Relevant bibliographies by topics / Dihydropyrrolone

Academic literature on the topic 'Dihydropyrrolone'

Author: Grafiati
Published: 4 June 2021
Last updated: 9 February 2022

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Journal articles on the topic "Dihydropyrrolone"

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Melekhina, Valeriya G., Andrey N. Komogortsev, Boris V. Lichitsky, Vitaly S. Mityanov, Artem N. Fakhrutdinov, Arkady A. Dudinov, Vasily A. Migulin, Yulia V. Nelyubina, Elizaveta K. Melnikova, and Michail M. Krayushkin. "One-pot synthesis of substituted pyrrolo[3,4-b]pyridine-4,5-diones based on the reaction of N-(1-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-2-oxo-2-arylethyl)acetamide with amines." Beilstein Journal of Organic Chemistry 15 (November 25, 2019): 2840–46. http://dx.doi.org/10.3762/bjoc.15.277.

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The condensation of primary amines with N-(1-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-2-oxo-2-arylethyl)acetamides was explored. Thus, a previously unknown recyclization of the starting material was observed in acidic ethanol in the presence of an amine, which provided the corresponding dihydropyrrolone derivative as the major reaction product. Based on this transformation, a practical and convenient one-pot synthetic method for substituted pyrrolo[3,4-b]pyridin-5-ones could be devised.
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Ho, Kitty Ka Kit, Nerida Cole, Renxun Chen, Mark D. P. Willcox, Scott A. Rice, and Naresh Kumar. "Immobilization of Antibacterial Dihydropyrrol-2-ones on Functional Polymer Supports To Prevent Bacterial InfectionsIn Vivo." Antimicrobial Agents and Chemotherapy 56, no. 2 (December 5, 2011): 1138–41. http://dx.doi.org/10.1128/aac.05814-11.

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ABSTRACTAntibiotic-resistantStaphylococcus aureusis of great concern, as it causes a wide range of life-threatening infections. The current study demonstrates that dihydropyrrolone (DHP)-coated polyacrylamide substrates are effective in reducing the number of culturable clinical isolates ofS. aureusin vitroin a dose-dependent manner and are able to reduce the pathogenic potential of staphylococcal infection in a subcutaneous infection model. Covalently bound DHPs therefore show great potential for use as an antimicrobial strategy in device-related applications.
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Tian, Shuanbao, and Yongbing Hao. "Sulfuric Acid-Modified Polyethylene Glycol 6000 Catalyzed Synthesis of Dihydropyrrolone." Chinese Journal of Organic Chemistry 33, no. 10 (2013): 2232. http://dx.doi.org/10.6023/cjoc201304040.

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Pandya, Keyur, Bhavesh Dave, Rajesh Patel, and Piyush Desai. "In Silico Approach Towards the Prediction of Drug-likeness, in Vitro Microbial Investigation and Formation of Dihydropyrrolone Conjugates." Advanced Journal of Chemistry-Section A 3, no. 4 (June 1, 2020): 378–90. http://dx.doi.org/10.33945/sami/ajca.2020.4.1.

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Biletzki, Tobias, Thomas Elschner, Toni Neuwirth, Helmar Görls, and Wolfgang Imhof. "Synthesis and structural characterization of imines from 2,3-diphenylbutane-1,4-diamine and their ruthenium catalyzed transformation to bis-(1,3-dihydropyrrolone) derivatives." Arkivoc 2012, no. 3 (July 15, 2012): 457–69. http://dx.doi.org/10.3998/ark.5550190.0013.331.

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Singh, Mandavi, Shyam Babu Singh, Shahin Fatma, Preyas Ankit, and Jagdamba Singh. "Development of five membered heterocyclic frameworks via [3+2] cycloaddition reaction in an aqueous micellar system." New J. Chem. 38, no. 7 (2014): 2756–59. http://dx.doi.org/10.1039/c4nj00325j.

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A series of novel dihydropyrrolo[2,1-a]isoquinolines and dihydropyrrolo[1,2-a]quinolines have been synthesized from isoquinolines/quinolines, various substituted phenacyl bromides and substituted dialkylacetylenedicarboxylates via [3+2] cycloaddition reaction.
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Kreher, Richard P., and Gerald Dyker. "Struktur und Reaktivität von isoanellierten heterocyclischen Systemen mit Anπ- und (4n+2)π-Elektronen, XII [1]. 2-tert-Butyl-4-methyl-2,4-dihydropyrrolo[3,4-b]indole: Tricyclische Hetarene mit isoanellierten Pyrrolringen / Structure and Reactivity of Isoannelated Heterocyclic Systems with 4nπ- and (4n+2)π-Electrons, XII [1] 2-terr-Butyl-4-methyl-2,4-dihydropyrrolo[3,4-b]indoles: Tricyclic Hetarenes with Isoannelated Pyrrole Rings." Zeitschrift für Naturforschung B 42, no. 4 (April 1, 1987): 473–77. http://dx.doi.org/10.1515/znb-1987-0414.

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2-tert-Butyl-4-methyl-2,4-dihydropyrrolo[3,4-b]indole (4a) has been prepared via selective reduction of 2-rm-butyl-4-methyl-2,4-dihydropyrrolo[3,4-b]indol-l(2H)-one or -3(2H)-one 5 and 6 with diisobutylaluminiumhydride. The same precursors 5 and 6 can be transformed into 2-tert-butyl-4-methyl-2,4-dihydropyrrolo[3,4-b]indoles (4b) and (4c) bearing a methoxy group in 1- or 3-position via a two step procedure consisting in O-alkylation and CH-deprotonation. NMR Investigations afford an insight into the structure of the stable tricyclic hetarenes.
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Guo, Yong En, Xiao Guang Niu, Cai Ju Zhou, Jie Chu, Wei Wei Xu, and Guo Zhen Fang. "Design and Preparation of 1H-3, 4-Dihydropyrrolo[1,2-a] Pyrazin-1-One via 1H-3,4-Dihydropyrrolo[1,2-C] [1,4] Oxazin-1-One Route." Advanced Materials Research 343-344 (September 2011): 1242–47. http://dx.doi.org/10.4028/www.scientific.net/amr.343-344.1242.

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With 2-pyrrolyltrichloroacetone as major starting material, unreported 1H-3,4-dihydropyrrolo- [1,2-a]pyrazin-1-one was prepared successively by its monoesterification with ethylene glycol, bromine displacement of hydroxy group, cyclization to lactone and its amidation. Unreported 7-aroyl-1H-3,4-dihydropyrrolo[1,2-c][1,4]oxazin-1-one compounds were also synthesized in turn by 2-pyrrolyl-trichloroacetone’s Friedel-Crafts acylation and cyclization. Their structures were characterized by IR, 1H NMR, 13C NMR, MS, HRMS, etc.
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Liao, Shao Han, Dai Hua Hu, Ai Ling Wang, and De Peng Li. "Novel 5,6-Dihydropyrrolo[2,1-a]isoquinolines as Scaffolds for Synthesis of Lamellarin Analogues." Evidence-Based Complementary and Alternative Medicine 2011 (2011): 1–6. http://dx.doi.org/10.1155/2011/103425.

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As core skeletons of lamellarins: 5,6-Dihydropyrrolo[2,1-a]isoquinolines are one of the important alkaloids that exhibit significant biological activities, in this study, an efficient synthetic route was described for two novel compounds, 5,6-dihydropyrrolo[2,1-a]isoquinolinesIandII. CompoundIwas synthesized from isovanillin with 28.3% overall yield by a six-step reaction whileIIfrom 2-(3,4-dimethoxyphenyl) ethanamine was with 61.6% overall yield by a three-step reaction. And the structures of these two compounds were confirmed by means of IR spectrum,1H NMR,13C NMR, MS, HRMS, and melting point measurements.
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Belguedj, Roumaissa, Sofiane Bouacida, Hocine Merazig, Ali Belfaitah, Aissa Chibani, and Abdelmalek Bouraiou. "Synthesis and crystal structures of three novel benzimidazole/benzoindolizine hybrids." Zeitschrift für Naturforschung B 71, no. 3 (March 1, 2016): 231–39. http://dx.doi.org/10.1515/znb-2015-0164.

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AbstractThree benzoindolizine derivatives, 1, 2, and 3, were obtained via 1,3-dipolar cycloaddition. The reaction of 1-(2′-benzimidazolylmethyl)isoquinolinium ylides with dimethyl acetylenedicarboxylate gave a mixture of pyrrolo[2,1-a]isoquinoline-1,2-dicarboxylate (1) and 1,10b-dihydropyrrolo[2,1-a]isoquinoline-1,2-dicarboxylate (2) derivatives containing a benzimidazole moiety. The reaction of this isoquinolinium N-ylide with dimethyl maleate gave an unexpected 2,3-dihydropyrrolo[2,1-a]isoquinoline-1,2-dicarboxylate (3). The structures of all reported compounds have been examined by X-ray crystallography, mass spectrometry, and NMR spectroscopy.
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Dissertations / Theses on the topic "Dihydropyrrolone"

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Goh, Wai Kean Chemistry Faculty of Science UNSW. "Novel antagonists of bacterial signaling pathways." Publisher:University of New South Wales. Chemistry, 2008. http://handle.unsw.edu.au/1959.4/41458.

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Traditional bacterial disease therapies utilize compounds that ultimately kill the target bacteria but it exerts a strong selective pressure on the bacteria to develop multi-drug resistance mutants. The increasing occurrence of resistance in common pathogens has highlighted the need to identify new anti-microbials that target the control of bacterial pathogenicity in a non-extermination manner to reduce the incidence of bacteria resistance. One new strategy exploits the discrete signaling molecules that regulate the various bacterial signaling pathways, which are responsible for the expression of pathogenicity traits. Halogenated furanones (fimbrolides) from the marine red alga, Delisea pulchra have been shown to interfere with the key signaling pathway present in Gram-negative bacteria by competitively displacing the cognate signaling molecule from the transcription protein. This project focused on the design and synthesis of 1,5-dihydropyrrol-2-ones, a new class of fimbrolide derivatives capable of displaying strong antagonistic properties of the fimbrolides. Primary synthetic methodologies examined include the halolactamization of allenamides and the direct lactone-lactam transformation. No doubt, both methodologies yielded the lactam ring, the former failed to introduce the crucial C-5 bromomethylene group essential for bioactivity. A facile high yielding two-step lactone-lactam transformation method was developed and using this method, a wide range of substituted 5-bromomethyl- and 5-dibromomethylene-1,5-dihydropyrrol-2-ones were synthesized. Furthermore, a new class of tricyclic crown-ether type compounds with no literature precedent were discovered. To vary the diversity of the compounds, a related class of compounds, 5,6-dihydroindol-2-ones, were examined. A general versatile method for the synthesis of 7-substituted 5,6-dihydroindol-2-ones was developed. The synthetic strategy proceeds via the established Suzuki-Miyaura cross-coupling reaction of halogenated dihydroindol-2-ones with arylboronic acids/esters. The Suzuki methodology was found to be reliable in furnishing a wide range of 7-substituted products in high yields. A preliminary molecular modeling approach was used to assist in the design of new anti-microbials via the ligand-docking analyses of the TraR and LasR protein. A positive correlation was observed between the docking scores and biological activity and the methodology was further developed into an initial screening tool to filter potential active and non-active compounds. The newly synthesized compounds were analysed for their efficacy in reducing the expression of the Green Fluorescent Protein (GFP) in the presence of natural AHL signaling molecules in an AHL-monitor strain, indicative of the inhibition of bacterial phenotype expression. The dihydropyrrol-2-one class of compounds showed significant biological activity and this highlighted their potential for further development.
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Martins, Lucas Michelão. "Estudos sobre a utilização do pentacloreto de nióbio, como ácido de Lewis, visando a síntese de derivados de tetra-aril-1,4-di-hidropirrol[3,2-b]pirroles, com potencial aplicação como corantes sensibilizadores em dispositivos eletrônicos orgânicos." Universidade Estadual Paulista (UNESP), 2018. http://hdl.handle.net/11449/153679.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Nesse trabalho nós apresentamos uma metodologia para a síntese dos derivados de tetra-aril-1,4-di-hidropirrol[3,2-b]pirroles através de uma reação multicomponente entre derivados de benzaldeído, derivados de anilina e a butano-2,3-diona promovida pelo pentacloreto de nióbio em condições brandas e com excelentes rendimentos, entre59 e 98% e com baixos tempos reacionais, de 20 a40 minutos. Uma comparação entre os resultados deste estudo e os encontrados na literatura para a síntese multicomponente de tetra-aril-1,4-di-hidropirrol[3,2-b]pirroles promovida por ácidos de Lewis também fez parte deste trabalho, e pudemos concluir que o pentacloreto de nióbio é muito eficiente nessa síntese, já que permite um maior rendimento em menor tempo reacional que os outros ácidos. Também apresentamos a caracterização óptica dos produtos sintetizados, com espectroscopia de absorção na região do UV-Vis e de fluorescência, onde observamos que os compostos sintetizados apresentaram valores comparáveis aos tieno[3,2-b]tiofenos e aos indolo[3,2-b]indoles, ambos sendo compostos que apresentam aplicações em dispositivos eletrônicos orgânicos.
In this work we report a method for the synthesis of tetraaryl-1,4-dihydropyrrolo-[3,2-b]pyrroles derivatives through a multicomponent reaction between benzaldehyde derivatives, aniline derivatives and butane-2,3-dione promoted by niobium pentachloride, in mild conditions with excellent yields, between 59 and 98% and low reaction times, from 20 to 40minutes. A comparison between our results and the ones found in the literature for the synthesis of tetraaryl-1,4-dihydropyrrolo-[3,2-b]pyrroles derivatives using different Lewis acids was also in the scope of this work, and we could conclude that niobium pentachloride is very efficient for these synthesis, since it gives better yields in lower time. We also show the optical characterization of the synthesized products, with UV-vis and fluorescence spectroscopy, where we could observe that the synthesized compounds presented values comparable with thieno[3,2-b]thiophenes and indolo[3,2-b]indoles, both having applications in organic electronic devices.
FAPESP 16/01599-1
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Semyonov, Alexander N. "Design, Synthesis and Characterization of Fluorescent Dyes and Liquid Crystal Semiconductors." Kent State University / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=kent1153556141.

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Charavin, Marine. "Synthèse d'agonistes non-peptidiques du récepteur à la prokinéticine PKR1." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAF047/document.

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Les récepteurs couplés aux protéines G représentent la plus grande famille de récepteurs membranaires. Parmi eux, nous avons choisi d’étudier deux récepteurs apparentés : les récepteurs de la prokinéticine 1 et 2. Ces deux récepteurs ont pour ligands des hormones de nature peptidique, divisées en deux sous-groupes : les prokinéticines 1 et 2. Ces deux prokinéticines sont impliquées dans plusieurs processus physiologiques en se liant à leurs récepteurs PKR1 et PKR2. Il a été récemment montré que la prokinéticine 2 pouvait stimuler la prolifération et la différenciation des cellules souches progénitrices cardiaques, via les récepteurs PKR1 et PKR2. Il a également été reporté que l’activation de PKR1 protège les cardiomyocytes et les cellules progénitrices cardiaques de l’apoptose. Afin d’étudier ces effets nous avons synthétisé des agonistes non-peptidiques du récepteur PKR1. Nous avons donc poursuivi les études de pharmacomodulation d’une première famille de composés et développé une seconde famille d’agonistes potentiels originaux, déterminée par des études de modélisation moléculaire. Une sonde fluorescente a été synthétisée afin d’évaluer la liaison de nouveaux composés. Au cours de ces travaux nous avons découvert une nouvelle réaction multi-composante permettant la synthèse d’un composé dihydropyrrole polyfonctionnel. Nous nous sommes alors intéressés à son mécanisme et à sa limitation chimique dans le but de former de nouveaux hétérocycles fonctionnalisés
The G protein-coupled receptors represent the largest familly of membrane receptors. Among them,we choose to study two related receptors: prokineticin receptors 1 and 2. These two receptors have peptidic hormone ligands, divided in two sub-groups: prokineticins 1 and 2. Both prokineticins are involved in many physiological processes by binding to their receptors PKR1 and PKR2. It has recently been shown that prokineticin 2 could stimulate proliferation and differentiation of cardiac progenitor cells. It was also reported that activation of PKR1 protects cardiomyocytes and cardiac progenitor cells from apoptosis. To investigate these effects we synthesized non-peptidic receptor PKR1. We continued pharmacodulation studies of a first familly of compounds and developped a second familly of original potential agonists, determined by molecular modeling studies. A fluorescent probe was synthesized to access the binding of novel compounds. During this work we discovered a new multi-component reaction for the synthesis of a polyfunctional dihydrpyrrol compound. We then interested in the mechanism and its chemical limitation in order to form new functionalized heterocycles
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Wu, Jia-Ying, and 吳佳穎. "Synthesis and Optoelectronic Properties of 2,5-Disubstituted of 1,4-dihydropyrrolo [3,2-b] pyrrole." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/24104226104492632213.

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碩士
國立臺灣大學
高分子科學與工程學研究所
103
A series of compounds with pyrrolo [3,2-b] pyrrole-centered have been synthesized, containing triphenylamine, carbazole, and thiophene group at the 2, 5-position. The electrochemical, photophysics and photochemistry properties were investigated. Compound 4 have show potential for electrochemical polymerization, and its electrochromic mechanism has been studied. Compound 1 in the environment with halides proceeds a photochemical reaction and is observed change color. The possible reaction mechanism have been studied by UV-Vis-NIR spectrum analysis, and further used to detect halide, which can visually identify chloroform in water to lowest concentration of 8 ppm. Additionally, this series of compounds have strong fluorescence intensity, having potential to be novel dyes in the application of photovoltaic materials.
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Book chapters on the topic "Dihydropyrrolone"

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Gallagher, P. T. "Diels–Alder Reactions of 2,4-Dihydropyrrolo[3,4-]indoles." In Fused Five-Membered Hetarenes with One Heteroatom, 1. Georg Thieme Verlag KG, 2001. http://dx.doi.org/10.1055/sos-sd-010-00881.

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Pfeiffer, W. D. "4,5-Dihydropyrrolo[3,2-]benzoselenazoles and 4,5-Dihydroselenazolo[4,5-]quinolines." In Five-Membered Hetarenes with One Chalcogen and One Additional Heteroatom, 1. Georg Thieme Verlag KG, 2002. http://dx.doi.org/10.1055/sos-sd-011-01221.

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Schantl, J. G. "Reaction of Dihydropyrrole-Substituted α-Oxo Esters and Acylhydrazines Followed by Intramolecular [3 + 2] Cycloaddition." In Heteroatom Analogues of Aldehydes and Ketones, 1. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-027-00655.

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