Relevant bibliographies by topics / Diphenyl urea

Academic literature on the topic 'Diphenyl urea'

Author: Grafiati
Published: 9 March 2023

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Journal articles on the topic "Diphenyl urea"

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Wu, Yi-Cong, Xin-Yue Ren, and Guo-Wu Rao. "Research Progress of Diphenyl Urea Derivatives as Anticancer Agents and Synthetic Methodologies." Mini-Reviews in Organic Chemistry 16, no. 7 (October 8, 2019): 617–30. http://dx.doi.org/10.2174/1570193x15666181029130418.

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The malignant neoplasm, which is recognized as cancer, is a serious threat to human health and frequently-occurring disease. Diphenylurea, an important link structure in the design of active substance for treating cancer due to its near-perfect binding with certain acceptors, has demonstrated many activities against several human cancer cell lines. Various novel compounds with diphenyl urea as anticancer agents were constructed with the successful development of sorafenib. Diphenylurea is utilized to treat cancer by inhibiting cell signaling transduction, such as RAS-RAFMEK- ERK signaling pathway and PI3K-Akt-mTOR pathway. In addition, this structure inhibits tumor cell growth by inhibiting receptor tyrosine kinases multiply, such as Vascular Endothelial Growth Factor Receptors (VEGFRs), Platelet-Derived Growth Factor Receptors (PDGFRs), Epidermal Growth Factor Receptors (EGFRs). It regulates the pH value in cells by inhibiting CAIX/XII and to achieve cancer therapeutic effect. Besides, the diphenyl urea structure is applied to the synthesis of reagents like Aurora kinases inhibitors and HDAC inhibitors that affect cell division and differentiation to treat cancer. To reach the goal of treating tumor, this structure is also used as a DNA-directed alkylating agent by affecting the expression of genes. An application of the most representative diphenyl urea derivatives as antitumor agents is summarized in this review, focusing on their mechanisms bound to the targets. Meanwhile, the progress of researches on methods of synthesizing diphenyl urea derivatives is provided.
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Nguyễn, Thị Hồng Thắm, Đinh Châu Phan, Thị Hồng Thanh Nguyễn, Thị Xuân Thu Ngô, Thị Thủy Đặng, and Bình Dương Vũ. "SYNTHESIS OF MEMANTINE HYDROCHLORIDE BY DIRECT AMINOATION OF 1-BROMO-3,5-DIMETHYLADAMANTANE WITH." VietNam Military Medical Unisversity 47, no. 9 (December 1, 2022): 140–48. http://dx.doi.org/10.56535/jmpm.v47i9.214.

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Objectives: To optimize the synthesis process of memantine hydrochloride by direct aminoation of 1-bromo-3,5-dimethyladamantane with urea. Materials and methods: Using the basic chemical reactions to optimize the reaction conditions. Results: The optimal conditions of the memantine hydrochloride synthesis process include: The reaction solution was diphenyl ether; the reaction temperature was 170oC within 4 hours (in the first step) and 100oC within 2 hours (in the second step); the molar ration of 1-bromo-3,5-dimethyladmantane: urea: diphenyl ether was 1:3:2.5; the duration of the reaction was 6 hours and the overall yields were 75.81%. Conclusion: The synthesis process of memantine hydrochloride by direct aminoation with urea was established. The finished products were determined by IR, MS, and NMR spectra and met the standards of USP 43.
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Ferro, D., and G. Della Gatta. "Enthalpies of sublimation and fusion of monophenylurea and diphenyl-1,3 urea." Thermochimica Acta 122, no. 1 (December 1987): 189–95. http://dx.doi.org/10.1016/0040-6031(87)80119-3.

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Sallenave, X., S. Delbaere, S. Ahmed, G. Vermeersch, and J. L. Pozzo. "5-Ureido-3,3-diphenyl-3H-naphtho[2,1-b]pyrans: Photoswitchable self-assembling architectures." International Journal of Photoenergy 6, no. 4 (2004): 169–73. http://dx.doi.org/10.1155/s1110662x04000212.

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5-Ureido-3,3-diphenyl-3H-naphtho[2,1-b]pyrans have been synthesized and their photochromic properties have been quantified using UV-Visible spectroscopy. The urea pattern is responsive for the selfassembling properties under both colourless and coloured forms whereas the corresponding amino derivatives do not show any aggregative properties. The geometries of the different states have been assigned using1Hand19FNMR spectroscopies, and thereafter their respective kind of aggregates could be proposed through the different inter- and intramolecular interactions. Upon UV irradiation, the pyranic ring is opened and the resulting photogenerated carbonyl group is competing with the urea in the self-assembling process and consequently strongly affects the supramolecular assemblies. The inter- and intramolecular contributions have been quantified through 1D and 2D NMR experiments along with the variation in the concentration.
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Obiol-Pardo, Cristian, Gema Alcarraz-Vizán, Marta Cascante, and Jaime Rubio-Martinez. "Diphenyl Urea Derivatives as Inhibitors of Transketolase: A Structure-Based Virtual Screening." PLoS ONE 7, no. 3 (March 5, 2012): e32276. http://dx.doi.org/10.1371/journal.pone.0032276.

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Usha, Veeraraghavan, Sudagar S. Gurcha, Andrew L. Lovering, Adrian J. Lloyd, Athina Papaemmanouil, Robert C. Reynolds, and Gurdyal S. Besra. "Identification of novel diphenyl urea inhibitors of Mt-GuaB2 active against Mycobacterium tuberculosis." Microbiology 157, no. 1 (January 1, 2011): 290–99. http://dx.doi.org/10.1099/mic.0.042549-0.

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In contrast with most bacteria, which harbour a single inosine monophosphate dehydrogenase (IMPDH) gene, the genomic sequence of Mycobacterium tuberculosis H37Rv predicts three genes encoding IMPDH: guaB1, guaB2 and guaB3. These three genes were cloned and expressed in Escherichia coli to evaluate functional IMPDH activity. Purified recombinant Mt-GuaB2, which uses inosine monophosphate as a substrate, was identified as the only active GuaB orthologue in M. tuberculosis and showed optimal activity at pH 8.5 and 37 °C. Mt-GuaB2 was inhibited significantly in vitro by a panel of diphenyl urea-based derivatives, which were also potent anti-mycobacterial agents against M. tuberculosis and Mycobacterium smegmatis, with MICs in the range of 0.2–0.5 μg ml−1. When Mt-GuaB2 was overexpressed on a plasmid in trans in M. smegmatis, a diphenyl urea analogue showed a 16-fold increase in MIC. Interestingly, when Mt-GuaB orthologues (Mt-GuaB1 and 3) were also overexpressed on a plasmid in trans in M. smegmatis, they also conferred resistance, suggesting that although these Mt-GuaB orthologues were inactive in vitro, they presumably titrate the effect of the inhibitory properties of the active compounds in vivo.
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Vaishnav, Yogesh, Aloksingh Thakur, Chanchal Deep Kaur, Shekhar Verma, Achal Mishra, Sanmati Kumar Jain, and Piyush Ghode. "QSAR Analysis of some N, N-diphenyl urea derivatives as CCR5 Receptor Antagonist." Research Journal of Pharmacy and Technology 11, no. 9 (2018): 3802. http://dx.doi.org/10.5958/0974-360x.2018.00697.2.

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Du, Pengfei, Meiyin Wu, Xuanxuan Liu, Zhen Zheng, Xinling Wang, Thomas Joncheray, and Yuefan Zhang. "Diels-Alder-based crosslinked self-healing polyurethane/urea from polymeric methylene diphenyl diisocyanate." Journal of Applied Polymer Science 131, no. 9 (December 11, 2013): n/a. http://dx.doi.org/10.1002/app.40234.

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Guin, Akshya Kumar, Suryakanta Nayak, Manish Kumar Bhadu, Veena Singh, and Tapan Kumar Rout. "Development and Performance Evaluation of Corrosion Resistance Self-Healing Coating." ISRN Corrosion 2014 (April 23, 2014): 1–7. http://dx.doi.org/10.1155/2014/979323.

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Polymer based nanocapsule was developed using core-cell approach, where the core material was methyl diphenyl diisocyanate and the cell material was urea-formaldehyde. The synthesized capsules of 100 to 800 nm size were incorporated into sol-gel matrix to prepare a final coating for steel protection. This coating was found protecting the steel at the damage or crack locations in 3.5% NaCl solution. SEM micrographs confirmed healing of the coating at the damage or crack points.
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Hauback, Bj�rn C., Tor J. Brobak, Frode Mo, Astrid M. Schie Bergan, and Eva H. M�rkved. "Structure ofN, N?-diphenyl-N-(2-pyridmyl)urea hemihydrate: A crystallographic and spectroscopic investigation." Journal of Crystallographic and Spectroscopic Research 18, no. 6 (December 1988): 729–45. http://dx.doi.org/10.1007/bf01164294.

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Dissertations / Theses on the topic "Diphenyl urea"

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Cui, Zhiying. "Denim Fiberboard Fabricated from MUF and pMDI Hybrid Resin System." Thesis, University of North Texas, 2019. https://digital.library.unt.edu/ark:/67531/metadc1505281/.

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In this study, a series of denim fiberboards are fabricated using two different resins, malamine urea formaldehyde (MUF) and polymeric methylene diphenyl diisocyanate (pMDI). Two experimental design factors (1) adhesive content and (2) MUF-pMDI weight ratio, were studied. All the denim fiberboard samples were fabricated following the same resin blending, cold-press and hot-press procedures. The physical and mechanical tests were conducted on the fiberboard following the procedures described in ASTM D1037 to obtain such as modulus of elasticity (MOE), modulus of rupture (MOR), internal bond (IB), thickness swell (TS), and water absorption (WA). The results indicated that the MOE was significantly affected by both factors. IB was affected significantly by weight ratio of different glue types, with 17 wt% more MDI resin portion in the core layer of the denim boards, the IB for total adhesive content 15% fiberboard was enhanced by 306%, while for total adhesive content 25% fiberboard, enhanced by 205%. TS and WA, with higher adhesive content used in denim boards' fabrication, and more pMDI portion in the core layer of the boards, the boards' TS and WA was reduced by up to 64.2% and 78.8%, respectively.
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RAMADAN, DOAA REDA MOHAMED. "PALLADIUM CATALYZED REACTIONS: REDUCTIVE CYCLIZATION OF NITROARENES, AND OXIDATIVE CARBONYLATION OF ANILINE." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/819652.

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Palladium Catalyzed Reactions: Reductive Cyclization of Nitroarenes, and Oxidative Carbonylation of Aniline Abstract: The thesis is divided into two main chapters: reductive cyclization of nitroarenes, and oxidative carbonylation of aniline. The first chapter involves developing a catalytic system for carbazoles synthesis through reductive cyclization of 2-nitrobiphenyls employing phenyl formate as an in-situ source of CO. Thus, the synthetic chemist can avoid handling pressurized CO lines and perform the reaction in a pressure tube, a cheap and readily available tool for any laboratory. Moreover, the developed protocol can tolerate both air and moisture and can be performed using undried and undistilled commercial DMF. Several carbazoles bearing a wide range of substituents were synthesized in good to excellent yields including some with valuable pharmaceutical or thermo/electrical applications. The reaction could be performed on the grams scale affording carbazole in a very good yield (85%) without the need for chromatographic purification, making our synthetic strategy even more attractive and economically advantageous. The second chapter deals with the palladium/iodide couple which is the most investigated catalytic system for the oxidative carbonylation of amines to give ureas or carbamates. In reinvestigating it, we found that the most prominent role of iodide is to etch the stainless steel of the autoclave employed in most of previous works, releasing in solution small amounts of iron salts. The latter are much better promoters than iodide itself. Iron and iodide have a complex interplay and, depending on relative ratios, can even deactivate each other. The presence of a halide is beneficial, but chloride is better than iodide in this respect. The ideal Fe/Pd ratio is around 10, but even an equimolar amount of iron with respect to palladium (0.02 mol% with respect to aniline, corresponding to 12 ppm Fe with respect to the whole solution) is sufficient to boost the activity of the catalytic system. Such small amount may also come from Fe(CO)5 impurities present in the CO gas when stored in steel tanks. The role of the solvent has also been investigated. It was found that the reason for the better selectivity in some cases is at least in part due to a hydrolysis of the solvent itself, which removes the coproduced water.
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Capacci-Daniel, Christina Anne. "Crystal growth of polymorphic bis-diphenyl ureas on self-assembled monolayer templates." Connect to Electronic Thesis (CONTENTdm), 2009. http://worldcat.org/oclc/463440944/viewonline.

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