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Journal articles on the topic 'Dietetics and Nutrigenomics'

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Author: Grafiati

Published: 10 December 2022

Last updated: 28 January 2023

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1

German, J. Bruce. "Genetic dietetics: Nutrigenomics and the future of dietetics practice." Journal of the American Dietetic Association 105, no. 4 (April 2005): 530–31. http://dx.doi.org/10.1016/j.jada.2005.02.034.

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2

Labadarios, Demetre, and Michael M. Meguid. "Nutrigenomics:." Nutrition 20, no. 1 (January 2004): 2–3. http://dx.doi.org/10.1016/j.nut.2003.10.017.

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3

Trujillo, Elaine, Cindy Davis, and John Milner. "Nutrigenomics, Proteomics, Metabolomics, and the Practice of Dietetics." Journal of the American Dietetic Association 106, no. 3 (March 2006): 403–13. http://dx.doi.org/10.1016/j.jada.2005.12.002.

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4

Ferguson, Lynnette, and Matthew Barnett. "Nutrigenomics and Nutrigenetics Research in New Zealand, and Its Relevance and Application to Gastrointestinal Health." Nutrients 14, no. 9 (April 22, 2022): 1743. http://dx.doi.org/10.3390/nu14091743.

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Nutrigenomics New Zealand (NuNZ) was a collaborative research programme built among three organisations—the University of Auckland, AgResearch Limited and Plant & Food Research. The programme ran for ten years, between 2004 and 2014, and was tasked with developing the then emerging field of nutrigenomics, investigating its applications to New Zealand, and potential benefits to the plant food and agricultural sectors. Since the beginning of the programme, nutrigenomics was divided into two fields—nutrigenetics and nutrigenomics. The first of these is now more commonly called personalised nutrition, and has recently been recognised and criticised by elements of the dietetics and management sector in New Zealand, who currently do not appear to fully appreciate the evolving nature of the field, and the differing validity of various companies offering the tests that form the basis of this personalisation. Various science laboratories are utilising “omics” sciences, including transcriptomics, metabolomics, proteomics and the comprehensive analysis of microbial communities such as the gut microbiota, in order to understand the mechanisms by which certain food products and/or diets relevant to New Zealand, confer a health benefit, and the nature of potential health claims that may be made on the basis of this information. In this article, we give a brief overview of the nutrigenomics landscape in New Zealand since the end of the NuNZ programme, with a particular focus on gastrointestinal health.

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5

Dhanapal, Anto Cordelia T. A., Ramatu Wuni, Eduard F. Ventura, Teh Kuan Chiet, Eddy S. G. Cheah, Annaletchumy Loganathan, Phoon Lee Quen, et al. "Implementation of Nutrigenetics and Nutrigenomics Research and Training Activities for Developing Precision Nutrition Strategies in Malaysia." Nutrients 14, no. 23 (December 1, 2022): 5108. http://dx.doi.org/10.3390/nu14235108.

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Nutritional epidemiological studies show a triple burden of malnutrition with disparate prevalence across the coexisting ethnicities in Malaysia. To tackle malnutrition and related conditions in Malaysia, research in the new and evolving field of nutrigenetics and nutrigenomics is essential. As part of the Gene-Nutrient Interactions (GeNuIne) Collaboration, the Nutrigenetics and Nutrigenomics Research and Training Unit (N2RTU) aims to solve the malnutrition paradox. This review discusses and presents a conceptual framework that shows the pathway to implementing and strengthening precision nutrition strategies in Malaysia. The framework is divided into: (1) Research and (2) Training and Resource Development. The first arm collects data from genetics, genomics, transcriptomics, metabolomics, gut microbiome, and phenotypic and lifestyle factors to conduct nutrigenetic, nutrigenomic, and nutri-epigenetic studies. The second arm is focused on training and resource development to improve the capacity of the stakeholders (academia, healthcare professionals, policymakers, and the food industry) to utilise the findings generated by research in their respective fields. Finally, the N2RTU framework foresees its applications in artificial intelligence and the implementation of precision nutrition through the action of stakeholders.

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6

Mortensen, Alicja, Ilona K. Sorensen, Colin Wilde, Stefania Dragoni, Dana Mullerová, Olivier Toussaint, Zdeněk Zloch, Giampietro Sgaragli, and Jaroslava Ovesná. "Biological models for phytochemical research: from cell to human organism." British Journal of Nutrition 99, E-S1 (May 2008): ES118—ES126. http://dx.doi.org/10.1017/s0007114508965806.

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Nutrigenomics represents a shift of nutrition research from epidemiology and physiology to molecular biology and genetics. Nutrigenomics seeks to understand nutrition influences on homeostasis, the mechanism of genetic predispositions for diseases, to identify the genes influencing risk of diet related diseases. This review presents some in vitro models applicable in nutrigenomic studies, and discuses the use of animal models, their advantages and limitations and relevance for human situation. In vitro and in vivo models are suitable for performance of DNA microarrays, proteomic and transcriptomic analyses. In vitro models (intracellular organelles and suborganellar compartments, cell cultures, or tissue samples/cultures) give insight in metabolic pathways and responses to test stimuli on cellular and molecular levels. Animal models allow evaluation of the biological significance of the effects recorded in vitro and testing of the hypothesis on how a specific factor affects specific species under specific circumstances. Therefore, the evaluation of the data in relation to human organism should be done carefully, considering the species differences. The use of in vitro and in vivo models is likely to continue as the effects of nutrition on health and disease cannot be fully explained without understanding of nutrients action at nuclear level and their role in the intra- and intercellular signal transduction. Through advances in cell and molecular biology (including genomic and proteomic), the use of these models should become more predictively accurate. However, this predictive value relies on an underpinning knowledge of the advantages and limitations of the model in nutrigenomic research as in other fields of biomedical research.

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7

Gomase, V. S., and S. Tagore. "Nutrigenomics." International Journal of Food Safety, Nutrition and Public Health 2, no. 1 (2009): 89. http://dx.doi.org/10.1504/ijfsnph.2009.026922.

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8

Trayhurn, Paul. "Nutritional genomics – “Nutrigenomics”." British Journal of Nutrition 89, no. 1 (January 2003): 1–2. http://dx.doi.org/10.1079/bjn2002780.

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9

Cade, Janet. "Nutrigenetics and Nutrigenomics." Journal of Human Nutrition and Dietetics 18, no. 5 (October 2005): 401. http://dx.doi.org/10.1111/j.1365-277x.2005.00638.x.

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10

Komduur, Rixt H., Michiel Korthals, and Hedwig te Molder. "The good life: living for health and a life without risks? On a prominent script of nutrigenomics." British Journal of Nutrition 101, no. 3 (October 2, 2008): 307–16. http://dx.doi.org/10.1017/s0007114508076253.

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Like all scientific innovations, nutrigenomics develops through a constant interplay with society. Normative assumptions, embedded in the way researchers formulate strands of nutrigenomics research, affect this interplay. These assumptions may influence norms and values on food and health in our society. To discuss the possible pros and cons of a society with nutrigenomics, we need to reflect ethically on assumptions rooted in nutrigenomics research. To begin with, we analysed a set of scientific journal articles and explicated three normative assumptions embedded in the present nutrigenomics research. First, values regarding food are exclusively explained in terms of disease prevention. Health is therefore a state preceding a sum of possible diseases. Second, it is assumed that health should be explained as an interaction between food and genes. Health is minimised to quantifiable health risks and disease prevention through food–gene interactions. The third assumption is that disease prevention by minimisation of risks is in the hands of the individual and that personal risks, revealed either through tests or belonging to a risk group, will play a large role in disease prevention. Together, these assumptions suggest that the good life (a life worth living, with the means to flourish and thrive) is equated with a healthy life. Our thesis is that these three normative assumptions of nutrigenomics may strengthen the concerns related to healthism, health anxiety, time frames and individual responsibilities for health. We reflect on these ethical issues by confronting them in a thought experiment with alternative, philosophical, views of the good life.

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11

Hendriks, Henk F. J. "Use of nutrigenomics endpoints in dietary interventions." Proceedings of the Nutrition Society 72, no. 3 (May 28, 2013): 348–51. http://dx.doi.org/10.1017/s0029665113001304.

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In this paper, the nutrigenomics approach is discussed as a research tool to study the physiological effects of nutrition and consequently how nutrition affects health and disease (endpoints). Nutrigenomics is the study of the effects of foods and food constituents on gene expression; the analyses include analysis of mRNA, proteins and metabolites. Nutrigenomics may be useful in dealing with the challenges that nutrition research is facing; by integrating the description of numerous active genes and metabolic pathways stronger evidence and new biomarkers for subtle nutritional effects may be obtained. Also, a new definition of disease and health may be needed. The use of tests challenging homoeostasis is being proposed to help define health. Challenge tests may be able to demonstrate in a better way subtle beneficial effects of nutrition on health. The paper describes some basic concepts relevant to nutrition research as well as some of the possibilities that are offered by nutrigenomics technology. Some of its applications are described.

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12

Bergmann, Manuela M., Ulf Görman, and John C. Mathers. "Bioethical Considerations for Human Nutrigenomics." Annual Review of Nutrition 28, no. 1 (August 2008): 447–67. http://dx.doi.org/10.1146/annurev.nutr.28.061807.155344.

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13

Chadwick, Ruth. "Nutrigenomics, individualism and public health." Proceedings of the Nutrition Society 63, no. 1 (February 2004): 161–66. http://dx.doi.org/10.1079/pns2003329.

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Issues arising in connection with genes and nutrition policy include both nutrigenomics and nutrigenetics. Nutrigenomics considers the relationship between specifc nutrients or diet and gene expression and, it is envisaged, will facilitate prevention of diet-related common diseases. Nutrigenetics is concerned with the effects of individual genetic variation (single nucleotide polymorphisms) on response to diet, and in the longer term may lead to personalised dietary recommendations. It is important also to consider the surrounding context of other issues such as novel and functional foods in so far as they are related to genetic modification. Ethical issues fall into a number of categories: (1) why nutrigenomics? Will it have important public health benefits? (2) questions about research, e.g. concerning the acquisition of information about individual genetic variation; (3) questions about who has access to this information, and its possible misuse; (4) the applications of this information in terms of public health policy, and the negotiation of the potential tension between the interests of the individual in relation to, for example, prevention of conditions such as obesity and allergy; (5) the appropriate ethical approach to the issues, e.g. the moral difference, if any, between therapy and enhancement in relation to individualised diets; whether the 'technological fix' is always appropriate, especially in the wider context of the purported lack of public confidence in science, which has special resonance in the sphere of nutrition.

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14

Saito, Kenji, Soichi Arai, and Hisanori Kato. "A nutrigenomics database – integrated repository for publications and associated microarray data in nutrigenomics research." British Journal of Nutrition 94, no. 4 (October 2005): 493–95. http://dx.doi.org/10.1079/bjn20051536.

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In the current situation where microarray data in the field of nutritional genomics (nutrigenomics) are accumulating rapidly, there is imminent need for an efficient data infrastructure to support research workflow. We have established a web-based, integrated database of the publications and microarray expression data in the field of nutrigenomics. The registered data include links to external databases such as PubMed of the National Center for Biotechnology Information and public microarray databases that contain Minimum Information About a Microarray Experiment-compliant microarray expression data. Using this database, all data sets created will be effectively utilized and shared with other researchers. This database is built on an open-source database system and is freely accessible via the World Wide Web (http://a-yo5.ch.a.u-tokyo.ac.jp/index.phtml</url).

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15

Ordovas, Jose M., and Vincent Mooser. "Nutrigenomics and nutrigenetics." Current Opinion in Lipidology 15, no. 2 (April 2004): 101–8. http://dx.doi.org/10.1097/00041433-200404000-00002.

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16

Evans, David A., Julie B. Hirsch, and Slavik Dushenkov. "Phenolics, inflammation and nutrigenomics." Journal of the Science of Food and Agriculture 86, no. 15 (2006): 2503–9. http://dx.doi.org/10.1002/jsfa.2702.

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17

Arab, Lenore. "Individualized nutritional recommendations: do we have the measurements needed to assess risk and make dietary recommendations?" Proceedings of the Nutrition Society 63, no. 1 (February 2004): 167–72. http://dx.doi.org/10.1079/pns2003325.

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Is the information currently available to adjust nutritional recommendations and develop individualized nutrition? No. There is not even the information needed for setting dietary recommendations with confidence now at the group level. Will it be available soon? The answer to this question depends on the drive and will of the nutritional community, the success in recruiting funding to the area, the education of nutritionists and the spawning of great ideas and approaches. The emerging tools of genomics, proteomics and metabolomics are enabling the in-depth study of relationships between diet, genetics and metabolism. The advent of technologies can be compared with the discovery of the microscope and the new dimensions of scientific visualization enabled by that discovery. Nutritionists stand at the crest of new waves of data that can be generated, and new methods for their digestion will be required. To date, the study of dietary requirements has been based largely on a black box approach. Subjects are supplemented or depleted and clinical outcomes are observed. Few recommendations are based on metabolic outcomes. Metabolomics and nutrigenomics promise tools with which recommendations can be refined to meet individual requirements and the potential of individualized nutrition can be explored. As yet, these tools are not being widely applied in nutritional research and are rarely being applied by nutritionists. The result is often interesting research that is frequently nutritionally flawed, resulting in inappropriate conclusions. Nutritional education is needed to put nutritionists at the forefront of the development of applications for these technologies, creating a generation of nutrigenomicists. A new generation of nutritionists should be working interdisciplinarily with geneticists, molecular biologists and bioinformaticians in the development of research strategies. The present paper reviews the current status of nutrigenomic research, the current controversies and limitations, and developments needed to advance nutrigenomics and explore fully the promise of individualized nutritional recommendations.

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18

Nichols, John. "The Second International Nutrigenomics Conference: From Nutrigenomics to Nutritional Systems Biology." Journal of Nutritional & Environmental Medicine 14, no. 4 (December 2004): 331–32. http://dx.doi.org/10.1080/13590840500088503.

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19

Kaput, Jim, Jose M. Ordovas, Lynnette Ferguson, Ben van Ommen, Raymond L. Rodriguez, Lindsay Allen, Bruce N. Ames, et al. "The case for strategic international alliances to harness nutritional genomics for public and personal health." British Journal of Nutrition 94, no. 5 (November 2005): 623–32. http://dx.doi.org/10.1079/bjn20051585.

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Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene–nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient–genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countries.

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20

Penders, Bart, Rein Vos, and Klasien Horstman. "Side effects of problem-solving strategies in large-scale nutrition science: towards a diversification of health." British Journal of Nutrition 102, no. 10 (June 17, 2009): 1400–1403. http://dx.doi.org/10.1017/s0007114509990651.

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Solving complex problems in large-scale research programmes requires cooperation and division of labour. Simultaneously, large-scale problem solving also gives rise to unintended side effects. Based upon 5 years of researching two large-scale nutrigenomic research programmes, we argue that problems are fragmented in order to be solved. These sub-problems are given priority for practical reasons and in the process of solving them, various changes are introduced in each sub-problem. Combined with additional diversity as a result of interdisciplinarity, this makes reassembling the original and overall goal of the research programme less likely. In the case of nutrigenomics and health, this produces a diversification of health. As a result, the public health goal of contemporary nutrition science is not reached in the large-scale research programmes we studied. Large-scale research programmes are very successful in producing scientific publications and new knowledge; however, in reaching their political goals they often are less successful.

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21

Ghosh, D., M. A. Skinner, and W. A. Laing. "Pharmacogenomics and nutrigenomics: synergies and differences." European Journal of Clinical Nutrition 61, no. 5 (January 10, 2007): 567–74. http://dx.doi.org/10.1038/sj.ejcn.1602590.

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22

Gillies, Peter J. "Nutrigenomics: the Rubicon of molecular nutrition." Journal of the American Dietetic Association 103, no. 12 (December 2003): 50–55. http://dx.doi.org/10.1016/j.jada.2003.09.037.

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23

Korthals, Michiel. "Coevolution of nutrigenomics and society: ethical considerations." American Journal of Clinical Nutrition 94, suppl_6 (November 2, 2011): 2025S—2029S. http://dx.doi.org/10.3945/ajcn.110.001289.

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24

Simopoulos, Artemis P. "Genetic variation and dietary response: Nutrigenetics/nutrigenomics." Asia Pacific Journal of Clinical Nutrition 11 (September 26, 2002): S117—S128. http://dx.doi.org/10.1046/j.1440-6047.11.s6.3.x.

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25

Van Horn, Linda. "March Marks Finale in DeBusk Nutrigenomics Series." Journal of the American Dietetic Association 109, no. 3 (March 2009): 381. http://dx.doi.org/10.1016/j.jada.2009.01.001.

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26

Cormier, H., B. L. Tremblay, A. M. Paradis, V. Garneau, S. Desroches, J. Robitaille, and M. C. Vohl. "Nutrigenomics - perspectives from registered dietitians: a report from the Quebec-wide e-consultation on nutrigenomics among registered dietitians." Journal of Human Nutrition and Dietetics 27, no. 4 (January 6, 2014): 391–400. http://dx.doi.org/10.1111/jhn.12194.

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27

Arola-Arnal, Anna, and Manuel Suárez. "Do You Have Problems When Reproducing Bioactivities of Food or Food Components? The Importance of Biological Rhythms." Nutrients 14, no. 21 (November 2, 2022): 4607. http://dx.doi.org/10.3390/nu14214607.

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With the onset of omics sciences, in the 20th century, nutritional studies evolved to investigate the effects of diet at a molecular level, giving rise to nutritional genomics, which includes both nutrigenomics and nutrigenetics [...]

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28

Darnton-Hill, Ian, Barrie Margetts, and Richard Deckelbaum. "Public health nutrition and genetics: implications for nutrition policy and promotion." Proceedings of the Nutrition Society 63, no. 1 (February 2004): 173–85. http://dx.doi.org/10.1079/pns2003330.

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The unravelling of the human genome has the potential to radically extend many of the strategies used in public health nutrition to improve health and to increase food availability, accessibility and utilization. The present paper divides nutrigenomics into two broad but differing areas in asking about possible public health applications: (1) the increasing mismatch between population growth and global food security, on top of the already approximately 800 million of the world population who are food insecure; (2) possible responses to the rising prevalence of non-communicable diseases as the Western diet becomes increasingly inappropriate to the needs of those consuming it. It is clear that complex interactions of multiple polymorphisms play a role in how individuals and sub-populations respond to dietary interventions. All these applications present public health and ethical challenges, particularly in ensuring that any benefits that do come from nutrigenomics are not restricted to the wealthy minority of only the affluent nations. The present paper concludes that the public health applications of nutrigenomics are probably at least a decade away, especially for developing countries. Clinical applications are likely to be more immediate, probably resulting in ‘designer diets’ for individuals with particular polymorphisms, but unless governments take on the role of ensuring some extent of equity in access, any benefits are most likely to go to those who can afford the screening, tests and treatment. At the same time, greatly increased international efforts are needed towards the continuing, and in some cases worsening, global malnutrition, as genetic manipulation of crops is unlikely to provide more than part of the solution.

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29

Rosen, Renee, Carrie Earthman, Len Marquart, and Marla Reicks. "Continuing Education Needs of Registered Dietitians Regarding Nutrigenomics." Journal of the American Dietetic Association 106, no. 8 (August 2006): 1242–45. http://dx.doi.org/10.1016/j.jada.2006.05.007.

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30

Afman, Lydia, and Michael Müller. "Nutrigenomics: From Molecular Nutrition to Prevention of Disease." Journal of the American Dietetic Association 106, no. 4 (April 2006): 569–76. http://dx.doi.org/10.1016/j.jada.2006.01.001.

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31

Ryan-Harshman, Milly, Ellen Vogel, Holly Jones-Taggart, Julia Green-Johnson, David Castle, Zubin Austin, and Kristin Anderson. "Nutritional Genomics and Dietetic Professional Practice." Canadian Journal of Dietetic Practice and Research 69, no. 4 (December 2008): 177–82. http://dx.doi.org/10.3148/69.4.2008.177.

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Nutrigenomics is concerned with the role of nutrients in gene expression, and nutrigenetics is the study of how genetic variants or polymorphisms (mutations) can affect responses to nutrients; nutritional genomics is the umbrella term. Nutritional genomics can be expected to revolutionize the way dietitians and other health professionals identify people with chronic diseases and treat those diseases. Understanding the science of nutritional genomics is important to dietitians and other health professionals because major scientific advancements such as this usually have a significant impact on ethics, policy, and practice. Blood lipid profiles are one area in which nutritional genomics has quickly advanced knowledge. New knowledge is available on blood lipid profiles and associated conditions, such as obesity and type 2 diabetes. New technology has also had an impact on policy and practice issues, and ethics is an important issue to consider.

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32

Hesketh, John, Iwona Wybranska, Yvonne Dommels, Maria King, Ruan Elliott, Catalina Pico, and Jaap Keijer. "Nutrient–gene interactions in benefit–risk analysis." British Journal of Nutrition 95, no. 6 (June 2006): 1232–36. http://dx.doi.org/10.1079/bjn20061749.

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Individuals respond differently to nutrients and foods. This is reflected in different levels of benefits and risks at the same intake of a nutrient and, consequently, different ‘windows of benefit’ in terms of nutrient intake. This has led recently to the concept of ‘personalised nutrition’. Genetic factors such as single nucleotide polymorphisms may be one source of this inter-individual variation in benefit–risk response to nutrients. In 2004 a European Union-funded network of excellence in the area of nutrigenomics (European Nutrigenomics Organisation; NuGO) organised a workshop on the role of nutrient–gene interactions in determining benefit–risk of nutrients and diet. The major issues discussed at theworkshop are presented in the present paper and highlighted with examples from the presentations. The overall consensus was that although genetics provides a new vision where genetic information could in the future be used to provide knowledge on disease predisposition and nutritionalrequirements, such a goal is still far off and much more research is required before we can reliably include genetic factors in the risk–benefit assessment of nutrients and diets.

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33

Corthésy-Theulaz, Irène, Johan T. den Dunnen, Pascal Ferré, Jan M. W. Geurts, Michael Müller, Nico van Belzen, and Ben van Ommen. "Nutrigenomics: The Impact of Biomics Technology on Nutrition Research." Annals of Nutrition and Metabolism 49, no. 6 (2005): 355–65. http://dx.doi.org/10.1159/000088315.

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34

Roche, Helen M. "Nutrigenomics—new approaches for human nutrition research." Journal of the Science of Food and Agriculture 86, no. 8 (2006): 1156–63. http://dx.doi.org/10.1002/jsfa.2484.

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35

Schaeufele, E. "24 Nutrigenomics, a contribution to public health." Clinical Nutrition Supplements 5, no. 1 (January 2010): 13. http://dx.doi.org/10.1016/s1744-1161(10)70024-7.

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36

Sales, N. M. R., P. B. Pelegrini, and M. C. Goersch. "Nutrigenomics: Definitions and Advances of This New Science." Journal of Nutrition and Metabolism 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/202759.

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The search for knowledge regarding healthy/adequate food has increased in the last decades among the world population, researchers, nutritionists, and health professionals. Since ancient times, humans have known that environment and food can interfere with an individual’s health condition, and have used food and plants as medicines. With the advance of science, especially after the conclusion of the Human Genome Project (HGP), scientists started questioning if the interaction between genes and food bioactive compounds could positively or negatively influence an individual’s health. In order to assess this interaction between genes and nutrients, the term “Nutrigenomics” was created. Hence, Nutrigenomics corresponds to the use of biochemistry, physiology, nutrition, genomics, proteomics, metabolomics, transcriptomics, and epigenomics to seek and explain the existing reciprocal interactions between genes and nutrients at a molecular level. The discovery of these interactions (gene-nutrient) will aid the prescription of customized diets according to each individual’s genotype. Thus, it will be possible to mitigate the symptoms of existing diseases or to prevent future illnesses, especially in the area of Nontransmissible Chronic Diseases (NTCDs), which are currently considered an important world public health problem.

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37

Meneghel, Paola, Elisa Pinto, and Francesco Paolo Russo. "Physiopathology of nonalcoholic fatty liver disease: from diet to nutrigenomics." Current Opinion in Clinical Nutrition & Metabolic Care 25, no. 5 (September 2022): 329–33. http://dx.doi.org/10.1097/mco.0000000000000859.

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38

Hesketh, John. "Nutrigenomics and Selenium: Gene Expression Patterns, Physiological Targets, and Genetics." Annual Review of Nutrition 28, no. 1 (August 2008): 157–77. http://dx.doi.org/10.1146/annurev.nutr.28.061807.155446.

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39

Nolan, Deborah. "4TH ASIA PACIFIC NUTRIGENOMICS CONFERENCE: 21-24 FEBRUARY 2010, AUCKLAND, NEW ZEALAND." Nutrition & Dietetics 67, no. 3 (August 25, 2010): 196. http://dx.doi.org/10.1111/j.1747-0080.2010.01456.x.

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40

Loos, Ruth J. F. "From nutrigenomics to personalizing diets: are we ready for precision medicine?" American Journal of Clinical Nutrition 109, no. 1 (January 1, 2019): 1–2. http://dx.doi.org/10.1093/ajcn/nqy364.

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41

Kauwell, Gail P. A. "Emerging Concepts in Nutrigenomics: A Preview of What Is to Come." Nutrition in Clinical Practice 20, no. 1 (February 2005): 75–87. http://dx.doi.org/10.1177/011542650502000175.

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42

Pershko, A. M., and I. I. Yarovenko. "Modern nutrigenomics and nutrigenetics and some metabolic aspects of pathogenesis in inﬂammatory bowel diseases: a look into the future." Experimental and Clinical Gastroenterology 183, no. 11 (November 14, 2020): 113–17. http://dx.doi.org/10.31146/1682-8658-ecg-183-11-113-117.

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The implementation of the target setting for the treatment of inﬂammatory bowel diseases — the achievement of clinical and endoscopic remission in each case, even taking into account biological therapy drugs, is not always achievable. It is obvious that patients with ulcerative colitis and Crohn’s disease are genetically heterogeneous in nature, which is manifested by the formation of various clinical and genetic phenotypes and various proﬁles of altered intestinal microbiota. Modern dietetics and nutritionology can be the most important ﬁne-tuning tool in this chain of events and signiﬁcantly increase the eﬀectiveness of the therapy, equally contributing to both normalization of the intestinal microbial community and providing mechanisms for regulating gene expression (epigenetic eﬀect).

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Horne, Justine, Jason Gilliland, and Janet Madill. "Assessing the effectiveness of actionable nutrigenomics and lifestyle genomics interventions for weight management in clinical practice: A critical, scoping review with directions for future research." Nutrition and Health 26, no. 3 (June 5, 2020): 167–73. http://dx.doi.org/10.1177/0260106020928667.

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Background: The use of nutrigenomics and lifestyle genomics in clinical practice has the potential to optimize weight-related outcomes for patients. Aim: A scoping review was conducted to summarize and evaluate the current body of knowledge related to the effectiveness of providing DNA-based lifestyle advice on weight-related outcomes, with the aim of providing direction for future research. Method: Primary studies were included if they were written in English, evaluated weight-related and/or body mass index and/or body composition outcomes, and provided participants with an actionable genetic-based lifestyle intervention; interventions that only provided information on genetic risk for diseases/conditions were excluded. Data was extracted from each article meeting inclusion criteria ( N=3) and the studies were critically appraised for methodological limitations. Results: Research in this area is promising, but limited. Specific limitations relate to study designs, the nature of the recommendations provided to participants, small (underpowered) sample sizes, the use of self-reported weight/BMI data and lack of consideration of important confounding factors. Conclusions: Therefore, the effectiveness of nutrigenomics and lifestyle genomics interventions for weight management in clinical practice cannot yet be conclusively determined. Recommendations for future research are detailed in the present manuscript.

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Antony Dhanapal, Anto Cordelia Tanislaus, and Karani Santhanakrishnan Vimaleswaran. "Vitamin D supplementation and immune-related markers: an update from nutrigenetic and nutrigenomic studies." British Journal of Nutrition 128, no. 8 (October 12, 2022): 1459–69. http://dx.doi.org/10.1017/s0007114522002392.

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Abstract Vitamin D is both a nutrient and a neurologic hormone that plays a critical role in modulating immune responses. While low levels of vitamin D are associated with increased susceptibility to infections and immune-related disorders, vitamin D supplementation has demonstrated immunomodulatory effects that can be protective against various diseases and infections. Vitamin D receptor is expressed in immune cells that have the ability to synthesise the active vitamin D metabolite. Thus, vitamin D acts in an autocrine manner in a local immunologic milieu in fighting against infections. Nutrigenetics and nutrigenomics are the new disciplines of nutritional science that explore the interaction between nutrients and genes using distinct approaches to decipher the mechanisms by which nutrients can influence disease development. Though molecular and observational studies have proved the immunomodulatory effects of vitamin D, only very few studies have documented the molecular insights of vitamin D supplementation. Until recently, researchers have investigated only a few selected genes involved in the vitamin D metabolic pathway that may influence the response to vitamin D supplementation and possibly disease risk. This review summarises the impact of vitamin D supplementation on immune markers from nutrigenetics and nutrigenomics perspective based on evidence collected through a structured search using PubMed, EMBASE, Science Direct and Web of Science. The research gaps and shortcomings from the existing data and future research direction of vitamin D supplementation on various immune-related disorders are discussed.

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Parn, Kim Wai, Wei Chih Ling, Jin Han Chin, and Siew-Keah Lee. "Safety and Efficacy of Dietary Epigallocatechin Gallate Supplementation in Attenuating Hypertension via Its Modulatory Activities on the Intrarenal Renin–Angiotensin System in Spontaneously Hypertensive Rats." Nutrients 14, no. 21 (November 1, 2022): 4605. http://dx.doi.org/10.3390/nu14214605.

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This study aimed to identify the no-observed-adverse-effect level (NOAEL) of dietary epigallocatechin gallate (EGCG) supplementation and its possible antihypertensive and nutrigenomics effects in modulating intrarenal renin-angiotensin system (RAS) gene expression in spontaneously hypertensive rats (SHR). EGCG (50, 250, 500 or 1000 mg/kg b.w. i.g., once daily) was administered to SHR for 28 days. All the SHR survived with no signs of systemic toxicity. Increased alanine aminotransferase (ALT), aspartate aminotransferase (AST) and thiobarbituric acid reactive substances (TBARS) were evident in SHR supplemented with 500 and 1000 mg/kg b.w. but not in those supplemented with lower doses of EGCG. Subsequently, the NOAEL of EGCG was established at 250 mg/kg b.w., and the same protocol was replicated to assess its effects on blood pressure and renal RAS-related genes in SHR. The systolic blood pressure (SBP) of the EGCG group was consistently lower than the control group. The mRNA levels of cortical Agtr2 and Ace2 and medullary Agtr2 and Ace were upregulated while medullary Ren was downregulated in EGCG group. Statistical analysis showed that SBP reduction was associated with the changes in medullary Agtr2, Ace, and Ren. Dietary EGCG supplementation exhibits antihypertensive and nutrigenomics effects through activation of intrarenal Ace and Agtr2 and suppression of Ren mediators, while a high dose of EGCG induced liver damage in SHR. In future clinical studies, liver damage biomarkers should be closely monitored to further establish the safety of the long-term use of EGCG.

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Harrouff, M. N. "The Effect of Nutrigenomics Education on the Dietary Habits of College Students." Journal of the American Dietetic Association 111, no. 9 (September 2011): A47. http://dx.doi.org/10.1016/j.jada.2011.06.165.

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Caio, Giacomo, Lisa Lungaro, Fabio Caputo, Eleonora Zoli, Fiorella Giancola, Giuseppe Chiarioni, Roberto De Giorgio, and Giorgio Zoli. "Nutritional Treatment in Crohn’s Disease." Nutrients 13, no. 5 (May 12, 2021): 1628. http://dx.doi.org/10.3390/nu13051628.

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Crohn’s disease (CD) is a chronic inflammatory bowel disease (IBD) which can affect any part of the whole gastrointestinal tract (from mouth to anus). Malnutrition affects 65–75% of CD patients, and it is now well acknowledged that diet is of paramount importance in the management of the disease. In this review, we would like to highlight the most recent findings in the field of nutrition for the treatment of CD. Our analysis will cover a wide range of topics, from the well-established diets to the new nutritional theories, along with the recent progress in emerging research fields, such as nutrigenomics.

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Ilyina, Irina, Natalya Zaporozhets, and Irina Machneva. "Directed transformation of food raw materials - as a key factor in the transition to “personalized nutrition”." BIO Web of Conferences 46 (2022): 01001. http://dx.doi.org/10.1051/bioconf/20224601001.

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In the article, based on the results of the analysis of the relationship between public health and the nutrition structure of the Russian population, the main problems are identified and tasks in the field of personalized dietetics, functional and specialized nutrition are updated. The key points in solving these problems, taking into account scientific and technological achievements in the field of biochemistry, nutrigenetics, nutrigenomics and nutrimicrobiome in the 21st century, is the transition to "personalized nutrition". The main fundamental tasks in the field of agricultural science are determined, aimed primarily at identifying the patterns of transformation of food raw materials throughout the life cycle in order to create modern forms of food. On the example of pectin, it is shown that the study of the mechanisms and patterns of transformation of pectincontaining raw materials under the influence of physical, chemical, biotechnological methods in cooperation with scientists and specialists in the field of medicine and computer science makes it possible to create pectins with different chemical composition and structure and intended, in particular, for the prevention of intoxication heavy metals and organochlorine pesticides.

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Astley, Siân B., and Ruan M. Elliott. "The European Nutrigenomics Organisation: linking genomics, nutrition and health research." Journal of the Science of Food and Agriculture 87, no. 7 (2007): 1180–84. http://dx.doi.org/10.1002/jsfa.2791.

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Birla, Meghna, Chanchal Choudhary, Garima Singh, Salvi Gupta, Bhawana, and Pratyusha Vavilala. "The Advent of Nutrigenomics: A Narrative Review with an Emphasis on Psychological Disorders." Preventive Nutrition and Food Science 27, no. 2 (June 30, 2022): 150–64. http://dx.doi.org/10.3746/pnf.2022.27.2.150.

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