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1

Hayden, J. H. "The application of video-enhanced constrast/differential interference constrast microscopy in conjunction with whole mount electron microscopy to the study of organelle transport." Proceedings, annual meeting, Electron Microscopy Society of America 46 (1988): 66–67. http://dx.doi.org/10.1017/s0424820100102419.

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In a previous study, Allen video-enhanced constrast/differential interference constrast (AVEC-DIC) microscopy was used in conjunction with immunofluorescence microscopy to demonstrate that organelles and vesicle move in either direction along linear elements composed of microtubules. However, this study was limited in that the number of microtubules making up a linear element could not be determined. To overcome this limitation, we have used AVEC-DIC microscopy in conjunction with whole mount electron microscopy.Keratocytes from Rana pipiens were grown on glass coverslips as described elsewher
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Su, Hongsheng, Dantong Wang, and Xuping Duan. "Condition Maintenance Decision of Wind Turbine Gearbox Based on Stochastic Differential Equation." Energies 13, no. 17 (2020): 4480. http://dx.doi.org/10.3390/en13174480.

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Maintenance decision analysis is necessary to ensure the safe and stable operation of wind turbine equipment. To address gearboxes with a high failure rate in wind turbines, this paper establishes a new stochastic differential equation model of gearbox state transition to maximize the utilization of gearboxes. This model divides the state of the gearbox into two parts: internal degradation and external random interference. Weibull distribution and polynomial approximation were used to construct the internal degradation model of the gearbox. The external random interference is simulated by Brow
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DE SILVA, T. MIHIRI M., and SOPHIA R. J. JANG. "STOCHASTIC MODELING OF PHYTOPLANKTON–ZOOPLANKTON INTERACTIONS WITH TOXIN PRODUCING PHYTOPLANKTON." Journal of Biological Systems 26, no. 01 (2018): 87–106. http://dx.doi.org/10.1142/s0218339018500055.

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We construct models of continuous-time Markov chain (CTMC) and Itô stochastic differential equations of population interactions based on a deterministic system of two phytoplankton and one zooplankton populations. The mechanisms of mutual interference among the predator zooplankton and the avoidance of toxin-producing phytoplankton (TPP) by zooplankton are incorporated. Sudden population extinctions occur in the stochastic models that cannot be captured in the deterministic systems. In addition, the effect of periodic toxin production by TPP is lessened when the birth and death of the populati
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Zhang, Hao, Lihua Dou, Chunxiao Cai, and Bin Xin. "Three-Dimensional Unmanned Aerial Vehicle Route Planning Using Hybrid Differential Evolution." Journal of Advanced Computational Intelligence and Intelligent Informatics 24, no. 7 (2020): 820–28. http://dx.doi.org/10.20965/jaciii.2020.p0820.

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Unmanned aerial vehicles (UAVs) have been investigated proactively owing to their promising applications. A route planner is key to UAV autonomous task execution. Herein, a hybrid differential evolution (HDE) algorithm is proposed to generate a high-quality and feasible route for fixed-wing UAVs in complex three-dimensional environments. A multiobjective function is designed, and both the route length and risk are optimized. Multiple constraints based on actual situations are considered, including UAV mobility, terrain, forbidden flying areas, and interference area constraints. Inspired by the
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Wang, Renqiang, Huaran Yan, Qinrong Li, Yubo Deng, and Yutong Jin. "Parameters Optimization-Based Tracking Control for Unmanned Surface Vehicles." Mathematical Problems in Engineering 2022 (March 18, 2022): 1–13. http://dx.doi.org/10.1155/2022/2242338.

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In this paper, a type of tracking controller on the basis of parameters optimization was proposed for unmanned surface vehicles (USVs). Taking into account the unique nonlinear and large inertia characteristics of USVs, an iterative sliding mode control (ISMC) was adopted to construct the controller including the USVs’ main engine speed controller to determine the longitudinal velocity and the steering controller to control the lateral displacement. In designing, the hyperbolic tangent function with the saturation characteristic is introduced to design the output feedback control law of nonlin
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6

Zheng, Xiaoxia, Shuai Wang, and Yiqun Qian. "Fault feature extraction of wind turbine gearbox under variable speed based on improved adaptive variational mode decomposition." Proceedings of the Institution of Mechanical Engineers, Part A: Journal of Power and Energy 234, no. 6 (2019): 848–61. http://dx.doi.org/10.1177/0957650919885720.

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This paper proposes a study on gearbox fault feature extraction of wind turbine under variable speed condition using improved adaptive variational mode decomposition (VMD). Frequent changes in wind speed and critical noise interference make the vibration signal exhibit non-stationary characteristics. Although computational order tracking can transform non-stationary signals in the time domain into stationary angular signals, and then extract fault features from order spectrum obtained by FFT, the obtained order spectrum is liable to be polluted by noise or to appear order aliasing. To avoid or
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7

Sheng, Wei, Zhengminqing Li, Hong Zhang, and Rupeng Zhu. "Geometry and design of spur gear drive associated with low sliding ratio." Advances in Mechanical Engineering 13, no. 4 (2021): 168781402110125. http://dx.doi.org/10.1177/16878140211012547.

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The relative sliding between tooth surfaces is the main cause of tooth wear and power loss, which directly affects the transmission efficiency and durability of gear. The aim of this paper is to provide a method to design such spur gear with low sliding ratio (LSR). Based on kinematics, differential geometry and contact path, the general mathematical models of the generating rack, the pinion and the mating gear tooth profiles are established in turn. Then, according to the relationship between the contact path and sliding ratio, a contact path described by a cubic function is proposed to const
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Fan, Zifu, Youpeng Tao, Wei Zhang, Kexin Fan, and Jiaojiao Cheng. "Research on open and shared data from government-enterprise cooperation based on a stochastic differential game." AIMS Mathematics 8, no. 2 (2022): 4726–52. http://dx.doi.org/10.3934/math.2023234.

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<abstract> <p>Based on the perspective of government and enterprises, we explore the cooperative strategy and cost-sharing problem of cooperative open sharing of data between government and enterprises. In order to accurately analyze the data-opening strategies of government and enterprises, stochastic differential game theory is applied to construct the Nash non-cooperative game, Stackelberg master-slave game and cooperative game models with government and enterprises as game subjects to obtain the optimal open data effort, the optimal trajectory of social data open sharing level
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9

Zhu, Fang-Jun, Lu-Juan Zhou, Mi Zhou, and Feng Pei. "FINANCIAL DISTRESS PREDICTION: A NOVEL DATA SEGMENTATION RESEARCH ON CHINESE LISTED COMPANIES." Technological and Economic Development of Economy 27, no. 6 (2021): 1413–46. http://dx.doi.org/10.3846/tede.2021.15337.

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In the Chinese stock market, the unique special treatment (ST) warning mechanism can signal financial distress for listed companies. In existing studies, classification model has been developed to differentiate the two general listing states. However, this classification model cannot explain the internal changes of each listing state. Considering that the requirement of the withdrawal of ST in the mechanism is relatively loose, we propose a new segmentation approach for Chinese listed companies, which are divided into negative companies and positive companies according to the number of times b
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10

Selçuk, Kadir, Hilal Kivrak, and Nahit Aktaş. "Novel CNT Supported Molybdenum Catalyst for Detection of L-Cysteine in Its Natural Environment." Catalysts 11, no. 12 (2021): 1561. http://dx.doi.org/10.3390/catal11121561.

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In this study, novel carbon nanotube-supported Mo (Mo/CNT) catalysts were prepared with the sodium borohydride reduction method for the detection of L-cysteine (L-Cys, L-C). Mo/CNT catalysts were characterized with scanning electron microscopy with elemental dispersion X-ray (EDX-SEM), X-ray diffraction (XRD), UV-vis diffuse reflectance spectrometry (UV-vis), temperature-programmed reduction (TPR), temperature programmed oxidation (TPO), and temperature-programmed desorption (TPD) techniques. The results of these advanced surface characterization techniques revealed that the catalysts were pre
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11

GRIGORIEVA, NATALIE S., and GREGORY M. FRIDMAN. "ASYMPTOTIC BEHAVIOR OF SOLUTIONS OF THE HELMHOLTZ EQUATION CONCENTRATED NEAR THE AXIS OF A DEEP-WATER WAVEGUIDE IN A RANGE-INDEPENDENT MEDIUM." Journal of Computational Acoustics 12, no. 01 (2004): 67–83. http://dx.doi.org/10.1142/s0218396x04002171.

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To derive the integral representation for the axial wave describing the interference of near-axial waves in an arbitrary deep-water waveguide in a range-independent medium in long-range acoustic propagation in the ocean, it is necessary to construct the solutions of the homogeneous Helmholtz equation concentrated near the waveguide axis in a narrow strip having a width of order ω-1/2, where ω is a cyclic frequency. In a range-independent (separable) case the desired solutions coincide with the principal term of the uniform asymptotic expansion as ω→∞ of normal modes when a mode number is a val
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12

Ye, Qing, and Nancy Lan Guo. "Hub Genes in Non-Small Cell Lung Cancer Regulatory Networks." Biomolecules 12, no. 12 (2022): 1782. http://dx.doi.org/10.3390/biom12121782.

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There are currently no accurate biomarkers for optimal treatment selection in early-stage non-small cell lung cancer (NSCLC). Novel therapeutic targets are needed to improve NSCLC survival outcomes. This study systematically evaluated the association between genome-scale regulatory network centralities and NSCLC tumorigenesis, proliferation, and survival in early-stage NSCLC patients. Boolean implication networks were used to construct multimodal networks using patient DNA copy number variation, mRNA, and protein expression profiles. T statistics of differential gene/protein expression in tumo
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13

Prokopidis, Konstantinos, Panagiotis Giannos, Oliver C. Witard, Daniel Peckham, and Theocharis Ispoglou. "Aberrant mitochondrial homeostasis at the crossroad of musculoskeletal ageing and non-small cell lung cancer." PLOS ONE 17, no. 9 (2022): e0273766. http://dx.doi.org/10.1371/journal.pone.0273766.

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Cancer cachexia is accompanied by muscle atrophy, sharing multiple common catabolic pathways with sarcopenia, including mitochondrial dysfunction. This study investigated gene expression from skeletal muscle tissues of older healthy adults, who are at risk of age-related sarcopenia, to identify potential gene biomarkers whose dysregulated expression and protein interference were involved in non-small cell lung cancer (NSCLC). Screening of the literature resulted in 14 microarray datasets (GSE25941, GSE28392, GSE28422, GSE47881, GSE47969, GSE59880 in musculoskeletal ageing; GSE118370, GSE33532,
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14

Chien, Wei, Tzong-Tyng Hsieh, Chien-Ching Chiu, Yu-Ting Cheng, Yang-Han Lee, and Qiang Chen. "Theoretical Derivation and Optimization Verification of BER for Indoor SWIPT Environments." Symmetry 12, no. 7 (2020): 1185. http://dx.doi.org/10.3390/sym12071185.

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Symmetrical antenna array is useful for omni bearing beamforming adjustment with multiple receivers. Beam-forming techniques using evolution algorithms have been studied for multi-user resource allocation in simultaneous wireless information and power transfer (SWIPT) systems. In a high-capacity broadband communication system there are many users with wearable devices. A transmitter provides simultaneous wireless information and power to a particular receiver, and the other receivers harvest energy from the radio frequency while being idle. In addition, the ray bounce tracking method is used t
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15

Chen, Chun-Hui, Neelanjan Akuli, Yu-Jen Lu, and Chia-Ming Yang. "Laser Illumination Adjustments for Signal-to-Noise Ratio and Spatial Resolution Enhancement in Static 2D Chemical Images of NbOx/IGZO/ITO/Glass Light-Addressable Potentiometric Sensors." Chemosensors 9, no. 11 (2021): 313. http://dx.doi.org/10.3390/chemosensors9110313.

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In a previous study, a thin In-Ga-Zn-oxide light addressable potentiometric sensor (IGZO LAPS) was indicated to have the advantages of low interference from ambient light, a high photocurrent and transfer efficiency, and a low cost. However, illumination optimization to obtain two-dimensional (2D) chemical images with better spatial resolutions has not been fully investigated. The trigger current and AC-modulated frequency of a 405-nm laser used to illuminate the fabricated IGZO LAPS were modified to check the photocurrent of the sensing area and SU8–2005 masking area, obtaining spatial resolu
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16

Wang, Lei, Shibao Li, Chaoqun Teng, et al. "Automatic-Detection Method for Mining Subsidence Basins Based on InSAR and CNN-AFSA-SVM." Sustainability 14, no. 21 (2022): 13898. http://dx.doi.org/10.3390/su142113898.

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Mining subsidence disasters are common geological disasters. Accurate and effective identification of their deformation position is significant in preventing and controlling geological disasters and monitoring illegal mining. In this study, deep learning, combined with a support vector machine (SVM), has been used to establish an automatic-detection method for mining subsidence basins using Sentinel-1A data. The Huainan mining area was selected as the experimental area to verify the method. The interferogram was obtained using differential radar interferometry (D-InSAR) to process the Sentinel
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17

Singh, Biswajit, Smita Pal (Sarkar), and Krishnendu Barman. "Memory-dependent derivative under generalized three-phase-lag thermoelasticity model with a heat source." Multidiscipline Modeling in Materials and Structures 16, no. 6 (2020): 1337–56. http://dx.doi.org/10.1108/mmms-10-2019-0182.

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PurposeThis study aims to attempt to construct a new mathematical model of the generalized thermoelasiticity theory based on the memory-dependent derivative (MDD) considering three-phase-lag effects. The governing equations of the problem associated with kernel function and time delay are illustrated in the form of vector matrix differential equations. Implementing Laplace and Fourier transform tools, the problem is sorted out analytically by an eigenvalue approach method. The inversion of Laplace and Fourier transforms are executed, incorporating series expansion procedures. Displacement comp
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18

Huang, Jing, Xiaodong Li, Casey A. Maguire, Russell Hilf, Robert A. Bambara та Mesut Muyan. "Binding of Estrogen Receptor β to Estrogen Response Element in Situ Is Independent of Estradiol and Impaired by Its Amino Terminus". Molecular Endocrinology 19, № 11 (2005): 2696–712. http://dx.doi.org/10.1210/me.2005-0120.

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Abstract The functions of 17β-estradiol (E2) are mediated by estrogen receptor (ER) α and β. ERs display similar DNA- and ligand-binding properties in vitro. However, ERβ shows lower transcriptional activity than ERα from the estrogen response element (ERE)-dependent signaling. We predicted that distinct amino termini contribute to differences in transcription efficacies of ERs by affecting in situ ER-ERE interactions. We used chromatin immunoprecipitation and a novel in situ ERE competition assay, which is based on the ability of ER to compete for ERE binding with a designer activator that co
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19

Harb, Jason, Paolo Neviani, Claudia Huettner, Guido Marcucci, and Danilo Perrotti. "BCR/ABL Dosage Hierarchically and Temporally Influences hnRNP A1, hnRNP K and hnRNP E2 Expression in Hematopoietic Stem and Progenitor Cells." Blood 114, no. 22 (2009): 191. http://dx.doi.org/10.1182/blood.v114.22.191.191.

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Abstract Abstract 191 The molecular mechanism leading to the progression of chronic myelogenous leukemia (CML) from the indolent chronic phase (CML-CP) to the rapidly fatal blast crisis (CML-BC) are still unclear although a plausible assumption is that enhanced expression of BCR/ABL, as that observed in most of patients undergoing progression, represents the factor promoting clonal evolution of CML. Given that a) BCR/ABL levels are increased in the CML-BC stem/leukemia-initiating cell population; b) a causal relationship exists between levels and activity of the BCR/ABL oncoprotein and aberran
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20

Zhu, Xueliang, Dasen Wang, Mengyao Zhang, et al. "Optimization of wavefront reconstruction accuracy for conjugate shift differential absolute testing." Scientific Reports 12, no. 1 (2022). http://dx.doi.org/10.1038/s41598-022-26380-y.

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AbstractThe conjugate shift differential method, based on Fourier transforms, is critical for surface error testing of high-precision optical elements. However, this common approach is also prone to periodic spectrum loss. As such, this paper proposes conjugate double shift differential (CDSD) absolute testing, which can effectively compensate for spectrum loss and achieve accurate wavefront reconstructions. Spectrum loss in the single shift differential method is analyzed through a study of the Fourier reconstruction process. A calculation model for the proposed CDSD method is then establishe
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Li, Yue, Ye Liu, Mengjie Duo, et al. "Bioinformatic analysis and preliminary validation of potential therapeutic targets for COVID-19 infection in asthma patients." Cell Communication and Signaling 20, no. 1 (2022). http://dx.doi.org/10.1186/s12964-022-01010-2.

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Abstract Background Severe acute respiratory syndrome coronavirus 2 causes coronavirus disease 19 (COVID-19). The number of confirmed cases of COVID-19 is also rapidly increasing worldwide, posing a significant challenge to human safety. Asthma is a risk factor for COVID-19, but the underlying molecular mechanisms of the asthma–COVID-19 interaction remain unclear. Methods We used transcriptome analysis to discover molecular biomarkers common to asthma and COVID-19. Gene Expression Omnibus database RNA-seq datasets (GSE195599 and GSE196822) were used to identify differentially expressed genes (
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Shi, Guolong, Xinyi Shen, Huan Ren, Yuan Rao, Shizhuang Weng, and Xianghu Tang. "Kernel principal component analysis and differential non-linear feature extraction of pesticide residues on fruit surface based on surface-enhanced Raman spectroscopy." Frontiers in Plant Science 13 (July 19, 2022). http://dx.doi.org/10.3389/fpls.2022.956778.

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Surface-enhanced Raman spectroscopy (SERS) has attracted much attention because of its high sensitivity, high speed, and simple sample processing, and has great potential for application in the field of pesticide residue detection. However, SERS is susceptible to the influence of a complex detection environment in the detection of pesticide residues on the surface of fruits, facing problems such as interference from the spectral peaks of detected impurities, unclear dimension of effective correlation data, and poor linearity of sensing signals. In this work, the enhanced raw data of the pestic
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23

Joerk, Alexander, Marcel Ritter, Niklas Langguth, et al. "Propentdyopents as Heme Degradation Intermediates Constrict Mouse Cerebral Arterioles and Are Present in the Cerebrospinal Fluid of Patients With Subarachnoid Hemorrhage." Circulation Research 124, no. 12 (2019). http://dx.doi.org/10.1161/circresaha.118.314160.

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Rationale: Delayed ischemic neurological deficit is the most common cause of neurological impairment and unfavorable prognosis in patients with subarachnoid hemorrhage (SAH). Despite the existence of neuroimaging modalities that depict the onset of the accompanying cerebral vasospasm, preventive and therapeutic options are limited and fail to improve outcome owing to an insufficient pathomechanistic understanding of the delayed perfusion deficit. Previous studies have suggested that BOXes (bilirubin oxidation end products), originating from released heme surrounding ruptured blood vessels, are
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24

Zhao, Enshuang, Hao Zhang, Xueqing Li, Tianheng Zhao, and Hengyi Zhao. "Construction of sRNA Regulatory Network for Magnaporthe oryzae Infecting Rice Based on Multi-Omics Data." Frontiers in Genetics 12 (November 12, 2021). http://dx.doi.org/10.3389/fgene.2021.763915.

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Studies have shown that fungi cause plant diseases through cross-species RNA interference mechanism (RNAi) and secreted protein infection mechanism. The small RNAs (sRNAs) of Magnaporthe oryzae use the RNAi mechanism of rice to realize the infection process, and different effector proteins can increase the autotoxicity by inhibiting pathogen-associated molecular patterns triggered immunity (PTI) to achieve the purpose of infection. However, the coordination of sRNAs and proteins in the process of M. oryzae infecting rice is still poorly understood. Therefore, the combination of transcriptomics
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25

Meng, Kai, Jinghe Cao, Yehao Dong, Mengchen Zhang, Chunfeng Ji, and Xiaomei Wang. "Application of Bioinformatics Analysis to Identify Important Pathways and Hub Genes in Ovarian Cancer Affected by WT1." Frontiers in Bioengineering and Biotechnology 9 (October 6, 2021). http://dx.doi.org/10.3389/fbioe.2021.741051.

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Wilms tumor gene (WT1) is used as a marker for the diagnosis and prognosis of ovarian cancer. However, the molecular mechanisms involving WT1 in ovarian cancer require further study. Herein, we used bioinformatics and other methods to identify important pathways and hub genes in ovarian cancer affected by WT1. The results showed that WT1 is highly expressed in ovarian cancer and is closely related to the overall survival and progression-free survival (PFS) of ovarian cancer. In ovarian cancer cell line SKOV3, WT1 downregulation increased the mRNA expression of 638 genes and decreased the mRNA
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Carlberg Rindestig, Frida, Marie Wiberg, John Eric Chaplin, Eva Henje, and Inga Dennhag. "Psychometrics of three Swedish physical pediatric item banks from the Patient-Reported Outcomes Measurement Information System (PROMIS)®: pain interference, fatigue, and physical activity." Journal of Patient-Reported Outcomes 5, no. 1 (2021). http://dx.doi.org/10.1186/s41687-021-00382-2.

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Abstract Background The Patient-Reported Outcomes Measurement Information System (PROMIS®) aims to provide self-reported item banks for several dimensions of physical, mental and social health. Here we investigate the psychometric properties of the Swedish pediatric versions of the Physical Health item banks for pain interference, fatigue and physical activity which can be used in school health care and other clinical pediatric settings. Physical health has been shown to be more important for teenagers’ well-being than ever because of the link to several somatic and mental conditions. The item
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Upegui-Arango, Luz Dary, Verena Mainz, Judith Gecht, et al. "Development of the German social attitude barriers and facilitators to participation-scales: an analysis according to the Rasch model." BMC Musculoskeletal Disorders 23, no. 1 (2022). http://dx.doi.org/10.1186/s12891-022-05339-0.

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Abstract Background Social attitudes experienced by people with disabilities can strongly impact upon their health and quality of life. The extent to which social attitude measurement transcends specific cultures is unknown. Thus, the aim of the study was to develop German item banks to assess social attitude barriers and facilitators to participation and compare the construct definition with that developed in the United States. Methods The American version of the two item banks assessing social attitudes that act as barriers and facilitators in persons with disabilities was translated into Ge
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28

Nazish Sana, Muhammad Shariq Shaikh, and Admin. "Sickle hemoglobin: How critical are laboratory quality measures for accurate identification?" Journal of the Pakistan Medical Association, January 12, 2021, 1–3. http://dx.doi.org/10.47391/jpma.533.

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Madam, Adult haemoglobin (Hb) comprises of 2 alpha and 2 beta-globin chains, each having a haem molecule attached. In healthy individuals, around 95-98% HbA (?2?2) and 2–3.5% of Hb A2 (?2?2) are present. The genetic defect of globin chain in which valine is replaced for glutamic acid at position 6 of ? globin chain results in sickle haemoglobin (HbS). Homozygous genetic defect (?S?S) results in a symptomatic disease called 'sickle cell anaemia' whereas, heterozygous (??S) state is asymptomatic and commonly called as "sickle cell trait' [1]. On deoxygenation and dehydration, HbS undergoes irrev
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Gibson, Prue. "Machinic Interagency and Co-evolution." M/C Journal 16, no. 6 (2013). http://dx.doi.org/10.5204/mcj.719.

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The ontological equality and material vitality of all things, and efforts to remove “the human” from its apical position in a hierarchy of being, are Object-Oriented Ontology theory (OOO) concepts. These axioms are useful in a discussion of the aesthetics of augmented robotic art, alongside speculations regarding any interagency between the human/non-human and possible co-evolutionary relationships. In addition, they help to wash out the sticky habits of conventional art writing, such as removed critique or an authoritative expert voice. This article aims to address the robotic work Accomplice
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Howell, Katherine. "The Suspicious Figure of the Female Forensic Pathologist Investigator in Crime Fiction." M/C Journal 15, no. 1 (2011). http://dx.doi.org/10.5204/mcj.454.

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Over the last two decades the female forensic pathologist investigator has become a prominent figure in crime fiction. Her presence causes suspicion on a number of levels in the narrative and this article will examine the reasons for that suspicion and the manner in which it is presented in two texts: Patricia Cornwell’s Postmortem and Tess Gerritsen’s The Sinner. Cornwell and Gerritsen are North American crime writers whose series of novels both feature female forensic pathologists who are deeply involved in homicide investigation. Cornwell’s protagonist is Dr Kay Scarpetta, then-Chief Medica
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