Dissertations / Theses on the topic 'Diagnostic pathway'
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Martin, Laura. "Insights into the tuberculosis diagnostic pathway." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/33125.
Full textLaird, Madeleine Mackay. "Parental perceptions of a pre-school diagnostic pathway for autism." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/parental-perceptions-of-a-pre-school-diagnostic-pathway-for-autsim(85bcad79-fa33-4b62-95f3-45662cda7021).html.
Full textJohns, Christopher. "Improving the diagnostic pathway of pulmonary hypertension using cardio-pulmonary magnetic resonance imaging." Thesis, University of Sheffield, 2018. http://etheses.whiterose.ac.uk/20207/.
Full textVignali, Giulia. "The Bell Tower: the facts-finding pathway and good practice for the structural diagnostic analysis." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018.
Find full textDickinson, C. L. "The integration of magnetic resonance imaging in the diagnostic and therapeutic pathway for localised prostate cancer." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1464111/.
Full textEliasson, Madeleine. "Recurrent macroscopic hematuria after anegative investigation – diagnostic yield ofrepeat investigation." Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-93341.
Full textKanthabalan, Ana Abhiramy. "The evaluation of a novel imaging-based complex diagnostic and therapeutic pathway intervention for men who fail radiotherapy for prostate cancer." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10057034/.
Full textBauffe, Frédérique. "Etude de protéines parasitaires pour l'amélioration des tests de diagnostic rapide du paludisme." Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM5068.
Full textMalaria is a public health problem in many countries. Five species infect humans: P. falciparum, responsible for the vast majority of deaths, and P. vivax, P. ovale, P. malariae and P. knowlesi causing mild forms of the disease. The diagnostic is a means of control and a medical emergency. The rapid diagnostic tests (RDT) whose are recommended by WHO, are increasingly used. However, the detection and identification of not P. falciparum species is insufficient. New "antigen-antibody" couples are a need to improve the RDTs performance. In this work, new anti LDH antibodies from P. malariae were produced. A search for new antigens was also undertaken. For this purpose, some enzyme of glycolysis pathway were studied. For the first time the sequences of the enzymes from this pathway were obtained for P. ovale and P. malariae. We identified many potential target epitopes specific and common to all those species. In a second step, a proteomics approches has been conducted to identify parasites biomarkers. The study of red blood cells and plasma of infected patients has led to the selection of 8 original target proteins. This work prepares the manufacturing and marketing of a new generation of RDTs for malaria by the company Whidiag
Phyu, Su Myat. "Targeting of the PI3K/AKT/mTOR signalling pathway and associated kinases in breast and colon cancer cells and response evaluation by molecular imaging techniques." Thesis, University of Aberdeen, 2018. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=238576.
Full textMohanty, Sujit Kumar. "A. Genetic characterization of the caffeine C-8 oxidation pathway in Pseudomonas Sp. CBB1 B. Validation of caffeine dehydrogenase as a suitable enzyme for a rapid caffeine diagnostic test." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/4879.
Full textDhillon, Ravinder. "Diagnostic imaging pathways." University of Western Australia. School of Medicine and Pharmacology, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0126.
Full textDhillon, Ravinder. "Diagnostic imaging pathways /." Connect to this title, 2006. http://theses.library.uwa.edu.au/adt-WU2007.0126.
Full textSaville, Christina. "Modelling pathways to diagnosis of breast conditions." Thesis, University of Southampton, 2018. https://eprints.soton.ac.uk/422238/.
Full textBrechbiel, Julia. "Pathways Linking Clinician Demographics to Mental Health Diagnostic Accuracy: An International Perspective." VCU Scholars Compass, 2017. https://scholarscompass.vcu.edu/etd/5120.
Full textTamburrino, Federica <1980>. "I disordini del pathway RAS-MAPK o Rasopatie: aspetti diagnostici, clinici e terapeutici." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7435/.
Full textRASopathies are developmental disorders caused by heterozygous germline mutations in genes encoding proteins in the RAS-MAPK signaling pathway. These conditions share facial dysmorphism, failure to thrive, congenital heart disease, ectodermal, and skeletal anomalies, variable cognitive involvement, and susceptibility to certain malignancies as major characteristics. This study analized clinical features, growth trend and body proportions in 88 patients affected by RASopathies with molecularly confirmed diagnosis, and FH reached in 33, including 16 treated with GH therapy for proven GH deficiency. Clinically, 69 patients (78.4%) had a diagnosis of Noonan syndrome (NS), seven of NS/Loose anagen hair (8.0%), six of CFC syndrome (6.8%), and two of Costello syndrome, Noonan syndrome with multiple lentigines (NSML) and Legius syndrome. Among them, 52 (59.1%) had PTPN11 mutations, while the other genotypes were less than 10%. Most patients were born at term, after a physiological pregnancy and presented regular neonatal adaptation. 75.9% patients had cardiac anomalies and 20.2% needed surgery for cardiac involvement. Thirty-three patients showed GH deficiency after pharmacological tests, and were GH-treated for an average period of 6.8±4.8 years. Before starting therapy, HV was -2.6±1.3 SDS, and mean basal IGF1 levels were -2.0±1.1 SDS. Long-term GH therapy, starting early during childhood, resulted in a positive height response compared with untreated patients (1.3 SDS in terms of height-gain), normalizing FH for Ranke standards but not for general population and Target Height. The delayed pubertal development and the inadequate pubertal catch-up growth could explain the impaired FH. Our patients on GH-therapy benefitted from the pharmacological treatment if started in pre-puberty and given for a long time. Probably, the prepubertal start of GH-treatment could compensate the lack of a pubertal growth. 1/88 patient had cancer, but she didn’t received GH. The patients presented cognitive impairment (41.1%), ADHD (38.8%), SNC anomalies (24.4%) and EEG alterations (6.7%).
Jager-Hyman, Shari Gail. "Nonsuicidal Self-Injury in a College Sample: Risk Factors, Pathways, and Diagnostic Correlates." Diss., Temple University Libraries, 2012. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/201201.
Full textPh.D.
As research on nonsuicidal self-injury (NSSI) is in its beginning stages, relatively little is known about the variables that confer risk for this class of behaviors. Although recent work has implicated the role of childhood maltreatment in the development of NSSI, this body of literature is hampered by several important limitations. These limitations include either grouping together all forms of maltreatment (i.e., emotional, physical, and sexual abuse) or focusing on only one form of maltreatment. In addition, there is a paucity of research exploring the mechanisms by which maltreatment experiences relate to NSSI. Furthermore, although a great deal of attention has focused on the relation between self-harm (both suicidal and nonsuicidal) and specific psychological diagnoses, particularly borderline personality disorder (BPD), the vast majority of this research has been conducted with severe clinical samples. As a result, there is a dearth of knowledge about the risk factors, pathways, and diagnostic correlates of NSSI in non-clinical samples. Given that recent research has suggested that NSSI is increasingly common in college samples, the current study aimed to address these limitations in a diverse sample of 1,819 college students. Participants completed assessments of childhood maltreatment experiences, NSSI, as well as two potential mediators, emotion dysregulation and cognitive vulnerability, and one potential moderator, impulsivity. In addition, a subset of participants (n = 140) were administered diagnostic interviews for BPD and depression. Results provided support for the role of childhood maltreatment in the development in NSSI. Controlling for other forms of maltreatment, emotional maltreatment was most predictive of NSSI. Both emotion dysregulation and negative cognitive style partially mediated the relationship between childhood maltreatment and NSSI. In contrast, impulsivity did not significantly moderate the childhood maltreatment - NSSI relation. As expected, borderline personality features significantly predicted NSSI. However, contrary to expectations, impulsivity and affective instability were not the strongest borderline criteria in the prediction of NSSI. Treatment implications of these results, strengths and limitations, as well as areas of future research are discussed.
Temple University--Theses
Hussin, Duratul 'Ain. "Development and evaluation of optometrist-led referral pathways in Ampang, Malaysia." Thesis, Queensland University of Technology, 2016. https://eprints.qut.edu.au/98401/8/98401.pdf.
Full textVergaro, Giuseppe. "Galectin-3 and aldosterone profibrotic pathways in the failing heart." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC235.
Full textBackgroundGalectin-3 (Gal-3) is biologically linked to the process of inflammation and fibrosis in heart failure (HF). The renin-angiotensin-aldosterone system (RAAS) has been largely demonstrated to exert profibrotic, prohypertrophic and proinflammatory effects in the pathophysiology of HF. Further, there is initial experimental evidence that Gal-3 and RAAS may interplay in the development of cardiovascular damage in hypertensive models. However, such interaction has not been investigated in the setting of left ventricular (LV) dysfunction and HF. We aimed therefore to test the following hypotheses:1. Gal-3 participates in the mechanisms of aldosterone mediated cardiac fibrosis and tissue remodeling in a murine model of LV dysfunction;2. Gal-3 level is associated with the development of LV remodeling and fibrosis and can predict the effects of neurohormonal antagonism in patients with chronic HF due to non-ischemic dilated cardiomyopathy (NIDCM).Methods1. Adult male mice with cardiac-specific hyperaldosteronism (AS) underwent isoproterenol subcutaneous injections (200 mg/kg x 2/day over two days), to be then randomized to receive placebo, a Gal-3 inhibitor (modified citrus pectin, MCP), an aldosterone antagonist (potassium canrenoate), or MCP+canrenoate for 14 days.2. We enrolled 150 patients with a diagnosis of NIDCM. All patients underwent a comprehensive clinical and biohumoral evaluation, including Gal-3 assay, 2-D echocardiography, and a contrast-enhanced cardiac magnetic resonance (CMR) for the assessment of LV volumes and fibrosis by the late gadolinium enhancement (LGE) technique. A smaller cohort of 70 patients also received soluble suppression of tumorigenicity protein 2 (sST2) assay at baseline as well as a follow-up CMR after 24 months for the evaluation of LV reverse remodeling, defined as a >10 percentage units increase in LV ejection fraction or a >10% decrease in LV end-diastolic volume indexed.ResultsIsoproterenol induced a rapid and persistent decrease in LV systolic function which was markedly improved by treatment with either MCP or canrenoate. MCP and canrenoate also reduced cardiac hypertrophy and fibrosis and the expression of genes involved in fibrogenesis (Coll-1 and Coll-3) and macrophage infiltration (CD-68 and MCP-1). The combined use of antagonists of Gal-3 and aldosterone resulted in enhanced effects on cardiac hypertrophy, inflammation, and fibrosis, when compared to MCP or canrenoate alone. In our cohort of NIDCM patients, median Gal-3 value was 14.4 ng/mL; LGE was detected in 106. Patients with LGE had higher Gal-3 than those without (p=0.006). Among univariate predictors of LGE, Gal-3 maintained its predictive value at multivariate analysis, together with sex, hypertension, disease duration and right ventricular ejection fraction. At follow-up CMR, 35 patients showed reverse remodeling. Gal-3, but not sST2 resulted as an independent predictor of LV reverse remodeling at multivariate analysis.ConclusionGal-3 participates in mechanisms of aldosterone-mediated myocardial damage in murine model of HF. Likewise, in the clinical setting of NIDCM, Gal-3 seems to be associated with LV fibrosis and to the evolution of cardiac remodeling, possibly identifying the subset of patients with a more pronounced response to pharmacological neurohormonal antagonism
Perez, Jalessa Ivelis. "DEPRESSION AND ADDICTION: ALONG THE PATHWAY TOWARDS SUICIDE." Case Western Reserve University School of Graduate Studies / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1546606105783207.
Full textHo, Ka-yan Rebecca Lucinda, and 何嘉茵. "Mutations of epidermal growth factor receptor (EGFR) pathway genes andMET in primary lung adenocarcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48333906.
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Pathology
Master
Master of Medical Sciences
Elakad, Omar [Verfasser]. "Functional and diagnostic relevance of FGFR1-dependent signaling pathways in squamous cell lung cancer / Omar Elakad." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2020. http://d-nb.info/1218299207/34.
Full textHarman, David J. "The identification of chronic liver disease in primary care using non-invasive diagnostics within a novel pathway." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/36459/.
Full textBurkitt, Wright Emma Mary Milborough. "De novo germline disorders of the Ras-MAPK pathway : clinical delineation, molecular diagnosis and pathogenesis." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/de-novo-germline-disorders-of-the-rasmapk-pathwayclinical-delineation-molecular-diagnosis-and-pathogenesis(9688dc20-7b1b-46f1-a638-b4d1809f430b).html.
Full textCanatsey, Ryan Douglas. "Combination Therapeutic Strategies Targeting Growth and Metabolic Pathways in Prostate Cancer." Diss., The University of Arizona, 2016. http://hdl.handle.net/10150/613236.
Full textBungay, Hilary. "Pathways in the diagnosis and treatment of breast cancer : the significance of delay." Thesis, University of Kent, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369686.
Full textHumphrys, Elka Suzanne. "Understanding the pathways to oesophageal and stomach cancer diagnosis : a multi-methods approach." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/289397.
Full textWilne, Sophie Helen. "The Pathways Project : developing guidelines to facilitate the diagnosis of childhood brain tumours." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/2881/.
Full textWikström, Git. "Women’s Perspectives on Pathway to Diagnosis of Pulmonary Tuberculosis : Women Voices from Community Level in Uganda." Thesis, Nordic School of Public Health NHV, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:norden:org:diva-3116.
Full textISBN 978-91-86739-19-5
Ayre, Colin A. "Delay to diagnosis and specialist consultation following anterior cruciate ligament injury : a study investigating the nature of, and factors associated with, pathway delay." Thesis, University of Bradford, 2016. http://hdl.handle.net/10454/14627.
Full textKarnam, Anupama. "Role of Wnt/β-catenin pathway in the anti-inflammatory mechanism of therapeutic normal immunoglobulins Wuchereria bancrofti filaria activates human dendritic cells and polarizes T helper 1 and regulatory T cells via toll-like receptor 4 Regulatory T cells induce activation rather than suppression of human basophils." Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS642.
Full textIntravenous immunoglobulin (IVIG) is a therapeutic preparation of pooled normal IgG obtained from the several thousand healthy donors. It is established as first-line therapy for many autoimmune and inflammatory diseases. In the first part of my thesis, I have investigated if IVIG therapy interferes with the serological detection of Zika virus infection in Guillain–Barré syndrome (GBS) patients. By analyzing the plasma of GBS patients treated with IVIG for anti-Zika IgG, I have demonstrated that IVIG therapy in GBS patients does not interfere with the serological Zika detection. The second part addresses the immunoregulatory role of IVIG on human basophil function. Unlike in mice, IVIG does not require DC-SIGN-dependent IL-33 for the activation of human basophils. IVIG directly induces the activation of IL-3-primed human basophils and secretion of IL-4, IL-6, and IL-8 by directly interacting with the basophil surface-bound IgE. This function was F(ab’)2-dependent and involves Syk activation. These results demonstrate a novel mechanism of human basophil activation by IVIG. The last part unravels the signaling pathways associated with IVIG-mediated anti-inflammatory effects specifically the Wnt/β-catenin pathway, which imparts tolerogenic properties to dendritic cells (DCs) and protection against experimental autoimmune encephalomyelitis (EAE). My data shows that IVIG activates β-catenin in human DC along with upregulation of Wnt 5a. Activation of β-catenin requires intact IgG and LRP5/6 co-receptors. However, despite the activation of β-catenin by IVIG, this pathway is dispensable for its anti-inflammatory actions both in vitro and in vivo in the EAE model
Adair, Carole. "Parental perceptions of the efficacy of diagnostic and educational pathways for children with autistic spectrum disorder in Northern Ireland." Thesis, University of East London, 2010. http://roar.uel.ac.uk/3139/.
Full textYilma, Lemma. "Pathways to diagnosis and treatment : TB patients' experiences in London : a narrative enquiry and analysis." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2011. http://researchonline.lshtm.ac.uk/1379947/.
Full textMarinskis, Germanas. "Tachikardijų elektrofiziologinė diagnostika ir nemedikamentinis gydymas." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2009. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2009~D_20090408_085250-65904.
Full textThis paper reviews the 1991−2008 experience with non-pharmacological treatment of supraventricular and ventricular tachycardias in the Clinic of Heart and vessel diseases of Vilnius University. We summarized the results of managing 1693 patients: 753 patients with atrioventricular nodal tachycardia, 657 patients with accessory pathways, 169 patients with ventricular tachycardias, and 118 patients with implanted cardioverter defibrillators. We have shown that the success rate of catheter ablation for atrioventricular nodal tachycardia is 99.2% with complication rate 0.53%. The safety of ablating the “slow” pathway in patients with prolonged PQ interval has been shown. The success rate of catheter ablation of accessory pathways is 98.1% with 1.7% complication rate. The most complex accessory pathway localization for ablation was posteroseptal area and midseptal area (the latter because of the risk to induce a complete atrioventricular block). The result of catheter ablation for ventricular tachycardia depends on etiology. For “idiopathic” ventricular tachycardias success rate exceeds 90%. In patients with coronary heart disease and cardiomyopathies, catheter ablation is less effective (60%). During the follow-up with duration up to 11 years, 68.6% of patients with implanted cardioverter defibrillators have experienced therapy delivered by the device.
Jagoret, Patrick. "Analyse et évaluation de systèmes agroforestiers complexes sur le long terme : application aux systèmes de culture à base de cacaoyer au Centre Cameroun." Thesis, Montpellier, SupAgro, 2011. http://www.theses.fr/2011NSAM0012.
Full textCocoa cultivation is generally considered as one of the main deforestation factors in the Tropics. Indeed, in many countries it is based on a low-sustainability technical model of intensive monocrops with shifting production zones. Cocoa agroforests, which are often neglected by research due to their low fermented dried cocoa yields, now appear to be a credible alternative for taking up the new challenges facing world cocoa production. In Centre-South Cameroon, cocoa cultivation is largely based on old cocoa agroforests, which suggests that a sustainable cocoa growing model based on agroforestry systems is possible. Our aim was to more effectively understand how these cocoa agroforests function, through their characteristics, their evolution and their determinants, along with the conditions for their long-term fermented dried cocoa production. Our approach consisted of an evaluation of cocoa agroforests on a plot scale and a comprehensive analysis of technical practices over the long term. The thesis is based on an experimental design set up in the Centre region, in three growing zones that could be differentiated through their pedo climatic conditions (Bokito, Zima and Ngomedzap). A large-scale survey was undertaken (1,171 farms grouping 1,638 cocoa plantations) completed by specific observations collected in a network of 61 cocoa agroforests managed by 40 farmers. Results. (1) Our survey results, completed by specific observations, confirmed the sustainability of the cocoa agroforestry systems from an agro ecological and socio-economic viewpoint. (2) In the forest-savannah transition zone, which is considered sub-optimum for cocoa cultivation, we confirmed that the technical model adopted by the farmers enabled them to set up cocoa agroforests on savannah that were viable over the long term. (3) In the network, a participatory method applied to quantify the use value given to the species by the farmers confirmed the multi-functionality of cocoa agroforests and measured the place occupied in it by cocoa. (4) The evaluation of the cocoa tree stands, achieved by adapting the regional agronomic diagnosis method to complex systems, revealed the factors limiting cocoa yield. It was proved that cocoa yield is closely linked to the structure of the cocoa tree stand and that of the intercropped stands. (5) Lastly, a comprehensive analysis of farmer practices over the long term, in association with the evolution of the technical management of the cocoa tree stands, confirmed the flexibility of cocoa agroforestry systems. This flexibility was reflected in the evolution pathways for specific practices and structures. This work provides a new methodological basis to assess the performance of complex agroforestry systems. All the results and knowledge produced by this work make it possible to draw up proposals for developing a new technical model for cocoa growing
Namaki, Araghi Sina. "A methodology for business process discovery and diagnosis based on indoor location data : Application to patient pathways improvement." Thesis, Ecole nationale des Mines d'Albi-Carmaux, 2019. http://www.theses.fr/2019EMAC0014.
Full textBusiness processes are everywhere and, as such, we must acknowledge them. Among all of them, hospital processes are of vital importance. Healthcare organizations invest huge amount of efforts into keeping these processes under control, as the allowed margin of error is so slight. This research work seeks to develop a methodology to endorse improvement of patient pathways inside healthcare organizations. It does so by using the indoor location data of patients. This methodology is called DIAG (Data state, Information state, Awareness, Governance). It is constructed of several different functions. The most important ones are as follows: (i) location data interpreting, (ii) automatic discovery of business process models, (iii) business process analyzing for evaluating the performance and quality of processes, and finally, (iv) automatic diagnosing of business processes. Along the former functions, the contribution of this thesis are: The DIAG methodology which, through four different states, extracts knowledge from location data; the DIAG meta-model which supports both the interpretation of location data (from raw data to usable information) and the alignment of the domain knowledge (which are used for the diagnosing methods); two process discovery algorithms which explore statistical stability in event logs, application of Statistical Process Control (SPC) for the “enhancement notation” of Process Mining; the ProDIST algorithm for measuring the distance between process models; two automatic process diagnosing methods to detect causes of structural deviations in individual cases and common processes. The state of the art in this dissertation endorses the necessity for proposing such solutions. A case study within this research work illustrates the applicability of the DIAG methodology and its mentioned functions and methods
Yeung, Yuet-wah, and 楊月華. "Role of social networks in the pathway to care of Chinese people living with a diagnosis of severe mental illness in England." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hub.hku.hk/bib/B50662314.
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Social Work and Administration
Doctoral
Doctor of Philosophy
Oliveira, Elaine Aparecida de. "Desenvolvimento e avaliação de uma ferramenta para diagnostico da literacia visual, contextualizada no estudo de vias metabolicas." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314741.
Full textDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia
Made available in DSpace on 2018-08-15T17:08:58Z (GMT). No. of bitstreams: 1 Oliveira_ElaineAparecidade_M.pdf: 4028860 bytes, checksum: 12a75ba90b00d8eded4dc1107cc6168a (MD5) Previous issue date: 2010
Resumo: Representações externas são muito utilizadas no ensino de bioquímica. As vias metabólicas constituem um tipo de representação externa e envolvem habilidades visuais; estão, portanto, intimamente relacionados à literacia visual (capacidade de interpretar imagens). Há uma preocupação crescente em diagnosticar a dificuldade dos estudantes com a bioquímica. Este tipo de diagnóstico é importante para poder propor soluções pedagógicas que possam facilitar o aprendizado. O presente trabalho tem como objetivo descrever o desenvolvimento e a aplicação de um teste informatizado para diagnosticar a literacia visual, relacionada ao estudo de vias metabólicas, de estudantes de cursos das áreas biológica e da saúde. Inicialmente foram desenvolvidos testes piloto com itens (modelos e questões) que contemplavam habilidades visuais para a compreensão de vias metabólicas mais frequentemente representadas em livros didáticos de bioquímica. Os testes piloto foram aplicados em 2007 e 2008 com turmas de graduação de cursos da área biológica e da saúde. Os resultados obtidos serviram de subsídio para que alguns itens fossem reformulados e outros adicionados. Os resultados obtidos foram tratados com uso do modelo de Rasch, tanto no processo de equalização dos testes piloto (para definir os itens do teste final), como para o tratamento dos resultados obtidos com a calibração de itens-respondentes após as aplicações do teste final. Três grupos participaram da aplicação do teste final e compreenderam 79 estudantes distribuídos entre os cursos de educação física (UNICAMP), enfermagem (UNICAMP) e fisioterapia/nutrição (FAJ). A partir dos dados obtidos utilizou-se o processo de calibração de itens-respondentes, proposta pelo modelo de Rasch, obtendo-se a dificuldade dos itens e as habilidades visuais apresentadas pelos grupos. Os resultados observados sugerem que entre as dificuldades apresentadas pelos estudantes no aprendizado de metabolismo pode ser incluída a dificuldade em se compreender as representações externas de vias metabólicas. Essa dificuldade pode ser minimizada com explicações dos modelos antes de se entrar nos conteúdos específicos. O teste produzido permite o diagnóstico de estudantes ou de grupos. A necessidade de desenvolver práticas de visualização para melhorar a compreensão de conceitos bioquímicos pelos estudantes mostrou-se um aspecto importante no estudo de vias metabólicas
Abstract: External representations are used in teaching of biochemistry. The metabolic pathways are a type of external representation and involve visual skills, are therefore closely related to visual literacy (ability to interpret images). There is an increasing concern regarding the diagnosis of students with difficulty to the biochemistry, this type of diagnosis is important to be able to propose solutions that would facilitate learning. This paper aims to describe the development and implementation of a computerized test to diagnose the visual literacy, related to the study of metabolic pathways for undergraduate students enrolled in courses in the biological and health. Initially, pilot tests have been developed with (models and items) that looked visual skills for the understanding of metabolic pathways most often represented in textbooks of biochemistry. The pilot tests were applied in 2007 and 2008 on undergraduate classes of various courses in the biological and health. The results served as a subsidy for some items were reformulated and others added. The results are processed using the Rasch model, both in the process of equalizing the pilot tests (for set of the final test) and for the treatment of the results obtained with calibration of items-respondents the applications for the final test. Three groups participated in the implementation of the final test and included 79 students distributed among the courses of physical education (UNICAMP), nursing (UNICAMP) and physiotherapy/nutrition (FAJ). From the data we used the calibration of items-respondents proposed by Rasch model resulting in the difficulty of items and visual skills presented by the groups. The results suggest that among the difficulties presented by the students in the learning of metabolism may be included the difficulty in understanding the external representations of metabolic maps. This difficulty can be minimized with the explanations of the models before they enter the specific content. The test produced allows the diagnosis of students or groups. The need of developing imagery to improve the understanding of biochemical concepts by students were an important aspect in the study of metabolic pathways
Mestrado
Bioquimica
Mestre em Biologia Funcional e Molecular
Jordan, Sumanas W. "A mathematical model of tissue factor-induced blood coagulation: discrete sites of initiation and regulation under conditions of flow." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/33907.
Full textBailey, Janelle Lee. "Language Pathways Defined in a Patient with Left Temporal Lobe DamageSecondary to Traumatic Brain Injury: A QEEG & MRI Study." BYU ScholarsArchive, 2014. https://scholarsarchive.byu.edu/etd/4363.
Full textPowell, Tim. "Investigating the molecular underpinnings of major depressive disorder and the utility of biomarkers in the inflammatory cytokine pathway as aids for clinical diagnosis and treatment selection." Thesis, King's College London (University of London), 2014. https://kclpure.kcl.ac.uk/portal/en/theses/investigating-the-molecular-underpinnings-of-major-depressive-disorder-and-the-utility-of-biomarkers-in-the-inflammatory-cytokine-pathway-as-aids-for-clinical-diagnosis-and-treatment-selection(c75d417f-13f8-4618-91de-96ce798a8336).html.
Full textPorchet, Nicolas. "Role of signaling pathays in cell-fate specification in the early mouse embryo." Thesis, Université de Paris (2019-....), 2019. http://www.theses.fr/2019UNIP7096.
Full textDuring the early mouse embryogenesis, cell-fate specification events result in the formation of the pre-implantation blastocyst. Those events are mainly regulated by the action of signaling cascades activated upon fixation of the signaling molecules at the cell membrane. The activity of these signaling pathways allow the transcriptional regulation of a specific pool of genes responsible for cell-fate decisions and the formation of tissues. Here, I am interested in the roles of both ACTIVIN/NODAL and βCATENIN signaling pathways in the specification of cell identities during the maturation of the mouse blastocyst
O'Donnell, Melissa. "Towards prevention - a population health approach to child abuse and neglect : health indicators and the identification of antecedent causal pathways." University of Western Australia. School of Paediatrics and Child Health, 2009. http://theses.library.uwa.edu.au/adt-WU2010.0029.
Full textPetkova, Hristina. "How gene tests travel : bi-national comparison of the institutional pathways taken by diagnostic genetic testing for Maturity Onset Diabetes of the Young (MODY) through the British and the German health care system." Thesis, University of Exeter, 2008. http://hdl.handle.net/10036/47558.
Full textHill, Owen T. "Improving prostate cancer detection in veterans through the developement of a clinical decision rule for prostate biopsy." [Tampa, Fla] : University of South Florida, 2006. http://purl.fcla.edu/usf/dc/et/SFE0001575.
Full textOliveira, Joana Isabel Remoaldo. "Lesões endo-perio." Master's thesis, [s.n.], 2014. http://hdl.handle.net/10284/4586.
Full textIntrodução: Este trabalho teve como objetivo a realização de uma revisão de literatura sobre a doença endo-perio. Nesta medida, foram exploradas as relações biológicas entre a polpa e o periodonto, nomeadamente as vias de comunicação existentes, os fatores que contribuem para o seu aparecimento, persistência e/ou agravamento, tendo sido sublinhados os factores etiológicos e a influência da patologia pulpar no periodonto e viceversa. Foram, também, referidas as principais classificações das lesões endo-perio e a problemática do diagnóstico, tratamento e prognóstico dos dentes envolvidos. Materiais e métodos: Esta revisão foi realizada com o limite temporal de 1975 a 2014, recorrendo ao motor de busca Google e às bases de dados Medline/ PubMed, B-on, Science direct, utilizando as seguintes palavras-chave: endo-perio lesions, classification of endo-perio lesion, microbiology, pathways of communication, diagnosis in endoperio lesions, treatment of endo-perio lesions. Após a leitura dos resumos, a seleção dos artigos foi efectuada de acordo com a especificidade do tema e com os limites temporais acima referidos. Foram, ainda, consultados livros na área de Endodontia na biblioteca da FCS-UFP. Os critérios de exclusão dos artigos foram os artigos pagos e aos quais não se obteve resposta por parte dos seus autores e os que não abordassem directamente o tema em estudo. Resultados: Na literatura consultada, a principal causa apontada para as lesões é de origem microbiana: a microbiologia de lesões endo-perio combinadas, dominada por anaeróbios facultativos e/ou obrigatórios, reflete a microbiota da lesão endodôntica e periodontal em separado e permite infeção cruzada entre o canal radicular e a bolsa periodontal. Os tratamentos endodônticos inadequados, as infiltrações coronais, o atraso da colocação da restauração definitiva, as características anátomo-morfológicas do sistema de canais radiculares, as obturações anteriores, as técnicas de instrumentação e de obturação e a escolha dos materiais, são factores amplamente referidos na literatura que influenciam as falhas do tratamento. Enquanto a polpa mantém funções vitais, mesmo com infeção, a probabilidade desta causar problemas no periodonto é baixa; pelo contrário, a necrose pulpar já é, frequentemente, associada a inflamação do tecido periodontal. Conclusões: Como principal conclusão, deve ser salientado o facto da polpa e do periodonto se constituírem como uma unidade biológica contínua, com múltiplas vias de comunicação, pelo que as doenças pulpares e as doenças periodontais podem influenciarse mutuamente. Pode, igualmente, ser realçado que as doenças endodôntica, periodontal e endodôntica- -periodontal podem apresentar os mesmos sintomas, aspectos radiográficos e sinais clínicos muito semelhantes, sendo que o tratamento e o prognóstico dependem, em primeiro lugar, do diagnóstico da doença endodôntica e/ou periodontal específica, pelo que os principais fatores a considerar na tomada de decisão do tratamento devem ser a vitalidade pulpar e também o tipo e extensão da doença periodontal. A classificação mais utilizada pela maioria dos autores e nos livros da área é a de Simon et al. 1972, que se baseia nos fatores etiológicos e descreve o desenvolvimento deste tipo de lesões; no entanto, os seus fatores etiológicos e os seus padrões patológicos são muito diversos, facto que, ainda, não permitiu o aparecimento de uma classificação totalmente satisfatória. Introduction: This study aimed to conduct a literature review regarding the perio-endo disease. To this extent, the biological relationship between the pulp and the periodontium were explored, including the existing means of communication, the factors that contribute to its onset, persistence and / or worsening, and highlighting the etiological factors and the influence of pulp pathology in the periodontium and vice versa. The main classifications of endo-perio lesions were presented along with the problem of diagnosing, treating and the prognosis of teeth involved. Materials and Methods: This review was performed with the time limit of 1975 to 2014, using the search engine Google and several databases such as Medline / PubMed, B-on, ScienceDirect using the following keywords: endo-perio lesions, classification of endoperio lesion, microbiology, pathways of communication, diagnosis in endo-perio lesions, treatment of endo-perio lesions. After reading the abstracts, the selection of articles was performed according to the specificity of the topic and the time limits mentioned above. Books in the field of endodontics were also consulted in the FCSUFP library. Excluding criteria was used on articles that needed purchase and to which there was no response on the part of their authors and on the ones that didn’t directly address the topic under study. Results: In this review, the main reason given for the lesions is of microbial origin: the microbiology of combined endo-perio lesions that are dominated by facultative and / or strict anaerobes, reflects the microbiota of endodontic and periodontal lesion separately and allows cross-infection between the root canal and the periodontal pocket. Inadequate endodontic treatment, coronal leakage, delay placing the final restoration, the anatomical and morphological characteristics of the root canal system, previous fillings, technical instrumentation and obturation, and the choice of materials, are widely referred to factors in literature that influence treatment failures. As long as the pulp retains vital functions, even when infected, the likelihood of this infection causing problems in the periodontium is low; in contrast, pulp necrosis is often associated with tissue inflammation of the periodontium. Conclusions: As the main conclusion, it should be emphasized that the pulp and periodontium are constituted as a continuous biological unit, with multiple communication paths, so the pulp diseases and periodontal diseases can have a mutual influence. It may also be noted that the endodontic, periodontal and endodontic-periodontal diseases may present the same symptoms, radiographic features and similar clinical signs, therefore the treatment and prognosis depend, firstly on the diagnosis of the specific endodontic and/or periodontal disease, and the main factors to consider in making the decision to treat should be the pulp vitality and also the type and extent of periodontal disease. The classification used by the majority of authors and books in the area is that of Simon et al. 1972, which is based on etiological factors and describes the development of such injuries; however, their etiological factors and their pathological patterns are very diverse, which makes it difficult to have a fully satisfactory classification.
Hajdarevic, Senada. "Patient and health care delays in malignant melanoma." Doctoral thesis, Umeå universitet, Dermatologi och venereologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-54392.
Full textBakgrund: Malignt melanom (MM) är till skillnad från andra cancerformer ofta synlig och kan enkelt och kostnadseffektivt botas om det behandlas i tid. En optimal prognos av MM förutsätter tidig upptäckt, diagnos och behandling. Patienter, samt hälso- och sjukvården, dess organisation och dess personal kan på olika sätt bidra till fördröjning av behandlingen av MM. Syfte: Det övergripande syftet med denna avhandling var att undersöka orsaker till fördröjning att söka vård, diagnosticera och behandla malignt melanom. Specifika delsyften var: Att utforska patienternas beslutsfattande process att söka vård för MM Att identifiera specifika mönster i beslutsfattande-processen att söka vård för misstänkt MM utifrån kvinnors och mäns egna berättelser Att jämföra självrapporterade coping-stilar i den beslutsfattande processen mellan män och kvinnor i olika åldrar, boende med eller utan partner, och diagnosticerade med MM i olika stadier från norra Sverige Att beskriva och jämföra patienter med MM utifrån deras primära vårdkontakt samt utifrån ålder, kön, MM-typ och tjocklek. Ytterligare att utforska vård- och remissvägar samt tidsintervaller mellan olika kliniker från första kontakt till diagnos och behandling. Metod: I studie I och II, intervjuades 21 respektive 30 patienter om den beslutsfattande processen att söka vård för MM. Genuskonstruktioner i relation till den beslutsfattande processen var i fokus i studie II. Intervjuerna analyserades med hjälp av Grounded Theory (I) och kvalitativ innehållsanalys (II). I studie III inkluderades 270 patienter med MM som besvarade ett instrument (MDMQ) avseende coping-stilar i beslutsfattande processen. I studie IV undersöktes övergångar mellan olika kliniker och remissvägar för 71 patienter med MM samt eventuell tidsfördröjning inom hälso- och sjukvården. Resultat: I studie I, identifierades insikt i allvarlighetsgrad samt rädsla och existentiellt hot till följd av tillståndet vara nyckel-motivatorer för att bestämma sig för att söka vård för misstänkt hudmelanom. Resultat från studie II påvisade att genuskonstruktioner påverkar hur personer söker vård för MM. Kvinnor upptäckte själv sina melanom och försökte tillämpa egenvård i början. De kunde dröja att söka vård pga. ansvar för familjen. Män upptäckte sällan suspekta melanom själva men följde oftast anhörigas råd att söka vård och sökte vård omedelbart efter påstötning. Resultaten från studie III visade att män i högre grad använde en avvaktande startegi (buck-passing) medan kvinnor och de som bodde utan partner var överdrivet vaksamma (hypervigilance). Deltagare med nodulärt melanom (NM), en snabbt växande form av MM, var mer vaksamma (vigilance) jämfört med de med melanom in situ, en mycket tidig form av melanom. Några korrelationer mellan tumörtjocklek och coping-stilar hittades ej. Vissa skillnader avseende typer av MM samt vårdens handläggning beroende på var patienter initialt sökt vård identifierades i studie IV. Bland patienter som initialt sökt vård på hälsocentralerna var tjockare tumörer vanligare jämfört med dem som hade sökt vård på hud- och andra specialistklinker. Dessa patienter hade också som regel genomgått den primära excisionen på hälsocentralerna och en majoritet blev senare remitterade till kirurgisk klinik för utvidgad excision. Hälsocentralernas patienter fick vänta längre på att det histopatologiska svaret registrerades i journalen än sjukhusklinikernas patienter. Kvinnor fick generellt vänta kortare tid på primär excision och äldre patienter fick vänta längre för utvidgad excision. Slutsatser: Tidsfördröjning av diagnos och behandling av MM är fortfarande vanlig och därför viktig att minska. Framtida interventioner för att påverka människor att söka vård tidigare bör inkludera genusaspekter. Inom hälso- och sjukvården kan tidsfördröjning minskas genom förbättrad tillgänglighet för patienter med misstänkta hudmelanom, men också genom minskning av onödig remittering. En förändrad organisation där sjuksköterskor och primärvårdsläkare i samarbete med specialistkliniker stöttas att använda ny teknologi för snabbare diagnosticering och omhändertagande av MM bör övervägas. Ökad kännedom bland hälso- och sjukvårdspersonal om riktlinjer for MM-vård kan vidare minska fördröjning. Till sist, mer effektiva och förbättrade arbetssätt kring registrering och överföring av laboratoriska svar och remisser skulle kunna minska fördröjning och därmed öka patientsäkerheten.
Sanches, Seisse Gabriela Gandolfi. ""Efeito de supressão das emissões otoacústicas transientes em crianças com distúrbio de processamento auditivo"." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-18042006-162330/.
Full textThis study concerns the suppression of transient evoked otoacoustic emissions by contralateral white noise in children with auditory processing disorder. Fifty-one children between 7 and 11 years old were assessed, being 15 children without auditory complaints (control group) and 36 with auditory processing disorder (divided in two experimental groups). The mean suppression of otoacoustic emissions and standard deviation were determined for each group, both in linear and nonlinear acquisition mode. The results provided evidence that proportion of absence of otoacoustic emissions suppression was significantly higher in auditory processing disorder groups, when compared to control group
Travers, Simon. "Stéroïdomique corticosurrénalienne par LC-MS/MS : applications en endocrinologie pédiatrique Multiplexed Steroid Profiling of Gluco- and Mineralocorticoids Pathways Using a Liquid Chromatography Tandem Mass Spectrometry Method Urinary Steroidomic Profiles by LC-MS/MS to Monitor Classic 21-Hydroxylase Deficiency Interaction between Accumulated 21-Deoxysteroids and Mineralocorticoid Signaling in 21-Hydroxylase Deficiency Comparative Profiling of Adrenal Steroids in Maternal and Umbilical Cord Blood Alterations of Adrenal Steroidomic Profiles in Preterm Infants at Birth." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASL019.
Full textCorticosteroidogenesis is the synthesis of aldosterone, a hydroelectrolytic homeostasis regulatory hormone, and the stress hormone cortisol involved in many physiological processes. Its exhaustive exploration requires a precise dosing of the steroid precursors, some of which, in pathology, may be deficient or, on the contrary, accumulate with serious deletorious clinical consequences. Thanks to liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS), we have developed two methods for mapping plasma and urinary steroidomic and for the determination of fludrocortisone from a small sample volume. We have demonstrated the usefulness of this method in screening and monitoring of 21-hydroxylase block and have described a prolonged accumulation of synthetic precursors including 21-deoxysteoid derivatives in patients with poorly controlled disease. We showed the partial antagonistic action of these compounds leading to an interference with mineralocorticoid signaling and potentially worsening the symptomatology.In a second step, our LC-MS/MS assay method allowed us to explore perinatal corticosteroidogenesis. The comparison of maternal and fetal steroidomes of term pregnancies clarified the cooperation existing between maternal-fetal-placental steroidogenesis and the study of the steroidomic profiles of 152 newborns of the PREMALDO cohort confirmed the existence of a overall defect in corticosteroid synthesis during prematurity and identified for the first time a partial deficiency in the P450c11b; enzyme, responsible for cortisol synthesis, in these newborns.Finally, we identified a new potential regulator of steroid secretion: adrenomedullin (ADM). Negatively correlated with gestational age in the PREMALDO cohort and cortisol concentrations, ADM inhibits the glucocorticoid pathway in human adrenal HAC15 cells.Steroidomic analysis by LC-MS/MS is now the gold-standard in endocrine investigation, in both clinical biology and fundamental research
Stewart, Heather G. "Amyotrophic lateral sclerosis (ALS) associated with superoxide dismutase 1 (SOD1) mutations in British Columbia, Canada : clinical, neurophysiological and neuropathological features." Doctoral thesis, Umeå : Dept. of Pharmacology and Clinical Neurosciences, Umeå University, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-638.
Full textAgarwala, Sandip. "System Support for End-to-End Performance Management." Diss., Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/16171.
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