Relevant bibliographies by topics / Dingo Victoria / Journal articles

Journal articles on the topic 'Dingo Victoria'

To see the other types of publications on this topic, follow the link: Dingo Victoria.
Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Dingo Victoria.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Jones, Evan. "Hybridisation between the dingo, Canis lupus dingo, and the domestic dog, Canis lupus familiaris, in Victoria: a critical review." Australian Mammalogy 31, no. 1 (2009): 1. http://dx.doi.org/10.1071/am08102.

Full text
Abstract:
This paper reviews two separate population models proposed for a group of wild canids inhabiting the Victorian eastern highlands and re-analyses some of the data used. The first model was based upon two studies that used eight skull measurements in a canonical variate equation. Those studies classified population samples into three separate groups consisting of dingoes, feral domestic dogs and their hybrids. The second model, based upon a later study, classified a separate and additional population sample on the basis of both coat colour and physical appearance, but also cross-referenced the classifications to their canonical scores. That study rejected the model of three separate canid groups and the ability of the canonical variate equation to differentiate ‘pure’ dingoes from other canids. Instead the population was classified as a single group of dingo-like wild canids with an increased range in the variability of their physical characteristics compared to the original dingo population. After a re-evaluation of the data from the latter study and careful examination of the limitations of the canonical variate equation, the evidence presented here supports the population model of a single group of wild canids. Theoretical considerations associated with these two population models are discussed, as are the limitations of the canonical variate equation to classify the Victorian eastern highlands and other Australian wild canid populations.
APA, Harvard, Vancouver, ISO, and other styles
2

Robley, Alan, Andrew Gormley, David M. Forsyth, Alan N. Wilton, and Danielle Stephens. "Movements and habitat selection by wild dogs in eastern Victoria." Australian Mammalogy 32, no. 1 (2010): 23. http://dx.doi.org/10.1071/am09030.

Full text
Abstract:
To investigate movements and habitat selection by wild dogs we attached satellite-linked global positioning system (GPS) units to nine wild dogs (Canis lupus dingo and Canis lupus familiaris) captured in eastern Victoria in summer 2007. Units estimated locations at 30-min intervals for the first six months and then at 480-min intervals for six more months. DNA testing revealed all these wild dogs to be related. Home ranges of males were almost three times larger than those of females (males: 124.3 km2 ± 56.3, n = 4; females: 45.2 km2 ± 17.3, n = 5) and both sexes preferred subalpine grassland, shrub or woodland at the landscape and home-range scales. Wild dogs were recorded more often than expected within 25 m of roads and less often than expected within 25 m of watercourses. Wild dogs displayed higher-velocity movements with shallow turning angles (generally forwards) that connected spatial and temporal clusters comprising slower-velocity, shorter, and sharper turning movements. One wild dog travelled 230 km in 9 days before returning to its home range and another travelled 105 km in 87 days. The home-range sizes reported in this study are much larger than previously reported in south-eastern Australia. This finding, together with previous studies, suggests that the spatial scale at which wild dog management occurs needs to be reconsidered.
APA, Harvard, Vancouver, ISO, and other styles
3

Jones, E., and PL Stevens. "Reproduction in Wild Canids, Canis-Familiaris, From the Eastern Highlands of Victoria." Wildlife Research 15, no. 4 (1988): 385. http://dx.doi.org/10.1071/wr9880385.

Full text
Abstract:
Reproduction was studied in a group of wild canids collected over four years from the eastern highlands of Victoria. While births were recorded from March to September inclusive, 78% of them took place in the winter months of June-August, with the peak occurring in July. A single breeding season each year was indicated for most, with a mean prenatal litter size of 5.5 (range 2-9). Sexually mature males were fertile throughout the year, although they exhibited a significant increase in testes weight, epididymides weight, and number of active seminiferous tubules for the months of April-June, which corresponded to the peak period of oestrus in females. The onset of first oestrus in females was variable, occurring when they were 1-4 years old, with only 36% of those less than 2 years old sexually mature. Sexual maturity in males was also variable. For animals of 10 kg (weight at initial onset of spermatogenesis) or heavier, spermatogenesis had commenced in only 63% of those less than two years old, but increased to 97% of those more than three years old. Overall this sample of canids displayed reproductive characteristics, such as a seasonal breeding season, considered typical of dingoes. However the possibility of slight changes to the original dingo breeding patterns through hybridization with domestic dogs is discussed.
APA, Harvard, Vancouver, ISO, and other styles
4

Cahir, Fred (David), and Ian Clark. "The Historic Importance of the Dingo in Aboriginal Society in Victoria (Australia): A Reconsideration of the Archival Record." Anthrozoös 26, no. 2 (June 2013): 185–98. http://dx.doi.org/10.2752/175303713x13636846944088.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

García Villalba, Miriam. "«Discursos de la victoria. Modelos de legitimación literaria y cultural del franquismo», de Diego Santos Sánchez y Fernando Larraz (eds.)." Castilla. Estudios de Literatura, no. 13 (September 2, 2022): 773–76. http://dx.doi.org/10.24197/cel.13.2022.773-776.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Jackson-Martin, Charlie. "The violent-care of dingo conservation breeding." Animal Studies Journal 9, no. 2 (December 2020): 87–110. http://dx.doi.org/10.14453/asj/v9.i2.5.

Full text
Abstract:
In 2019, a wild-born dingo pup named Wandi was taken from the Victorian high country to the Australian Dingo Foundation to become a part of their breeding program. Wandi was chosen because he was identified as a ‘rare’ ‘alpine’ dingo. At the point at which Wandi was handed over to the ADF, he became a captive dingo and will likely never be released. Wandi is one of thousands of dingoes who are bred and sold each year by the dingo breeding industry in Australia – both for zoos and wildlife parks to exhibit, and as privately owned ‘pets’. None of these dingoes can ever be released. Dingo captivity is often justified by dingo breeders as a necessary part of ‘essential’ conservation to combat the possible ‘extinction’ of the dingo. In this article, I question this assumption and demonstrate how it perpetuates and energises historically constructed distinctions between dingo ‘types’ (such as ‘alpine’ and ‘pure’). Here, I mobilise Thom van Dooren’s concept of ‘violent-care’ to better understand the contradictory ways in which dingoes experience life and captivity in Australia: ‘rare’ but a ‘pest’, charismatic and newsworthy but also imprisoned, evincing popular sentiments of affection and forced into captive breeding. I work with these contradictions every day as the founder of Sydney Fox and Dingo Rescue (SFDR). As dingo advocates, we have a responsibility to examine the violence dingoes experience as a result of captivity and the ‘logics’ and discourse that drive that violence, as van Dooren writes: ‘[w]hen the ‘logics’ that structure violence (or care for that matter) go unexamined, they become both invisible and commonsensical’ (van Dooren, ‘A Day with Crows’ 3).
APA, Harvard, Vancouver, ISO, and other styles
7

Droppa, Alisson. "A complexidade do fenômeno da terceirização na perspectiva da América Latina." Mundos do Trabalho 7, no. 14 (June 28, 2016): 209. http://dx.doi.org/10.5007/1984-9222.2015v7n14p209.

Full text
Abstract:
http://dx.doi.org/10.5007/1984-9222.2015v7n14p209BASUALDO, Victoria; MORALES, Diego (Orgs). La tercerización laboral: orígenes, impacto y claves para su análisis en América Latina. 1ª ed. Buenos Aires: Siglo Veintiuno Editores, 2014.
APA, Harvard, Vancouver, ISO, and other styles
8

González Naranjo, Rocío. "VICTORINA DURÁN: POR UNA INSERCIÓN EN EL «MOVIMIENTO DE DRAMATURGAS REPUBLICANAS»." Acotaciones. Revista de Investigación y Creación Teatral 45 (December 18, 2020): 65–94. http://dx.doi.org/10.32621/acotaciones.2020.45.03.

Full text
Abstract:
If we take into account the theories about the concept of ge- neration —Julius Petersen, José Ortega y Gasset, Guillermo de Torre, Azorín, Pedro Salinas, Lorenzo Luzuriaga, Gerardo Diego, José Luís Cano, José Luís Aranguren to tell few names— and after what was re- leased in a previous issue (González, 2016) to the propose of a movement of republican playwrigts females, the goal of this research, owing to the recent edition of Victorina Durán’s anthology of inedit plays of vanguar- dist scenography, is to insert this last one into the list. Thus, we will apply the same premises that we already used previously with the other women playwrights to represent their validity in this emergent move- ment despite being forgotten. Nevertheless, we will constate Durán’s modernity thanks to her dramaturgics of lesbian thematic, something ground-breaking for a society that is not prepared to that yet.
APA, Harvard, Vancouver, ISO, and other styles
9

Glen, A. S. "Hybridisation between dingoes and domestic dogs: a comment on Jones (2009)." Australian Mammalogy 32, no. 1 (2010): 76. http://dx.doi.org/10.1071/am09031.

Full text
Abstract:
The recent review by Jones (2009) presents a strong argument that Victoria’s wild dog population cannot reliably be categorised into dingoes (Canis lupus dingo), feral dogs (C. l. familiaris) and hybrids. This presents a problem in the light of the dingo’s recent listing as a threatened species in that state. Wildlife managers must come to grips with questions regarding the relative conservation value of ‘dingoes’ with varying degrees of domestic dog ancestry. This will require improved knowledge of the ecological function of wild dogs, as well as extensive research into public attitudes towards the animals.
APA, Harvard, Vancouver, ISO, and other styles
10

Miyano, Masaru, Rosalyn W. Sayaman, Parijat Senapati, Stefan Hinz, Victoria E. Seewaldt, Dustin Schones, and Mark A. LaBarge. "Abstract A003: Integrating noise into a signal: Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility." Cancer Research 83, no. 2_Supplement_1 (January 15, 2023): A003. http://dx.doi.org/10.1158/1538-7445.agca22-a003.

Full text
Abstract:
Abstract This abstract is being presented as a short talk in the scientific program. A full abstract is available in the Short Talks from Proffered Abstracts section (PR006) of the Conference Proceedings. Citation Format: Masaru Miyano, Rosalyn W. Sayaman, Parijat Senapati, Stefan Hinz, Victoria E. Seewaldt, Dustin Schones, Mark A. LaBarge. Integrating noise into a signal: Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility [abstract]. In: Proceedings of the AACR Special Conference: Aging and Cancer; 2022 Nov 17-20; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2022;83(2 Suppl_1):Abstract nr A003.
APA, Harvard, Vancouver, ISO, and other styles
11

Rodríguez-Rodríguez, Ana M. "St. Francis Xavier—“Patrón desta jornada”: Jesuit Writings and the Spanish Re-Appropriation of the Pacific." Journal of Jesuit Studies 9, no. 2 (January 18, 2022): 229–44. http://dx.doi.org/10.1163/22141332-09020004.

Full text
Abstract:
Abstract The figure of St. Francis Xavier was a tool used in Spanish texts as an instrument to increase the prestige and dissemination of colonial endeavors. In the seventeenth century, amidst the tense rivalry between the Spanish and the Portuguese empires, several Jesuit writings take a stand in support of the Spanish monarchy’s interests in Asia, reinforcing the legitimacy of its conquests and the appropriateness of Spain’s intervention in the area. This article studies two of these texts: Diego de Bobadillas’s Relación de las gloriosas victorias and Diego Calleja’s San Francisco Javier, el Sol en Oriente, focusing on the textual strategies employed in them to vindicate the fight against Muslims in the Philippines and the wider Spanish intervention in the Pacific through the celebration of St. Francis’s endeavors.
APA, Harvard, Vancouver, ISO, and other styles
12

Addison, Catherine. "THE VICTORIAN VERSE NOVEL AS BESTSELLER: OWEN MEREDITH'SLUCILE." Victorian Literature and Culture 45, no. 2 (May 5, 2017): 257–74. http://dx.doi.org/10.1017/s1060150316000607.

Full text
Abstract:
By the 1860s, the versenovel had become a significant feature of the Victorian literary landscape. According to Dino Felluga, this hybrid was a “perverse” and even “subversive” genre, firstly, because it undermined the “‘high’ autotelic” status of poetry by mixing it with the “heteroglot, carnivalesque, and polyphonic novel” and, secondly, because its specific fictions tended to oppose or parody the “middle-class heterosexual, domestic ideology” upheld by the prose novel of the period. In support of his argument, Felluga discusses a handful of texts that are normally regarded as “high” literature: Elizabeth Barrett Browning'sAurora Leigh, Arthur Hugh Clough'sAmours de Voyage, George Meredith'sModern Loveand Robert Browning'sThe Ring and the Book(Felluga, “Verse Novel” 171–74; “Novel Poetry” 491–96).
APA, Harvard, Vancouver, ISO, and other styles
13

Peng, Haitao, and Ignacio Ramos Riera. "Traducción de los prefacios a Las siete victorias (Qike) de Diego de Pantoja (1571-1618)." Hispania Sacra 74, no. 150 (December 30, 2022): 483–94. http://dx.doi.org/10.3989/hs.2022.34.

Full text
Abstract:
El Tratado de las siete victorias (1614) de Diego de Pantoja (1571-1618), abreviado Qike, es la primera exposición sistemática escrita en lengua china de la tradición moral de Occidente dirigida a las élites intelectuales confucianas, y en general una obra magna de la literatura intercultural. El presente estudio traduce los prefacios preparados tanto por Pantoja como por una serie de eruditos chinos y comenta textos nunca antes vertidos a otra lengua. Estos textos constituyen un testimonio inédito de diálogo filosófico y humanístico en el tiempo de la primera globalización de corte iberoamericano.
APA, Harvard, Vancouver, ISO, and other styles
14

Matthews, Thomas G. "Toward a Prototypical Model of Culture for Bible Translation." Journal of Translation 5, no. 1 (2009): 1–61. http://dx.doi.org/10.54395/jot-nxjwk.

Full text
Abstract:
Bible translation is inherently a communication event originating in a historical language and culture. Recipients of translated Scriptures interpret this historical text through their language and cultural grid. They have cultural practices, material culture, beliefs, values, a worldview, image schemas, etc., that can assist or compromise their ability to properly understand the Bible. This work addresses the challenge to translators and translation consultants to more readily identify translation issues that are rooted in the target culture such that they may be further researched and treated as appropriate in the translation and helps. A prototypical model of culture is proposed to support these deliberations, which is comprised of a stratified network of observable cultural systems, beliefs, values, and deep structural components of worldview and image schemas. The cultural model is productively applied to a survey of translation issues rooted in the target cultures of several language teams in eastern Africa, and to three, in-depth analyses from Zinza and Digo Scriptures. The results suggest that Zinza prefer LINK and PATH image schemas over IN/OUT and FULL/EMPTY CONTAINER image schemas in metaphorical extensions such as “in Christ.” In addition, the Digo people’s limited knowledge of biblical construction practices, and the strong impact of the Lake Victoria ecosystem on Zinza culture, present translation challenges to the Digo New Testament and Zinza Genesis, respectively.
APA, Harvard, Vancouver, ISO, and other styles
15

Kumar, Devaprashanth Mohan, and Sindhu Sivakumar. "Evaluation of the role of pre-operative albumin and its post-operative drop in the prediction of outcomes of emergency laparotomy." International Surgery Journal 7, no. 4 (March 26, 2020): 1234. http://dx.doi.org/10.18203/2349-2902.isj20201390.

Full text
Abstract:
Background: Laparotomies are commonly performed surgeries in an emergency setting. The complications associated with these are a result of the activation of the surgical stress response, the magnitude and duration of which are proportional to the surgical injury. Albumin is an important negative phase reactant. This study was an attempt to evaluate the effectiveness of measurement of pre-operative albumin and the post-operative drop in albumin levels in the prediction of post-operative morbidity and mortality following laparotomy.Methods: Albumin levels of 50 patients undergoing emergency exploratory laparotomy in Victoria Hospital were measured pre and post operatively. The percentage drop in albumin levels was noted. The outcomes were noted and classified according to Clavein Dindo Classification. Unpaired t-test and ANOVA test was used for statistical analysis. A p value of <0.05 was considered statistically significant.Results: 62% of the patients had hypoalbuminemia preoperatively. 58% of patients had post-operative complications. The mean preoperative albumin levels for patients without complications was 3.83 while that for patients with complications was 2.78 (p<0.05). The mean percentage drop in albumin values was 9.66% for patients without complications while it ranged from 14.79 (Clavein Dindo 1) - 24.27 (Clavein Dindo 5) for patients with complications (p=0.047). A negative correlation was noted between the preoperative albumin values and the duration of hospital stay while the drop in albumin levels showed a positive correlation with the duration of hospital stay.Conclusions: Measurement of albumin levels pre-operatively and in the immediate post-operative period following laparotomy can prove as a useful tool and an early indicator of morbidity and mortality following laparotomy.
APA, Harvard, Vancouver, ISO, and other styles
16

Alfaro-Ávila, Miguel Ángel, Iván Pérez-Neri, and Carlos Eduardo Diéguez-Campa. "A Water Baby ¿Meningoencefalitis parasitaria?" Archivos de Neurociencias 23, no. 3 (May 17, 2020): 28–31. http://dx.doi.org/10.31157/an.v23i3.15.

Full text
Abstract:
Las enfermedades neurológicas han sido plasmadas en el arte a lo largo de la historia. Desde la cultura egipcia hasta médicos contemporáneos han representado dichas enfermedades en sus obras. Herbert James Draper fue un pintor clasista de la época victoriana que centró su trabajo en temática de la mitología de la antigua Grecia; entre sus obras más destacadas de encuentran ‘Lament for Icarus’, ‘Ulysses and the Sirens’ y ‘A Water baby’; esta última tiene un peculiar hallazgo semiológico. La actitud en la que se encuentra el infante hace referencia a un síndrome de irritación meníngea y el contexto sugiere una etiología parasitaria, digno de un análisis clínico.
APA, Harvard, Vancouver, ISO, and other styles
17

Alfaro-Ávila, Miguel Ángel, Iván Pérez-Neri, and Carlos Eduardo Diéguez-Campa. "A Water Baby ¿Meningoencefalitis parasitaria?" Archivos de Neurociencias 23, no. 3 (May 17, 2020): 28–31. http://dx.doi.org/10.31157/archneurosciencesmex.v23i3.15.

Full text
Abstract:
Las enfermedades neurológicas han sido plasmadas en el arte a lo largo de la historia. Desde la cultura egipcia hasta médicos contemporáneos han representado dichas enfermedades en sus obras. Herbert James Draper fue un pintor clasista de la época victoriana que centró su trabajo en temática de la mitología de la antigua Grecia; entre sus obras más destacadas de encuentran ‘Lament for Icarus’, ‘Ulysses and the Sirens’ y ‘A Water baby’; esta última tiene un peculiar hallazgo semiológico. La actitud en la que se encuentra el infante hace referencia a un síndrome de irritación meníngea y el contexto sugiere una etiología parasitaria, digno de un análisis clínico.
APA, Harvard, Vancouver, ISO, and other styles
18

Falguera-García, Enric. "Alicia en el laberinto intertextual: del hipertexto a la pantalla." Ocnos: Revista de estudios sobre lectura 18, no. 2 (July 29, 2019): 65–74. http://dx.doi.org/10.18239/ocnos_2019.18.2.1891.

Full text
Abstract:
Este artículo pretende analizar el carácter intertextual de una obra clásica de la literatura infantil y juvenil como es la novela de Lewis Carroll, Alicia en el país de las maravillas. El trabajo presentado consiste en un primer apartado de introducción sobre las nociones teóricas de hipertextualidad e intertextualidad. Posteriormente, nos adentraremos en el análisis de la novela victoriana como ejemplo de texto hipertextual desde dos vertientes: por un lado el concepto de literatura dentro de la literatura que se da en la novela y por otro lado analizaremos las relaciones intertextuales que se producen entre el texto de Carroll y otras obras literarias y audiovisuales tales como la versión cinematográfica de Tim Burton o la novela de Diego Arboleda, Prohibido leer a Lewis Carroll. Finalmente, valoraremos las relaciones de Alicia con textos hipermodales, que permiten comprender mejor la novela decimonónica y ampliar el horizonte de expectativas del lector.
APA, Harvard, Vancouver, ISO, and other styles
19

Emerson, Joanne B., Brian C. Thomas, Karen Andrade, Eric E. Allen, Karla B. Heidelberg, and Jillian F. Banfield. "Dynamic Viral Populations in Hypersaline Systems as Revealed by Metagenomic Assembly." Applied and Environmental Microbiology 78, no. 17 (July 6, 2012): 6309–20. http://dx.doi.org/10.1128/aem.01212-12.

Full text
Abstract:
ABSTRACTViruses of theBacteriaandArchaeaplay important roles in microbial evolution and ecology, and yet viral dynamics in natural systems remain poorly understood. Here, we createdde novoassemblies from 6.4 Gbp of metagenomic sequence from eight community viral concentrate samples, collected from 12 h to 3 years apart from hypersaline Lake Tyrrell (LT), Victoria, Australia. Through extensive manual assembly curation, we reconstructed 7 complete and 28 partial novel genomes of viruses and virus-like entities (VLEs, which could be viruses or plasmids). We tracked these 35 populations across the eight samples and found that they are generally stable on the timescale of days and transient on the timescale of years, with some exceptions. Cross-detection of the 35 LT populations in three previously described haloviral metagenomes was limited to a few genes, and most previously sequenced haloviruses were not detected in our samples, though 3 were detected upon reducing our detection threshold from 90% to 75% nucleotide identity. Similar results were obtained when we applied our methods to haloviral metagenomic data previously reported from San Diego, CA: 10 contigs that we assembled from that system exhibited a variety of detection patterns on a timescale of weeks to 1 month but were generally not detected in LT. Our results suggest that most haloviral populations have a limited or, possibly, a temporally variable global distribution. This study provides high-resolution insight into viral biogeography and dynamics and it places “snapshot” viral metagenomes, collected at a single time and location, in context.
APA, Harvard, Vancouver, ISO, and other styles
20

Frable, Benjamin, Charlotte Seid, Greg Rouse, and Philip Hastings. "Integration and Curation of At-Risk Collections into the Scripps Institution of Oceanography Collections." Biodiversity Information Science and Standards 2 (June 13, 2018): e26259. http://dx.doi.org/10.3897/biss.2.26259.

Full text
Abstract:
The Scripps Institution of Oceanography (SIO) at the University of California, San Diego maintains one of the largest combined oceanographic collections in the world comprising four collections: Geological (sediment cores and dredged rocks), Pelagic Invertebrates, Benthic Invertebrates and Marine Vertebrates. After surviving threats of dissolution, the SIO Collections are now securely funded and have been able to make other collections available to the scientific community. Over the last few years, both the Marine Vertebrate (SIO-MVC) and Benthic Invertebrate (SIO-BIC) Collections have received National Science Foundation (NSF) and institutional funding to integrate important at-risk collections from University of California, Los Angeles (UCLA), the Monterey Bay Aquarium Research Institute (MBARI) and the University of Victoria. The UCLA Ichthyological Collection, around 9000 lots, was at risk of disposal due to hazardous material concerns and lack of institutional support. The collection, accumulated primarily under Boyd Walker (1949-1980) and later Don Buth (1980-), contains material from extensive surveys of the near-shore fishes of Southern California, Baja California and the Tropical Eastern Pacific including remote oceanic islands such as the Revillagigedos, Clipperton and the Galapagos. The UCLA collection also contains over 150 secondary types and over 100 species new to the SIO-MVC. Due to lack of support, the collection records were never digitized and the collection was minimally curated and its holdings were poorly known. For over two years, the collection manager and student employees have physically re-curated and integrated this material into the SIO-MVC. These data are now available online via iDigBio and VertNet and have already been used in numerous studies. The SIO-BIC, holding 45,000 lots, is accepting ownership of two deep-sea animal collections from Verena Tunnicliffe at the University of Victoria and Robert Vrijenhoek at MBARI. These collections include 10,900+ lots, largely from hydrothermal vents across the Pacific. Collected over 35 years from remote deep-sea sites that are difficult and expensive to access, these collections represent a major resource for systematics, genetics, and ecology. With Dr. Vrijenhoek now retired and Dr. Tunnicliffe nearing retirement, their collections were at risk of being lost. This material will be made discoverable online through the SIO-BIC database and iDigBio, and will be available for loan and examination. In the last year, the collection manager and five undergraduate employees have integrated some 3,000 lots. With support from the institution and the NSF, the SIO collections are solidifying their roles as central repositories for deep-sea and Eastern Pacific fauna.
APA, Harvard, Vancouver, ISO, and other styles
21

Residentes, Residentes. "Cardiología." Acta Médica Colombiana 43, no. 2S (June 24, 2019): 27–54. http://dx.doi.org/10.36104/amc.2018.1393.

Full text
Abstract:
C-1. DISMINUCIÓN DE LA MORBIMORTALIDAD EN FALLA CARDIACA, MEJORÍA DE LA FRACCIÓN DE EYECCIÓN Y CLASE FUNCIONAL CON EL USO DE SACUBUTRILO / VALSARTAN (PEÑA QUINTERO HAROLD, KOGA CORREA JENNY CAROLINE, TASCON GUEVARA BRIGITTE NATHALIA C-2. CORAZÓN CARCINOIDE Y TUMOR NEUROENDOCRINO METASTÁSICO (AGUDELO CARLOS, TRUJILLO DANILO, LUNA FREDY, ORTIZ CARLOS, GUERRA JOAQUÍN.) C-3. DEXTROCARDIA ADQUIRIDA (AVILA NATALIA, CELEMIN CARLOS, VARGAS JUAN GUILLERMO) C-4. ENDOCARDITIS INFECCIOSA EN VÁLVULA PROTÉSICA AORTICA POR STREPTOCOCCUS GORDONII (NAVARRETE LINDA, FUENTES CARLOS, ÁLVAREZ CAMILO, RESTREPO CARLOS, SUPELANO MARIO, MORA JAVIER) C-5. COMPROMISO CARDÍACO EN AMILOIDOSIS (BETANCUR SALAZAR KELLY JOHANNA, RONDÓN CARVAJAL JULIÁN FELIPE, THORRENS RÍOS JOSE GREGORIO) C-6. INSUFICIENCIA TRICUSPIDEA PRIMARIA ASOCIADA A INSUFICIENCIA CARDIACA DERECHA, LA VÁLVULA OLVIDADA (MENDOZA FERNÁN, ROMERO JOSÉ, LONDOÑO GABRIEL, IDROVO CAROLINA, MENDOZA LAURA VICTORIA, NÚÑEZ FEDERICO, CAICEDO VÍCTOR) C-7. COMUNICACIÓN INTERVENTRICULAR COMO COMPLICACIÓN TEMPRANA POST INFARTO DE CARA ANTERIOR (MENDOZA FERNÁN, LONDOÑO GABRIEL, CASTAÑO ANGIE MARCELA, MENDOZA LAURA VICTORIA, ANDRADE DARÍO, FEDERICO NÚÑEZ, CAICEDO VÍCTOR C-8. COMPLICACIONES CARDIOVASCULARES DEL CONSUMO DE COCAÍNA (SANTAMARIA ALZA YEISON, HERNANDEZ CELIS ANNIE) C-9. PERFIL CLÍNICO Y DEMOGRÁFICO DE PACIENTES CON FALLA CARDIACA AGUDA. ANÁLISIS DESCRIPTIVO DE COHORTE. (JUAN EMILIO, AMAYA NICOLAS, JUAN MARIETTA, ARBELAEZ LINA, CALVO LAUREN, VALENCIA MARGARITA, MARIÑO ALEJANDRO, GARCIA-PEÑA ANGEL) C-10. ABSCESO AÓRTICO PERIPROTÉSICO ROTO (CACERES EDWARD, JUAN MARIETTA, OSPINA DIEGO, MOLINA GERMAN, RIOS GIOVANNY, GARCIA-PEÑA ANGEL) C-11. MIOCARDITIS Y PUENTE MUSCULAR: ASOCIACIÓN CON MANIFESTACIONES SEMEJANTES AL SINDROME CORONARIO (MENDOZA FERNÁN, MORALES MILENA) C-12. INSUFICIENCIA CARDIACA AVANZADA, DIABETES Y CIRROSIS COMO MANIFESTACIONES DE UN CASO DE HEMOCROMATOSIS HEREDITARIA (MENDOZA FERNÁN, ORTIZ PAOLA, MEDINA OSCAR, JARAMILLO CLAUDIA, ARIZA GERARDO) C-13. RELACIÓN ENTRE EL RESULTADO DE TROPONINA CARDÍACA Y LA MORTALIDAD EN UN HOSPITAL DE SEGUNDO NIVEL DE ATENCIÓN (ARAUJO DURAN JORGE, CONCHA DIANA, BARROS CAMILO) C-14. COMPARACIÓN DE ESCALAS DE PREDICCIÓN DE RIESGO EN DOLOR TORÁCICO, EN UN HOSPITAL DE ALTA COMPLEJIDAD (TORRALBA ADRIÁN FELIPE, NAVARRO ALBERTO, ORTIZ CARLOS) C-15. MIOCARDIOPATIA DILATADA PERIPARTO: PRESENTACION DE UN CASO (GRANELA KATYA, BROCHADO LEONARDO) C-16. PROTOCOLOS ADAPT VS HEART EN EL DIAGNÓSTICO DEL DOLOR TORÁCICO: DISEÑO DE UN ENSAYO CLÍNICO ALEATORIZADO PRAGMATICO (SPROCKEL JOHN*, DIAZTAGLE JUAN*, CHAVES WALTER, ALVAREZ JOHAN, BOHORQUEZ JUAN, HURTADO EDUARDO, HERRERA GEOBER, ALZATE JUAN, OLAYA ALEJANDRO) C-17. AGENESIA DE ARTERIA PULMONAR UNILATERAL EN ADULTO CON TETRALOGÍA DE FALLOT (CASTRO LEIDY, CÁRDENAS LAURA, SPROCKEL JOHN) C-18. PERICARDITIS CONSTRICTIVA POR TUBERCULOSIS REPORTE DE CASO CLINICO (GONZÁLEZ YESENIA, ARTETA SHEILA) C-19. UTILIDAD DIAGNOSTICA DEL SIGNO DE FRANK EN PACIENTES CON ENFERMDEDAD CARDIOVASCULAR ATENDIDOS EN UN HOSPITAL DE TECER NIVEL (ÁLVAREZ LUIS, BURITICÁ WILSON, CALDERÓN LAURA, LOSADA MARÍA, MACÍAS DANIELA, VERGARA JHON) C-20. EXPERIENCIA EN CATETERISMO CARDIACO DERECHO EN PACIENTES CON SOSPECHA DE HIPERTENSION PULMONAR EN EL HOSPITAL GENERAL DE MÉXICO (JURADO YAMILE, CUETO GUILLERMO, GÓMEZ SAMUEL) C-21. COMPARACIÓN DE RESULTADOS DE ECOCARDIOGRAMA ESTRÉS Y PRUEBA DE ESFUERZO EN PACIENTES DE CONSULTA ESPECIALIZADA (YASNÓ NAVIA PAOLA ANDREA, LÓPEZ GARZÓN NELSON ADOLFO, MARIA VIRGINIA PINZÓN) C-22. ANGIOGRAFÍA CORONARIA: HALLAZGOS Y PERFIL CLÍNICO EN 100 PACIENTES EN LA UNIDAD DE HEMODINAMIA DE UN CENTRO DE REFERENCIA CARDIOVASCULAR, REPORTE PRELIMINAR (DURAN GUTIÉRREZ LUIS FERNANDO, ALVAREZ ROSERO RAFAEL ALBERTO, JIMÉNEZ CANIZALES CARLOS EDUARDO, PEÑA MURCIA ANGIE DANIELA, VARGAS RIVEROS LUIS FERNANDO, SANTOS POLANCO LUIS FERNANDO, MONDRAGÓN CARDONA ÁLVARO EDUARDO) C-23. HEMANGIOMA CARDIACO DEL NODO AURICULOVENTRICULAR (HERNÁNDEZ JENIFFER, PINTO DIEGO C-24. SÍNDROME DE KOUNIS INDUCIDO POR N-ACETIL CISTEÍNA (PIZZA RESTREPO MARIA JULIANA, ÁLVAREZ MORENO ADRIANA, OCAMPO YEPES MARIA CAMILA, CEBALLOS ZAPATA KATHERINE, THORRENS RIOS JOSE GREGORIO) C-25. CARACTERIZACIÓN DE LA POBLACIÓN CON ENDOCARDITIS INFECCIOSA EN EL HOSPITAL DEPARTAMENTAL SANTA SOFÍA DE CALDAS ENTRE EL 2012-2016 (BECERRA LUZ YANETH, GARCÍA CRISTIAN, SÁNCHEZ FABIO MAURICIO) C-26. TUMORES CARDIACOS PRIMITIVOS BENIGNOS: MIXOMA CUYA PRESENTACIÓN CLÍNICA FUE UN SÍNDROME CORONARIO AGUDO (MENDOZA FERNÁN, GUTIÉRREZ FELIPE, LONDOÑO GABRIEL, QUINTERO JUAN, ROMERO JOSÉ, VEGA IVÁN, MENDOZA LAURA, NÚÑEZ FEDERICO, ANDRADE DARÍO, CAICEDO VÍCTOR) C-27. DERRAME PERICARDICO COMO MANIFESTACIÓN DE MALARIA COMPLICADA (GÓMEZ PACHÓN CAMILO ANDRÉS, CRIOLLO VARÓN KEVIN LEANDRO, FIGUEROA CRISTIAN, TORRES DAVID, DUQUE RUBÉN, PÉREZ FRANCO JAIRO ENRIQUE.) C-28. PERICARDITIS POSTINFARTO ASOCIADO A HEMOPERICARDIO Y TAPONAMIENTO CARDIACO (RAMIREZ GARCIA MONICA, CORREA ALDANA JOHN JAIRO, PUENTES CASTRILLON MARIA ELCY, FIERRO RODRIGUEZ DORA EMILIA, DOMINGUEZ RUIZ JUAN DIEGO)
APA, Harvard, Vancouver, ISO, and other styles
22

Franco Martínez, José Ramón Pascual, Andrés González Huerta, Delfina De Jesús Pérez López, and Manuel González Ronquillo. "Caracterización fenotípica de híbridos y variedades de maíz forrajero en Valles Altos del Estado de México, México." Revista Mexicana de Ciencias Agrícolas 6, no. 8 (November 15, 2017): 1915. http://dx.doi.org/10.29312/remexca.v6i8.529.

Full text
Abstract:
En México, la aplicación de la selección e hibridación han generado maíces de mayor producción de grano y los criollos se usan con doble propósito pero existe escasa información sobre su potencial para desarrollar materia verde y seca. Este estudio se realizó en 2013 para identificar cultivares forrajeros sobresalientes para el Valle Toluca-Atlacomulco, México. 29 cultivares fueron evaluados en campo bajo un diseño experimental de bloques completos al azar con tres repeticiones por sitio. El análisis de los datos a través de las cuatro localidades se hizo como una serie de experimentos en espacio. Los resultados más importantes mostraron que las mejores localidades para la evaluación del material genético fueron Metepec y Tiacaque. Los cultivares Victoria, H-159 y SBA-470 constituyeron la fracción superior de los programas de hibridación obtenidos a partir de metodologías convencionales y los Amarillos Allende, San Cayetano y Portes Gil, Cacahuacintles Tlacotepec y San Cristóbal y Blancos Tlacotepec y San Diego representan la obra artística y cultural de los agricultores mexiquenses que, por medio de selección masal visual aplicada a las dimensiones de la mazorca y de la planta, han incrementado el potencial productivo de grano y forraje. Las mayores producciones en forraje verde y seco que se obtuvieron en el material genético más sobresaliente se explican por aumentos significativos en número de hojas por planta, floración masculina, altura de planta, y producciones de materia verde y seca de elote, tallos y hojas. Los cultivares más sobresalientes podrían emplearse para derivar líneas endogámicas y formar nuevas variedades e híbridos forrajeros o destinarse a un programa de aplicación, validación o generación de tecnología agropecuaria.
APA, Harvard, Vancouver, ISO, and other styles
23

McCleary, John. "Euclid Unseated: Mathematical Visions . The Pursuit of Geometry in Victorian England. Joan L. Richards. Academic Press, San Diego, CA, 1988. xiv, 266 pp., illus. $34.95." Science 246, no. 4932 (November 17, 1989): 940. http://dx.doi.org/10.1126/science.246.4932.940.a.

Full text
APA, Harvard, Vancouver, ISO, and other styles
24

Gessner, Ingrid, Miriam Nandi, and Juliane Schwarz-Bierschenk. "MatteRealities: Historical Trajectories and Conceptual Futures for Material Culture Studies." Open Cultural Studies 3, no. 1 (January 1, 2019): 308–16. http://dx.doi.org/10.1515/culture-2019-0027.

Full text
Abstract:
Abstract “No ideas but in things!” William Carlos Williams’s leitmotif for the modernist epic Paterson seems to anticipate the current renewal of academic attention to the materialities of culture: When the Smithsonian Institution accounts for The History of America in 101 Objects (Kurin) or when Neil MacGregor, designated director of the Humboldt Forum in Berlin, aims at telling The History of the World in 100 Objects (2011), they use specimens of material culture as register and archive of human activity. Individual exhibitions explore the role of objects in movements for social and political change (Disobedient Objects, Victoria and Albert Museum, London). Large-scale national museum projects like the new Humboldt Forum in Berlin or the National Museum of African American History and Culture in Washington, D.C., draw attention to the long existence of collections in Western institutions of learning and reveal the inherently political character of material culture—be that by underscoring the importance of institutional recognition of particular identities or by debates about provenance and restitution of human remains and status objects. The plethora of objects assembled in systematic as well as idiosyncratic collections within and outside the university is just beginning to be systematically explored for their roles in learning and education, funded by national research organizations such as the German BMBF.1 In theatrical performances, things function as discussion prompts in biographical work (Aufstand der Dinge, Schauspielhaus Chemnitz) or unfold their potential to induce a bodily experience (The Force of Things: An Opera for Objects, GK Arts Center, Brooklyn, NY). Things are present: as heritage, as commodities, as sensation; they circulate in processes of cognition and mediation, they transcend temporal and spatial distantiations. Things figure in narration and performance, in our everyday life practices, in political activism. They build knowledge of ourselves and others, influence the ways in which we interact with our fellow human beings, and in which we express or control our feelings. They combine the apparently concrete and the fleetingly abstract. Overall, things make us do things.
APA, Harvard, Vancouver, ISO, and other styles
25

Jacob, James. "Rethinking Te Aro in the 1910s." Architectural History Aotearoa 14 (August 17, 2022): 47–53. http://dx.doi.org/10.26686/aha.v14i.7792.

Full text
Abstract:
Wellington's Te Aro neighbourhood is particularly notable for both its broad expanse of relatively flat land and for its rectilinear grid of streets and associated superblocks in a city otherwise known for its hills and irregular road system. Over the course of the nineteenth-century after the start of European settlement in 1840, the town acres within the superblocks of Te Aro were more intensively developed in myriad ways, resulting in a haphazard arrangement of worker dwellings, commercial premises, and industrial outfits aligned along largely private lanes and alleys. With the notable exception of the street grid, nearly all vestiges of this initial, Victorian-era development were progressively destroyed during the twentieth century. Although most of the architectural and urban reinvention of Te Aro did not occur until the decades following World War II, acknowledgment of the major factors that would ultimately contribute to this process - traffic congestion, the low quality of the existing building stock, and a strong shift away from residential functions - became more and more emphasised during the 1910s. A writer for the Evening Post in 1913 imagined the neighbourhood just seven years in the future: "the dingy wooden boxes on Te Aro Flat will have given place to handsome warehouses and shops and factories …The problem of traffic, already threatening trouble … is certainly a task for the ablest engineer nowadays to suggest a way out" (Autos "The Future" p 3). This degree of optimism for rapid change was quickly tempered by the realities of world war and, in retrospect, the 1910s can be interpreted as a period of incubation for ideas about architecture urban planning in Te Aro that would only come to fruition later in the century.
APA, Harvard, Vancouver, ISO, and other styles
26

Monteiro Pereira, Wagner. "Traducción de épica burlesca: La Gatomaquia de Lope de Vega." Belas Infiéis 9, no. 2 (March 30, 2020): 65–82. http://dx.doi.org/10.26512/belasinfieis.v9.n2.2020.26995.

Full text
Abstract:
Este artículo propone una breve introducción al poema épico-burlesco de Félix Lope de Vega, La Gatomaquia (1634), obra aún secundaria en los estudios lopeanos, cuya extensa bibliografía se detiene antes en la producción dramática del autor. Dos cuestiones centrales se destacarán a lo largo de este trabajo: la primera se refiere a la elección de Lope de Vega por un género burlesco para finalizar su producción épica, tras haber publicado poemas largos que intentaban construir en España un imaginario de una historia victoriosa, como Luis de Camões había hecho en Portugal con Os Lusíadas (1572). Sin embargo, no tenía la intención de proponer un proyecto innovador como había hecho con El arte nuevo de hacer comedias (1609) que intentaba dar cuenta de un nuevo modelo de comedia que se consolidaba en España. Al contrario, Lope explicita su inserción dentro de una tradicción cuyos nombres de Marción de Sinope, Diego Hurtado de Mendoza y, especialmente, Homero, se muestran fundamentales para la composición de este poema de carácter jocoso. Este estudio pretende analizar, por lo tanto, las referencias presentes en el poema y el alcance del género burlesco en la literatura española. La segunda cuestión tiene relación con el alcance aún exiguo de la poesía épica española en Brasil, lo que propicia la propuesta de una tradición comentada del poema del castellano al portugués, con el fin de impulsar la literatura española del XVII en países de habla portuguesa. Dentro de este panorama, será relevante presentar un pequeño esbozo de las vertientes teóricas de traducción en diferentes siglos por España, con especial destaque a las primeras escuelas de traducción, que surgieron en el siglo XVI español en Sevilla y Toledo.
APA, Harvard, Vancouver, ISO, and other styles
27

Jules-Rosette, Bennetta, and Robert Cancel. "Introductory Remarks on African Humanities." African Studies Review 29, no. 1 (March 1986): 1–2. http://dx.doi.org/10.1017/s0002020600011665.

Full text
Abstract:
This issue of the African Studies Review is devoted to research in the African humanities. The appearance of new approaches to the study of literary texts, oral traditions, and the popular arts has inspired us to assemble this collection. Recently, the African humanities have been neglected as an important area in which new empirical and theoretical advances have been made for the study of oral texts, art, and performance.The articles in this collection by Robert Cancel, David Coplan, Bennetta Jules-Rosette, and V. Y. Mudimbe were presented at the Conference on Popular Arts and the Media in Africa held at the University of California, San Diego from May 17-19, 1982. This conference was sponsored by the Joint Committee on African Studies of the Social Science Research Council and the American Council of Learned Societies. We would like to thank the Joint Committee for their support of this conference and our initial efforts to develop a research synthesis for the African humanities.This collection begins with V. Y. Mudimbe's commentary on the nature of African art and the limitations of research models used to study it. He questions the role and position of African arts, especially visual arts, in the post-colonial world. He suggests that the time has passed where most of these works can be judged simply as self-enclosed cultural referents, isolated from the effects of the last two hundred years of history. The process of “aesthetization” that he describes is one which, in various transformations, informs each of the papers that follow. When Fanon suggested that to take on a language is to “take on a world,” he foreshadowed the ideas that acknowledge the development of Africa's humanities in a context of cultural interchange with other world traditions. This is not to accept the Victorian pronouncements that credited all African achievements to various forms of Western influence. Rather, it is a movement towards the view that African culture, always fluid and dynamic, has been responsive to all manner of influences, both local and foreign.
APA, Harvard, Vancouver, ISO, and other styles
28

Cao, Zhiyuan, Chengfei Pu, Xianyang Jiang, Guiting Han, Yuzhe Peng, Wensheng Wang, Wei Ding, et al. "Abstract 2838: Antigen-independent expansion enhances efficacy of CAR-T cells against solid tumor." Cancer Research 82, no. 12_Supplement (June 15, 2022): 2838. http://dx.doi.org/10.1158/1538-7445.am2022-2838.

Full text
Abstract:
Abstract One key hurdle for the CAR-T cell treatment of solid tumors is the limited accessibility of solid tumor antigens outside the tumor microenvironment, which prohibits the expansion of solid tumor-targeting CAR-T cells in patients. Here, we report the characterization of prostatic acid phosphatase (PAP) as a feasible CAR-T target for prostate cancer and a novel approach, named CoupledCAR, to expand solid tumor-targeting CAR-T cells lacking solid tumor antigens based on the observation of non-transduced T cells proliferating together with CD19 CAR-T cells during the treatment of acute lymphocyte leukemia. We demonstrated that CoupledCAR can significantly enhance the expansion and antitumor efficacy of PAP CAR-T cells both in vitro and in vivo. Furthermore, we showed that the expansion of solid tumor-targeting CAR-T cells does not depend on CAR/CD3ζ stimulation through direct antigen binding with CAR but enhances the memory status of CAR-T cells and causes little exhaustion. Since the CoupledCAR system does not rely on solid tumor antigens, we propose that it can be utilized in all CAR-T and T cell therapies for the treatment of solid tumors. Citation Format: Zhiyuan Cao, Chengfei Pu, Xianyang Jiang, Guiting Han, Yuzhe Peng, Wensheng Wang, Wei Ding, Xiaogang Shen, Dongqi chen, Beibei Jia, Xiaoqiang Xu, Zhipeng Huang, Xi Huang, Wenbi Liu, Ruihong Zhu, Lee Tian, Christopher Ballas, Victor.X Lu, Zhao Wu, Lei Xiao. Antigen-independent expansion enhances efficacy of CAR-T cells against solid tumor [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2838.
APA, Harvard, Vancouver, ISO, and other styles
29

Loskutoff, N. M., T. R. Bowsher, J. A. Chatfield, G. A. Stones, J. W. Ramey, L. Zhang, M. Putman, C. Boland, D. Wharton, and D. K. Gardner. "207OVARIAN STIMULATION, TRANSVAGINAL, ULTRASOUND-GUIDED OOCYTE RETRIEVAL, ICSI AND BLASTOCYST PRODUCTION IN SEQUENTIAL MEDIA IN THE WESTERN LOWLAND GORILLA (GORILLA GORILLA GORILLA)." Reproduction, Fertility and Development 16, no. 2 (2004): 225. http://dx.doi.org/10.1071/rdv16n1ab207.

Full text
Abstract:
Two young (ages: 15 and 16 yr;; studbook # 947 and # 939, respectively) parous female gorillas were initially primed with daily oral monophasic estrogen/progesterone treatment (Ovcon 35: Bristol-Myers Squibb Co., Princeton, NJ, USA) for 3 mo to synchronize their menstrual cycles. After withdrawing treatment, urine was tested daily for occult blood (Hemastix;; Baxter Healthcare Corp., Deerfield, IL, USA). On days 3–10 following the onset of menses (Day 1), ovarian activity was stimulated with 225 IU human FSH im (Repronex;; Ferring Pharmaceuticals, New South Wales, Australia). Then on Days 6–8 this treatment was combined with 25mg GnRH antagonist im (Antagon;; Organon, West Orange, NJ, USA) to prevent premature endogenous LH release. Final oocyte maturation was stimulated 36h after the last FSH/GnRH treatment with 10,000IU hCG im (Profasi;; Serono Lab., Hingham/Rockland, MA, USA) and oocyte retrieval was performed 36h post-hCG administration in sternal recumbency (knee-chest) using a 3–6mHz probe, 17-ga needles and 87mmHg (VMAR-5000 Regulated Vacuum Pump;; Cook Veterinary Products). Both gorillas displayed a thickened endometrium, and approximately 6 (# 947) to 10 (# 939) maturing follicles (10–15mm) were detected in each animal. In female # 947, one oocyte was collected but peritoneal fluid and pathology (hydrosalpinx) were also diagnosed and the right ovary showed no follicular development. A total of 3 oocytes were recovered in highly viscous follicular fluid containing massive amounts of cumulus cells. They were transported in a HEPES-buffered transport medium in a portable incubator (CryoLogic, Mulgrave, Victoria, Australia) at 37°C by airline immediately from Brownsville to Dallas, TX, USA, and within 6-h post-retrieval were fertilized by ICSI using cryopreserved sperm collected by rectal probe electrostimulation (age: est. 40yr ; studbook # 268). The fertilized oocytes were cultured in Gardner’s Sequential Medium at 37°C in 6% CO2 all three cleaved and developed to blastocysts by 115h post-ICSI. One high-quality expanding blastocyst was transported back to Brownsville, TX, and transferred transcervically into the oocyte donor (studbook # 939), and two fair-quality blastocysts were transported overnight to Omaha, NE, and transferred into a synchronized gorilla recipient (age: 29yr; studbook # 543/91). Weekly urine samples from the two embryo transfer recipients are being tested for pregnancy diagnosis using OvuQuick test strips (Quidel, San Diego, CA, USA). Acknowledgments: This research was supported in part by the Morris Animal Foundation (Ruth Morris Keesling Animal Health Study).
APA, Harvard, Vancouver, ISO, and other styles
30

Rampersad, S. N. "First Report of Anthracnose Caused by Colletotrichum gloeosporioides in Pumpkin in Trinidad." Plant Disease 94, no. 8 (August 2010): 1062. http://dx.doi.org/10.1094/pdis-94-8-1062a.

Full text
Abstract:
In Trinidad, pumpkin (Cucurbita pepo L. and C. moschata L.) is extensively grown for local and international export markets. In November 2008, symptoms of foliar chlorosis and necrosis were observed in 15 commercial pumpkin fields located in the main production areas of St. George East, Caroni, Victoria, and St. Patrick counties. Severely infected plants were unable to support fruit maturation, which resulted in yield loss. The pathogen was isolated from surface-sterilized tissues of symptomatic plants. Colonies on potato dextrose agar (PDA) were white to cream with gray spore masses in the center. Conidia were hyaline, cylindrical with rounded ends, aseptate, and measured 12.5 to 16.5 μm × 3.5 to 5.0 μm. PCR amplification was carried out with ITS4/5 universal primers (4) and species-specific primers, CgInt/ITS4 (1), using a positive control of Colletotrichum gloeosporioides (courtesy of D. Perez-Brito). Species-specific primers generated a single amplicon, ~450 bp long, which corresponded with the positive control. The ITS1 region (1) of pumpkin isolates (GenBank No. GU320190) was 100% identical to cognate sequences of C. gloeosporioides isolates (GenBank Nos. AY841136 and FJ624257). Phylogenetic analyses (MEGA 4 – Molecular Evolutionary Genetic Analysis Software version 4 for Windows) using the neighbor-joining (NJ) algorithm placed the pumpkin isolates in a well-supported cluster (>90% bootstrap value based on 1,000 replicates) with other C. gloeosporioides isolates. The tree was rooted with C. crassipes (GenBank No. AJ536230). The pathogen was similar to C. gloeosporioides (Penz.) Penz. & Sacc. (3). In pathogenicity tests, six plants (cv. Jamaican squash) for each of five isolates were spray inoculated to runoff with a conidial suspension (1.0 × 106 conidia/ml). Negative controls were sprayed with sterile distilled water. In repeated tests, plants were symptomatic of infection 7 days postinoculation. There were no symptoms on control plants. Koch's postulates were fulfilled with the reisolation of the pathogen from symptomatic leaf tissues. Anthracnose is a serious threat to cucurbit production; however, infection is not common in pumpkin and squash (2). To my knowledge, this is the first report of C. gloeosporioides causing widespread anthracnose infection in pumpkin in Trinidad. References: (1) A. E. Brown et al. Phytopathology 86:523, 1996. (2) G. Kelly. Acta Hortic. (ISHS) 731:479, 2007. (3) B. C. Sutton. Page 1 in: Colletotrichum: Biology, Pathology and Control. CAB International. Wallingford, UK, 1992. (4) T. J. White et al. Page 315 in: PCR Protocols: A Guide to Methods and Applications. Academic Press, San Diego, 1990.
APA, Harvard, Vancouver, ISO, and other styles
31

Madaras, Larry, Richard A. Diem, Kenneth G. Alfers, Elizabeth J. Wilcoxson, Victoria L. Enders, Robert Kern, Gerald H. Davis, et al. "Book Reviews." Teaching History: A Journal of Methods 11, no. 2 (May 4, 1986): 80–96. http://dx.doi.org/10.33043/th.11.2.80-96.

Full text
Abstract:
Ralph Lee Woodward, Jr., Central America: A Nation Divided. New York: Oxford University Press, 1985. Pp. 390. Cloth, $22.50; Paper $8.95. Second Edition. Review by Donald J. Mabry of Mississippi State University. Edward M. Anson. A Civilization Primer. San Diego: Harcourt Brace Jovanovich, 1985. Pp. 121. Spiral bound, $5.95. Review by Gordon R. Mork of Purdue University. Stephen J. Lee. Aspects of European History, 1494-1789. Second edition. London & New York: Methuen, 1984. Pp. viii, 312. Paper, $11.95. Review by Michael W. Howell of The School of the Ozarks. Roland N. Stromberg. European Intellectual History Since 1789. Englewood Cliffs, NJ: Prentice-Hall, Inc., 1986. Fourth edition. Pp. x, 340. Paper, $18.95. Review by Irby C. Nichols, Jr. of North Texas State University. R. W. Southern. Medieval Humanism and Other Studies. New York: Basil Blackwell, 1985. Pp. 261. Cloth, $24.95; Paper, $10.95. Review by Benjamin F. Taggie of Central Michigan University. H. T. Dickinson. British Radicalism and the French Revolution, 1789-1815. New York: Basil Blackwell, 1985. Pp. 88. Paper, $6.95; F. D. Dow. Radicalism in the English Revolution, 1640-1660. New York: Basil Blackwell, 1985. Pp. 90. Paper, $6.95. Review by Harry E. Wade of East Texas State University. H. R. Kedward. Occupied France: Collaboration and Resistance 1940-1944. New York: Basil Blackwell, 1985. Pp. 88. $6.95; M. E. Chamberlain. Decolonization: The Fall of the European Empire. New York: Basil Blackwell, 1985. Pp. 86. $6.95. Review by Steven Philip Kramer of the University of New Mexico. Harriet Ward. World Powers in the Twentieth Century. London: British Broadcasting Corporation and the Heinemann Educational Books, 1985. Second edition. Pp. xvii, 333. Paper, $12.00. Review by Gerald H. Davis of Georgia State University. Paul Preston, ed. Revolution and War in Spain, 1931-1939. London and New York: Methuen, 1984. Pp. xi, 299. Cloth, $29.95: Paper, $12.95. Review by Robert Kern of the University of New Mexico. Glenn Blackburn. The West and the World Since 1945. New York: St. Martin's Press, 1985. Pp. vi, 152. Paper, $9.95. Review by Victoria L. Enders of Northern Arizona University. M. K. Dziewanowski. A History of Soviet Russia. Englewood Cliffs, NJ: Prentice-Hall, Inc., 1985. Second edition. Pp. x, 406. Paper, $22.95. Review by Elizabeth J. Wilcoxson of Northern Essex Community College. Peter L. Steinberg. The Great "Red Menace": United States Prosecution of American Communists, 1947-1952. Westport, CT: Greenwood Press, 1984. Pp. xiv, 311. Cloth, $35.00. Review by Kenneth G. Alfers of Mountain View College. Winthrop D. Jordan, Leon F. Litwack, Richard Hoftstadter, William Miller, Daniel Aaron. The United States: Brief Edition. Englewood Cliffs, NJ: Prentice-Hall, Inc., 1985. Second Edition. Pp. xiv, 513. Paper, $19.95. Review by Richard A. Diem of The University of Texas at San Antonio. Edwin J. Perkins and Gary M. Walton. A Prosperous People: The Growth of the American Economy. Englewood Cliffs, NJ: Prentice-Hall, Inc., 1985. Pp. xiii, 240. Paper, $14.95. Review by Larry Madaras of Howard Community College.
APA, Harvard, Vancouver, ISO, and other styles
32

Miyano, Masaru, Rosalyn W. Sayaman, Parijat Senapati, Stefan Hinz, Victoria E. Seewaldt, Dustin Schones, and Mark A. LaBarge. "Abstract PR006: Integrating noise into a signal: Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility." Cancer Research 83, no. 2_Supplement_1 (January 15, 2023): PR006. http://dx.doi.org/10.1158/1538-7445.agca22-pr006.

Full text
Abstract:
Abstract Effects from aging in any single cell are unpredictable, whereas aging phenotypes at the organ and tissue levels tend to appear as stereotypical changes. The mammary epithelium, the origin of breast carcinomas, is a bilayer of two major phenotypically and functionally distinct cell lineages, the luminal epithelial and myoepithelial cells. We have shown that luminal epithelia exhibit substantial stereotypical changes with age, which merits attention as they are putative breast cancer cells of origin. Hallmark aging changes in mammary gland are loss of lineage specificity in luminal epithelia exemplified by acquiring expression of proteins normally reserved for myoepithelial cells, and progenitor cells that accumulate and attain a basal differentiation bias. We hypothesize that effects from aging that impinge upon maintenance of lineage specificity increases susceptibility to cancer initiation. Indeed, histologically normal breast tissue from young women, who were known to be highly susceptible to breast cancer because they harbor a germline mutation in BRCA1, BRCA2, or PALB2 genes, exhibited hallmarks of accelerated aging. These included increased proportions of luminal epithelial cells with acquired myoepithelial proteins, acceleration of a breast specific biological clock by 10 to 40 years compared to chronological age, and a basal differentiation bias or failure of differentiation of cKit+ progenitors. To gain insight into the underlying molecular changes we interrogated transcriptomes, proteomes, and methylomes of mammary epithelia at lineage resolution. Strikingly, age-dependent differential gene expression and DNA methylation occurred almost exclusively in luminal epithelia, whereas changes due to increased variance of gene and protein expression occurs in both luminal and myoepithelial lineages. Most gene changes that were previously associated with early breast cancer are detectable as age-driven changes in normal luminal epithelia. The genes with age-dependent differential and variant changes in expression distinguish normal tissue from breast cancers and are predictive of PAM50 breast cancer subtypes. Heterochronus, multilineage, co-cultures demonstrated that the age-dependent phenotype of luminal cells is at least partly dependent on the microenvironment created on the apical surfaces of neighboring myoepithelial cells. We show that increased variance is a substantial outcome of aging and is likely central to understanding increased susceptibility to breast cancer with age. We speculate that the luminal epithelium is a site of integration of the variant responses to aging in their surrounding tissue, and that their emergent phenotype of aging both endows cells with the ability to become a cancer cell of origin and embodies a biosensor that presages one’s cancer susceptibility. Citation Format: Masaru Miyano, Rosalyn W. Sayaman, Parijat Senapati, Stefan Hinz, Victoria E. Seewaldt, Dustin Schones, Mark A. LaBarge. Integrating noise into a signal: Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility [abstract]. In: Proceedings of the AACR Special Conference: Aging and Cancer; 2022 Nov 17-20; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2022;83(2 Suppl_1):Abstract nr PR006.
APA, Harvard, Vancouver, ISO, and other styles
33

Bonomo, Diego Zancanella, Robson Bonomo, Fábio Luiz Partelli, and Joabe Martins de Souza. "GENÓTIPOS DE CAFÉ CONILON SOB AJUSTE DE DIFERENTES COEFICIENTES DE CULTURA AJUSTADOS." IRRIGA 22, no. 2 (July 20, 2017): 236–48. http://dx.doi.org/10.15809/irriga.2017v22n1p236-248.

Full text
Abstract:
GENÓTIPOS DE CAFÉ CONILON SOB AJUSTE DE DIFERENTES COEFICIENTES DE CULTURA AJUSTADOS DIEGO ZANCANELLA BONOMO1; ROBSON BONOMO2; FÁBIO LUIZ PARTELLI2 E JOABE MARTINS DE SOUZA3 1Engenheiro Agrônomo, Mestre em Agricultura Tropical, Departamento de Ciências Agrárias e Biológicas CEUNES/UFES, São Mateus, ES. E-mail: diegozancanella@yahoo.com.br.2Professor Doutor do Departamento de Ciências Agrárias e Biológicas, Universidade Federal do Espírito Santo, CEUNES/UFES, São Mateus, ES. E-mail: robson.bonomo@ufes.br; fabio.partelli@ufes.br. 3Pós-Doutorando no Centro Universitário Norte do Espírito Santo da Universidade Federal do Espírito Santo, e-mail: joabenv@gmail.com. 1 RESUMO Objetivou-se com esse trabalho avaliar diferentes genótipos de café Conilon sob ajustes de diferentes coeficientes de cultura ajustado (Kcajust). O delineamento experimental foi o inteiramente casualizado em parcela subdividida com quatro repetições, sendo seis parcelas de lâminas de irrigação, aplicadas com a substituição do Kc por coeficientes aqui denominados de Kcajust, (0,25; 0,50; 0,75; 1,00; 1,25; 1,50 % da ETloc). As subparcelas foram cinco diferentes genótipos, 02 e 03 da variedade ‘Vitória Incaper 8142’, genótipo 153 da variedade ‘Emcapa 8131’, e o genótipo "bamburral" e 18. Avaliou-se, a produtividade, o rendimento e a classificação dos grãos de café em peneira, em cada genótipo e safra. O genótipo "bamburral" e 153 obtiveram uma produtividade de 124 sc ha-1 (Kcajust= 1,07) e 114 sc ha-1 respectivamente. Os genótipos 02 e 03 apresentaram máxima produtividade com Kcajust de 0,91 (105 sc ha-1) e 0,96 (96,56 sc ha-1), e melhor rendimento para o Kcajust igual à 1,01 (genótipo 02), e pior para Kcajust igual à 1,15 (genótipo 03). Os genótipos e as safras apresentaram-se diferentes quando ao Kcajust para a produtividade e rendimento, e uma variação no percentual de grãos retidos em peneira para o genótipo 03. O Kcajust igual a 1,00 proporcionou os melhores parâmetros. Palavras-chave: Coffea canephora, produtividade, peneira, gotejamento, manejo irrigação. BONOMO, D. Z.; BONOMO, R.; PARTELLI, F. L.; SOUZA, J. M.PERFORMANCE OF CONILON COFFEE GENOTYPES UNDER DIFFERENT ADJUSTED CROP COEFFICIENTS 2 ABSTRACT The objective of this work was to evaluate Conilon coffee genotypes submitted to different adjusted crop coefficients (Kcajust). The experimental delineation was a completely randomized in split plot with six plots as irrigation depths, which has replaced Kc by a coefficient here denominated Kcajust (0.25, 0.50, 0.75, 1.00, 1 25, 1.50) corresponding to evapotranspiration percentages for localized irrigation, five subplots (genotypes) and four replications. Productivity, yield and classification of coffee beans in sieve in each genotype and harvest were assessed. The genotype "bamburral" and 153 obtained yield of 124 sacks ha-1 (Kcajust = 1.07) and 114 sacks ha-1 respectively. Genotypes 02 and 03 of variety 'Victoria Incaper 8142' presented maximum productivity with Kcajust 0.91 (105 sacks ha-1) and 0.96 (96.56 sacks ha-1). Genotype 02 presented the best yield (Kcajust = 1.01; 4.32 sacks harvested by sacks benefitted), and genotype 03 was the worst (Kcajust = 1.15, 4.75 sacks harvested by benefitted sacks). Genotypes and harvests had behavior differentiated when the Kcajust for productivity and yield while also providing a variation in the percentage of grain retained in sieve for genotype 03. The Kcajust equal to 1.00 showed the best parameters. Keywords: Coffea canephora, productivity, sieve, drip, irrigation management
APA, Harvard, Vancouver, ISO, and other styles
34

Capelusnik, D., D. Benavent, D. Van der Heijde, R. Landewé, D. Poddubnyy, A. Van Tubergen, L. Falzon, V. Navarro-Compán, and S. Ramiro. "POS0302 TREATING SPONDYLOARTHRITIS EARLY: DOES IT MATTER? RESULTS FROM A SYSTEMATIC LITERATURE REVIEW." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 399.2–400. http://dx.doi.org/10.1136/annrheumdis-2022-eular.735.

Full text
Abstract:
BackgroundSo far, no consensus has been reached on a definition of early SpA. The ASAS-SPEAR (SPondyloarthritis EARly definition) project aims to develop a consensual definition. Therefore, it is important to know whether treatment earlier in the disease course compared to treatment of established disease leads to better outcomes in axSpA.ObjectivesTo summarize the evidence on the relationship between symptom duration or the presence of radiographic damage and clinical response in patients with axSpA treated with NSAIDs, bDMARDs or tsDMARDs.MethodsA SLR was conducted using Medline, EMBASE and the Cochrane Library (April 28, 2021), supplemented by hand-searches in the FDA website. Randomized controlled trials (RCTs) and cohort studies in patients with axSpA addressing the impact of symptom duration or disease duration and presence of radiographic damage on treatment response (to NSAIDs, b/tsDMARDs) were included. Based on a cut-off of symptom/disease duration or the absence/presence of radiographic damage, groups of ‘early’ and ‘established’ disease were compared. Treatment outcomes were measures of disease activity, function or quality of life.Two reviewers independently identified eligible studies and extracted the data, including the risk of bias (RoB) assessment. For categorical outcomes we calculated relative risk (RR), relative risk ratio (RRR) and number needed to treat (NNT), and differences in differences (DID) for continuous outcomes.ResultsFrom the 8769 articles retrieved, 23 were included and 3 added by hand-search, most of them with low RoB. Nineteen studies (9 RCTs) compared groups based on symptom (n=6)/disease duration (n=13) and 7 studies (4 RCTs) based comparisons on absence/presence of radiographic damage in posthoc analyses.When early axSpA was defined by symptom duration in RCTs (n=4), in patients with nr-axSpA, early treatment was associated with higher RR and RRR and lower NNT for ASAS40 in two studies (Table 1); a third study showed that patients achieving ASDAS-ID and ASAS-PR had shorter symptom duration than those not achieving this. Lastly, in one study including patients with axSpA patients, no difference in treatment response was observed based on symptom duration. In most of the cohort studies using a definition based on symptom/disease duration (n=10), no association was found between symptom/disease duration and treatment response (n=8). Only in one cohort study, disease duration was a significant predictor of quality of life, and in another cohort study, it was a predictor of functional improvement.Table 1.Assessment of treatment response in RCTs based on symptom durationStudyPopulationEarly vs established (years)RR (early vs established)RRR (95%IC)NNTs (early vs established)ASAS20Landewé 2014axSpA<5 vs ≥51.5 vs 1.50.96 (0.53-1.73)5.5 vs 4.8ASAS40Sieper 2012nr-axSpA<5 vs ≥58.2 vs 1.65.24 (1.12-24.41)2.4 vs 9.1Kay 2019nr-axSpA<5 vs ≥55.0 vs 3.31.52 (0.60-3.87)2.1 vs 3.93.6 vs 3.51.01 (0.46-2.20)2.1 vs 2.9ASDAS-MIKay 2019nr-axSpA<5 vs ≥55.1 vs 6.50.78 (0.19-3.16)2.7 vs 4.97.1 vs 6.41.11 (0.34-3.66)2.1 vs 3.0StudyPopulationSymptom durationp valueRespondersNon respondersASDAS-IDSieper 2019nr-axSpA6.1±6.28.3±8.1<0.001ASAS-PRSieper 2019nr-axSpA5.3±5.78.0±7.8<0.001Cell coloursIn favor of early diseaseIn favor of establish diseaseNon significantWhen early axSpA was defined based on disease duration or the presence of radiographic damage, there was no significant difference in response to treatment between early and established axSpA.ConclusionStudies addressing treatment response based on symptom duration or radiographic damage in axSpA are scarce.When defining early axSpA based on symptom duration, in nr-axSpA, treatment with bDMARDs may lead to better outcomes compared to established axSpA whereas in axSpA there is no difference in response to treatment between early and established disease.When early axSpA is defined based on disease duration or radiographic damage, no differences in response to treatment are found between early and established disease.AcknowledgementsThe Assessment of Spondyloarthritis international Society (ASAS) supported Diego Benavent financially for this work.Disclosure of InterestsDafne Capelusnik Speakers bureau: Bristol Myers Squibb, Pfizer, Grant/research support from: Pfizer, Diego Benavent Speakers bureau: Janssen, Roche, Grant/research support from: Novartis, Désirée van der Heijde Consultant of: AbbVie, Bayer, BMS, Cyxone, Eisai, Galapagos, Gilead, Glaxo-Smith-Kline, Janssen, Lilly, Novartis, Pfizer, UCB PharmaDirector of Imaging Rheumatology bv., Robert Landewé Consultant of: AbbVie, BMS, Galapagos, Gilead, GSK, Janssen, Lilly, Novartis, Pfizer, UCB, Denis Poddubnyy Speakers bureau: AbbVie, Bristol-Myers Squibb, Eli Lilly, MSD, Novartis, Pfizer, and UCB, Consultant of: AbbVie, Biocad, Eli Lilly, Gilead, GlaxoSmithKline, Janssen, MSD, Novartis, Pfizer, Samsung Bioepis, and UCB, Grant/research support from: AbbVie, Eli Lilly, MSD, Novartis, and Pfizer, Astrid van Tubergen Consultant of: Novartis, Galapagos, Grant/research support from: Pfizer, UCB, Novartis, Louise Falzon: None declared, Victoria Navarro-Compán Speakers bureau: AbbVie, Eli Lilly, Janssen, MSD, Novartis, Pfizer, UCB Pharma, Consultant of: AbbVie, Eli Lilly, MSD, Novartis, Pfizer, UCB Pharma, Grant/research support from: AbbVie, Novartis, Sofia Ramiro Speakers bureau: Eli Lilly, MSD, Novartis, UCB, Consultant of: AbbVie, Eli Lilly, MSD, Novartis, Pfizer, UCB, Sanofi, Grant/research support from: AbbVie, Galapagos, Novartis, Pfizer, UCB
APA, Harvard, Vancouver, ISO, and other styles
35

Dolezal, W., K. Tiwari, R. Kemerait, J. Kichler, P. Sapp, and J. Pataky. "An Unusual Occurrence of Southern Rust, Caused by Rpp9-virulent Puccinia polysora, on Corn in Southwestern Georgia." Plant Disease 93, no. 6 (June 2009): 676. http://dx.doi.org/10.1094/pdis-93-6-0676a.

Full text
Abstract:
Southern rust, caused by Puccinia polysora Underw., occurs frequently on corn (Zea mays) grown in subtropical or tropical regions. When conditions are favorable, southern rust also occurs in temperate climates of the central and southern United States although the fungus does not survive on corn crop residue and must be introduced to temperate regions each growing season. Several single, dominant, resistance genes, designated as Rpp genes, convey hypersensitive, chlorotic fleck reactions when challenged with avirulent isolates of P. polysora (1). Rpp resistance prevents or limits the formation of uredinia. The Rpp9 gene has been used successfully in North America in the past 20 years to control southern rust even though the gene has been ineffective in other parts of the world (e.g., Africa and Hawaii) because of the prevalence of virulent races. During the past 3 years, Rpp9 virulence has occurred in the western hemisphere (e.g., Brazil, Mexico, Nebraska, and Texas), but prior to 2008, uredinia were not observed east of the Mississippi River on corn with the Rpp9 gene. A few uredinia were observed on corn with the Rpp9 gene in eastern Nebraska in 2006 and near Victoria, TX in 2007 (W. Dolezal, personal observation). In July of 2008, a virulent isolate of P. polysora was confirmed from Grady County, GA on corn lines with the Rpp9 gene including the original source of this resistance gene, Boesman yellow flint, which is PI 186208 (3). In August of 2008, isolates of P. polysora were collected from severely infected corn hybrids with Rpp9 grown in Macon County, GA. Rust samples from hybrids without Rpp genes also were collected in Burke County, GA where Rpp-resistant corn was asymptomatic. In greenhouse trials, corn lines with and without the Rpp9 gene were inoculated with urediniospores from collections from Burke and Macon counties and Illinois. Rust infection types (1) were scored 18 to 25 days after inoculation. The Macon County isolate produced type 1 and 2 infections (small uredinia surrounded by necrotic or chlorotic tissue) on Oh43Rpp9 and W64aRpp9 and type 4 infections (large, sporulating uredinia) on two versions of a commercial hybrid with and without the Rpp9 gene and on Va59 (which carries an Rpp gene different from Rpp9). The Burke County isolate and an isolate from Illinois collected in 2001 produced type 0 infections (chlorotic flecks) on all of these lines except the non-Rpp version of the commercial hybrid which had a type 4 reaction. To our knowledge, Rpp9-virulent isolates of P. polysora have not been reported from the continental United States for nearly 50 years. In the late 1950s and early 1960s, A. L. Robert (2) collected isolates of P. polysora from throughout the world and observed multiple races on a set of host differentials that is no longer available. A. L. Robert's collection included an isolate from Georgia that was virulent on PI 186208. Commercial hybrids containing the Rpp9 gene may continue to be resistant throughout most of North America if previously common Rpp9-avirulent isolates of P. polysora are prevalent, but those hybrids should be carefully monitored for infection by newly introduced Rpp9-virulent isolates. References: (1) A. L. Hooker. Page 207 in: The Cereal Rusts. Vol. II. Academic Press, San Diego, 1985. (2) A. L. Robert. Phytopathology 52:1010, 1962. (3) A. J. Ullstrup. Phytopathology 55:425, 1965.
APA, Harvard, Vancouver, ISO, and other styles
36

You, M. P., V. Lanoiselet, C. P. Wang, and M. J. Barbetti. "First Report of Alternaria Leaf Spot Caused by Alternaria tenuissima on Blueberry (Vaccinium corymbosum) in Western Australia." Plant Disease 98, no. 3 (March 2014): 423. http://dx.doi.org/10.1094/pdis-07-13-0737-pdn.

Full text
Abstract:
Blueberry (Vaccinium corymbosum) plants in a commercial plantation at Yanchep, Western Australia, in April and May 2013, showed a widespread leaf spotting condition. Leaf lesions were circular to irregular, light brown to gray, 1 to 5 mm in diameter, with distinct dark brownish red borders. A fungus was consistently recovered by plating surface-sterilized (1% NaOCl) sections of symptomatic leaf tissue onto water agar and sub-culturing onto potato dextrose agar (PDA). For conidial production, the fungus was grown on PDA under a 12-h/12-h dark/light photoperiod at 25°C. Fungal colonies had a dark olive color on both sides, with loose, cottony mycelium on the surface of cultures. Isolates showed morphological similarities to Alternaria tenuissima as described in other reports (1,3). Simple conidiophores ranged from 16.3 to 96.6 μm (mean 37.5 μm) and produced numerous conidia in long chains. Conidia ranged from 7.0 to 23.9 μm (mean 13.9 μm) in length and 3.9 to 7.5 μm (mean 5.7 μm) in width, contained two to five transverse septa, but only an occasional longitudinal septum was observed. Using a representative isolate, a PCR-based assay with the ITS1 and ITS4 primers was used to amplify from the 3′ end of 16S rRNA, across ITS1, 5.8S rRNA, and ITS2 to the 5′ end of the 26S rRNA (4). The DNA products were sequenced and BLAST analyses were used to compare sequences with those in GenBank (2). The sequence had ≥99% nucleotide identity with the corresponding sequence in GenBank (Accession No. KC568287) for A. tenuissima. The relevant information for a representative isolate has been lodged in GenBank (KF408355). A conidial suspension of 2.5 × 105 conidia ml–1 from a single-spore culture was spot inoculated onto 20 leaves, ranging from recently emerged to oldest, of 6-month-old V. corymbosum Nellie Kelly plants maintained at 18/13°C 12-h/12-h day/night and >90% relative humidity for 72 h post inoculation. Symptoms were evident by 18 days post inoculation and by 24 days consisted of pale brown lesions that were mostly 2.1 to 2.5 μm in diameter and with distinct dark brownish red borders. A. tenuissima, showing morphological characteristics identical to those described above, was re-isolated from lesions to fulfill Koch's postulates. No lesions occurred on an equivalent number of leaves of control plants inoculated with only deionized water. A culture of this representative isolate has been lodged in the Western Australian Culture Collection Herbarium maintained at the Department of Agriculture and Food Western Australia (Accession No. WAC13639). A. tenuissima has been reported across Australia on a range of other hosts. However, on V. corymbosum, the pathogen has only previously been recorded in Tasmania (2009). It may also have been the cause of a leaf spotting condition on V. corymbosum recorded in Victoria (1976) and New South Wales (1984), but mistakenly listed with A. alternata as the cause. To the best of our knowledge, this is the first record of A. tenuissima on V. corymbosum in Western Australia. With 10 to 30% of leaves showing disease symptoms widely spread on many V. corymbosum plants in the commercial plantation, this pathogen could potentially adversely affect the future production of blueberries in Western Australia. References: (1) F. L. Caruso and R. C. Ramsdell, eds. Compendium of Blueberry and Cranberry Diseases. American Phytopathological Society, St. Paul, MN, 1995. (2) J. C. Kang et al. Mycol. Res. 106:1151, 2002. (3) E. G. Simmons. Mycotaxon 70:325, 1999. (4) T. J. White et al. Pages 315-322 in: PCR Protocols: A Guide to Methods and Applications. Academic Press, San Diego, 1990.
APA, Harvard, Vancouver, ISO, and other styles
37

Núñez, Clara Eugenia. "José Antonio Ayala, María del Carmen Bel Adell, Francisco Calvo García-Tornell, Enrique Egea Ibáñez, José Egea Ibáñez, Pedro María Egea Bruno, Guy Lemeunier, Francisco López Bermúdez, María Teresa Pérez Picazo, y Diego Victoria Moreno: Estudios sobre Historia Económica Contemporánea en la región de Murcia, editado por el Consejo de Cámaras de Comercio, Industria y Navegación de la región de Murcia, 1983." Revista de Historia Económica / Journal of Iberian and Latin American Economic History 3, no. 2 (September 1985): 361–63. http://dx.doi.org/10.1017/s0212610900013872.

Full text
APA, Harvard, Vancouver, ISO, and other styles
38

Scott, I. "Atwell BJ, Kriedemann PE, Turnbull CGN. 1999. Plants in action: adaptation in nature, performance in cultivation. 664 pp. South Yarra, Victoria: Macmillan Education Australia. AU $74.95 (hardback). Callow JA, ed. 1998.Advances in botanical research. Volume 28 . 294 pp. San Diego, London: Academic Press. $99.95 (hardback). Nobel PS. 1999.Physicochemical and environmental plant physiology. 2nd edn. 474 pp. London: Academic Press. £39.95 (softback)." Annals of Botany 84, no. 5 (November 1999): 685–87. http://dx.doi.org/10.1006/anbo.1999.0969.

Full text
APA, Harvard, Vancouver, ISO, and other styles
39

Franco Gomez, K. N., C. Plasencia, M. Novella-Navarro, D. Benavent, P. Bogas, R. Nieto, I. Monjo, et al. "AB0646 IS IT FEASIBLE TO ACHIEVE RECOMMENDED THERAPEUTICAL TARGET IN PATIENTS WITH AXIAL SPONDYLARTHRITIS IN CLINICAL PRACTICE? DATA FROM THE SpA-Paz COHORT." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 1617.1–1618. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4617.

Full text
Abstract:
Background:Current ASAS/EULAR recommendations for the management of patients with axial spondylarthritis (axSpA) establish that the therapeutic goal to achieve in clinical practice is remission, defined as the absence of both clinical and laboratory disease activity evaluated by BASDAI&CRP or preferably ASDAS and if this is not possible, low disease activity may be an alternative. Recently, ASDAS nomenclature has been modified, calling now low disease activity to what was previously called moderate activity. To this day we do not know if this target is feasible in clinical practice.Objectives:To analyze the frequency of patients with axSpA achieving maintained remission (R) or low disease activity (LDA) after receiving biological therapy. Secondary objectives included: i) to assess if the activity index used influences the frequency of maintained R/LDA, ii) analyze the prognostic factors for achieving maintained R/LDA.Methods:An observational, longitudinal study of a prospective cohort (SpA-Paz) including all patients with axSpA who initiated their first biological treatment between the years 2003-2017. Demographic, clinical and analytical data were collected at the beginning of treatment and clinical disease activity measured by BASDAI&CRP and ASDAS every 6 months for 2 years. Maintained R was defined as (BASDAI<2 & normal CRP and/or ASDAS <1.3) and maintained LDA (BASDAI <4 & normal CRP and/or ASDAS <2.1) on at least 3 consecutive visits. Statistical analysis: i) measures of central tendency and dispersion for quantitative variables and frequencies for qualitative variables; ii) univariate and multivariate analysis of binomial logistic regression model and calculation of OR and 95% CI.Results:Out of 186 patients with axSpA who started treatment during the study period, 63% were men with a mean age of 54 ± 14.1 years. 75.3% of the patients had radiographic axSpA and 74.7% were HLA-B27 positive. Other baseline characteristics (not shown due to space restrictions). Overall, 80% of the patients achieved ASDAS R/LDA (R36%/LDA44%) in at least one of the visits after 2 years of follow-up, but only 40% (R27%/LDA13%) fulfilled the maintained ASDAS R/LDA state. On the other hand, 73% of patients were classified as BASDAI&CRP R/LDA (R31%/LDA42%) in at least one of the visits, but only 31% (R21%/LDA10%) obtained the maintained BASDAI&CRP R/LDA state. In the multivariate analysis, we observed an independent statistically significant association with male sex (OR=3.19; 95% CI=1.46-6.99), younger age at the beginning of the biological treatment (OR=0.97; 95% CI=0.95-0.99) and the use of methotrexate (OR=3.07; 95% CI=1.39-6.78) in patients who achieved maintained BASDAI&CRP R/LDA and with male sex (OR=4.01; 95% CI=1.83-8.77), younger age at the beginning of the biological therapy (OR=0.96; 95% CI=0.94-0.99) and HLA B27 presence (OR=4.30; 95% CI=1.68-11.01) in patients who achieved maintained ASDAS R/LDA.Conclusion:Although the majority of patients with axSpA who initiate biological therapy achieve the recommended therapeutic goal in the first two years of treatment, the percentage of patients who manage to maintain the R/LDA status is limited. In our study, maintained R was more frequent than maintained LDA, being somewhat higher when measured by ASDAS. This fact may suggest that patients who achieve maintained R have a greater inhibition of their inflammatory activity and, therefore, it remains in time. Male sex and younger age at the beginning of the biological therapy were the main baseline predictors for achieving maintained R/LDA.Graphics:Disclosure of Interests:Karen Nathalie Franco Gomez: None declared, Chamaida Plasencia: None declared, Marta Novella-Navarro: None declared, Diego Benavent: None declared, Patricia Bogas: None declared, Romina Nieto: None declared, Irene Monjo: None declared, Laura Nuño: None declared, Alejandro Villalva: None declared, Diana Peiteado Grant/research support from: AbbVie, Lilly, MSD, and Roche, Speakers bureau: AbbVie, Roche, and MSD, Alejandro Balsa Grant/research support from: BMS, Roche, Consultant of: AbbVie, Gilead, Lilly, Pfizer, UCB, Sanofi, Sandoz, Speakers bureau: AbbVie, Lilly, Sanofi, Novartis, Pfizer, UCB, Roche, Nordic, Sandoz, Victoria Navarro-Compán Consultant of: Abbvie, Lilly, Novartis, Pfizer, UCB, Speakers bureau: AbbVie, MSD, Lilly, Novartis, Pfizer, UCB
APA, Harvard, Vancouver, ISO, and other styles
40

Martínez-Feito, A., B. Hernández-Breijo, M. Novella-Navarro, V. Navarro-Compán, C. Diego, I. Monjo, L. Nuño, et al. "POS0617 ANTI INFLIXIMAB ANTIBODIES DETECTED BY A DRUG TOLERANT ASSAY ARE FREQUENT BUT, IN MANY CASES, WITHOUT RELEVANT CLINICAL SIGNIFICANCE." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 546.1–546. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1791.

Full text
Abstract:
Background:Infliximab (Ifx) has proven effective in treating rheumatoid arthritis (RA) and spondyloarthropathies (SpA), although around 40% of cases fails, mainly due to immunogenicity. Formation of immunocomplexes between antibodies to Ifx (ATI) and Ifx can increase drug clearance, leading to treatment failure. Standard ELISA assays which are drug -sensitive are frequently used, being able to detect only free ATI. Interest in drug-tolerant assays to measure total ATI (free and complexed) is increasing.Objectives:To compare the development of ATI using both drug-tolerant and drug-sensitive assays at early stages of Ifx therapy. To analyse the relationship of ATI detected by both assays with the drop-out of treatment.Methods:This is a prospective observational study including 45 patients with RA and 61 with axial-SpA treated with standard doses of Ifx (3mg/kg and 5mg/kg, respectively) enrolled at Biological Therapy Unit of Hospital La Paz. Serum samples were obtained at 2, 6, 12 and 22 weeks (W) after Ifx initiation. The data about discontinuation for inefficacy was obtained from the database. ATI presence was evaluated by a drug-sensitive in-house two-site (bridging) ELISA (bELISA) and a drug-tolerant commercial ELISA assay (Immundiagnostik®,IDK). All comparisons were performed throughout non-parametrical test. In SpA group, due to the low number of ATI+ patients at W12 by bELISA the statistical analysis to compare both assays were not performed.Results:ATI detection by both assays at early stages (≤22 W) of treatment is shown in Table 1a. ATI were always detected earlier by IDK than bELISA and also in RA than in SpA patients probably reflecting the effect of lower Ifx doses. Three out of 106 (3%) vs 0 (0%) patients had ATI at W 2 and 62 (58%) vs 20 (18%) patients at W22, by IDK and bELISA, respectively.Table 1.Patient characteristics of all included patientsW2W6W12W22ARSpAARSpAARSpAARSpAa) ATI+ patients (n, %) at early stagesbELISA003(7%)010(22%)1(2%)13(29%)7(12%)IDK1(2%)2(3%)7(16%)2(3%)16(36%)16(26%)28(62%)34(56%)b) Patients who discontinued (n, %) Ifx therapy considering ATI status at early stagesbELISA+9(90%)*1(100%)*12(92%)4(57%)bELISA-23(66%) 22(37%)20(63%)19(35%)IDK+15(94%)*7(44%)24(86%)13(38%)IDK-17(59%)11(24%)13(77%)10(27%)*p<0.05 comparing between ATI+ vs ATI- in each assay.Once ATIs appeared, regardless both methods, they persisted throughout the follow-up, indicating that immunogenicity was not transient.At W22, only 13/28 (46%) and 7/34 (21%) patients with ATI detected by IDK were also positive by bELISA in RA and SpA, respectively.ATI levels by IDK were higher in ATI+ by bELISA than in ATI- patients at early stages: ATI levels by IDK at W12: 91[74-348] ng/ml ATI+ vs 21.7[15-59.5] ng/ml ATI- (p<0.01) and at W22: 132 [89-372] ng/ml ATI+ vs 23[13-66] ng/ml ATI- (p<0.001). However, only in 4% (2/45) patients with RA and in 13% (8/61) patients with SpA the detection by IDK was earlier than by bELISA at W12.Free IFX in serum was not detected in bELISA ATI+ patients. In IDK ATI+ patients low circulating Ifx levels were present as compare to ATI- since W6 to the end of follow-up (p<0.01).More ATI+ patients dropped out Ifx at W12 and W22 regardless de assay (Table 1.b), being statistically significant for both assays in patients with RA and only for bELISA in patients with SpA.Conclusion:ATI measured by a drug-tolerant assay are always detected earlier than ATI detected by bELISA, indicating that immunogenicity, at least with Ifx, is usually an early event. High levels of ATI by IDK are associated with an earlier detection by bELISA in case of RA patients. ATI detected only by drug tolerant assays are associated with low levels of circulating Ifx but not with a complete drug neutralization and may do not have clinical relevance compared to ATI detected by bELISA. Many patients have low levels of ATI which can only be detected by drug tolerant assays after long-term of follow-up.The reasons why ATI levels rise rapidly in some patients while in others remain low are currently unknown but may be relevant if the clinical effect of immunogenicity is to be minimized.Acknowledgements:We are grateful to all the rheumatologists and nurses of the Daycare Department for Biologics and to the laboratory technicians of the Immunological UnitDisclosure of Interests:ANA MARTÍNEZ-FEITO: None declared, Borja Hernández-Breijo: None declared, Marta Novella-Navarro: None declared, Victoria Navarro-Compán Grant/research support from: AbbVie, Janssen, Lilly, Novartis, Pfizer, and UCB, Cristina Diego: None declared, Irene Monjo: None declared, Laura Nuño: None declared, Alejandro Villalva: None declared, Diana Peiteado: None declared, DORA PASCUAL-SALCEDO: None declared, Pilar Nozal: None declared, Alejandro Balsa Grant/research support from: Abbvie, Pfizer, Novartis, Roche.Amgen, Sandoz, Lilly, UCB. Personal fees and non- financial support from BMS. Grants, personal fees and non- financial support from Nordic., Chamaida Plasencia Grant/research support from: AbbVie, Lilly, Novartis, Pfizer,Sanofi, Biogen and UCB.
APA, Harvard, Vancouver, ISO, and other styles
41

Izeta, Andrés D. "Editorial." Revista del Museo de Antropología 12, no. 1 (April 30, 2019): 5. http://dx.doi.org/10.31048/1852.4826.v12.n1.24185.

Full text
Abstract:
<p>Hace exactamente cuatro meses se publicaba el último número correspondiente al año 2018. Esto es significativo ya que con ello podemos observar que hemos acortado el plazo de publicación en dos meses por número permitiéndonos alcanzar el objetivo planteado durante el año 2018 que era poder cambiar la periodicidad de la revista a tres número al año. Esto implica un mayor volumen de trabajos que permitan diseminar investigaciones originales en el campo de la antropología, expresada en todas sus ramas y vertientes. Por otro lado también muestra un compromiso ante la tarea editorial con el fin de poder brindar un servicio de calidad a los autores y la posibilidad de un acceso abierto a las publicaciones desde el momento en que son publicadas. Esto implica el esfuerzo constante de instituciones y personas que en conjunto permiten el crecimiento de esta revista.</p><p>En este número presentamos diez artículos originales, una traducción y un comentario de libro que se suman a una cada vez más extensa colección de trabajos antropológicos. Ocho corresponden a la Sección Arqueología; uno a la Sección Museología; y tres a Antropología Social.</p><p>En el primer trabajo de la Sección Arqueología los autores Mónica Alejandra Berón y Manuel Pedro Carrera Aizpitarte discuten la posibilidad de considerar al chert silíceo como un indicador de movilidad e interacciones a larga distancia para la región occidental pampeana. Jimena Doval y Alicia Haydé Tapia presentan los resultados del análisis efectuado a fragmentos de cuero recuperados en contextos arqueológicos de fines del siglo XIX en la actual provincia de La Pampa. María Victoria Fernández, Pablo Rodrigo Leal, Claudia Della Negra, Catherine Klesner, Brandi Lee MacDonald, Michael Glascock y Ramiro Barberena dan a conocer los muestreos realizados en el valle del río Varvarco, su contexto geológico y geomorfológico, la presencia de obsidiana, la caracterización del tipo de yacimiento, la forma de presentación, distribución y abundancia de la misma con el fin de caracterizar esta nueva fuente de importancia arqueológica. Paula Elisabet Galligani, Gustavo Barrientos y María Rosario Feuillet Terzaghi tienen como objetivo de su trabajo estimar, a partir de la medición de la concentración de fósforo extraíble (Pe) y del modelado espacial con técnicas de interpolación, la extensión probable del área de entierro detectada en el sitio Río Salado-Coronda II (RSCII), localizado en la ciudad de Santo Tomé, en el centro-este de la provincia de Santa Fe. María Gabriela Musaubach y María del Pilar Babot analizan el estado del arte del conocimiento sobre los usos pasados y presentes de las gramíneas en el desierto de altura puneño a través del estudio de microfósiles. Por otro lado, Anahí Re y Juan Bautista Belardi abordan el análisis de las representaciones rupestres de los sitios Bloque 1 del Campo de Bloques 1 y Alero con Manos del Río Chalía, relevados en los sectores bajos asociados a la cuenca de los lagos Tar y San Martín (sudoeste de la provincia de Santa Cruz). El autor Federico Restifo presenta el análisis de atributos cualitativos y cuantitativos de un conjunto de artefactos Saladillo recuperado en el sector Norte del valle Calchaquí, el cual se encuentra disponible en el Museo Arqueológico de Cachi, provincia de Salta (Argentina). Cerrando la sección, Miguel Ángel Zubimendi, Alicia Castro, Pablo Ambrústolo y Carolina Contreras presentan la descripción de un diente fósil de tiburón, así como los estudios que sustentan la identificación de las modificaciones antrópicas que confirman su caracterización como objeto adorno-colgante para contextos arqueológicos de la costa norte de la provincia de Santa Cruz.</p><p>En la Sección de Museología, Luis Adrián Galindo analiza el Museo de Quai Branly-Jean Chirac a través de un “discurso normativo de la museología eurocentrista”…” [que] ... ”logra imponerse a partir de la concepción de su estructura narrativa, la selección de sus objetos de exhibición y la puesta en escena, fortaleciendo así el pensamiento neoliberal que promulga la diversidad cultural como la sumatoria de culturas que comparten un mismo territorio, sin contradicciones, sin asimetrías, sin tensiones sociales, en una “paz social” aparente y en una relación natural con el entorno”</p><p>Cerrando este número presentamos un trabajo, una traducción y una Reseña bibliográfica incluida en la Sección Antropología Social. En el primer trabajo, Gastón Julián Gil propone un abordaje del fenómeno del running en la Argentina a partir del análisis de las carreras urbanas organizadas en las principales ciudades del país. Continúa una traducción realizada por Diego Roldán (CONICET) y Paul Hathazy (CIECS CONICET/UNC) del trabajo de Loic Wacquant “Por una Sociología de carne y sangre”, siendo ésta la primera versión publicada en español de este texto. Por último, Mariano Bussi presenta una reseña bibliográfica del trabajo de Renzo Taddei llamado Meteorologistas e profetas da chuva. Conhecimentos, práticas e políticas da atmosfera.</p><p>Con esto cerramos esta editorial invitando, como es usual, a disfrutar de la lectura crítica de este material que ponemos a disposición de los interesados.</p><p>Córdoba, 30 de Abril de 2019</p>
APA, Harvard, Vancouver, ISO, and other styles
42

Benavent, D., D. Capelusnik, D. Van der Heijde, R. B. M. Landewé, D. Poddubnyy, A. Van Tubergen, L. Falzon, S. Ramiro, and V. Navarro-Compán. "POS0963 HOW IS EARLY SPONDYLOARTHRITIS DEFINED IN THE LITERATURE? RESULTS FROM A SYSTEMATIC REVIEW." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 787.1–788. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1023.

Full text
Abstract:
BackgroundThe term “early spondyloarthritis (SpA)” has been frequently used to refer to the first phase of the disease, however, no standardized definition on “early” has been established. The ASAS-SPEAR (SPondyloarthritis EARly definition) project aims at developing a consensual definition on what is meant by “early SpA”. In order to inform the ASAS-SPEAR working group, it is highly relevant to assess the current meaning of “early SpA” in the literature.ObjectivesTo identify all possible definitions of “early SpA” employed in the literature, including “early axial SpA (axSpA)” and “early peripheral SpA (pSpA)”.MethodsA systematic literature review was conducted in Medline, EMBASE and the Cochrane Library (through April 28th, 2021). The eligibility criteria were studies with any design, in adults that included any mention of “early SpA” or its subtypes in the title or abstract. Two reviewers independently identified eligible studies and extracted data, including the literal definition of early SpA used in each of them. The proportion of studies reporting a definition was calculated, and the different definitions were assessed, including the core of the definition: whether they were based on symptom duration, disease duration, radiographic damage, a combination of them or any other aspects, and their boundaries.ResultsOut of 9,651 titles identified, 355 publications reporting data from 186 studies were included (291 full papers, 64 conference abstracts). Among them, 217 (61%) were cohort studies, 72 (20%) were reviews and 46 (13%) were clinical trials. Over time, an increasing number of publications on early SpA were identified: <2005 (n=34), 2005-2010 (n=48), 2011-2015 (n=109) and 2016-2020 (n=164). Overall, 63 studies (34%) included the term “early axSpA”, 60 (32%) “early ankylosing spondylitis (AS)”, 58 (31%) “early SpA”, 4 (2%) “early non-radiographic axSpA (nr-axSpA)” and 1 (1%) “early pSpA”. In total, 116 (62%) studies reported a specific definition: 40 (34%) based it on symptom duration, 35 (30%) on radiographic damage, 32 (28%) on disease duration, 6 (5%) on both symptom/disease duration and radiographic damage, and 3 (3%) on other aspects. Symptom duration was defined as the time since the onset of low back pain in 21/40 (53%) studies, whereas in 14/40 (35%) the symptom of onset was not specified. Thirty-five of 116 studies (30%) included a definition referred to “early SpA”, 38 (33%) to “early axSpA”, 38 (33%) to “early AS”, 4 (3%) to “early nr-axSpA”, and 1 (1%) to “early pSpA”. Figure 1 shows the 18 distinct definitions that were identified (after combining some similar categories). The three most used definitions per subtype of disease are shown in Table 1. Regarding the studies that referred to “early axSpA”, the most used definition was symptom/disease duration <5 years, whereas for “early AS” was symptom/disease duration <10 years. After 2010, the definition of “early axSpA” based on the absence of radiographic sacroiliitis was less used compared to before 2010 (5/30, 17% vs 3/8, 38%).Table 1.Top 3 candidate definitions for “early SpA” and subtypesCore of the definitionNumber of studies, n (%)SpA (n= 35)nr-axSpA10 (29%)< 2 years duration10 (29%)< 1 year duration6 (17%)AxSpA (n=38)< 5 years duration12 (34%)< 3 years duration9 (24%)nr-axSpA duration8 (21%)AS/r-axSpA (n=38)<10 years duration9 (24%)nr-axSpA7 (18%)< 2 years duration6 (16%)nr-axSpA (n=4)nr-axSpA2 (50%)< 1 year & nr-axSpA1 (25%)< 5 years & nr-axSpA1 (25%)pSpA (n=1)< 12 weeks duration1 (100%)“Duration” refers to symptom duration or disease duration.Figure 1.Number of studies stratified by the core of the definition.ConclusionOver time, the term “early SpA” and its subtypes are increasingly used. Despite addressing early SpA, more than one third of the studies did not include a clear definition of the term. The studies reporting a definition of early SpA showed a large heterogeneity, with two out of three of them based on the duration of symptoms or disease. These results emphasize the need for a standardised definition of early SpA.AcknowledgementsThe Assessment of Spondyloarthritis international Society (ASAS) supported Diego Benavent financially for this work.Disclosure of InterestsDiego Benavent Speakers bureau: Jannsen, Roche, Grant/research support from: Novartis., Dafne Capelusnik Speakers bureau: Bristol Myers Squibb, Pfizer, Grant/research support from: Pfizer, Désirée van der Heijde Consultant of: AbbVie, Bayer, BMS, Cyxone, Eisai, Galapagos, Gilead, Glaxo-Smith-Kline, Janssen, Lilly, Novartis, Pfizer, UCB Pharma., Employee of: Director of Imaging Rheumatology bv., Robert B.M. Landewé Consultant of: AbbVie, BMS, Galapagos, Gilead, GSK, Janssen, Lilly, Novartis, Pfizer, UCB, Denis Poddubnyy Speakers bureau: AbbVie, Bristol-Myers Squibb, Eli Lilly, MSD, Novartis, Pfizer, and UCB, Consultant of: AbbVie, Biocad, Eli Lilly, Gilead, GlaxoSmithKline, Janssen, MSD, Novartis, Pfizer, Samsung Bioepis, and UCB, Grant/research support from: AbbVie, Eli Lilly, MSD, Novartis, and Pfizer, Astrid van Tubergen Consultant of: Novartis, Galapagos, Grant/research support from: Pfizer, UCB, Novartis, Louise Falzon: None declared, Sofia Ramiro Speakers bureau: Eli Lilly, MSD, Novartis, UCB, Consultant of: AbbVie, Eli Lilly, MSD, Novartis, Pfizer, UCB, Sanofi, Grant/research support from: AbbVie, Galapagos, Novartis, Pfizer, UCB, Victoria Navarro-Compán Speakers bureau: AbbVie, Eli Lilly, Janssen, MSD, Novartis, Pfizer, UCB Pharma, Consultant of: AbbVie, Eli Lilly, MSD, Novartis, Pfizer, UCB Pharma, Grant/research support from: Abbvie and Novartis
APA, Harvard, Vancouver, ISO, and other styles
43

Garzón Díaz, Fabio Alberto. "¿Educación para la paz?" Revista Educación y Desarrollo Social 11, no. 2 (January 19, 2018): 5–19. http://dx.doi.org/10.18359/reds.3249.

Full text
Abstract:
El pasado 26 de septiembre de 2016, en el Patio de Banderas del Centro de Convenciones Julio César Turbay, en Cartagena, se realizó la firma protocolaria del Acuerdo Final de paz entre el Gobierno colombiano y el grupo guerrillero de las FARC. Este acto representó para los colombianos que nacimos después de 1964 (fecha de inicio de esta guerrilla) una luz de esperanza para estas generaciones que crecimos en pleno conflicto.Las generaciones que crecimos con el horror del crudo y sanguinario derrame de sangre de nuestros compatriotas fuimos las que por más de 50 años contemplamos el sufrimiento de madres viudas y de hijos huérfanos que no se explicaban ¡por qué les había tocado a ellos! Somos unas generaciones que crecimos con la demencia y esquizofrenia de la guerra.Ahora bien, no creo que exista algún ser racional que argumente que el cese de la guerra con las FARC sea una batalla perdida o una pérdida de la nuestra democracia. Para mí, como académico, fue la total victoria de la racionalidad dialógica versus la racionalidad instrumental, en palabras de Habermas. Con esto no quiero decir que todos los problemas se hayan resuelto y que el acuerdo sea perfecto, pero es una luz al final del túnel.Hoy estamos hablando de postconflico y de educación para la paz, y desde la editorial de la revista nos preguntamos: ¿qué significa una educación que promueva la paz? Se entiende por educación para la paz el proceso de adquisición de los valores y conocimientos, así como las actitudes, habilidades y comportamientos necesarios para conseguir la paz, entendida como vivir en armonía con uno mismo, los demás y el medio ambiente (Smith-Page, 2008).Sin embargo, este concepto no es nuevo. Ya la tradición griega se hacía las mismas preguntas: ¿para qué se ha de educar? ¿Por qué se tiene que educar? ¿Cómo se ha de educar? ¿A quién corresponde educar?Para Aristóteles (2014) educar es enseñar a vivir, pero no vivir de cualquier manera; educar para la vida es educar para ser feliz (I 13, 1102a26-3a10). El acento fuerte de Aristóteles es el concepto de felicidad (Eudaimonia): felicidad no es placer, riquezas, poder o el reconocimiento social, etc. La felicidad consistirá en un modo de vida adecuado al ser humano, en un modo de vivir digno y satisfactorio. Para Aristóteles (2006) lo que caracteriza al ser humano es la inteligencia y la razón; por lo tanto, su forma de vivir específicamente humana consistirá en vivir racionalmente. Esto último quiere decir cultivar el conocimiento, ejercitar la actividad intelectual, así como acomodar los deseos y las pasiones a los dictados de la razón (VII 15, 1334b15 ss.). ¿Hay algo más racional que la convivencia en paz y armonía?Presupuestos para una educación para la paz:1. Educar para la colaboración: el hombre está hecho para vivir en sociedad. La persona lleva en sí la necesidad de vivir en la dependencia, en la relación y en la mutua colaboración.2. Educación en los derechos humanos: “La educación tendrá por objeto el pleno desarrollo de la personalidad humana y el fortalecimiento del respeto a los derechos humanos y a las libertades fundamentales; favorecerá la comprensión, la tolerancia y la amistad entre las naciones y todos los grupos étnicos o religiosos, y promoverá el desarrollo de las actividades de las Naciones Unidas para el mantenimiento de la paz” (Declaración Universal de Derechos Humanos, 1948 Art. 26.2.).3. Educación en la libertad: “Todos los seres humanos deben estar en condiciones, gracias a la educación recibida en la juventud, de dotarse de 45 un pensamiento autónomo y crítico y de elaborar un juicio propio, para determinar por sí mismos qué deben hacer en las diversas circunstancias de la vida […] Más que nunca, la función esencial de la educación es conferir a todos los seres humanos la libertad de pensamiento, de juicio, de sentimientos y de imaginación que necesitan para que sus talentos alcancen la plenitud y seguir siendo artífices, en la medida de lo posible, de su destino” (Unesco, 1996, p. 12).4. Educación para la convivencia y la resolución de conflictos: la convivencia se enseña, se aprende, se va construyendo. El Informe de la Comisión Internacional de la Unesco sobre la educación del siglo XXI señala como una de los pilares básicos de la educación el aprender a convivir: “La educación a lo largo de la vida se basa en cuatro pilares: aprender a conocer, aprender a hacer, aprender a vivir juntos y aprender a ser(...) Aprender a vivir juntos desarrollando la comprensión del otro y la percepción de las formas de interdependencia (realizar proyectos comunes y prepararse para tratar los conflictos) respetando los valores de pluralismo, comprensión mutua y paz” (Cf. Garzón (2017), pp. 12 y ss).5. Educación en la tolerancia y el diálogo: las actitudes para una convivencia que intenta evitar la discriminación de las personas y de los grupos: • el PLURALISMO, que valora con la misma importancia la igualdad y la diversidad de los seres humanos; • la TOLERANICA de todo aquello que contradice nuestras ideas y valores; • el DIÁLOGO, como instrumento esencial en la resolución de los problemas sociales: El reconocimiento de la dignidad de la persona y de sus derechos fundamentales es el pilar básico de la convivencia humana y supone el principio de no discriminación y las actitudes de respeto, justicia y tolerancia (Declaración Universal de los Derechos Humanos, 1948. arts. 26 y ss).Debemos aprender a dialogar: “A dialogar también se aprende. No nacemos enseñados para casi nada. Tenemos que aprender obligatoriamente, si queremos seguir existiendo, las posibles respuestas a los diferentes estímulos. Por ello, en los humanos, los errores son más frecuentes que los aciertos, y decimos que aprendemos de aquéllos. Dialogar no es simplemente hablar. La presencia del otro, como interlocutor, establece unas condiciones que hay que respetar y, por tanto, aprender. Para que se produzca el diálogo, en tanto que comunicación interpersonal, se deben cumplir determinados requisitos. Es decir, se deben aprender unas actitudes y unas habilidades” (Ortega, Mínguez y Gil, 1996, p. 56).6. Educación para la democracia: esta última es, de hecho, una colección de desacuerdos basada en un único acuerdo: el de coexistir pese a todas las diferencias, sin que una mente trate de dominar a otras y sin que una posición trate de eliminar a otra o al poseedor de una mente distinta o de una posición diversa. La democracia es dos cosas: el derecho de cada persona a la igualdad y el igual derecho de ser diferente. Todo esto es posible únicamente si en el centro de nuestras diferentes convicciones religiosas, ideológicas, étnicas e históricas actuamos con tolerancia, y que esta vaya de persona a persona, de sociedad a sociedad, de país a país, de un lugar santo a otro lugar santo. (Simon Peres, ex-primer ministro de Israel)7. Educación en la ciudadanía: la educación para una ciudadanía activa comporta educar en valores democráticos, desarrollo moral y desarrollo de la competencia comunicativa —competencia ciudadana por excelencia—, aprendizajes para entender nuestro mundo y la participación en una ciudadanía colaborativa; pero, además, debe propiciar una ciudadanía reflexiva y responsable por saberse y sentirse interpelados por el otro: una ciudadanía ética (Martínez-Martín y Carreño-Rojas, 2014, pp. 153-160).8. Educación para la cooperación: “La cooperación entre niños es tan importante como la intervención de los adultos. Desde el punto de vista intelectual, es la más apta para favorecer el verdadero intercambio de ideas y discusión; es decir, todas las conductas capaces de educar la mente crítica, la objetividad y la reflexión discursiva. Desde el punto de vista moral, conduce a poner en práctica los principios que rigen una conducta, y no solo a una sumisión exterior” (Jean Piaget, citado en Zurbano, 1988).9. Educación para la solidaridad: la convivencia pacífica no es posible sin la solidaridad. En el concepto de solidaridad encontramos tres componentes esenciales: 1) compasión: la solidaridad supone, ante todo, un sentimiento de fraternidad, por el que uno siente afecto hacia los sufrimientos y necesidades de los demás como si fueran propios; 2) reconocimiento: para que esta genere solidaridad es preciso reconocer la dignidad personal de los otros. La solidaridad tiene así rostro: son otras personas, con la misma dignidad que yo, las que me interpelan desde sus necesidades y demandan de mí una respuesta; 3) universalidad: para ser solidario hay que tener sentimientos de compasión y de ayuda a toda la humanidad, sin fronteras de ninguna clase (políticas, religiosas, étnicas, culturales, económicas...), salvo una mayor sensibilidad por los más débiles y necesitados (Ortega, Mínguez y Gil, 1996).10. Educación para la Paz: 1) asumir la educación para la convivencia pacífica como opción educativa, con el compromiso de darle un tratamiento transversal; 2) analizar críticamente la realidad, con especial atención a todo lo relacionado con la convivencia de las personas, grupos y pueblos; 3) diseñar la educación para la convivencia pacífica que vamos a trabajar con los alumnos/as; 4) identificar la presencia de la educación para la convivencia pacífica en el currículo escolar; 5) insertar la educación para la convivencia pacífica en el currículo escolar y en las programaciones de aula (Zurbano, 1988).Estoy convencido de que educar para la paz es educar para formar ciudadanos íntegros y con múltiples valores; tiene, además, un componente fundamentalmente ético y, por consiguiente, político. La educación para la paz debería contribuir a buscar una justicia social con la todos los colombianos podamos vivir con los mínimos de dignidad y calidad de vida.
APA, Harvard, Vancouver, ISO, and other styles
44

Stephens, Danielle, Peter J. S. Fleming, Emma Sawyers, and Tim P. Mayr. "An isolated population reveals greater genetic structuring of the Australian dingo." Scientific Reports 12, no. 1 (November 9, 2022). http://dx.doi.org/10.1038/s41598-022-23648-1.

Full text
Abstract:
AbstractThe Australian dingo is a recent anthropogenic addition to the Australian fauna, which spread rapidly across the continent and has since widely interbred with modern dogs. Genetic studies of dingoes have given rise to speculation about their entry to the continent and subsequent biogeographic effects, but few studies of their contemporary population structure have been conducted. Here we investigated the dingo ancestry and population structure of free-living dogs in western Victoria and contrasted it with a wider southern Australian sample. We wished to determine whether their geographic isolation was mirrored in genetic isolation. To address this question, we analysed 34 microsatellite markers using Bayesian clustering and discriminant analysis of principal components, and summarised genetic diversity at the population and individual level. The broader southern Australia sample (n = 1138) comprised mostly hybrid animals, with 30% considered pure dingoes. All western Victorian individuals (n = 59) appeared to be hybrids with high dingo ancestry. The population showed no evidence of admixture with other populations and low genetic diversity on all measures tested. Based upon our characterisation of this unusual mainland population, we advise against assuming homogeneity of dingoes across the continent.
APA, Harvard, Vancouver, ISO, and other styles
45

Núñez Becerra, Fernanda. "Sobre: Helga Baitenmann, Victoria Chenaut y Ann Valery (eds.), Los códigos del género. Prácticas del derecho en el México contemporáneo." ULÚA. REVISTA DE HISTORIA, SOCIEDAD Y CULTURA, no. 17 (January 2, 2015). http://dx.doi.org/10.25009/urhsc.v0i17.1263.

Full text
Abstract:
El libro contiene 12 artículos escritos por las tres coordinadoras del libroChenaut, Baitenmann y Varley, más las participaciones de: Ana Alonso, Ivonne Szasz, Rosío Córdova, Lynn Stephen, María Teresa Sierra, Soledad González, Marta Lamas, Adriana Ortiz y Carmen Deere. Con un prefacio de la feminista, Maxine Molyneux y el pertinente epílogo de Jane Collier. Es un libro escrito por 14 especialistas mujeres, lo que puede mostrarnos que la investigación contemporánea sobre género, aunque sea cruzado con el derecho, sigue estando en manos de las propias mujeres. Felicitarnos por esa presencia femenina no debe impedir el preguntarnos: ¿no será que los hombres consideren el tema “poco digno”? Hace más de veinte años, la historiadora de las mujeres, Michelle Perrot, hacía la misma reflexión cuando afirmaba que la Historia con H mayúscula, seguía manteniendo los estudios sobre las mujeres y sobre el género, a pesar de algunos reconocimientos puntuales, en el rincón y no introducía en su relato general los novedosos descubrimientos que tanto la antropología como la historia estaban haciendo en ese campo.
APA, Harvard, Vancouver, ISO, and other styles
46

Plascencia, Arizbeth, Antonia Gutiérrez-Mora, José Manuel Rodríguez-Domínguez, José Juvencio Castañeda-Nava, Juan Gallardo-Valdez, Harumi Shimada, and Rosa María Camacho-Ruiz. "Molecular weight distribution of fructans extracted from <em>Agave salmiana</em> leaves." Botanical Sciences 1, no. 1 (March 22, 2022). http://dx.doi.org/10.17129/botsci.2960.

Full text
Abstract:
Background: In mezcal industry, Agave salmiana leaves are a crop residue and a potential source of fructans. Agave fructans are a soluble fiber that can act as prebiotic in gut microbiota. Questions and Hypotheses: The molecular weight distribution of agave fructans extracted from leaves of Agave salmiana depends on the region where agaves growth and on the subspecies. Studied species: Agave salmiana Otto ex Salm Dyck, spp. salmiana and Agave salmiana spp. crassispina. Study site: Twelve municipalities from Guanajuato México were sampled: Ocampo, San Felipe, San Diego de la Unión, Victoria, Xichú, Atarjea, Dolores Hidalgo, Doctor Mora, Santa Catarina, Tierra Blanca, San Miguel Allende and Comonfort. Methods: The base of the leaf close to the stem of Agave salmiana ssp. salmiana and A. salmiana ssp. crassispina plants, six years old, were harvested. Water soluble carbohydrates were extracted, the content molecular weight distribution of fructans was determined by HPLC-SEC. Results: An average of 0.7 % of soluble carbohydrates was recovered from the leaves. The molecular weight distribution of Agave salmiana fructans was: number average molecular weight: 3,209 g/mol; average molecular weight: 5,046 g/mol; number average degree of polymerization: 19; weight average degree of polymerization: 30. High polymerization degree fructans content was greater in Agave salmiana spp. salmiana (55 %) than in Agave salmiana spp. crassispina (47 %). Conclusions: The leaves of Agave salmiana contain a low proportion of high-molecular-weight fructans, compared to commercial agave fructans. The results demonstrated the technical feasibility to obtain fructans from Agave salmianaleaves.
APA, Harvard, Vancouver, ISO, and other styles
47

Doonan, Robert-James, Stamatios Theocharis, Claudia Cote, Yessica Gomez, and Stella S. Daskalopoulou. "Abstract 122: Circulating CD28- T Cells Are Associated with Histological Features of Carotid Plaque Instability." Arteriosclerosis, Thrombosis, and Vascular Biology 32, suppl_1 (May 2012). http://dx.doi.org/10.1161/atvb.32.suppl_1.a122.

Full text
Abstract:
Background: Circulating CD28- T-cells have been found to be higher in patients with acute coronary syndromes, suggesting a role for these cells in plaque instability. However, the association between circulating CD28- T-cells and carotid plaque instability as assessed by histology/immunohistochemistry has not been investigated. Methods/Results: 40 patients referred for carotid endarterectomy were recruited pre-operatively at the Royal Victoria Hospital in Montreal, Canada. A blood sample was obtained pre-operatively. Flow cytometry was performed on whole blood using a CD3, CD4, CD28 antibody cocktail (eBioscience, San Diego, United States) and a BD Bioscience (Mississauga, Canada) flow cytometer. Data was acquired as percentage of CD4+CD28- T-cells. The carotid plaque specimen was obtained from the operating room, fixed, decalcified, embedded in paraffin, and sections of 4μm were obtained from the site of maximum stenosis. Sections were stained with hematoxylin and eosin and with anti-CD3 (lymphocytes), anti-CD68 (macrophages/foam cells), and von Willebrand Factor (vWF, neovessels, all antibodies from Dako, Burlington, Canada). A vascular pathologist classified the plaques according to American Heart Association (AHA) classifications and graded CD3, CD68, and vWF staining on a semi-quantitative scale. Patients with more advanced lesions (AHA type 5 or 6) had a greater percentage of circulating CD4+CD28- T-cells [2.9% (2.7-5.7)] compared to patients with lower classifications [1.6% (1.0-4.2), P<0.05]. Furthermore, patients with plaques that had ≥10 new vessels per section (feature of plaque instability) had a median of 4.5% [2.8-8.0] CD4+CD28- T-cells whereas patients with <10 new vessels per section had only 2.3% [0.8-5.0] (P<0.05). There were no significant differences when patients were separated according to high/low plaque lymphocytes/macrophages. Conclusion: We have shown that circulating CD28- T-cells are found in greater amounts in patients who have more advanced/unstable carotid plaques as assessed by histology and immunohistochemistry. This may point to a role for CD28- T-cells in the pathogenesis of atherosclerosis. Further studies are currently being carried out to confirm these results.
APA, Harvard, Vancouver, ISO, and other styles
48

Rosenthal, Mariane D’Avila, Mari Lúcie Da Silva Loretto, and Eduarda Azevedo Gonçalves. "A REPRESENTAÇÃO DE MENDIGOS EM OBRAS DE ARTISTAS." Seminário de História da Arte - Centro de Artes - UFPel, no. 6 (July 3, 2017). http://dx.doi.org/10.15210/sha.v0i6.11538.

Full text
Abstract:
Representar a figura de “Mendigos” se constitui em uma forma de pensar e produzir artisticamente algo que seja uma imagem acordada com a cotidiana realidade, contextos sociais e artísticos e por questões poéticas podendo inclusive envolver aspectos particulares da vida do artista e desses grupos sociais que vivem em indigência ou mendicância material que se relacionam a condição de habitantes andarilhos, maltrapilhos, “sem teto” ou “sem abrigo”. Os processos, a tecnologia, a materialidade, a linguagem escolhida pelos artistas e as diferentes maneiras de “dar a ver” essa vulnerabilidade social desde remotos tempos na linha histórica da arte mostram que a temática em torno dessa condição social não se esgota. Neste trabalho apresentamos algumas obras dos artistas Vincent Van Gogh, El Greco, Pieter Brughel, Bartolomé Esteban Murillo, Rembrandt Van Rijn, Pablo Picasso, Francisco de Goya y Lucientes, Honoré-Victorien Daumier, Lasar Segal, Diego Rivera e Dorothea Lange. Podemos observar que a vulnerabilidade e condição de risco social estão relacionadas a construção estética dos mendigos, proporcionando que sejamos capazes de observa-los através da historia da arte como figuras urbanas marginalizadas, relacionadas a um contexto de exclusão, marginalização ou indigência social por razões socioeconômicas e que transitavam e transitam próximos a centros urbanos. Desta forma, o artigo tem por objetivo mostrar esta temática associada também a produção de artistas contemporâneos como Mathieu Pernot e Francys Allys, revelando um outro sujeito que mendiga e que é classificado como “PESSOA EM SITUAÇÃO DE RUA” valendo destas figuras como elementos visuais que intrigam e provocam dentro de um contexto de descompromisso e insalubridade.
APA, Harvard, Vancouver, ISO, and other styles
49

Arepalli, Sruthi, and Peter K. Kaiser. "Pipeline therapies for neovascular age related macular degeneration." International Journal of Retina and Vitreous 7, no. 1 (October 1, 2021). http://dx.doi.org/10.1186/s40942-021-00325-5.

Full text
Abstract:
AbstractAge related macular degeneration (AMD) is the most common cause of vision loss in the elderly population. Neovascular AMD comprises 10% of all cases and can lead to devastating visual loss due to choroidal neovascularization (CNV). There are various cytokine pathways involved in the formation and leakage from CNV. Prior treatments have included focal laser therapy, verteporfin (Visudyne, Bausch and Lomb, Rochester, New York) ocular photodynamic therapy, transpupillary thermotherapy, intravitreal steroids and surgical excision of choroidal neovascular membranes. Currently, the major therapies in AMD focus on the VEGF-A pathway, of which the most common are bevacizumab (Avastin; Genentech, San Francisco, California), ranibizumab (Lucentis; Genentech, South San Francisco, California), and aflibercept (Eylea; Regeneron, Tarrytown, New York). Anti-VEGF agents have revolutionized our treatment of wet AMD; however, real world studies have shown limited visual improvement in patients over time, largely due to the large treatment burden. Cheaper alternatives, including ranibizumab biosimilars, include razumab (Intas Pharmaceuticals Ltd., Ahmedabad, India), FYB 201 (Formycon AG, Munich, Germany and Bioeq Gmbh Holzkirchen, Germany), SB-11 (Samsung Bioepsis, Incheon, South Korea), xlucane (Xbrane Biopharma, Solna, Sweden), PF582 (Pfnex, San Diego, California), CHS3551 (Coherus BioSciences, Redwood City, California). Additionally, aflibercept biosimilars under development include FYB203 (Formycon AG, Munich, Germany and Bioeq Gmbh Holzkirchen, Germany), ALT-L9 (Alteogen, Deajeon, South Korea), MYL1710 (Momenta Pharamaceuticals, Cambridge, MA, and Mylan Pharmacueticals, Canonsburg, PA), CHS-2020 (Coherus BioSciences, Redwood City, California). Those in the pipeline of VEGF targets include abicipar pegol (Abicipar; Allergan, Coolock, Dublin), OPT-302 (Opthea; OPTHEA limited; Victoria, Melbourne), conbercept (Lumitin; Chengdu Kanghong Pharmaceutical Group, Chengdu, Sichuan), and KSI-301 (Kodiak Sciences, Palo Alto, CA). There are also combination medications, which target VEGF and PDGF, VEGF and tissue factor, VEGF and Tie-2, which this paper will also discuss in depth. Furthermore, long lasting depots, such as the ranibizumab port delivery system (PDS) (Genentech, San Francisco, CA), as well as others are under evaluation. Gene therapy present possible longer treatments options as well and are reviewed here. This paper will highlight the past approved medications as well as pipeline therapies for neovascular AMD.
APA, Harvard, Vancouver, ISO, and other styles
50

Weinberg, Laurence, Dominic Walpole, Dong Kyu Lee, Michael D'Silva, Jian Wen Chan, Lachlan Fraser Miles, Bradly Carp, et al. "Modern Cardiac Surgical Outcomes in Nonagenarians: A Multicentre Retrospective Observational Study." Frontiers in Cardiovascular Medicine 9 (July 14, 2022). http://dx.doi.org/10.3389/fcvm.2022.865008.

Full text
Abstract:
BackgroundThere have been multiple recent advancements in the selection, optimisation and management of patients undergoing cardiac surgery. However, there is limited data regarding the outcomes in nonagenarians, despite this cohort being increasingly referred for these interventions. The objective of this study was to describe the patient characteristics, management and outcomes of a cohort of nonagenarians undergoing cardiac surgery receiving contemporary peri-operative care.MethodsAfter receiving ethics approval, we conducted a retrospective observational study of nonagenarians who had undergone cardiac surgery requiring a classic median sternotomy. All operative indications were included. We excluded patients who underwent transcatheter aortic valve implantation (TAVI), and surgery on the thoracic aorta via an endovascular approach (TEVAR). Patients undergoing TEVAR often have the procedure done under sedation and regional blocks with local anesthetic solution. There is no open incision and these patients do not require cardiopulmonary bypass. We also excluded patients undergoing minimally invasive mitral valve surgery via a videoscope assisted approach. These patients do not have a median sternotomy, have the procedure done via erector spinae block, and often are extubated on table. Data were collected from four hospitals in Victoria, Australia, over an 8-year period (January 2012–December 2019). The primary objective was to assess 6-month mortality in nonagenarian patients undergoing cardiac surgery and to provide a detailed overview of postoperative complications. We hypothesized that cardiac surgery in nonagenarian patients would be associated with a 6-month postoperative mortality &lt;10%. As a secondary outcome, we hypothesized that significant postoperative complications (i.e., Clavien Dindo Grade IIIb or greater) would occur in &gt; 30% of patients.ResultsA total of 12,358 adult cardiac surgery patients underwent surgery during the study period, of whom 18 nonagenarians (0.15%) fulfilled inclusion criteria. The median (IQR) [min-max] age was 91.0 years (90.0:91.8) [90–94] and the median body mass index was 25.0 (kg/m2) (22.3:27.0). Comorbidities, polypharmacy, and frailty were common. The median predicted mortality as per EuroSCORE-II was 6.1% (4.1:14.5). There were no cases of intra-operative, in-hospital, or 6-month mortality. One (5.6%) patient experienced two Grade IIIa complications. Three (16.7%) patients experienced Grade IIIb complications. Three (16.7%) patients had an unplanned hospital readmission within 30 days of discharge. The median value for postoperative length of stay was 11.6 days (9.8:17.6). One patient was discharged home and all others were discharged to an inpatient rehabilitation facility.ConclusionIn this selected, contemporary cohort of nonagenarian patients undergoing cardiac surgery, postoperative 6-month mortality was zero. These findings support carefully selected nonagenarian patients being offered cardiac surgery (Trials Registry: https://www.anzctr.org.au/ACTRN12622000058774.aspx).
APA, Harvard, Vancouver, ISO, and other styles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography