflammation, reduced airway résistance, eosinophil recruitment, mucus hyper-production, airway remodeling and IgE levels. This therapeutic effect was associated with increase of Tregs (CD4+Foxp3+) in the draining LNs, and with reduction of Th1, Th2, and Th17 responses. In collagen-i
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Shen, Kai-kai. "Automatic segmentation and shape analysis of human hippocampus in Alzheimer's disease." Phd thesis, Université de Bourgogne, 2011. http://tel.archives-ouvertes.fr/tel-00703099.

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The aim of this thesis is to investigate the shape change in hippocampus due to the atrophy in Alzheimer's disease (AD). To this end, specific algorithms and methodologies were developed to segment the hippocampus from structural magnetic resonance (MR) images and model variations in its shape. We use a multi-atlas based segmentation propagation approach for the segmentation of hippocampus which has been shown to obtain accurate parcellation of brain structures. We developed a supervised method to build a population specific atlas database, by propagating the parcellations from a smaller gener
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Pemberton, Samantha. "Molecular chaperones in the assembly of α-Synuclein and Parkinson's Disease". Phd thesis, Université Paris Sud - Paris XI, 2011. http://tel.archives-ouvertes.fr/tel-00762970.

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The formation and deposition of α-Synuclein fibrils in the human brain is at the origin of Parkinson's disease. The objective of my thesis was to document the role of two molecular chaperones on the assembly of α-Syn into fibrils: Hsc70, a constitutively expressed human heat shock protein, and Ssa1p, its yeast equivalent. The aim was to expand the catalogue of known effects of molecular chaperones on the PD implicated protein, which could have therapeutic significance. We showed that Hsc70 inhibits the assembly of α-Syn into fibrils, by binding with high affinity to the soluble form of α-Syn.
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Dudley, Alicia A. "An Investigation of the Multifaceted Platelet Dysfunction in Dogs with Naturally-Occurring Chronic Kidney Disease." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1405012077.

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31

Tollefson, Stacy Joy. "Compost Water Extracts And Suppression Of Root Rot (F. Solani F. Sp. Pisi) In Pea: Factors Of Suppression And A Potential New Mechanism." Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/338972.

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One of the motivating reasons for the development of hydroponics was avoidance of root pathogens. Hydroponics involves growing crops in relatively sterile media, isolated from the underlying soil which may have disease pressure. However, even when hydroponics is coupled with controlled environments such as high tunnels and climate-controlled greenhouses, soil-borne pathogens can enter the growing area and proliferate due to optimal environmental conditions for pathogen growth. Control of root pathogens is difficult and usually achieved through synthetic fungicides since few biocontrol options
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Laval, Julie. "Metabolic adaptation of inflammatory neutrophils in human diseases revealed by retroviral envelope-derived ligands : focus on cystic fibrosis." Phd thesis, Université Montpellier II - Sciences et Techniques du Languedoc, 2013. http://tel.archives-ouvertes.fr/tel-01021456.

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The present study focuses on adaptive metabolic steps adopted by neutrophils during inflammation, particularly during their recruitment into the cystic fibrosis (CF) airways. In CF, we previously described that airway neutrophils are alive and undergo reprogramming, featuring notably the activation of the anabolic mTOR pathway. The present work is based on specific properties of soluble ligands derived from the receptor-binding domains (RBD) of retroviral glycoprotein envelopes, which can be used for the detection of metabolite transporters at the cell surface. First, we validated the use of t
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Widy, Sarah, Andrea Bisceglia, Emily Bradley, et al. "Young Adults with Cleft Lip and Palate: Are They Receiving Team Services?" Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/2151.

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It is widely acknowledged that a team approach is preferred practice and contributes to optimizing the surgical, dental, speech and psychosocial outcomes for individuals with CLP. Young adulthood often marks the transition from child-centered interdisciplinary care to adult-centered care. There is a paucity in literature relating to the transition of care for young adults with CLP. The purpose of this survey research is therefore to explore the CLP team practices regarding young adults with CLP.
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Mallett, Susan Veronica. "The clinical utility of viscoelastic tests of coagulation (TEG® & ROTEM®) in liver disease and liver surgery." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1476864/.

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This thesis focuses on what is currently known about the haemostatic changes that occur in liver disease, and also those that follow major liver resection. Although there has been considerable work on the changes in coagulation in both acute and chronic liver disease in recent years, there has been far less attention to hepatic resection. This is also an important area for study as an elevation of PT/INR is common in the first few days after resection, yet these patients are known to have a high incidence of thromboembolic complications in the early post operative period, and this risk appears
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Grano, Maldonado Mayra Ixchel. "The biological and behavioural basis of host selection in the transmission of Gyrodactylus (Monogenea)." Thesis, University of Stirling, 2010. http://hdl.handle.net/1893/3700.

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The ectoparasitic monogenean fluke, Gyrodactylus salaris, is a parasite known to be highly pathogenic to Atlantic salmon (Salmo salar). Although present in the environment of several neighbouring European countries, the UK is thought to be G. salaris-free, but, if national contingency plans to control this parasite are to be effective, it is vital that we understand the factors underlying its transmission from host to host. This study demonstrates that the majority of parasites transferring to new hosts are mature parasites that have reproduced at least once. Since, exploration and host transf
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Sharma, Meenu. "Interactions cellulaires et moléculaires entre basophiles et lymphocytes T CD4+." Phd thesis, Université de Technologie de Compiègne, 2014. http://tel.archives-ouvertes.fr/tel-01066885.

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Les basophiles sont les granulocytes les plus rares. Ils sont impliqués dans la polarisation des réponses immunitaires de type Th2, dans la différenciation des lymphocytes B et dans la protection contre les infections helminthiques. Les basophiles sont impliqués dans la modulation des réponses immunitaires, en particulier dans les maladies auto-immunes et inflammatoires. Des études récentes ont montré que les basophiles murins sont cellules présentatrices d'antigène (CPA) et induisent des réponses Th2 et IgE contre les allergènes et les infections helminthiques.Par conséquent, Nous avons explo
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Lorenzi, Marco. "Deformation-based morphometry of the brain for the development of surrogate markers in Alzheimer's disease." Phd thesis, Université de Nice Sophia-Antipolis, 2012. http://tel.archives-ouvertes.fr/tel-00844577.

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The aim of the present thesis is to provide an e ffective computational framework for the analysis and quantifi cation of the longitudinal structural changes in Alzheimer's disease (AD). The framework is based on the diffeomorphic non-rigid registration parameterized by stationary velocity fields (SVFs), and is hierachically developed to account for the diff erent levels of variability which characterize the longitudinal observations of T1 brain magnetic resonance images (MRIs). We developed an effi cient and robust method for the quantifi cation of the structural changes observed between pair
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38

Addo, Emilia K. "Chronic Care Model Staff Education and Adherence with End-Stage Renal Disease Patients." ScholarWorks, 2015. https://scholarworks.waldenu.edu/dissertations/1813.

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The management and treatment of chronic diseases, such as end-stage renal disease, is often unproductive because of patients' poor adherence to treatment. The chronic care model toolkit is an Agency for Healthcare Research and Quality supported framework, associated with improved outcomes in patients living with chronic disease. The purpose of this project was to develop and plan an educational program using the chronic care model toolkit for the interdisciplinary clinical staff of a renal hemodialysis center. The goal of this project was to adapt team building between patients and their clini
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BERTOLDI, GIOVANNI. "Assessment of oxidative stress and cardiovascular-renal remodelling in the X-linked rare Fabry disease. Evaluation of the antioxidant effect of green tea treatment on top of Enzyme Replacement Therapy." Doctoral thesis, Università degli studi di Padova, 2022. http://hdl.handle.net/11577/3456146.

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La malattia di Fabry è una rara disfunzione metabolica conseguente ad una mutazione nel gene galattosidasi alpha (GLA) localizzato nel cromosoma X che codifica per l’enzima α-galattosidasi A (α-galA) implicato nel metabolismo dei glicosfingolipidi, in modo particolare della globotriaosilceramide (Gb3) e derivati. Le differenti mutazioni comportano un’alterata espressione ed attività dell’enzima α-galA con il conseguente accumulo dei suoi substrati all’interno dei lisosomi e l’insorgenza di una malattia sistemica. L'attuale linea di trattamento è la terapia enzimatica sostitutiva (ERT) la quale
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Cope, Julie K. "Exploring the Effect of an Interdisciplinary Teamwork Intervention in Acute Rehabilitation." BYU ScholarsArchive, 2016. https://scholarsarchive.byu.edu/etd/6459.

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Purpose: The purpose of this study was to explore the efficacy of an interdisciplinary intervention on interdisciplinary teamwork and patient functional outcomes in an acute inpatient rehabilitation unit at a mid-sized regional hospital. Design: Pilot mixed-methods pre-post intervention study. Methods: Interdisciplinary teamwork and patient functional outcomes were measured before and after a teamwork intervention. Interdisciplinary teamwork was measured with the Healthcare Team Vitality Instrument (HTVI) and a qualitative staff questionnaire developed by a content expert. Patient functional
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41

Li, Cheng-Rui Michael. "The Role of Tec Kinases in CD4+ T Cell Activation: A Dissertation." eScholarship@UMMS, 2005. https://escholarship.umassmed.edu/gsbs_diss/3.

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The Tec family tyrosine kinases Itk, Tec and Rlk are expressed in T cells. Previous studies have established that these kinases are critical for TCR signaling, leading to the activation of PLCγ1. To further understand the functions of Tec kinases in T cell activation, we took three different approaches. First, we performed a thorough analysis of CD28-mediated signaling events and functional responses with purified naïve T cells from Itk-/- mice and a highly controlled stimulation system. Data from this set of studies definitively demonstrate that CD28 costimulation functions efficiently in naï
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Topham, Maren. "Parental Attitudes of Immunization in Children with Special Healthcare Needs: A Qualitative Study." BYU ScholarsArchive, 2017. https://scholarsarchive.byu.edu/etd/7271.

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Background and Purpose: Just over 15% of children under 18 years of age in the UnitedStates, or approximately 11.2 million children, are estimated to have special healthcare needs.Although children with special healthcare needs (CSHCN) make up a small percentage of thepediatric population, they account for over one third of pediatric medical care. Parental attitudesregarding immunization play a significant role in vaccination rates among children. The purposeof this research is to explore parental attitudes regarding immunization of CSHCN.Methods: This qualitative study focused on parental per
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Manoharan, Malini. "Genomic, structural and functional characterization of odorant binding proteins in olfaction of mosquitoes involved in infectious disease transmission." Phd thesis, Université de la Réunion, 2011. http://tel.archives-ouvertes.fr/tel-00979587.

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The role of odorant binding proteins in the olfaction of mosquitoes, the primary mechanism of human host recognition, has been an important focus of biological research in the field of infectious disease transmission by these insects. This thesis provides an in depth knowledge of these proteins in three mosquito species Anopheles gambiae, Aedes aegypti and Culex quinquefasciatus. A large scale analysis on these genomes has been carried out towards the identification of the odorant binding proteins in the mosquito genomes. Identification of many new OBP members, in particular in the Aedes aegyp
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Vellaiswamy, Manohari. "Characterization of mechanisms involved in rickettsia pathogenicity." Phd thesis, Université de la Méditerranée - Aix-Marseille II, 2011. http://tel.archives-ouvertes.fr/tel-00640585.

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Les rickettsies sont de petites bactéries à Gram-négatif associées à différentes espèces d'arthropodes. Leur nature intracellulaire stricte a longtemps été un obstacle à la compréhension des mécanismes moléculaires responsables de leur pathogénicité qui restent mal connus. L'adhésion bactérienne, qui est une étape clef de l'invasion des tissus de l'hôte, met en jeu les protéines rOmpA et rOmpB (rickettsial outer membrane proteins), identifiées depuis longtemps comme des antigènes de surface majeurs des rickettsies. L'objectif de cette thèse a été de caractériser une autre adhésine potentielle
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Weisenberger, Kimberly R. "Tear Lipid Layer Thickness and Symptoms in Patients with Dry Eye Disease following the use of Emollient versus Non-Emollient Artificial Tears." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu158694773242849.

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46

Loucoubar, Cheikh. "Statistical genetic analysis of infectious disease (malaria) phenotypes from a longitudinal study in a population with significant familial relationships." Phd thesis, Université René Descartes - Paris V, 2012. http://tel.archives-ouvertes.fr/tel-00685104.

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Long term longitudinal surveys have the advantage to enable several sampling of the studied phenomena and then, with the repeated measures obtained, find a confirmed tendency. However, these long term surveys generate large epidemiological datasets including more sources of noise than normal datasets (e.g. one single measure per observation unit) and potential correlation in the measured values. Here, we studied data from a long-term epidemiological and genetic survey of malaria disease in two family-based cohorts in Senegal, followed for 19 years (1990-2008) in Dielmo and for 16 years (1993-2
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Seifert, Elena. "Metabolic Changes in Pulmonary Arterial Smooth Muscle Cells Exposed to Increased Mechanical Forces from an Ovine Model of Congenital Heart Disease with Increased Pulmonary Blood Flow." Scholarship @ Claremont, 2019. https://scholarship.claremont.edu/cmc_theses/2094.

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An important cause of pulmonary arterial hypertension (PAH) in children with congenital heart disease (CHD) is increased pulmonary blood flow (PBF). To gain a better understanding of the disease process, the changes in biochemical pathways and metabolism of pulmonary arterial smooth muscle cells (PASMCs) were studied using a unique surgical ovine model of increased pulmonary blood flow. PASMCs isolated from 4-week-old lambs with increased PBF (shunt) showed lower oxygen consumption rates and lower extracellular acidification rates linked to glutamine metabolism when compared to controls. Shunt
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Samper, González Jorge Alberto. "Learning from multimodal data for classification and prediction of Alzheimer's disease." Electronic Thesis or Diss., Sorbonne université, 2019. http://www.theses.fr/2019SORUS361.

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La maladie d’Alzheimer (MA) est la première cause de démence dans le monde, touchant plus de 20 millions de personnes. Son diagnostic précoce est essentiel pour assurer une prise en charge adéquate des patients ainsi que pour développer et tester de nouveaux traitements. La MA est une maladie complexe qui nécessite différentes mesures pour être caractérisée : tests cognitifs et cliniques, neuroimagerie, notamment l’imagerie par résonance magnétique (IRM) et la tomographie par émission de positons (TEP), génotypage, etc. Il y a un intérêt à explorer les capacités discriminatoires et prédictives
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Tims, Steve. "A redemptive ministry to a family living with AIDS a project to recruit, train, and implement a care team in an effort to minister to a person living with AIDS and his family in the Wilshire Park Baptist Church /." Online full text .pdf document, available to Fuller patrons only, 2000. http://www.tren.com.

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Yates, Martin T. "Effect of ESC/EACTS guidelines on myocardial revascularisation on heart team discussion of patients with severe coronary artery disease in the United Kingdom." Thesis, St George's, University of London, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.675936.

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Joint European Society of Cardiology and European Association for Cardiothoracic Surgery (ESC/EACTS) Guidelines on Myocardial Revascularisation advocate Heart Team discussion of all patients with severe coronary artery disease. Furthermore, incomplete revascularisation is known to increase morbidity and mortality following intervention. The guidelines suggest that patients with left main stem, proximal LAD or three vessel disease (3VD) should be discussed with a surgeon prior to percutaneous coronary intervention (PCI). The aim of this project is to assess the impact of the guidelines on refer
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