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Journal articles on the topic 'Diethylenetriaminepentaacetic acid (DTPA)'

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Published: 4 June 2021
Last updated: 20 February 2023

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1

Bonin, L., J. Aupiais, M. Kerbaa, P. Moisy, S. Topin, and B. Siberchicot. "Revisiting actinide–DTPA complexes in aqueous solution by CE-ICPMS and ab initio molecular dynamics." RSC Advances 6, no. 67 (2016): 62729–41. http://dx.doi.org/10.1039/c6ra08121e.

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Although thermodynamics of AnIVDTPA− (DTPA = diethylenetriaminepentaacetic acid) complexation have been reported for 50 years, reliable data at low ionic strength is still missing.
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2

Yao, Zhong Wei, Jun Xu, Da Wei Zhang, Hong Hui Lin, and Chuan Qin Xia. "DNA cleavage promoted by diethylenetriaminepentaacetic acid (DTPA) derivatives." Chinese Chemical Letters 20, no. 9 (September 2009): 1107–10. http://dx.doi.org/10.1016/j.cclet.2009.03.049.

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3

Li, Pingjing, Yayu Hong, Huatao Feng, and Sam F. Y. Li. "An efficient “off–on” carbon nanoparticle-based fluorescent sensor for recognition of chromium(vi) and ascorbic acid based on the inner filter effect." Journal of Materials Chemistry B 5, no. 16 (2017): 2979–88. http://dx.doi.org/10.1039/c7tb00017k.

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A simple approach based on calcination treatment of diethylenetriaminepentaacetic acid (DTPA) was developed to prepare water-soluble nitrogen doped carbon nanoparticles (N-CNPs) with a high quantum yield of approximately 53.7%.
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4

Stather, J. W., G. N. Stradling, S. A. Gray, J. Moody, and A. Hodgson. "Use of DTPA for Increasing the Rate of Elimination of Plutonium-238 and Americium-241 from Rodents after their Inhalation as the Nitrates." Human Toxicology 4, no. 6 (November 1985): 573–82. http://dx.doi.org/10.1177/096032718500400603.

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This study has shown that: 1 both inhaled (2 μmol/kg) and injected (30 μmol/kg) diethylenetriaminepentaacetic acid (DTPA) can reduce the lung deposit of 238Pu and 241 Am inhaled as nitrate to about 1% of that in untreated controls; 2 injection of DTPA is more effective than aerosolized DTPA for reducing deposits of 238 Pu and 241Am in the liver and skelton; 3 combined treatment involving early inhalation of DTPA followed by repeated intravenous injections is likely to be the most effective treatment for workers who have accidentally inhaled plutonium and americium nitrates.
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5

FUKUDA, Satoshi. "Assessment of toxicity on chelating agent DTPA(diethylenetriaminepentaacetic Acid)." Japanese Journal of Health Physics 24, no. 3 (1989): 201–10. http://dx.doi.org/10.5453/jhps.24.201.

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6

SATO, I., N. MATSUSAKA, H. KOBAYASHI, K. SERA, S. FUTATSUGAWA, and Y. NISHIMURA. "EFFECT OF Ca-DTPA ON ESSENTIAL TRACE METALS IN RATS." International Journal of PIXE 04, no. 01 (January 1994): 59–64. http://dx.doi.org/10.1142/s0129083594000088.

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Effects of one human-dose (30 µmol/kg) of calcium salt of diethylenetriaminepentaacetic acid (Ca-DTPA) on the urinary excretion of essential metals and on their concentration in several tissues were studied in rats by particle induced X-ray emission (PIXE). Ca-DTPA enhanced the urinary excretion of manganese, iron, copper and zinc, while their concentration in the liver, kidneys, brain and thigh bone remained unchanged. These results suggest that urinary loss of these metals caused by Ca-DTPA can be compensated by homeostatic mechanisms in the body under the treatment schedule of one human-dose per day.
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7

Vora, Manhar M. "HPLC analysis of indium-111 diethylenetriaminepentaacetic acid (111In-DTPA) radiopharmaceutical." International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes 42, no. 1 (January 1991): 19–24. http://dx.doi.org/10.1016/0883-2889(91)90119-l.

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8

Michalik, Katharina, Lukas Beyer, Florian Zeman, Christina Wendl, Janine Rennert, Claudia Fellner, Christian Stroszczynski, and Philipp Wiggermann. "Signal intensity in the dentate nucleus after cumulative dose of Gd-EOB-DTPA: First results of a prospective longitudinal study." Clinical Hemorheology and Microcirculation 76, no. 2 (October 30, 2020): 233–40. http://dx.doi.org/10.3233/ch-209219.

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Gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) is a hepatocyte-specific, linear ionic contrast agent for MRI. In comparison to other linear contrast agents Gd-EOB-DTPA is excreted equally through liver and kidneys. This prospective longitudinal study investigates the signal intensity (SI) in the dentate nucleus (DN) on unenhanced T1-weighted images after repetitive application of Gd-EOB-DTPA. 46 patients were included into the study and 107 MRI examinations were performed. Statistical analysis of 25 patients showed no significant correlation between cumulative dose of Gd-EOB-DTPA and SI change and between the DN/Pons ratiolast and the mean DN/Pons ratiofirst. Subgroup analysis however revealed a significant correlation for one out of two readers. Gd-EOB-DTPA deposition could not be proven in the framework of this study.
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9

Skuridin, Viktor S., Elena S. Stasyuk, and Vladimir I. Chernov. "Development of Magnetic-Resonance Contrast Composition Based on Disodium Salt of Gd-DTPA." Advanced Materials Research 1084 (January 2015): 549–53. http://dx.doi.org/10.4028/www.scientific.net/amr.1084.549.

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In this research we have studied contrast composition in the form of an aqueous solution containing gadolinium oxide (Gd2O3), diethylenetriaminepentaacetic acid (DTPA), medical polymer - polyvinylpyrrolidone mol. sq. (12000 ± 5000) daltons in an amount of 0.5-5 wt. %. To reduce the content of free gadolinium in the composition it has been suggested to change the stoichiometric ratio of the concentrations of DTPA/Gd2O3in the mixture. The studies have shown that at a concentration ratio of DTPA/Gd2O3, 2.07 - 2.10 the impurity content of free gadolinium is at least 0.25%, which is significantly below the regulated value - 0.5%. The conducted biomedical tests have confirmed the functionality of the resulting contrast composition.
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10

Smola, Sergiy, Natalya Rusakova, Elena Martsinko, Inna Seifullina, and Yuriy Korovin. "Spectroscopic Properties of the Ln-Ge Complexes with Diethylenetriaminepentaacetic Acid." Chemistry Journal of Moldova 2, no. 1 (December 2007): 83–87. http://dx.doi.org/10.19261/cjm.2007.02(1).10.

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Four new heteronuclear lanthanide complexes with general formula [Ge(OH)(μ-HDTPA)LnGe(OH) (μ-DTPA)] (Ln = Sm – Dy) were synthesized and subsequently characterized by different physico- chemical methods. The structures of new compounds have been proposed. In considered complexes the 4f-luminescence of three-charged ions of samarium, europium, terbium and dysprosium is realized at UV-excitation. It is noteworthy that it is the first observation of 4f-luminescence in water solutions of heteronuclear f-p-complexes. The comparison of luminescent characteristics of hetero- and homonuclear landthanide complexes is described and discussed as well.
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11

Yamazaki, E., S. Matsubara, and I. Yamada. "Effect of Gd-DTPA and/or Magnetic Field and Radiofrequency Exposure on Sister Chromatid Exchange in Human Peripheral Lymphocytes." Acta Radiologica 34, no. 6 (November 1993): 607–11. http://dx.doi.org/10.1177/028418519303400615.

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The effects of a magnetic field, radiofrequency, and gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) on the sister chromatid exchange (SCE) in human peripheral lymphocytes were investigated. Whole blood was taken from a nonsmoker and samples were exposed to magnetic force (1.5 T) alone, and to a magnetic force combined with radiofrequency waves (63.86 MHz, specific absorption rate, SAR, 0.4 W/kg). Gd-DTPA was then added to other blood samples in varying amounts and concentrations. After exposure to the conditions described above, these blood samples were cultured for 69 hours. Slides were made for an SCE evaluation. As the concentration of Gd-DTPA added to the blood increased, the SCE frequency also increased. However, the addition of Gd-DTPA at the clinical concentrations normally used did not affect the SCE frequency.
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12

Popov, Evgeny, Jussi Eloranta, Vesa Hietapelto, Veli-Matti Vuorenpalo, Reijo Aksela, and Jukka Jäkärä. "Mechanism of decomposition of peracetic acid by manganese ions and diethylenetriaminepentaacetic acid (DTPA)." Holzforschung 59, no. 5 (September 1, 2005): 507–13. http://dx.doi.org/10.1515/hf.2005.084.

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Abstract The decomposition mechanism of peracetic acid by free Mn2+ ions and by Mn2+-diethylenetriaminepentaacetic acid complexes was studied by UV/Vis, electrospray ionization-time of flight-mass spectrometry (ESI-TOF-MS), electron spin resonance (ESR), and Raman spectroscopy. The experimental results demonstrate that a number of different oxidation states of manganese are involved in the decomposition reaction. Furthermore, the kinetics observed show oscillatory features that are characteristic of autocatalytic processes. Radical pathways were found to play a negligible role in the reaction. Based on the experimental observations, an overall reaction scheme for the decomposition process is proposed.
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13

Peuralahti, Jari, Liisa Meriö, Veli-Matti Mukkala, Kaj Blomberg, and Jari Hovinen. "Synthesis and properties of a neutral derivative of diethylenetriaminepentaacetic acid (DTPA)." Bioorganic & Medicinal Chemistry Letters 16, no. 18 (September 2006): 4760–62. http://dx.doi.org/10.1016/j.bmcl.2006.06.088.

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14

Albano, Joseph P., and William B. Miller. "Iron Deficiency Stress Influences Physiology of Iron Acquisition in Marigold (Tagetes erecta L.)." Journal of the American Society for Horticultural Science 121, no. 3 (May 1996): 438–41. http://dx.doi.org/10.21273/jashs.121.3.438.

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Excised roots of `First Lady' marigold (Tagetes erecta L.) grown in an aerated 0 Fe nutrient solution had Fe(III)-DTPA reductase activity 14-fold greater, and an enhanced ability to acidify the rhizosphere than plants grown in a solution containing 0.018 mm (1 ppm) Fe-DTPA. Reductase activity and rhizosphere acidification of plants grown in 0.018 and 0.09 mm Fe-DTPA were similar. Manganese concentration in leaves of plants grown in the 0 Fe treatment was 2-fold greater than in leaves of plants grown in the 0.018 mm Fe-DTPA treatment. These results indicated that `First Lady' marigold is an Fe-efficient plant that possesses both an inducible or adaptive reductase system and the ability to acidify the rhizosphere, and that these Fe-efficiency reactions do not occur when Fe is sufficient. Chemical name used: ferric diethylenetriaminepentaacetic acid, monosodium salt (Fe-DTPA).
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15

Uehara, Hisao, Tadashi Miyagawa, Juri Tjuvajev, Revathi Joshi, Bradley Beattie, Takamitsu Oku, Ronald Finn, and Ronald Blasberg. "Imaging Experimental Brain Tumors with 1-Aminocyclopentane Carboxylic Acid and Alpha-Aminoisobutyric Acid: Comparison to Fluorodeoxyglucose and Diethylenetriaminepentaacetic Acid in Morphologically Defined Tumor Regions." Journal of Cerebral Blood Flow & Metabolism 17, no. 11 (November 1997): 1239–53. http://dx.doi.org/10.1097/00004647-199711000-00013.

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The goal of this study was to evaluate the differences and define the advantages of imaging experimental brain tumors in rats with two nonmetabolized amino acids, 1-aminocyclopentane carboxylic (ACPC) acid and α-aminoisobutyric (AIB) acid compared with imaging with fluorodeoxyglucose (FDG) or the gallium-diethylenetriaminepentaacetic acid chelate (Ga-DTPA). 1-aminocyclopentane carboxylic acid, AIB, and FDG autoradiograms were obtained 60 minutes after intravenous injection to simulate positron emission tomography (PET) imaging, whereas the Ga-DTPA autoradiograms were obtained 5 or 10 minutes after injection to simulate gadolinium (Gd)-DTPA–enhanced magnetic resonance (MR) images. Three experimental tumors were studied (C6, RG2, and Walker 256) to provide a range of tumor types. Triple-label quantitative autoradiography was performed, and parametric images of the apparent distribution volume (Va, mL/g) for ACPC or AIB, relative glucose metabolism (R, μmol/100 g/min), vascular permeability to Ga-DTPA (K1, μL/min/g), and histology were obtained from the same tissue section. The four images were registered in an image array processor, and regions of interest in tumor and contralateral brain were defined on morphologic criteria (histology) and were transferred to the autoradiographic images. A comparative analysis of all measured values was performed. The location and morphologic characteristics of the tumor had an effect on the images and measurements of Va, R, and K1. Meningeal extensions of all three tumors consistently had the highest amino acid uptake (Va) and vascular permeability (K1) values, and subcortical portions of the tumors usually had the lowest values. Va and R (FDG) values generally were higher in tumor regions with high-cell density and lower in regions with low-cell density. Tumor areas identified as “impending” necrosis on morphologic criteria consistently had high R values, but little or no change in Va or K1. Tumor necrosis was seen consistently only in the larger Walker 256 tumors; low values of R and Va for AIB (less for ACPC) were measured in the necrotic-appearing regions, whereas K1 was not different from the mean tumor value. The highest correlations were observed between vascular permeability (K1 for Ga-DTPA) and Va for AIB in all three tumors; little or no correlation between vascular permeability and R was observed. The advantages of ACPC and AIB imaging were most convincingly demonstrated in C6 gliomas and in Walker 256 tumors. 1-aminocyclopentane was substantially better than FDG or Ga-DTPA for identifying tumor infiltration of adjacent brain tissue beyond the macroscopic border of the tumor; ACPC also may be useful for identifying low-grade tumors with an intact blood–brain barrier. Contrast-enhancing regions of the tumors were visualized more clearly with AIB than with FDG or Ga-DTPA; viable and necrotic-appearing tumor regions could be distinguished more readily with AIB than with FDG. [11C]-labeled ACPC and AIB are likely to have similar advantages for imaging human brain tumors with PET.
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16

YG, Zhang, Zhang YY, Cai JP, P. Zhu, Gao HJ, and Y. Jiang. "Variation in available micronutrients in black soil after 30-year fertilization treatment." Plant, Soil and Environment 60, No. 9 (September 8, 2014): 387–93. http://dx.doi.org/10.17221/68/2014-pse.

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To assess the effects of long-term fertilization on soil available micronutrients in farmland, this study examined diethylenetriaminepentaacetic acid (DTPA) extractable iron (Fe), manganese (Mn), copper (Cu), and zinc (Zn) in surface soil with monoculture of corn (Zea mays L.) with a 30-year filed fertilization experiment established in Northeast China. Treatments included no fertilization (CK); nitrogen only (N); nitrogen and phosphorus only (NP); NP and potassium (NPK); NPK plus cornstalk (SNPK), and NPK plus farmyard manure (MNPK). Results showed that DTPA-Fe and Mn were significantly increased with chemical N application, and DTPA-Cu and Zn were significantly increased with farmyard manure amendment, while micronutrients were not significantly different between treatment SNPK and CK. DTPA-Fe and Mn were about twice to threefold in treatments N, NP, and NPK as much as in treatments SNPK, MNPK and CK. DTPA-Cu and Zn in treatment MNPK were about 3.9 and 6.5 times as much as in CK. DTPA-Fe and Mn decreased with the increasing of soil pH and cation exchange capacity, while DTPA-Cu and Zn increased with the increase of soil organic carbon and electrical conductivity.
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17

Safavy, Ahmad, Dale C. Smith,, Alireza Bazooband, and Donald J. Buchsbaum. "De Novo Synthesis of a New Diethylenetriaminepentaacetic Acid (DTPA) Bifunctional Chelating Agent." Bioconjugate Chemistry 13, no. 2 (March 2002): 317–26. http://dx.doi.org/10.1021/bc0100861.

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18

Bachman, Gary R., and Mary C. Halbrooks. "INFLUENCE OF IRON DTPA ON THE OCCURRENCE OF A SPECIFIC PHYSIOLOGICAL DISORDER IN CUTTING GERANIUM." HortScience 27, no. 11 (November 1992): 1166f—1166. http://dx.doi.org/10.21273/hortsci.27.11.1166f.

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The role of Fe DTPA (Diethylenetriaminepentaacetic acid) in the occurrence of a specific physiological disorder affecting the leaves of cutting geranium was investigated. Industry reports indicate that affected leaves have excessively high concentrations of Fe and sometimes Mn. Symptoms of the disorder first affect maturing leaves, and may in severe cases affect immature leaves. Symptoms progress from marginal/interveinal chlorosis and necrosis, to affect whole leaf necrosis. Rooted cuttings were grown in a soil-less peat based media, with Fe DTPA concentrations of 1, 5, 15, and 20 ppm. Iron and manganese leaf concentrations were significantly higher in symptom than in non-symptom tissue and increased as Fe DTPA treatment level increased. As Fe DTPA treatment level increased there was a significant increase in dry weight of symptom tissue and a decrease in non-symptom tissue dry weight. Plants grown in media amended with dolomite (pH> 5.8) had similar degrees of symptom occurrence compared to plants grown in unamended media (pH ≈ 5.4).
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19

Li, Kai, Long Zuo, Dong Qi He, and Hong Bin Han. "A Novel Parameter Estimation Method for Drug Diffusion, Distribution and Clearance in the Rat Brain Extracellular Space." Applied Mechanics and Materials 590 (June 2014): 805–13. http://dx.doi.org/10.4028/www.scientific.net/amm.590.805.

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Purposes to estimate parameters for gadolium-diethylenetriaminepentaacetic acid (Gd-DTPA) diffusion and distribution after drug delivery in the rat brain extracellular space (ECS). Methods An isotropic diffusion pattern in the homogeneous media was presumed for Gd-DTPA diffusion in the rat brain ECS, and a mathematical model was established to describe the pharmacokinetics of Gd-DTPA. Results the analytical solution of the diffusion equation was obtained by Laplace transform, and the least square method was utilized to calculate the diffusion coefficient (D) and the clearance rate (k) of drugs in the sphere coordinates. Animal experimental data of Gd-DTPA-related intensity was acquired by magnetic resonance imaging (MRI). D and k were computed as 0.0129 mm2/h and 0.0957 /h, respectively. Conclusions By the proposed method, drug diffusion, distribution, and clearance in the rat brain can be quantitatively analyzed, which will enhance our understanding of drug delivery in the central nervous system.
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20

HU, THOMAS Q., CARMEN MARGETTS, KRISTA MORROW, MICHELLE ZHAO, SURJIT JOHAL, and BERNARD YUEN. "Cost-effective brightening of thermomechanical pulp from mountain pine beetle-infested lodgepole pine." January 2011 10, no. 1 (February 1, 2011): 25–31. http://dx.doi.org/10.32964/tj10.1.25.

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We developed a cost-effective bleaching method for overcoming the brightness ceiling of thermomechanical pulp (TMP) made from mill chips containing predominantly mountain pine beetle-infested lodgepole pine. The method involves synergistic bleaching of the TMP in the refiner with hydrosulfite (Y) and diethylenetriaminepentaacetic acid (DTPA) as the chelating agent. The synergistic, in-refiner Y+DTPA bleaching, when followed by post-refiner Y or peroxide bleaching, can provide higher brightness gain or lower bleaching chemical cost for Y- or peroxide-bleached TMP from the mill chips. Estimated cost savings for Y bleaching to 60.0% ISO brightness and peroxide bleaching to 74.3% ISO brightness are USD 5.2/ton pulp and USD 5.2-6.2/ton pulp, respectively.
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21

Albano, Joseph P., William B. Miller, and Mary C. Halbrooks. "Iron Toxicity Stress Causes Bronze Speckle, a Specific Physiological Disorder of Marigold (Tagetes erecta L.)." Journal of the American Society for Horticultural Science 121, no. 3 (May 1996): 430–37. http://dx.doi.org/10.21273/jashs.121.3.430.

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A specific physiological disorder, bronze speckle (J.P.A.'s nomenclature), was consistently induced in `First Lady' and `Voyager' marigold with Fe-DTPA concentrations greater than 0.018 mm Fe-DTPA (1 ppm) applied to a soilless medium. The disorder was characterized by specific symptomology distinguished visually by speckled patterns of chlorosis and necrosis, and downward curling and cupping of leaves. The percentage of total leaf dry weight affected with symptoms generally increased with increasing Fe-DTPA treatments. Symptomatic leaf tissue had a greater Fe concentration than corresponding asymptomatic leaf tissue. Leaf Mn concentrations in symptomatic and asymptomatic tissue were similar. In `First Lady', older leaf tissue accumulated more total Fe and was associated with more severe symptoms than younger tissue. Media leachate Fe concentrations increased over 6 weeks and were larger at greater Fe-DTPA treatments. Adjustment of nutrient solution pH to 4.0, 5.25, or 6.5 did not alter media pH, nor did it prevent disorder symptoms. Application of Fe-DTPA containing nutrient solution to a soilless medium resulted in leachate Fe levels 3 times greater than for FeSO4 treatments. Chemical names used: ferric diethylenetriaminepentaacetic acid, monosodium salt (Fe-DTPA).
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22

Korkusuz, Huedayi, Karsten Ulbrich, Verena Bihrer, Katerina Welzel, Valery Chernikov, Thomas Knobloch, Sabine Petersen, et al. "Contrast Enhancement of the Brain by Folate-Conjugated Gadolinium–Diethylenetriaminepentaacetic Acid–Human Serum Albumin Nanoparticles by Magnetic Resonance Imaging." Molecular Imaging 11, no. 4 (July 1, 2012): 7290.2011.00047. http://dx.doi.org/10.2310/7290.2011.00047.

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Different from regular small molecule contrast agents, nanoparticle-based contrast agents have a longer circulation time and can be modified with ligands to confer tissue-specific contrasting properties. We evaluated the tissue distribution of polymeric nanoparticles (NPs) prepared from human serum albumin (HSA), loaded with gadolinium–diethylenetriaminepentaacetic acid (Gd-DTPA) (Gd-HSA-NP), and coated with folic acid (FA) (Gd-HSA-NP-FA) in mice by magnetic resonance imaging (MRI). FA increases the affinity of the Gd-HSA-NP to FA receptor–expressing cells. Clinical 3 T MRI was used to evaluate the signal intensities in the different organs of mice injected with Gd-DTPA, Gd-HSA-NP, or Gd-HSA-NP-FA. Signal intensities were measured and standardized by calculating the signal to noise ratios. In general, the NP-based contrast agents provided stronger contrasting than Gd-DTPA. Gd-HSA-NP-FA provided a significant contrast enhancement (CE) in the brain ( p = .0032), whereas Gd-DTPA or Gd-HSA-NP did not. All studied MRI contrast agents showed significant CE in the blood, kidney, and liver ( p < .05). Gd-HSA-NP-FA elicited significantly higher CE in the blood than Gd-HSA-NP ( p = .0069); Gd-HSA-NP and Gd-HSA-NP-FA did not show CE in skeletal muscle and gallbladder; Gd-HSA-NP, but not Gd-HSA-NP-FA, showed CE in the cardiac muscle. Gd-HSA-NP-FA has potential as an MRI contrast agent in the brain.
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23

Wikström, M., H. J. Martinussen, A. Ericsson, G. Wikström, A. Waldenström, and A. Hemmingsson. "Double-Contrast Enhanced Mr Imaging of Myocardial Infarction in the Pig." Acta Radiologica 34, no. 1 (January 1993): 64–71. http://dx.doi.org/10.1177/028418519303400114.

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Myocardial infarction was induced by ligating a diagonal branch of the left anterior descending artery in 18 pigs. All pigs were sacrificed 6 h after the occlusion. Dysprosium diethylenetriaminepentaacetic acid bismethylamide (Dy-DTPA-BMA, 1.0 mmol/kg) was administered i.v. to 6 pigs, starting 3 min before sacrifice (injection time approximately 1 min). In a second group of 6 pigs, a double-contrast technique was used, consisting of an i.v. injection of gadolinium-DTPA-BMA (0.4 mmol/kg) 2 h before sacrifice, followed by an i.v. injection of Dy-DTPA-BMA (1.0 mmol/kg) 3 min before sacrifice. Six additional pigs, subjected to 6 h of coronary artery occlusion without administration of contrast medium, served as controls. The hearts were excised and imaged with MR. In the control animals, the infarctions demonstrated an increased signal intensity in the proton density- and T2-weighted images. Administration of Dy-DTPA-BMA primarily improved infarct visualization in the proton density- and T2-weighted images, due to reduction of signal intensity in nonischemic myocardium. The double-contrast technique further improved infarct visualization in all sequences.
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24

De Stefano, Concetta, Antonio Gianguzza, Daniela Piazzese, and Silvio Sammartano. "Interactions of diethylenetriaminepentaacetic acid (dtpa) and triethylenetetraaminehexaacetic acid (ttha) with major components of natural waters." Analytical and Bioanalytical Chemistry 375, no. 7 (March 18, 2003): 956–67. http://dx.doi.org/10.1007/s00216-003-1790-8.

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25

Rupp, Larry A., and Lynn M. Dudley. "Iron Availability in Rockwool may Affect Rose Nutrition." HortScience 24, no. 2 (April 1989): 258–60. http://dx.doi.org/10.21273/hortsci.24.2.258.

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Abstract Rockwool is an inert medium for use in greenhouses. It is reported to contribute negligible nutrients to plants. However, Rosa multiflora ‘Burr’ rootstocks grown in Grodan rockwool exhibited no visible Fe chlorosis with an Fe-free nutrient solution. Leaf chlorophyll content was 2.65 mg·g-1 with Fe and 2.85 mg·g-1 without Fe. Available Fe concentrations of three commercial materials (Hortiwool, Grodan block, and Grodan loose), estimated by using diethylenetriaminepentaacetic acid (DTPA) extraction (2 DPTA : 1 rockwool, v/w), were 43.0, 0.33, and 3.95 mg Fe/liter, respectively. With long-term DTPA extractions (20:1), Fe extracted from Hortiwool and loose Grodan increased for ≈3 days before leveling off, while Fe extracted from Grodan block increased for 6 days. Measurable levels of Mn, Cu (348 mg·liter-1), and Zn were found in DTPA extracts of Hortiwool; measurable levels of Mn and Cu were extracted from loose Grodan and measurable levels only of Mn from Grodan block.
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26

Nirmaladevi, Muthulingam, Kumar Sanjiv Raj, and Vadakkeputhanmadom Krishnayer Subramanian. "Effect of Diethylenetriaminepentaacetic Acid (DTPA) on Crystal Growth and Morphology of Calcium Oxalate." Nephrology – Open Journal 3, no. 1 (December 28, 2017): 1–8. http://dx.doi.org/10.17140/npoj-3-116.

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27

Wu, Tinghuan, Lixian Sun, Fen Xu, and Dan Cai. "Nitrogen-doped hierarchical porous carbon materials derived from diethylenetriaminepentaacetic acid (DTPA) for supercapacitors." Journal of Materials Science & Technology 34, no. 12 (December 2018): 2384–91. http://dx.doi.org/10.1016/j.jmst.2018.06.005.

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28

Cousins, C., R. D. Gunasekera, M. Mubashar, S. Mohammadtaghi, R. Strong, M. J. Myers, and A. M. Peters. "Comparative Kinetics of Microvascular Inulin and 99mTc-Labelled Diethylenetriaminepenta-Acetic Acid Exchange." Clinical Science 93, no. 5 (November 1, 1997): 471–77. http://dx.doi.org/10.1042/cs0930471.

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1. After simultaneous intravenous injection as a mixture, 99mTc-labelled diethylenetriaminepentaacetic acid (99mTc-DTPA; molecular mass 492 Da) and inulin (∼6000 Da) gave arterial plasma clearance curves consisting of three exponentials, the time courses of which were not significantly different between the two solutes. 2. The ratio of 99mTc-DTPA to inuiin concentration in antecubital venous plasma (normalized to the ratio in arterial plasma at 30 s) was 0.6, significantly less than unity, within 2 min after intravenous injection, but increased to reach unity by 60 min. The minimun concentration ratio of 99mTc-DTPA to inulin in arterial plasma was 0.75 at 4 min, also rising to just above unity at 60 min. 3. The extraction fraction from plasma to interstitial space was higher for 99mTc-DTPA (∼0.5) than for inuiin (∼0.2). For both solutes, the net extraction fraction decreased with time, becoming negative at about 25 min after injection. Thereafter, the net extraction fractions remained negative, between −0.05 and −0.1, and not significantly different between the two solutes. 4. 99mTc-DTPA time—activity curves recorded over the limbs with scintillation probes were biphasic, with an initial phase corresponding closely in time with the first exponential of the arterial 99mTc-DTPA plasma clearance curve. The second phase corresponded in time to the intermediate exponential of the arterial 99mTc-DTPA plasma clearance curve. 5. The time course of net 99mTcm-DTPA extraction fraction across the forearm vascular bed was bi-exponential, with phases corresponding in time with the two phases of the limb uptake curves. 6. Deconvolution analysis of the limb time—activity curves, using the arterial time—concentration curve as the input function, gave bi-exponential 99mTc-DTPA impulse response curves in which the time courses of the exponentials corresponded with the first and intermediate exponentials of the arterial 99mTc-DTPA clearance curve. 7. The bi-exponential nature of the equilibrium of 99mTc-DTPA between vascular and interstitial compartments suggests the presence of two separate functional volumes within the interstitial space. Although 99mTc-DTPA and inuiin clearly diffuse at different rates across the endothelium, as would be expected from their disparate sizes, the similarity in the time courses of their initial exponentials and simultaneous equalization of transfer rates (i.e. when net extraction fraction was zero) is consistent with the hypothesis that inuiin moves initially into a smaller functional interstitial fluid volume than 99mTc-DTPA. The total distribution volumes, however, are not significantly different between the two solutes.
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Albuquerque, Isabella Martins de, Dannuey Machado Cardoso, Paulo Ricardo Masiero, Dulciane Nunes Paiva, Vanessa Regiane Resqueti, Guilherme Augusto de Freitas Fregonezi, and Sérgio Saldanha Menna-Barreto. "Effects of positive expiratory pressure on pulmonary clearance of aerosolized technetium-99m-labeled diethylenetriaminepentaacetic acid in healthy individuals." Jornal Brasileiro de Pneumologia 42, no. 6 (December 2016): 404–8. http://dx.doi.org/10.1590/s1806-37562015000000320.

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ABSTRACT Objective: To evaluate the effects of positive expiratory pressure (PEP) on pulmonary epithelial membrane permeability in healthy subjects. Methods: We evaluated a cohort of 30 healthy subjects (15 males and 15 females) with a mean age of 28.3 ± 5.4 years, a mean FEV1/FVC ratio of 0.89 ± 0.14, and a mean FEV1 of 98.5 ± 13.1% of predicted. Subjects underwent technetium-99m-labeled diethylenetriaminepentaacetic acid (99mTc-DTPA) radioaerosol inhalation lung scintigraphy in two stages: during spontaneous breathing; and while breathing through a PEP mask at one of three PEP levels-10 cmH2O (n = 10), 15 cmH2O (n = 10), and 20 cmH2O (n = 10). The 99mTc-DTPA was nebulized for 3 min, and its clearance was recorded by scintigraphy over a 30-min period during spontaneous breathing and over a 30-min period during breathing through a PEP mask. Results: The pulmonary clearance of 99mTc-DTPA was significantly shorter when PEP was applied-at 10 cmH2O (p = 0.044), 15 cmH2O (p = 0.044), and 20 cmH2O (p = 0.004)-in comparison with that observed during spontaneous breathing. Conclusions: Our findings indicate that PEP, at the levels tested, is able to induce an increase in pulmonary epithelial membrane permeability and lung volume in healthy subjects.
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30

Randt, C., R. Wittlinger, and W. Merz. "Analysis of nitrilotriacetic acid (NTA), ethylenediaminetetraacetic acid (EDTA) and diethylenetriaminepentaacetic acid (DTPA) in water, particularly waste water." Fresenius' Journal of Analytical Chemistry 346, no. 6-9 (1993): 728–31. http://dx.doi.org/10.1007/bf00321281.

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31

Brovč, Ema Valentina, Stane Pajk, Roman Šink, and Janez Mravljak. "Protein Formulations Containing Polysorbates: Are Metal Chelators Needed at All?" Antioxidants 9, no. 5 (May 20, 2020): 441. http://dx.doi.org/10.3390/antiox9050441.

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Proteins are prone to post-translational modifications at specific sites, which can affect their physicochemical properties, and consequently also their safety and efficacy. Sources of post-translational modifications include oxygen and reactive oxygen species. Additionally, catalytic amounts of Fe(II) or Cu(I) can promote increased activities of reactive oxygen species, and thus catalyse the production of particularly reactive hydroxyl radicals. When oxidative post-translational modifications are detected in the biopharmaceutical industry, it is common practice to add chelators to the formulation. However, the resultant complexes with metals can be even more damaging. Indeed, this is supported here using an ascorbate redox system assay and peptide mapping. Ethylenediaminetetraacetic acid (EDTA) addition strongly accelerated the formation of hydroxyl radicals in an iron-ascorbate system, while diethylenetriaminepentaacetic acid (DTPA) addition did not. When Fe(III) was substituted with Cu(II), EDTA addition almost stopped hydroxyl radical production, whereas DTPA addition showed continued production, but at a reduced rate. Further, EDTA accelerated metal-catalysed oxidation of proteins, and thus did not protect them from Fe-mediated oxidative damage. As every formulation is unique, justification for EDTA or DTPA addition should be based on experimental data and not common practice.
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Li, Ao, Dezhong Xu, Mengnan Zhang, Shengzhong Wu, Yu Li, Weisheng Sun, Yonghui Zhou, Omar Abo Madyan, Mizi Fan, and Jiuping Rao. "Grafting nanocellulose with diethylenetriaminepentaacetic acid and chitosan as additive for enhancing recycled OCC pulp fibres." Cellulose 29, no. 3 (January 10, 2022): 2017–32. http://dx.doi.org/10.1007/s10570-021-04390-9.

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AbstractThis paper develops a novel paper additive for effectively recycling old corrugated container (OCC) by functionalizing nanocellulose (NC) with diethylenetriaminepentaacetic acid (DTPA) and chitosan (CS), and investigate the reinforcing mechanisms and effect of the developed additive on the physical properties of recycled OCC pulp handsheets. The tensile, tear and burst index, air permeability, tensile energy absorption (TEA), and drainage performance of the recycled OCC handsheets are examined. Fourier transform infrared FTIR) spectroscopy, thermal gravimetric analysis (TGA) and scanning electron microscopy (SEM) are used for the chemical and microstructure characterization of both NC based additives and paper from recycled OCC pulp. The results show that functional groups on the NC based additive, such as carboxyl, amino and hydroxyl groups, can bond with the hydroxyl groups on the recycled OCC fibres to generate a chemical bond. This leads to an increase in the crosslinks and bonding area between the fibres, which increases their tensile strength and improves their recycling rate. SEM shows that the paper with NC based additives had tighter inter-fibre bonds and smaller paper pore structure. Addition of 0.3% NC-DTPA-CS additive results in optimal properties of the recycled OCC paper with an increase by 31.64%, 22.28% and 36.6% of tensile index, tear index, burst index respectively, and the air permeability decreases by 36.92%. Graphical Abstract
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33

Flamigni, F., G. Campana, L. Carboni, C. Guarnieri, and S. Spampinato. "Zinc is required for the expression of ornithine decarboxylase in a difluoromethylornithine-resistant cell line." Biochemical Journal 299, no. 2 (April 15, 1994): 515–19. http://dx.doi.org/10.1042/bj2990515.

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Dilution of quiescent L1210-DFMOr (difluoromethylornithine-resistant) cells in fresh medium containing serum led to the induction of ornithine decarboxylase (ODC) and to the expression of its mRNA, as determined by a sensitive solution-hybridization-RNase-protection assay. Addition of the chelating agent diethylenetriaminepentaacetic acid (DTPA) at seeding time caused an inhibition of the induction of ODC activity by up to 90%, and only Zn2+ of the bivalent metal ions tested was effective in reversing this effect. The inhibition of the induction of ODC activity was accompanied by a marked decrease, prevented by Zn2+ supplementation, of the accumulation of immunoreactive ODC protein and ODC mRNA. DTPA treatment also caused a slight acceleration of ODC turnover. These results indicate that a restricted Zn2+ availability in L1210-DFMOr cells impairs ODC induction remarkably, mainly by affecting the expression of the messenger.
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34

Khameneh, Elham Sattarzadeh, Mostafa M. Amini, Saeed Kakaei, and Alireza Khanchi. "Preparation of dual-modality yttrium-90 radiolabeled nanoparticles for therapeutic investigation." Radiochimica Acta 106, no. 11 (November 27, 2018): 897–907. http://dx.doi.org/10.1515/ract-2017-2901.

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Abstract Magnetic Fe3O4 nanoparticles with narrow size distribution were synthesized by simple and high yielded co-precipitation technique using ferrous salts with a molar ratio of Fe3+/Fe2+=2. After coating of the nanoparticles with Stöber silica (SiO2@Fe3O4), nanoparticles were functionalized by amine groups. Then chelator molecules diethylenetriaminepentaacetic (DTPA) and tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) were coupled to the APTS-SiO2@Fe3O4 to chelating Y-90 radiometal that makes these nanoparticles a suitable agent for therapeutic application as dual-modality PET/MRI imaging. The results show the coupling of DTPA takes place better than DOTA. Synthesis of magnetic nanoparticles (MNPs) was followed by structure identification using XRD, SEM, TGA and IR techniques. In order to trace MNPs biodistribution, the radiolabeled MNPs-DTPA were prepared using 90Y (production of 90Y/90Sr generator) with a good labeling efficiency (about 92%, RTLS method). The biodistribution of the radiolabeled MNPs was checked in normal male rats up to 24 h compared to free Y3+. The data shows that the tracer accumulation is in reticuloendothelial tissue while the stability of the complex is highly retained.
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35

Che Azimi, Abu Zar, Norhayati Abdullah, Fatmawati Adam, Zulkafli Hassan, Sunarti Abdul Rahman, and Mohd Zulhaizan Mohd Noor. "THE SIMULATION OF INTERMOLECULAR INTERACTIONS OF CARBOXYLIC AND AMINE GROUPS WITH CALCIUM CARBONATE." Jurnal Teknologi 85, no. 1 (December 2, 2022): 91–98. http://dx.doi.org/10.11113/jurnalteknologi.v85.18589.

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Surface facilities including tubing and valves at the oilfield have been plagued by mineral scale deposits, which are constitute of calcium carbonate (CaCO3). Penta-potassium diethylenetriaminepentaacetic acid salt (DTPA-K5) has a higher affinity for the metal cations complexes during the chelation process. The eight complexing sites (five carboxylate and three amines) empower the metal ion interactions. This work investigated the molecular dynamics simulations between the DTPA-K5 with the calcium carbonate, CaCO3 scale. The interaction was performed through molecular dynamic (MD) simulation using condensed phase optimised molecular potentials for atomistic simulation studies (COMPASS) force field and the Ewald summation method in Material Studio. The simulation trajectory files examined the intermolecular interactions for radial distribution function (RDF). The simulation shows strong DTPA-K5 with calcium interactions, which revealed the metal ion complexes contributing to the chelation process through the reactive carboxylic and amine functional groups, which were O7 == Ca at radius, r, 2.25 Å with g(r) of 10.09 and N1 -- Ca at radius, r, 2.25 Å with g(r) 2.51.
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Tamada, Tsutomu, Katsuyoshi Ito, Kazuya Yasokawa, Atsushi Higaki, Akihiko Kanki, Yasufumi Noda, and Akira Yamamoto. "Accumulation of Bile in the Gallbladder: Evaluation by means of Serial Dynamic Contrast-Enhanced Magnetic Resonance Cholangiography with Gadolinium Ethoxybenzyl Diethylenetriaminepentaacetic Acid." Gastroenterology Research and Practice 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/479067.

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The aim of this study was to evaluate the process of biliary excretion of gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) into the biliary tract and to assess the accumulation patterns in the gallbladder using MR cholangiography obtained with Gd-EOB-DTPA which is a liver-specific hepatobiliary contrast agent. Seventy-five patients underwent Gd-EOB-DTPA enhanced MR imaging. Serial multiphasic hepatobiliary phase imaging was qualitatively reviewed to evaluate the process of the biliary excretion of contrast agent into the bile duct and the gallbladder. The accumulation pattern of contrast agent into gallbladder was classified into two groups (group 1 = orthodromic type and group 2 = delayed type). Furthermore, the results in differences of the presence of T1 hyperintense bile or sludge of gallbladder, gall stones, wall thickening of gallbladder, chronic liver disease, and liver cirrhosis between two groups were compared. Forty-eight of 75 patients (64%) were included in group 1, and remaining 27 (36%) were in group 2. The frequency of the presence of T1 hyperintense bile or sludge of gallbladder was significantly higher in patients with group 2 than that in patients with group 1 (P=0.041). MR cholangiography obtained with Gd-EOB-DTPA showed that there may be an association between the biliary accumulation pattern in the gallbladder and the pathological condition.
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37

El-Din Mahmoud, Mohamed Ahmed. "Effect of Chlorite Clay-Mineral Dissolution on the Improved Oil Recovery From Sandstone Rocks During Diethylenetriaminepentaacetic Acid Chelating-Agent Flooding." SPE Journal 23, no. 05 (March 16, 2018): 1880–98. http://dx.doi.org/10.2118/189988-pa.

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Summary Sandstone oil reservoirs consist of different clay minerals, such as kaolinite, illite, and chlorite. While these clay minerals can highly affect oil recovery from sandstone oil reservoirs, no attention has been given to investigating the effects of clay minerals during such oil recovery, and no solution has been introduced to alleviate the effects. In this study, and for the first time, the effect of chlorite clay-mineral content on the improved oil recovery (IOR) from different sandstone rock samples was investigated. A new solution was proposed to eliminate the effect of chlorite on the oil recovery from sandstone rocks. Different sandstone cores were used, such as Berea (BSS), Bandera (BND), Kentucky (KSS), and Scioto (SCS) sandstone rocks with different clay minerals. ζ-potential measurements were used to investigate the surface charge of the different clays and different sandstone rocks with different fluids. Fluids such as seawater (SW), low-salinity water (LSW), fresh water, and chelating agents were used. Diethylenetriaminepentaacetic acid (DTPA) chelating agent was introduced to mitigate the chlorite effect on oil recovery from sandstone rocks. The wettability was evaluated using contact-angle measurements and the Amott test for different solutions and different rocks in the presence of actual crude oil. Coreflooding experiments were conducted using these fluids with different sandstone rocks to identify the effect of chlorite on the oil recovery. Coreflooding experiments showed that sandstone cores with high chlorite content yielded the lowest oil recovery when SW and LSW were used. The effect of chlorite on the oil recovery from the two sandstone rocks was minimized with 3 wt% DTPA chelating agent. More oil was recovered in the case of DTPA because of the iron chelation from chlorite. ζ-potential showed that sandstone with high chlorite content has a surface charge close to zero in the case of SW and fresh water. In addition, contact-angle measurements showed that samples with high chlorite content have less water-wetness, which will reduce oil recovery. Contact-angle measurements on chlorite sheets showed that chlorite is oil-wet compared with mica at the same conditions. The addition of high-pH DTPA chelating agent sequestered the iron from the chlorite clay minerals and changed the surface charge to very high negative value, and the contact angle confirmed that the rock changed to water-wet after adding the chelating agent. The Amott index showed that adding DTPA increased the water-wetness for SCS that contains 4 wt% chlorite.
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38

SUMITA, Yasutoyo, Tomio INOUE, Noboru ORIUCHI, Katsumi TOMIYOSHI, Yasuhito SASAKI, Toshio IIZUKA, Tadashi SUZUKI, and Hitoshi IGARASHI. "Evaluation of left ventricular function using 99mTc-diethylenetriaminepentaacetic acid-human serum albumin (DTPA-HSA)." RADIOISOTOPES 37, no. 9 (1988): 502–8. http://dx.doi.org/10.3769/radioisotopes.37.9_502.

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39

Lee, Ha Young, Hye Won Jee, Sung Mi Seo, Byung Kook Kwak, Gilson Khang, and Sun Hang Cho. "Diethylenetriaminepentaacetic Acid−Gadolinium (DTPA-Gd)-Conjugated Polysuccinimide Derivatives as Magnetic Resonance Imaging Contrast Agents." Bioconjugate Chemistry 17, no. 3 (May 2006): 700–706. http://dx.doi.org/10.1021/bc060014f.

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40

Soberanes, Yedith, Ana Gabriela Arvízu-Santamaría, Lorena Machi, Rosa Elena Navarro, and Motomichi Inoue. "Fluorescent aza-cyclophanes derived from diethylenetriaminepentaacetic acid (DTPA), and their complexation with Gd(III)." Polyhedron 35, no. 1 (March 2012): 130–36. http://dx.doi.org/10.1016/j.poly.2012.01.007.

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41

Reddy, Joseph D., Ronald R. Cobb, Nathanael W. Dungan, Laura L. Matthews, Kenneth V. Aiello, Gregg Ritter, Bärbel Eppler, et al. "Preclinical Toxicology, Pharmacology, and Efficacy of a Novel Orally Administered Diethylenetriaminepentaacetic acid (DTPA) Formulation." Drug Development Research 73, no. 5 (August 2012): 232–42. http://dx.doi.org/10.1002/ddr.21018.

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42

Vamvakidis, Kosmas, Theodora-Marianna Kostitsi, Antonis Makridis, and Catherine Dendrinou-Samara. "Diverse Surface Chemistry of Cobalt Ferrite Nanoparticles to Optimize Copper(II) Removal from Aqueous Media." Materials 13, no. 7 (March 27, 2020): 1537. http://dx.doi.org/10.3390/ma13071537.

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Water pollution by heavy metals is one of the most serious worldwide environmental issues. With a focus on copper(II) ions and copper complex removal, in the present study, ultra-small primary CoFe2O4 magnetic nanoparticles (MNPs) coated with octadecylamine (ODA) of adequate magnetization were solvothermally prepared. The surface modification of the initial MNPs was adapted via three different chemical approaches based on amine and/or carboxylate functional groups: (i) the deposition of polyethylimide (PEI), (ii) covalent binding with diethylenetriaminepentaacetic acid (DTPA), and (iii) conjugation with both PEI and DTPA, respectively. FT-IR, TGA, and DLS measurements confirmed that PEI or/and DTPA were successfully functionalized. The percentage of the free amine (−NH2) groups was also estimated. Increased magnetization values were found in case of PEI and DTPA-modified MNPs that stemmed from the adsorbed amine or oxygen ligands. Comparative UV–Vis studies for copper(II) ion removal from aqueous solutions were conducted, and the effect of time on the adsorption capacity was analyzed. The PEI-modified particles exhibited the highest adsorption capacity (164.2 mg/g) for copper(II) ions and followed the pseudo-second-order kinetics, while the polynuclear copper(II) complex Cux(DTPA)y was also able to be immobilized. The nanoadsorbents were quickly isolated from the solution by magnetic separation and regenerated easily by acidic treatment.
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43

Motaghian, H. R., and A. R. Hosseinpur. "  Copper release kinetics: Effect of two extractants and wheat (Triticum aestivum L.) rhizosphere." Plant, Soil and Environment 58, No. 10 (October 12, 2012): 471–76. http://dx.doi.org/10.17221/365/2012-pse.

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The greenhouse experiment was performed to determine Cu release characteristics in the bulk and the rhizosphere of some calcareous soils using rhizobox. The kinetics of Cu release in the bulk and the rhizosphere soils were determined by successive extraction with diethylenetriaminepentaacetic acid-triethanolamine (DTPA-TEA) and 10 mmol/L citric acid in a period of 1 to 504 h at 25 &plusmn; 1&deg;C. The results of kinetics study showed that Cu extracted using DTPA-TEA in the rhizosphere soils was significantly (P &lt; 0.01) lower than the bulk soils, while Cu extracted using citric acid in the rhizosphere soils was significantly (P &lt; 0.01) higher than the bulk soils. The mean of released Cu after 504 h using DTPA-TEA were 8.59 and 7.46 mg/kg in the bulk and the rhizosphere soils, respectively. The mean release of Cu after 504 h using citric acid was 14.73 and 16.05 mg/kg in the bulk and the rhizosphere soils, respectively. Release kinetics of Cu in two extractants conformed fairly well to parabolic diffusion, power function, and first order equations. The results of correlation analysis illustrated that a significant correlation between Cu desorption after 504 h with citric acid and Cu concentration in wheat was found (r = 0.96 and r = 0.90 in the rhizosphere and the bulk soils, respectively, P &lt; 0.01). Therefore, application of 10 mmol/L citric acid extractant would be recommended in the future study on the kinetics of release of Cu in calcareous soils. &nbsp;
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44

Miyagawa, Tadashi, Takamitsu Oku, Hisao Uehara, Revathi Desai, Bradley Beattie, Juri Tjuvajev, and Ronald Blasberg. "“Facilitated” Amino Acid Transport is Upregulated in Brain Tumors." Journal of Cerebral Blood Flow & Metabolism 18, no. 5 (May 1998): 500–509. http://dx.doi.org/10.1097/00004647-199805000-00005.

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The goal of this study was to determine the magnitude of “facilitated” amino acid transport across tumor and brain capillaries and to evaluate whether amino acid transporter expression is “upregulated” in tumor vessels compared to capillaries in contralateral brain tissue. Aminocyclopentane carboxylic acid (ACPC), a non-metabolized [14C]-labeled amino acid, and a reference molecule for passive vascular permeability, [67Ga]-gallium-diethylenetriaminepentaacetic acid (Ga-DTPA), were used in these studies. Two experimental rat gliomas were studied (C6 and RG2). Brain tissue was rapidly processed for double label quantitative autoradiography 10 minutes after intravenous injection of ACPC and Ga-DTPA. Parametric images of blood-to-brain transport (K1ACPC and K1Ga-DTPA, μL/min/g) produced from the autoradiograms and the histology were obtained from the same tissue section. These three images were registered in an image array processor; regions of interest in tumor and contralateral brain were defined on morphologic criteria (histology) and were transferred to the autoradiographic images to obtain mean values. The facilitated component of ACPC transport (∂KlACPC) was calculated from the K1ACPC and K1Ga-DTPA data, and paired comparisons between tumor and contralateral brain were performed. ACPC flux, K1ACPC, across normal brain capillaries (22.6 ± 8.1 μL/g/min) was >200-fold greater than that of Ga-DTPA (0.09 ± 0.04 μL/g/min), and this difference was largely (~90%) due to facilitated ACPC transport. Substantially higher K1ACPC values compared to corresponding K1DTPA values were also measured in C6 and RG2 gliomas. The ∂K1ACPC values for C6 glioma were more than twice that of contralateral brain cortex. K1ACPC and ∂K1ACPC values for RG2 gliomas was not significantly higher than that of contralateral cortex, although a ~2-fold difference in facilitated transport is obtained after normalization for differences in capillary surface area between RG2 tumors and contralateral cortex. K1ACPC, ∂K1ACPC, and K1DTPA were directly related to tumor cell density, were higher in regions of “impending” necrosis, and the tumor/contralateral brain ACPC radio-activity ratios (0 to 10 minutes) were very similar to that obtained with 0 to 60 minutes experiments. These results indicate that facilitated transport of ACPC is upregulated across C6 and RG2 glioma capillaries, and that tumors can induce upregulation of amino acid transporter expression in their supporting vasculature. They also suggest that early imaging (e.g., 0 to 20 minutes) with radiolabeled amino acids in a clinical setting may be optimal for defining brain tumors.
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45

Zhang, Anyun, Chenmei Mei, Yuezhou Wei, and Mikio Kumagai. "Preparation of a Novel Macroporous Silica-based Diglycolamide Derivative-impregnated Polymeric Composite and its Adsorption Mechanism for Rare Earth Metal Ions." Adsorption Science & Technology 25, no. 5 (June 2007): 257–72. http://dx.doi.org/10.1260/026361707783432579.

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Diethylenetriaminepentaacetic acid (DTPA), a multi-dentate acidic chelating agent containing five carboxyl and three amine groups all capable of protonation, is a pentabasic acid. To separate minor actinide [MA(III)] and rare earth [RE(III)] elements effectively from a HNO3 solution containing DTPA generated in the MAREC process, a functional polymeric composite impregnated with a novel macroporous silica-based diglycolamide compound, N,N,N′,N′-tetraoctyl-3-oxapentane-1,5-diamide (TODGA), was prepared. Thus, the impregnated functional polymeric composite (TODGA/SiO2-P) was obtained by impregnating and immobilizing TODGA molecules in the pores of the SiO2-polymer (SiO2-P) particles (ca. 50 μm diameter) via a vacuum sucking technique. The effects of H+ ions within the concentration range 0.01–3.0 M and of NO3− ions within the range 0.1–3.115 M on the adsorption of RE(III) ions onto TODGA/SiO2-P were investigated at 298 K. It was found that in the presence of 0.05 M DTPA, the DTPA species strongly affected the adsorption of RE(III) ions. The adsorption capability of TODGA/SiO2-P depended on the competitive reactions of RE(III) ions with two species, viz. H4DTPA− and H2DTPA3−. The distribution coefficient (Kd) for RE(III) ions increased with increasing NO3− concentration, with one RE(III) ion reacting with two NO3− ions. The adsorption mechanism of RE(III) ions towards the TODGA/SiO2-P polymeric composite in HNO3 solution containing 0.05 M DTPA was suggested as: [Formula: see text] The formation of H4DTPA− and RE(H4DTPA)(NO3)2 which are both capable of adsorbing with TODGA/SiO2-P was the main reason why RE(III) ions exhibited such significant adsorption in the presence of 0.05 M DTPA.
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46

Takeda, Nobutaka, Atsunori Tsuchiya, Kazuki Natsui, Yui Ishii, Yoshihisa Arao, Naruhiro Kimura, Kentaro Tominaga, et al. "Novel Strategy for Diagnosis of Focal Nodular Hyperplasia Using Gadolinium Ethoxybenzyl Diethylenetriaminepentaacetic Acid: Enhanced Magnetic Resonance Imaging and Magnetic Resonance Elastography." Case Reports in Gastroenterology 15, no. 2 (June 10, 2021): 507–12. http://dx.doi.org/10.1159/000516552.

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Focal nodular hyperplasia (FNH) is the second most frequent benign liver tumor, and it is a fiber-rich stiff lesion. Typically, FNH can be diagnosed by imaging without biopsy. However, liver biopsy and diagnostic resection may be required to differentiate atypical FNH from other liver tumors, such as hepatocellular adenoma (HCA). Therefore, improved noninvasive diagnostic methods are needed. We experienced 2 cases where combination of magnetic resonance elastography (MRE) and gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) helped diagnose FNH. A 36-year-old woman and 17-year-old boy with liver tumors measuring 40 mm in diameter each showed hypointense nodule centers, indicating a central scar, surrounded by hyperintense signals during the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI. To rule out HCA, we performed MRE and liver biopsy. On MRE, the mean stiffness of the mass was 11.6 kPa (mean stiffness of the background liver was 1.7 kPa) and 11.1 kPa (mean stiffness of the background liver was 2.4 kPa) in the first and second patients, respectively. Histological examination of both specimens showed CK7-positive bile-ductular proliferations, abundant fibrous tissue, and few Ki-67-positive cells. Based on these results, we diagnosed these tumors as FNH. Combination of Gd-EOB-DTPA-enhanced MRI and MRE can evaluate the character and stiffness of lesion and help in the diagnosis of FNH.
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47

Nolop, K. B., D. L. Maxwell, D. Royston, and J. M. Hughes. "Effect of raised thoracic pressure and volume on 99mTc-DTPA clearance in humans." Journal of Applied Physiology 60, no. 5 (May 1, 1986): 1493–97. http://dx.doi.org/10.1152/jappl.1986.60.5.1493.

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Although positive airway pressure is often used to treat acute pulmonary edema, the effects on epithelial solute flux are not well known. We measured independently the effect of 1) positive pressure and 2) voluntary hyperinflation on the clearance of inhaled technetium-99m-labeled diethylenetriaminepentaacetic acid (99mTc-DTPA) in six nonsmokers and six smokers. Lung volumes were monitored by inductance plethysmography. Each subject was studied in four situations: 1) low end-expiratory volume (LO-), 2) low volume plus 9 cmH2O continuous positive airway pressure (LO+), 3) high end-expiratory volume (HI-), and 4) high volume plus continuous positive airway pressure (HI+). The clearance half time of 99mTc-DTPA for the nonsmokers decreased from 64.8 +/- 7.0 min (mean +/- SE) at LO- to 23.2 +/- 5.3 min at HI- (P less than 0.05). Positive pressure had no synergistic effect. The mean clearance half time for the smokers was faster than nonsmokers at base line but unaffected by similar changes in thoracic volume and pressure. We conclude that, in nonsmokers, positive airway pressure increases 99mTc-DTPA clearance primarily through an increase in lung volume and that smokers are immune to these effects.
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48

Pou, N. A., R. J. Roselli, R. E. Parker, J. A. Clanton, and T. R. Harris. "Measurement of lung fluid volumes and albumin exclusion in sheep." Journal of Applied Physiology 67, no. 4 (October 1, 1989): 1323–30. http://dx.doi.org/10.1152/jappl.1989.67.4.1323.

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A radioactive tracer technique was used to determine interstitial diethylenetriaminepentaacetic acid (DTPA) and albumin distribution volume in sheep lungs. 125I- and/or 131I-labeled albumin were injected intravenously and allowed to equilibrate for 24 h. 99mTc-labeled DTPA and 51Cr-labeled erythrocytes were injected and allowed to equilibrate (2 h and 15 min, respectively) before a lethal dose of thiamylal sodium. Two biopsies (1–3 g) were taken from each lung and the remaining tissue was homogenized for wet-to-dry lung weight and volume calculations. Estimates of distribution volumes from whole lung homogenized samples were statistically smaller than biopsy samples for extravascular water, interstitial 99mTc-DTPA, and interstitial albumin. The mean fraction of the interstitium (Fe), which excludes albumin, was 0.68 +/- 0.04 for whole lung samples compared with 0.62 +/- 0.03 for biopsy samples. Hematocrit may explain the consistent difference. To make the Fe for biopsy samples match that for homogenized samples, a mean hematocrit, which was 82% of large vessel hematocrit, was required. Excluded volume fraction for exogenous sheep albumin was compared with that of exogenous human albumin in two sheep, and no difference was found at 24 h.
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49

Albano, Joseph P., and William B. Miller. "Marigold Cultivars Vary in Susceptibility to Iron Toxicity." HortScience 33, no. 7 (December 1998): 1180–82. http://dx.doi.org/10.21273/hortsci.33.7.1180.

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The susceptibility of seven African marigold (Tagetes erecta L.) cultivars to iron toxicity was assessed. Plants were grown in a greenhouse in a soilless medium and Fe-DTPA was incorporated into the nutrient solution at either 0.018 mmol·L-1 (low) or 0.36 mmol·L-1 (high). Symptoms of Fe toxicity (bronze speckle disorder in marigold characterized by chlorotic and necrotic speckling and downward leaf cupping and curling) developed only in the high-Fe treatment. The concentration of Fe in leaves in the high-Fe treatment was 5.6 and 1.7 times as great as in the low-Fe treatment for `Orange Jubilee' and `Discovery Orange', respectively. Based upon the percentage of plants affected and leaf symptom severity, relative cultivar susceptibility to Fe toxicity was Orange Jubilee > First Lady > Orange Lady > Yellow Galore > Gold Lady > Marvel Gold > Discovery Orange. Chemical names used: ferric diethylenetriaminepentaacetic acid, disodium salt dihydrate (Fe-DTPA).
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50

Rusakova, Natalya, Nikolay Semenishyn, and Yuriy Korovin. "Heteronuclear lanthanide-containing complexes on the base of modified porphyrins and their luminescent properties." Journal of Porphyrins and Phthalocyanines 14, no. 02 (February 2010): 166–69. http://dx.doi.org/10.1142/s1088424610001817.

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The mono- and heteronuclear complexes of the general formula M-ATPP-Ln-L ( Ln = Yb , Lu; M = Zn , Cu , 2H ; ATPP - mono-p-aminotetraphenylporphyrin; L = EDTA - ethylenediaminetetraacetic acid or DTPA - diethylenetriaminepentaacetic acid) were prepared and characterized by elemental analysis, MS, 1H NMR, UV-vis and luminescent spectra. In all compounds the lanthanide ion is coordinated by aminopolycarboxylic fragment only. The spectra of metal complexes were compared with those of free-base porphyrins. Luminescence studies showed that porphyrin fragment of ligands absorbed the visible light and transferred the energy to lanthanide (ytterbium) ion emitting in the near IR-region. Efficiency of the 4f-luminescence has been determined for d-f-metal containing porphyrin complexes in comparison with the mononuclear Yb-containing complexes in DMF solutions.
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