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Author: Grafiati

Published: 10 March 2023

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1

Hwang, Anita M., and Jimmy K. Lee. "Descemet-stripping Automated Endothelial Keratoplasty—A Review." US Ophthalmic Review 04, no. 01 (2011): 80. http://dx.doi.org/10.17925/usor.2011.04.01.80.

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Descemet-stripping automated endothelial keratoplasty (DSAEK) has become the procedure of choice to treat corneal endothelial dysfunction. The technique involves replacing the diseased host endothelium with a graft consisting of a thin layer of posterior stroma, Descemet membrane, and endothelium. In comparison to penetrating keratoplasty (PK), DSAEK confers quicker visual and structural recovery with absence of corneal surface incisions or sutures, and limits astigmatism. DSAEK has been proved to successfully achieve favorable visual acuity and graft clarity in bullous keratopathy, posterior polymorphous dystrophy, and failed PK grafts. This article discusses various DSAEK surgical techniques, short- and longterm post-surgical results, complications, and comparisons with other types of keratoplasty. With the advent of Descemet membrane endothelial keratoplasty (DMEK), in which only Descemet membrane is transplanted, visual rehabilitation may be attained sooner.

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2

Gorovoy, Mark S. "Descemet-Stripping Automated Endothelial Keratoplasty." Cornea 40, no. 3 (March 2021): 270–73. http://dx.doi.org/10.1097/ico.0000000000002688.

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3

Alqudah, Asem A., Alex J. Bauer, Michael D. Straiko, P. James Sanchez, and Mark A. Terry. "Descemet Stripping Automated Endothelial Keratoplasty." Medicine 99, no. 45 (November 6, 2020): e23139. http://dx.doi.org/10.1097/md.0000000000023139.

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4

Ide, Takeshi, Sonia H. Yoo, James M. Goldman, Victor Perez, and Terrence P. OʼBrien. "Descemet-Stripping Automated Endothelial Keratoplasty." Cornea 26, no. 9 (October 2007): 1079–81. http://dx.doi.org/10.1097/ico.0b013e318142bdde.

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5

Chen, Edwin S., Mark A. Terry, Neda Shamie, Karen L. Hoar, and Daniel J. Friend. "Descemet-Stripping Automated Endothelial Keratoplasty." Cornea 27, no. 5 (June 2008): 514–20. http://dx.doi.org/10.1097/ico.0b013e3181611c50.

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6

Ide, Takeshi, Sonia H. Yoo, George D. Kymionis, James M. Goldman, Victor L. Perez, and Terrence P. OʼBrien. "Descemet-stripping Automated Endothelial Keratoplasty." Cornea 27, no. 7 (August 2008): 754–57. http://dx.doi.org/10.1097/ico.0b013e31816a6266.

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7

Gorovoy, Mark S. "Descemet-Stripping Automated Endothelial Keratoplasty." Cornea 25, no. 8 (September 2006): 886–89. http://dx.doi.org/10.1097/01.ico.0000214224.90743.01.

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8

Sharma, Namrata, PrafullaK Maharana, Shipra Singhi, Neelima Aron, and Mukesh Patil. "Descemet stripping automated endothelial keratoplasty." Indian Journal of Ophthalmology 65, no. 3 (2017): 198. http://dx.doi.org/10.4103/ijo.ijo_874_16.

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9

Tourtas, Theofilos, Kathrin Laaser, Bjoern O. Bachmann, Claus Cursiefen, and Friedrich E. Kruse. "Descemet Membrane Endothelial Keratoplasty Versus Descemet Stripping Automated Endothelial Keratoplasty." American Journal of Ophthalmology 153, no. 6 (June 2012): 1082–90. http://dx.doi.org/10.1016/j.ajo.2011.12.012.

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10

Dunker, Suryan L., Mor M. Dickman, Robert P. L. Wisse, Siamak Nobacht, Robert H. J. Wijdh, Marjolijn C. Bartels, Mei L. Tang, Frank J. H. M. van den Biggelaar, Pieter J. Kruit, and Rudy M. M. A. Nuijts. "Descemet Membrane Endothelial Keratoplasty versus Ultrathin Descemet Stripping Automated Endothelial Keratoplasty." Ophthalmology 127, no. 9 (September 2020): 1152–59. http://dx.doi.org/10.1016/j.ophtha.2020.02.029.

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11

Durrani, Asad F., Samuel C. Faith, and Vishal Jhanji. "Ultrathin Descemet stripping automated endothelial keratoplasty." Current Opinion in Ophthalmology 30, no. 4 (July 2019): 264–70. http://dx.doi.org/10.1097/icu.0000000000000575.

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12

Ide, Takeshi, Sonia H. Yoo, George D. Kymionis, Victor L. Perez, James M. Goldman, and Terrence P. OʼBrien. "Descemet-stripping Automated Endothelial Keratoplasty (DSAEK)." Cornea 27, no. 5 (June 2008): 562–64. http://dx.doi.org/10.1097/ico.0b013e318165841f.

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13

Woo, Jyh-Haur, Marcus Ang, Hla Myint Htoon, and Donald Tan. "Descemet Membrane Endothelial Keratoplasty Versus Descemet Stripping Automated Endothelial Keratoplasty and Penetrating Keratoplasty." American Journal of Ophthalmology 207 (November 2019): 288–303. http://dx.doi.org/10.1016/j.ajo.2019.06.012.

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14

Droutsas, Konstantinos, Myrsini Petrelli, Dimitrios Miltsakakis, Konstantinos Andreanos, Anastasia Karagianni, Apostolos Lazaridis, Chrysanthi Koutsandrea, and George Kymionis. "Visual Outcomes of Ultrathin-Descemet Stripping Endothelial Keratoplasty versus Descemet Stripping Endothelial Keratoplasty." Journal of Ophthalmology 2018 (November 1, 2018): 1–5. http://dx.doi.org/10.1155/2018/5924058.

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Purpose. To examine the impact of graft thickness (GT) on postoperative visual acuity and endothelial cell density after ultrathin-Descemet stripping automated endothelial keratoplasty (UT-DSAEK) versus conventional DSAEK. Methods. The medical records of all patients who underwent DSAEK at our institute during a 2-year period were reviewed. After excluding subjects with low visual potential, 34 eyes were divided into two groups based on the postoperative GT as measured with anterior segment optical coherence tomography (AS-OCT): an UT-DSAEK group (GT ≤ 100 μm, n=13 eyes) and a DSAEK group (GT > 100 μm, n=21 eyes). The groups were compared with regard to best-corrected visual acuity (BCVA), subjective refraction, central corneal thickness (CCT), GT, and endothelial cell density (ECD). Results. Preoperative BCVA (logMAR) was 1.035 ± 0.514 and 0.772 ± 0.428 for UT-DSAEK and DSAEK, respectively (P=0.072). At 6 months postoperatively, BCVA was 0.088 ± 0.150 following UT-DSAEK and 0.285 ± 0.158 following DSAEK (P=0.001). Conclusion. DSAEK grafts with a thickness under 100 μm offered better visual outcomes during the early postoperative period.

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15

Parikh, Purak C. "Review of Descemet Stripping Automated Endothelial Keratoplasty Versus Descemet Membrane Endothelial Keratoplasty." Advances in Ophthalmology and Optometry 1, no. 1 (August 2016): 21–29. http://dx.doi.org/10.1016/j.yaoo.2016.03.020.

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16

Mehta, Jodhbir Singh, Yu Qiang Soh, and Viridiana Kocaba. "Evolving Therapies for Fuchs Endothelial Dystrophy." European Ophthalmic Review 12, no. 1 (2018): 26. http://dx.doi.org/10.17925/eor.2018.12.1.26.

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Fuchs endothelial corneal dystrophy (FED) is one of the leading indications for corneal transplantation. Over the last two decades we have seen a significant shift in transplantation procedures for endothelial disease away from penetrating keratoplasty to small incision procedures such as Descemet stripping automated endothelial keratoplasty and Descemet membrane endothelial keratoplasty. More recently, even newer concepts have come to light to explore options of regenerative therapy for FED, e.g. Descemet stripping without endothelial keratoplasty, Descemet membrane transplantation and the use of adjuncts such as Rho kinase inhibitors. Furthermore, alternative strategies involving tissue engineering approaches with the use of cell therapy are also reaching early clinical trial stage. With more information on the underlying genetic abnormalities in FED, gene therapy may be a possible future treatment.

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17

Hsieh, Yi-Ching, Chun-Chi Chiang, and Yi-Yu Tsai. "Long-term observation of graft thickness and shape in Descemet stripping and automated endothelial keratoplasty." European Journal of Ophthalmology 30, no. 1 (January 24, 2019): 155–61. http://dx.doi.org/10.1177/1120672119826004.

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Purpose: To evaluate the thickness and shape of the posterior lamellar graft in Descemet stripping and automated endothelial keratoplasty after long-term observation. Methods: All patients who underwent Descemet stripping and automated endothelial keratoplasty including simple and triple Descemet stripping and automated endothelial keratoplasty between August 2009 and May 2014 were enrolled in this retrospective study. To assess postoperative thickness and shape of the Descemet stripping and automated endothelial keratoplasty graft, images of the graft taken at the center (C), mid-periphery at 4 mm optical zone (P1), and periphery at 6 mm optical zone (P2) at 1, 2, and 3 years postoperatively were obtained using anterior segment optical coherence tomography. Results: C:P1 was 0.96, 0.96, and 0.95 at 1, 2, and 3 years postoperatively, respectively. C:P2 was 0.85, 0.84, and 0.83 at 1, 2, and 3 years postoperatively, respectively. There was a greater thinning of the central graft thickness compared with the peripheral graft thickness. The shapes of the posterior lamellar graft were variable, such as concave, asymmetrical, planar, irregular, and convex meniscus shapes. The most common shape was asymmetrical shape at 1 year postoperatively and concave at 2 and 3 years postoperatively. The most common shape of the posterior lamellar grafts was asymmetrical shape (38.18%) at 1 year postoperatively, followed by concave (34.54%), planar (20.00%), irregular (5.45%), and convex (1.81%) shapes. The most common shape was concave shape (44.44% and 57.14% for 2 and 3 years postoperatively, respectively), followed by asymmetrical (27.77% and 17.85%, respectively), planar (16.66% and 17.85%, respectively), and irregular (11.11% and 7.14%, respectively) shapes. Conclusion: In our study, concave meniscus was not the only observed shape of the graft. The shape and thickness of the graft did not stabilize even 3 years postoperatively in some patients. These findings should be taken into consideration in a combination of Descemet stripping and automated endothelial keratoplasty and cataract surgery.

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18

Gorovoy, Mark S., David M. Meisler, and William J. Dupps. "Late Repeat Descemet-Stripping Automated Endothelial Keratoplasty." Cornea 27, no. 2 (February 2008): 238–40. http://dx.doi.org/10.1097/ico.0b013e31815b82e0.

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19

Gorovoy, Mark, David Meisler, and William Dupps. "Late Repeat Descemet Stripping Automated Endothelial Keratoplasty." Cornea 27, no. 10 (December 2008): 1216. http://dx.doi.org/10.1097/ico.0b013e31818147ed.

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20

Mukherjee, Achyut, George Voyatzis, and Madhavan S. Rajan. "Reply to “Descemet Stripping Automated Endothelial Keratoplasty." Cornea 32, no. 1 (January 2013): 108–9. http://dx.doi.org/10.1097/ico.0b013e318263d08e.

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21

Vajpayee, Rasik B., Tushar Agarwal, Vishal Jhanji, and Namrata Sharma. "Modification in Descemet-Stripping Automated Endothelial Keratoplasty." Cornea 25, no. 9 (October 2006): 1060–62. http://dx.doi.org/10.1097/01.ico.0000225707.70135.34.

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22

Toshida, Hiroshi, Toshihiko Ohta, Akira Murakami, Akira Kobayashi, and Kazuhisa Sugiyama. "Descemet stripping automated endothelial keratoplasty for microcornea." Japanese Journal of Ophthalmology 56, no. 5 (July 7, 2012): 436–40. http://dx.doi.org/10.1007/s10384-012-0163-2.

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23

Bänninger, Philipp B., and Claus Konschak. "Die posteriore lamelläre Keratoplastik zur Behandlung von Endothelerkrankungen." Im OP 08, no. 02 (February 20, 2018): 54–58. http://dx.doi.org/10.1055/s-0043-124023.

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Zusammenfassung OP-Ablauf Die posteriore lamelläre Keratoplastik stellt ein verlässliches Verfahren zur schnellen visuellen Rehabilitation von Patienten mit Erkrankungen des Hornhautendothels dar. Unsere Autoren von der Augenklinik des Luzerner Kantonsspitals stellen die Technik der posterioren lamellären Keratoplastik mittels Descemetstripping und Mikrokeratom (DSAEK: Descemet Stripping Automated Endothelial Keratoplasty) vor.

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24

Sahay, Pranita, Deepali Singhal, Prafulla K. Maharana, and Jeewan S. Titiyal. "Is Nanothin Descemet Stripping Automated Endothelial Keratoplasty Comparable to Descemet Membrane Endothelial Keratoplasty?" Cornea 37, no. 12 (December 2018): e56. http://dx.doi.org/10.1097/ico.0000000000001768.

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25

Zhu, Leru, Yi Zha, Jianqiu Cai, and Yanling Zhang. "Descemet stripping automated endothelial keratoplasty versus descemet membrane endothelial keratoplasty: a meta-analysis." International Ophthalmology 38, no. 2 (April 17, 2017): 897–905. http://dx.doi.org/10.1007/s10792-017-0533-3.

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26

Titiyal, JeewanS, Manpreet Kaur, Meghal Gagrani, Farin Shaikh, Tushar Agarwal, Rajesh Sinha, and Namrata Sharma. "Repeat keratoplasty in failed Descemet stripping automated endothelial keratoplasty." Indian Journal of Ophthalmology 67, no. 10 (2019): 1586. http://dx.doi.org/10.4103/ijo.ijo_1729_18.

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27

Omoto, Takashi, Toshihiro Sakisaka, Tetsuya Toyono, Junko Yoshida, Rika Shirakawa, Takashi Miyai, Satoru Yamagami, and Tomohiko Usui. "Descemet Stripping Automated Endothelial Keratoplasty for Failed Penetrating Keratoplasty." Cornea 37, no. 4 (April 2018): 462–65. http://dx.doi.org/10.1097/ico.0000000000001531.

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28

Jangi, Anisha A., David C. Ritterband, Elaine I. Wu, Veeral V. Mehta, Richard S. Koplin, and John A. Seedor. "Descemet Stripping Automated Endothelial Keratoplasty After Failed Penetrating Keratoplasty." Cornea 31, no. 10 (October 2012): 1148–53. http://dx.doi.org/10.1097/ico.0b013e31823f78b3.

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29

Mitry, Danny, Maninder Bhogal, Amit K. Patel, Bryan S. Lee, Shu Ming Chai, Marianne O. Price, Francis W. Price, et al. "Descemet Stripping Automated Endothelial Keratoplasty After Failed Penetrating Keratoplasty." JAMA Ophthalmology 132, no. 6 (June 1, 2014): 742. http://dx.doi.org/10.1001/jamaophthalmol.2014.352.

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30

Guerra, Frederico P., Arundhati Anshu, Marianne O. Price, and Francis W. Price. "Endothelial Keratoplasty: Fellow Eyes Comparison of Descemet Stripping Automated Endothelial Keratoplasty and Descemet Membrane Endothelial Keratoplasty." Cornea 30, no. 12 (December 2011): 1382–86. http://dx.doi.org/10.1097/ico.0b013e31821ddd25.

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31

Yamazaki, Risa, Ryohei Nejima, Yoshiyuki Ichihashi, Kazunori Miyata, Kazuo Tsubota, and Shigeto Shimmura. "Descemet stripping and automated endothelial keratoplasty (DSAEK) versus non-Descemet stripping and automated endothelial keratoplasty (nDSAEK) for bullous keratopathy." Japanese Journal of Ophthalmology 64, no. 6 (September 3, 2020): 585–90. http://dx.doi.org/10.1007/s10384-020-00767-8.

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32

Gross, N. J., D. Böhringer, P. Maier, and T. Reinhard. "Perforierende Keratoplastik vs. „Descemet stripping automated endothelial keratoplasty“ im Partnerauge." Der Ophthalmologe 112, no. 10 (May 6, 2015): 848–53. http://dx.doi.org/10.1007/s00347-015-0010-1.

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33

Mehta, J. S., R. Poh, R. W. Beuerman, and D. T. H. Tan. "Late Endothelial Failure After Descemet Stripping Automated Endothelial Keratoplasty." Cornea 27, no. 10 (December 2008): 1215–16. http://dx.doi.org/10.1097/ico.0b013e31818147d5.

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34

Mimouni, Michael, Nir Sorkin, Jacqueline Slomovic, Eli Kisilevsky, Zale Mednick, Eyal Cohen, Tanya Trinh, et al. "Descemet Membrane Endothelial Keratoplasty versus Descemet Stripping Automated Endothelial Keratoplasty in Complicated Vitrectomized Eyes." Current Eye Research 46, no. 9 (March 4, 2021): 1283–90. http://dx.doi.org/10.1080/02713683.2021.1892150.

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35

Maier, A.-KB, E. Gundlach, J. Gonnermann, M. K. J. Klamann, E. Bertelmann, P. W. Rieck, A. M. Joussen, and N. Torun. "Retrospective contralateral study comparing Descemet membrane endothelial keratoplasty with Descemet stripping automated endothelial keratoplasty." Eye 29, no. 3 (November 21, 2014): 327–32. http://dx.doi.org/10.1038/eye.2014.280.

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36

Busin, Massimo, and Angeli Christy Yu. "The Ongoing Debate: Descemet Membrane Endothelial Keratoplasty Versus Ultrathin Descemet Stripping Automated Endothelial Keratoplasty." Ophthalmology 127, no. 9 (September 2020): 1160–61. http://dx.doi.org/10.1016/j.ophtha.2020.03.023.

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37

Goldich, Yakov, Mahmood Showail, Noa Avni-Zauberman, Mauricio Perez, Randall Ulate, Uri Elbaz, and David S. Rootman. "Contralateral Eye Comparison of Descemet Membrane Endothelial Keratoplasty and Descemet Stripping Automated Endothelial Keratoplasty." American Journal of Ophthalmology 159, no. 1 (January 2015): 155–59. http://dx.doi.org/10.1016/j.ajo.2014.10.009.

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38

Singh, Abhimanyu, Mehran Zarei-Ghanavati, Venkata Avadhanam, and Christopher Liu. "Systematic Review and Meta-Analysis of Clinical Outcomes of Descemet Membrane Endothelial Keratoplasty Versus Descemet Stripping Endothelial Keratoplasty/Descemet Stripping Automated Endothelial Keratoplasty." Cornea 36, no. 11 (November 2017): 1437–43. http://dx.doi.org/10.1097/ico.0000000000001320.

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39

Li, Chendi, Wenyu Wu, Gege Xiao, Vishal Jhanji, Jing Hong, and Yun Feng. "Descemet Stripping Automated Endothelial Keratoplasty in Thick Corneas." Journal of Clinical Medicine 11, no. 19 (September 23, 2022): 5601. http://dx.doi.org/10.3390/jcm11195601.

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Purpose: To evaluate the outcomes of Descemet’s Stripping Automated Endothelial Keratoplasty (DSAEK) in corneas > 820 microns in thickness. Methods: This retrospective study included 30 eyes of 30 patients who underwent DSAEK. Endothelial cell destiny (ECD) and corneal thickness were recorded before surgery and at 1 and 12 months postoperatively. Patients were divided into two groups (≤ 820 microns and > 820 microns) based on median preoperative corneal thickness. Linear regression analyses were used to investigate the correlations between ECD and preoperative corneal thickness. Results: Recipient corneal thickness (RCT) and postoperative central cornea thickness had a statistically significant difference 1 month after surgery (p = 0.03, p = 0.08, respectively). BCVA and ECD did not have a statistical difference in the two groups at 1 month and 12 months after DSAEK. Conclusions: BCVA, ECD and corneal thickness were similar at 12 months after DSAEK in thick corneas. DSAEK is a viable surgical option in thick corneas.

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40

Mallias, Ioannis, Panagiota Mylova, and Anastasia Tassiopoulou. "Fungal keratitis after descemet stripping automated endothelial keratoplasty." Ophthalmology Journal 2, no. 4 (March 30, 2018): 105–9. http://dx.doi.org/10.5603/oj.2017.0022.

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41

Sharma, Namrata, Prakash Chand Agarwal, Chandra Shekhar Kumar, Rashim Mannan, and Jeewan S. Titiyal. "Microbial Keratitis After Descemet Stripping Automated Endothelial Keratoplasty." Eye & Contact Lens: Science & Clinical Practice 37, no. 5 (September 2011): 320–22. http://dx.doi.org/10.1097/icl.0b013e31820e7144.

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42

Nahum, Yoav, Cataldo Russo, Silvana Madi, and Massimo Busin. "Interface Infection After Descemet Stripping Automated Endothelial Keratoplasty." Cornea 33, no. 9 (September 2014): 893–98. http://dx.doi.org/10.1097/ico.0000000000000205.

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43

Khor, Wei-Boon, Kelvin Y. Teo, Jodhbir S. Mehta, and Donald T.-H. Tan. "Descemet Stripping Automated Endothelial Keratoplasty in Complex Eyes." Cornea 32, no. 8 (August 2013): 1063–68. http://dx.doi.org/10.1097/ico.0b013e31828321f8.

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44

Marta, Ana, Paula Costa, Virgínia Lopes, Miguel Mesquita Neves, Miguel Gomes, and Luís Oliveira. "Exophiala Keratitis following Descemet Stripping Automated Endothelial Keratoplasty." Case Reports in Ophthalmological Medicine 2020 (October 29, 2020): 1–3. http://dx.doi.org/10.1155/2020/8872465.

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Purpose. To report a case with Exophiala spp. keratitis in a Portuguese patient. Methods. A case report with deep corneal brown-pigmented infiltrates that developed 2 months after a Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) for pseudophakic bullous keratopathy. Results. Diagnosis was established by positive direct examination and cultures from the surgically obtained corneal button. Slit-lamp images and anterior segment optical coherence tomography (AS-OCT) scans were obtained. Conclusion. This is the first described case of fungal keratitis caused by Exophiala spp. in Portugal and, to our knowledge, the first case following DSAEK in the literature.

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45

Prasher, Pawan, Orkun Muftuoglu, M. L. Hsiao, R. W. Bowman, R. N. Hogan, and V. Vinod Mootha. "Epithelial Downgrowth After Descemet Stripping Automated Endothelial Keratoplasty." Cornea 28, no. 6 (July 2009): 708–11. http://dx.doi.org/10.1097/ico.0b013e318190d675.

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46

Gorovoy, Mark S., and Arlene Ratanasit. "Epithelial Downgrowth After Descemet Stripping Automated Endothelial Keratoplasty." Cornea 29, no. 10 (October 2010): 1192–94. http://dx.doi.org/10.1097/ico.0b013e3181d25fe8.

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47

Schmitt, Artur J., Michael R. Feilmeier, Fernanda V. Piccoli, Takeshi Ide, and Sonia H. Yoo. "Interface Blood After Descemet Stripping Automated Endothelial Keratoplasty." Cornea 30, no. 7 (July 2011): 815–17. http://dx.doi.org/10.1097/ico.0b013e3182031fec.

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48

Hong, Ying, Jing Hong, Yong-gen Xu, and Xin Wang. "Comment on Phakic Descemet Stripping Automated Endothelial Keratoplasty." Cornea 32, no. 2 (February 2013): 217. http://dx.doi.org/10.1097/ico.0b013e31825e83ab.

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49

Price, Francis W. "Precut Tissue For Descemet Stripping Automated Endothelial Keratoplasty." Cornea 27, no. 6 (July 2008): 630–31. http://dx.doi.org/10.1097/01.ico.0000611360.43429.5b.

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50

Gorovoy, Mark S. "Precut Tissue For Descemet Stripping Automated Endothelial Keratoplasty." Cornea 27, no. 6 (July 2008): 632–33. http://dx.doi.org/10.1097/01.ico.0000611364.51052.79.

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