Relevant bibliographies by topics / DHA

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  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
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Academic literature on the topic 'DHA'

Author: Grafiati
Published: 4 June 2021
Last updated: 7 July 2024

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Journal articles on the topic "DHA"

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Kim, Hee-Yong, Hyun-Seuk Moon, Dehua Cao, Jeongrim Lee, Karl Kevala, Sang Beom Jun, David M. Lovinger, Mohammed Akbar, and Bill X. Huang. "N-Docosahexaenoylethanolamide promotes development of hippocampal neurons." Biochemical Journal 435, no. 2 (March 29, 2011): 327–36. http://dx.doi.org/10.1042/bj20102118.

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DHA (docosahexaenoic acid, C22:6,n−3) has been shown to promote neurite growth and synaptogenesis in embryonic hippocampal neurons, supporting the importance of DHA known for hippocampus-related learning and memory function. In the present study, we demonstrate that DHA metabolism to DEA (N-docosahexaenoylethanolamide) is a significant mechanism for hippocampal neuronal development, contributing to synaptic function. We found that a fatty acid amide hydrolase inhibitor URB597 potentiates DHA-induced neurite growth, synaptogenesis and synaptic protein expression. Active metabolism of DHA to DEA was observed in embryonic day 18 hippocampal neuronal cultures, which was increased further by URB597. Synthetic DEA promoted hippocampal neurite growth and synaptogenesis at substantially lower concentrations in comparison with DHA. DEA-treated neurons increased the expression of synapsins and glutamate receptor subunits and exhibited enhanced glutamatergic synaptic activity, as was the case for DHA. The DEA level in mouse fetal hippocampi was altered according to the maternal dietary supply of n–3 fatty acids, suggesting that DEA formation is a relevant in vivo process responding to the DHA status. In conclusion, DHA metabolism to DEA is a significant biochemical mechanism for neurite growth, synaptogenesis and synaptic protein expression, leading to enhanced glutamatergic synaptic function. The novel DEA-dependent mechanism offers a new molecular insight into hippocampal neurodevelopment and function.
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Zboya, Eric. "DHA #2." ti< 2, no. 1 (April 7, 2013): 89. http://dx.doi.org/10.26522/ti.v2i1.776.

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Brenna, J. Thomas. "DHA retroconversion revisited: dietary DHA spares endogenous EPA." American Journal of Clinical Nutrition 110, no. 4 (June 28, 2019): 789–90. http://dx.doi.org/10.1093/ajcn/nqz125.

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Brenna, J. Thomas. "Episodic Dietary DHA for Support of Tissue DHA." Journal of Nutrition 149, no. 4 (March 30, 2019): 547–48. http://dx.doi.org/10.1093/jn/nxy314.

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Murphy, Rachel A., Prasad P. Devarshi, Shauna Ekimura, Keri Marshall, and Susan Hazels Mitmesser. "Long-chain omega-3 fatty acid serum concentrations across life stages in the USA: an analysis of NHANES 2011–2012." BMJ Open 11, no. 5 (May 2021): e043301. http://dx.doi.org/10.1136/bmjopen-2020-043301.

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ObjectiveTo determine reference ranges of circulating long-chain (LC) omega-3 fatty acids: eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA) in a nationally representative population of Americans. To provide context, serum concentrations of LC omega-3 were compared with concentrations associated with consuming the recommended amount of EPA and DHA by the Dietary Guidelines for Americans (DGA) and the Omega-3 Index (EPA+DHA).DesignCross-sectional population-based study.SettingThe National Health and Nutrition Examination Survey 2011–2012 cycle.ParticipantsParticipants with fatty acids measured in serum: 945 children, age 3–19 years, and 1316 adults, age 20 and older.Main measureSerum EPA, DPA, DHA and sum of LC omega-3 fatty acids expressed as per cent of total fatty acids.ResultsAmong children, mean (SE) serum concentrations of EPA, DHA and omega-3s were 0.28% (0.01), 1.07% (0.02) and 1.75% (0.03). Among adults, mean (SE) of EPA, DHA and omega-3s were 0.61% (0.02), 1.38% (0.05) and 2.43% (0.08), all of which were significantly higher than corresponding serum fatty acid concentrations in children (p<0.001). Despite recommendations for higher intake, pregnant and/or breastfeeding women had mean (SE) EPA, DHA and LC omega-3 concentrations of 0.34% (0.07), 1.52% (0.08) and 2.18% (0.15), which were comparable to women of childbearing age; p=0.17, p=0.10 and p=0.73. Over 95% of children and 68% of adults had LC omega-3 concentrations below those associated with the DGA recommendation. Approximately 89% of adults had an Omega-3 Index in the high cardiovascular risk category.ConclusionsContemporary reference ranges for circulating LC omega-3s are critical for setting public health recommendations. Our findings show the need for continued emphasis on regular consumption of LC omega-3s among Americans, particularly considering the importance of LC omega-3s in cardiovascular health, brain health and development throughout life.
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Léger, Claude L. "L’acide docosahexaénoïque (DHA)." Oléagineux, Corps gras, Lipides 14, no. 1 (January 2007): 10. http://dx.doi.org/10.1051/ocl.2007.0010.

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Gientka, Iwona. "Mikrobiologiczne źródła DHA." PRZEMYSŁ SPOŻYWCZY 1, no. 11 (November 5, 2016): 27–29. http://dx.doi.org/10.15199/65.2016.11.6.

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Sugasini, Dhavamani, Poorna C. R. Yalagala, and Papasani V. Subbaiah. "Efficient Enrichment of Retinal DHA with Dietary Lysophosphatidylcholine-DHA: Potential Application for Retinopathies." Nutrients 12, no. 10 (October 12, 2020): 3114. http://dx.doi.org/10.3390/nu12103114.

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Although decreased retinal docosahexaenoic acid (DHA) is a known risk factor for retinopathy, currently available omega-3 fatty acid supplements, which are absorbed as triacylglycerol (TAG), do not significantly enrich retinal DHA. We tested the hypothesis that lysophospahtidylcholine (LPC)-DHA which is absorbed as phospholipid, would efficiently increase retinal DHA because of the presence of LPC-specific transporter at the blood–retina barrier. In normal rats, LPC-DHA and di-DHA phosphatidylcholine (PC), which generates LPC-DHA during digestion, increased retinal DHA by 101% and 45%, respectively, but TAG-DHA had no significant effect at the same dose (40 mg/kg, 30 days). In normal mice, both sn-1 DHA LPC and sn-2 DHA LPC increased retinal DHA by 80%, but free DHA had no effect. Lipase-treated krill oil (which contains LPC-DHA and LPC-EPA (eicosapentaenoic acid), but not normal krill oil (which has little LPC), increased both retinal DHA (+76%) and EPA (100-fold). Fish oil, however, had no effect, whether lipase-treated or not. These studies show that retinal DHA can be efficiently increased by dietary LPC-DHA, but not by TAG-DHA or free DHA. Since DHA is known to be protective against retinopathy and other eye diseases, this study provides a novel nutraceutical approach for the prevention/treatment of these diseases.
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Yue, Hao, Yingying Tian, Zifang Zhao, Yuying Bo, Yao Guo, and Jingfeng Wang. "Comparative Study of Docosahexaenoic Acid with Different Molecular Forms for Promoting Apoptosis of the 95D Non-Small-Cell Lung Cancer Cells in a PPARγ-Dependent Manner." Marine Drugs 20, no. 10 (September 23, 2022): 599. http://dx.doi.org/10.3390/md20100599.

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Cancer is a leading cause of death in worldwide. Growing evidence has shown that docosahexaenoic acid (DHA) has ameliorative effects on cancer. However, the effects of DHA-enriched phosphatidylcholine (DHA-PC) and efficacy differences between DHA-PC, DHA-triglyceride (DHA-TG), and DHA- ethyl esters (DHA-EE) on cancer cells had not been studied. In this study, 95D lung cancer cells in vitro were used to determine the effects and underlying mechanisms of DHA with different molecular forms. The results showed that DHA-PC and DHA-TG treatment significantly inhibited the growth of 95D cells by 53.7% and 33.8%, whereas DHA-EE had no significantly effect. Morphological analysis showed that DHA-PC and DHA-TG prompted promoted cell contraction, increased concentration of cell heterochromatin, vacuolization of cytoplasm, and edema of endoplasmic reticulum and mitochondria. TUNEL and AO/EB staining indicated that both DHA-PC and DHA-TG promoted cell apoptosis, in which DHA-PC performed better than DHA-TG. Mechanistically, DHA-PC and DHA-TG treatment up-regulated the PPARγ and RXRα signal, inhibited the expression of NF-κB and Bcl-2, and enhanced the expression of Bax and caspase-3, thereby promoting cell apoptosis. In conclusion, DHA-PC exerted superior effects to DHA-TG and DHA-EE in promoting apoptosis in 95D non-small-cell lung cancer cells. These data provide new evidence for the application of DHA in treatment of cancer.
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Mohamad Ali, Dalal, Kevin Hogeveen, Rose-Marie Orhant, Tiphaine Le Gal de Kerangal, Françoise Ergan, Lionel Ulmann, and Gaëlle Pencreac’h. "Lysophosphatidylcholine-DHA Specifically Induces Cytotoxic Effects of the MDA-MB-231 Human Breast Cancer Cell Line In Vitro Comparative Effects with Other Lipids Containing DHA." Nutrients 15, no. 9 (April 29, 2023): 2137. http://dx.doi.org/10.3390/nu15092137.

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Docosahexaenoic acid (DHA, C22:6 ω-3) is a dietary polyunsaturated fatty acid that has an important role in human health. Epidemiological studies linked a high intake of DHA to a reduced risk of certain cancers. Recently, attention focused on how the lipid carrier in which DHA is delivered, i.e., esterified on acylglycerols, phospholipids, or free, affects its biological effects. However, studies comparing the effects of these different forms for DHA supply to cancer cells in vitro are limited. In this study, the effect of free DHA and five lipids carrying one to three DHA chains (LPC-DHA, PC-DHA, MAG-DHA, DAG-DHA and TAG-DHA) on the viability of the MDA-MB-231 breast cancer cell line was compared. Our results revealed a strong structure–function relationship of DHA-carrying lipids on the viability of MDA-MB-231 cells. Glycerophosphocholine-based lipids are the most effective DHA carriers in reducing the viability of MDA-MB-231 cells, with LPC-DHA being more effective (IC50 = 23.7 µM) than PC-DHA (IC50 = 67 µM). The other tested lipids are less toxic (MAG-DHA, free DHA) or even not toxic (DAG-DHA, TAG-DHA) under our conditions. Investigating the mechanism of cell death induced by LPC-DHA revealed increased oxidative stress and membrane cell damage.
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Dissertations / Theses on the topic "DHA"

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Montgomery, Colette. "Maternal docosahexaenoic acid (DHA) supplementation and fetal DHA accretion." Thesis, University of Glasgow, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366298.

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ALTOMARE, FRANCESCO POMPEO. "DHA e sviluppo neurologico." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2010. http://hdl.handle.net/2108/1257.

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Wang, Jun. "Encapsulation of DHA oil as Pickering emulsion : effect on DHA bioaccessibility and metabolism." Thesis, Rennes, Agrocampus Ouest, 2022. https://tel.archives-ouvertes.fr/tel-03711326.

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L'encapsulation peut affecter la digestion et la bioaccessibilité des composés encapsulés, ce qui peut ensuite affecter leur métabolisme. Le but de ce projet était d'étudier les effets de l'encapsulation sur la bioaccessibilité et le métabolisme du DHA, en étudiant une huile de DHA non-encapsulée ou encapsulée, apportée sous forme d'omelette comme matrice alimentaire.L'huile de DHA, composée de triacylglycérols riches en DHA, a été préparée sous forme d'émulsion de Pickering, stabilisée par des isolats de protéines de lactosérum dénaturés par la chaleur. De l'huile pure ou sous forme d’émulsion a ensuite été ajoutée à l’œuf liquide pour obtenir de l’omelette. Les effets de l'encapsulation sur la digestion ont été étudiés à l'aide d'un modèle de digestion statique in vitro pour adulte, puis l’impact sur le métabolisme du DHA a été mesuré sur un modèle rat pris au sevrage.Les résultats ont montré in vitro que l'encapsulation peut augmenter la surface de contact entre l'huile de DHA et les enzymes de digestion, favorisant l'hydrolyse lipasique de l’huile de DHA et améliorant ainsi la bioaccessibilité du DHA. In vivo, l'encapsulation n'a pas impacté le profil global des acides gras, et particulièrement l’accrétion du DHA dans le cerveau. En revanche, le profil des oxylipines, dérivés oxydatifs d’acides gras, a été fortement modifié dans le plasma, le cœur et même le cerveau. Les métabolites dérivés du DHA ont globalement été augmentés tandis que ceux issus des acides gras de la famille n-6 ont été essentiellement atténués.Par conséquent, l'encapsulation de l'huile de DHA pourrait non seulement améliorer la bioaccessibilité du DHA, mais constitue également un facteur clé dans le métabolisme du DHA pour produire des précurseurs de protectines et de maresines, améliorant ainsi le statut de santé global
Encapsulation may affect the digestion and bioaccessibility of the encapsulated bioactive compounds, which in turn affects their metabolism. The purpose of this project was to study the effects of encapsulation on DHA bioaccessibility and metabolism, based on omelet as a food matrix, which contains DHA oil as encapsulated or unencapsulated form.DHA oil composed of DHA-rich triacylglycerols was prepared as a Pickering emulsion, which is stabilized by heat-denatured whey protein isolates. Pure oil or emulsion was then incorporated into eggs and cooked in an omelet. The effects of encapsulation on the digestion and metabolism of DHA were studied by using INFOGEST static in vitro digestion model for adults and in a weanling rat model, respectively.The results showed that encapsulation can increase the contact surface between DHA oil and lipase during the in vitro digestion, thereby promoting the hydrolysis of DHA oil and improving DHA bioaccessibility. In vivo, encapsulation of DHA oil did not modulate the fatty acid profile in tissues, but remarkably modified the oxylipin pattern in plasma, heart and even brain. Specific oxidized metabolites derived from DHA were upgraded while those from n-6 fatty acids were essentially mitigated.Therefore, encapsulation of DHA oil could not only improve the bioaccessibility of DHA, but is also a key factor in the metabolism of DHA to produce protectins and maresins precursors, thereby improving global health status
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Vandal, Milène. "Métabolisme du DHA lors du vieillissement." Mémoire, Université de Sherbrooke, 2008. http://savoirs.usherbrooke.ca/handle/11143/3956.

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L'acide docosahexaénoïque (DHA) est un acide gras polyinsaturé oméga-3 (AGPI [oméga]3) concentré dans le poisson. Il est l'AGPI [oméga]3 présent en plus grande quantité dans le cerveau. Une étude épidémiologique a démontré que la consommation de deux portions de poisson par semaine peut ralentir le rythme du déclin cognitif qui survient avec le vieillissement. Étude SUPPLÉMENT. Objectif : Évaluer le changement plasmatique en AGPI [oméga]3 chez des sujets jeunes et âgés lors d'une supplémentation en acide eicosapentaénoïque (EPA)/DHA. Résultats : Chez les sujets jeunes et âgés, le DHA (73 « 47% et 117 « 68 %) et l'EPA (133 « 67% et 97 « 52%) plasmatiques ont augmenté significativement (p < 0,05) avec la supplémentation. Le pourcentage de DHA était supérieur chez les sujets âgés par rapport aux sujets jeunes avec la supplémentation. Conclusion : Les différences observées entre les sujets jeunes et âgés suggèrent qu'il existe un changement dans le métabolisme du DHA avec le vieillissement. Étude TRACEUR. Objectif : Évaluer l'incorporation du DHA marqué au carbone 13 (indice supérieur 13]C-DHA) dans les lipides totaux plasmatiques et sa [bêta]-oxydation chez des participants jeunes et âgés en bonne santé. Résultats : Initialement, la concentration de DHA dans les lipides totaux plasmatiques était similaire entre les groupes. Le [indice supérieur 13]C-DHA avait tendance (p = 0,055) à s'incorporer davantage chez les participants âgés (0,80 « 0,35 nmol/ml) comparativement aux jeunes (0,35 « 0,12 nmol/ml) quatre heures après la prise du traceur. Conclusions : Ces résultats suggèrent que l'incorporation du DHA dans les lipides plasmatiques et sa [bêta]-oxydation dans les heures suivant son ingestion sont influencés par l'âge. La faible [bêta]-oxydation du DHA sur un mois montre qu'il est davantage conservé pour des rôles structuraux plutôt qu'à des fins énergétiques. Conclusion générale :L'âge est associé à une augmentation de l'incorporation du DHA dans les lipides plasmatiques qui se reflète par la plus grande augmentation du DHA dans le plasma lors d'une supplémentation chez des personnes âgées. À cause de sa plus grande incorporation, davantage de DHA est disponible pour la [bêta]-oxydation, ce qui explique la plus grande quantité de DHA [bêta]-oxydé chez les personnes âgées. Cependant la [bêta]-oxydation du DHA est trop faible pour entrer en contradiction avec les résultats obtenus lors de la supplémentation.--Résumé abrégé par UMI.
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Pauter, Anna Maria. "Metabolic Significance of Systemic DHA Deficiency." Doctoral thesis, Stockholms universitet, Institutionen för molekylär biovetenskap, Wenner-Grens institut, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-134089.

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Fatty acid composition in the body displays a high level of heterogeneity and can rapidly respond to changes in diet regime or to starvation. Homeostasis of the level of certain fatty acids is an important factor for maintenance of structural integrity as well as for proper signaling within the organism. Hence, changes in fatty acid composition have been proposed as an important factor during the pathogenesis of many diseases.Concentration of polyunsaturated fatty acid (PUFA) within the body is modulated by the interplay between dietary intake, endogenous de novo synthesis or mobilization of fatty acids from tissue reservoirs. Endogenous synthesis of PUFA is regulated on different genetic levels as well as the level of substrate availability. Studies have reported a variation in PUFA biosynthesis between different developmental stages, age, gender, during pregnancy, lactation and under conditions of certain disorders. A member of the enzymatic machinery involved in PUFA synthesis is the elongase Elongation of very long-chain fatty acids 2 (ELOVL2) that controls the elongation of PUFA with 22 carbons to produce 24 carbons precursors for the production of the omega-3 PUFA, docosahexaenoic acid (DHA, 22:6n3) and the omega-6 PUFA, docosapentaenoic (DPAn6, 22:5n6). Deletion of Elovl2 in a mouse model (Elovl2KO) leads to systemic DHA deficiency at different physiological and early lifestages, and is related to certain metabolic dysfunctions. Mitochondria of Elovl2KO mice display structural and functional impairment. Compared to wild type littermates, Elovl2KO mice do not gain as much weight after high-fat diet treatment and do not develop hepatic steatosis, despite having a higher level of the positive regulator of denovo lipogenesis, nuclear transcription factor SREBP1c. Resistance to high fat diet induced-obesity in Elovl2KO mice is abolished by DHA supplementation together with high sucrose content in the background diet. In conclusion, deletion of Elovl2 in mice leads to systemic DHA deficiency that has pleiotropic effect on mouse energy metabolism.

At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 2: Manuscript. Paper 3: Manuscript. Paper 4: Manuscript.

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Murigneux, Christine. "Evolution des concentrations plasmatiques de androstenedione, dht, dha, dha-s, t, corticosterone et cortisol chez les lapins males et femelles de la periode prepubertaire a l'age adulte." Clermont-Ferrand 2, 1986. http://www.theses.fr/1986CLF2S847.

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Chez le lapin male ou femelle entre 40 et 150 jours, une methode par chromatographie liquide sur silice greffee permet de separer les 7 steroides. Au cours de la maturation sexuelle, il se produit d'importantes variations de concentrations plasmatiques d'androgenes dans les 2 sexes (episodes secretoires de quelques dizaines de jours). Il n'y a pas de dimorphisme sexuel pour les taux plasmatiques d'androstenedione, de dha et de son sulfate, on peut donc penser que la secretion en est surrenalienne. Chez les femelles, il existe une correlation entre les concentrations d'androgenes et celles de corticosterone ou de cortisol, ce qui suggere que les androgenes sont d'origine surrenalienne. Quelque soit l'origine des androgenes, le probleme de la signification de l'androgenisation plasmatique se pose, notamment entre 70 et 110 jours. Au cours de la maturation sexuelle, il se produit des modifications de synthese dans la surrenale, car chez le lapin adulte male ou femelle, la corticosterone est le principal steroide secrete, tandis que chez l'animal immature, elle est faible et meme inferieure a la corticolemie. Chez le foetus, les observations sont similaires
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Murigneux, Christine. "Evolution des concentrations plasmatiques de Delta 4A, DHT, DHA, DHA-S, T, B et F chez les lapins mâles et femelles de la période prépubertaire à l'âge adulte." Grenoble 2 : ANRT, 1986. http://catalogue.bnf.fr/ark:/12148/cb37599926d.

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Sandri, Jacqueline. "Synthèses totales de l'EPA et du DHA." Aix-Marseille 3, 1994. http://www.theses.fr/1994AIX30032.

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Les acides gras polyinsatures (agp) sont presents dans la structure des membranes biologiques et jouent un role tres important d'un point de vue nutritionnel, car ils sont indispensables au bon fonctionnement de tous les tissus. Ce sont les precurseurs d'une grande variete de produits biologiquement actifs. L'acide arachidonique a ete l'agp le plus etudie, biologiquement et par le nombre de syntheses totales decrites dans la litterature. Actuellement, ce sont les acides gras a haut degre d'insaturation tels que l'acide eicosapentaenoique (epa) et l'acide docosahexaenoique (dha) qui font l'objet d'un grand nombre de travaux. L'acces a ces composes purs, naturels ou modifies, est d'un interet de premiere importance pour les etudes biologiques. Leur synthese est donc une etape indispensable pour mener a bien l'etude de leur metabolisme. Le but de ce travail repose sur la mise au point d'un agent d'homologation a six atomes de carbone permettant d'introduire en une seule etape deux doubles liaisons. Ce nouveau synthon est caracterise par une double liaison de stereochimie cis et a chaque extremite par des groupements fonctionnels suffisamment differencies pour pouvoir reagir, apres transformations, comme reactif ou substrat en reaction de wittig. Nous decrivons son utilisation dans les syntheses stereoselectives et convergentes de l'epa et du dha. Enfin, aucune etude systematique n'ayant ete realisee a ce jour, nous tenterons de definir un moyen simple pour permettre l'attribution des deplacements chimiques des atomes de carbone ethyleniques en rmn du carbone 13
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Hubert, Florence. "Synthèse enzymatique de phospholipides structurés riches en DHA." Thesis, Le Mans, 2018. http://www.theses.fr/2018LEMA1009/document.

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Ce travail étudie l’obtention de phospholipides structurés enrichis en DHA et en acide caprylique (PC DHA-C8) par voie enzymatique. Deux voies de synthèse sont étudiées, l’acidolyse et l’estérification. Suite à un criblage enzymatique, la lipase retenue pour les deux voies de synthèse est TL-IM. Une optimisation des paramètres de la réaction d’acidolyse a été réalisée entre l’acide caprylique (C8:0) et la phosphatidylcholine de tournesol (PC) par le biais d’un plan d’expériences. Les conditions optimales déterminées sont une température de 38°C, une activité de l’eau de 0,7, une quantité d’enzyme de 15% de la masse en substrat ainsi qu’un rapport molaire C8:0/PC de 18. Ces conditions ont ensuite été utilisées pour l’acidolyse de phospholipides microalgaux riches en DHA issus de la microalgue Tisochrysis lutea afin d’obtenir de la PC DHA-C8. Les résultats n’ont pas été concluants. L’autre voie de synthèse étudiée est l’estérification par des lipases de la GPC, de l’acide caprylique et du DHA en milieu fondu. Cette réaction a été optimisée par la technique du pas par pas. Les paramètres étudiés sont la température, la quantité d’enzyme, le rapport molaire GPC/C8:0/DHA et l’application d’un vide. Pour l’obtention de PC DHA-C8, il faut fixer chacun de ces paramètres respectivement de la sorte : 45°C, 20% d’enzyme, un rapport molaire de 1/3/15 et un vide de 100 mbar. La production de PC DHA-C8, bien qu’optimisée ne dépasse pas 2% de rendement. Cependant, durant cette expérience, il a été constaté une forte production de LPC DHA, atteignant 16% sans optimisation des paramètres de synthèse
The enzymatic synthesis of structured phsopholipids enriched in DHA and caprylic acid (PC DHA-C8) is studied. Two different ways are studied, acidolysis and esterification. An enzymatic screening led to the choice of the immobilized lipase from Thermomyces lanuginosa (TL-IM) for the 2 reactions. Parameters of the acidolysis reaction between carpylic acid (C8:0) and sunflower phosphatidylcholine (PC) were optimized by means of an experimental design. The optimum conditions determined are a temperature of 38°C, an aw of 0.7, an amount of enzyme of 15% of the mass of substrate and a molar ratio of C8:0/PC of 18. These conditions were applied to the acidolysis of microalgal phospholipids from T. lutea, rich in DHA, in order to produce PC DHA-C8. The other studied reaction is the lipase catalyzed esterification of GPC with C8:0 and DHA in a solvent-free medium This reaction has been optimized by studying each factor independently. The parameters studied are the temperature, the amount of lipase, the molar ratio GPC/C8:0/DHA and the use of reduced pressure. In order to obtain PC DHA-C8, each of theses parameters are respectively set at: 45°C, 20% of enzyme, a molar ratio of 1/3/15 and a pressure of 100 mbar. The production of PC DHA-C8, although optimized, does not exceed a yield of 2%. However, during this experiment, a high production of LPC DHA is observed, up to 16% without optimization of the synthesis parameter
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Malcolm, Cari A. "Maternal docosahexaenoic acid (DHA) supplementation and infant visual development." Thesis, Glasgow Caledonian University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270513.

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Books on the topic "DHA"

1

Dha śêḍo. Rājakoṭa: Pravīṇa Prakāśana Prā. Li, 2016.

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Paṇḍyā, Pradīpa. Dha ḍôkaṭarsa. Mumbaī: Āra. Āra. Śeṭhanī Kampanī, 2002.

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Paṇḍyā, Pradīpa. Dha hôspiṭala. Mumbai: Āra. Āra. Śeṭhanī Kampanī, 1996.

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Mahetā, Ilā Āraba. Dha nyū lāīpha. Amadāvāda: Gūrjara Grantharatna Kāryālaya, 2004.

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Śāha, Nareśa. Paṭela, dha leṇḍalorḍa. Rajakota: Nyujavala Midiya, 2009.

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translator, Jaya Cirāga Ṭhakkara, ed. Dha rojhebala lāina. Amadāvāda: Navabhārata Sāhitya Mandira, 2017.

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Puvāra, Indu. Veva-dha veva. Amadāvāda: Rannāde Prakāśana, 2000.

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Śāha, Nareśa. Paṭela, dha leṇḍalorḍa. Rajakota: Nyujavala Midiya, 2009.

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Śāha, Nareśa. Paṭela, dha leṇḍalorḍa. Rajakota: Nyujavala Midiya, 2009.

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Śāha, Nareśa. Paṭela, dha leṇḍalorḍa. Rajakota: Nyujavala Midiya, 2009.

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Book chapters on the topic "DHA"

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Upchurch Sweeney, C. Renn, J. Rick Turner, J. Rick Turner, Chad Barrett, Ana Victoria Soto, William Whang, Carolyn Korbel, et al. "DHA." In Encyclopedia of Behavioral Medicine, 575. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-1005-9_100461.

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Gooch, Jan W. "DHA." In Encyclopedic Dictionary of Polymers, 203. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_3475.

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Clauss, Nikki, and Ashley Rankin. "Docosahexaenoic Acid (DHA)." In Encyclopedia of Evolutionary Psychological Science, 1–5. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-16999-6_743-1.

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Clauss, Nikki, and Ashley Rankin. "Docosahexaenoic Acid (DHA)." In Encyclopedia of Evolutionary Psychological Science, 2073–78. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-319-19650-3_743.

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Anshel, Jeffrey. "DHA, EPA, and Ocular Health." In Omega-6/3 Fatty Acids, 89–101. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-215-5_7.

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Speth, John D. "DHA and the Developing Brain." In The Paleoanthropology and Archaeology of Big-Game Hunting, 135–47. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-6733-6_11.

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Metze, Dieter, Tam Nguyen, Birgit Haack, Alexander K. C. Leung, Noriko Miyake, Naomichi Matsumoto, A. J. Larner, et al. "2,8-Dihydroxyadenine (2,8-DHA) Urolithiasis." In Encyclopedia of Molecular Mechanisms of Disease, 535. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_7271.

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Lien, Eric L. "DHA in the Second 6 Months of Life." In Omega-6/3 Fatty Acids, 79–87. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-215-5_6.

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Haraldsson, Gudmundur G. "Enrichment of Lipids with EPA and DHA by Lipase." In Enzymes in Lipid Modification, 170–89. Weinheim, FRG: Wiley-VCH Verlag GmbH & Co. KGaA, 2005. http://dx.doi.org/10.1002/3527606033.ch10.

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Schmidhammer, U., V. De Waele, G. Buntinx, and E. Riedle. "From ultrafast spectroscopy to bidirectional molecular switches: DHA/VHF." In Springer Series in Chemical Physics, 465–67. Berlin, Heidelberg: Springer Berlin Heidelberg, 2005. http://dx.doi.org/10.1007/3-540-27213-5_142.

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Conference papers on the topic "DHA"

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Bingöl, Cemile, and Özlem Çağındı. "Beslenmede DHA ve EPA’ nın Önemi ve Biyoerişilebilirliği." In 6th International Students Science Congress. Izmir International Guest Student Association, 2022. http://dx.doi.org/10.52460/issc.2022.024.

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Vücudun üretemediği ve diyet yoluyla alınması gereken elzem yağ asitleri 18 karbonlu ve 3 çift bağ içeren α-linolenik asit (ALA, 18:3) ve 18 karbon atomlu ve iki çift bağ içeren linoleik asittir (LA, 18:2). Alfa-linolenik asitten sentezlenen eikosapentaenoik asit (EPA, 20:5, n-3) ve dokosaheksaenoik asit (DHA, 22:6, n-3) büyüme ve normal hücresel işlevler için elzem besin ögeleridir. DHA, sinir sisteminin ve retinanın normal gelişimi için gereklidir. Hamilelik sırasında ve erken çocukluk döneminde fetal beyin ve retinada birikir. Beyinde bulunan gri madde olarak adlandırılan bölge, merkezi sinir sisteminin başlıca bileşenlerinden biridir ve zihinsel aktivitelerin gerçekleştiği kısımdır. Beyin yapısı ve işlevlerine esas etkileri ise nöron membranlarının akışkanlığını sağlaması, beyinin nörotransmitterlerinin sentezi ve fizyolojik işlevlerinde rol almasıdır. Ayrıca, her iki bileşen de ateroskleroz, yaşlanma, kalp krizi, felç, hipertansiyon, hamileliği destekleme ve erken yaşam metabolizmasında hayati önem taşıyan çok sayıda hastalığın önlenmesinde kilit unsurlardır. Yapılan çalışmalarda EPA’nın trombositlerin damarlarda kümeleşme ve pıhtı oluşturmasını engellediği ve kan basıncının düşürdüğü, kalsiyumun emilimini ve kemiklerde depolanmasını sağlayarak kemiklerde Ca yoğunluğunu yükselttiği ve özellikle yaşlılık döneminde görülen osteoporoz (kemik erimesi) oluşumunu engellediği belirtilir. DHA ve EPA’nın zihinsel gelişim ve aktivitesi üzerindeki etkisi, kardiyovasküler hastalıkları tedavi ve önlemedeki etkileri ve daha birçok faydasından dolayı insan diyetinde büyük bir öneme sahiptir. Sağlıklı beslenme için besinlerin sadece içerik ve miktarı değil, aynı zamanda o besin öğesinin biyoerişilebilirliği de oldukça önemlidir. Biyoerişilebilirlik, vücuda alınan gıdanın sindirildikten sonra içerisindeki besin öğelerinin gıda matriksinden çıkabilen ve ince bağırsakta emilim için hazır bulunan miktarıdır. Özellikle başta beyin fonksiyonlarının gelişimi olmak üzere, birçok hayati fonksiyonlardaki önemimden dolayı besin öğelerinin içeriğinde yer alan EPA ve DHA miktarı ve biyoerişilebilirliği sağlıklı gelişim ve yaşam için kritik önem arz etmektedir. EPA ve DHA' nın ortak besin kaynakları genellikle soğuk denizlerde yaşayan; uskumru, somon, ton balığı, ringa balığı ve sardalya gibi yağlı balıklardır. Ayrıca EPA ve DHA, alfa-linolenik asit (ALA) açısından zengin, yapraklı sebzeler, kanola yağları, lahana, ceviz, keten tohumu yağı gibi bitki kaynaklarından elde edilen kısa zincirli yağ asidi omega-3 formundan da elde edilebilir. EPA ve DHA bileşenlerinin biyoerişilebilirliği hakkında yapılan çalışmalar oldukça sınırlı olmakla birlikte bu durum bu alanda daha fazla çalışmaya ihtiyaç olduğunu göstermektedir. Bu çalışmada, beslenmede DHA ve EPA’nın vücuttaki fonksiyonları, emilim mekanizması, farklı gıda matrislerinin ve gıda işlemenin DHA ve EPA’nın biyoerişilebilirliği ve biyoyararlılığı ile sağlık üzerine etkileri yapılan kapsamlı literatür taramasıyla incelenerek derlenmiştir.
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Dhavamani, Sugasini, Papasani V. Subbaiah, and Poorna CR Yalagala. "Enrichment of brain DHA through dietary LPC EPA/ DHA- Potential application for the Alzheimer disease." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/kemo3939.

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DHA (docosahexaenoic acid,22:6, n-3) is uniquely concentrated in the brain and is critical for normal development and function of the brain. DHA deficiency contributes to several neurological diseases including Alzheimer's disease (AD), whereas high dietary intake of DHA is negatively associated with incidence of AD. However, clinical trials using fish oil for improving memory in AD patients and animal models were unsuccessful. We propose that this failure is due to inability of currently available supplements to enrich brain DHA because they are absorbed as triacylglycerol which cannot cross blood brain barrier (Fig. 1). We recently demonstrated that DHA content of the brain can be nearly doubled in normal adult mice, and that their brain function markedly improved, by gavaging low doses (0.04g/kg bw) of lysophosphatidylcholine (LPC)-DHA. This is because LPC escapes degradation by pancreatic enzymes, and is taken up by brain through the Mfsd2a pathway (Fig. 1). Here we tested the hypothesis that brain DHA in AD mice can be enriched by dietary LPC-EPA/DHA and thereby prevent or delay the development of AD. LPC-EPA/DHA was prepared by lipase treatment of krill oil and blended with rodent chow to yield the final EPA/DHA concentration of 0.35g/kg diet and fed to 5XFAD mice for 6 months, starting at the age of 1month.Control group was fed fish oil containing EPA/DHA at the same dose in the form of TAG. Our results showed that LPC DHA/EPA significantly increased brain DHA in both male (+118%) and female (+127%) 5XFAD mice as compared to TAG DHA/EPA. LPC DHA/EPA also increases significantly brain EPA in both male (40-fold) and female (50-fold) 5XFAD mice as compared to TAG DHA/EPA. These studies could provide a novel nutraceutical approach for enriching brain DHA and for the prevention and treatment of Alzheimer's disease and other neuroinflammatory diseases.
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Bazinet, Richard. "New methods using natural abundance carbon isotope ratio analysis to measure the turnover of docosahexaenoic acid in preclinical models." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/aloq1878.

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Recently, our laboratory has explored an alternative and cost-effective technique called compound-specific isotope analysis by gas-chromatography isotope ratio mass spectrometry that takes advantage of natural differences in carbon-13 content (13C/12C ratio or d13C) of the food supply to better understand tissue DHA metabolism. However, a lack of variation in the d13C of some molecules limits the methods utility. Here I will present two novel approaches that can be used to circumvent this limitation. Alpha-linolenic acid (ALA), is a well know precursor to docosahexaenoic acid, but it is difficult to find ALA from sources with different d13C. In the first study we fed mice DHA sourced from algae (enriched in carbon 13) chronically and then switched the mice to less enriched fatty acid sources including ALA from flaxseed oil, ALA and stearidonic acid (SDA) from ahiflower oil or DHA derived from fish oil. We show that DHA tissue turnover can be measured from dietary ALA, ALA and SDA or DHA. In the second study upon chronically feeding mice DHA obtained from fish oil we switched mice to a diet either spiked with a small amount (~0.03%) of uniformly labeled DHA to increase the d13C of DHA or to DHA derived from algae. Not only could we differentiate the sources of DHA in the tissues, but the different sources of DHA produced similar tissue half lives. In conclusion, limitations in the natural variance of d13C can be circumvented by changing the d13C content of metabolic products or by adding small amounts of labelled molecules to increase the d13C content.
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Jackson, Kristina, and Nayomi Plaza. "Challenges in proposing omega-3 fatty acid recommendations for the public." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/fgey5940.

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Long-chain omega-3 fatty acids, eicosapentaenoic and docosahexaenoic acids (EPA, DHA), are important nutrients, but they do not have a Dietary Reference Intake (DRI) recommendation. This lack of recognition as essential nutrients makes it difficult to set population guidelines for EPA and DHA (like the Dietary Guidelines for Americans). Challenges in proposing EPA and DHA recommendations for the public are mainly determining which health outcomes reflect a €œdeficiency€ for EPA and DHA and defining the EPA and DHA dose recommendation for the general public and at each life stage. The modernization of the DRI process to redefine what €œpreventing deficiency€ means for each nutrient includes allowing the use of chronic health conditions as signs of deficiency, which may be the path by which EPA and DHA will receive a DRI. A circulating biomarker that links EPA and DHA intake with chronic disease risk is the Omega-3 Index, defined as the proportion of EPA and DHA of total erythrocyte fatty acids. An Omega-3 Index of 8% has been shown to be associated with lower risk of cardiovascular disease and an index of less than 4% is associated with higher risk, and these benchmarks could provide a standard to which intake recommendations could be set. There is evidence that around 50% of the US and Canadian populations are less than 4% and efforts to improve omega-3 status and intake in this population may be the most important for population health, especially for pregnant women. The EPA and DHA dose needed to reach an 8% target from 4% is higher than what can reasonably be achieved through diet (1.4-2.2 g/d; daily fish intake); however, aiming to prevent deficiency, or increase the Omega-3 Index above 4% would be more in line with current recommendations (200-300 mg/d; 2 servings of omega-3-rich fish per week).
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Lim, Kyu, Kaipeng Jing, Soyeon Shin, Soyeon Jeong, Soyeon Kim, Gi-Ryang Kweon, Seung-Kiel Park, Tong Wu, and Jong-Il Park. "Abstract 2255: DHA may enhance proteasome activity in human cervical cancer cells: Indirect modulation of proteasome by DHA." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-2255.

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URAKAZE, M., T. HAMAZAKI, S. SAWAZAKI, K. YAMAZAKI, M. FUJIKAWA, and S. YANO. "PROTECTION FROM ARACHIDONIC ACID-INDUCED SUDDEN DEATH BY INJECTION OF TRIDOCOSAHEXAENOYL-GLYCEROL EMULSION INTO RABBITS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643394.

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An injectable emulsion of docosahexaenoic acid (DHA) was prepared. One hundred ml of the emulsion contained 3g of 93%-pure 1,2,3-tridocosahexaenoy1-glycerol (DHA-TG), 1.2g of 93%-pure 2-docosahexaenoyl-phosphatidylcholine as an emulsifier and 2.5g of glycerol. Thirty ml of the emulsion of DHA-TG was injected into rabbits on days 1 and 4 of the study. Blood was taken on day 0, on day 4 just before the second injection, and on day 7. The percent of DHA in the total phospholipid fraction of platelets was increased from 0.46% (day 0) to 1.88% (day 4, p<0.05) and 3.66% (day 7; p<0.02 vs day 0); that of eicosapentaenoic acid (EPA) was increased from 0.46% (day 0) to 1.03% (day 4, p<0.02) and 1.63% (day 7; p< 0.05 vs day 0); that of arachidonic acid (AA) was decreased from 9.45% (day 0) to 4.31% (day 4, p<0.05) and 6.68% (day 7; p<0.02 vs day 0). The percent of DHA in the total phospholipid fraction of erythrocyte membranes was increased from 0.23% (day 0) to 0.91% (day 4, p<0.05) and 1.52% (day 7; p<0.005 vs day 0); that of EPA was increased from 0.21% (day 0) to 0.34% (day 4, p<0.005) and 0.52% (day 7, p<0.01 vs day 0); that of AA was unchanged at all. Blood lipids were the same before and after the two injections of the emulsion, except that free fatty acids decreased markedly from 0.32 to 0.06 mEq/1 (p<0.02). On day 8, free AA (2 mg/Kg) was injected into ear veins of the treated three rabbits and also into those of four control rabbits, which were not treated with DHA-TG. All the control rabbits died a few minutes after the AA injection but none of DHA-treated rabbits died after AA injection (p<0.01). An emulsion of DHA-TG may be useful for patients having immediate risk of thrombosis or for those who need DHA but cannot take it orally.
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SHAO, Wenyao, Mengwen YAN, Quanling XIE, and Xueshan PAN. "Microencapsulation of DHA Algal Oil by Spray Drying." In International Conference on Biological Engineering and Pharmacy 2016 (BEP 2016). Paris, France: Atlantis Press, 2017. http://dx.doi.org/10.2991/bep-16.2017.17.

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Hernandez Barrueta, Tana, Ameer Taha, and Nitin Nitin. "Intact milk fat globules as a dynamic encapsulation matrix for DHA, which in situ produces DHA-derived anti-inflammatory lipids." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/lkgi4599.

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Supplementation with docosahexaenoic acid (DHA) is proposed as a nutritional intervention to address diseases associated with chronic inflammation, partially owing to its -enzymatically- oxidized products such as epoxydocosapentaenoic acid (EpDPE). Nevertheless, the slow in vivo turnover of DHA to EpDPE might narrow the effectiveness of this approach, leading us to speculate that delivering EpDPE directly could overcome this limitation. We hypothesized that encapsulating DHA into milk fat globules would yield EpDPE, considering the membrane surrounding the globules originates from the epithelial cells in the mammary glands, which contain the enzyme that catalyzes such reaction cytochrome P450. To test this, we first encapsulated DHA into milk fat globules isolated from raw bovine milk, via passive diffusion at room temperature or 4 °C. Then, we quantified free and total oxylipins using ultra-high performance liquid chromatography coupled to tandem mass spectrometry. All five EpDPE targeted [19(20), 16(17), 13(14), 10(11) and 7(8)-EpDPE] were found to be produced. The most abundant one, 19(20)-EpDPE, reached 2.6-2.0 pmol/mg of milk cream after 30 min at the temperatures tested; from this, 40% was in free form and the remaining 60% esterified (i.e. bounded). To the best of our knowledge, this data is the first report of an active cytochrome P450 with epoxidase activity in the milk fat globule from raw bovine milk. Altogether, our results advocate for the use of milk fat globules as a naturally-occurring encapsulation system capable of, upon encapsulation, converting DHA into bioactive lipids with anti-inflammatory properties.
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Linderborg, Kaisa, Annelie Damerau, and Eija Ahonen. "Stability of omega-3 fatty acids in different lipid forms analyzed by SPME-GC-MS, NMR and loss of antioxidants." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/gqky3982.

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The dietary intake of marine foods is globally inadequate, and thus supplements with long-chain omega-3 fatty acids are widely used. Both the source and processing choices affect the lipid class (most typically triacylglycerols (TAGs), ethyl esters (EEs), or phospholipids (PLs)) in which docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are present, and thus consumed.Here we present investigation of the effect of lipid type on oxidation by the analysis of oxidation products of commercial supplements including EPA and DHA in different lipid forms, as well as results of an oxidation trial of pure DHA-containing TAGs and EEs in the presence and absence of alpha-tocopherol. We also present the applicability of SPME-GC-MS and NMR methods as well as analysis of the loss of antioxidants as alternative methods to peroxide (PV) and para-anisidine values (PAV). PAV typically has challenges with aroma compounds present and the reliability of PV is decreased by different formation and decomposition rates of hydroperoxides under different conditionsIncreased lipid oxidation was detected in 24% of the studied omega-3 supplements, which were in either TAG or EE form. 1H NMR was found to be a potential rapid method for lipid class determination and was applicable in detecting products of oxidation through selective pulse experiments. Analysis of volatile secondary oxidation products with SPME-GC-MS may be a future alternative to PAV analysis of especially flavored products when standardized. 2,4-Heptadienal, 1-penten-3-ol, and 2-hexenal showed the highest potential to be used as indicator compounds for lipid oxidation in products high in EPA and DHA content. Oxidative stability, oxidation pattern, and α-tocopherol response of DHA were influenced by the lipid structure (TAG/EE). DHA in EE form was found to be more stable than DHA in TAG form in the presence of α-tocopherol, but the opposite was observed without the antioxidant.
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Oguro, Ami, and Yasuhiro Ishihara. "Role of DHA metabolites in protective effects of DHA supplementation in the brains of rotenone-induced rat models of Parkinson’s disease." In 1st International Electronic Conference on Biomolecules: Natural and Bio-Inspired Therapeutics for Human Diseases. Basel, Switzerland: MDPI, 2020. http://dx.doi.org/10.3390/iecbm2020-08583.

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Reports on the topic "DHA"

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Borgonovi, Sara Margherita, Stefania Iametti, and Mattia Di Nunzio. Docosahexaenoic acid as master regulator of cellular antioxidant defenses: a systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, June 2023. http://dx.doi.org/10.37766/inplasy2023.6.0017.

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Review question / Objective: Evaluate the potential effect of DHA in regulating cellular antioxidant enzymes and hypothesizes possible molecular scenarios between DHA and Nrf2 in regulating cellular antioxidant defenses. Eligibility criteria: Chosen studies were published between 1998 and 2021 without restriction regarding pe-riod or publication status. Exclusion criteria were: (i) titles irrelevant to the research topic; (ii) abstract inappropriate or not related to the research topic; (iii) studies that used n-3 PUFAs rich oils which not allowed to discriminate the effect of DHA from other n-3 PUFAs; (iv) studies that co-administrated DHA with other compounds; (v) studies that used DHA oxidation products to better reflect normal nutritional conditions (vi) studies or data with inadequate statistical analysis or inappropriate control. Reviews, letters, ab-stracts, and articles without a complete text in the English language were also excluded.
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Food Standards Agency. Safety Assessment RP1411 Schizochytrium sp. oil rich in DHA and EPA. Food Standards Agency, April 2024. http://dx.doi.org/10.46756/sci.fsa.pao657.

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This section summarises outcome of assessment of an application under the assimilated regulation 2015/2283 EU for Schizochytrium sp. oil rich in DHA and EPA as a novel ingredient in meat and fish analogues.
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Gu, Yongwen. The Effect of Docosahexaenoic Acid (DHA)-Containing Phosphatidylcholine (PC) on Liquid-Ordered and Liquid-Disordered Coexistence. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.1949.

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Nico, Bravo, and Lurdes Pratas Nico. Dia da Universidade Sénior Túlio Espanca/Escola Popular da Universidade de Évora. Universidade Popular Túlio Espanca da Universidade de Évora (UPTE/UÉ), 2011. http://dx.doi.org/10.5935/ref.20160116.

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Feres Júnior, João. Folha padrão Veja: o DNA marrom da mídia brasileira. Universidade do Estado do Rio de Janeiro, October 2014. http://dx.doi.org/10.12957/manchetrometro.2014.0007.

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Feres Júnior, João, Fernanda Cavassana, André Madruga, and Lidiane Vieira. Olhar crítico em relação a Lava Jato: uma homenagem da Folha ao dia da mentira. Universidade do Estado do Rio de Janeiro, April 2021. http://dx.doi.org/10.12957/manchetrometro.2021.0007.

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Martins, Vitoria, José Bitencourt, Gisele Nunes, Renato Oliveira, Santelmo Vasconcelos, Paulo Costa, and Guilherme Oliveira. Manual para monitoramento da flora por meio de DNA ambiental - eDNA. ITV DS, 2021. http://dx.doi.org/10.29223/prod.tec.itv.ds.n023.2020.martins.

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Os esforços para a construção de um banco de dados genético com códigos de barra de DNA das espécies da Flora de Carajás possibilitaram obter “impressões digitais” das espécies que ali ocorrem. A partir do banco de dados de referência criado pelo ITV, o ITVBiobase, outras tecnologias moleculares como a de DNA metabarcoding pode ser aplicada visando o monitoramento das espécies de forma rápida, automatizada e eficiente. A técnica de DNA metabarcoding possibilita identificar simultaneamente múltiplas espécies de plantas a partir dos rastros de DNA presente em uma amostra ambiental, descartando a necessidade de amostragem direta de espécimes. Nesse sentido, estudos para validação do uso da técnica de DNA metabarcoding para monitoramento da biodiversidade da flora em Carajás, foram realizados com o objetivo de criar um manual padronizado incluindo as etapas desde a coleta em campo até as análises laboratoriais e de bioinformática.
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Candido, Marcia Rangel, Natasha Bachini, and João Feres Júnior. Convictos, retrocedemos: o dia da mulher, Temer e a cobertura midiática. Universidade do Estado do Rio de Janeiro, April 2017. http://dx.doi.org/10.12957/manchetrometro.2017.0001.

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Costa, Paulo, Gisele Nunes, Vitória Martins, Renato Oliveira, José Bitencourt, and Guilherme Oliveira. Manual para o monitoramento da ictiofauna por meio de DNA ambiental (eDNA). ITV DS, 2021. http://dx.doi.org/10.29223/prod.tec.itv.ds.2020.24.costa.

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A ictiofauna amazônica é composta por uma enorme diverdidade de peixes sendo muitas espécies de ocorrência local. Programas de conservação e monitoramento são muitas vezes dificultados tanto pela falta de especialistas quanto pela dificuldade da captura dos espécimes. A criação de indicadores biológicos é de suma importância principalmente para mineração, que necessita realizar monitoramento periódico para verificar se suas atividades estão ou podem causar impactos sob a diversidade ao entorno do empreendimento. Na Serra dos Carajás, um dos maiores depósitos mineral do mundo, existem lagoas que demandam monitoramento devido suas peculariedades e possibilidades de impactos. Essas lagoas são formadas sob crostas lateríticas ricas em ferro, em platôs acima de 770 m acima do nível do mar, no qual o nível de água é mantido pelo do regime de chuvas da região. Pensando em estratégias de manejo mais eficientes e rápidos, este trabalho teve como objetivo validar uma nova abordagem de levantamento de biodiversidade da ictiofauna utilizando os rastros de DNA presentes no ambiente. Para isso, foi usado a técnica de DNA metabarcoding que permite avaliar a diversidade e riqueza de espécies sem necessidade de captura, e sim através da análise de pequenos fragmentos de DNA a partir de uma amostras ambiental, como água ou sedimentos dos rios e lagoas.
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10

Gölles, Markus, Daniel Muschick, Viktor Unterberger, Paolo Leoni, Ralf-Roman Schmidt, and Gunnar Lennermo. Control of DHC networks and Reduction of the operating temperatures in DH systems. IEA SHC Task 55, January 2021. http://dx.doi.org/10.18777/ieashc-task55-2021-0002.

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Overview on different approaches for the control of the heat distribution networks in case of the integration of large-scale solar thermal systems, and different possibilities for the reduction of the operating temperatures in DH systems.
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