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Dissertations / Theses on the topic 'Diagnostic bias'

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Author: Grafiati

Published: 10 December 2022

Last updated: 28 January 2023

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1

LaRue, Gillian Christina. "Misdiagnosing Borderline Personality Disorder: Does Setting Bias and Gender Bias Influence Diagnostic Decision-Making?" Wright State University Professional Psychology Program / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=wsupsych1562840248763243.

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2

Parmley, Meagan Carleton Herbert James D. "The effects of the confirmation bias on diagnostic decision making /." Philadelphia, Pa. : Drexel University, 2006. http://hdl.handle.net/1860/1164.

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3

Perry, Sharon. "The role of diagnostic spectrum bias in cost-effectiveness analysis /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1999. http://wwwlib.umi.com/cr/ucsd/fullcit?p9944225.

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4

Thomas, Richard. "A comparison of methodologies in a diagnostic overshadowing study : clinical impressions of short case presentations." Thesis, University of Southampton, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288441.

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5

Lu, Ying 1968. "Bayesian estimation of diagnostic test parameters in the presence of verification bias." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=98755.

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The statistical evaluation of diagnostic tests may be affected by several potential biases. These biases include those caused by a study design that results in a non-representative sub-sample who are further verified by the reference test (verification bias), and those caused by the absence of a definitive diagnostic test (gold standard test) for many diseases and conditions. In practice, an imperfect reference test is often assumed to be a perfect gold standard, potentially resulting in a large bias. Both Bayesian and frequentist methods have been proposed to adjust for each of these biases independently. To our knowledge, there is no Bayesian solution for that adjusts for both of these biases simultaneously. The objective of this thesis is to present a Bayesian method for the evaluation of diagnostic tests when both of these potential biases may be operating simultaneously. We develop a likelihood function that models both sources of bias, and suggest convenient prior distributions that simplify deriving posterior distributions. The models are based on dichotomous test results and the parameters of interest are estimated using a Gibbs sampler. Using both simulated and real data examples, we demonstrate that the method presented here can correct the verification bias even when a perfect gold standard test does not exist.

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6

Alonzo, Todd Allen. "Assessing accuracy of a continuous medical diagnostic or screening test in the presence of verification bias /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/9600.

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7

Kan, Hongjun. "Does the Medicare principal inpatient diagnostic cost group model adequately adjust for selection bias?" Santa Monica, CA : RAND Graduate School, 2002. http://catalog.hathitrust.org/api/volumes/oclc/50711061.html.

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8

Adams, Pamela (Pamela Ann). "Bias in the Diagnosis and Treatment of Gay Males." Thesis, University of North Texas, 1996. https://digital.library.unt.edu/ark:/67531/metadc278199/.

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The purpose of this study was to explore heterosexual bias in the diagnosis and treatment of gay males. Two hundred-fifty (134 males and 116 females) mental health professionals from the Division of Psychotherapy (29) of the American Psychological Association participated in the study. Participants were randomly assigned to one of two case history conditions, which presented a 35-year-old male seeking therapy. Both conditions were equivalent with regards to the presenting problem (i.e., diagnostic symptoms) with the exception of his significant other (i.e., gay vs. non-gay condition). Potential bias was measured through a diagnostic rating Likert scale and a treatment plan questionnaire. Other independent variables that could potentially have an effect on diagnostic ratings were explored, such as gender, year of graduation, and theoretical orientation of the respondents. Results of the statistical analyses failed to confirm evidence of heterosexual bias. Implications for further research and training are discussed.

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9

Wang, Binhuan. "Statistical Evaluation of Continuous-Scale Diagnostic Tests with Missing Data." Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/math_diss/8.

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The receiver operating characteristic (ROC) curve methodology is the statistical methodology for assessment of the accuracy of diagnostics tests or bio-markers. Currently most widely used statistical methods for the inferences of ROC curves are complete-data based parametric, semi-parametric or nonparametric methods. However, these methods cannot be used in diagnostic applications with missing data. In practical situations, missing diagnostic data occur more commonly due to various reasons such as medical tests being too expensive, too time consuming or too invasive. This dissertation aims to develop new nonparametric statistical methods for evaluating the accuracy of diagnostic tests or biomarkers in the presence of missing data. Specifically, novel nonparametric statistical methods will be developed with different types of missing data for (i) the inference of the area under the ROC curve (AUC, which is a summary index for the diagnostic accuracy of the test) and (ii) the joint inference of the sensitivity and the specificity of a continuous-scale diagnostic test. In this dissertation, we will provide a general framework that combines the empirical likelihood and general estimation equations with nuisance parameters for the joint inferences of sensitivity and specificity with missing diagnostic data. The proposed methods will have sound theoretical properties. The theoretical development is challenging because the proposed profile log-empirical likelihood ratio statistics are not the standard sum of independent random variables. The new methods have the power of likelihood based approaches and jackknife method in ROC studies. Therefore, they are expected to be more robust, more accurate and less computationally intensive than existing methods in the evaluation of competing diagnostic tests.

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10

Wang, Zhuoyu. "Bias from a missing covariate in the analysis of diagnostic test data in the absence of a gold-standard." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=119705.

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Covariates that influence the sensitivity and/or specificity of different diagnostic tests can create correlations between these tests, conditional on disease status. Thus, ignoring such covariates in a latent class analysis of imperfect tests would amount to ignoring conditional dependence, potentially leading to biased estimates of the prevalence of the condition under study and the accuracies of the tests. In the case of a dichotomous covariate affecting two imperfect tests, we derive an expression showing that the conditional covariance is a function of the product of the change in test sensitivity (or specificity) within subgroups defined by the covariate. For a uniformly or normally distributed continuous covariate, similar results are obtained numerically. Using series of simulated datasets, we study whether in the absence of covariate, unbiased estimates may be obtained by fitting a latent class model that allows for conditional dependence. We found that bias induced by ignoring the dependence and using a conditional independence model is not large in most cases. In cases where bias is present, a conditional dependence model, which places no constraints on the covariance between the tests, works well in adjusting for all three types of missing covariates. Our methods are applied to diagnostic testing data for the detection of tuberculosis which varies by the covariate HIV status.
Les covariables qui influencent la sensibilité et/ou la spécificité des différents tests de diagnostic peuvent créer des corrélations entre ces tests, conditionnellement à l'état de la maladie. Ainsi, en ignorant ces variables dans une analyse de classe latente de tests imparfaits, on en reviendrait à ignorer la dépendance conditionnelle pouvant conduire à des estimations biaisées de la prévalence de la condition sous étude ainsi qu'à la précision des tests. Dans le cas d'une covariable dichotomique affectant deux essais imparfaits, nous dérivons une expression qui montre que la covariance conditionnelle est une fonction du produit de la variation de la sensibilité du test (ou de la spécificité) dans les sous-groupes définis par la covariable. Pour une covariable continue distribuée uniformément ou normalement des résultats similaires sont obtenus numériquement. En utilisant des séries de données simulées, nous étudions si, avec l'absence de covariable, des estimations impartiales peuvent être obtenues en ajustant un modèle de classe latente permettant la dépendance conditionnelle. Nous avons constaté, en ignorant la dépendance et en utilisant un modèle d'indépendance conditionnelle, que le biais induit n'est pas grand dans la plupart des cas. Dans les cas où le biais est présent, un modèle de dépendance conditionnelle qui n'impose pas de contraintes sur la covariance entre les tests fonctionne bien en ajustant tous les trois types de variables manquantes. Nos méthodes sont appliquées aux données des tests diagnostiques pour le dépistage de la tuberculose qui varient en fonction du statut de la covariable du VIH.

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11

Wollschläger, Rachel [Verfasser], and Franzis [Akademischer Betreuer] Preckel. "Diagnostic Competencies of Teachers: Accuracy of Judgment, Sources of Bias, and Consequences of (Mis-)Judgment / Rachel Wollschläger ; Betreuer: Franzis Preckel." Trier : Universität Trier, 2017. http://d-nb.info/1197703330/34.

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12

Aragon, Davi Casale. "Avaliação de métodos estatísticos aplicados ao estudo de testes diagnósticos na presença do viés de verificação." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/17/17139/tde-29022008-113040/.

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O estudo de métodos estatísticos na avaliação de métodos diagnósticos tem aumentado consideravelmente nas últimas décadas. Desde o início, quando Yerushalmy (1947) publicou seu traba lho sobre confiabilidade do roentgeno grama na identificação da tuberculose, novas metodologias surgiram para que fosse possível a obtenção de valores de sensibilidade e especificidade de testes diagnósticos. A sensibilidade é definida como a probabilidade de o teste sob investigação fornecer um resultado positivo, dado que o indivíduo é realmen te portador da enfermidade. A especifi cidade, por sua vez, é definida como a probabilidade de o teste fornecer um resultado negativo, dado que o indivíduo está livre da enfermidade. Na prática, é comum ocorrerem situações em que uma proporção de indivíduos selecionados não pode ter o estado real da doença verificado, por se tratar de procedimentos invasivos, como no diagnóstico de câncer de pulmão, ou quaisquer outros casos em que são envolvidos riscos, portanto não praticá veis, nem éticos, ou ainda por serem de alto custo. Assim, em vez de se contornar o proble ma, muitos estudos de avaliação de performance de testes diagnósticos são elaborados apenas com informações de indivíduos verificados. Esse procedimento pode levar a resultados viesados. É o chamado viés de verificação, que consiste no cálculo de estimativas de sensibilidade e especi ficidade de testes diagnósticos quando apenas os indivíduos verificados pelo padrão ouro são inseridos na análise e os não verificados são descartados ou considerados livres de doença. Este trabalho apresenta uma revisão das metodologias já propostas para se calcularem a sensibilidade e a especificidade quando existe o viés de verificação, bem como uma análise detalhada da influência da proporção de indivíduos não verificados, o efeito do tamanho amostral e a escolha de distri buições a priori, quando utilizada a metodologia bayesiana, no cálculo dessas estimativas. Também foi introduzida uma metodologia, sob enfoque bayesiano, para a estimação das medidas de desempenho de dois testes diagnósticos, na presen ça do viés de verificação.
The study of statistical methods on diagnostic tests evaluation has increa sed in the last decades. Since the beginning, when Yerushalmy (1947) published his work about trustwor thiness of the roentgenogram in the identification of the tuberculosis, new methodologies had appeared and so that it was possible to get values of sensi tivity and specificity of diagnostic tests. Sensitivity is defined as the probability of the test under inquiry supply a positive result, since that the individual is really carrying on the disease. The specificity, in the other hand, is defined as the probability of the test supply a negative result, since that the individual is free of the disease. In practice, it is usual to occur situations where a proportion of selected individuals cannot have verified the real state of the illness, to the fact that the verification test can be an invasive procedure, as in the diagnosis of lung cancer, or any other cases where risks are involved, therefore not practicable, nor ethical, or still procedures with high cost. Thus, instead of solve the problem, many studies of evaluation of performance of diagnostic tests are elaborated only using the information of verified individuals. This procedure can leads to biased results. This is known as verification bias, that consists of the calculation of estimates of sensitivity and specificity of diagnostic tests when only the individuals verified by the gold standard test are inserted in the analysis and the unverified ones, discarded or considered that they are free of the disease. This work presents a revision of the methodologies already proposed to calculate sensitivity and the specificity in the presence of the verifi cation bias, as well as a detailed analysis of the influence of the propor tion of individuals not verified, the effect of the sample size and the influ ence of choosing different prior densi ties, when using the bayesian methodo logy, in the calculation of these estima tes. It was also introduced a bayesian methodology to estimate performance measures of two diagnostic tests when the verification bias is present.

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13

Patureau-Hatchett, Micah. "Counselors' Perceptions of Training, Theoretical Orientation, Cultural and Gender Bias, and Use of the Diagnostic and Statistical Manual of Mental Disorders-IV-Text Revision." ScholarWorks@UNO, 2008. http://scholarworks.uno.edu/td/847.

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Counselor educators and counseling practitioners today reflect the future direction of the counseling profession; therefore, their opinions are important when discussing how professional counselors can reconcile the basic philosophies of humanistic counseling with the practical advantages and ethical and philosophical disadvantages that appear to be coexistent when discussing the diagnosis of clients and the Diagnostic and Statistical Manual of Mental Disorders IV-Text Revision (DSM). This study sought to provide a reflective and concise description of the current perceptions of licensed professional counselors in reference to their training, their practice, and their dispositions about diagnosis and utilization of the DSM despite its theoretical grounding in the medical model and its chronic problems with gender and cultural bias—all in direct opposition to counseling's humanistic, multicultural model of practice. Results of this study suggested that more training in DSM/diagnosis led to participants' higher perception of their ability to diagnose and utilize the DSM; however, participants' perceptions were split on whether or not training should include psychopharmacology. Results also suggested that LPCs most frequently occurring ethical dilemma in relation to diagnosis involved the reimbursement requirements of insurance/managed care companies; however, they strongly disagreed that diagnosing clients conflicted with their counseling professional identity. Participants strongly agreed that they were multiculturally competent; however, those participants who indicated that they diagnose using a multicultural or wellness perspective did not agree that the DSM does not adequately present disorders in such a way as to allow LPCs to diagnose culturally diverse and female clients accurately.

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14

McKibben, Jodi B. Aronoff. "Sex and Cult Affiliation Biases in the Diagnosis of Dependent and Narcissistic Personality Disorders: An Empirical Investigation." Ohio : Ohio University, 2003. http://www.ohiolink.edu/etd/view.cgi?ohiou1057177965.

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15

Launay, Elise. "Méthodologies d’évaluation de l’optimalité des soins : exemples des délais diagnostiques et des infections bactériennes sévères de l’enfant." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCB134/document.

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Les objectifs de cette thèse étaient de produire des connaissances nouvelles sur les méthodologies d’évaluation de l’optimalité des soins avec l’exemple des délais diagnostiques et des infections bactériennes sévères de l’enfant (IBS). Nous avons mis en évidence, dans deux revues systématiques de la littérature, que les points méthodologiques potentiellement associés à des risques de biais et d’obstacles à la transportabilité des résultats étaient rarement rapportés dans les études primaires sur les délais diagnostiques ou rarement évalués par les auteurs de méta-analyses. Nous avons donc construit et validé internationalement une reporting guideline pour aider les scientifiques à prendre en compte ces points méthodologiques critiques. Nous avons montré par une enquête confidentielle avec comité d’experts en population que : (i) les prises en charge étaient suboptimales pour 76% des enfants décédés d’IBS, (ii) un retard au recours médical, une sous-évaluation de la gravité ou un retard à l’antibiothérapie étaient retrouvés dans la prise en charge de respectivement 20%, 20% et 24% des enfants atteints d’IBS, (iii) les soins suboptimaux étaient indépendamment et fortement associés au risque de décès et (iv) les soins suboptimaux étaient plus fréquents chez les enfants de moins d’un an ou lorsque qu’ils n’étaient pas administrés par un médecin spécifiquement formé. La minimisation des biais dans la sélection des participants et la mesure de l’optimalité et la prise en compte de facteurs de confusion comme la sévérité intrinsèque de la maladie sont des éléments clefs de l’évaluation de l’optimalité des soins afin de produire des messages cliniques correctifs valides
The aim of this thesis was to product new knowledge about the methodology on how to assess the optimality of care with the examples of time to diagnosis and serious bacterial infection (SBI). In two systematic reviews, we found that the key methodological points potentially related to risks of bias or threats to transportability were rarely reported in the primary studies and rarely evaluated by authors of systematic reviews. Then, we developed and internationally validated a reporting guideline to help scientists to better take into consideration these critical methodological points. In a population-based confidential inquiry, we found that: (i) care was suboptimal in 76% of the initial management of children who died from SBI, (ii) delayed first medical contact, undervaluation of severity or delayed antibiotic administration were detected in the management of 20%, 20% and 24% of children admitted to intensive care for a SBI, respectively, (iii) the total number of suboptimal cares delivered during the management was independently associated with death, and (iv) suboptimal cares were more frequent in children younger than one year old and if the care was delivered by a non specialist physician. Minimizing the risks of bias both in the selection process of the study population and in the assessment of the optimality of care, and taking into account confounding factors such as the intrinsic severity of the disease are keys elements to ensure a reliable evaluation of optimality of care in order to produce effective corrective clinical messages

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Mourad, Abbas. "Modélisation de la morbi-mortalité du carcinome hépatocellulaire en France par stade de gravité : évaluation de différentes stratégies en fonction du dépistage et des ressources thérapeutiques." Phd thesis, Université du Droit et de la Santé - Lille II, 2014. http://tel.archives-ouvertes.fr/tel-00989711.

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Le CHC est souvent diagnostiqué à un stade avancé, stade où les options thérapeutiques sont limitées et le plus souvent palliatives. A l'inverse, les patients diagnostiqués à un stade précoce sont candidats à des traitements curatifs tels que la résection chirurgicale, la radiofréquence et la transplantation hépatique. Le dépistage par échographie des cirrhotiques (surveillance tous les 6 mois) est recommandé par la grande majorité d'experts et les sociétés savantes afin de détecter et traiter le CHC à un stade précoce. Cependant, l'impact du dépistage sur la survie des patients reste controversé en raison des insuffisances méthodologiques des études l'ayant évalué. Parmi les incertitudes méthodologiques, le biais d'avance au diagnostic, qui correspond à un allongement du temps de suivi du à un dépistage plus précoce, n'a le plus souvent pas été pris en compte dans les études ayant évalué l'impact du dépistage. L'approche par modélisation est une option attractive pour l'évaluation du dépistage car la réalisation d'un essai randomisé contrôlé comparant les malades dépistés et non dépistés est irréalisable pour des raisons d'ordre éthique. Dans ce travail, nous avons développé un modèle de la progression du CHC de la date de diagnostic jusqu'au décès. Ce modèle prend en compte l'âge des patients, la connaissance du statut VHC et les principaux facteurs pronostiques du CHC sur cirrhose virale C compensée et décompensée. Il a été alimenté par plusieurs types de données pour fixer les probabilités de transitions dans le modèle, et valider les sorties du modèle. Dans un premier temps, afin d'éviter une surestimation du bénéfice du dépistage, il a été indispensable de calculer le biais d'avance au diagnostic et de l'intégrer dans le calcul de la survie des patients dépistés. Dans un deuxième temps le modèle a évalué l'impact du dépistage du CHC chez les patients ayant une cirrhose virale C compensée et connaissant leur statut VHC. Dans un contexte de cirrhose compensée avec un statut VHC-connu, notre étude montre que le dépistage du CHC réalisé dans la pratique courante (taux d'accès au dépistage = 57%, une efficacité du dépistage correspondant à 42% des patients diagnostiqués à un stade précoce) améliore la survie des patients, avec une augmentation de l'espérance de vie (EV) de 11 mois et une diminution de risque de décès à 5 ans de 6% par rapport à l'absence du dépistage (taux d'accès au dépistage = 0%, 19% des patients non dépistés pour le CHC sont diagnostiqués à un stade précoce). Elle souligne l'importance des deux variables, taux d'accès au dépistage et efficacité du dépistage, sur la survie des patients. Par rapport au dépistage réalisé dans la pratique courante : a) un scénario d'augmentation du taux d'accès au dépistage de 57% à 97% augmente l'EV de 7 mois et diminue le risque de décès à 5 ans de 5% ; b) un scénario d'augmentation de l'efficacité du dépistage de 42% à 87% (dépistage optimal) augmente l'EV de 14 mois et diminue le risque de décès à 5 ans de 9% ; c) un scénario combinant une augmentation de l'efficacité du dépistage à 87% et une augmentation du taux d'accès au dépistage à 97% augmente l'EV de 31 mois et diminue le risque de décès à 5 ans de 20%. Cette étude souligne la nécessité d'une application stricte des modalités de dépistage du CHC, afin d'optimiser son efficacité à diagnostiquer le CHC au stade précoce. Ce travail suggère que les experts devraient cibler leurs recommandations sur l'efficacité du dépistage. De telles recommandations pourraient conduire à discuter de l'expérience et de la qualification des opérateurs et de la qualité du parc des échographes utilisés pour homogénéiser la qualité du dépistage. Finalement, nous avons observé dans un travail préliminaire que le choix optimal de la méthode de correction pour le calcul du biais d'avance au diagnostic devrait prendre en compte la progression tumorale d'un stade asymptomatique vers un stade symptomatique qui diffère d'un cancer à l'autre.

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Lee, Amanda Pui Shan. "Fault diagnosis in the presence of sensor bias." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270675.

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18

Berglof, Hollie K. "Differential Diagnosis of Attention Deficit Hyperactivity Disorder and Depression: Potential Bias and Misdiagnosis." DigitalCommons@USU, 2003. https://digitalcommons.usu.edu/etd/6189.

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This study investigated whether psychologists are attempting to distinguish between attention deficit hyperactivity disorder (ADHD) and depression in youth. Findings indicate that, overall, clinicians are conducting comprehensive evaluations and considering ADHD and depression as likely diagnoses. Clinicians were more likely to use self-report depression measures if the client was female or adolescent than if the child was male or school age; however, they were equally likely to incorporate ADHD-related measures with males and females , and 8 year olds and 15 year olds . Clinicians were more likely to consider adolescents than school-age children and females than males to have a mood disorder. Doctoral-level clinicians were more likely to consider a mood disorder and ADHD than master's- level clinicians. Clinicians who had completed a child psychopathology course were more likely to consider ADHD than those who had not completed such a course. The implications of these findings for child-oriented clinicians are discussed.

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McNally, Kelly A. "Application of Signal Detection Theory to Verbal Memory Testing for the Differential Diagnosis of Psychogenic Nonepileptic and Epileptic Seizures." University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1178883120.

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Leung, Kwok-keung, and 梁國強. "The neural basis of attention bias toward mood-congruent information in people with major depressive disorder." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B40203736.

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Hartman, Jennifer S. "ARE CLINICIANS BIASED? THE ROLE OF CLIENT VARIABLES IN CLINICIAN ASSESSMENT AND DIAGNOSIS OF DEPRESSIVE DISORDERS." University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin998321388.

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Brown, Oliver. "Novel dissymmetric copper bis(thiosemicarbazone) complexes for medical diagnostic imaging by positron emission tomography." Thesis, University of Kent, 2015. https://kar.kent.ac.uk/53590/.

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Bis(thiosemicarbazone) ligand derivatives and their metal complexes have long been of interest as they have applications as anticonvulsants, super-oxide dismutase-like radical scavengers, in the investigation of Alzheimer’s disease and diagnostic imaging. Copper (II) bis(thiosemicarbazone) derivatives have been used extensively in the imaging of oxygen deficient (hypoxic) cells for the detection and imaging of cancerous tissues and heart disease via Positron Emission Tomography (PET). It is possible to fine tune the bis(thiosemicarbazone) complexes redox potentials and lipophilicity by altering the substituents on the Q1 and Q2 position and the R1, R2, R3 and R4 locations respectively. To date only symmetric bis(thiosemicarbazone) ligands (R1=R3, R2=R4) have been evaluated for hypoxia imaging. This thesis reports the synthesis of dissymmetric ligands (R1≠R3, R2≠R4) in order to gain further control of the properties of the complexes and therefore the locations they will migrate to. A range of ligands has also been synthesised for the monitoring of copper metabolism within the brain for the investigation of Alzheimer’s disease and other neurodegenerative disorders. Ligand synthesis has been achieved by controlling the condensation reactions between dicarbonyl compounds and 4-substituted-3-thiosemicarbazides. Synthesis via an alternative acetal protecting method has also been investigated. Thirty bis(thiosemicarbazone) ligands have been successfully synthesised, of which thirteen are symmetric and seventeen dissymmetric. From this library of ligands, eighteen copper complexes have been synthesised along with twenty zinc complexes. The zinc complexes have the potential to act as convenient precursors for the rapid synthesis of radio-copper complexes via a transmetalation method. All ligands, complexes and intermediates have been fully characterised by a range of techniques including IR spectroscopy, Raman spectroscopy, NMR spectroscopy, UV-vis spectroscopy, elemental analysis and mass spectroscopy. A new cyclic by-product from the ligand synthesis has also been isolated and fully characterised.

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23

Cox, Michelle, and shelleyjcox@hotmail com. "Attentional bias effects following trauma exposure comparison of emotional Stroop and emotional lexical decision task paradigms." Swinburne University of Technology, 2005. http://adt.lib.swin.edu.au./public/adt-VSWT20051130.132059.

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Attentional bias effects for threat and emotional words were investigated, using both the emotional Stroop and emotional lexical decision paradigms. Twenty-eight controls and twenty-eight survivors of sexual assault participated in this study, which comprised three key comparisons. First, key predictions of the threat and emotionality hypotheses were compared, in particular specific and general threat effects, and positive and negative emotionality effects. Second, two separate group comparisons were conducted, specifically controls versus survivors of sexual assault overall, and a matched subset of controls versus PTSD positive survivors of sexual assault versus PTSD negative survivors of sexual assault. Third, performance on the emotional Stroop task and emotional lexical decision task paradigms were compared directly. Slowed colour naming responses (i.e. interference) were observed for both threat effects and emotionality effects in the emotional Stroop task. For the emotional lexical decision task, slowed lexical decisions (i.e. interference) were observed for threat effects, whereas speeded lexical decisions (i.e. facilitation) were observed for emotionality effects. The findings of the current study indicate that threat and emotionality effects may co-exist in both control and survivor populations. The relationship between the presence or absence of PTSD symptoms and threat and emotionality effects requires further investigation with larger sample sizes. There may be a relationship between the presence of PTSD symptoms and specific threat effects, however the findings of the current study for general threat information were inconclusive. No relationship was evident between the presence of absence of PTSD symptoms and positive or negative emotionality effects. The current findings suggest that the emotional Stroop task may be better suited to quantifying threat effects but not emotionality effects, whereas the emotional lexical decision task appears to be able to quantify both threat and emotionality effects.

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Nishikawa, Haruo. "Influence of verification bias on the assessment of MRI in the diagnosis of meniscus and cruciate ligament tears." Kyoto University, 2014. http://hdl.handle.net/2433/189636.

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Martienssen, Nora Milena [Verfasser]. "Validierte Diagnostik von 6- bis 8-jährigen Kindern mit spezifischer Sprachentwicklungsstörung / Nora Milena Martienssen." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2011. http://d-nb.info/1026069009/34.

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SILVA, Priscila Gonçalves da. "Inferência e diagnóstico em modelos não lineares Log-Gama generalizados." Universidade Federal de Pernambuco, 2016. https://repositorio.ufpe.br/handle/123456789/18637.

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Submitted by Fabio Sobreira Campos da Costa (fabio.sobreira@ufpe.br) on 2017-04-25T14:46:06Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) TESE VERSÃO FINAL (CD).pdf: 688894 bytes, checksum: fc5c0291423dc50d4989c1c2d8d4af65 (MD5)
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Young e Bakir (1987) propôs a classe de Modelos Lineares Log-Gama Generalizados (MLLGG) para analisar dados de sobrevivência. No nosso trabalho, estendemos a classe de modelos propostapor Young e Bakir (1987) permitindo uma estrutura não linear para os parâmetros de regressão. A nova classe de modelos é denominada como Modelos Não Lineares Log-Gama Generalizados (MNLLGG). Com o objetivo de obter a correção de viés de segunda ordem dos estimadores de máxima verossimilhança (EMV) na classe dos MNLLGG, desenvolvemos uma expressão matricial fechada para o estimador de viés de Cox e Snell (1968). Analisamos, via simulação de Monte Carlo, os desempenhos dos EMV e suas versões corrigidas via Cox e Snell (1968) e através da metodologia bootstrap (Efron, 1979). Propomos também resíduos e técnicas de diagnóstico para os MNLLGG, tais como: alavancagem generalizada, influência local e influência global. Obtivemos, em forma matricial, uma expressão para o fator de correção de Bartlett à estatística da razão de verossimilhanças nesta classe de modelos e desenvolvemos estudos de simulação para avaliar e comparar numericamente o desempenho dos testes da razão de verossimilhanças e suas versões corrigidas em relação ao tamanho e poder em amostras finitas. Além disso, derivamos expressões matriciais para os fatores de correção tipo-Bartlett às estatísticas escore e gradiente. Estudos de simulação foram feitos para avaliar o desempenho dos testes escore, gradiente e suas versões corrigidas no que tange ao tamanho e poder em amostras finitas.
Young e Bakir (1987) proposed the class of generalized log-gamma linear regression models (GLGLM) to analyze survival data. In our work, we extended the class of models proposed by Young e Bakir (1987) considering a nonlinear structure for the regression parameters. The new class of models is called generalized log-gamma nonlinear regression models (GLGNLM). We also propose matrix formula for the second-order bias of the maximum likelihood estimate of the regression parameter vector in the GLGNLM class. We use the results by Cox and Snell (1968) and bootstrap technique [Efron (1979)] to obtain the bias-corrected maximum likelihood estimate. Residuals and diagnostic techniques were proposed for the GLGNLM, such as generalized leverage, local and global influence. An general matrix notation was obtained for the Bartlett correction factor to the likelihood ratio statistic in this class of models. Simulation studies were developed to evaluate and compare numerically the performance of likelihood ratio tests and their corrected versions regarding size and power in finite samples. Furthermore, general matrix expressions were obtained for the Bartlett-type correction factor for the score and gradient statistics. Simulation studies were conducted to evaluate the performance of the score and gradient tests with their corrected versions regarding to the size and power in finite samples.

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Heltshe, Sonya Lenore. "Quantification of length-bias in screening trials with covariate-dependent test sensitivity /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.

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Thesis (Ph.D. in Biostatistics, Department of Preventive Medicine and Biometrics) -- University of Colorado Denver, 2007.
Typescript. Includes bibliographical references (leaves 89-93). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;

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Soliday, Sharon Elise. "Cultural Bias in the Assessment of Phonological Processes in Conjunction with the APP-R." PDXScholar, 1993. https://pdxscholar.library.pdx.edu/open_access_etds/4671.

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Normal phonological development is characterized by phonological processes in preschool children. These processes are sound error patterns, in relation to the adult target, that are expected within the speech of normally developing children. As children grow older, they "outgrow" these developmental errors. Within the black English dialect, speakers may use a combination of these processes and not be considered phonologically impaired within their linguistic community. The purpose of this study was to assess and compare phonological process usage in the speech of lower socioeconomic black and white preschoolers. The APP-R in conjunction with the CAPP was administered to two groups of 15 children to determine if significant differences exist in the usage of phonological processes between the two groups. Group 1 was comprised of 15 black preschoolers from an inner-city preschool program. Group 2 was comprised of 15 white preschoolers from a Headstart program. All children were identified by their respective speech-language pathologist as having normally developing speech for their linguistic community. Data analysis revealed black preschoolers used phonological processes with a higher frequency than white preschoolers. The phonological process usage mean for the black preschoolers was 4.26% (SD = 1.94) and the mean for the white preschoolers was 1.71% (SD = 2.86). Three of the ten basic processes were determined to be significantly different between the two groups, including: consonant sequence omission, strident deviation, and velar deviation. The results were further examined to determine if either group of preschoolers was identified as needing phonological remediation based on their performance on the APP-R. None of the subjects in either group was identified as needing phonological remediation. In conclusion, results indicated black English speaking preschoolers did use significantly more phonological processes in their speech, however, the APP-R did not identify these children as needing phonological remediation. These results demonstrate the APP-R to be an appropriate assessment tool when evaluating the speech of this Portland black English speaking sample.

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Randerath, Jennifer. "Aspekte des Werkzeuggebrauchs: vom Greifen bis zur Ausführung behaviorale und neuronale Korrelate der Apraxie." Tönning Lübeck Marburg Der Andere Verl, 2009. http://d-nb.info/999241958/04.

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Özokyay, Levent. "2- bis 4-Jahres-Ergebnisse zementfreier Pressfit-Pfannen bei Hüfttotalendoprothesen mit digitaler Migrationsvermessung mittels DiagnostiX 2048." [S.l.] : [s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=961114266.

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Leyrat, Clémence. "Biais de sélection dans les essais en clusters : intérêt d'une approche de type score de propension pour le diagnostic et l'analyse statistique." Paris 7, 2014. http://www.theses.fr/2014PA077064.

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L'objectif de ce travail est d'étudier l'intérêt des approches reposant sur le score de propension (SP) dans le contexte des essais en clusters (ERC) avec biais de sélection. Dans un premier temps, nous avons étudié à l'aide de simulations Monte Carlo, les performances de 4 méthodes reposant sur le SP (ajustement direct, pondération inverse, stratification et appariement) en comparaison à une régression multivariée classique pour l'analyse d'ERC avec biais de sélection. Lorsque le critère de jugement est continu, la régression multivariée et les méthodes reposant sur le SP (sauf l'appariement) corrigent le biais. En revanche, seul l'ajustement sur le SP permet d'estimer un effet non biaisé du traitement lorsqu'il s'agit d'un critère de jugement binaire de faible incidence. Dans un second temps, nous avons développé un outil de détection du biais de sélection, reposant sur la statistique c associée à un modèle de régression logistique. Cet outil fournit, pour un nombre de covariables et un effectif total fixés, une valeur seuil au-delà de laquelle on pourra conclure à la présence d'un biais de sélection. Ce travail soulève également les difficultés de la mise en place des méthodes de SP dans les ERC, liées à la structure hiérarchique des données, ainsi que les enjeux associés au choix de la méthode d'analyse dans un cadre d'inférence causale
This work aimed to study propensity score (PS)-based approaches for analysis of results of cluster randomized trials (CRTs) with selection bias. First, we used Monte Carlo simulations to compare the performance of 4 PS-based methods (direct adjustment, inverse weighting, stratification and matching) and classical multivariable regression when analyzing results of a CRT with selection bias. For continuous outcomes, both multivariable regression and PS-based methods (except matching) removed the bias. Conversely, only direct adjustment on PS provided an unbiased estimate of treatment effect for a low-incidence binary outcome. Second, we developed a tool for detecting selection bias that relies on the area under the receiver operating characteristic curve of the PS model. This tool provides, for a fixed number of covariates and sample size, a threshold value beyond which one could consider the existence of selection bias. This work also highlights the complexity of implementing PS-based methods in the context of CRTs because of the hierarchical structure of the data, as well as the challenges linked to the choice of the statistical method in a causal inference framework

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Macht, Anna. "Pränatale FISH-Diagnostik am Institut für Humangenetik der Universität Würzburg im Zeitraum von 01/1998 bis 08/1999." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=969626347.

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Coroneo, Sabrina [Verfasser], and Axel [Akademischer Betreuer] Buchter. "Berufsbedingte Atemwegserkrankungen : Studie zur Prävalenz, Diagnostik bis hin zur Erfassung von Expositionsprofilen und Risikoberufen / Sabrina Coroneo. Betreuer: Axel Buchter." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2011. http://d-nb.info/105143453X/34.

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Edmed, Shannon L. "The influence of psychosocial factors on expectations and persistent symptom report after mild traumatic brain injury." Thesis, Queensland University of Technology, 2014. https://eprints.qut.edu.au/78670/6/Shannon_Edmed_Thesis.pdf.

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This thesis examines how psychosocial factors influence the report of persistent symptoms after mild traumatic brain injury. Using quasi-experimental methods, the research program demonstrates how factors unrelated to trauma-induced physiological brain damage can contribute to persistent symptoms after a mild traumatic brain injury. The results of this thesis highlight the possibility that outcome from mild traumatic brain injury could be improved by targeting psychosocial factors.

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Ströbele, Hannah [Verfasser], H. M. [Gutachter] Straßburg, and W. [Gutachter] Schneider. "Neuropsychologische Diagnostik bei sehr und extrem Frühgeborenen im Alter von sechs bis acht Jahren – eine Pilotstudie mit der WUEP-KD (Würzburger Psychologische Kurz-Diagnostik) / Hannah Ströbele. Gutachter: H.-M. Straßburg ; W. Schneider." Würzburg : Universität Würzburg, 2016. http://d-nb.info/111178437X/34.

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Kademann, Stefanie. "Was wird aus late talkers? neuropsychologische Untersuchungen im Quer- und Längsschnitt von früher Kindheit bis Kindergartenalter." München Verl. Dr. Hut, 2009. http://d-nb.info/994105533/04.

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Parent, Nathalie. "Analyse des biais de méthode associés à l'utilisation des échelle d'évaluation du comportement des enfants d'âge primaire." Doctoral thesis, Université Laval, 2007. http://hdl.handle.net/20.500.11794/19175.

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Krause, Gérard. "Wirksamkeit der Basisgesundheitsversorgung in Entwicklungsländern von der Diagnostik über die Therapieverordnung und Arzneimittelverfügbarkeit bis zur Patientencompliance am Beispiel von Burkina Faso /." [S.l.] : [s.n.], 2004. http://www.diss.fu-berlin.de/2005/154/index.html.

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Moro, Bruna Lorena Pereira. "A experiência de cárie da criança influencia o desempenho dos examinadores na detecção de lesões proximais de cárie em dentes decíduos?" Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/23/23132/tde-07062017-152253/.

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Apesar de muitos estudos terem sido realizados para avaliar a acurácia dos métodos de detecção de cárie, poucos avaliam possíveis fatores capazes de influenciar o desempenho dos examinadores, como por exemplo, a experiência de cárie da criança. Dessa forma, este estudo teve como objetivo avaliar se a experiência de cárie da criança influencia o desempenho do exame visual e radiográfico na detecção de lesões de cárie proximais em molares decíduos. A amostra foi composta por 80 crianças de 3 a 6 anos de idade, as quais foram classificadas de acordo com a experiência passada de cárie, considerando lesões cavitadas. Dois examinadores calibrados avaliaram 526 superfícies proximais. Inicialmente foi realizado o exame visual, e em seguida, o exame radiográfico. Como padrão de referência, outros dois examinadores realizaram o exame visual direto das superfícies após separação temporária com elástico ortodôntico. A sensibilidade, especificidade e acurácia dos métodos visual e radiográfico, isolados e em associação, foram calculadas e comparadas entre si considerando os limiares de lesões não cavitadas e de lesões cavitadas. Análises de regressão de multinível de Poisson foram utilizadas para avaliar a influência da experiência de cárie e de outras variáveis na performance das estratégias de diagnóstico. Análises estratificadas pela experiência de cárie da criança também foram conduzidas. A associação do exame radiográfico ao exame visual não melhorou a acurácia na detecção de lesões proximais de cárie em dentes decíduos nos dois limiares de um modo geral. No entanto, foi observada uma influência da experiência de cárie apenas no exame visual. A detecção de lesões não cavitadas em crianças com maior experiência de cárie foi superestimada, provavelmente devido a um viés de confirmação. Já para lesões cavitadas, a detecção pelo exame visual foi subestimada, indicando um possível viés de representatividade. Já o exame radiográfico não sofreu influência de vieses cognitivos, e a performance desse método isolado ou associado ao visual de forma simultânea foi melhor nas crianças com maior experiência de cárie. Portanto, conclui-se que a experiência de cárie da criança influencia o desempenho dos examinadores ao utilizar o exame visual na detecção de lesões proximais de cárie em dentes decíduos.
Despite many studies have already been conducted to investigate the accuracy of caries detection methods, few investigations have evaluated the influence of some factors on the examiners\' performance, such as child\'s caries experience. Thus, this study aimed to evaluate if the child\'s caries experience exerts some influence on the performance of visual and radiographic methods for the detection of approximal caries lesions in primary molars. Eighty children aged from 3 to 6 years were selected and classified according to the past caries experience considering cavitated lesions. Two calibrated examiners evaluated 526 approximal surfaces for the presence of caries lesions using visual inspection and radiographic methods. As reference standard, two other examiners checked the surfaces by direct visual inspection after the temporary separation with orthodontic rubbers. Sensitivity, specificity, and accuracy obtained with visual inspection and radiographic method, alone or associated, were calculated and compared considering non-cavitated and cavitated lesions thresholds. Poisson multilevel regression analyses were conducted to evaluate the influence of the caries experience on the performance of diagnostic strategies. Radiographic examination and visual inspection performed associated did not improve the accuracy in detecting approximal caries lesions in both thresholds. However, an influence of child\'s caries experience was observe only on the visual inspection. The detection of non-cavitated caries lesions in children with higher caries experience was overestimated, probably due to confirmation bias. On the other hand, considering cavitated caries lesions, the performance of visual inspection was underestimated, indicating the occurrence of representativeness bias. Nevertheless, the radiographic method did not suffer influence of any type of cognitive bias, and the performance of this method, alone or simultaneously associated with visual inspection, was better in children with higher caries experience. In conclusion, the child\'s caries experience exerts influence on visual inspection in detecting approximal caries lesions in primary teeth.

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Price, Sarah Jane. "What are we missing by ignoring text records in the Clinical Practice Research Datalink? : using three symptoms of cancer as examples to estimate the extent of data in text format that is hidden to research." Thesis, University of Exeter, 2016. http://hdl.handle.net/10871/21692.

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Electronic medical record databases (e.g. the Clinical Practice Research Datalink, CPRD) are increasingly used in epidemiological research. The CPRD has two formats of data: coded, which is the sole format used in almost all research; and free-text (or ‘hidden’), which may contain much clinical information but is generally unavailable to researchers. This thesis examines the ramifications of omitting free-text records from research. Cases with bladder (n=4,915) or pancreatic (n=3,635) cancer were matched to controls (n=21,718, bladder; n=16,459, pancreas) on age, sex and GP practice. Coded and text-only records of attendance for haematuria, jaundice and abdominal pain in the year before cancer diagnosis were identified. The number of patients whose entire attendance record for a symptom/sign existed solely in the text was quantified. Associations between recording method (coded or text-only) and case/control status were estimated (χ2 test). For each symptom/sign, the positive predictive value (PPV, Bayes' Theorem) and odds ratio (OR, conditional logistic regression) for cancer were estimated before and after supplementation with text-only records. Text-only recording was considerable, with 7,951/20,958 (37%) of symptom records being in that format. For individual patients, text-only recording was more likely in controls (140/336=42%) than cases (556/3,147=18%) for visible haematuria in bladder cancer (χ2 test, p<0.001), and for jaundice (21/31=67% vs 463/1,565=30%, p<0.0001) and abdominal pain (323/1,126=29% vs 397/1,789=22%, p<0.001) in pancreatic cancer. Adding text records reduced PPVs of visible haematuria for bladder cancer from 4.0% (95% CI: 3.5–4.6%) to 2.9% (2.6–3.2%) and of jaundice for pancreatic cancer from 12.8% (7.3–21.6%) to 6.3% (4.5–8.7%). Coded records suggested that non-visible haematuria occurred in 127/4,915 (2.6%) cases, a figure below that generally used for study. Supplementation with text-only records increased this to 312/4,915 (6.4%), permitting the first estimation of its OR (28.0, 95% CI: 20.7–37.9, p<0.0001) and PPV (1.60%, 1.22–2.10%, p<0.0001) for bladder cancer. The results suggest that GPs make strong clinical judgements about the probable significance of symptoms – preferentially coding clinical features they consider significant to a diagnosis, while using text to record those that they think are not.

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Schwabe, Kerstin [Verfasser]. "Beckenringfrakturen Typ C : Was hat sich in den Jahren 2004 bis 2014 epidemiologisch, diagnostisch und therapeutisch verändert? / Kerstin Schwabe." Ulm : Universität Ulm, 2020. http://d-nb.info/1220358959/34.

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Perneczky, Robert Georg. "Kurze kognitive Tests Validierung dreier neuropsychologischer Werkzeuge in der Diagnostik der leichten kognitiven Beeinträchtigung und der leicht- bis mittelgradigen Demenz bei Alzheimer-Krankheit /." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972057870.

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Brengelmann, Saskia Dominique [Verfasser]. "Klinik und Diagnostik der Syphilis [[Elektronische Ressource]] : eine Untersuchung bei Patienten der Infektionsambulanz der Universität zu Köln 2004 bis 2008 / Saskia Dominique Brengelmann." Köln : Deutsche Zentralbibliothek für Medizin, 2012. http://d-nb.info/1019620145/34.

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44

Brand, Jannik [Verfasser]. "Präklinische Diagnostik und Therapie in einer Mobilen Stroke Unit zur Verkürzung der Zeit bis zur intravenösen Thrombolyse beim akuten ischämischen Schlaganfall / Jannik Brand." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2020. http://d-nb.info/1219507865/34.

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Uhler, Marcus [Verfasser], Stephan [Akademischer Betreuer] Knipping, Hans Wilhelm [Akademischer Betreuer] Pau, and Alexander [Akademischer Betreuer] Eckert. "Diagnostik und Therapie des Peritonsillarabszesses am Städtischen Klinikum Dessau von 2000 bis 2009 / Marcus Uhler. Betreuer: Stephan Knipping ; Hans Wilhelm Pau ; Alexander Eckert." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2014. http://d-nb.info/1049437810/34.

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Winkler, Annegret [Verfasser], Christoph [Akademischer Betreuer] Thomssen, Lars-Christian [Akademischer Betreuer] Horn, and Clemens [Akademischer Betreuer] Tempfer. "Monozentrische retrospektive Analyse zu Diagnostik und Therapie des Endometriumkarzinoms von 2000 bis 2009 / Annegret Winkler. Betreuer: Christoph Thomssen ; Lars-Christian Horn ; Clemens Tempfer." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2015. http://d-nb.info/1090786433/34.

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Enners, Lydia. "Diagnostik und Therapie der unteren gastrointestinalen Blutung unter besonderer Berücksichtigung des Krankengutes der Chirurgischen Klinik des Krankenhauses Duesseldorf-Gerresheim im Zeitraum vom 01.01.1987 bis 31.12.1994." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=966046226.

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Barth, Marie-Christin [Verfasser]. "Rezidivverhalten und -diagnostik des enoralen Plattenepithelkarzinoms, eine retrospektive Analyse aus der Mund-, Kiefer- und Gesichtschirurgie der Universitätsmedizin Mainz von 2000 bis 2015 / Marie-Christin Barth." Mainz : Universitätsbibliothek der Johannes Gutenberg-Universität Mainz, 2020. http://d-nb.info/1224810724/34.

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Babis, Ulrike. "Retrospektive Betrachtung der perkutanen Interventionen bei insuffizienten Hämodialyseshunts in den Jahren 1990 bis 2000 in der Klinik für Radiologische Diagnostik des Universitätsklinikums der RWTH Aachen /." Aachen : Shaker, 2004. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=013209882&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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50

Strauß, Simon [Verfasser]. "Ursachen, invasive Diagnostik und Outcome nach erfolgreicher präklinischer Reanimation : eine retrospektive Analyse der Daten des NEF-4205 in Berlin von 2007 bis 2012 / Simon Strauß." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1140761218/34.

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