Academic literature on the topic 'Dimsym for reduce'

Abstract. The basis and challenge of strongly coupled data assimilation (CDA) is the accurate representation of cross-domain covariances between various coupled subsystems with disparate spatio-temporal scales, where often one or more subsystems are unobserved. In this study, we explore strong CDA using ensemble Kalman filtering methods applied to a conceptual multiscale chaotic model consisting of three coupled Lorenz attractors. We introduce the use of the local attractor dimension (i.e. the Kaplan–Yorke dimension, dimKY) to prescribe the rank of the background covariance matrix which we construct using a variable number of weighted covariant Lyapunov vectors (CLVs). Specifically, we consider the ability to track the nonlinear trajectory of each of the subsystems with different variants of sparse observations, relying only on the cross-domain covariance to determine an accurate analysis for tracking the trajectory of the unobserved subdomain. We find that spanning the global unstable and neutral subspaces is not sufficient at times where the nonlinear dynamics and intermittent linear error growth along a stable direction combine. At such times a subset of the local stable subspace is also needed to be represented in the ensemble. In this regard the local dimKY provides an accurate estimate of the required rank. Additionally, we show that spanning the full space does not improve performance significantly relative to spanning only the subspace determined by the local dimension. Where weak coupling between subsystems leads to covariance collapse in one or more of the unobserved subsystems, we apply a novel modified Kalman gain where the background covariances are scaled by their Frobenius norm. This modified gain increases the magnitude of the innovations and the effective dimension of the unobserved domains relative to the strength of the coupling and timescale separation. We conclude with a discussion on the implications for higher-dimensional systems.

One of the popular methods of asynchronous logic implementation is based on so called Delay-Insensitive-Minterm-System (DIMS), where a sum-of-minterms (SOM) function is given and each minterm is represented using a state-holding (C-) element. However, such implementation is rather expensive since minterm minimization is not allowed. In the paper, structure called factorized DIMS is proposed. It is shown that under realistic delay limitation, instead of SOM, strong indication can be ensured for the sum of mutually orthogonal product terms resolved into factorized form. It reduces significant implementation complexity.

XTRONIC®, a tailored nanocrystalline nickel alloy, has been qualified as a new metal barrier layer replacing pure nickel in many traditional hard and soft gold applications. XTRONIC is produced using a proprietary combination of electroplating chemistry and pulse-reverse applied current waveforms that enables dynamic control of the deposited material's composition and grain structure. The resulting deposits have been shown to provide superior performance in a variety of areas that are critical to microelectronics. These improved performance metrics include resistance to corrosive environments, wear durability, wire bonding, and temperature aging performance. The novel suites of properties possible provide enhanced performance for microelectronics, and can also enable equivalent or improved overall performance even with significant reductions of precious metal use in many applications. Proven areas of application include high-speed backplane connectors and multiple printed circuit board applications such as dual in-line memory module (DIMM) and flash memory card (FMC) applications. In the current paper we focus on properties for printed circuit board applications.

Aim. To evaluate how health-related quality of life (HRQOL) and traditional Chinese medicine (TCM) constitutions of Yin-Xu, Yang-Xu, and Stasis are related in type 2 diabetes patients. Method. Seven hundred and five subjects were recruited in 2010 for this study from a Diabetes Shared Care Network in Taiwan. Generic and disease-specific HRQOL were assessed by the short form 36 (SF-36) and the diabetes impact measurement scale (DIMS). Constitutions of Yin-Xu, Yang-Xu, and Stasis were then assessed by the body constitution questionnaire (BCQ), a questionnaire consisting of 44 items that evaluate the physiological state based on subjective symptoms and signs. Results. Estimated effects of the Ying-Xu and Stasis on all scales of the SF-36 were significantly negative, while estimated effects of the Yang-Xu on all scales (except for SF, RE, MH, and MCS) were significantly negative. For DIMS, the estimated effects of the Ying-Xu and Stasis on all scales were significantly negative except for Stasis on well-being, while Yang-Xu has a significantly negative effect only on symptoms. Conclusions. This study demonstrates that TCM constitutions of Yin-Xu, Yang-Xu, and Stasis are closely related to a reduction in HRQOL. These findings support the need for further research into the impact of intervention for TCM constitutions on HRQOL in patients with type 2 diabetes.

During the recent decades, non-volatile memory (NVM) has been anticipated to scale up the main memory size, improve the performance of applications, and reduce the speed gap between main memory and storage devices, while supporting persistent storage to cope with power outages. However, to fit NVM, all existing DRAM-based applications have to be rewritten by developers. Therefore, the developer must have a good understanding of targeted application codes, so as to manually distinguish and store data fit for NVM. In order to intelligently facilitate NVM deployment for existing legacy applications, we propose a universal heterogeneous cache hierarchy which is able to automatically select and store the appropriate data of applications for non-volatile memory (UHNVM), without compulsory code understanding. In this article, a program context (PC) technique is proposed in the user space to help UHNVM to classify data. Comparing to the conventional hot or cold files categories, the PC technique can categorize application data in a fine-grained manner, enabling us to store them either in NVM or SSDs efficiently for better performance. Our experimental results using a real Optane dual-inline-memory-module (DIMM) card show that our new heterogeneous architecture reduces elapsed times by about 11% compared to the conventional kernel memory configuration without NVM.

Objectives The aim of this study was to compare the stress reduction effects of spending 25 minutes reclining in a SolTec™ Lounge between 2 intervention groups. Group 1 experienced the Lounge with multilayered music on an external speaker, while group 2 experienced the Lounge with multilayered music and synchronous vibration and magnetic stimulation from within the chair. Subjects In total, 110 participants with a self-reported stress level of 4 or higher on a 0- to 10-point scale were recruited from the local community including employees. Participants were randomized into receiving 1 of the 2 interventions. There were no significant differences between the group’s average stress levels prior to the interventions. Interventions Both groups received a 25-minute session in a dimly lit, quiet area on the Lounge with multilayered music. The second group also received vibration and magnetic stimulation that were synchronized with the music. Design Current stress level as well as ratings or feelings of anxiety, tenseness, energy, focus, happiness, relaxation, nervousness, creativeness, and being rested were recorded before and after the session. Results Both groups of participants reported equivalent decreased feelings of stress after using the Lounge. Participants receiving the synchronous multilayered music, vibration, and magnetic stimulation did report significantly reduced feelings of tenseness, feeling more relaxed, and feeling more creative when compared with the group that received music only. Conclusion Spending 25 minutes in the SolTec™ Lounge with multilayered music is an effective way to reduce self-reported stress in individuals who self-report having a high stress level. If confirmed by future studies, including synchronous vibration and magnetic stimulation with the multilayered music might be an effective stress reduction strategy.

AbstractLet M be a geometrically irreducible smooth projective variety, defined over a finite field k, such that M admits a k-rational point x0. Let (M,x0/ denote the corresponding fundamental group-scheme introduced by Nori. Let EG be a principal G-bundle over M, where G is a reduced reductive linear algebraic group defined over the field k. Fix a polarization ξ on M. We prove that the following three statements are equivalent:1. The principal G-bundle EG over M is given by a homomorphism (M,x0)→G.2. There are integers b > a ≥ 1, such that the principal G-bundle (FbM)* EG is isomorphic to (FaM) * EG where FM is the absolute Frobenius morphism of M.3. The principal G-bundle EG is strongly semistable, the degree(c2(ad(EG))c1 (ξ)d−2 = 0, where d = dimM, and the degree(c1(EG(χ))c1(ξ)d−1) = 0 for every character χ of G, where EG(χ) is the line bundle over M associated to EG for χ.In [16], the equivalence between the first statement and the third statement was proved under the extra assumption that dimM = 1 and G is semisimple.

Abstract Abstract 3805 Background: Detection of aberrant antigen expression by multiparameter flow cytometry (MFC) is increasingly used in the diagnostic work-up of myelodysplastic syndromes (MDS). Myeloid nuclear differentiation antigen (MNDA) has been described to be strongly expressed in mature myeloid cells while myeloid progenitor cells show a weak expression only. MNDA has been suggested to be aberrantly expressed in MDS and therefore may improve the diagnostic capabilities of MFC. Aim: To analyze differences in the expression of MNDA between non-MDS cytopenias, MDS, and AML. Patients and methods: Bone marrow samples from a total of 269 patients with cytopenias and suspected MDS were analyzed by cytomorphology and MFC in parallel for diagnostic purposes. MNDA expression was determined by MFC in granulocytes, monocytes, and myeloid progenitor cells using the antibody clone 3C1 (provided by Trillium Diagnostics, Bangor, ME). MNDA expression was compared between patients grouped according to cytomorphology as: no MDS (n=103), MDS (n=85), CMML (n=9), AML (n=19), and possible MDS (n=53, based on cytomorphologic features of dysplasia but not sufficient to diagnose MDS). In addition, MNDA expression was compared between patients with aberrant and normal karyotype (cytogenetics was available in 238/269 patients, an aberrant karyotype was present in 59 patients). Results: A higher percentage of granulocytes (G) and monocytes (M) with weak expression of MNDA (%dimG and %dimM) was consistently found in MDS/AML samples as compared to samples without MDS. In detail, %dimG (mean±SD, 20±20% vs. 8±10%, p<0.001) and %dimM (31±24% vs. 16±11%, p<0.001) were significantly higher in cases with MDS as compared to those without. Furthermore, in patients with MDS, as compared to those without, the mean fluorescence intensity (MFI) of MNDA expression was found to be lower in monocytes (mean MFI, 71±36 vs. 85±27, p=0.004) as well as in myeloid progenitor cells with bright (67±24 vs. 86±66, p=0.007) or dim (2.5±0.9 vs. 2.8±1.2, p=0.037) expression of MNDA. In AML cases, as compared to cases with no MDS, similar figures were observed with higher values for %dimG (27±27% vs. 8±10%, p=0.007) and for %dimM (45±31% vs. 16±11%, p=0.001). In addition, in AML cases MFI of MNDA expression was lower in monocytes (55±39 vs. 85±27, p<0.001). Considering the diagnostically challenging cases with dysplastic features by cytomorphology but not sufficient to diagnose MDS similar although smaller differences were seen as compared to cases with no MDS with higher values for both %dimG (15±22% vs. 8±10%, p=0.026) and %dimM (25±19% vs. 16±11%, p=0.002) as well as a lower MFI of MNDA expression in monocytes (73±26 vs. 85±27, p=0.010). Interestingly, in CMML cases no reduced expression of MNDA could be found in any of the cell lines analyzed which might argue in favour of regarding CMML as myeloproliferative rather than myelodysplastic disease. From the cytogenetic point of view cases with an aberrant karyotype had higher values for both %dimG (22±20% vs. 12±18%, p=0.001) and %dimM (33±24% vs. 23±21%, p=0.004) as compared to those with a normal karyotype. Conclusions: These data suggests that MDS, as compared to non-MDS bone marrow, is associated with a reduced expression of MNDA in different cell lines which in part also applies to AML. Further analyses should define the potential of MNDA assessment to improve the MFC-based approach to diagnose MDS. Disclosures: Kern: MLL Munich Leukemia Laboratory: Employment, Equity Ownership. Bellos:MLL Munich Leukemia Laboratory: Employment. Alpermann:MLL Munich Leukemia Laboratory: Employment. Haferlach:MLL Munich Leukemia Laboratory: Employment, Equity Ownership. Schnittger:MLL Munich Leukemia Laboratory: Employment, Equity Ownership. Haferlach:MLL Munich Leukemia Laboratory: Employment, Equity Ownership.

Abstract Background: Diagnostic workup for suspected myelodysplastic syndromes (MDS) is increasingly done with the aid of multiparamter flow cytometry (MFC) detecting aberrant antigen expression. Myeloid nuclear differentiation antigen (MNDA) is a hematopoietic protein expressed strongly in mature myeloid cells, but only weakly in myeloid progenitor cells. Recently, reduced MNDA expression was detected by MFC in monocytes (M), granulocytes (G) and myeloid progenitor cells (MP) in patients (pts) with MDS and MNDA as additional marker for MFC was proposed to improve diagnostic capabilities of MFC. Aim: To verify differences in MNDA expression in M, G and MP of pts with MDS vs. those without MDS and to test its value as additional MFC parameter in a cohort with suspected MDS. Patients and methods: We analysed bone marrow from 131 pts (median age 74, range 17-93 years) with suspected MDS by cytomorphology (CM), standard 10-color-MFC and cytogenetics (CG) in parallel. For detection of MNDA expression we applied a readily available five color intracellular staining assay using monoclonal antibodies against MNDA, CD45, CD64, CD15 and myeloperoxidase (MDS-Quant, Trillium Diagnostics, Bangor, ME). Different gating strategies to best define M [SSC/CD45 plot (A) vs CD16/CD15 plot (B)], G (A vs B) and MP (A) were used. MNDA expression in pts diagnosed with no MDS (n=35), possible MDS (n=40; based on morphologic dysplastic changes insufficient for diagnosis of MDS) and MDS (n=56) by CM was compared. We also correlated results to findings in standard MDS-MFC (n=128) and CG (n=120). Results: Based on CM diagnosis, pts with MDS showed higher percentages of G and M with weak expression of MNDA (%dimG and %dimM) than no-MDS pts irrespective of the gating strategy [mean±SD, %dimG: 16±17 vs 6±7, p<0.001 (A) and 3±3 vs 1±2, p=0.011 (B); %dimM: 22±21 vs 15±12, p=0.054 (A) and 14±25 vs 4±4, p=0.004 (B)]. Diagnostically challenging cases with "possible MDS" by CM also displayed significantly higher %dimG and %dimM than no-MDS cases [%dimG 13±14 vs 6±7, p=0.006 (A), %dimM: 23±20 vs 15±12, p=0.027 (A) and 17±24 vs 4±4, p=0.002 (B)]. Differences between MDS and possible MDS existed only in higher %dimGra in MDS gated in plot B (2.7±3.3 vs 1.6±1.9, p=0.036). Conversely, MDS pts and pts with possible MDS had higher percentages of MP with high MNDA expression (%hiMP) than no-MDS pts (17±16 vs 9±8, p=0.005 and 14±13 vs 9±8, p=0.041, respectively). MNDA expression levels measured by mean fluorescence intensity (MFI) were diminished in M of pts with MDS vs no-MDS [26±12 vs 33±9, p=0.006 (A) and 30±14 vs 39±10, p=0.002 (B), respectively] and in pts with possible MDS vs no-MDS pts [26±12 vs 33±9, p=0.004 (A) and 30±2 vs 39±10, p=0.005, respectively]. Looking at the low level MNDA MP (dimMP), higher MFIs were found in MDS compared to no-MDS (1±0.8 vs 0.7±0.4, p=0.002) and in possible MDS vs no-MDS (1.0±0.7 vs 0.7±0.4, p=0.011). Comparing results of MNDA MFC and standard MFC we also found higher MFI in dimMP (1.0±0.8 vs 0.7±0.3, p=0.039) in pts diagnosed MDS by MFC (n=63) vs those without signs of MDS (n=14). In the inexplicit cases diagnosed MDS possible by MFC (aberrant antigen expressions not sufficient for MDS diagnosis, n=51) higher percentages of dimG [16±18 vs 9±10, p=0.015 (A) and 3±3 vs 1±2, p=0.005 (B)] and dimM [16±25 vs 7±13, p=0.02 (B)] were seen as compared to no-MDS, in line with CM results. Moreover, a lower MFI in M [26±12 vs 31±11, p=0.024 (A) and 29±14 vs 36±13, p=0.02 (B)] and a higher MFI in dimMP (1.0±0.8 vs 0.9±0.6, p=0.021) could be detected. Considering CG, cases with an aberrant karyotype (n=41) had higher values for %dimM (27±23 vs 18±16, p=0.035) as compared to those with a normal karyotype (n=79). Including the most significant markers [%dimG>12 (A), %dimM>13 (B), %hiMP>15 (A), 1 point each], we created a new MNDA score with a score of ≥2 indicating MDS. Of 14 pts with a score of ≥2, 13 pts were concordantly diagnosed MDS using CM for validation; 1 pt had no MDS by CM but was classified MDS by standard MDS-MFC. Conclusions: Reduced MNDA levels and higher percentages of M and G with low MNDA expression as well as a higher percentage of MP with high MNDA expression could be confirmed in pts with MDS. Applying our newly defined MNDA score for MFC, identification of a subset of pts with MDS was possible at high specificity. Further analyses will have to evaluate this MNDA score incorporated into standard MDS-MFC panels to improve MFC-based diagnostic approaches for MDS. Disclosures Bellos: MLL Munich Leukemia Laboratory: Employment. Haferlach:MLL Munich Leukemia Laboratory: Employment, Equity Ownership. Davis:Trillium Diagnostics: Employment, Equity Ownership. Haferlach:MLL Munich Leukemia Laboratory: Employment, Equity Ownership. Schnittger:MLL Munich Leukemia Laboratory: Employment, Equity Ownership. Kern:MLL Munich Leukemia Laboratory: Employment, Equity Ownership.

The recent explosion of thin notebooks and tablets has challenged the IC packaging industry to come up with new solutions of DRAM integration onto motherboard. Beyond traditional SO-DIMMs, innovative memory solutions should perform well at high speed (1600 MT/s) with much reduced footprint and z-height, while leveraging current manufacturing infrastructure for lower cost and also enabling simpler and cheaper motherboard design. To accomplish all the goals stated above for high-performance on-board memory applications, we showed a new DIMM-in-a-Package (DIAP) technology. This 22.5×17.5×1.2mm quad-die face-down (QFD) part has four standard center bond DDR3L dies (each ×16) face-down, which are wire-bonded to the bottom layer of the 407-ball BGA package. This judiciously designed package places data nets at the peripheral and command/control/address nets in the middle of the BGA. As such, motherboard design and layout were substantially simplified to allow the use of low-cost non-HDI Type 3 board for signal integrity performance comparable to expensive HDI boards. The QFD™ ball assignment could accommodate future memory density expansion and different memory type (e.g. LPDDR3, DDR4). It also enables dual-rank operations in each channel when double-sided assembly is used. We successfully demonstrated in production build that 1GB ×64 DDR3L QFD with data rate of 1600 MT/s can be achieved on a Type 3 motherboard for the Intel Haswell mobile platform in dual-channel dual-rank operation. A balanced-T Command/Address topology between the processor and the memory was implemented in a DELL XPS 12 Ultrabook. Channel simulations including chip, package and board were performed. We also conducted cross-talk analysis up to 9 aggressors to take into account the timing impact from the dense routing inside QFD. Layout optimization techniques for best signal integrity, such as trace length matching and stub length minimization, were discussed in detail and applied to both package and motherboard design. Lastly, we also presented and discussed DIAPs currently under study with different memory bus topologies for even higher data rate up to 2400 MT/s using the same QFD technology. Our results and analysis demonstrated DIAP using wirebond-based QFD technology as a viable candidate for the compact, low-cost, high-performance on-board memory solution. We have identified several key aspects of DIAP architecture design and physical layout that are strongly impacting the SI of QFD parts at rate &gt;1600 MT/s and that could be optimized for DDR4 operations. QFD DIAP can become an attractive low-cost, high-performance option for many OEMs and ODMs in various mobile, personal and network computing platforms.

This study presents a theoretical basis for and outlines the method of finding the Lie point symmetries of systems of partial differential equations. It seeks to determine which of five computer algebra packages is best at finding these symmetries. The chosen packages are LIEPDE and DIMSYM for REDUCE, LIE and BIGLIE for MUMATH, DESOLV for MAPLE, and MATHLIE for MATHEMATICA. This work concludes that while all of the computer packages are useful, DESOLV appears to be the most successful system at determining the complete set of Lie symmetries. Also, the study describes REDUCEVAR, a new package for MAPLE, that reduces the number of independent variables in systems of partial differential equations, using particular Lie point symmetries. It outlines the results of some testing carried out on this package. It concludes that REDUCEVAR is a very useful tool in performing the reduction of independent variables according to Lie's theory and is highly accurate in identifying cases where the symmetries are not suitable for finding S/G equations.