Relevant bibliographies by topics / Detoxification enzymes

Academic literature on the topic 'Detoxification enzymes'

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Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Detoxification enzymes"

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Barrett, J. "Helminth detoxification mechanisms." Journal of Helminthology 71, no. 2 (June 1997): 85–90. http://dx.doi.org/10.1017/s0022149x0001573x.

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Detoxification mechanisms in parasitic helminths have not been extensively studied, despite their obvious relevance to drug development and drug resistance. Differences in detoxification enzymes between the parasite and its host may be exploitable in the design of pro-drugs, whilst selective inhibition of the parasites protective enzymes could increase their sensitivity to drug action and also make them more susceptible to the host's defence mechanisms.
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Guan, Yun, Jia Chen, Eugenie Nepovimova, Miao Long, Wenda Wu, and Kamil Kuca. "Aflatoxin Detoxification Using Microorganisms and Enzymes." Toxins 13, no. 1 (January 9, 2021): 46. http://dx.doi.org/10.3390/toxins13010046.

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Mycotoxin contamination causes significant economic loss to food and feed industries and seriously threatens human health. Aflatoxins (AFs) are one of the most harmful mycotoxins, which are produced by Aspergillus flavus, Aspergillus parasiticus, and other fungi that are commonly found in the production and preservation of grain and feed. AFs can cause harm to animal and human health due to their toxic (carcinogenic, teratogenic, and mutagenic) effects. How to remove AF has become a major problem: biological methods cause no contamination, have high specificity, and work at high temperature, affording environmental protection. In the present research, microorganisms with detoxification effects researched in recent years are reviewed, the detoxification mechanism of microbes on AFs, the safety of degrading enzymes and reaction products formed in the degradation process, and the application of microorganisms as detoxification strategies for AFs were investigated. One of the main aims of the work is to provide a reliable reference strategy for biological detoxification of AFs.
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Guan, Yun, Jia Chen, Eugenie Nepovimova, Miao Long, Wenda Wu, and Kamil Kuca. "Aflatoxin Detoxification Using Microorganisms and Enzymes." Toxins 13, no. 1 (January 9, 2021): 46. http://dx.doi.org/10.3390/toxins13010046.

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Mycotoxin contamination causes significant economic loss to food and feed industries and seriously threatens human health. Aflatoxins (AFs) are one of the most harmful mycotoxins, which are produced by Aspergillus flavus, Aspergillus parasiticus, and other fungi that are commonly found in the production and preservation of grain and feed. AFs can cause harm to animal and human health due to their toxic (carcinogenic, teratogenic, and mutagenic) effects. How to remove AF has become a major problem: biological methods cause no contamination, have high specificity, and work at high temperature, affording environmental protection. In the present research, microorganisms with detoxification effects researched in recent years are reviewed, the detoxification mechanism of microbes on AFs, the safety of degrading enzymes and reaction products formed in the degradation process, and the application of microorganisms as detoxification strategies for AFs were investigated. One of the main aims of the work is to provide a reliable reference strategy for biological detoxification of AFs.
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Cohen, Martin R., C. N. Ramchand, Voyta Sailer, Maria Fernandez, William McAmis, N. Sridhara, and Cornelius Alston. "Detoxification enzymes following intrastriatal kainic acid." Neurochemical Research 12, no. 5 (May 1987): 425–29. http://dx.doi.org/10.1007/bf00972293.

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Lyagin, Ilya, and Elena Efremenko. "Enzymes for Detoxification of Various Mycotoxins: Origins and Mechanisms of Catalytic Action." Molecules 24, no. 13 (June 26, 2019): 2362. http://dx.doi.org/10.3390/molecules24132362.

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Mycotoxins are highly dangerous natural compounds produced by various fungi. Enzymatic transformation seems to be the most promising method for detoxification of mycotoxins. This review summarizes current information on enzymes of different classes to convert various mycotoxins. An in-depth analysis of 11 key enzyme mechanisms towards dozens of major mycotoxins was realized. Additionally, molecular docking of mycotoxins to enzymes’ active centers was carried out to clarify some of these catalytic mechanisms. Analyzing protein homologues from various organisms (plants, animals, fungi, and bacteria), the prevalence and availability of natural sources of active biocatalysts with a high practical potential is discussed. The importance of multifunctional enzyme combinations for detoxification of mycotoxins is posed.
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Kotze, Andrew C., Angela P. Ruffell, and Aaron B. Ingham. "Phenobarbital Induction and Chemical Synergism Demonstrate the Role of UDP-Glucuronosyltransferases in Detoxification of Naphthalophos by Haemonchus contortus Larvae." Antimicrobial Agents and Chemotherapy 58, no. 12 (October 6, 2014): 7475–83. http://dx.doi.org/10.1128/aac.03333-14.

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ABSTRACTWe used an enzyme induction approach to study the role of detoxification enzymes in the interaction of the anthelmintic compound naphthalophos withHaemonchus contortuslarvae. Larvae were treated with the barbiturate phenobarbital, which is known to induce the activity of a number of detoxification enzymes in mammals and insects, including cytochromes P450 (CYPs), UDP-glucuronosyltransferases (UDPGTs), and glutathione (GSH)S-transferases (GSTs). Cotreatment of larvae with phenobarbital and naphthalophos resulted in a significant increase in the naphthalophos 50% inhibitory concentration (IC50) compared to treatment of larvae with the anthelmintic alone (up to a 28-fold increase). The phenobarbital-induced drug tolerance was reversed by cotreatment with the UDPGT inhibitors 5-nitrouracil, 4,6-dihydroxy-5-nitropyrimidine, probenecid, and sulfinpyrazone. Isobologram analysis of the interaction of 5-nitrouracil with naphthalophos in phenobarbital-treated larvae clearly showed the presence of strong synergism. The UDPGT inhibitors 5-nitrouracil, 4,6-dihydroxy-5-nitropyrimidine, and probenecid also showed synergistic effects with non-phenobarbital-treated worms (synergism ratio up to 3.2-fold). This study indicates thatH. contortuslarvae possess one or more UDPGT enzymes able to detoxify naphthalophos. In highlighting the protective role of this enzyme group, this study reveals the potential for UDPGT enzymes to act as a resistance mechanism that may develop under drug selection pressure in field isolates of this species. In addition, the data indicate the potential for a chemotherapeutic approach utilizing inhibitors of UDPGT enzymes as synergists to increase the activity of naphthalophos against parasitic worms and to combat detoxification-mediated drug resistance if it arises in the field.
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Reed, Lindsay, Volker M. Arlt, and David H. Phillips. "The role of cytochrome P450 enzymes in carcinogen activation and detoxication: an in vivo–in vitro paradox." Carcinogenesis 39, no. 7 (May 3, 2018): 851–59. http://dx.doi.org/10.1093/carcin/bgy058.

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Cytochrome P450 enzyme systems have been widely used in vitro to determine the pathways of activation of procarcinogens, but paradoxically, these same enzymes can play a more predominant role in carcinogen detoxification in vivo.
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Mahmood, Shahid, Azeem Khalid, Muhammad Arshad, Tariq Mahmood, and David E. Crowley. "Detoxification of azo dyes by bacterial oxidoreductase enzymes." Critical Reviews in Biotechnology 36, no. 4 (February 10, 2015): 639–51. http://dx.doi.org/10.3109/07388551.2015.1004518.

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Cornell, H. J., W. Doherty, and T. Stelmasiak. "Papaya latex enzymes capable of detoxification of gliadin." Amino Acids 38, no. 1 (January 21, 2009): 155–65. http://dx.doi.org/10.1007/s00726-008-0223-6.

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Belford, Ebenezer J. D., Ulrike Dörfler, Andreas Stampf, and Peter Schröder. "Microsomal Detoxification Enzymes in Yam Bean [Pachyrhizus erosus (L.) Urban]." Zeitschrift für Naturforschung C 59, no. 9-10 (October 1, 2004): 693–700. http://dx.doi.org/10.1515/znc-2004-9-1014.

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Abstract Cytochrome P450s and glutathione-S-transferases (GSTs) constitute two of the largest groups of enzyme families that are responsible for detoxification of exogenous molecules in plants. Their activities differ from plant to plant with respect to metabolism and substrate specificity which is one of the reasons for herbicide selectivity. In the tuber forming yam bean, the legume Pachyrhizus erosus, their activities at the microsomal level were investigated to determine the detoxification status of the plant. The breakdown of the herbicide isoproturon (IPU) to two distinct metabolites, 1-OH-IPU and monodesmethyl-IPU, was demonstrated. GST activity was determined with model substrates, but also by the catalysed formation of the fluorescent glutathione bimane conjugate. This study demonstrates for the first time microsomal detoxification activity in Pachyrhizus and the fluorescence image description of microsomal GST catalysed reaction in a legume.
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Dissertations / Theses on the topic "Detoxification enzymes"

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Boucher, Ian. "Structural studies of enzymes involved in cell detoxification." Thesis, University of York, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437619.

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Chalmers, D. "Chemical carcinogenesis : Studies on detoxification enzymes in somatic cell hybrids." Thesis, University of Nottingham, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371997.

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Labuschagne, Jeanine. "Molecular methods for genotyping selected detoxification and DNA repair enzymes / J. Labuschagne." Thesis, North-West University, 2010. http://hdl.handle.net/10394/4599.

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The emerging field of personalized medicine and the prediction of side effects experienced due to pharmaceutical drugs is being studied intensively in the post genomic era. The molecular basis of inheritance and disease susceptibility is being unravelled, especially through the use of rapidly evolving new technologies. This in turn facilitates analyses of individual variations in the whole genome of both single subjects and large groups of subjects. Genetic variation is a common occurrence and although most genetic variations do not have any apparent effect on the gene product some do exhibit effects, such as an altered ability to detoxify xenobiotics. The human body has a highly effective detoxification system that detoxifies and excretes endogenous as well as exogenous toxins. Numerous studies have proved that specific genetic variations have an influence on the efficacy of the metabolism of pharmaceutical drugs and consequently the dosage administered. The primary aim of this project was the local implementation and assessment of two different genotyping approaches namely: the Applied Biosystems SNaPshot technique and Affymetrix DMET microarray. A secondary aim was to investigate if links could be found between the genetic data and the biochemical detoxification profile of participants. I investigated the approaches and gained insight into which method would be better for specific local applications, taking into consideration the robustness and ease of implementation as well as cost effectiveness in terms of data generated. The final study cohort comprised of 18 participants whose detoxification profiles were known. Genotyping was performed using the DMET microarray and SNaPshot techniques. The SNaPshot technique was used to genotype 11 SNPs relating to DNA repair and detoxification and was performed locally. Each DMET microarray delivers significantly more data in that it genotypes 1931 genetic markers relating to drug metabolism and transport. Due to the absence of a local service supplier, the DMET - microarrays were outsourced to DNALink in South Korea. DNALink generated raw data which was analysed locally. I experienced many problems with the implementation of the SNaPshot technique. Numerous avenues of troubleshooting were explored with varying degrees of success. I concluded that SNaPshot technology is not the best suited approach for genotyping. Data obtained from the DMET microarray was fed into the DMET console software to obtain genotypes and subsequently analysed with the help of the NWU statistical consultation services. Two approaches were followed: firstly, clustering the data and, secondly, a targeted gene approach. Neither of the two methods was able to establish a relationship between the DMET genotyping data and the detoxification profiling. For future studies to successfully correlate SNPs or SNP groups and a specific detoxification profile, two key issues should be addressed: i) The procedure for determining the detoxification profile following substrate loading should be further refined by more frequent sampling after substrate loading. ii) The number of participants should be increased to provide statistical power that will enable a true representation of the particular genetic markers in the specific population. The statistical analyses, such as latent class analyses to cluster the participants will also be of much more use for data analyses and interpretation if the study is not underpowered.
Thesis (M.Sc. (Biochemistry))--North-West University, Potchefstroom Campus, 2011.
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Cheung, Ka-hong. "Chromate toxicity assessment and detoxification by bacteria from the marine environment /." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36249890.

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Cheung, Ka-hong, and 張嘉康. "Chromate toxicity assessment and detoxification by bacteria from the marine environment." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B45015351.

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Whalen, Kristen Elizabeth. "Functional characterization and expression of molluscan detoxification enzymes and transporters involved in dietary allelochemical resistance." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/43228.

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Thesis (Ph. D.)--Joint Program in Oceanography/Applied Ocean Science and Engineering (Massachusetts Institute of Technology, Dept. of Biology; and the Woods Hole Oceanographic Institution), 2008.
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Understanding how organisms deal with potentially toxic or fitness-reducing allelochemicals is important for understanding patterns of predation and herbivory in the marine environment. The ability of marine consumers to tolerate dietary toxins may involve biochemical resistance mechanisms, which increase the hydrophilicity of compounds and facilitate their active efflux out of sensitive cells and tissues. While several allelochemical-responsive detoxification enzymes have been sequenced and functionally characterized in terrestrial invertebrates feeding on chemically defended host plants, there is virtually no information concerning the role of these biotransformation enzymes that may mediate feeding tolerance in marine invertebrates. The objective of this research was to assess the diversity and dietary regulation of cytochrome P450s (CYP), glutathione S-transferases (GST) and ABC transporters in the generalist marine gastropod Cyphoma gibbosum feeding on a variety of chemically defended gorgonian corals, and to identify those dietary natural products that act as substrates for these proteins. Molecular and proteomic techniques identified both allelochemically-responsive CYPs, and constitutively expressed GSTs and transporters in Cyphoma digestive glands. Inhibition of Cyphoma GST activity by gorgonian extracts and selected allelochemicals (i.e., prostaglandins) indicated that gorgonian diets are likely to contain substrates for molluscan detoxification enzymes. In vitro metabolism studies with recombinant CYPs suggested those Cyphoma enzymes most closely related to vertebrate fatty acid hydroxylating enzymes may contribute to the detoxification ofichthyodeterrent cyclopentenone prostaglandins found in abundance in selected gorgonian species.
(cont.) Finally, the presence and activity of multixenobiotic resistance transporters in Cyphoma and the co-occurring specialist nudibranch, Tritonia hamnerorum, suggests these efflux transporters could function as a first line of defense against dietary intoxication. Together, these results suggest marine consumers that regularly exploit allelochemical-rich prey have evolved both general (GST and ABC transporters) and allelochemical-specific (CYP) detoxification mechanisms to tolerate prey chemical defenses.
by Kristen Elizabeth Whalen.
Ph.D.
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Cavka, Adnan. "Biorefining of lignocellulose : Detoxification of inhibitory hydrolysates and potential utilization of residual streams for production of enzymes." Doctoral thesis, Umeå universitet, Kemiska institutionen, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-82486.

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Lignocellulosic biomass is a renewable resource that can be utilized for the production of biofuels, chemicals, and bio-based materials. Biochemical conversion of lignocellulose to advanced biofuels, such as cellulosic ethanol, is generally performed through microbial fermentation of sugars generated by thermochemical pretreatment of the biomass followed by an enzymatic hydrolysis of the cellulose. The aims of the research presented in this thesis were to address problems associated with pretreatment by-products that inhibit microbial and enzymatic biocatalysts, and to investigate the potential of utilizing residual streams from pulp mills and biorefineries to produce hydrolytic enzymes. A novel method to detoxify lignocellulosic hydrolysates to improve the fermentability was investigated in experiments with the yeast Saccharomyces cerevisiae. The method is based on treatment of lignocellulosic slurries and hydrolysates with reducing agents, such as sodium dithionite and sodium sulfite. The effects of treatment with sodium borohydride were also investigated. Treatment of a hydrolysate of Norway spruce by addition of 10 mM dithionite resulted in an increase of the balanced ethanol yield from 0.03 to 0.35 g/g. Similarly, the balanced ethanol yield of a hydrolysate of sugarcane bagasse increased from 0.06 to 0.28 g/g after treatment with 10 mM dithionite. In another study with a hydrolysate of Norway spruce, addition of 34 mM borohydride increased the balanced ethanol yield from 0.02 to 0.30 g/g, while the ethanol productivity increased from 0.05 to 0.57 g/(L×h). While treatment with sulfur oxyanions had a positive effect on microbial fermentation and enzymatic hydrolysis, treatment with borohydride resulted in an improvement only for the microbial fermentation. The chemical effects of treatments of hydrolysates with sodium dithionite, sodium sulfite, and sodium borohydride were investigated using liquid chromatography-mass spectrometry (LC-MS). Treatments with dithionite and sulfite were found to rapidly sulfonate inhibitors already at room temperature and at a pH that is compatible with enzymatic hydrolysis and microbial fermentation. Treatment with borohydride reduced inhibitory compounds, but the products were less hydrophilic than the products obtained in the reactions with the sulfur oxyanions. The potential of on-site enzyme production using low-value residual streams, such as stillage, was investigated utilizing recombinant Aspergillus niger producing xylanase and cellulase. A xylanase activity of 8,400 nkat/ml and a cellulase activity of 2,700 nkat/ml were reached using stillages from processes based on waste fiber sludge. The fungus consumed a large part of the xylose, the acetic acid, and the oligosaccharides that were left in the stillages after fermentation with S. cerevisiae. In another study, the capability of two filamentous fungi (A. niger and Trichoderma reesei) and three yeasts (S. cerevisiae, Pichia pastoris, and Yarrowia lipolytica) to grow on inhibitory lignocellulosic media were compared. The results indicate that the two filamentous fungi had the best capability to utilize different nutrients in the media, while the S. cerevisiae strain exhibited the best tolerance against the inhibitors. Utilization of different nutrients would be especially important in enzyme production using residual streams, while tolerance against inhibitors is desirable in a consolidated bio-process in which the fermenting microorganism also contributes by producing enzymes.
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Belford, Ebenezer Jeremiah Durosimi. "Purification and characterization of xenobiotic detoxification enzymes in Pachyrhizus "yam bean" and their role in agrochemical metabolism." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=970967012.

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Wilson, Nina Marie. "Strategies to detoxify the mycotoxin deoxynivalenol and improve food safety in the U.S." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/77928.

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Mycotoxins are toxic secondary metabolites produced by fungi that are a threat to the health of humans and domestic animals. The most important mycotoxin in the U.S. is deoxynivalenol (DON), which causes symptoms such as vomiting, feed refusal, and weight loss in farm animals. The fungus Fusarium graminearum produces DON in staple crops such as wheat, barley, and corn. It is estimated that the economic losses associated with DON contamination alone exceed $650 million per year in the U.S. New strategies are needed to mitigate DON and improve food safety in the U.S. The overall goal of my research is to discover and employ microorganisms and enzymes to detoxify DON. The specific objectives are to: (1) discover and characterize microorganisms that detoxify DON, (2) use a cell free protein synthesis (CFPS) system to study enzymes that modify DON, (3) engineer yeast to detoxify DON with a metabolic engineering strategy, and (4) deliver a high school unit to teach high school students about mycotoxins in food. In Objective 1, two mixed cultures were identified from environmental samples that converted DON into the less toxic 3-keto-deoxynivalenol (3-keto-DON). In Objective 2, a CFPS system was used to express three known acetyltransferase genes to convert DON to 3-acetyl-DON (3-A-DON). In Objective 3, we identified a potential DON transporter from a library of randomly amplified fragments from the genomes of mixed cultures of microbes isolated from the environment. In Objective 4, we developed and delivered a unique high school unit to educate high school students about potential mycotoxins in food and feed products. The work presented here represents new and improved methods for mitigating mycotoxin contamination in the United States.
Ph. D.
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Lee, Sansan. "The effects of knocking down ROS detoxification enzymes on the Caenorhabditis elegans mutants clk-1(qm30) and isp-1(qm150) /." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101597.

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Caenorhabditis elegans clk-1(qm30) and isp-1(qm150) mutants exhibit highly pleiotropic phenotypes that include slow development and long lifespan. clk-1(qm30) and isp-1(qm150) correspond to loss of function mutations in genes necessary for ubiquinone biosynthesis and complex III electron transport, respectively. Previous research has lead to the hypothesis that altered levels of cellular reactive oxygen species (ROS) may underlie clk-1(qm30) and isp-1(qm150) mutant phenotypes. To test this hypothesis RNA interference (RNAi) by feeding was used to indirectly alter cellular ROS levels by knocking down genes that encode ROS detoxification enzymes. Specifically, genes that detoxify ROS using glutathione or thioredoxin, both of which are important cellular thiol-redox molecules, were knocked down to examine the role of ROS in determining clk-1(qm30) and isp-1(qm150) lifespan, post-embryonic development, and germline development. In summary, knocking down ROS detoxification genes does not severely appear to affect the phenotypes that were studied. ROS detoxification gene knockdowns consistently induced mild decreases in wild type, clk-1(qm30), and isp-1(qm150) lifespan. However, knocking down NAD+-dependent isocitrate dehydrogenases, which are not closely involved in ROS detoxification, similarly affected lifespan, indicating that decreases are not specific to ROS detoxification. Of note, knocking down gcs-1, which is required for glutathione biosynthesis, induced lethal intestinal abnormalities in wild type, c1k-1(qm30), and isp-1(qm150) worms. Overall, findings do not support that low ROS underlies the clk-1(qm30) and isp-1(qm150) mutant phenotypes.
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Books on the topic "Detoxification enzymes"

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Chen, Chang-Hwei. Activation and Detoxification Enzymes. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-1049-2.

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translator, Li Lingyi, ed. Zhou mo xiao su qing duan shi: Mian jin shi! mei yue 2 tian de shen ti chu xiu ji hua. Taibei Shi: Shi bao wen hua chu ban qi ye gu fen you xian gong si, 2014.

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Worrall, Stephen Frederick. An investigation into the association between cytochrome P450 and glutathione S-transferase detoxification enzyme polymorphisms and human oral squamous cell carcinoma. Birmingham: University of Birmingham, 1998.

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Activation And Detoxification Enzymes Functions And Implications. Springer, 2011.

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Chen, Chang-Hwei. Activation and Detoxification Enzymes: Functions and Implications. Springer, 2014.

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Elsa, Reiner, Aldridge W. Norman, Hoskin, Francis C. G., 1922-, Jugoslavenska akadenija znanosti i umjetnosti., International Union of Toxicology, and International Meeting on Esterases Hydrolysing Organophosphorus Compounds (1988 : Dubrovnik, Croatia), eds. Enzymes hydrolysing organophosphorus compounds. Chichester: E. Horwood, 1989.

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Emel, Arinç, Schenkman John B, and Hodgson Ernest 1932-, eds. Molecular and applied aspects of oxidative drug metabolizing enzymes. New York: Plenum Press, 1999.

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(Editor), J. Christopher Hall, Robert E. Hoagland (Editor), and R. M. Zablotowicz (Editor), eds. Pesticide Biotransformation in Plants and Microorganisms: Similarities and Divergences (Acs Symposium Series). An American Chemical Society Publication, 2000.

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E, Hoagland Robert, Hall J. Christopher, Zablotowicz Robert M, and American Chemical Society, eds. Pesticide biotransformation in plants and microorganisms: Similarities and divergences. Washington, D.C: American Chemical Society, 2000.

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1953-, Hall J. Christopher, Hoagland Robert E, Zablotowicz Robert Michael, and American Chemical Society, eds. Pesticide biotransformation in plants and micro-organisms: Similarities and divergences. Washington, D.C: American Chemical Society, 2001.

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Book chapters on the topic "Detoxification enzymes"

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Chen, Chang-Hwei. "Phase I Enzymes." In Activation and Detoxification Enzymes, 25–36. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4614-1049-2_4.

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Chen, Chang-Hwei. "Phase II Enzymes." In Activation and Detoxification Enzymes, 37–48. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4614-1049-2_5.

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Chen, Chang-Hwei. "Inducibility of Metabolizing Enzymes." In Activation and Detoxification Enzymes, 83–90. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4614-1049-2_9.

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Chen, Chang-Hwei. "Induction and Inhibition Compounds." In Activation and Detoxification Enzymes, 91–102. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4614-1049-2_10.

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Chen, Chang-Hwei. "Diets Rich in Enzyme Modulators." In Activation and Detoxification Enzymes, 103–11. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4614-1049-2_11.

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Chen, Chang-Hwei. "Induction of Enzymes for Health Benefits." In Activation and Detoxification Enzymes, 113–21. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4614-1049-2_12.

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Chen, Chang-Hwei. "Sources of Foreign Compounds." In Activation and Detoxification Enzymes, 123–36. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4614-1049-2_13.

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Chen, Chang-Hwei. "Catalytic Reactions of Phase II Enzymes." In Activation and Detoxification Enzymes, 137–44. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4614-1049-2_14.

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Chen, Chang-Hwei. "Catalytic Reactions of Phase II Enzymes." In Activation and Detoxification Enzymes, 145–54. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4614-1049-2_15.

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Chen, Chang-Hwei. "Diversified Classes of Enzyme Modulators." In Activation and Detoxification Enzymes, 155–65. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4614-1049-2_16.

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Conference papers on the topic "Detoxification enzymes"

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Held, David W. "Detoxification enzymes in Japanese beetle adults and larvae: Prospects for management and eradication." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.94991.

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Neeraja, Pabbaraju, and Sujatha K. "Role of Sodium Selenite on Detoxification Enzymes in Liver and Brain Tissues of Albino Rat Under Ammonia Stress." In Annual International Conference on Advances in Biotechnology. Global Science and Technology Forum (GSTF), 2012. http://dx.doi.org/10.5176/2251-2489_biotech20.

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Gogol, Elina V., Guzel I. Gumerova, and Olga S. Egrova. "Approaches to Assessment and Hazard Identification of Dioxins." In Environmental Engineering. VGTU Technika, 2017. http://dx.doi.org/10.3846/enviro.2017.021.

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In the Russian practice in the framework of environmental regulation sanitary measurements to assess the toxicity of the objects of the environment, which are based on the determination of standardized components concentrations and comparing them with the limit value, are widely used. But this approach doesn’t allow assessing the degree of biological hazards for organisms. The biotesting method has been considered for assessing the safety of dioxin-like compounds. Dioxins can be formed out of control in the environment. Ultraviolet radiation accelerates the formation of dioxins, as it enhances the ability of a chemical reaction of chlorine. This phenomenon is well known in Russia, where the chlorination is a standard procedure of water treatment and disinfection of drinking water, and control of the content of chlorophenols is an optional procedure. Simulation of the formation of dioxins in the process of chlorination of water, containing phenolic compounds, was carried out. Process of dioxins transformation in living systems to more toxic metabolites has been described. Enzymes that are involved in detoxification of dioxins have been identified. According to the results of bioassay danger of water samples, containing dioxins, is underestimated, since it doesn’t take into account specific features of metabolism of dioxins in living organisms. Under the action of enzymes in the cells the less toxic compounds can be converted into the more toxic in terms of carcinogenicity and mutagenicity. The system of determination of the dioxin toxic equivalency factor doesn’t account for it. Thus, during determination of danger of xenobiotics in living organisms we should move away from the determination of acute toxicity and focus on the processes that are started by enzyme systems when a toxicant gets into cells of living organisms.
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Ma, Victor W. S., Yuen Ping Leung, Roger K. C. Ngan, Dora L. W. Kwong, Loretta Tse, Stephen C. K. Law, and Timothy T. C. Yip. "Abstract 4121: Immunohistochemical characterization of xenobiotic detoxification enzymes in normal mucosal epithelium, benign tumors and carcinomas of the nasal and nasopharyngeal regions." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-4121.

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Ma, Victor Wan-San, Goretti Hoi-Yan Cheung, Eunice Yuen-Ting Lau, and William Chi-Shing Cho. "Abstract 3597: Xenobiotic detoxification enzymes and cancer risk: A multiplex immunofluorescence detection of AE1/AE3, GSTA1 and GSTA3 in the tissue microarrays of gastrointestinal tract." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-3597.

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Dietz, Birgit, Ghenet Hagos, Jian Guo, Matthew Main, Daniel Lantvit, Norman Farnsworth, Guido Pauli, Richard van Breemen, and Judy Bolton. "Abstract A43: Hops (humulus lupulus) induce detoxification enzymesin vivo." In Abstracts: Frontiers in Cancer Prevention Research 2008. American Association for Cancer Research, 2008. http://dx.doi.org/10.1158/1940-6207.prev-08-a43.

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Frančič, Nina, Polonca Nedeljko, and Aleksandra Lobnik. "Mesoporous silica as the enzyme carrier for organophosphate detection and/or detoxification." In SPIE Optics + Optoelectronics, edited by Francesco Baldini, Jiri Homola, and Robert A. Lieberman. SPIE, 2013. http://dx.doi.org/10.1117/12.2019057.

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Itokawa, Kentaro. "Targeting a detoxification enzyme gene using two genome editing technologies to test causality for insecticide resistance." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.114027.

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Sehlstedt, Maria, Anders Blomberg, Annelie Behndig, Ian Mudway, Thomas Sandström, and Jamshid Pourazar. "Diesel Exhaust Exposure Increases Nuclear Translocation Of AhR And Suppresses The Detoxification Enzyme NQO1 In Human Airways." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1027.

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Reports on the topic "Detoxification enzymes"

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Rajan, K. S. Enzymatic Detoxification of Chemical Warfare Agents: Immobilization of the Enzyme for Material Surfaces. Fort Belvoir, VA: Defense Technical Information Center, January 1991. http://dx.doi.org/10.21236/ada231056.

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Tiedje, J. M. Complete Detoxification of Short Chain Chlorinated Aliphatic Compounds: Isolation of Halorespiring Organisms and Biochemical Studies of the Dehalogenating Enzyme Systems - Final Report. Office of Scientific and Technical Information (OSTI), October 1999. http://dx.doi.org/10.2172/775427.

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Loeffler, F. E., and J. M. Tiedje. Complete detoxification of short chain chlorinated aliphatics: Isolation of halorespiring organisms and biochemical studies of the dehalogenating enzyme systems. 1997 annual progress report. Office of Scientific and Technical Information (OSTI), January 1997. http://dx.doi.org/10.2172/13697.

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Tiedje, J. M. Complete detoxification of short chain chlorinated aliphatic compounds: Isolation of halorespiring organisms and biochemical studies of the dehalogenating enzyme systems. 1998 annual progress report. Office of Scientific and Technical Information (OSTI), June 1998. http://dx.doi.org/10.2172/13698.

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