Academic literature on the topic 'Design per componenti'

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Design per componenti.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Design per componenti"

1

McCullagh, P. J. J. "Biomechanics and Design of Shoulder Arthroplasty." Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 209, no. 4 (December 1995): 207–13. http://dx.doi.org/10.1243/pime_proc_1995_209_347_02.

Full text
Abstract:
Since the introduction by Neer in 1973 of the metal-on-plastic unconstrained total shoulder replacement, unfortunately there have been no long-term clinical follow-up reports. Short- to mid-term information (less than ten years) indicates good to excellent clinical results in approximately 90 per cent of cases. While this early experience is encouraging, much attention has been focused on tucencies of the glenoid componenti which although they may not predispose to failure, have led to considerable design activity. The humeral component has also advanced in design, with modularity of the head in particular providing greater intra-operative flexibility. State-of-the-art instrumentation, borrowing key features found beneficial to hip and knee joint replacement, is an important advancement in contemporary systems. The aim of this paper is to position shoulder arthroplasty in relation to biomechanical considerations and recommendations from clinical experience.
APA, Harvard, Vancouver, ISO, and other styles
2

Mackie, Gillian. "Abstract and vegetal design in the San Zeno chapel, Rome: the ornamental setting of an early medieval funerary programme." Papers of the British School at Rome 63 (November 1995): 159–82. http://dx.doi.org/10.1017/s0068246200010229.

Full text
Abstract:
DECORAZIONE ASTRATTA E FLOREALE NELLA CAPPELLA DI SAN ZENO, ROMA: PREPARAZIONE ORNAMENTALE DI UN PROGRAMMA FUNERARIO ALTO MEDIEVALELa cappella di San Zeno è notevole, non soltanto per il suo coerente programma iconografico, ma per le decorazioni astratte e floreali che la abbelliscono. Queste includono volute animate, decorazioni tessili, scuri a due teste, fiori, scudi, elaborati contorni multipli e ghirlande floreali. Tutto ciò è analizzato in questo studio, alla ricerca della loro possibile fonte e del loro significato simbolico. Uno degli scopi principali era scoprire se le fonti degli ornamenti fossero identiche a quelle del programma figurale, ovvero se, essendo indipendenti dalle figure, potessero essere associate ad esercizi di laboratorio.Sembrerebbe che alcune delle decorazioni provenissero da Ravenna tramite un libro di motivi, ora perduto insieme alle decorazioni monumentali originali. Altri motivi, invece, sebbene si riferiscano in termini generali a forme decorative passate, usano come modelli per i dettagli i materiali raggruppati a Santa Prassede da Papa Pasquale I; questi erano disegnati sulla base di sculture medievali e classiche tuttora esistenti a Santa Prassede. Viene anche suggerito che i tessuti che Pasquale donò alla Chiesa potrebbero essere stati copiati dai mosaicisti.Un significato simbolico è stato trovato in molte componenti dell'ornamento. Ad esempio, lo strano nome medievale della Cappella di Zeno, Hortus Paradisi, può essere soddisfacentemente spiegato dalla lussureggiante componente floreale dei muri superiori, che rappresenta in termini simbolici il Paradiso.
APA, Harvard, Vancouver, ISO, and other styles
3

Bonfanti, Angelo, Federico Brunetti, and Elisa Pisani. "Il valore dello store design nel settore grocery: le scelte differenzianti della catena distributiva Mpreis." MERCATI & COMPETITIVITÀ, no. 3 (October 2012): 33–55. http://dx.doi.org/10.3280/mc2012-003003.

Full text
Abstract:
I punti vendita del moderno grocery sono generalmente realizzati in base a logiche di funzionalitÀ ed efficienza, piů che di stupore e coinvolgimento sensoriale ed emotivo dei clienti. Anche in letteratura, la maggiore attenzione dal punto di vista dello store design č dedicata all'analisi dei contesti non grocery. Questo lavoro si propone di presentare la singolare esperienza di MPreis, catena di supermercati austriaca, che si caratterizza per valorizzare i diversi elementi di store design, tra cui in particolare l'architettura, al fine di creare identitÀ e differenziazione competitiva nei territori in cui opera. Sulla base dell'approccio di ricerca qualitativo del case study, l'analisi dei dati raccolti evidenzia il coraggio della diversitÀ, l'impegno nella ricerca estetica e il senso del dono come elementi centrali delle condotte dell'azienda oggetto di studio. Il paper consente cosě, da un lato, di includere lo store design tra le leve competitive a disposizione del retail grocery e, dall'altro, di far emergere il senso del dono e il possesso di un adeguato company ethos come componenti tra i piů imprescindibili per l'impresa del futuro.
APA, Harvard, Vancouver, ISO, and other styles
4

Napoli, Federico. "Las componentes ambientales en el diseño urbano: Lima - Perú." Campus 27, no. 33 (June 27, 2022): 105–20. http://dx.doi.org/10.24265/campus.2022.v27n33.07.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Jensen, N. C., and I. Hvid. "Load Bearing Capacity in Total Ankle Joint Replacement." Engineering in Medicine 15, no. 3 (July 1986): 149–51. http://dx.doi.org/10.1243/emed_jour_1986_015_038_02.

Full text
Abstract:
The influence of some simple design variations on the compressive load bearing capacity of tibial and talar prosthetic components in total ankle joint replacement were investigated in an attempt to suggest improvements to current prosthetic designs. Eighteen paired ankle joint preparations were fitted with three types of tibial components and two types of talar components. The tibial component with an intramedullary peg tolerated significantly higher loads before mechanical failure than the two other designs that were equal in load bearing capacity. The mean value of ultimate force was 40 per cent higher and the mean value of yield force was 15 per cent higher. However, for the coefficient of stiffness there was a significant fall of 18 per cent in the mean value. The talar components were equal in load bearing capacity and stiffness.
APA, Harvard, Vancouver, ISO, and other styles
6

Gallo, Anna, and Sergio Leon Guerrero. "Juan María Montijano." Revista Eviterna, no. 10 (September 28, 2021): 55–66. http://dx.doi.org/10.24310/eviternare.vi10.12956.

Full text
Abstract:
A partire da una riflessione maturata da Juan María Montijano riguardo la natura metafisica del design, intesa quale custode del reale significato degli oggetti che ci circondano, lo studio approfondisce il ‘valore immateriale dei prodotti materiali' con l’intento di invitare a porre attenzione non solo sul binomio forma-funzione ma anche sulla stratificazione intangibile che lo sostiene. Una dimensione considerata privilegiata in quanto qui si incontrano il processo progettuale e l’esperienza d’uso contribuendo entrambi a liberare gli oggetti dall’anonimato della standardizzazione e dai rischi della spersonalizzazione, dotandoli di una sorta di ‘biografia’. In questo modo le cose si trasformano in storie, linguaggi, relazioni. A supporto della tesi della ‘metafisica del disegno’, il terzo paragrafo indaga il pensiero di studiosi del Novecento – da Barthes, Baudrillard, Selle, Kopytoff, De Fusco, le cui ricerche convergono da prospettive differenti verso l’idea di una dimensione culturale del quotidiano costruita mediante i significati e i segni appartenenti alle sue componenti piccole e grandi. In tal senso anche il termine ‘patrimonio’ viene considerato nell’accezione inglese di Cultural Heritage, ovvero come giacimento attivo da continuare ad alimentare nel tempo attraverso strumenti in grado di valorizzarne i contenuti aggiornandoli e rendendoli accessibili e fruibili. Tra questi la tecnica dello storytelling, canale narrativo che pone in evidenza in particolar modo l’immateriale, ritrovando quindi nei contenitori culturali come archivi e biblioteche delle dimensioni in grado di favorire lo sviluppo di azioni strategiche finalizzate a incrementare conoscenza e cultura. Da qui la parte finale del testo è dedicata ad esaminare l’opera di valorizzazione portata avanti da Juan María Montijano per oltre quindici anni nella Biblioteca e nell’Archivio del san Carlo alle Quattro Fontane a Roma al fine di tutelare, raccontare e trasmettere nel tempo la memoria storica custodita al suo interno.
APA, Harvard, Vancouver, ISO, and other styles
7

Aprianto, Anggi, Fahmi Rizal, Remon Lapisa, Ambiyar ., Wakhinuddin Wakhid, Sukardi ., and Afif Rahman Riyanda. "Curriculum Evaluation of Light Vehicle Engineering Department with Discrepancy Model as Per Industry Needs." Journal of Education Research and Evaluation 4, no. 4 (November 10, 2020): 387. http://dx.doi.org/10.23887/jere.v4i4.28978.

Full text
Abstract:
The implementation of the curriculum as per industrial needs should be improved in terms of qualifications of teachers, tools, practicum materials, and the use of learning models as per industry needs. This study aims to evaluate the used curriculum of light vehicle engineering department as per industry needs. This study uses discrepancy evaluation model (design, installation, process, product and comparison) that describes the implementation of curriculum according to the industry needs from various aspects, namely: design, installation, process, product and comparison. The study results concluded that achievement level of curriculum implementation as needed in the design component obtained an average score of 4.28 (83.17%) classed in a good category; installation components get an average score of 3,502 (78.47%) classified in sufficient categories; process components get an average score of 4.05 (81.75%) classed in a good category; and product components that scored an average of 4.02 (81.26%) classified in a good category. As well as in the comparison component that obtained an average score of 3,324 (74.27%) classified in sufficient categories. The implementation of vocational school curriculum majoring in light vehicle engineering as a whole is categorized as sufficient. Therefore, it needs a follow-up from the relevant parties for a better implementation.; one of which is by revising the curriculum to fit the needs of the industry.
APA, Harvard, Vancouver, ISO, and other styles
8

Bottero, Marta, Caterina Caprioli, Giulia Datola, Alessandra Oppio, and Francesca Torrieri. "Regeneration of Rogoredo railway: a combined approach using multi-criteria and financial analysis [Un approccio integrato per la rigenerazione dello scalo ferroviario di Rogoredo]." Valori e Valutazioni 31 (February 2023): 89–102. http://dx.doi.org/10.48264/vvsiev-20223107.

Full text
Abstract:
Abandoned areas such as neglected railways and urban voids represent a suitable opportunity for the regeneration and requalification of cities, according to the paradigms of sustainability and resilience. Urban transformation and urban regeneration processes are characterized by a high level of complexity, a dynamic behavior over time and interactions between the various actors involved in the process. Within this context, the present paper proposes the application of a combined evaluation framework, based on the integration of Multi-Criteria Decision Analysis (MCDA) with a Financial Analysis (FA) to assess different strategic scenarios for the regeneration of the Rogoredo railways area (Milan, Italy). The purpose of this framework is to take into account the complexity of the decision- making process, considering both the qualitative (social and environmental) and quantitative (economic- financial) aspects. In detail, the railway yards in the Rogoredo area in Milan (Italy) represent an emblematic case. The city of Milan, within the Territory Governance Plan (PGT), has already proposed interventions in this site aimed at reconnecting the infrastructural node and making it an attractive and inclusive pole. The present paper demonstrates the usefulness of evaluation procedures in supporting the entire decision-making process and defining the most suitable scenario considering the initial objective and the stakeholders’ interests. The innovative value provided by this application is represented precisely by the possibility of considering both the developer point of view through FA and the broader public perspective through the support of MCDA. This approach allowed to build and evaluate transformation scenarios capable of both attracting potential investors and promoting sustainable mobility models, social inclusion, eco-sustainable development, improvement of environmental quality through the design of new public areas, green spaces, and services for citizens. I vuoti urbani, quali ex aree industriali ed ex scali ferro- viari, rappresentano oggi un’importante occasione di riconversione delle città, nell’ottica di uno sviluppo in chiave sostenibile, resiliente e circolare. Tuttavia, gli interventi di trasformazione e rigenerazione urbana sono caratterizzati da un elevato grado di complessità e dinamicità, così come da un’elevata interazione tra le diverse componenti urbane, quali gli aspetti economici, ambientali, sociali e tra i diversi attori coinvolti nel processo. In questo contesto, l’approccio metodologico proposto nel presente contributo combina le Analisi- Multicriteri (AMC) con l’analisi Analisi Finanziaria (AF). Questo modello permette di analizzare e supportare il processo decisionale nella sua complessità, considerando sia gli aspetti qualitativi (sociali e ambientali) sia quelli quantitativi (economico- finanziari). Il caso degli scali ferroviari dell’area di Rogoredo a Milano (Italia) rap- presenta un caso emblematico. La stessa città di Milano, già all’interno del Piano di Governo del Territorio (PGT), propone interventi volti alla riconnessione di questo nodo infrastrutturale per renderlo un polo attrattivo e inclusivo. L’obiettivo di questo contributo è quello di applicare le AMC con l’AF per la valutazione di scenari alternativi, volti alla riqualificazione dell’ex scalo ferroviario di Rogoredo. La valutazione diventa, quindi, parte integrante dell’intero processo decisionale, supportandone tutte le fasi, da quella iniziale fino alla definizione dello scenario più idoneo agli obiettivi prefissati e agli interessi degli stakeholder coinvolti. Il valore aggiunto fornito dalla presente applicazione è rappresentato proprio dalla possibilità di considerare sia il punto di vista degli investitori, attraverso l’AF, sia la più ampia prospettiva pubblica, attraverso il supporto delle AMC. In questo modo è stato possibile costruire e valutare scenari di trasformazione in grado di attrarre possibili investitori e al tempo stesso capaci di promuovere modelli di mobilita sostenibile, forme di inclusione sociale, sviluppo eco-sostenibile, miglioramento della qualità ambientale, attraverso la progettazione di nuove aree pubbliche, spazi verdi e servizi per i cittadini. In questo processo, la valutazione assume un ruolo essenziale in quanto consente di mettere in luce i diversi obiettivi perseguiti dall’intervento di rigenerazione e le loro eventuali conflittualità. Inoltre, la loro identificazione può supportare la definizione di scenari alternativi di sviluppo, rendendo partecipati sia il processo progettuale sia quello decisionale.
APA, Harvard, Vancouver, ISO, and other styles
9

Krammer, Oliver, Péter Martinek, Balazs Illes, and László Jakab. "Machine learning-based prediction of component self-alignment in vapour phase and infrared soldering." Soldering & Surface Mount Technology 31, no. 3 (June 3, 2019): 163–68. http://dx.doi.org/10.1108/ssmt-11-2018-0045.

Full text
Abstract:
Purpose This paper aims to investigate the self-alignment of 0603 size (1.5 × 0.75 mm) chip resistors, which were soldered by infrared or vapour phase soldering. The results were used for establishing an artificial neural network for predicting the component movement during the soldering. Design/methodology/approach The components were soldered onto an FR4 testboard, which was designed to facilitate the measuring of the position of the components both prior to and after the soldering. A semi-automatic placement machine misplaced the components intentionally, and the self-alignment ability was determined for soldering techniques of both infrared and vapour phase soldering. An artificial neural network-based prediction method was established, which is able to predict the position of chip resistors after soldering as a function of component misplacement prior to soldering. Findings The results showed that the component can self-align from farer distances by using vapour phase method, even from relative misplacement of 50 per cent parallel to the shorter side of the component. Components can self-align from a relative misplacement only of 30 per cent by using infrared soldering method. The established artificial neural network can predict the component self-alignment with an approximately 10-20 per cent mean absolute error. Originality/value It was proven that the vapour phase soldering method is more stable from the component’s self-alignment point of view. Furthermore, machine learning-based predictors can be applied in the field of reflow soldering technology, and artificial neural networks can predict the component self-alignment with an appropriately low error.
APA, Harvard, Vancouver, ISO, and other styles
10

Bleidorn, Wiebke, Anke Hufer, Christian Kandler, Christopher J. Hopwood, and Rainer Riemann. "A Nuclear Twin Family Study of Self–Esteem." European Journal of Personality 32, no. 3 (May 2018): 221–32. http://dx.doi.org/10.1002/per.2136.

Full text
Abstract:
Twin studies suggest that both genes and environments influence the emergence and development of individual differences in self–esteem. However, different lines of research have emphasized either the role of genes or of environmental influences in shaping self–esteem, and the pathways through which genes and environments exert their influence on self–esteem remain largely unclear. In this study, we used nationally representative data from over 2000 German twin families and a nuclear twin family design (NTFD) to further our understanding of the genetic and environmental influences on individual differences in self–esteem. Compared with classical twin designs, NTFDs allow for finer–grained descriptions of the genetic and environmental influences on phenotypic variation, produce less biased estimates of those effects, and provide more information about different environmental influences and gene–environment correlation that contribute to siblings’ similarity. Our NTFD results suggested that additive and non–additive genetic influences contributed to individual differences in self–esteem as well as environmental influences that are both shared and not shared by twins. The shared environmental component mostly reflected non–parental influences. These findings highlight the increased sensitivity afforded by NTFDs but also remaining limitations that need to be addressed by future behavioural genetic work on the sources of self–esteem. Copyright © 2018 European Association of Personality Psychology
APA, Harvard, Vancouver, ISO, and other styles

Dissertations / Theses on the topic "Design per componenti"

1

Di, Renzo Antonio. "Sviluppo di metodologie per la qualifica di componenti mediante termoelasticità." Doctoral thesis, Università degli studi di Padova, 2007. http://hdl.handle.net/11577/3425002.

Full text
Abstract:
The main subject of the thesis is the development of several methodologies aimed to qualify mechanical components through thermoelasticity. Such essay begins with the analysis of the thermoelastic method of measure. We come to develop a new measure methodology of stress maps on mechanical rotation components through two test cases; they show their application to the stress analysis on the joint of water meter and fan cooling.
APA, Harvard, Vancouver, ISO, and other styles
2

Golini, Vittorio. "Continuous innovation in food and beverage packaging design. Progetto di tutorial per lo studio di nuove forme di contenitore in PET." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2016.

Find full text
Abstract:
Mi sono occupato di confezionamento di bevande, un settore che utilizza largamente il PET. Il progetto di tesi consiste in un processo che serve a ideare nuove forme di contenitore in PET attraverso strumenti di ricerca e innovazione.
APA, Harvard, Vancouver, ISO, and other styles
3

Ratti, Marco. "Design, ottimizzazione e produzione di un componente aerodinamico ad effetto suolo per vettura monoposto a ruote scoperte." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amslaurea.unibo.it/22818/.

Full text
Abstract:
L’obiettivo di questa tesi è fornire un approccio metodologico al design, all’ottimizzazione aerodinamica e strutturale, alla simulazione e alla produzione di un componente aerodinamico ad effetto suolo per monoposto a ruote scoperte. In particolare, si tratterà approfonditamente un condotto di Venturi posizionato al lato della monoscocca di un veicolo di Formula SAE (Society of Automotive Engineers) di UniBo Motorsport, il team di corse dell’Università di Bologna. Si procederà ad un’analisi preliminare delle caratteristiche aerodinamiche di una vettura di Formula SAE, evidenziando le principali filosofie di sviluppo e il funzionamento dei vari organi che compongono il pacchetto aerodinamico. Successivamente, si analizzerà approfonditamente l’aspetto di simulazione aerodinamica bidimensionale e tridimensionale, necessario per definire la forma di un condotto di Venturi e delle superfici aerodinamiche annesse. In seguito, si procederà con un approfondimento sull’uso della metodologia agli elementi finiti (FEM) per l’analisi strutturale di un componente in materiale composito applicata al Venturi in questione. Infine, si affronterà l’aspetto produttivo e di realizzazione del componente.
APA, Harvard, Vancouver, ISO, and other styles
4

Semeraro, Matteo Ignazio. "Angular, React, Vue.js: confronto tra le principali soluzioni per lo sviluppo front-end." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/17299/.

Full text
Abstract:
Scopo di questa dissertazione è analizzare l’evoluzione dello sviluppo front-end di applicazioni web, come cambiamenti ha subito nel tempo, quali problemi sono sorti e con quali tecnologie questi siano stati risolti. Fornirò una panoramica esaminando i concetti moderni di sviluppo, ovvero i components, i design pattern MVC, MVVM e FLUX e i linguaggi di scripting. Per farlo, analizzerò la storia, i core concept e i pattern adottati da tre fondamentali framework affermati nel mondo dello sviluppo web: Angular, React e Vue.js. Infine effettuerò un confronto utilizzando dati statistici raccolti dai principali siti di riferimento del mondo dell’informatica quali Github e Stackoverflow, mettendo a confronto le caratteristiche principali dei framework e come queste influiscono sulla learning curve e sull’human recruiting. Con questi dati, trarrò delle conclusioni personali riguardo la scelta di una determinata tecnologia per lo sviluppo di una SPA, Single Page App.
APA, Harvard, Vancouver, ISO, and other styles
5

La, Mattina Alessandro. "Progettazione di un componente software PLC di una macchina automatica per la lavorazione del legno con approccio Model-Based Design." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019.

Find full text
Abstract:
La tesi consiste nell’applicazione del Model-Based Design alla progettazione di un software volto al controllo di una macchina automatica per la lavorazione del legno. Gli obbiettivi di questo lavoro sono: - progettare attraverso uno standard: si vuole verificare l’efficacia di un metodo di progettazione con delle fasi ben definite; - concentrare il più possibile la progettazione del software sul modello: si vuole progettare la logica di controllo interamente per via grafica e lasciare a un software il compito di tradurre i diagrammi in codice; - diminuire il tempo di test in macchina: si vuole ridurre il tempo di test del software di controllo in macchina grazie a una verifica efficace del codice in ambiente simulato. L’oggetto che si è scelto di modellare è un dispositivo binario con doppia retroazione: esso descrive il comportamento di molti aspetti della macchina ma in particolare si è scelto di concentrarsi sull’attuatore di una pneumatica bistabile con sensori di attivo e disattivo. I tool utilizzati nella progettazione sono Mechatronic UML e TITAN. Si è fatto estensivo uso del linguaggio Statechart di David Harel e della semantica di modellazione di MechatronicUML. Le fasi del Model-Based Design sono: analisi dei requisiti del prodotto, stesura degli scenari di utilizzo, stesura del modello, generazione del codice a partire dal modello, test del codice generato in ambiente simulato, adattamento del codice al sistema PLC esistente e implementazione e test in macchina.
APA, Harvard, Vancouver, ISO, and other styles
6

Sartori, Emanuele. "Study, analysis, design and diagnostics of plasma and beam facing components of fusion devices." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3423129.

Full text
Abstract:
Neutral Beam Injection is the horse-power of present and future fusion devices. Modeling plays a fundamental role in anticipating/predicting the performance of the injector and optimizing its behaviour. Successful design can only be achieved through integrated approach between physics and engineering. In the last three years, my research activity has been carried out at Consorzio RFX, where the ultimate neutral beam test facility is being designed and constructed. This PhD thesis has sought to address issues critical for the design and operation of such injectors. As the dynamics of beam acceleration and transport are dominated by the density of the background gas, I developed a reliable code for simulating its distribution in high vacuum systems. The density topic is strictly connected to the characteristics of the gas cell where the beam is neutralised before reaching the fusion plasma. Consequently I developed the final design of the Neutraliser and performed the thermo-mechanical verifications, a critical task because of the high power load interesting the beam facing component. I considered also other issues related to the study of beam components - e.g. the beam source in its operating thermal conditions. The development and application of methods and models, the experimental validation and benchmarking, are described in the perspective of a practical use in neutral beam engineering.
Gli iniettori di neutri sono e saranno il principale sistema di riscaldamento nelle macchine da fusione. La modellazione numerica gioca un ruolo fondamentale nel predirne le prestazioni ed ottimizare il suo funzionamento, ed un buon design nella fisica e ingegneria può essere raggiunto solo tramite un apporoccio integrato tra i due. Nei tre anni trascorsi, ho svolto la mia attività di ricerca presso il Consorzio RFX, dovesarà installato e testato il più grande iniettore di neutri al mondo, ed il suo design è in corso. Questa tesi di dottorato ha affrontato aspetti critici per il design e le operazioni di questa tipologia di iniettori. Poiché le dinamiche di accelerazione e trasporto del fascio di particelle sono dominate dalla presenza di gas residuo, ho sviluppato un codice robusto ed affidabile per simulare la sua distribuzione e flusso nei sistemi di alto vuoto; questo argomento è strettamente legato alle caratteristiche ed il design della cella di gas dove il fascio deve venire neutralizzato prima di raggiungere il plasma da fusione, di cui ho sviluppato il final design ed ho eseguito le verifiche termomeccaniche, che presentano tutte le difficoltà di componenti affacciati ad un fascio di particelle ad alta energia. Altri aspetti hanno riguardato lo studio di componenti e diagnostiche del fascio. Vengono trattati lo sviluppo e l’applicazione di metodi e modelli, e la loro eventuale validazione sperimentale; i risultati sono valutati nella prospettiva di un uso pratico nella ingegneria degli iniettori di neutri.
APA, Harvard, Vancouver, ISO, and other styles
7

Nouri, Ayoub. "Rigorous System-level Modeling and Performance Evaluation for Embedded System Design." Thesis, Université Grenoble Alpes (ComUE), 2015. http://www.theses.fr/2015GRENM008/document.

Full text
Abstract:
Les systèmes embarqués ont évolué d'une manière spectaculaire et sont devenus partie intégrante de notre quotidien. En réponse aux exigences grandissantes en termes de nombre de fonctionnalités et donc de flexibilité, les parties logicielles de ces systèmes se sont vues attribuer une place importante malgré leur manque d'efficacité, en comparaison aux solutions matérielles. Par ailleurs, vu la prolifération des systèmes nomades et à ressources limités, tenir compte de la performance est devenu indispensable pour bien les concevoir. Dans cette thèse, nous proposons une démarche rigoureuse et intégrée pour la modélisation et l'évaluation de performance tôt dans le processus de conception. Cette méthode permet de construire des modèles, au niveau système, conformes aux spécifications fonctionnelles, et intégrant les contraintes non-fonctionnelles de l'environnement d'exécution. D'autre part, elle permet d'analyser quantitativement la performance de façon rapide et précise. Cette méthode est guidée par les modèles et se base sur le formalisme $mathcal{S}$BIP que nous proposons pour la modélisation stochastique selon une approche formelle et par composants. Pour construire des modèles conformes au niveau système, nous partons de modèles purement fonctionnels utilisés pour générer automatiquement une implémentation distribuée, étant donnée une architecture matérielle cible et un schéma de répartition. Dans le but d'obtenir une description fidèle de la performance, nous avons conçu une technique d'inférence statistique qui produit une caractérisation probabiliste. Cette dernière est utilisée pour calibrer le modèle fonctionnel de départ. Afin d'évaluer la performance de ce modèle, nous nous basons sur du model checking statistique que nous améliorons à l'aide d'une technique d'abstraction. Nous avons développé un flot de conception qui automatise la majorité des phases décrites ci-dessus. Ce flot a été appliqué à différentes études de cas, notamment à une application de reconnaissance d'image déployée sur la plateforme multi-cœurs STHORM
In the present work, we tackle the problem of modeling and evaluating performance in the context of embedded systems design. These have become essential for modern societies and experienced important evolution. Due to the growing demand on functionality and programmability, software solutions have gained in importance, although known to be less efficient than dedicated hardware. Consequently, considering performance has become a must, especially with the generalization of resource-constrained devices. We present a rigorous and integrated approach for system-level performance modeling and analysis. The proposed method enables faithful high-level modeling, encompassing both functional and performance aspects, and allows for rapid and accurate quantitative performance evaluation. The approach is model-based and relies on the $mathcal{S}$BIP formalism for stochastic component-based modeling and formal verification. We use statistical model checking for analyzing performance requirements and introduce a stochastic abstraction technique to enhance its scalability. Faithful high-level models are built by calibrating functional models with low-level performance information using automatic code generation and statistical inference. We provide a tool-flow that automates most of the steps of the proposed approach and illustrate its use on a real-life case study for image processing. We consider the design and mapping of a parallel version of the HMAX models algorithm for object recognition on the STHORM many-cores platform. We explored timing aspects and the obtained results show not only the usability of the approach but also its pertinence for taking well-founded decisions in the context of system-level design
APA, Harvard, Vancouver, ISO, and other styles
8

Kim, Bunthern. "Contribution to the design and control of a hybrid renewable energy generation system based on reuse of electrical and electronics components for rural electrification in developing countries." Thesis, Toulouse, INPT, 2019. http://www.theses.fr/2019INPT0041/document.

Full text
Abstract:
Bien que le gouvernement cambodgien s’efforce d’augmenter sa production d’électricité pour répondre à sa demande en énergie, il reste toujours dépendant de réseau électrique existant ou de l’extension du réseau dont le coût d’investissement initial est élevé. La solution temporelle consiste à employer un système de production d'énergie distribué qui présente un coût de cycle de vie inférieur et introduit une diversité de technologies pour répondre aux applications. Minimiser les impacts environnementaux représente un objectif majeur du développement durable, compte tenu de l'épuisement des ressources et des capacités d'adaptation limitées de l'environnement. Les ressources en énergies renouvelables ont été bien comprises comme les solutions pour alimenter le développement rural et réduire les impacts environnementaux de la production d’énergie. Suivant les progrès technologiques et de la demande croissante des consommateurs, de grande quantité de déchets électriques et électroniques ont entraîné de graves conséquences pour l’environnement. Les stratégies actuelles reposent principalement sur les techniques classiques de collecte et de traitement des déchets. Ce travail de thèse proposait une solution de réutilisation des composants électroniques dans un système d'énergie renouvelable hybride isolé pour la solution d'électrification pour la zone rurale. Une configuration choisie pour le système proposé est un système de génération hybride solaire-hydroélectrique, car les ressources solaires et hydrauliques sont abondantes dans les zones rurales du Cambodge. Les composants qui sont réutilisés dans la solution comprennent des blocs d’alimentation d’un PC (PSU) pour la partie solaire, des alimentations sans interruption (UPS) et des machines asynchrone triphasées pour la partie hydraulique. Les batteries automobiles usagées sont utilisées pour le stockage d’énergie. Ce travail de thèse aborde dans une première partie l’évaluation des impacts environnementaux de la solution de réutilisation proposée. Cette étude repose sur la méthodologie de l’Analyse du Cycle de Vie (ACV) qui compare les impacts du cycle de vie de la solution proposée à ceux d’une solution conventionnelle. La deuxième partie de ce travail traite des aspects technologiques de la solution de réutilisation, à la fois en théorie et en expérimentation. La première partie de cet aspect concerne la reconversion des blocs d’alimentations usagées. Le bloc d'alimentation, qui contient généralement l'un des quelques types de convertisseurs DC-DC isolés, est réutilisé comme contrôleur de charge, qui est le composant principal du système de générateur photovoltaïque. La dernière partie de cette thèse décrit une nouvelle configuration de générateur basé sur des moteurs asynchrone triphasés. Le générateur monophasé proposé basé sur une machine triphasée est une version modifiée d'une topologie à base de l’onduleur où deux enroulements sont alimentés séparément par sources d'excitation, et l'autre enroulement est connecté à la charge. Une nouvelle modélisation est proposée. Les résultats de simulation sont comparés aux résultats expérimentaux en alimentation sinus. La comparaison met en évidence une supériorité de la nouvelle configuration par rapport à l'ancienne en termes de rendement et de minimisation de pulsations de couple
While the Cambodia’s government is making effort to increase electricity production for its energy demand, it still remains dependent on the existing or the expansion of the centralized grid lines which have high initial investment cost. The temporally solution is to employ a distributed energy generation system which has lower life cycle cost and provides a diversity of technologies to meet the desired applications. Minimizing environmental impacts represents a major objective of sustainable development considering resources depletion and the limited capabilities of the environment to adapt. The potential of renewable energy resources has been well understood as the solutions to power rural development and to reduce the environmental impacts of energy generation. Due to advance in technologies and increasing consumer demands, there has been a vast amount of electrical and electronic waste which introduces severe impacts on the environment. The current strategies mainly rely on conventional waste collection and processing techniques for material recovery. This thesis proposed a solution of reusing discarded components in an isolated hybrid renewable energy system as the solution for electrification of rural Cambodia. This is frugal innovation, local solution with local materials for and with local people. A suitable configuration for the proposed system is a solar-hydro hybrid generation system since solar and water resources are plentiful in rural Cambodia. The components that are reused in the solution after being discarded include computer power supply units (PSUs) for the solar part, uninterruptable power supply units (UPSs) and three phase induction machines for the electrohydro part. Used auto-mobile batteries will be used for the system storage. The thesis presents in the first part the evaluation of the environmental impacts of the proposed reuse solution for rural electrification. The study of the environmental impacts is based on Life Cycle Assessment (LCA) methodology which compares the life cycle impacts of the proposed solution to that of a conventional solution. Moreover, a sensitivity analysis is achieved in order to evaluate the impacts of uncertainties of the environmental impacts. The second part of this work deals with the technological aspects of the reuse solution in both theory and experimentation. The first part of this aspect is focused on the repurposing of used computer power supply units (PSUs), through limited modifications of the circuits in order to increase its range of operation. The PSU which usually contains one of a few types of isolated DC-DC converters is repurposed as charge controller with MPPT control in a cheap micro-controller with very good results. The last part of this thesis studies a new configuration of generators based on re-used three-phase induction motors. The proposed single-phase generator is based on a three-phase machine in a modified version of the coupling and with a rather uncommon supply. Modelling is highly investigated. An inverterassisted topology where two windings will be supplied separately by two inverters for excitation and the remaining winding is connected to load. A new modeling of the generator has been studied. The results of simulation were compared to experimental test results in open loop study. These results have demonstrated the advantages of the new configuration in comparison to the previously proposed inverter-assisted topology in term of efficiency and minimization of torqueripple
APA, Harvard, Vancouver, ISO, and other styles
9

Souza, AlethÃia CarÃzia Baracho de Lima. "Estudos sobre as interaÃÃes das proteÃnas seminais com as cÃlulas espermÃticas e componentes dos diluidores usados na criopreservaÃÃo do sÃmen e sobre marcadores moleculares de parÃmetros do sÃmen em animais de produÃÃo." Universidade Federal do CearÃ, 2014. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=12911.

Full text
Abstract:
FundaÃÃo de Amparo à Pesquisa do Estado do CearÃ
A tese à composta por dois capÃtulos. O primeiro capÃtulo inclui o trabalho cujo objetivo foi investigar o potencial uso de pares de transcritos correlativos baseados em microarranjos como marcadores de fertilidade masculina usando a displasia da bainha fibrosa (DFS) como modelo afetado. Atualmente à bastante reconhecido que a tecnologia de microarranjos pode ser limitada pelos custos e que a qualidade dos transcritos permanece relativamente desconhecida. Para responder essas questÃes, nÃs analizamos pares de transcritos estÃveis por qPCR com um processo sistemÃtico de desenho de primers sistemÃtico. Nesse estudo experimental, nÃs utilizamos amostras de homens com fertilidade comprovada e de homens com diagnÃtico de DFS. Nossa abordagem foi baseada nas sequÃncias de primers dos seis genes de interesse, os quais foram desenhados utilizando os programas Oligo7 e Primer3Plus. A especificidade do primer foi inicialmente analisada in silico atravÃs de pesquisas nos bancos de dados ENSEMBL, University of California Santa Cruz (UCSC), e National Center for Biotechnology Information (NCBI) para uso de sequÃncias especÃficas aos genes alvos. A habilidade dos pares de transcritos em classificar as amostras de homens de fertilidade comprovada das amostras de DFS foi avaliada. Nossos resultados mostraram que em conjunÃÃo com a identificaÃÃo de quatro novos pares estÃveis, a comparaÃÃo dos coeficientes de correlaÃÃo dos valores de C(t) dos DSF revelou a interrupÃÃo de quatro pares estÃveis identificados nas amostras de homens normais. Esta seleÃÃo de pares estÃveis resolve a questÃo sobre a DSF. Em conclusÃo, os resultados mostram efetivamente que o desenho de primers e qPCR podem fornecer um ensaio molecular de baixo custo para avaliar a fertilidade masculina. O segundo capÃtulo divide-se em dois estudos e avalia em carneiros os efeitos de uma dieta suplementada com farelo de castanha de caju. No estudo 1, nosso objetivo foi detectar a presenÃa de transcritos para Heat Shock Protein (HSP70), clusterina (CLU), proteÃna semelhante à subunidade alfa do complexo T (TCP1) e proteÃna do complexo T subunidade 8 (CCT8) no espermatozÃide de ovinos, seguindo a mesma metodologia para qPCR utilizada no capitulo 1. As sequÃncias de primers foram desenhadas utilizando os programas Primer3Plus e Oligo Analyzer. Gene para protamina 2 (PRM2) foi usado como controle interno de reaÃÃo. O sÃmen foi coletado de machos pÃberes Morada Nova utlizando eletroejaculador. As amostras selecionadas para extraÃÃo de RNA espermÃtico seguiram as recomendaÃÃes do ColÃgio Brasileiro de ReproduÃÃo Animal quanto aos parÃmetros de motilidade, vigor e concentraÃÃo. Nossos resultados mostraram a presenÃa de mRNA para a HSP70 nos espermatozÃides de ovinos. Maiores estudos sÃo necessÃrios a fim de confirmar ou refutar a presenÃa das chaperonas TCP1 e CCT8 no espermatozÃide ovino. A presenÃa do transcrito da HSP70 no espermatozÃide de ovinos abre perspectivas para estudos futuros sobre os efeitos do mRNA HSP70 no desenvolvimento embrionÃrio, de modo a avaliar se essa expressÃo ocorre de modo espontÃneo, programado e seqÃencial, e se esses mecanismos se refletem na fertilidade e no desenvolvimento embrionÃrio. O segundo estudo tem como principal objetivo avaliar os efeitos de uma dieta contendo farelo de castanha de caju (FCC) na expressÃo de genes relacionados ao metabolismo dos lipÃdios no mÃsculo Longissimus dorsi de carneiros Morada Nova. Vinte carneiros maduros sexualmente foram divididos em dois grupos baseando-se no peso vivo. Os animais foram mantidos em baias individuais. Durante trÃs meses, o grupo castanha (GCA) foi alimentado com raÃÃo contendo FCC, enquanto o grupo controle (GCO) recebeu raÃÃo à base de milho e soja. As duas dietas eram isocalÃricas e isoprotÃicas, adicionadas de suplemento mineral. Os carneiros tambÃm receberam feno de Tifton e Ãgua à vontade. A quantidade de alimento ofertado (raÃÃo e feno) foi ajustada diariamente para sobra de 10%. Sete genes codificantes de proteÃnas envolvidas direta ou indiretamente foram selecionados como alvos, incluindo: GH, ACACA, CAST, CAPN3, LPL, SCD e FASN. Para normalizaÃÃo, foram selecionados cinco genes candidatos: ACTB, GAPDH, RPL4, RPS18 e TBP. Dentre os sete genes alvos selecionados anteriormente, os alvos GH, ACACA e CAST foram removidos. Os dois primeiros foram removidos devido amplificaÃÃo de alinhamento mÃltiplo (baixa especificidade do primers), enquanto CAST apresentou baixa eficiÃncia de amplificaÃÃo. Da lista de gene alvo final, a expressÃo de somente dois genes foi afetada pela dieta, SCD (p<0.01) e FASN (p<0.05), enquanto LPL (p=0,1022) e CAPN3 (p=0,0939) nÃo apresentaram diferenÃa significativa (p<0.05). Os genes SCD e FASN foram reprimidos no GCA comparada ao GCO. Este à o primeiro relato de que uma raÃÃo contendo FCC afetou a expressÃo gÃnica de proteÃnas envolvidas na deposiÃÃo de lipÃdios no mÃsculo em ovinos. Considerando que uma dieta contendo FCC altera a expressÃo de genes lipogÃnicos sem afetar o ganho de peso nem a eficiÃncia reprodutiva de ovinos, faz da castanha de caju uma importante alternativa para o sistema de produÃÃo de ovinos criados em regiÃes tropicais.
This thesis presents two chapters. In the first chapter, its objective was to investigate the potential use of correlative microarray-based transcript pairs as candidate markers for male fertility using dysplasia of the fibrous sheath (DFS) as an affected model. It is widely recognized that microarray technology may be limited by cost and that the quality of the transcript remains relatively unknown. To address these issues, we analyzed the stable transcript pairs by qPCR with a systematic primer design process. On this experimental study, we used men with proven fertility and men with a diagnosis of DFS. Our approach was based on primer sequences for six genes of interest were designed using Oligo7 and Primer3Plus. Primer specificity was initially assessed in silico by searching the ENSEMBL, University of California Santa Cruz, and National Center for Biotechnology Information databases for nontarget complementary sequences throughout the genome. The ability of transcript pairs to classify samples from males of proven fertility away from DFS was assessed. Our results showed that in conjunction with identifying four new stable transcript pairs, comparison of the DFS qPCR C(t) correlation coefficients revealed the disruption of four stable fertile sample transcript pairs. This suite of transcript pairs resolves DFS. In conclusion, the results show that with effectively designed primers, qPCR may provide an affordable molecular assay to assess male fertility status. Second chapter includes two studies regarding evaluations of ram feeded with supplemented diet with cashew nut. On the frist study, our goal was detect transcripts for Heat Shock Protein (HSP70), Clusterin (CLU), Ovis aries T-complex protein 1 alfa subunit-like protein (TCP1) e Ovis aries chaperonin containing TCP1, subunit 8 (theta) (CCT8) on ram sperm by. For primer designing we used published ESTs from NCBI and manually annotated by us using Primer3Plus and OligoAnalizer. PRM2 was used as internal qPCR control. Semen samples from mature Morada Nova ram were collected by eletroejaculator, washed in PBS and prepared for further RNA extraction. Selected samples followed quality recommendatios from ColÃgio Brasileiro de ReproduÃÃo Animal regarding motility, vigor and concentration. Our results showed presence of mRNA HSP70 on ram sperm and they can possible be envolved in early embryo development, oocyte activation and post fertilization events. Further analyses will be necessary to confirm presence of TCP1 and CCT8 on ram sperm. Our findings indicate new perpectives about the effects of these chaperones during embryo development mesuring if its expression reflects male fertility on the early embryo development. On the second study the the main goal is to evaluate the effects of a lipid-enriched diet containing cashew nut brain on the expression of genes related to lipid metabolism in the longissimus dorsi muscle of Morada Nova rams. Twenty sexually mature and reproductively sound rams were divided in two groups based on ram live weight, and each ram was kept on individual pens. During three months, group 1 (G1) rams were fed with a lipid-rich diet, containing cashew nut bran (CNB), while group 2 (G2) was fed with a meal based on corn and soy. Both diets were isocaloric and isoproteic, and had a mineral mix added-in. The rams also were offered Tifton grass hay and had free access to water. The amount of diet offered (ration plus hay) was adjusted everyday to a maximum waste of 10%. Seven genes coding for proteins directly or indirectly involved in lipid metabolism were initially selected as targets, incluiding GH, ACACA, CAST, CAPN3, LPL, SCD, and FASN. Also, five genes were selected as reference genes, ACTB, GAPDH, RPL4, RPS18 and TBP. From the seven genes originally selected as targets, GH, ACACA and CAST were removed, leaving the final list with four targets. The first two genes were removed due to alternative pairing of the primers (low specificity), while CAST showed low amplification efficiency during PCR reaction. From the final target list, the expression of only two genes was affected by diet, SCD (p<0.01) and FASN (p<0.05), while LPL (p=0,1022) and CAPN3 (p=0,0939) were not different at the p<0.05 level. Both SCD and FASN genes were down-regulated in G1 (lipid-rich diet containing CNB) compared to G2. These genes are involved in lipogenic pathways, related to tissue lipid deposition; therefore, these results were expected. This is the first time that a fat-rich diet based on CNB was shown to affect gene expression of proteins involved in fat deposition in carcass muscles of rams. Longissimus dorsi is one of the finest meat cuts. Considering that human diets rich in poli-unsaturated fatty acids (PUFA) can decrease the risk of heart and other chronic diseases, a change in the fatty acid profile of this muscle could contribute to a healthier diet, aggregating value to the end-product of the lamb meat market. The effects of CNB-based diet on the gene expression of SCD and FASN support the notion that such diet, as previously shown for other sources of lipid in ruminants, can potentially change the fatty acid composition of L. dorsi, but this hypothesis needs to be experimentally verified by profiling fatty acids in animals fed CNB versus carbohydrate-based diets. CNB use as an ingredient in animal feeding is environmentally-friendly, since it contributes to by-product recycling from the agroindustrial plants in Northeast Brazil. Also, considering that CNB-based diet changes lipogenic gene expression without affecting weight gain or reproductive status of the rams, as shown in another work from our team, makes CNB a very important alternative food in ram production systems in tropical regions.
APA, Harvard, Vancouver, ISO, and other styles
10

Leserf, Patrick. "Optimisation de l’architecture de systèmes embarqués par une approche basée modèle." Thesis, Toulouse, ISAE, 2017. http://www.theses.fr/2017ESAE0008/document.

Full text
Abstract:
L’analyse de compromis d’un modèle système a pour but de minimiser ou de maximiser différents objectifs tels que le coût ou les performances. Les méthodes actuelles de type OOSEM avec SysML ou ARCADIA sont basées sur la classification ; il s’agit de définir les différentes variantes de l’architecture d’un système de base puis d’analyser ces variantes. Dans ces approches, les choix d’architecture sont contraints : la plateforme d’exécution et la topologie sont déjà figées. Nous proposons la notion de « points de décision » pour modéliser les différents choix du système, en utilisant de nouveaux stéréotypes. L’avantage est d’avoir une modélisation plus « compacte » des différentes variantes et de piloter l’exploration des variantes en utilisant des contraintes. Lorsque le concepteur définit l’architecture du système, des points de décisions sont insérés dans le modèle du système. Ils permettent de modéliser la redondance ou le choix d’une instance pour un composant, les variations des attributs d’un composant, ou l’allocation des activités sur les blocs. Les fonctions objectifs sont définies dans un contexte d’optimisation à l’aide du diagramme paramétrique de SysML. Nous proposons des transformations du modèle SysML vers un problème de satisfaction de contraintes pour l’optimisation (CSMOP) dont la résolution nous permet d’obtenir l’ensemble des architectures optimales. Cette transformation est implantée dans un démonstrateur (plug-in Eclipse) permettant une utilisation conjointe de l’outil Papyrus et de solveurs, disponibles sous forme de logiciels libres. La méthode est illustrée avec des cas d’étude constitués d’une caméra stéréoscopique puis d’un drone, l’ensemble étant modélisé avec Papyrus
Finding the set of optimal architectures is an important challenge for the designer who uses the Model-Based System Engineering (MBSE). Design objectives such as cost, performance are often conflicting. Current methods (OOSEM with SysML or ARCADIA) are focused on the design and the analysis of a particular alternative of the system. In these methods, the topology and the execution platform are frozen before the optimization. To improve the optimization from MBSE, we propose a methodology combining SysML with the concept of “decision point”. An initial SysML model is complemented with “decisions points” to show up the different alternatives for component redundancy, instance selection and allocation. The constraints and objective functions are also added to the initial SysML model, with an optimiza-tion context and parametric diagram. Then a representation of a constraint satisfaction problem for optimization (CSMOP) is generated with an algorithm and solved with an existing solver. A demonstrator implements this transformation in an Eclipse plug-in, combining the Papyrus open-source tool and CSP solvers. Two case studies illustrate the methodology: a stereoscopic camera sensor module and a mission controller for an Unmanned Aerial Vehi-cle (UAV)
APA, Harvard, Vancouver, ISO, and other styles

Books on the topic "Design per componenti"

1

Rovida, Maria Antonietta, ed. Fonti per la storia dell'architettura, della città, del territorio. Florence: Firenze University Press, 2008. http://dx.doi.org/10.36253/978-88-8453-722-5.

Full text
Abstract:
The contributions presented at the study day held in Empoli in May 2006 – now collected in book form – are intended to provide a contribution to the debate on the relations between the teaching of history of architecture, design and historiography. Each essay addresses a specific issue, proposing an analysis and valorisation of the sources (documents, images, diaries etc.) and the resources available for research, representation and design. Taken as a whole, the collective work aims at defining a history of architecture focused on a knowledge and understanding of how, at different times and in different places, man has interacted with the geographical or environmental context to organise the physical space. A history of architecture in seamless relation with that of the city and the territory. A history of architecture that posits itself as an essential component in the design culture of architects and town planners, fostering a mode of intervention generated by a profound knowledge of the complex realities in which it takes shape.
APA, Harvard, Vancouver, ISO, and other styles
2

Donatis, Antonio De. AdvancED ActionScript Components: Mastering the Flash Component Architecture. Apress, 2008.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
3

Donatis, Antonio De. AdvancED ActionScript Components: Mastering the Flash Component Architecture. Springer London, Limited, 2006.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
4

AdvancED ActionScript Components: Mastering the Flash Component Architecture (Advanc). friends of ED, 2006.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
5

Saha, Samar K. Compact Models for Integrated Circuit Design: Conventional Transistors and Beyond. Taylor & Francis Group, 2018.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
6

Saha, Samar K. Compact Models for Integrated Circuit Design: Conventional Transistors and Beyond. Taylor & Francis Group, 2018.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
7

Saha, Samar K. Compact Models for Integrated Circuit Design: Conventional Transistors and Beyond. Taylor & Francis Group, 2017.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
8

Saha, Samar K. Compact Models for Integrated Circuit Design: Conventional Transistors and Beyond. Taylor & Francis Group, 2018.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
9

Saha, Samar K. Compact Models for Integrated Circuit Design: Conventional Transistors and Beyond. Taylor & Francis Group, 2018.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
10

Singh, Rajesh Kumar, ed. Key Heterocyclic Cores for Smart Anticancer Drug–Design Part I. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/97898150400741220101.

Full text
Abstract:
This book provides an update on heterocyclic compounds that serve as key components of anti-cancer agents administered in pre-clinical settings. Many of the compounds highlighted in the book are being actively investigated for the bioactive properties against a range of cancer cell lines. There is potential for heterocyclic compounds to design agents that can target specific molecules to treat different types of cancers. Chapters are contributed by experts in pharmaceutical chemistry and are written to give a general overview of the topic to readers involved in all levels of research and decision-making in pharmaceutical chemistry and anti-cancer drug design. Part 1 of the book set covers these topics: - Heterocyclic anticancer compounds derived from natural sources with their mechanism of action - The role of terpenoids as anticancer compounds: an insight into prevention and treatment - Recent advances in synthesis and anticancer activity of benzothiazole hybrids as anticancer agents - Structure-activity relationship studies of novel hybrid quinoline and quinolone derivatives as anticancer agents - Tetrazoles: structure and activity relationship as anticancer agents - Progress in nitrogen and oxygen-based heterocyclic compounds for their anticancer activity: an update (2017-2020)
APA, Harvard, Vancouver, ISO, and other styles

Book chapters on the topic "Design per componenti"

1

Yusop, Mohd Rafii, Yusuff Oladosu, Abdul Rahim Harun, Asfaliza Ramli, Ghazali Hussin, Mohd Razi Ismail, and Norhani Abdullah. "Application of mutation techniques and genotype × environment interaction for grain yield in ion beam induced mutant rice lines tested in multiple locations in Malaysia." In Mutation breeding, genetic diversity and crop adaptation to climate change, 226–34. Wallingford: CABI, 2021. http://dx.doi.org/10.1079/9781789249095.0023.

Full text
Abstract:
Abstract Genotype evaluation for stability and high yield in rice is an important factor for sustainable rice production and food security. These evaluations are essential, especially when the breeding objective is to release rice with high yields, adaptability and stability for commercial cultivation. To achieve this objective, this study was carried out to select high-yielding rice genotypes induced by ion beam irradiation. Seeds of the rice variety 'MR219' were subjected to different doses of 320 MeV carbon-ion beam irradiation to determine the optimum dose to produce high mutant frequency and spectrum. The optimum dose was 60 Gy. After several cycles of selection and fixation between 2009 and 2014 (M0-M6), six prospective lines with desirable characters were selected at the M6 generation. The selected mutant lines along with other mutant varieties were then tested at five locations in two planting seasons to select high-yielding and stable genotypes. The experiment was conducted in a randomized complete block design with three replications across the locations and seasons. The pooled analysis of variance revealed highly significant differences (p ≤ 0.01, 0.05) among genotypes, among locations and among genotypes by location by season (G×L×S interaction) for the yield traits except for seasons and genotype by season (G×S interaction). Based on univariate and multivariate stability parameters, rice genotypes were classified into three main categories. The first group comprised genotypes with high yield stability along with high yield per hectare. These genotypes include ML4 and ML6 and are widely adapted to diverse environmental conditions. One line exhibited high yield per hectare but low stability; this genotype (ML9) is suitable for specific environments. The last group had low yield per hectare and high stability and included 'MR220', 'Binadhan4' and 'Binadhan7'. This final group is more suitable for breeding specific traits or perhaps has yield component compensation. Hence, rice mutant lines ML4 and ML6 were recommended for commercial cultivation in Malaysia.
APA, Harvard, Vancouver, ISO, and other styles
2

Rigillo, Marina. "Hybridizing Artifice and Nature: Designing New Soils Through the Eco-Systemic Approach." In Regenerative Territories, 281–95. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-78536-9_18.

Full text
Abstract:
AbstractThe chapter outlines the cultural background for applying design strategies consistent with the challenge of circularity. The contribution focuses on ecological thinking as an effective design approach to produce and implement eco-innovative strategies able at facing environmental and societal challenges of our global age. Then the chapter depicts the Repair research experience in promoting a systemic design approach for recycling and reusing C&D waste as new, anthropogenic soils in peri-urban areas. According to the EEA Report n.6/2017, the chapter posits that the major environmental challenges of the present are not about single issues, such as waste reduction or soil-loss, rather they involve systemic change and design processes, linking together economy, social habits and technological responses. Therefore, the transition towards more sustainable urban metabolism deeply depends from creative visions by which breaking the circuit “take-make-dispose” and promote new—and somehow tentative—visions for implementing circularity at local and global scale. Further postulation in the paper is about assuming the concept of Anthropocene as theoretical ground for such eco-innovative design approach. The scientific evidence of living in human-dominated ecosystems makes designers towards a paradigm shift concerning the overcoming of the typical artificial/natural dichotomy by exploring the augmented opportunities in designing sustainable and resilient habitats thanks to a more collaborative, plural and innovative design approach: “What is important and significant here is how ecology and landscape architectural design might invent alternative forms of relationships between people, places and cosmos” (Corner, ‘Ecology and Landscape as agents of Creativity’, 1997, reprint in Reed &Lister (2018), Op. Cit., pp. 40–65, p. 42). Starting from these assumptions, the paper deepens the experience of collaborative design for implementing recycle and reuse of C&D waste for producing new technical soils, according to both the regulatory constraints (and potentials) and the site-specific features. The research goal is to provide new vegetated soils by waste thanks to an innovative design process based on both circular economy principles and collaborative knowledge production. Notably, the capacity of producing creative hybridization between biotic and abiotic component seems to be the new frontier in the field of technological design and material engineering. The term hypernatural, proposed by Blaine Brownell and Marc Swackhamer in 2015, introduces the idea of a co-evolutionary process between nature and science, looking at humans’ technological capacity as an effective opportunity for creating the conditions for making biotic ad abiotic systems working together: “The ultimate aim of technology is not antinatural: it is hypernatural” (Brownell & Swackhamer in Hyper-natural. Architecture’s new relationship with nature. Princeton Architectural Press, New York, p. 18, 2015). The chapter deals with the methodology applied for promoting a sort of protocological architecture (Burke, 2007), by which facilitating the C&D waste recycle and reuse within the construction sector, and notably into the landscape project. The research starts working under the H2020-Repair project, and it has developed within further research programs about C&D waste management in urban regeneration programs developed by the Department of Architecture of University of Naples Federico II.
APA, Harvard, Vancouver, ISO, and other styles
3

Alina Mofokeng, Maletsema, Zaid Bello, and Kingstone Mashingaidze. "Phenotypic Analysis of Pigeon Pea Reveal Genotypic Variability under Different Environmental Interaction." In Legumes Research - Volume 1. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.99285.

Full text
Abstract:
Pigeon pea is one of the most important leguminous crop globally. However it is a neglected pulse crops in South Africa in terms of research and production. Most farmers grow local landraces with low yields and there is lack of diverse material. The objective of the study was to determine the presence of genetic diversity among the pigeon pea genotypes using quantitative and qualitative phenotypic traits. The trials were conducted in Mafikeng and Nelspruit in South Africa. The trials were laid out in randomised complete block designs replicated three times. The quantitative and qualitative phenotypic data were recorded according to pigeon pea descriptor list. The phenotypic data were analysed using analysis of variance, Pearson’s correlations, principal component analysis, and biplots constructed using principal coordinate analysis, Shannon weaver diversity indices and frequencies. The results showed highly significant differences among the genotypes based on plant height, pod bearing and seed number per pod meaning there was vast genetic diversity among the genotypes. Seed yield was positively correlated with seed number per pod, seed number per plant and pod weight whereas pod bearing was negatively associated with hundred seed weight meaning improving seed yield will automatically improve other positively correlated traits. Principal component analysis showed five most important PCs contributing to a total variation of 84.7%. The traits that contributed to the most variation to the total variation observed were plant height, pod length, seed yield, pod bearing and days to flowering. The Shannon weaver indices ranged between 0.98 and 1.00 showing the presence of variation among the qualitative traits measured. The clustering grouped genotypes into three clusters with Tumia and ICEAP 00540 being the most diverse. The diverse genotypes can be used as parents for hybridization and development of transgressive segregants in breeding programmes. There was vast presence of genetic diversity among the pigeon pea genotypes evaluated.
APA, Harvard, Vancouver, ISO, and other styles
4

Nanang Ali, Sutisna. "Rolling Resistance Estimation for PCR Tyre Design Using the Finite Element Method." In Finite Element Methods and Their Applications [Working Title]. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.94144.

Full text
Abstract:
This study presents rolling resistance estimation in the design process of passenger car radial (PCR) tyre by using finite element method. The rolling resistance coefficient of tyres has been becoming one of main requirements within the regulation in many countries as it is related to the level of allowable exhaust gas emission generated by vehicle. Therefore, the tyre being designed must be digitally simulated using finite element method before the tyre is manufactured to provide a high confident level and avoid unnecessary cost related to failure physical product testing. The simulation firstly computes the deformation of several alternative designs of tyres under certain loading, and then the value of deformation force in each tyre component during deformation took place is calculated. The total force of deformation is considered as energy loss or hysteresis loss resulted in tyre rolling resistance. The experiment was carried out on three different tyre designs: two grooves, three grooves, and four grooves. The four groove tyre design gave the smallest rolling resistance coefficient (RRC). Finally, the simulation was continued to compare different crown radius of the tyres and the result shows that the largest crown radius generates the lowest rolling resistance.
APA, Harvard, Vancouver, ISO, and other styles
5

Brock, Fred V., and Scott J. Richardson. "Anemometry." In Meteorological Measurement Systems. Oxford University Press, 2001. http://dx.doi.org/10.1093/oso/9780195134513.003.0009.

Full text
Abstract:
The function of an anemometer (sometimes with a wind vane) is to measure some or all components of the wind velocity vector. It is common to express the wind as a two-dimensional horizontal vector since the vertical component of the wind speed is usually small near the earth’s surface. In some cases, the vertical component is important and then we think of the wind vector as being three-dimensional. The vector can be written as orthogonal components (u, v, and sometimes w] where each component is the wind speed component blowing in the North, East, or vertically up direction. Alternatively, the vector can be written as a speed and a direction. In the horizontal case, the wind direction is the direction from which the wind is blowing measured in degrees clockwise from North. The wind vector can be expressed in three dimensions as the speed, direction in the horizontal plane as above, and the elevation angle. Standard units for wind speed (a scalar component of the velocity) are m s-1 and knots (nautical miles per hour). Some conversion factors are shown in table 7-1. Wind velocity is turbulent; that is, it is subject to variations in speed, direction, and period. The wind vector can be described in terms of mean flow and gustiness or variation about the mean. The WMO standard defines the mean as the average over 10 minutes. The ideal wind-measuring instrument would respond to the slightest breeze yet be rugged enough to withstand hurricane-force winds, respond to rapidly changing turbulent fluctuations, have a linear output, and exhibit simple dynamic performance characteristics. It is difficult to build sensors that will continue to respond to wind speeds as they approach zero or will survive as wind speeds become very large. Thus a variety of wind sensor designs and, even within a design type, a spectrum of implementations have evolved to meet our needs.
APA, Harvard, Vancouver, ISO, and other styles
6

Turuk, Mladen. "An Overview of Digital Entrepreneurship in Central and Eastern European Countries." In E-Business - Higher Education and Intelligence Applications. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.95961.

Full text
Abstract:
The aim of the study is to explore and present an overview of digital entrepreneurship in Central and Eastern European countries and to examine how certain components of the DESI index affect GDP per capita in CEE countries and in what way modern information technologies affect their economies. The paper uses secondary data sources, mostly scientific and professional journals from the studied area, DESI reports, Eurostat data, and other Internet sources. The first part of the paper presents a short introduction on digitization digital entrepreneurship and digital technologies. The second part provides a descriptive analysis of digital entrepreneurship indicators and explores business demography in the ICT sector while the third part refers to the analysis of the DESI index. The panel method on data from 2015 to 2019 was used to show the influence of the different DESI index components on the observed countries’ GDP per capita. The hypothesis that the components of the DESI index have a positive impact on GDP per capita has been partially confirmed. DESI rank, Connectivity and Human capital did not prove to be significant, while Use of internet services, Integration of digital technology, and Digital public services proved their significant positive effect.
APA, Harvard, Vancouver, ISO, and other styles
7

Mari, TamilSalvi, Sujatavani Gunasagaran, Sivaraman Kuppusamy, and Veronica Ng. "Online Learning Using Game Design." In Handbook of Research on Facilitating Collaborative Learning Through Digital Content and Learning Technologies, 325–42. IGI Global, 2023. http://dx.doi.org/10.4018/978-1-6684-5709-2.ch017.

Full text
Abstract:
This chapter reviews students' online learning experiences in an architecture module: designing a game as the learning outcome. This game design approach uses constructionism theory to analyze the learning process acquired by the students. The study employs a quantitative method. An online survey was used to collect data from a batch of undergraduate architecture students enrolled in a technical module offered online. Most students reported they had a meaningful learning experience. However, the students felt that online learning did not promote successful peer interaction, which is critical for peer learning. The results from this study indicated students preferred to develop better interaction with other students, which is an essential component of learning in architecture education-peer learning. The findings revealed that this pedagogical method could improve architecture students' learning experience and engagement. The findings provide insight on online learning platforms that might change teaching and learning after the pandemic.
APA, Harvard, Vancouver, ISO, and other styles
8

"Introduction." In Food: The Chemistry of its Components, 1–6. 6th ed. The Royal Society of Chemistry, 2015. http://dx.doi.org/10.1039/bk9781849738804-00001.

Full text
Abstract:
The chemists of the eighteenth and nineteenth centuries concentrated their efforts on the detection of food adulteration, detecting harmful ingredients (notably colourings) and protecting government revenue from the effects of the dilution and adulteration of wines and spirits etc. Twentieth century developments in physiology medicine stimulated the development of analytical techniques for proteins, sugars, etc. and also the vitamins and trace elements important in tiny amounts. Nowadays chemists are required to measure pesticide residues etc. at the parts per billion level. Chemists also study the behaviour of food components, during processing and culinary operations and their contribution to flavour, texture appearance as well as nutritional value. This activity is partly driven by the public's desire for the elusive property of “naturalness” in diet and recognition of the interactions between nutrition and sensory appeal.
APA, Harvard, Vancouver, ISO, and other styles
9

Ng, Wing Shui. "Enhancing the Quality of Educational Website Design through Assessment for Learning Strategies." In Advances in Web Technologies and Engineering, 24–51. IGI Global, 2016. http://dx.doi.org/10.4018/978-1-4666-9764-5.ch002.

Full text
Abstract:
To improve the quality of a website, many principles or guidelines have been suggested in the literature. However, the application of related principles is not a straightforward issue. It requires the web developer with high level of self-awareness to continuously review his own works and to justify the design based on related web design principles. The web developer should behave as a reflective practitioner for creating a high-quality website which fulfilled web design principles in various aspects. However, reflection cannot be implicitly assumed as an inborn ability. Certain experiences or training must be provided so as to enable the web designer to develop high level of self-reflection. In this connection, this chapter introduces a series of assessment for learning strategies with self- and peer-assessment components for transforming a web developer into a reflective practitioner. Detailed implementation, its effectiveness and participants' opinions of the self- and peer-assessment strategy of a case study will be reported.
APA, Harvard, Vancouver, ISO, and other styles
10

Ng, Wing Shui. "Enhancing the Quality of Educational Website Design through Assessment for Learning Strategies." In Learning and Performance Assessment, 1106–33. IGI Global, 2020. http://dx.doi.org/10.4018/978-1-7998-0420-8.ch052.

Full text
Abstract:
To improve the quality of a website, many principles or guidelines have been suggested in the literature. However, the application of related principles is not a straightforward issue. It requires the web developer with high level of self-awareness to continuously review his own works and to justify the design based on related web design principles. The web developer should behave as a reflective practitioner for creating a high-quality website which fulfilled web design principles in various aspects. However, reflection cannot be implicitly assumed as an inborn ability. Certain experiences or training must be provided so as to enable the web designer to develop high level of self-reflection. In this connection, this chapter introduces a series of assessment for learning strategies with self- and peer-assessment components for transforming a web developer into a reflective practitioner. Detailed implementation, its effectiveness and participants' opinions of the self- and peer-assessment strategy of a case study will be reported.
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Design per componenti"

1

Ottaviani, Dorotea. "Il valore della memoria nei processi di riqualificazione dei grandi complessi di edilizia residenziale pubblica." In International Conference Virtual City and Territory. Roma: Centre de Política de Sòl i Valoracions, 2014. http://dx.doi.org/10.5821/ctv.8017.

Full text
Abstract:
Come affrontare i processi di riqualificazione quando “il rapporto tra le aree-residenza e elementi primari” non è più alla base della configurazione per tessuti della città e la casa diventa monumentale memoria e gesto rappresentativo dello Stato? Concentrando lo sguardo sul periodo tra gli anni 60' e 70' si rende evidente un intento congiunto delle amministrazioni e degli architetti, attraverso la progettazione di complessi a scala macroscopica, spesso isolati dal contesto classico della città, di creare una visione chiara ed iconica del ruolo assistenzialista dello Stato. Questa stagione, sottolineata da scelte compositive in contrapposizione con la visione “ordinaria” della città e della sua crescita per tessuti, raggiunge la sua massima espressione nel “grande segno” che fa coincidere tipologia architettonica con morfologia urbana e racconta di un’amministrazione che vuole essere il referente diretto per la risoluzione di problematiche sociali e risponde in maniera reattiva e molto rapida alle questioni e alle esigenze poste dalle sue classi più bisognose. Il primo valore da riconoscere ai progetti di questo periodo è di essere stati rappresentativi di vocazioni collettive e di averle riassunte con un gesto progettuale dall'alto valore iconografico. La seconda caratteristica di questa stagione architettonica, continuando a restringere la valutazione ad una constatazione dei fatti scevra di componenti di giudizio, è la sua ampia vocazione ad essere terreno sperimentale sia in ambiti architettonici che urbanistici. La domanda che ci poniamo è se sia possibile ripartire da queste due valori per re-interpretare i progetti dei grandi complessi residenziali pubblici e renderli “abitabili” mantenendone le loro particolari vocazioni. How can we deal with requalification process in parts of the city which are no longer based on the “relation among residential-area and primary elements” and where the house has become the rappresentative memory of programs and ideals of the State? Concentrating on the 60' and 70' period in Italy it is clear a joined intent of the administration and the architects to create a neat and iconographic image of the protective and directive role of the State towards its citizen, through the designing of large, unitary social housing, often off the normal urban scale and isolated by the rest of the city. This season, highlighted by compositive experience in sharp contrapposition with the “ordinary” vision of the city, reach its maximal expression in “great sign design” that tends to an equivalence between architectural typology and urban morphology. The first merit that have to be acknowlegde to those project is to have been a representative of collective vocations through a high valued iconographical design. A second valor to be confered to this period is its vocation on being a laboratory for both architectural and urban experimentation. Question we are facing is, then, if it is possibile to start over on those two intrinsic values, seep through the lens of the european directives for sustainable renewal of the cities, for a reinterpretation of the large housing estates in order to give them back to their peculiar potential and to make the the center of regenerations of the city itself.
APA, Harvard, Vancouver, ISO, and other styles
2

Parashar, Tarang, Katie Grantham Lough, and Robert B. Stone. "The Part Count Tool (PACT) for Concept Selection." In ASME 2009 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2009. http://dx.doi.org/10.1115/detc2009-87547.

Full text
Abstract:
This paper presents a part count tool that automates the consideration of manufacturing cost during the conceptual design phase by predicting part count for a particular product concept. With an approximate number of parts per product in the conceptual design phase, the designer can estimate the cost associated with the product. On the basis of the cost, the designer can make changes according to budget requirements. The part count tool will also aid in ranking the design concepts by number of components for a product. This tool utilizes existing automated concept generation algorithms to generate the design concepts. It extracts the available data from the Missouri S&T Design Repository to compute an average number of parts per component type in the repository and then calculates an average part count for new concepts. This data can subsequently be used by designers to estimate product cost. The part count tool also uses an algorithm to determine how to connect two non compatible components through the addition of mutually compatible components. While emphasis is placed on the average parts per product in evaluating designs, the overall functional requirement of the product is also considered.
APA, Harvard, Vancouver, ISO, and other styles
3

Kowalczyk, Marcin, and Tomasz Kryjak. "A Connected Component Labelling algorithm for a multi-pixel per clock cycle video stream." In 2021 24th Euromicro Conference on Digital System Design (DSD). IEEE, 2021. http://dx.doi.org/10.1109/dsd53832.2021.00016.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Fagade, Adekunle A., and David Kazmer. "Optimal Component Consolidation in Molded Product Design." In ASME 1999 Design Engineering Technical Conferences. American Society of Mechanical Engineers, 1999. http://dx.doi.org/10.1115/detc99/dfm-8921.

Full text
Abstract:
Abstract Per standard DFMA practice, designers are taking advantage of the full capability of manufacturing processes by consolidating multiple parts and functions into fewer, more complex parts. This paper examines the component consolidation issues for injection molded parts. Detailed tooling cost and lead-time models are first developed from industry data; material and processing cost models are established based on analytic and empirical models. Differential calculus is then applied to a generic profit model to establish nonspecific guidelines for component consolidation for both a single and mix of products. A quantitative demonstration of these concepts is also provided for a family of complex internal chassis. The results indicate that some additional DFMA rules are necessary regarding component consolidation. Components should not be combined if: the consolidation does not reduce the number of tools, the components have vastly different quality requirements, the design process is not certain of delivering the product and there is significant sales cost sensitivity, and the manufacturing processes are not capable of delivering high yields of complex products.
APA, Harvard, Vancouver, ISO, and other styles
5

Fortune, Benjamin C., Lachlan R. McKenzie, Logan T. Chatfield, and Christopher G. Pretty. "Electrode-Skin Impedance Component Estimation in the Time-Domain." In ASME 2019 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/detc2019-98298.

Full text
Abstract:
Abstract This paper presents a method to estimate the individual component values of a bipolar electrode-skin interface, with future intent of applying compensatory electrode-skin impedance balancing prior recording bio-signals with electromyography. The electrode-skin interface was stimulated by a step input and the output behaviour was characterised using a single exponential model per electrode. The method was applied to simulated circuitry, passive component circuitry and a human subject. The accuracy of the method was determined using the known values that comprised the simulated and passive component circuitry. Nine of ten simulated data sets resulted in accurate estimations, with a maximum error of 0.763% and a mean error of 0.076% per component. The method also produced successful estimates for nine of the ten physical circuitry data sets, with a maximum error of 10.2% and a mean error of 3.49% per component. The method was unsuccessful in estimating the individual electrode-skin impedance components for the human subject: this was due to the system failing to reach steady state during the stimulation period. The authors suspect a DC offset caused by the half-cell potentials associated with the electrode-skin interface were the cause of the unexpected behaviour.
APA, Harvard, Vancouver, ISO, and other styles
6

Whitney, Daniel E., Qi Dong, Jared Judson, and Gregory Mascoli. "Introducing Knowledge-Based Engineering Into an Interconnected Product Development Process." In ASME 1999 Design Engineering Technical Conferences. American Society of Mechanical Engineers, 1999. http://dx.doi.org/10.1115/detc99/dtm-8741.

Full text
Abstract:
Abstract Recently, a large automobile company implemented a Knowledge-based Engineering (KBE) application to help design an engine component. While the KBE developers aimed to facilitate a single engineer’s ability to design this component using only the KBE application, it can be shown that in fact this component’s design is tightly coupled to that of several others. Can KBE handle situations like this? How common are they? To address these and other questions, Design Structure Matrix (DSM) models were made of this component at three levels: system interactions, assembly of the component, and individual parts. The size, row names, and internal entries of these matrices were compared to matrices constructed from several conventional written design guides and a flowchart of the KBE application. In each case, the DSM contained more rows or more matrix entries per row, especially at the system interaction level. Since the DSMs were constructed by interviewing experienced engineers, one implication is that while low-aggregation information may be documented, system level information at this company mostly resides in people’s heads. An informal measure of “knowledge content” based on the number of matrix entries per row was shown to be consistent with similar measurements made on DSMs obtained by several other researchers. These results indicate some of the scope and complexity challenges that KBE faces.
APA, Harvard, Vancouver, ISO, and other styles
7

Karania, Ruchi, David Kazmer, and Christoph Roser. "Plastics Product and Process Design Strategies." In ASME 2004 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2004. http://dx.doi.org/10.1115/detc2004-57755.

Full text
Abstract:
Plastic components are vital components of many engineered products, frequently representing 20–40% of the product value. While injection molding is the most common process for economically producing complex designs in large quantities, a large initial monetary investment is required to develop appropriate tooling. Accordingly, injection molding may not be appropriate for applications that are not guaranteed to recoup the initial costs. In this paper, component cost and lead-time models are developed from industry data for an electrical enclosure consisting of two parts produced by a variety of low to medium volume manufacturing processes including fused deposition modeling, direct fabrication, and injection molding with used tooling, soft prototype tooling, and hard tooling. The viability of each process is compared with respect to the manufacturing cost and lead time for specific production quantities of one hundred, one thousand, and ten thousand. The results indicate that the average cost per enclosure assembly is highly sensitive to the production quantity, varying in range from $243 per enclosure for quantity one hundred to $0.52 per enclosure for quantity ten thousand. The most appropriate process varies greatly with the desired production quantity and cost/lead time sensitivity. As such, a probabilistic analysis was utilized to evaluate the effect of uncertain demand and market delays, the result of which demonstrated the importance of maintaining supply chain flexibility by minimizing initial cost and lead time.
APA, Harvard, Vancouver, ISO, and other styles
8

Semos, A., and C. Chassapis. "A Finite Element Formulation for the Dynamic Analysis of Machine Components Fabricated From Composite Materials." In ASME 1992 Design Technical Conferences. American Society of Mechanical Engineers, 1992. http://dx.doi.org/10.1115/detc1992-0223.

Full text
Abstract:
Abstract In this paper finite element procedures are presented for analyzing the elastic-dynamic behavior of mechanical components fabricated from fiber-reinforced composite materials. An arbitrarily laminated composite plate element is created which allows the analysis of components that are moving in three dimensional space. The five D.O.F. per node static model of S. C. Panda and R. Natarajan is used as a basis for the derivation of the dynamic model. The elemental equations of motion are derived from Hamilton’s Principle. The formulation considers the total kinetic and strain energies of the moving element, together with the work due to bending, caused by the transversely acting external forces, as well as that due to the foreshortening of the element, caused by axially applied loads.
APA, Harvard, Vancouver, ISO, and other styles
9

Modaresifar, Masoud, Mansour Zenouzi, and Gregory J. Kowalski. "Performance Comparisons of Solar Desalination Devices and Processes." In ASME 2012 6th International Conference on Energy Sustainability collocated with the ASME 2012 10th International Conference on Fuel Cell Science, Engineering and Technology. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/es2012-91517.

Full text
Abstract:
Numerical analysis of two passive solar desalination designs, the traditional pool evaporation design and the proposed tray design are performed. The significance of common assumption for the pool evaporation design that neglect the mass balance and psychrometric relationships for the air-water vapor volume were investigated and found that neglecting this component results in over predicting the freshwater production by 32.6% and 19.5% for the summer and winter design day, respectively. It was also found that the tray design produced 31.3 % and 7% more freshwater per summer and winter design day, respectively. These results support the need to include all physical components in the numerical simulation. The results also support the tray design as producing significantly more freshwater for the same input.
APA, Harvard, Vancouver, ISO, and other styles
10

Adley, J., M. Jones, S. Stole, D. Perettie, and R. Fox. "Design and Material Synergy for High-Performance Actuator Components." In ASME 1998 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1998. http://dx.doi.org/10.1115/imece1998-0202.

Full text
Abstract:
Abstract The continuing magnetic disk drive storage industry goals of higher recorded data densities will require increases in tracks per inch (TPI) which will ultimately demand changes in designs/or materials. Rotary actuators represent one application whose configuration and material composition can influence disk drive performance through projected enhancements in tracking accuracy. Ceramic-metal composites allow specific component geometries to be altered to take advantage of the new material properties. This synergistic approach to design and materials allows a much greater improvement to the mechanical performance of actuator components than either material or design substitution alone would allow. This work describes both the fabrication of Aluminum-Boron Carbide reacted metal matrix materials and their practical implementation with specific design strategies developed through numerical models to achieve high performance head/suspension/actuator structure assemblies. Improvements in the overall frequency response behavior of the head support structure are contrasted with equivalent example configurations of conventional materials through simulations which have been experimentally verified.
APA, Harvard, Vancouver, ISO, and other styles

Reports on the topic "Design per componenti"

1

Sowa, Patience, Rachel Jordan, Wendi Ralaingita, and Benjamin Piper. Higher Grounds: Practical Guidelines for Forging Learning Pathways in Upper Primary Education. RTI Press, May 2021. http://dx.doi.org/10.3768/rtipress.2021.op.0069.2105.

Full text
Abstract:
To address chronically low primary school completion rates and the disconnect between learners’ skills at the end of primary school and the skills learners need to thrive in secondary school identified in many low- and middle-income countries, more investment is needed to improve the quality of teaching and learning in upper primary grades. Accordingly, we provide guidelines for improving five components of upper primary education: (1) In-service teacher professional development and pre-service preparation to improve and enhance teacher quality; (2) a focus on mathematics, literacy, and core content-area subjects; (3) assessment for learning; (4) high-quality teaching and learning materials; and (5) positive school climates. We provide foundational guiding principles and recommendations for intervention design and implementation for each component. Additionally, we discuss and propose how to structure and design pre-service teacher preparation and in-service teacher training and ongoing support, fortified by materials design and assessment, to help teachers determine where learners are in developmental progressions, move learners towards mastery, and differentiate and support learners who have fallen behind. We provide additional suggestions for integrating a whole-school climate curriculum, social-emotional learning, and school-related gender-based violence prevention strategies to address the internal and societal changes learners often face as they enter upper primary.
APA, Harvard, Vancouver, ISO, and other styles
2

McEntee, Alice, Sonia Hines, Joshua Trigg, Kate Fairweather, Ashleigh Guillaumier, Jane Fischer, Billie Bonevski, James A. Smith, Carlene Wilson, and Jacqueline Bowden. Tobacco cessation in CALD communities. The Sax Institute, June 2022. http://dx.doi.org/10.57022/sneg4189.

Full text
Abstract:
Background Australia is a multi-cultural society with increasing rates of people from culturally and linguistically diverse (CALD) backgrounds. On average, CALD groups have higher rates of tobacco use, lower participation in cancer screening programs, and poorer health outcomes than the general Australian population. Lower cancer screening and smoking cessation rates are due to differing cultural norms, health-related attitudes, and beliefs, and language barriers. Interventions can help address these potential barriers and increase tobacco cessation and cancer screening rates among CALD groups. Cancer Council NSW (CCNSW) aims to reduce the impact of cancer and improve cancer outcomes for priority populations including CALD communities. In line with this objective, CCNSW commissioned this rapid review of interventions implemented in Australia and comparable countries. Review questions This review aimed to address the following specific questions: Question 1 (Q1): What smoking cessation interventions have been proven effective in reducing or preventing smoking among culturally and linguistically diverse communities? Question 2 (Q2): What screening interventions have proven effective in increasing participation in population cancer screening programs among culturally and linguistically diverse populations? This review focused on Chinese-, Vietnamese- and Arabic-speaking people as they are the largest CALD groups in Australia and have high rates of tobacco use and poor screening adherence in NSW. Summary of methods An extensive search of peer-reviewed and grey literature published between January 2013-March 2022 identified 19 eligible studies for inclusion in the Q1 review and 49 studies for the Q2 review. The National Health and Medical Research Council (NHMRC) Levels of Evidence and Joanna Briggs Institute’s (JBI) Critical Appraisal Tools were used to assess the robustness and quality of the included studies, respectively. Key findings Findings are reported by components of an intervention overall and for each CALD group. By understanding the effectiveness of individual components, results will demonstrate key building blocks of an effective intervention. Question 1: What smoking cessation interventions have been proven effective in reducing or preventing smoking among culturally and linguistically diverse communities? Thirteen of the 19 studies were Level IV (L4) evidence, four were Level III (L3), one was Level II (L2), none were L1 (highest level of evidence) and one study’s evidence level was unable to be determined. The quality of included studies varied. Fifteen tobacco cessation intervention components were included, with most interventions involving at least three components (range 2-6). Written information (14 studies), and education sessions (10 studies) were the most common components included in an intervention. Eight of the 15 intervention components explored had promising evidence for use with Chinese-speaking participants (written information, education sessions, visual information, counselling, involving a family member or friend, nicotine replacement therapy, branded merchandise, and mobile messaging). Another two components (media campaign and telephone follow-up) had evidence aggregated across CALD groups (i.e., results for Chinese-speaking participants were combined with other CALD group(s)). No intervention component was deemed of sufficient evidence for use with Vietnamese-speaking participants and four intervention components had aggregated evidence (written information, education sessions, counselling, nicotine replacement therapy). Counselling was the only intervention component to have promising evidence for use with Arabic-speaking participants and one had mixed evidence (written information). Question 2: What screening interventions have proven effective in increasing participation in population cancer screening programs among culturally and linguistically diverse populations? Two of the 49 studies were Level I (L1) evidence, 13 L2, seven L3, 25 L4 and two studies’ level of evidence was unable to be determined. Eighteen intervention components were assessed with most interventions involving 3-4 components (range 1-6). Education sessions (32 studies), written information (23 studies) and patient navigation (10 studies) were the most common components. Seven of the 18 cancer screening intervention components had promising evidence to support their use with Vietnamese-speaking participants (education sessions, written information, patient navigation, visual information, peer/community health worker, counselling, and peer experience). The component, opportunity to be screened (e.g. mailed or handed a bowel screening test), had aggregated evidence regarding its use with Vietnamese-speaking participants. Seven intervention components (education session, written information, visual information, peer/community health worker, opportunity to be screened, counselling, and branded merchandise) also had promising evidence to support their use with Chinese-speaking participants whilst two components had mixed (patient navigation) or aggregated (media campaign) evidence. One intervention component for use with Arabic-speaking participants had promising evidence to support its use (opportunity to be screened) and eight intervention components had mixed or aggregated support (education sessions, written information, patient navigation, visual information, peer/community health worker, peer experience, media campaign, and anatomical models). Gaps in the evidence There were four noteworthy gaps in the evidence: 1. No systematic review was captured for Q1, and only two studies were randomised controlled trials. Much of the evidence is therefore based on lower level study designs, with risk of bias. 2. Many studies provided inadequate detail regarding their intervention design which impacts both the quality appraisal and how mixed finding results can be interpreted. 3. Several intervention components were found to have supportive evidence available only at the aggregate level. Further research is warranted to determine the interventions effectiveness with the individual CALD participant group only. 4. The evidence regarding the effectiveness of certain intervention components were either unknown (no studies) or insufficient (only one study) across CALD groups. This was the predominately the case for Arabic-speaking participants for both Q1 and Q2, and for Vietnamese-speaking participants for Q1. Further research is therefore warranted. Applicability Most of the intervention components included in this review are applicable for use in the Australian context, and NSW specifically. However, intervention components assessed as having insufficient, mixed, or no evidence require further research. Cancer screening and tobacco cessation interventions targeting Chinese-speaking participants were more common and therefore showed more evidence of effectiveness for the intervention components explored. There was support for cancer screening intervention components targeting Vietnamese-speaking participants but not for tobacco cessation interventions. There were few interventions implemented for Arabic-speaking participants that addressed tobacco cessation and screening adherence. Much of the evidence for Vietnamese and Arabic-speaking participants was further limited by studies co-recruiting multiple CALD groups and reporting aggregate results. Conclusion There is sound evidence for use of a range of intervention components to address tobacco cessation and cancer screening adherence among Chinese-speaking populations, and cancer screening adherence among Vietnamese-speaking populations. Evidence is lacking regarding the effectiveness of tobacco cessation interventions with Vietnamese- and Arabic-speaking participants, and cancer screening interventions for Arabic-speaking participants. More research is required to determine whether components considered effective for use in one CALD group are applicable to other CALD populations.
APA, Harvard, Vancouver, ISO, and other styles
3

Cobeen, Kelly, Vahid Mahdavifar, Tara Hutchinson, Brandon Schiller, David Welch, Grace Kang, and Yousef Bozorgnia. Large-Component Seismic Testing for Existing and Retrofitted Single-Family Wood-Frame Dwellings (PEER-CEA Project). Pacific Earthquake Engineering Research Center, University of California, Berkeley, CA, November 2020. http://dx.doi.org/10.55461/hxyx5257.

Full text
Abstract:
This report is one of a series of reports documenting the methods and findings of a multi-year, multi-disciplinary project coordinated by the Pacific Earthquake Engineering Research Center (PEER and funded by the California Earthquake Authority (CEA). The overall project is titled “Quantifying the Performance of Retrofit of Cripple Walls and Sill Anchorage in Single-Family Wood-Frame Buildings,” henceforth referred to as the “PEER–CEA Project.” The overall objective of the PEER–CEA Project is to provide scientifically based information (e.g., testing, analysis, and resulting loss models) that measure and assess the effectiveness of seismic retrofit to reduce the risk of damage and associated losses (repair costs) of wood-frame houses with cripple wall and sill anchorage deficiencies as well as retrofitted conditions that address those deficiencies. Tasks that support and inform the loss-modeling effort are: (1) collecting and summarizing existing information and results of previous research on the performance of wood-frame houses; (2) identifying construction features to characterize alternative variants of wood-frame houses; (3) characterizing earthquake hazard and ground motions at representative sites in California; (4) developing cyclic loading protocols and conducting laboratory tests of cripple wall panels, wood-frame wall subassemblies, and sill anchorages to measure and document their response (strength and stiffness) under cyclic loading; and (5) the computer modeling, simulations, and the development of loss models as informed by a workshop with claims adjustors. Quantifying the difference of seismic performance of un-retrofitted and retrofitted single-family wood-frame houses has become increasingly important in California due to the high seismicity of the state. Inadequate lateral bracing of cripple walls and inadequate sill bolting are the primary reasons for damage to residential homes, even in the event of moderate earthquakes. Physical testing tasks were conducted by Working Group 4 (WG4), with testing carried out at the University of California San Diego (UCSD) and University of California Berkeley (UCB). The primary objectives of the testing were as follows: (1) development of descriptions of load-deflection behavior of components and connections for use by Working Group 5 in development of numerical modeling; and (2) collection of descriptions of damage at varying levels of peak transient drift for use by Working Group 6 in development of fragility functions. Both UCSD and UCB testing included companion specimens tested with and without retrofit. This report documents the portions of the WG4 testing conducted at UCB: two large-component cripple wall tests (Tests AL-1 and AL-2), one test of cripple wall load-path connections (Test B-1), and two tests of dwelling superstructure construction (Tests C-1 and C-2). Included in this report are details of specimen design and construction, instrumentation, loading protocols, test data, testing observations, discussion, and conclusions.
APA, Harvard, Vancouver, ISO, and other styles
4

Snijder, Mieke, and Marina Apgar, J. How Does Participatory Action Research Generate Innovation? Findings from a Rapid Realist Review. Institute of Development Studies (IDS), July 2021. http://dx.doi.org/10.19088/clarissa.2021.009.

Full text
Abstract:
This Emerging Evidence Report shares evidence of how, for whom, and under what circumstances, Participatory Action Research (PAR) leads to innovative actions. A rapid realist review was undertaken to develop programme theories that explain how PAR generates innovation. The methodology included peer-reviewed and grey literature and moments of engagement with programme staff, such that their input supported the development and refinement of three resulting initial programme theories (IPTs) that we present in this report. Across all three IPTs, safe relational space, group facilitation, and the abilities of facilitators, are essential context and intervention components through which PAR can generate innovation. Implications from the three IPTs for evaluation design of the CLARISSA programme are identified and discussed. The report finishes with opportunities for the CLARISSA programme to start building an evidence base of how PAR works as an intervention modality, such as evidencing group-level conscientisation, the influence of intersecting inequalities, and influence of diverse perspectives coming together in a PAR process.
APA, Harvard, Vancouver, ISO, and other styles
5

Clevenger, Anthony P., and Adam T. Ford. A before-after-control-impact study of wildlife fencing along a highway in the Canadian Rocky Mountains. Nevada Department of Transportation, February 2022. http://dx.doi.org/10.15788/ndot2022.02.

Full text
Abstract:
Wildlife exclusion fencing has become a standard component of highway mitigation systems designing to reduce collisions with large mammals. Past work on the effectiveness of exclusion fencing has relied heavily on control-impact (i.e., space-for-time substitutions) and before-after study designs. These designs limit inference and may confound the effectiveness of mitigation with co-occurring process that also change the rate of collisions. We used a replicated before-after-control-impact study design to assess fencing effectiveness along the Trans-Canada Highway in the Rocky Mountains of Canada. We found that collisions declined for common ungulates species (elk, mule deer and white-tailed deer) by up to 96% but not for large carnivores. The weak response of carnivores is likely due to combination of fence intrusions and low sample sizes. When accounting for background changes in collision rates observed at control sites, naïve estimates of fencing effectiveness declined by 6% at one site to 90% and increased by 10% at another to a realized effectiveness of 82%. When factoring in the cost of ungulate collisions to society as a whole, fencing provided a net economic gain within 1 year of construction. Over a 10-year period, fencing would provide a net economic gain of >$500,000 per km in reduced collisions. In contrast, control site may take upwards of 90 years before the background rates of collisions decline to a break even point. Our study highlights the benefits of long-term monitoring of road mitigation projects and provides evidence of fencing effectiveness for reducing wildlife-vehicle collisions involving large mammals.
APA, Harvard, Vancouver, ISO, and other styles
6

Erdman, Richard, Geoffrey Dahl, Hanina Barash, Israel Bruckental, Avi Shamay, and Anthony Capuco. Management Strategies to Maximize Skeletal Growth Rate in Dairy Heifers. United States Department of Agriculture, July 2002. http://dx.doi.org/10.32747/2002.7695848.bard.

Full text
Abstract:
The objectives of this study were to determine the effects of recombinant bovine somatotropin (bST) and added dietary rumen undegradable protein (RUP) on organ and tissue weights and body composition in growing dairy heifers. A total of 32 Holstein heifers, 3 months of age at the beginning of the study were used in the experiment. Eight heifers were slaughtered at 3 mo of age to determine pre- treatment body composition. The remaining heifers were randomly assigned to treatments (n=6) consisting of 0.1 mg/kg body weight per day of bST and 2% added dietary RUP (dry matter basis) applied in a 2X2 factorial design. A total of six heifers per treatment group (3 each at 5 and 10 mo of age), were slaughtered to determine body composition an organ masses. There was a trend for increased live and empty body weights (EB:W), carcass and non-carcass components for heifers treated with bST or fed RUP. Added RUP increased rumen and reticulum weights whereas administration of bST tended to increase the weights of small and large intestine at 10 months of age by 22 % and 26%, respectively. Spleen, heart, and kidney weights at 10 months of age were increased 36%, 28% and 23% for bST treatments respectively, compared with controls. Rates of ash and protein deposition between 3 and 10 months of age were increased by bST by 7.2 g/d and 28.9 g/d, respectively, while no treatment differences were observed for rates of fat and energy deposition. Bovine somatotropin significantly altered the metabolism of growing heifers in a manner that led to increased protein and ash deposition, and tended to reduce fat percentage, and there was a similar tendency observed with added RUP. This suggests that nutritional and endocrine manipulations could increase growth rates of skeletal and lean tissues without increasing fat deposition in prepubertal dairy heifers.
APA, Harvard, Vancouver, ISO, and other styles
7

Carter, Becky. Inclusion in Crisis Response, Recovery and Resilience. Institute of Development Studies (IDS), May 2021. http://dx.doi.org/10.19088/k4d.2021.079.

Full text
Abstract:
This rapid review provides examples of what has worked to include people in humanitarian assistance who experience heightened vulnerability during crises, due to social inequalities and discrimination relating to gender, age, disability, sexual orientation, gender identity and/or expression, and sex characteristics; and religious belief . Overall, robust evidence is limited for what are, in most cases, relatively new areas of practice in challenging crisis situations. However, the literature does identify promising practices. Emerging themes from the research on what has potential for improving inclusion in humanitarian assistance include: affected people’s meaningful participation in intervention planning and design; whole-of-community approaches while maintaining accountability to the targeted beneficiaries; multi-component approaches combining complementary strategies (e.g. economic empowerment with social norms change programming); longer-term, pre-crisis investment in relationships with, and capacity building of, local organisations; and disaggregating data and undertaking intersectional analyses to include those hardest to reach.
APA, Harvard, Vancouver, ISO, and other styles
8

DiAngelo, Lucy, Libby Lowry, Kayla McDaniel, Clare Sauser, Shelby Terry, and Erin Williams. Increasing Confidence and Mental Health in Caregivers. University of Tennessee Health Science Center, May 2021. http://dx.doi.org/10.21007/chp.mot2.2021.0011.

Full text
Abstract:
The purpose of our critically appraised topic is to synthesize the highest-level evidence available regarding interventions for increasing confidence and mental health outcomes in caregivers taking loved ones home from inpatient rehabilitation. The final portfolio contains six research articles from peer-reviewed journals. Study designs include randomized control trials, a systematic review, and a pretest-posttest without a control group. All studies relate directly to the components of the PICO question. Four of the articles discussed both caregiver confidence and mental health while two articles discussed only mental health. There is strong evidence to support that in-person hands on training, in person discussion-based training, and/or virtual resources helped increase confidence in caregivers of patients. There is mixed evidence and only limited improvement to support mental health. The findings from this critically appraised topic will be used to draft new ideas for practice guidelines for addressing caregiver education and caregiver mental health in an inpatient rehabilitation facility.
APA, Harvard, Vancouver, ISO, and other styles
9

Altstein, Miriam, and Ronald J. Nachman. Rational Design of Insect Control Agent Prototypes Based on Pyrokinin/PBAN Neuropeptide Antagonists. United States Department of Agriculture, August 2013. http://dx.doi.org/10.32747/2013.7593398.bard.

Full text
Abstract:
The general objective of this study was to develop rationally designed mimetic antagonists (and agonists) of the PK/PBAN Np class with enhanced bio-stability and bioavailability as prototypes for effective and environmentally friendly pest insect management agents. The PK/PBAN family is a multifunctional group of Nps that mediates key functions in insects (sex pheromone biosynthesis, cuticular melanization, myotropic activity, diapause and pupal development) and is, therefore, of high scientific and applied interest. The objectives of the current study were: (i) to identify an antagonist biophores (ii) to develop an arsenal of amphiphilic topically active PK/PBAN antagonists with an array of different time-release profiles based on the previously developed prototype analog; (iii) to develop rationally designed non-peptide SMLs based on the antagonist biophore determined in (i) and evaluate them in cloned receptor microplate binding assays and by pheromonotropic, melanotropic and pupariation in vivo assays. (iv) to clone PK/PBAN receptors (PK/PBAN-Rs) for further understanding of receptor-ligand interactions; (v) to develop microplate binding assays for screening the above SMLs. In the course of the granting period A series of amphiphilic PK/PBAN analogs based on a linear lead antagonist from the previous BARD grant was synthesized that incorporated a diverse array of hydrophobic groups (HR-Suc-A[dF]PRLa). Others were synthesized via the attachment of polyethylene glycol (PEG) polymers. A hydrophobic, biostablePK/PBAN/DH analog DH-2Abf-K prevented the onset of the protective state of diapause in H. zea pupae [EC50=7 pmol/larva] following injection into the preceding larval stage. It effectively induces the crop pest to commit a form of ‘ecological suicide’. Evaluation of a set of amphiphilic PK analogs with a diverse array of hydrophobic groups of the formula HR-Suc-FTPRLa led to the identification of analog T-63 (HR=Decyl) that increased the extent of diapause termination by a factor of 70% when applied topically to newly emerged pupae. Another biostablePK analog PK-Oic-1 featured anti-feedant and aphicidal properties that matched the potency of some commercial aphicides. Native PK showed no significant activity. The aphicidal effects were blocked by a new PEGylated PK antagonist analog PK-dF-PEG4, suggesting that the activity is mediated by a PK/PBAN receptor and therefore indicative of a novel and selective mode-of-action. Using a novel transPro mimetic motif (dihydroimidazole; ‘Jones’) developed in previous BARD-sponsored work, the first antagonist for the diapause hormone (DH), DH-Jo, was developed and shown to block over 50% of H. zea pupal diapause termination activity of native DH. This novel antagonist development strategy may be applicable to other invertebrate and vertebrate hormones that feature a transPro in the active core. The research identifies a critical component of the antagonist biophore for this PK/PBAN receptor subtype, i.e. a trans-oriented Pro. Additional work led to the molecular cloning and functional characterization of the DH receptor from H. zea, allowing for the discovery of three other DH antagonist analogs: Drosophila ETH, a β-AA analog, and a dF analog. The receptor experiments identified an agonist (DH-2Abf-dA) with a maximal response greater than native DH. ‘Deconvolution’ of a rationally-designed nonpeptide heterocyclic combinatorial library with a cyclic bis-guanidino (BG) scaffold led to discovery of several members that elicited activity in a pupariation acceleration assay, and one that also showed activity in an H. zea diapause termination assay, eliciting a maximal response of 90%. Molecular cloning and functional characterization of a CAP2b antidiuretic receptor from the kissing bug (R. prolixus) as well as the first CAP2b and PK receptors from a tick was also achieved. Notably, the PK/PBAN-like receptor from the cattle fever tick is unique among known PK/PBAN and CAP2b receptors in that it can interact with both ligand types, providing further evidence for an evolutionary relationship between these two NP families. In the course of the granting period we also managed to clone the PK/PBAN-R of H. peltigera, to express it and the S. littoralis-R Sf-9 cells and to evaluate their interaction with a variety of PK/PBAN ligands. In addition, three functional microplate assays in a HTS format have been developed: a cell-membrane competitive ligand binding assay; a Ca flux assay and a whole cell cAMP ELISA. The Ca flux assay has been used for receptor characterization due to its extremely high sensitivity. Computer homology studies were carried out to predict both receptor’s SAR and based on this analysis 8 mutants have been generated. The bioavailability of small linear antagonistic peptides has been evaluated and was found to be highly effective as sex pheromone biosynthesis inhibitors. The activity of 11 new amphiphilic analogs has also been evaluated. Unfortunately, due to a problem with the Heliothis moth colony we were unable to select those with pheromonotropic antagonistic activity and further check their bioavailability. Six peptides exhibited some melanotropic antagonistic activity but due to the low inhibitory effect the peptides were not further tested for bioavailability in S. littoralis larvae. Despite the fact that no new antagonistic peptides were discovered in the course of this granting period the results contribute to a better understanding of the interaction of the PK/PBAN family of Nps with their receptors, provided several HT assays for screening of libraries of various origin for presence of PK/PBAN-Ragonists and antagonists and provided important practical information for the further design of new, peptide-based insecticide prototypes aimed at the disruption of key neuroendocrine physiological functions in pest insects.
APA, Harvard, Vancouver, ISO, and other styles
10

Kharkivska, Alla A., Liudmyla V. Shtefan, Muntasir Alsadoon, and Aleksandr D. Uchitel. Technology of forming future journalists' social information competence in Iraq based on the use of a dynamic pedagogical site. [б. в.], July 2020. http://dx.doi.org/10.31812/123456789/3853.

Full text
Abstract:
The article reveals scientific approaches to substantiating and developing technology to form social information competence of future Iraqi journalists based on using a dynamic pedagogical site. After pre-interviewing students of the Journalism Faculty at Al-Imam Al-Kadhim University College for Islamic Sciences in Baghdad, the authors came to the conclusion there are issues on defining the essence of social information competences. It is established that the majority of respondents do not feel satisfied with the conditions for forming these competences in the education institutions. At the same time, there were also positive trends as most future journalists recognized the importance of these professional competences for their professional development and had a desire to attend additional courses, including distance learning ones. Subsequently, the authors focused on social information competence of future journalists, which is a key issue according to European requirements. The authors describe the essence of this competence as an integrative quality of personality, which characterizes an ability to select, transform information and allows to organize effective professional communication on the basis of the use of modern communicative technologies in the process of individual or team work. Based on the analysis of literary sources, its components are determined: motivational, cognitive, operational and personal. The researchers came to the conclusion that it is necessary to develop a technology for forming social information competence of future journalists based on the use of modern information technologies. The necessity of technology implementation through the preparatory, motivational, operational and diagnostic correction stages was substantiated and its model was developed. The authors found that the main means of technology implementation should be a dynamic pedagogical site, which, unlike static, allows to expand technical possibilities by using such applications as photo galleries, RSS modules, forums, etc. Technically, it can be created using Site builder. Further research will be aimed at improving the structure of the dynamic pedagogical site of the developed technology.
APA, Harvard, Vancouver, ISO, and other styles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography