Journal articles: 'Diabetic angiopathies'

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Zhuk, E. A. "The use of the HELPER device for determining infrared radiation of the skin in the diagnosis of diabetic angiopathies." Problems of Endocrinology 44, no. 2 (September 23, 2019): 10–12. http://dx.doi.org/10.14341/probl199844210-12.

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A HELPER device is offered for the early diagnosis and monitoring of patients with diabetic angiopathies. The device picks up the limb skin temperature gradient. The temperature gradient in the diabetics increases with the progress of diabetic angiopathies in comparison with normal subjects.

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Malkova, T. A. "Effect of hyperbaric oxygenation on liver function in diabetic patients." Kazan medical journal 66, no. 1 (February 15, 1985): 18–20. http://dx.doi.org/10.17816/kazmj60405.

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&NA;. "LY-333531 corrects diabetic angiopathies." Inpharma Weekly &NA;, no. 1038 (May 1996): 9. http://dx.doi.org/10.2165/00128413-199610380-00016.

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Bobyreva, L. E. "Free-radical oxidation, antioxidants, and diabetic angiopathies." Problems of Endocrinology 42, no. 6 (December 15, 1996): 14–20. http://dx.doi.org/10.14341/probl12052.

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The leading pathology in endocrinology is diabetes mellitus, which is characterized by a high incidence of disability and high mortality. According to the data of A. G. Mazovetsky, by 2000 compared with 1985, an increase in the number of patients with diabetes mellitus is expected to be 2.9 times. The frequency of vascular lesions in diabetes is 6891.3%. The results of D. Greene indicate that peripheral vascular damage in this group of patients is observed 30 times more often than in people of a similar age without diabetes mellitus. Free radical pathology. Recent studies of domestic and foreign authors indicate the important role of non-enzymatic free radical oxidation (FRO) of lipids in the pathogenesis of many chronic diseases of modern man. Before analyzing the role of free radical mechanisms in the pathogenesis of diabetes mellitus and diabetic angiopathies, it is necessary to briefly familiarize yourself with the general ideas about the nature of FRO lipids and their inhibition systems. Due to the spin properties of triplet oxygen, when it interacts with a pair of donor electrons, the probability of free radical formation is high. The one-electron form of reduced oxygen can be protonated НО2*(hydroperoxyl radical) and anionic О2- (superoxide radical).

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Petrik, G. G., and S. A. Pavlishchuk. "Metabolic and hemostatic characteristics of patients with type 2 diabetes mellitus differing in the severity of angiopathy." Problems of Endocrinology 56, no. 2 (April 15, 2010): 15–19. http://dx.doi.org/10.14341/probl201056215-19.

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The objective of the present study was to identify risk factors of developing vascular disorders in patients at different stages of type 2 diabetes mellitus (DM2) by comprehensive analysis of metabolic parameters, hemograms, thrombocytic and plasma hemostasis. The study involved 75 patients (22 men and 53 women of mean age 57,3±9,7 years) having angiopathies of different severity. The data obtained confirmed the presence of risk factors of vascular pathology in different phases of DM2. All the examined patients including those without angiopathies in the early period of diabetes showed triglyceridemia, cholesterolemia, enhanced platelet aggregation activity, and shortened activated partial thromboplastin time. Patients with diabetic nephropathy at the stage of microalbuminuria and with non-proliferative retinopathy were distinct from the remaining ones in that they had significantly higher blood alpha-2 globulin and fibrinogen levels. Diabetic patients with micro- and macrovascular problems were characterized by marked dysproteinemia and abnormal platelet disaggregation.

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Frolov, Denis V. "The Role of Physical Therapy in the Combined Treatment of Patients with Lower Extremities Diabetic Angiopathies." Bulletin of Rehabilitation Medicine 20, no. 2 (April 30, 2021): 80–87. http://dx.doi.org/10.38025/2078-1962-2021-20-2-80-87.

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One of the most disabling complications of diabetes mellitus is angiopathy of the lower extremities. Diabetic polyneuropathy and diabetic foot syndrome are closely associated with vascular complications of diabetes mellitus, which significantly aggravate the course of the disease and contribute to high mortality. Diabetic polyneuropathy and diabetic foot syndrome are closely associated with the diabetes mellitus vascular complications that significantly aggravate the course of the disease and contribute to high mortality. Despite the improvement in the results of pharmacotherapy of diabetes mellitus, the problem of treating its vascular complications is far from being solved. Traditionally, therapeutic physical training is used among the methods of non-drug treatment of diabetes mellitus and its complications. As a method of pathogenetic focus on many risk factors for the development of diabetes and its complications, physical therapy exercises contribute to the correction of the syndrome of hypodynamia, obesity, and muscle atrophy. At the same time, there is insufficient data on how exercise therapy affects the quality of life of patients, functional characteristics of walking and objective indicators of blood flow in the lower extremities. This review identifies the main approaches to the application, advantages and disadvantages of individual methods of therapeutic physical training in the correction of functional disorders in patients with lower extremities diabetic angiopathies. We can currently talk about the proven safety of the physical therapy use in patients with diabetic angiopathies. Meanwhile, the scientific data on the high efficiency of this method is still insufficient.

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Gonchar, М. G., Zh М. Vavrik, Ye I. Deltsova, and R. G. Zelenetsky. "Effect of hyperbaric oxygenation on microcirculation, oxygen budget, and acid base balance of patients with diabetic angiopathies of the lower limbs." Problems of Endocrinology 39, no. 2 (December 15, 1993): 11–13. http://dx.doi.org/10.14341/probl11943.

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These effects were studied in 52 patients with degrees III-IV diabetic angiopathies of the lower limbs. Microcirculation parameters were found changed in this patient population, this leading to disorders of the oxygen budget and development of metabolic acidosis. Development of destructive changes in the limb evidences failure of the compensatory adaptive mechanisms of microcirculation. Addition of hyperbaric oxygenation to multiple-modality treatment of patients with diabetic angiopathies was conducive to improvement of the blood rheology, of tissue saturation with oxygen, and to essential reduction of metabolic acidosis. The detected microcirculation disorders necessitate addition to the therapeutic complex of the drugs improving the biophysical characteristics of the blood.

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Anestiadi, V., Z. Anestiadi, and V. Anestiadis. "P35 EVALUATION OF DIABETIC ANGIOPATHIES BY DIGITAL THERMOGRAPHY." Atherosclerosis Supplements 11, no. 2 (June 2010): 24. http://dx.doi.org/10.1016/s1567-5688(10)70102-1.

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Bondar', I. A., and V. V. Klimontov. "Hyperhomocysteinemia: a risk factor for vascular complications of diabetes." Problems of Endocrinology 50, no. 2 (April 15, 2004): 24–29. http://dx.doi.org/10.14341/probl11390.

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Vascular complications are a leading cause of reduced quality and longer life of patients with diabetes mellitus (DM). The mechanisms of development of these complications are not fully disclosed. It is known that in not all cases the occurrence and progression of diabetic angiopathies can be explained by traditional risk factors, such as hyperglycemia, arterial hypertension, smoking or dyslipidemia. Therefore, the search for the missing links in the pathogenesis of angiopathy remains an extremely urgent task.

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Vartanian, Natalia L., Vitali I. Odin, Vladimir V. Zarubajev, Andrey A. Novik, Ella S. Pushkova, and Anna A. Sominina. "Islet cell antibodies and diabetic angiopathies in elderly diabetes type 2 patients." Diabetes Research and Clinical Practice 50 (September 2000): 131. http://dx.doi.org/10.1016/s0168-8227(00)81902-6.

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Shestakova, Marina V., and Anastasia S. Severina. "Vascular complications of diabetes mellitus worldwide and in Russia: The path of 100 years. A review." Terapevticheskii arkhiv 95, no. 12 (December 28, 2023): 1039–43. http://dx.doi.org/10.26442/00403660.2023.12.202498.

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With the discovery and introduction of insulin, the "palette" of life-threatening conditions for patients with diabetes mellitus has changed dramatically: from diabetic coma of the "pre-insulin era" to severe vascular complications in the modern period. The key risk factors for diabetic angiopathies in diabetes mellitus are poor glycemic control in combination with a long course of the disease. Over the past 30 years, there has been a downward trend in the incidence of late vascular complications of diabetes both worldwide and in Russia. In particular, the frequency of cardiovascular events (myocardial infarctions, strokes, amputations) decreased, and the incidence of several other complications, such as diabetic retinopathy and neuropathy, stabilized. However, the incidence of chronic kidney disease and chronic heart failure is still increasing. The Joslin Medal, awarded to patients over 50, 75 and even 80 years of life with diabetes, reflects success in the fight against this disease.

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Nesterov, A. P. "Diabetic involvement of the organ of vision." Problems of Endocrinology 43, no. 3 (September 18, 2019): 16–19. http://dx.doi.org/10.14341/probl10388.

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Diabetic involvements of the organ of vision may be divided into extraocular and ocular. The first group includes xanthelasma and eczemas of the eyelids, hordeolum, chalasion, blepharitis, acute and chronic conjunctivitis, conjunctival angiopathies, and pareses of the extraocular muscles. The second group in- cludes*iridal dystrophy, anterior uveitis, cataract, glaucoma, asteroid hyalosis, lipemia rctinalis, and diabetic retinopathy with its complications (hemophthalmia, detachment of the retina, and neovascu- lar glaucoma). Diabetic retinopathy is a late complication of diabetes mellitus. The author discusses the epidemiology of this condition, its pathophysiological and clinical features, classification, contribution of local factors to its pathogenesis, and possibilities of treatment and prevention of the disease. He emphasizes the leading role of optimal correction of carbohydrate metabolism as a means preventing diabetic retinopathy and of timely laser photocoagulation of the retina in its treatment.

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Frolov, Denis V., Evgeniy V. Kryukov, Marina Yu Gerasimenko, and Alexander G. Kulikov. "Combined physical therapy for diabetic angiopathy." Russian Journal of Physiotherapy, Balneology and Rehabilitation 19, no. 1 (October 23, 2020): 25–31. http://dx.doi.org/10.17816/1681-3456-2020-19-1-4.

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Background. The problem of diabetic angiopathy is characteristic of countries even with a high level of development of medicine. The high frequency of complications of diabetes with high biological and social significance determines the need for their correction. The purpose of the work was to increase the effectiveness of rehabilitation treatment for patients with diabetic angiopathy through the combined use of therapeutic exercises and functional electrical stimulation of the lower extremities. Methods. A prospective cohort study was conducted, in which 90 patients (63 men and 27 women) with an established diagnosis of type 2 diabetes took part. Results. It was found that the use of therapeutic gymnastics and training walking on a treadmill and functional neuroelectrostimulation of the lower extremities increase the motor capabilities of patients due to the analgesic effect, improved neurogenic control of vasoconstriction of arteriovenous anastomoses and increased capillary blood flow. Conclusion. Functional electrical stimulation method can be effectively used in physical therapy programs for patients with diabetic lower limb angiopathies at the inpatient and outpatient stages.

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Mogil’nitskaya, L. A. "Serum fibronectin content in the patients suffering from type 1 diabetes mellitus with microangiopathies since the childhood and in the subjects presenting with obesity." Problems of Endocrinology 61, no. 1 (February 15, 2015): 36–40. http://dx.doi.org/10.14341/probl201561136-40.

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Micro- and macroangiopathies are the main causes of disability and mortality among the patients suffering from diabetes mellitus. Endothelial dysfunction is the early and important condition preceding the development of diabetic angiopathies. The serum fibronectin content may be one of the markers of endothelial dysfunction. We have documented the enhanced serum fibronectin content in the patients suffering from type 1 diabetes mellitus with concomitant microangiopathies and in the subjects presenting with obesity. The rise in the serum fibronectin level correlated with the body mass index, parameters of carbohydrate and lipid metabolism. Alteration of these parameters discovered in the present study may be used as the markers of endothelial dysfunction associated with the above pathological conditions.

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EGUSA, Genshi, Junichiro OGAWA, Shinkuro KATAOKA, Seijiro KADO, Hitoshi HARA, and Michio YAMAKIDO. "The Effects of Antiplatelet Therapy on the Development of Diabetic Angiopathies." Journal of Japan Atherosclerosis Society 17, no. 4 (1989): 571–77. http://dx.doi.org/10.5551/jat1973.17.4_571.

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Simonenkov, A. P., and V. D. Fedorov. "Are diabetic and age-related angiopathies based on chronic serotonin insufficiency?" Bulletin of Experimental Biology and Medicine 123, no. 1 (January 1997): 90–95. http://dx.doi.org/10.1007/bf02764391.

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Matsuda, M., F. Kawasaki, K. Yamada, Y. Kanda, M. Saito, M. Eto, M. Matsuki, and K. Kaku. "Impact of adiposity and plasma adipocytokines on diabetic angiopathies in Japanese Type 2 diabetic subjects." Diabetic Medicine 21, no. 8 (August 2004): 881–88. http://dx.doi.org/10.1111/j.1464-5491.2004.01261.x.

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18

Tanzeela Khan, Naheed Khan, and Sajida Qureshi. "Arterial involvement of lower limbs in peripheral artery disease - the difference between diabetics and non-diabetics." Journal of the Pakistan Medical Association 74, no. 2 (February 11, 2024): S59—S62. http://dx.doi.org/10.47391/jpma-duhs-s12.

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Objective: To detect peripheral artery disease in diabetic and non-diabetic individuals. Method: The case-control study was conducted from October 2018 to September 2019 at Ruth K.M. Pfau Civil Hospital, Karachi, and comprised diagnosed diabetic patients with random blood sugar Greater than or Equal to 200mg/dl in group A, and healthy non-diabetic subjects in group B. Ankle brachial pressure index was measured and mean luminal diameters of lower limb arteries were compared using colour Doppler ultrasonography. Data was analysed using SPSS 21. Results:Of the 82 subjects, 41(50%) were in each of the 2 groups. The sample had 42(51.2%) males and 30(48.8%) females with overall mean age of 53.9±5.07 years (range 44-60 years). There was significant difference in the ankle brachial pressure index values between the groups (p=0.004). There was also a significant difference in the mean luminal diameters of distal arteries (p=0.001), while there was no significant difference in proximal arteries (p>0.05). Conclusion: The diabetics were more prone to developing peripheral arterial disease than nondiabetics. Key Words: Blood Glucose, Ankle, Arteries, Ultrasonography, Angiopathies.

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Lebedeva, Ye A. "Antioxidant systems of blood plasma in the pathogenesis of diabetic microangiopathies." Problems of Endocrinology 42, no. 5 (October 15, 1996): 10–12. http://dx.doi.org/10.14341/probl12080.

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The parameters of lipid peroxidation and enzymatic and low-molecular antioxidant systems of blood plasma were studied in 114 patients with insulin-dependent diabetes mellitus and 51 donors (control group). The activities of extracellular superoxide dismutase, catalase, concentrations of plasma selenium, the activity of red cell glutathione peroxidase, and the level of uric acid were measured. Oxidant stress was found to involve no changes of the enzymatic component of antiperoxide defense in patients both at the debut of the disease and with diabetic angiopathies. Evidently, the cell protection is performed not by the enzymatic, but by the low-molecular antioxidant system. The level of total antioxidant activity of the plasma is increased in newly diagnosed diabetes and normalizes by the time of formation of microangiopathies. The concentration of uric acid - one of the plasma antioxidants - is reliably decreased in comparison with the control, which may be significant in the pathogenesis of microangiopathies.

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20

Elalamy, Ismail, Tahar Chakroun, Francoise Robert, Chantal Lecrubier, Fabienne Elgrably, Meyer M. Samama, Grigoris T. Gerotziafas, and Mohamed T. Hatmi. "Circulating Platelet-Leukocyte Aggregates as a Marker of Microvascular Lesions in Diabetic Patients." Blood 106, no. 11 (November 16, 2005): 3965. http://dx.doi.org/10.1182/blood.v106.11.3965.3965.

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Abstract Introduction: Evolution of diabetes is associated with multiple disorders including metabolic, cellular and blood disturbances leading to various vascular complications (micro-and macro-angiopathies). Increased circulating levels of platelet-leukocyte aggregates (PLA) have been described in several thrombotic diseases. Material and Methods: In this study, we have evaluated the circulating PLA in diabetic patients and we have investigated whether they may be linked to the vascular complications currently occurring during diabetes evolution. Using flow cytometry assay, we have quantified PLA percentages in 65 diabetics (37 males/28 females, 57 ± 11 years old) including 20 patients with type I and 45 with type II diabetes, and 25 healthy subjects (15 males/10 females, 44 ± 9 years old). Labelling approach using specific monoclonal antibodies permitted us to identify platelet-polymorphonuclear aggregates (PPA) and platelet-monocyte aggregates (PMA). Results: We have observed a significant increase of PPA and PMA levels in diabetics (22 ± 12% and 45 ± 18%, respectively) compared to control subjects (7 ± 4% and 19 ± 10%, respectively). However, both PPA and PMA values were similar in the two types of diabetes and they were not correlated to the disease duration. Circulating PPA and PMA percentages were significantly enhanced in diabetics with vascular lesions (n=37; PPA: 24 ± 13%; PMA: 50 ± 18%) than in diabetics without vascular lesions (n=28; PPA: 18 ± 8%; PMA: 38 ± 15%). Patients with PPA > 18% and /or PMA > 38% had a more important vascular thrombotic damage (OR: 6; 95%; IC: 1.6; 23). The increased PMA circulating percentage seems to be more specific for micro-retinopathy occurrence (OR: 19, 95% IC: 2.3; 154). The rare patients with elevated PMA percentage and without vascular lesions have a shorter duration of diabetes (7 ± 5 years) than patients presenting retinopathy lesions (16 ± 11 years). Conclusion: Together our findings established a relationship between increased circulating PLA rate, particularly that of PMA, and the incidence of microvascular complications in diabetic patients. In addition, they reinforce the concept that pro-inflammatory cells are involved in diabetic retinopathy pathogenesis.

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Othman, Nashwa, Osama Gheith, Torki Al-Otaibi, Tarek Said, Medhat A. Halim, Nabil Elserwy, Ayman Maher Nagib, Fatma Mahmoud, Heba Abduo, and Mohamed Jahromi. "Effect of Structured Diabetes Education on Diabetic Angiopathies Among Kidney Transplant Recipients With Posttransplant Diabetes: Kuwait Experience." Experimental and Clinical Transplantation 20, Suppl 1 (March 2022): 46–54. http://dx.doi.org/10.6002/ect.mesot2021.o19.

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Chiu, Hsuan, Hui-Ju Tsai, Jiun-Chi Huang, Pei-Yu Wu, Wei-Hao Hsu, Mei-Yueh Lee, and Szu-Chia Chen. "Associations between Triglyceride-Glucose Index and Micro- and Macro-Angiopathies in Type 2 Diabetes Mellitus." Nutrients 12, no. 2 (January 26, 2020): 328. http://dx.doi.org/10.3390/nu12020328.

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The aim of this study was to investigate the associations between the triglyceride-glucose (TyG) index, a marker of insulin resistance, and microangiopathies and macroangiopathies in patients with type 2 diabetes mellitus (DM). Our study enrolled 1990 type 2 diabetic patients from local hospitals in Taiwan during the period of 2002–2004. Multivariate logistic regression analysis was used to identify the factors related to microangiopathies, macroangiopathiess and TyG index. The patients were stratified by TyG index quartile (Q1–Q4). Adjusted odds ratios (aORs) of albuminuria for Q3 versus Q1 and Q4 versus Q1 were 1.424 (95% confidence interval [CI], 1.062–1.910, p = 0.018) and 1.948 (95% CI, 1.437–2.642, p < 0.001), respectively. The aOR of cerebrovascular disease (CVA) was 2.264 for Q4 versus Q1 (95% CI, 1.243–4.122, p = 0.008), but there were no significant associations with diabetic retinopathy (DR), coronary artery disease (CAD) or peripheral artery occlusive disease (PAOD). Significant stepwise increases were found in CVA (p = 0.0013) and albuminuria ≥30 mg/g (p < 0.001) corresponding to TyG index quartiles, but not DR (p = 0.573), CAD (p = 0.880) or PAOD (p = 0.223). There was a significant association between a high TyG index and a high risk of microalbuminuria and CVA in the study cohort. Further studies to investigate the use of medications in patients with DM to prevent micro- and macro-angiopathies are thus warranted.

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Mazurov, N. A. "Infusion of ozonized solutions in the treatment of diabetic angiopathies of lower extremities." Kazan medical journal 79, no. 4 (July 15, 1998): 262–63. http://dx.doi.org/10.17816/kazmj64415.

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For the application in surgical practice the treatment method of diabetic angiopathy of lower extremities is proposed involving the intravenous injection of ozonized solutions. The method proposed allowed to localize fast the pyo-necrotic process, to reduce the number of amputations, to decrease the terms of hospitalizations. The method is simple, it does not require special skills and is pathogenetically justified.

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Benedito Castellote, Sara. "The retina, a window of cerebrovascular disease in diabetes." Anales de la Real Academia Nacional de Farmacia 88, no. 88(01) (2022): 19–30. http://dx.doi.org/10.53519/analesranf.2022.88.01.01.

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Cerebrovascular disease is one of the complications of long-term diabetes mellitus. While the structure and function of the great cerebral vessels may be more easily studied, the cerebral microcirculation is difficult to assess. However, a simple eye fundus examination with an ophthalmoscope enables to visualize the microvascular abnormalities that characterize diabetic retinopathy, which isth e most common microvascular complication of diabetes. The anatomical and functional similarity between retinal and cerebral microcirculation supports the hypothesis that alterations in retinal vascular reactivity could be considered as an early marker of cerebral microvascular dysfunction in diabetes. The initiating factor of diabetic angiopathies is endothelial dysfunction. Endothelial dysfunction results in a reduced bioavailability of nitric oxide (NO), as a consequence of decreased NO synthesis and/or increased production of free oxygen radicals that are NO scavengers. Diabetes also stimulates the production of endothelial-derived contractile factors such as superoxide anions and hydroxyl radicals, endothelin and certain cyclooxygenase (COX) derivatives. COX activation is related to a high level of oxidative stress. Oxidative stress participates in the inflammatory response involved in the diabetic vascular dysfunction. These pathogenic mechanisms have been shown in both cerebral and retinal arteries, mainly through in vitro vascular reactivity studies, suggesting that diabetes induces a profound change in microvascular regulatory mechanisms. The association between the degree of retinal perfusion, brain injuries and altered cognitive function indicates a certain parallelism in the degree of impairment of both retinal and brain circulations. In addition, prospective studies conclude that diabetic retinopathy predicts ischemic cerebrovascular disease independently of other risk factors, supporting the importance of cerebral microvascular disease in diabetics. Further research on the vascular abnormalities is needed to understand the pathogenic mechanisms underlying retinopathies and cerebrovascular disease in diabetes. In the near future, the use of fully automated methods to detect signs of retinopathy will not only facilitate the efficient evaluation of vascular changes in the retina but will also help to reduce cerebral vascular morbidity and mortality.

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Chugunova, L. G., and I. I. Dubinina. "Lipid peroxidation parameters and activities of lysosomal enzymes in diabetics." Problems of Endocrinology 40, no. 5 (December 15, 1994): 9–11. http://dx.doi.org/10.14341/probl12156.

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The processes of lipid peroxidation and activities of lysosomal enzymes were studied in 56 patients with type I and II diabetes mellitus. The rate of lipid peroxidation of red cell membranes was assessed from the activities of enzymatic (NADPH-dependent) and nonenzymatic (ascorbate-dependent) . lipid peroxidation, from accumulation of acylhydroperoxides, in- termolecular joints, and from spontaneous red cell hemolysis. Activities of lysosomal enzymes (cathepsines, acid DNAse, and P-galactosidase) were measured in leukoconcentrate. The activity of enzymatic system of lipid peroxidation and acylhydroperoxide content in red cell membranes were found increased. In parallel with this, a deficiency in leukocytic lysosomes of P-galactosidase and DNAse was revealed. The detected metabolic disturbances may be regarded as one of the pathogenetic mechanisms of development of diabetic angiopathies. A relationship was revealed between changes in lipid peroxidation parameters and activities of lysosomal enzymes, on the one hand, and diabetes mellitus type and duration, on the other.

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Lyajfer, A. I., and M. N. Solun. "Lipid peroxidation system-antioxidant protection and the role of its disorders in the pathogenesis of diabetes mellitus and angiopathies." Problems of Endocrinology 39, no. 1 (February 15, 1993): 57–60. http://dx.doi.org/10.14341/probl11913.

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The urgency of the problem of diabetic angiopathies is highlighted by the fact that among patients with insulin-dependent diabetes mellitus under the age of 20 years mortality rate is 7 times higher than the average mortality among the General population, and after reaching 20 years, the average annual risk of mortality is 20 times higher than the total population. Recently, in the study of many pathological conditions, considerable attention has been paid to structurally functional changes in cell membranes. The severity and duration of membrane-damaging processes in the body determine the clinical severity and features of the course of many diseases. Membrane destruction as a pathological phenomenon is primarily due to the involvement of cell membrane lipids in lipid peroxidation processes, which leads to a change in lipid-protein bonds, the strength of the complex of enzymes and other membrane macromolecules, damage to nucleic acids, and impaired cellular metabolism.

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Kondratiev, Y. Yu, V. V. Nosikov, and I. I. Dedov. "Polymorphic genetic markers and vascular complications of diabetes." Problems of Endocrinology 44, no. 1 (February 1, 1998): 43–51. http://dx.doi.org/10.14341/probl199844143-51.

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Diabetes mellitus is a clinically and genetically heterogeneous disease characterized by absolute or relative insulin deficiency and (or) peripheral tissue resistance to the hormone. Each of these disorders individually or in various combinations reduces tissue glucose consumption and increases the concentration of this monosaccharide in the patient’s blood. The state of hyperglycemia is a necessary and, over time, sufficient condition for the development of the so-called late complications of diabetes mellitus (mainly vascular - diabetic angiopathies). These chronic complications of diabetes are the main cause of high disability and mortality in patients, thus representing not only a serious medical and social, but also an economic problem [60]. This problem is exacerbated by the fact that recently there has been a tendency to an increase in the incidence of diabetes [42], the expected prevalence of which by 2010 will be about 215 million people [59]. In addition, the most common form of the disease, non-insulin-dependent (type II) diabetes mellitus (NIDDM), is characterized by delayed diagnosis and under-detection of the disease in the general population, leading to a significantly underestimated estimate of its prevalence [29, 30].

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Schindl, A., M. Schindl, Heidemarie Pernerstorfer-Schön, and Liesbeth Schindl. "Low intensity laser therapy in wound healing — a review with special respect to diabetic angiopathies." European Surgery 33, no. 3 (May 2001): 132–37. http://dx.doi.org/10.1007/bf02949466.

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Schindl, A., M. Schindl1, Heidemarie Pernerstorfer-Schon2, and Liesbeth Schindl1. "Low Intensity Laser Therapy in Wound Healing - a Review with Special Respect to Diabetic Angiopathies." European Surgery-Acta Chirurgica Austriaca 33, no. 3 (July 2001): 132–37. http://dx.doi.org/10.1046/j.1563-2563.2001.01067.x.

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K, Kavana, and Sharath Kumar B.C. "Cutaneous Manifestations of Diabetes Mellitus in a Tertiary Care Hospital in Bengaluru – A Cross Sectional Study." Journal of Evidence Based Medicine and Healthcare 8, no. 19 (May 10, 2021): 1352–56. http://dx.doi.org/10.18410/jebmh/2021/258.

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BACKGROUND “Skin is a mirror of internal diseases”. Diabetes mellitus (DM) is a metabolic disorder that needs considerations of many different specialities but the importance of dermatologist’s knowledge has not drawn much attention. As a result, we intend to study various cutaneous manifestation of diabetes mellitus. Prior to diagnosis of diabetes mellitus, patient may present with cutaneous manifestation. Thus, it can help in early diagnosis, management and prevention of complication and help in improvement of quality of life. METHODS This is a descriptive cross-sectional study. A total of 500 diabetic patients with cutaneous manifestations, who attended skin outpatient department (OPD) at Kempegowda Institute of Medical Sciences Hospital and Research Centre, Bengaluru, Karnataka, India, were evaluated. Detailed history was taken along with physical and mucocutaneous examination. Cutaneous manifestations, general description of diabetes mellitus like duration, type, and drug history as well as the demographic data were collected and analysed using descriptive statistics. RESULTS Among a total of 500 diabetes mellitus subjects, the most common cutaneous manifestations were infections (35 %) followed by pruritus (11 %). Among infections, tinea infections (48.29 %) were the most common followed by intertrigo (21 %). CONCLUSIONS The ignorance of skin manifestations in diabetes or improper treatment may worsen the condition. Early detection and treatment of common skin manifestations in diabetes will prevent further complications especially in cases of extensive tinea corporis, pruritus, psoriasis, lichen planus, macro and micro angiopathies, trophic ulcers etc. KEYWORDS Cutaneous manifestations, Diabetes mellitus

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Kosobyan, Evgenia Pavlovna, Ivona Renata Yarek-Martynova, Alexander Sergeevich Parfenov, Lyubov' Leonidovna Bolotskaya, and Marina Vladimirovna Shestakova. "Assessment of endothelial function and arterial rigidity in patients with type 1 diabetes at different stages of diabetic nephropathy." Diabetes mellitus 14, no. 3 (September 15, 2011): 55–59. http://dx.doi.org/10.14341/2072-0351-6225.

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Aim. Assessment of vascular stiffness and endothelial function in patients with type 1 diabetes at different stages of diabetic nephropathy and without it. Materials and methods. We examined 93 patients with DM1 aged 18 to 40 years, and disease duration of more than 5 years. The criterion for forming groups is the stage of diabetic nephropathy. Control group consisted of 23 healthy people. The study included an evaluation of the contour of pulse wave analysis, and conducting tests with reactive hyperemia on the unit Angioskan (LTD Angioskan, Russia). Prior to the study of each patients written informed consent. Results. In conducting the analysis of the pulse wave contour index of aortic stiffness was significantly higher in all groups of patients with diabetic nephropathy (DN) compared with healthy subjects. However, when comparing patients with T1D without DN and the control group, significant differences of stiffness index (SI) was not been determined. It should be noted that the increase in value of SI is almost independent of the presence of hypertension in the patient groups. In the analysis of reflection index (RI) values of statistically significant relationships were found. In analyzing the test data with reactive hyperemia we showed a reduction in growth of the signal amplitude in a significant number of patients, which is a sign of endothelial dysfunction, and occurs even in patients without clinical and laboratory signs of kidney damage. However, along with a decrease of this index, a large number of patients have paradoxically high its value, which may indicate a high level of basal nitric oxide. Conclusion. Increase in the stiffness of the aorta, the progression of DN may be an early marker of macrovascular lesions even in patients without hypertension. Reduced growth of the amplitude of the signal after occlusion in patients with no signs of kidney disease, indicates the presence of endothelial dysfunction even in the preclinical stage of diabetic nephropathy. Paradoxically high increase of the amplitude of the signal can indicate the presence of abnormally high basal level of nitric oxide, which is a marker of inflammation, high-risk factor of progression of angiopathies and fibrosis.

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Kosobian, E. P., I. Ia Iarek-Martynova, A. S. Parfenov, and M. V. Shestakova. "The vasomotor function of endothelium and elasticity of the arterial wall in the patients with type 1 diabetes mellitus at different stages of diabetic retinopathy." Problems of Endocrinology 58, no. 4 (August 15, 2012): 22–26. http://dx.doi.org/10.14341/probl201258422-26.

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The objective of the present work was to estimate the degree of rigidity of the vascular wall and endothelial function in the patients with type 1 diabetes mellitus at different stages of diabetic retinopathy and in its absence. The study included 118 patients at the age from 18 to 40 years presenting with type 1 diabetes mellitus more than 5 years in duration. The patients were divided into several groups based on the stage of diabetic retinopathy (DR). The control group was comprised of 23 healthy subjects. The contour pulsed wave analysis and the reactive hyperemia test were performed with the use of an Angioscan device. All the patients gave the informed consent to participate in the study. The aortic stiffness index (SI) in all groups of the patents with DM1 and DR was higher than in the healthy subjects. However, the SI values remained normal in the DM1 patients without DR. An increase of SI values was unrelated to the presence of arterial hypertension. The analysis of RI values revealed no statistically significant differences between the groups. The reactive hyperemia test has demonstrated a decrease in the increment of the post-occlusive signal amplitude in a large number of patients suggesting endothelial dysfunction. This decrease was apparent even in the patients exhibiting no signs of retinal damage. However, despite the overall decrease of this parameter, many patients showed its paradoxically high values that probably reflected the elevated baseline level of nitric oxide. The increase of aortic stiffness index with the progression of diabetic retinopathy may be used as an early marker of macrovascular complications even in the patients without arterial hypertension. The lowering of the increment of the post-occlusive signal amplitude in the patients having no signs of retinal damage is indicative of endothelial dysfunction as early as the preclinical stage of DR development. The paradoxically high increment of the signal amplitude is supposed to be associated with the elevation of the baseline level of nitric oxide that in its turn reflects the severity of inflammation and is a factor of high risk of progression of angiopathies.

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Trusov, V. V., K. V. Aksenov, and I. B. Cheremiskina. "Microcirculatory disorders in patients with type 1 diabetes mellitus with nephropathy and correction." Problems of Endocrinology 50, no. 5 (October 15, 2004): 24–27. http://dx.doi.org/10.14341/probl11517.

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Despite the fact that the pathophysiology of vascular events is under intensive studies, their mechanisms have not been conclusively established so far. Greater and greater emphasis is recently laid on blood coagulative changes that are responsible for the development of angiopathies in the presence of diabetes mellitus (DM), the specific features of microcirculatory disorders and ways of their correction being insufficiently studied. The purpose of this study was to detect microcirculatory hemodynamic disorders in patients with type 1 DM in relation to the stage of diabetic neuropathy (DN) and to correct it with moxonidine, by evaluating its antihypertensive and nephroprotective effects. The study included 108 patients with type 1 DM whose age was 20 to 33 years. They were divided into 3 groups by the stages of DN according the to 2000 classification recommended by the Ministry of Health of the Russian Federation. The patients of these groups were examined in accordance with a special programme. The microcirculation was evaluated by using an original unit for computer-aided digital processing of microcirculatory images (S.B. Zhuplatov, 1994) based on the Knizelly bulbar biomicroscopic procedure (1968). The study has revealed that the severity of microcirculatory disorders depends on the stage of DN. Having a pronounced antihypertensive effect, moxonidine improves microcirculation, exerts a nephrotoxic effect, diminishes insulin resistance and may be used to correct blood pressure in patients with type 1 DM concurrent with DN.

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Савич, А. О., Л. С. Криськів, and Л. М. Мосула. "Determination of the total content of flavonoids in herbal mixtures with anti-diabetic activity." Farmatsevtychnyi zhurnal, no. 5 (October 22, 2021): 77–84. http://dx.doi.org/10.32352/0367-3057.5.21.08.

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Diabetes mellitus is an important social and medical problem, as it causes the development of dangerous complications that lead to disability and mortality. This disease is characterized by a multi-vector pathogenesis that requires a comprehensive approach to treatment. Due to the use of mixtures of medicinal plants in the treatment of diabetes, it is possible to cover all aspects of the development of this disease and its complications, because the combination of different medicinal plants contain more biologically active substances that affect all parts of the pathogenetic mechanism of diabetes mellitus and its complications. Plant biocompounds have a wide range of pharmacological action and various mechanisms of influence on the development of diabetes and diabetic angiopathies (inactivation of the antioxidant defense system, activation of lipid peroxidation and the development of oxidative stress). In addition, the niche of the pharmaceutical market of Ukraine with phytomixtures is almost empty. The aim of the work was to study the total flavonoid content in some herbal mixtures, which have established hypoglycemic, hypolipidemic and antioxidant activity in previous studies in vivo The study of the total flavonoid content in herbal samples was carried out by UV-spectrophotometry with the recording of the absorption spectrum of complexation product of flavonoids with aluminum chloride (λmax 415 nm) in terms of rutin. According to the results of UV-spectrophotometric determination, it was found that the total flavonoid content in the herbal mixture No 3 was 1.47 ± 0.04%, in the herbal mixture No 4 – 1.78 ± 0.04%, in the herbal mixture No 7 – 1.29 ± 0.02%, in the herbal mixture No 13 – 1.16 ± 0.02% and in the herbal mixture No 19 – 3.62 ± 0.06% in terms of rutin. It was found that the best flavonoid content (3.62 ± 0.06%) was found in the plant mixture № 19, which contains nettle leaves, dandelion roots, blueberry leaves, rose hips and peppermint herb. Phytochemical studies may indicate a correlation between the content of flavonoids and pharmacological properties of the studied mixtures, because the functional hydroxyl groups of the latter cause strong antioxidant activity by neutralizing free radicals, chelation of heavy metal ions, increasing the activity of antioxidant protection products, which has been confirmed in previous in vivo and in vitro studies.

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Bespalova, V. A., and M. Kundurovich. "Workshop on «Essential» Phospholipids in the Treatment of Diabetes Mellitus and Dyslipidemias." Problems of Endocrinology 40, no. 3 (December 15, 1994): 63. http://dx.doi.org/10.14341/probl12055.

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A scientific and practical symposium Essential phospholipids in the treatment of diabetes mellitus and dyslipidemia organized by RON-PULENK RORER (Cologne, Germany) was held at the State Central Scientific Medical Library of the Ministry of Health of Russia. The basic concept of the development of dyslipidemia (DLP) and the working classification of this metabolic state were presented in a report by Yu. A. Knyazev (Moscow). In the message K. Gundermann et al. (Cologne, Germany) the mechanism of action of essential phospholipids (EPL) at the molecular level, the level of insulin receptor and postreceptor interactions in cytomembranes, as well as in lipolytic and cholinesterizing enzyme systems was described. The feasibility of using EPL preparations for the prevention of diabetic angiopathies (AP) by transplanting pancreatic incretory cell cultures, with conservative and surgical treatment of AP with the aim of stabilizing or even reversing the development of atherosclerotic vascular lesions, was substantiated in a report by A. A. Chirkin et al. (Vitebsk, Belarus). The results of the study of intravascular microcirculation in patients with diabetes with clinical signs of AP made it possible to evaluate lipostabil (a drug containing EPL and prescribed together with hypoglycemic agents) as an effective tool in the plasma-cell type of microcirculatory disorders in patients with diabetes aged 19 to 68 years (I. M Kakhnovsky et al., Moscow). Under the influence of lipostabil forte, an increase in insulin sensitivity is possible (L. L. Vakhrusheva et al., Moscow), which underlies a decrease in the need for exogenous insulin and a tendency to normalize indicators of carbohydrate and fat metabolism, the level of counterinsulin hormones. 6 months after the start of lipostabil forte administration, an inhibition of AP progression was noted against the background of an adequate dose of insulin.

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Kurylo, Kh I., A. S. Volska, I. M. Klishch, and B. V. Zablotskyi. "СУЧАСНІ ПІДХОДИ ДО ФАРМАКОЛОГІЧНОЇ КОРЕКЦІЇ МЕТАБОЛІЧНИХ ЗРУШЕНЬ ПРИ ЦУКРОВОМУ ДІАБЕТІ ТИПУ 2." Scientific Issue Ternopil Volodymyr Hnatiuk National Pedagogical University. Series: Biology 77, no. 3 (September 24, 2019): 71–80. http://dx.doi.org/10.25128/2078-2357.19.3.10.

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Diabetes mellitus is caused by one of the largest medical and social problems in Ukraine, because it causes a high risk of invasive disease. According to the WHO data, the number of patients is rising and people of varying age groups become ill, which causes an increase in the incidence of 3 to 4 pauses and the overall life expectancy of 20-30%. Pathogenesis of diabetes mellitus and enclosure, require the extraction of drugs for prophylaxis and treatment with late pharmacological effects. One of these is a herbal remedy. Analysis and systematization of the literature on metabolitotropic effects and substantiation of the use of new goat's-rue, blueberry and taurine phytocompositions for the correction of metabolic changes in diabetes type 2 were carried out. The methods of information search, analysis of literature on the medicinal plants with hypoglycemic action were used. The literary resources on pharmacological correction of metabolic changes in diabetes type 2 deal with natural herbs and amino acids that possess hypoglycemic action and can be used with therapeutic and prophylactic measure in patients with type 2 diabetes. In type 2 diabetes mellitus significant anticytolytic, detoxifying and antioxidant properties of phytocompositions were confirmed. It is known that in hyperglycemia and insulin resistance that occur at type 2 diabetes mellitus end products of glycosylation and glucose autooxidation are formed, which is accompanied by the activation of lipid peroxidation and the formation of a large number of free radicals. It is known that one of the basic mechanisms for the development of insulin resistance, diabetes mellitus and specific diabetic angiopathies is oxidative stress. One of the major pathogenetic factors in the development and course of type 2 diabetes mellitus is metabolic syndrome. It has been established that correction using both investigated phytocompositions and reference phytopreparation with different efficiency prevented the development of metabolic changes in metabolic syndrome. Biologically active components of medicinal plants, may show hypoglycemic effect which will influence the activity of the enzymes, glucose transcription and the function of the peptide to the incyline, the processes which play an important role in the pathogenesis of diabetes.

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Balashova, T. S., Ye N. Golega, I. A. Rudko, M. I. Balabolkin, and A. A. Kubatiev. "Biosynthetic insulin effect on red cell membrane lipid peroxidation in patients with insulin-dependent diabetes." Problems of Endocrinology 40, no. 3 (December 15, 1994): 12–15. http://dx.doi.org/10.14341/probl12003.

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The aim of our research was elucidation of a relationship between red cell membrane lipid peroxidation (LPO) and antioxidant' defense enzymes, on the one hand and the age disease duration and presence of vascular complications in patients with type I diabetes mellitus on the other. The possibility of correcting red cell peroxide status with human insulin preparations was investigated. Red cell membrane LPO was found increased more than twofold and antioxidant defense enzymes activities virtually unchanged vs. controls in 16 patients with diabetes aged 20 to 43. These characteristics of red cell peroxidation status do not depend on patients age disease standing or presence of vascular complications. A twelve-week therapy with biosynthetic insulin resulted in complete normalization of LPO processes in patients with angiopathies aged under 35 and with disease standing of less than 10 years. In diabetics with angiopathies aged over 35 and disease standing of more than 10 years red cell MDA level reduced under the effect of therapy with human insulin preparations but was still increased vs. that in healthy donors by 1.5 times. Red cell GP and SOD activities reduced in the course of insulin therapy in all the examined groups of diabetics. Catalase activity increased by approximately 50% in patients with angiopathies those aged over 35 and a disease standing of more than 10 years under the effect of insulin. In the rest groups of patients catalase activity did not differ from its initial level. Our results permit us recommending besides human insulin preparations antioxidant therapy for patients with vascular complications those aged over 35 and a disease standing of more than 10 years.

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Kalinovic, R., B. Tinca, O. Neda-Stepan, M. Dinescu, C. Giurgi-Oncu, I. Enatescu, and V. R. Enatescu. "The particularities of microangiopathic and macroangiopathic complications in type 2 diabetes mellitus patients correlated with the presence or absence of type D personality." European Psychiatry 64, S1 (April 2021): S246—S247. http://dx.doi.org/10.1192/j.eurpsy.2021.661.

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IntroductionAccording to our national data based on PREDATORR study, the point prevalence of diabetes mellitus in Romania was 11.6 % in adults between 20 and 79 years old. Unequivocally, type 2 diabetes mellitus is highly correlated with psychological and personality factors.ObjectivesThe objective of our research was to evaluate the frequency of type D personality in patients suffering from type 2 diabetes and its influence on angiopathic complications.MethodsA cross-sectional study was conducted in 173 patients with type 2 diabetes who were self-assessed by using Beck Depression Inventory I, STAI-Y scale and DS 14 scale for detection of type D personality.ResultsBoth depression (p = 0.012) and state and trait anxiety (p = 0.019 and 0.023 respectively) scores were significantly higher in diabetic patients with type D personality compared with non-type D diabetic patients. Lower limb complications were more frequent in non-type D personality diabetics (p = 0.018) while diabetic retinopathy and diabetic polyneuropathy (p = 0.004 and p = 0.010 respectively).ConclusionsThe presence of type D personality has a supplementary negative impact on type 2 diabetic patients’ affectivity and emotions. On the one hand, the more frequent microangiopathic complications in type D personality diabetic patients confirm that diabetes, at least in part, is an endovascular disease. On the other hand, some factors such as pro-inflammatory biomarkers may be more expressed in type 2 diabetic patients with concomitantly type D personality than those without this type of personality, leading to premature microangiopathic complications.

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Gröber, Uwe. "Diabetische Angiopathien." Zeitschrift für Orthomolekulare Medizin 19, no. 03 (October 2021): 29–32. http://dx.doi.org/10.1055/a-1616-9019.

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ZusammenfassungIn Europa ist Deutschland das Land mit der höchsten Prävalenz für Diabetes mellitus mit stark zunehmender Tendenz. Der überwiegende Teil der Patienten ist am Typ-2-Diabetes erkrankt. Die diabetisch bedingten Mikro- und Makroangiopathien können zu einer Reihe Spätfolgen wie Gefäß-, Nerven- und Organschäden führen. Sie beruhen auf Induktion prooxidativer und entzündlicher Prozesse, die insb. auf eine mitochondriale Mehrproduktion von Superoxidradikalen (-O2 •) und anderen reaktiven Sauerstoffspezies (ROS) zurückzuführen sind. Die Kompensation von Mikronährstoffmängeln und eine frühzeitige Supplementierung mit Mikronährstoffen ist eine vielversprechende Therapieoption.

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Balabolkin, M. I., A. A. Kubatiyev, I. A. Rudko, Ye N. Golega, and G. N. Sushkevich. "Platelet functional activity in patients with insulin-dependent diabetes mellitus." Problems of Endocrinology 41, no. 1 (February 15, 1995): 6–9. http://dx.doi.org/10.14341/probl11323.

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Platelet aggregability and the reaction of isolation of thrombocytic granules were studied in 17 patients with type 1 diabetes mellitus with and without vascular involvement over the course of therapy with human insulin preparations (Lilly, France). Platelet aggregation in response to low concentrations of ADP and adrenalin was found increased; in patients with angiopathies no changes were induced by 5 mcM of ADP and collagen. In the patients without vascular involvement platelet aggregation was the same as in donors. The content of ATP released in the course of ADP or collagen-included aggregation reduced in the diabetics in comparison with donors irrespective of the presence of vascular complications, the lower level of ATP observed, however, in the patients without angiopathies. Our data indicate platelet hyperactivation and devastation of platelet granules in uncomplicated diabetes mellitus. Therapy with Lilly insulins was conducive to recovery of the functional activity of platelets which normalized 6 weeks after therapy was started, no matter what types of insulin were administered. The detected changes seem to be largely due to the effects of insulins proper but not so much to the compensation of glucose level, because they were unidirectional in the groups of patients with subcompensated and compensated diabetes.

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Lawall, Amann, Rottmann, and Angelkort. "Stellenwert von mikrozirkulatorischen Untersuchungsmethoden bei Patienten mit diabetischem Fuß-Syndrom." Vasa 29, no. 3 (August 1, 2000): 191–97. http://dx.doi.org/10.1024/0301-1526.29.3.191.

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Background: Diabetic foot syndrome (DFS) is a frequent complication of long-standing diabetes mellitus, occurring in 10 to 30 percent of all diabetics with a vital risk for the affected limb and high mortality rates. Macroangiopathy, diabetic polyneuropathy and infections are trigger factors for DFS. Recent results imply a pathogenic role of functional and structural microcirculatory changes. The exact role of microangiopathy and the value of microcirculatory diagnostic methods in DFS have not yet been defined. Patients and methods: 78 patients with DFS (28 type I, 50 type II diabetics, mean age 63 years) were evaluated with video capillary microscopy, transcutaneous partial oxygen tension (tcpO2) measurement and laser Doppler fluxmetry (LDF) at the forefoot of the affected leg at admission and after revascularisation. Mean hospital stay was 28 ± 11.7 days. Patients were stratified according to the etiology of DFS in patients with neuropathic lesions, macroangiopathic ulcers and mixed neuropathic-angiopathic lesions. Results: All groups had impaired microcirculation, and significant differences between groups were found in respect to capillary density. Reactive hyperemia, LDF pattern and tcpO2 did not differ significantly. Microcirculatory examinations did not yield additional information to clinical and Doppler sonographic results. Conclusion: In clinical practice, the role of microcirculation evaluation techniques for diabetic foot syndrome is limited.

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Monge, Luca. "Complicated plantar ulcer in diabetic patient with multiple comorbidities." AboutOpen 4, no. 1 (July 31, 2018): 86–88. http://dx.doi.org/10.19156/abtpn.2018.0049.

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Diabetic foot syndrome is characterized by an intrinsic patient fragility and involves complex medical and surgical therapeutic approach. Lesions, often chronic, have a high risk of recurrence and amputation. The patient with diabetic foot is more frequently affected by comorbidities, not only for micro-angiopathic complications of diabetes mellitus but also for the frequent presence of cardiovascular disease. We report the case of a 63-year-old diabetic patient with multiple comorbidities. Treatment with linagliptin allowed to simplify the therapy for glycemic control, switching from a injective therapy four times daily to a therapy with only basal insulin and linagliptin. This therapy has proven to be safe and suitable to maintain good glycemic control even in a fragile patient with diabetic foot and middle-severe renal insufficiency of diabetic origin (Diabetology).

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Lohmann, T. "Führung des Diabetes mellitus bei Angiopathien." Zeitschrift für Kardiologie 94, S4 (December 2005): iv28—iv30. http://dx.doi.org/10.1007/s00392-005-1408-6.

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Rittig, Kilian. "Die diabetische Angiopathie." Diabetes aktuell 18, no. 05 (August 2020): 200–207. http://dx.doi.org/10.1055/a-1215-5503.

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ZUSAMMENFASSUNGDie massiv steigenden Zahlen der Diabeteserkrankung in Deutschland und weltweit sowie die damit vergesellschaftete Steigerung der mikro- und makrovaskulären Komplikationen dieser Patienten stellt ein massives gesundheitspolitisches und volkswirtschaftliches Problem dar. Noch vor wenigen Jahren standen uns zur medikamentösen Therapie dieser Patienten im Wesentlichen nur Substanzen zur Verfügung, für die kein oder nur ein geringer Nutzen im Hinblick auf die Reduzierung des kardiovaskulären Risikos belegt war. Die Höhe des HbA1c-Werts war die einzige Richtschnur für die Einschätzung der Güte der Einstellung des Glukosestoffwechsels. Seit einigen Jahren stehen jedoch zunehmend Substanzen zur Verfügung, für die ein positiver Effekt auf das kardiovaskuläre Überleben der Diabetespatienten eindrücklich belegt wurde, und die seitdem Einzug in den klinischen Alltag gehalten haben. Vor allem die Einführung der GLP-1-Rezeptoragonisten und der SGLT-2-Inhibitoren haben uns hier ganz neue Therapiemöglichkeiten eröffnet. Auch im Hinblick auf die Diagnostik einer Atherosklerose, insbesondere der pAVK, gilt es bei Menschen mit Diabetes einige Besonderheiten zu beachten, auf die in dieser Übersicht eingegangen wird. Die stetig steigende Zahl der Diabetespatienten mit und ohne Gefäßkomplikationen stellt das Gesundheitssystem und uns Behandler vor gravierende Herausforderungen, die in den nächsten Jahren noch wachsen werden. Diesen werden wir nur gemeinsam und interdisziplinär begegnen können.

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Васильева, L. Vasileva, Никитин, A. Nikitin, Васильева, E. Vasileva, Лубягина, and E. Lubyagina. "Early diagnosis and prevention of cardiovascular risk in the patients with type II diabetes." Journal of New Medical Technologies. eJournal 8, no. 1 (November 5, 2014): 1–5. http://dx.doi.org/10.12737/4106.

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In the paper the relevance of research associated with a high incidence in the world diabetes type 2 diabetes, with often development in patients with early and late, micro - and macro-vascular complications leading to disability and mortality is justified. The results of study on the complex clinical and anamnestic, biochemical, metabolic, functional risk factors for cardiovascular diseases are presented. By means of multivariate mathematical modeling the most informative predictors of complications and their combinations, associated with increased susceptibility to the development of macro-angiopathies in the patients with diabetes mellitus type 2, were defined. The importance of lipid disorders, metabolic profile and homocysteine in the development of cardiovascular complications and their progression based on the study of the correlation between homocysteine with lipoproteins in various forms macro-angiopathies of patients with diabetes type 2, has been demonstrated. Timely correction of identified violations promotes positive dynamics of metabolic processes and on this background, to reduce the frequency of cardiovascular complications. The obtained data contribute to a better understanding of the mechanisms of formation, disposition, development, clinical course and outcome of diseases, identification of the population of persons with risk factors for the purpose of prevention activities.

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Odawara, Masato. "2) Diabetes Mellitus and Micro-and Macro-angiopathies." Nihon Naika Gakkai Zasshi 109, Suppl (February 26, 2020): 120b—121a. http://dx.doi.org/10.2169/naika.109.120b.

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Odawara, Masato. "2) Diabetes Mellitus and Micro-and Macro-angiopathies." Nihon Naika Gakkai Zasshi 109, no. 9 (September 10, 2020): 1809–14. http://dx.doi.org/10.2169/naika.109.1809.

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Wakasugi, Hideyuki, Yasuhiro Hara, Muneaki Abe, and Yasaburo Katsuda. "Angiopathies in Pancreatic Diabetes Resulting from Chronic Pancreatitis." International Journal of Gastrointestinal Cancer 23, no. 2 (1998): 175–80. http://dx.doi.org/10.1385/ijgc:23:2:175.

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Enatescu, V. R., I. Papava, R. S. Romosan, A. Grozavu, V. Enatescu, I. Enatescu, and L. Diaconu. "The impact of type D personality on the quality of life and on microangiopathic and macroangiopathic complications in outpatients with type 2 diabetes mellitus." European Psychiatry 41, S1 (April 2017): S491—S492. http://dx.doi.org/10.1016/j.eurpsy.2017.01.600.

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IntroductionIn 2015, the worldwide point prevalence for diabetes mellitus was 8.8%. Type D personality was found as being more prevalent in type 2 diabetes than in the general population.ObjectivesWe aimed to reveal the frequency of type D personality and to analyze the impact of type D personality on both quality of life and angiopathic complications, in patients with type 2 diabetes from our region.MethodsA cross-sectional research was performed on 79 outpatients that were monitored for diabetes mellitus at Timisoara diabetes, nutrition and metabolic diseases clinic. Type D personality was assessed with the DS-14 scale. Quality of life was quantified by using the Q-LES-Q-SF scale (Quality of Life Enjoyment and Satisfaction Questionnaire-Short Form). The angiopathic complications were abstracted from medical records.ResultsType D personality was present in 38 subjects with diabetes mellitus (48.10%). Compared to those without type D personality, patients with type D personality and diabetes had significant lower mean scores for the following domains of the Q-LES-Q-SF scale: social relationships (P < 0.001), daily life function (P = 0.027), sexual activity (P = 0.005), to get around physically (P < 0.001), work or hobbies (P = 0.008) and raw score (P = 0.003). Type D personality did not make any difference regarding micro and macroangiopathic complications of type 2 diabetes patients.ConclusionsType D personality, a highly frequent entity, did not make the difference with respect to diabetic complications; however, it may interfere significantly with several facets of the quality of life of these patients. These results should be taken into account for an interdisciplinary approach to these patients.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Chittar, Hemangini S., K. D. Nihalani, Prema K. Varthakavi, and Shobha A. Udipi. "Lipid peroxide levels in diabetics with micro- and macro-angiopathies." Journal of Nutritional Biochemistry 5, no. 9 (September 1994): 442–45. http://dx.doi.org/10.1016/0955-2863(94)90077-9.

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Journal articles on the topic 'Diabetic angiopathies'

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