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Journal articles on the topic 'Dermo-Cosmetic'

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Author: Grafiati

Published: 22 June 2023

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1

Popescu, Viorica, Alina Soceanu, and Simona Dobrinas. "The quality control of some dermo-cosmetic products." Analele Universitatii "Ovidius" Constanta - Seria Chimie 25, no. 2 (December 1, 2014): 85–90. http://dx.doi.org/10.2478/auoc-2014-0016.

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Abstract This paper refers to the quality analysis of three dermo-cosmetic products: two face creams and a biphasic solution used for skin cleaning: a treatment cream for acne complexion, an anti-irritating soothing cream and a matifying purifying lotion. The following characteristics have been investigated: aspect, smell, colour, solubility, type of emulsion, stability test at certain temperatures (4°C and 40°C), pH, melting point, water, volatile substances and total fats contents, acidity, ester index, saponification index, iodine index, peroxide index, microbic carriage, metal traces (determined by ICP-MS method). All analysed dermo-cosmetic products have appropriate physico-chemical characteristics. The analyses made for determining the microbial charge have proven that the three dermo-cosmetic products do not contain any aerobic pathogen germens or micromicetes, Staphylococcus aureus and Escherichia Coli. The ICP-MS analysis has proven that the dermocosmetic products do not contain traces of Hg and Pb.

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2

Diehl, C. "Dermo-cosmetic management of the periorbital complex." Ukrainian Journal of Dermatology, Venerology, Cosmetology, no. 3 (September 18, 2020): 85–92. http://dx.doi.org/10.30978/ujdvk2020-3-85.

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3

Potpara, Zorica, Snezana Pantovic, Natasa Duborija-Kovacevic, Vanja Tadic, Tanja Vojinovic, and Nada Marstijepovic. "The Properties of the Ulcinj Peloid make it Unique Biochemical Laboratory Required for the Treatment of Problematic Skin and Health Care." Natural Product Communications 12, no. 6 (June 2017): 1934578X1701200. http://dx.doi.org/10.1177/1934578x1701200620.

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The aim of this study was to investigate the physicochemical properties of peloid, its mineralogical composition and its antimicrobial activity, including the presence of algae, with the aim of considering its dermo-cosmetic application, such as anti-skin aging and treatment. Physicochemical analysis showed that peloid from Ulcinj coast, contains minerals, necessary for smooth performance of skin functions, as well as, the whole body. A studied peloid sample showed significant antimicrobial activity of Candida albicans strain, and the presence of algae of Bacillariophyta division, known to have a beneficial effect on skin health. Results of examination of peloid from Ulcinj locality, recommended it as a high quality natural substance applicative in dermo-cosmetic preparations for treatment of problematic skin.

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4

Argenziano, Rita, Maria Laura Alfieri, Noemi Gallucci, Gerardino D’Errico, Lucia Panzella, and Alessandra Napolitano. "A Model Eumelanin from 5,6-Dihydroxyindole-2-Carboxybutanamide Combining Remarkable Antioxidant and Photoprotective Properties with a Favourable Solubility Profile for Dermo-Cosmetic Applications." International Journal of Molecular Sciences 24, no. 4 (February 20, 2023): 4241. http://dx.doi.org/10.3390/ijms24044241.

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The search for new synthetic melanin-related pigments that maintain the antioxidant and photoprotective properties of naturally occurring dark eumelanins, while overcoming their unfavorable solubility, and molecular heterogeneity is presently a very active issue for dermo-cosmetic purposes. In this work, we explored the potential of a melanin obtained from the carboxybutanamide of a major eumelanin biosynthetic precursor, 5,6-dihydroxyindole-2-carboxylic acid (DHICA), by aerobic oxidation under slightly alkaline conditions. Analysis of the pigment by EPR, ATR-FTIR and MALDI MS indicated a substantial structural similarity to DHICA melanin, while investigation of the early intermediates confirmed unchanged regiochemistry of the oxidative coupling. The pigment exhibited a UVA–visible absorption even more intense than that of DHICA melanin, and a noticeable solubility in polar solvents of dermo-cosmetic relevance. The hydrogen- and/or electron-donor ability, and the iron (III) reducing power as determined by conventional assays provided evidence for marked antioxidant properties not merely ascribable to the more favorable solubility profile, while the inhibitory action of the radical- or photosensitized solar light-induced lipid peroxidation was more marked compared to that of DHICA melanin. Overall, these results hint at this melanin, which remarkable properties are, in part, due to the electronic effects of the carboxyamide functionality as a promising functional ingredient for dermo-cosmetic formulations.

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5

Kirilov, P., S. Rum, E. Gilbert, L. Roussel, D. Salmon, R. Abdayem, C. Serre, et al. "Aqueous dispersions of organogel nanoparticles - potential systems for cosmetic and dermo-cosmetic applications." International Journal of Cosmetic Science 36, no. 4 (May 16, 2014): 336–46. http://dx.doi.org/10.1111/ics.12131.

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6

Kalasariya, Haresh S., and Leonel Pereira. "Dermo-Cosmetic Benefits of Marine Macroalgae-Derived Phenolic Compounds." Applied Sciences 12, no. 23 (November 23, 2022): 11954. http://dx.doi.org/10.3390/app122311954.

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Marine macroalgae have an interesting profile of bioactive compounds and have gained tremendous attention in cosmeceuticals with negligible toxicity effects (cytotoxicity, reproductive toxicity, genotoxicity, mutagenicity, carcinogenicity, etc.) on humans and exhibit strong benefits for the skin. Among the diversified compounds, phenolic compounds are the group of phytochemicals found in high amounts with great structural diversity. Phlorotannin is the most studied polyphenol compound in brown algae, but besides there are some other phenolic compounds observed and studied in macroalgae such as terpenoids, bromophenols, mycosporine amino acids (MAAs), and flavonoids. These compounds are already characterized and studied for their full range of cosmeceutical benefits such as skin whitening, moisturizing, photoprotection, antiaging, antiwrinkle, anti-melanogenic, and antioxidant activities as well as in the treatment of pruritus (caused by acne, eczema, dermatitis, hives, psoriasis), photoaging, and skin pigmentation disorders (hypopigmentation due to the absence of melanocytes and hyperpigmentation caused by skin irritation or metabolic disorders). This review study mainly focuses on marine algae-derived phenolic compounds and their extraction, characterization, and skin cosmetic benefits described in the literature. The present study aims to provide a detailed insight into the phenolic compounds in marine algae.

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7

Taieb, C., N. Perez-Cullell, and S. Branchoux. "PSS30 Cosmeceutiqol: A Dermo-Cosmetic Quality-of-Life Assessment Tool." Value in Health 15, no. 7 (November 2012): A574. http://dx.doi.org/10.1016/j.jval.2012.08.2077.

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8

Axiotis, Evangelos, Apostolis Angelis, Lemonia Antoniadi, Eleftherios A. Petrakis, and Leandros A. Skaltsounis. "Phytochemical Analysis and Dermo-Cosmetic Evaluation of Cymbidium sp. (Orchidaceae) Cultivation By-Products." Antioxidants 11, no. 1 (December 31, 2021): 101. http://dx.doi.org/10.3390/antiox11010101.

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Cymbidium is one of the most popular genera in Orchidaceae family, commercialized either as loose flowers or as potted plants in floriculture worldwide. The non-marketable parts are typically discarded (e.g., unsuitable flowers, leaves, pseudobulbs, roots), generating an enormous quantity of unutilized biomass. The above by-products were studied through phytochemical analysis and investigated for their dermo-cosmetic potential. The initial antioxidant, anti-tyrosinase, anti-elastase, and anti-collagenase assays of the total extracts indicated that the pseudobulb and root ethyl acetate extracts were the most potent. Those extracts were then submitted to chromatographic separation leading to the isolation of 16 secondary metabolites (four phenanthrenes, three 1,4-phenanthrenquinones, three dibenzyls, two phenolic acid derivatives, two sterols, one dehydrodiconiferyl alcohol derivative, and one simple phenolic compound), including 6-hydroxy-5,7-dimethoxy-1,4-phenanthrenequinone (cymbisamoquinone), which was identified as a new natural product. In parallel, 48 metabolites were identified by UPLC-HRMS analysis of the extracts. The biological evaluation of the isolated compounds revealed that gigantol and tristin present important anti-tyrosinase activity, while bulbophyllanthrin, 3-hydroxy-2,4,7-trimethoxy-phenanthrene, marylaurencinol A, 5-hydroxy-2-methoxy-1,4-phenanthrenequinone, and ephemeranthroquinone B show dose-dependent anti-collagenase activity. In contrast to isolated metabolites, which may act selectively on specific enzymes, the initial total extracts exhibited inhibitory activity against tyrosinase, elastase, and collagenase enzymes, thus showing better prospects for use in dermo-cosmetic formulations.

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9

Hubert, Jane, Apostolis Angelis, Nektarios Aligiannis, Michalea Rosalia, Amin Abedini, Ali Bakiri, Romain Reynaud, et al. "In Vitro Dermo-Cosmetic Evaluation of Bark Extracts from Common Temperate Trees." Planta Medica 82, no. 15 (June 28, 2016): 1351–58. http://dx.doi.org/10.1055/s-0042-110180.

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10

Bousquet, Marie-Pierre, Ren�-Marc Willemot, Pierre Monsan, and Emmanuel Boures. "Enzymatic synthesis of unsaturated fatty acid glucoside esters for dermo-cosmetic applications." Biotechnology and Bioengineering 63, no. 6 (June 20, 1999): 730–36. http://dx.doi.org/10.1002/(sici)1097-0290(19990620)63:6<730::aid-bit11>3.0.co;2-j.

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11

Michailidis, Dimitris, Apostolis Angelis, Panagiota Efstathia Nikolaou, Sofia Mitakou, and Alexios Léandros Skaltsounis. "Exploitation of Vitis vinifera, Foeniculum vulgare, Cannabis sativa and Punica granatum By-Product Seeds as Dermo-Cosmetic Agents." Molecules 26, no. 3 (January 31, 2021): 731. http://dx.doi.org/10.3390/molecules26030731.

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In the current study, by-product seed pastes (VSPs) from Vitis vinifera, Foeniculum vulgare, Cannabis sativa and Punica granatum, generated during the oil production process, were investigated for their potential exploitation as dermo-cosmetic agent. The extraction pipeline of all the raw materials was developed with emphasis on green methodologies and employed on laboratory scale based on industry-adopted techniques. Two different protocols were applied, Supercritical Fluid Extraction (SFE) and Ultrasound Assisted Extraction (UAE); the by-product pastes were defatted with supercritical CO2 and n-Hexane, respectively. Then, two SFE extracts (CO2 with 10% and 20% of ethanol as co-solvent) and two UAE extracts (with ethanol and ethanol/water 1:1 v/v) were obtained from each raw material. The providing yield range was between 2.6 to 76.3 mg/g raw material. The extracts were analyzed with High-Performance Liquid Chromatography coupled with Diode Array Detector (HPLC-DAD) and Liquid Chromatography coupled with High-Resolution Mass Spectrometer (LC-HRMS), and the major compounds, were identified. All the extracts were evaluated for their antioxidant and inhibition activity against collagenase, elastase and tyrosinase enzymes. Grapevine by-product extracts found rich in proanthocyanidins and presented the higher inhibition activity. A holistic green experimental methodology is proposed for the obtainment of extracts from significant medicinal plants by-products that provides us with promising results concerning dermo-cosmetic properties, especially for grape seeds extracts.

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12

Gueniche, Audrey, Olivier Perin, Amina Bouslimani, Leslie Landemaine, Namita Misra, Sylvie Cupferman, Luc Aguilar, Cécile Clavaud, Tarun Chopra, and Ahmad Khodr. "Advances in Microbiome-Derived Solutions and Methodologies Are Founding a New Era in Skin Health and Care." Pathogens 11, no. 2 (January 20, 2022): 121. http://dx.doi.org/10.3390/pathogens11020121.

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The microbiome, as a community of microorganisms and their structural elements, genomes, metabolites/signal molecules, has been shown to play an important role in human health, with significant beneficial applications for gut health. Skin microbiome has emerged as a new field with high potential to develop disruptive solutions to manage skin health and disease. Despite an incomplete toolbox for skin microbiome analyses, much progress has been made towards functional dissection of microbiomes and host-microbiome interactions. A standardized and robust investigation of the skin microbiome is necessary to provide accurate microbial information and set the base for a successful translation of innovations in the dermo-cosmetic field. This review provides an overview of how the landscape of skin microbiome research has evolved from method development (multi-omics/data-based analytical approaches) to the discovery and development of novel microbiome-derived ingredients. Moreover, it provides a summary of the latest findings on interactions between the microbiomes (gut and skin) and skin health/disease. Solutions derived from these two paths are used to develop novel microbiome-based ingredients or solutions acting on skin homeostasis are proposed. The most promising skin and gut-derived microbiome interventional strategies are presented, along with regulatory, safety, industrial, and technical challenges related to a successful translation of these microbiome-based concepts/technologies in the dermo-cosmetic industry.

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13

Moccia, Federica, Davide Liberti, Samuele Giovando, Carla Caddeo, Daria Maria Monti, Lucia Panzella, and Alessandra Napolitano. "Chestnut Wood Mud as a Source of Ellagic Acid for Dermo-Cosmetic Applications." Antioxidants 11, no. 9 (August 28, 2022): 1681. http://dx.doi.org/10.3390/antiox11091681.

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Ellagic acid (EA) has long been recognized as a very active antioxidant, anti-inflammatory, and antimicrobial agent. However, its low bioavailability has often hampered its applications in health-related fields. Here, we report a phospholipid vesicle-based controlled release system for EA, involving the exploitation of chestnut wood mud (CWM), an industrial by-product from chestnut tannin production, as a largely available and low-cost source of this compound. Two kinds of CWM with different particle size distributions, indicated as CWM-A and CWM-B (<100 and 32 µm, respectively), containing 5 ± 1% w/w EA, were incorporated into transfersomes. The latter were small in size (~100 nm), homogeneously dispersed, and negatively charged. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing/antioxidant power (FRAP) assays indicated up to three-fold improvement in the antioxidant properties of CWM upon incorporation into transfersomes. The kinetics of EA released under simulated physiological conditions were evaluated by UV-Vis spectroscopy and HPLC analysis. The best results were obtained with CWM-B (100% of EA gradually released after 37 days at pH 7.4). A stepwise increase in the antioxidant properties of the released material was also observed. Cell-based experiments confirmed the efficacy of CWM-B transfersomes as antioxidant agents in contrasting photodamage.

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14

Taieb, Charles, Nora Rahhali, Valentin Moingeon, Nuria Perez-Cullell, and Vincent Sibaud. "CosmeceutiQoL: A tool for assessing dermo-cosmetic products’ impact on quality of life." Journal of Cosmetic and Laser Therapy 14, no. 1 (October 27, 2011): 18–23. http://dx.doi.org/10.3109/14764172.2011.634420.

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15

Bousquet, Marie-Pierre, René-Marc Willemot, Pierre Monsan, and Emmanuel Boures. "Lipase-catalyzed α-butylglucoside lactate synthesis in organic solvent for dermo-cosmetic application." Journal of Biotechnology 68, no. 1 (February 1999): 61–69. http://dx.doi.org/10.1016/s0168-1656(98)00191-6.

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16

Baldisserotto, Anna, Gemma Malisardi, Emanuela Scalambra, Elisa Andreotti, Carlo Romagnoli, Chiara Vicentini, Stefano Manfredini, and Silvia Vertuani. "Synthesis, Antioxidant and Antimicrobial Activity of a New Phloridzin Derivative for Dermo-Cosmetic Applications." Molecules 17, no. 11 (November 7, 2012): 13275–89. http://dx.doi.org/10.3390/molecules171113275.

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17

Ribet, Virginie, Vincenzo Nobile, and Ana Beatris Rossi. "In situ antioxidant activity of a dermo‐cosmetic product: A randomized controlled clinical study." Experimental Dermatology 28, no. 11 (September 30, 2019): 1219–26. http://dx.doi.org/10.1111/exd.14005.

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18

Quinty, Vanille, Cyril Colas, Rouba Nasreddine, Reine Nehmé, Christine Piot, Micheline Draye, Emilie Destandau, David Da Silva, and Gregory Chatel. "Screening and Evaluation of Dermo-Cosmetic Activities of the Invasive Plant Species Polygonum cuspidatum." Plants 12, no. 1 (December 23, 2022): 83. http://dx.doi.org/10.3390/plants12010083.

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Polygonum cuspidatum (P. cuspidatum) is among the world’s most problematic invasive plant species with negative ecological, socio-economic and security consequences. Management operations in areas invaded systematically generate a large quantity of plant waste, most often without outlets. Using this plant material could constitute a new alternative treatment for sustainable management. P. cuspidatum is well known to have numerous biological properties, containing notably stilbenes, quinones, flavonoids and phenolic acids. The present work proposes a reliable strategy using powerful techniques for the screening and the evaluation of the dermo-cosmetic potential of its aerial parts (AP) and root parts (RP). To the best of our knowledge, only antioxidant and anti-tyrosinase activities were previously evaluated on P. cuspidatum among the targets studied (superoxide dismutase, hyaluronidase, elastase, collagenase and tyrosinase). The results revealed strong antioxidant and anti-collagenase activities, moderate anti-hyaluronidase activity, while weak anti-elastase and anti-tyrosinase activities were observed for ethanolic extracts. Different standards selected and screened on the same targets made it possible to correlate the observed residual activities of produced extracts of P. cuspidatum from Savoie Mont Blanc and their chemical compositions. A structure-activity study was thus conducted on main molecular families, widely represented in the genus Polygonum.

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19

Liberti, Davide, Maria Laura Alfieri, Daria Maria Monti, Lucia Panzella, and Alessandra Napolitano. "A Melanin-Related Phenolic Polymer with Potent Photoprotective and Antioxidant Activities for Dermo-Cosmetic Applications." Antioxidants 9, no. 4 (March 25, 2020): 270. http://dx.doi.org/10.3390/antiox9040270.

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Eumelanins, the dark variant of skin pigments, are endowed with a remarkable antioxidant activity and well-recognized photoprotective properties that have been ascribed to pigment components derived from the biosynthetic precursor 5,6-dihydroxyindole-2-carboxylic acid (DHICA). Herein, we report the protective effect of a polymer obtained starting from the methyl ester of DHICA (MeDHICA-melanin) against Ultraviolet A (UVA)-induced oxidative stress in immortalized human keratinocytes (HaCaT). MeDHICA-melanin was prepared by aerial oxidation of MeDHICA. At concentrations as low as 10 µg/mL, MeDHICA-melanin prevented reactive oxygen species accumulation and partially reduced glutathione oxidation in UVA-irradiated keratinocytes. Western blot experiments revealed that the polymer is able to induce the translocation of nuclear factor erythroid 2–related factor 2 (Nrf-2) to the nucleus with the activation of the transcription of antioxidant enzymes, such as heme-oxygenase 1. Spectrophotometric and HPLC analysis of cell lysate allowed to conclude that a significant fraction (ca. 7%), consisting mainly of the 4,4′-dimer of MeDHICA (ca. 2 μM), was internalized in the cells. Overall these data point to the potential use of MeDHICA-melanin as an antioxidant for the treatment of skin damage, photoaging and skin cancers.

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20

Vertuani, Silvia, Erika Beghelli, Emanuela Scalambra, Gemma Malisardi, Stefano Copetti, Roberto Dal Toso, Anna Baldisserotto, and Stefano Manfredini. "Activity and Stability Studies of Verbascoside, a Novel Antioxidant, in Dermo-Cosmetic and Pharmaceutical Topical Formulations." Molecules 16, no. 8 (August 18, 2011): 7068–80. http://dx.doi.org/10.3390/molecules16087068.

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21

Catic, Tarik, Belma Pehlivanovic, Nejla Pljakic, and Amina Balicevac. "The Moisturizing Efficacy of a Dermo-Cosmetic Product (cls02021) Versus in a 6-week Application Period." Medical Archives 76, no. 2 (2022): 108. http://dx.doi.org/10.5455/medarh.2022.76.108-114.

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22

Ribet, Virginie, Laure Albinet Claudin, Elsa Brinio, Amélie Berthier, Violaine Millet, Clémence Halbeher, Laure Sauvaire, et al. "Surveillance of dermo-cosmetic products: a global cosmetovigilance system to optimise product development and consumer safety." European Journal of Dermatology 31, no. 4 (August 2021): 463–69. http://dx.doi.org/10.1684/ejd.2021.4101.

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23

Hubert, J., A. Angelis, N. Aligiannis, M. Rosalia, A. Abedini, A. Bakiri, R. Reynaud, et al. "Potential dermo-cosmetic use of barks from common deciduous and coniferous trees growing in temperate areas." Planta Medica 81, S 01 (December 14, 2016): S1—S381. http://dx.doi.org/10.1055/s-0036-1596430.

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24

Dissette, Valeria, Carlo Bignozzi, Giuseppe Valacchi, Alessandra Pecorelli, Stefano Manfredini, and Silvia Vertuani. "Evaluation of the Transepidermal Penetration of a Carnosine Complex in Gel Formulation by 3D Skin Models." Cosmetics 5, no. 4 (November 14, 2018): 67. http://dx.doi.org/10.3390/cosmetics5040067.

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Carnosine has several physiological roles, from intracellular pH buffering to antioxidant activities, which all depend on bioavailability. This study was conducted in a human skin 3D model and focuses on the effects of the topical delivery of carnosine, from a dermo-cosmetic gel, through the stratum corneum in the presence of a magnesium ion as a complexing agent. To evaluate possible enhancement for small peptide delivery to the skin from simple cosmetic formulations, we discovered that complexation was able to improve the delivery of carnosine into human skin 3D models by application in gel formulation. The concentrations of carnosine released in the underlying media and those that remained in the reconstructed human epidermis (RHE) tissues after 24 and 48 h exposure were measured. Moreover, the influence of magnesium ions was also evaluated comparing the same formulation with and without the salt. The results obtained in this study support hypothesis that magnesium can influence the delivery of small peptides and that the gel formulation based on the carnosine-magnesium complex allows for superior delivery of carnosine in the lower skin layer at a concentration up to 60% more than carnosine alone.

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25

Bino, Alessia, Chiara Vicentini, Silvia Vertuani, Ilaria Lampronti, Roberto Gambari, Elisa Durini, Stefano Manfredini, and Anna Baldisserotto. "Novel Lipidized Derivatives of the Bioflavonoid Hesperidin: Dermatological, Cosmetic and Chemopreventive Applications." Cosmetics 5, no. 4 (December 15, 2018): 72. http://dx.doi.org/10.3390/cosmetics5040072.

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Hesperidin is one of the most important natural flavonoids, known for its antioxidant, anti-inflammatory, anti-mutagenic, and anti-hypertensive properties. Despite its various biological activities, hesperidin is rarely used in the dermo-cosmetic field because of its poor solubility in both water and oil phases that makes difficult formulation, distribution and bioavailability through the skin layers. Moreover, hesperidin is still underestimated in skin care products, and literature data on its stability into a topical formulation are not yet available. In this paper we report the synthesis of five different derivatives of hesperidin and their evaluation in terms of antioxidant, antifungal, antiproliferative, and apoptotic effects on human leukemic K562 cells. Preliminary antiproliferative effects were considered since hyper-proliferation is involved in several cutaneous problems particularly in the case of photo-exposition and environmental pollution. Esp4 and Esp5 were found to be more active in inhibiting K562 cell growth than parent hesperidin. Esp3 exhibited different biological properties, i.e., antioxidant activity in the absence of antiproliferative effects.

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Paganelli, Alessia, Alessandra Pisciotta, Giulia Bertani, Rosanna Di Tinco, Nadia Tagliaferri, Giulia Orlandi, Paola Azzoni, and Laura Bertoni. "Food Supplements for Skin Health: In Vitro Efficacy of a Combination of Rhodiola rosea, Tribulus terrestris, Moringa oleifera and Undaria pinnatifida on UV-Induced Damage." Cosmetics 10, no. 3 (May 19, 2023): 83. http://dx.doi.org/10.3390/cosmetics10030083.

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An increasing number of people seek treatment for aging-related conditions. Plant-derived nutraceuticals are currently of great interest in the setting of dermo-cosmetic studies for their preventive role in photoaging. We conducted an in vitro study on the possible preventive properties against photoaging of a commercially available product (Venerinase®). A mixture of Rhodiola rosea, Tribulus terrestris, Moringa oleifera, Undaria pinnatifida, folic acid and vitamin B12 (Venerinase®) was tested for its potential anti-aging effects on the skin in vitro. Conventional histology, immunofluorescence and real time PCR were employed in the research protocol. The tested product was proven to prevent UV-induced morphological changes both in keratinocytes and fibroblasts. Moreover, senescence-related and proinflammatory pathways commonly triggered by UV exposure were demonstrated to be inhibited by Venerinase® pretreatment. Our results support the potential clinical benefits of oral supplements for the treatment and/or prevention of cutaneous photodamage.

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27

Bianchi, P., C. Jacques-Jamin, N. Roullet, C. Satge, F. Carballido, S. Bessou-Touya, and H. Duplan. "149 Dermo-cosmetic formulations containing Rhealba® oat sap improve fragile skin barrier function and protect against pollution." Journal of Investigative Dermatology 141, no. 10 (October 2021): S173. http://dx.doi.org/10.1016/j.jid.2021.08.152.

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28

Patrick, B., N. Thérèse, J. Séverine, L. Priscilla, B. Sandrine, R. Ana-Beatris, and D. Hélène. "767 Pre-clinical and clinical efficacy of a dermo-cosmetic skin lightening cream in women suffering from melasma." Journal of Investigative Dermatology 137, no. 5 (May 2017): S132. http://dx.doi.org/10.1016/j.jid.2017.02.792.

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29

Raszewska-Famielec, Magdalena, and Jolanta Flieger. "Nanoparticles for Topical Application in the Treatment of Skin Dysfunctions—An Overview of Dermo-Cosmetic and Dermatological Products." International Journal of Molecular Sciences 23, no. 24 (December 15, 2022): 15980. http://dx.doi.org/10.3390/ijms232415980.

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Nanomaterials (NM) arouse interest in various fields of science and industry due to their composition-tunable properties and the ease of modification. They appear currently as components of many consumer products such as sunscreen, dressings, sports clothes, surface-cleaning agents, computer devices, paints, as well as pharmaceutical and cosmetics formulations. The use of NPs in products for topical applications improves the permeation/penetration of the bioactive compounds into deeper layers of the skin, providing a depot effect with sustained drug release and specific cellular and subcellular targeting. Nanocarriers provide advances in dermatology and systemic treatments. Examples are a non-invasive method of vaccination, advanced diagnostic techniques, and transdermal drug delivery. The mechanism of action of NPs, efficiency of skin penetration, and potential threat to human health are still open and not fully explained. This review gives a brief outline of the latest nanotechnology achievements in products used in topical applications to prevent and treat skin diseases. We highlighted aspects such as the penetration of NPs through the skin (influence of physical–chemical properties of NPs, the experimental models for skin penetration, methods applied to improve the penetration of NPs through the skin, and methods applied to investigate the skin penetration by NPs). The review summarizes various therapies using NPs to diagnose and treat skin diseases (melanoma, acne, alopecia, vitiligo, psoriasis) and anti-aging and UV-protectant nano-cosmetics.

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30

Crivellari, Ilaria, Silvia Vertuani, Yunsook Lim, Franco Cervellati, Anna Baldisserotto, Stefano Manfredini, and Giuseppe Valacchi. "ES2 as a Novel Verbascoside-Derived Compound in the Treatment of Cutaneous Wound Healing." Cosmetics 5, no. 4 (November 7, 2018): 65. http://dx.doi.org/10.3390/cosmetics5040065.

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Several pathologies are characterized by chronic wounds and often resistant to many of the common therapies, leading to chronic infections that can become even life-threatening for patients. For this reason, the identification of new products able to ameliorate the healing process is still an on-going research. Natural compounds have been used to improve skin conditions due to their dermo-cosmetic and therapeutic activities including anti-inflammatory, antioxidant and cell-migratory properties. Among these compounds, it has been recently demonstrated that Verbascoside, a phenyl propanoid glycoside widely used in the cosmetic field, can improve keratinocytes proliferation. Because of its high hydrophilic character, Verbascoside has a limited range of possible topical applications and the synthesis of ES2, a semi-synthetic derivative of Verbascoside was performed to bypass some of the drawback aspects of this molecule. In the present study, the wound healing properties of Verbascoside and ES2 were compared in both keratinocytes “in vitro” wound scratch and in wounded SKH1 mice. The results showed that both compounds were not cytotoxic and ES2 showed an efficient ability to promote the proliferation of human keratinocytes compared to Verbascoside. The findings were also confirmed in vivo but only at early time points (2/3 days). Taken together, these data suggest that the Verbascoside-derivative ES2 could be considered a novel and promising candidate for the topical treatment of wounds.

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Mascarenhas-Melo, Filipa, André R. T. S. Araújo, Márcio Rodrigues, Ankita Mathur, Maria Beatriz S. Gonçalves, Kalpita Tanwar, Fariba Heidarizadeh, et al. "Dermatological Bioactivities of Resveratrol and Nanotechnology Strategies to Boost Its Efficacy—An Updated Review." Cosmetics 10, no. 3 (April 24, 2023): 68. http://dx.doi.org/10.3390/cosmetics10030068.

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Resveratrol is a polyphenolic phytoalexin, whose main natural sources are red grapes, red wine, berries, and peanuts. When applied to the skin, resveratrol evidences a good penetrating capacity and low degradation compared to the oral route, allowing for a longer and improved topical effect. This bioactive molecule has been gaining interest in dermo-pharmacy and cosmetics for the prevention and treatment of skin alterations. Its inherent meritorious biomedical potentials, including anti-aging, photoprotective, estrogen-like, skin-whitening, anti-acne, wound healing, anti-scarring, antimicrobial, and anti-skin cancer properties are the most evident. However, resveratrol evidences stability hurdles, becoming an unstable molecule when exposed to ultraviolet radiation. Several technological strategies have been developed to improve its stability, efficacy, and safety. We have described the main topical properties of resveratrol, and the involved mechanisms of action, and a great focus was placed on the technological strategies for the efficient application of resveratrol in dermatological and cosmetic formulations, including nanotechnology.

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Salazar, Javier, Thais Carmona, Flavia C. Zacconi, Diego Venegas-Yazigi, Claudio Cabello-Verrugio, Won Il Choi, and Cristian Vilos. "The Human Dermis as a Target of Nanoparticles for Treating Skin Conditions." Pharmaceutics 15, no. 1 (December 20, 2022): 10. http://dx.doi.org/10.3390/pharmaceutics15010010.

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Skin has a preventive role against any damage raised by harmful microorganisms and physical and chemical assaults from the external environment that could affect the body’s internal organs. Dermis represents the main section of the skin, and its contribution to skin physiology is critical due to its diverse cellularity, vasculature, and release of molecular mediators involved in the extracellular matrix maintenance and modulation of the immune response. Skin structure and complexity limit the transport of substances, promoting the study of different types of nanoparticles that penetrate the skin layers under different mechanisms intended for skin illness treatments and dermo-cosmetic applications. In this work, we present a detailed morphological description of the dermis in terms of its structures and resident cells. Furthermore, we analyze the role of the dermis in regulating skin homeostasis and its alterations in pathophysiological conditions, highlighting its potential as a therapeutic target. Additionally, we describe the use of nanoparticles for skin illness treatments focused on dermis release and promote the use of metal-organic frameworks (MOFs) as an integrative strategy for skin treatments.

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33

Jouravel, Glorianne, Samuel Guénin, François-Xavier Bernard, Claire Elfakir, Philippe Bernard, and Franck Himbert. "New Biological Activities of Lythrum salicaria L.: Effects on Keratinocytes, Reconstructed Epidermis and Reconstructed Skins, Applications in Dermo-Cosmetic Sciences." Cosmetics 4, no. 4 (November 25, 2017): 52. http://dx.doi.org/10.3390/cosmetics4040052.

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34

Bergera-Virassamynaïk, Sandrine, Nathalie Ardiet, and Michèle Sayag. "Evaluation of the Efficacy of an Ecobiological Dermo-Cosmetic Product to Help Manage and Prevent Relapses of Eyelid Atopic Dermatitis." Clinical, Cosmetic and Investigational Dermatology Volume 16 (March 2023): 677–86. http://dx.doi.org/10.2147/ccid.s401576.

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35

McGuckin, C., M. Frechet, M. Lègues, C. Gonindard, C. Milet, R. Boisseau, R. Besseyre, et al. "832 3D Bioprinted vascularized human skin models can be used to screen modulators of angiogenesis for medical and dermo-cosmetic applications." Journal of Investigative Dermatology 142, no. 8 (August 2022): S144. http://dx.doi.org/10.1016/j.jid.2022.05.846.

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36

Stockman, A., A. Belpaire, I. M. Hadshiew, M. Žemličkova, T. Vergou, F. Navarro Triviño, A. Márquez García, M. Vasco, B. K. Vazharova, and F. Carballido. "Dermo‐cosmetic spray containing Rhealba oat plantlets and Uncaria tomentosa extract in patients with mild‐to‐moderate cutaneous pain." Journal of the European Academy of Dermatology and Venereology 36, S4 (February 2022): 3–11. http://dx.doi.org/10.1111/jdv.17876.

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37

Ribet, Virginie, Ewa Mielewczyk, Anne Sirvent, Victor Georgescu, and Ana Beatris Rossi. "A novel dermo-cosmetic product containing thermal spring water, sucralfate, copper sulfate, and zinc sulfate in the management of hand eczema." Clinical, Cosmetic and Investigational Dermatology Volume 11 (July 2018): 373–81. http://dx.doi.org/10.2147/ccid.s157849.

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38

Buche, P., L. Violin, and P. Girard. "Evaluation of the effects of cosmetic or dermo-pharmaceutical products on cutaneous energy metabolism using the Episkin model of reconstructed epidermis." Cell Biology and Toxicology 10, no. 5-6 (December 1994): 381–85. http://dx.doi.org/10.1007/bf00755786.

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39

França, Carla Giometti, Denise Gradella Villalva, and Maria Helena Andrade Santana. "Oxi-HA/ADH Hydrogels: A Novel Approach in Tissue Engineering and Regenerative Medicine." Polysaccharides 2, no. 2 (June 7, 2021): 477–96. http://dx.doi.org/10.3390/polysaccharides2020029.

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Hyaluronic acid (HA) is a natural polyelectrolyte abundant in mammalian connective tissues, such as cartilage and skin. Both endogenous and exogenous HA produced by fermentation have similar physicochemical, rheological, and biological properties, leading to medical and dermo-cosmetic products. Chemical modifications such as cross-linking or conjugation in target groups of the HA molecule improve its properties and in vivo stability, expanding its applications. Currently, HA-based scaffolds and matrices are of great interest in tissue engineering and regenerative medicine. However, the partial oxidation of the proximal hydroxyl groups in HA to electrophilic aldehydes mediated by periodate is still rarely investigated. The introduced aldehyde groups in the HA backbone allow spontaneous cross-linking with adipic dihydrazide (ADH), thermosensitivity, and noncytotoxicity to the hydrogels, which are advantageous for medical applications. This review provides an overview of the physicochemical properties of HA and its usual chemical modifications to better understand oxi-HA/ADH hydrogels, their functional properties modulated by the oxidation degree and ADH concentration, and the current clinical research. Finally, it discusses the development of biomaterials based on oxi-HA/ADH as a novel approach in tissue engineering and regenerative medicine.

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Angelis, Apostolis, Jane Hubert, Nektarios Aligiannis, Rozalia Michalea, Amin Abedini, Jean-Marc Nuzillard, Sophie Gangloff, Alexios-Leandros Skaltsounis, and Jean-Hugues Renault. "Bio-Guided Isolation of Methanol-Soluble Metabolites of Common Spruce (Picea abies) Bark by-Products and Investigation of Their Dermo-Cosmetic Properties." Molecules 21, no. 11 (November 21, 2016): 1586. http://dx.doi.org/10.3390/molecules21111586.

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41

Polena, Helena, Marlène Chavagnac-Bonneville, and Michèle Sayag. "Improvement of Quality of Life in Dialysis and Diabetic Patients by Skin Dryness and Pruritus Management with an Ecobiological Dermo-Cosmetic Product." Clinical, Cosmetic and Investigational Dermatology Volume 15 (October 2022): 2143–52. http://dx.doi.org/10.2147/ccid.s375472.

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42

Ribet, V., M. Gurdak, P. ‐J Ferret, E. Brinio, F. Giordano Labadie, and A. B. Rossi. "Stepwise approach of development of dermo‐cosmetic products in healthy and atopic dermatitis paediatric population: safety evaluation, clinical development and postmarket surveillance." Journal of the European Academy of Dermatology and Venereology 33, no. 12 (August 30, 2019): 2319–26. http://dx.doi.org/10.1111/jdv.15785.

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43

Cassuto, Daniel, Jean‐Francois Mollia, Luca Scrimali, and Paolo Siragò. "Right–left comparison study of hydrogel pad versus transparent fluid gel in patients with dermo‐cosmetic lesions undergoing non‐ablative laser therapy." Journal of Cosmetic and Laser Therapy 11, no. 1 (January 2009): 45–51. http://dx.doi.org/10.1080/14764170802663169.

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44

Carvalho, Glaucimeire R., Débora S. Braz, Talita C. O. Gonçalves, Rafaela Aires, Larissa Z. Côco, Marcio Guidoni, Marcio Fronza, et al. "Development and Evaluation of Virola oleifera Formulation for Cutaneous Wound Healing." Antioxidants 11, no. 9 (August 25, 2022): 1647. http://dx.doi.org/10.3390/antiox11091647.

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In regions adjacent to the Brazilian Atlantic Forest, Virola oleifera (VO) resin extract has been popularly used for decades as a skin and mucosal healing agent. However, this antioxidant-rich resin has not yet been investigated in wound healing, whose physiological process might also be aggravated by oxidative stress-related diseases (e.g., hypertension/diabetes). Our aim, therefore, was to investigate whether VO resin presents healing effects through an innovative cream for topical applications. For this, adult male Wistar rats were divided into four groups. Then, four 15 mm excisions were performed on the shaved skin. All treatments were applied topically to the wound area daily. At the end of experiments (0, 3rd, and 10th days) macroscopic analysis of wound tissue contraction and histological analysis of inflammatory cell parameters were performed. The group treated with VO cream showed the best wound contraction (15%, p < 0.05) and reduced levels of lipid peroxidation and protein oxidation (118% and 110%, p < 0.05, respectively) compared to the control group. Our results demonstrated the healing capacity of a new formulation prepared with VO, which could be, at least in part, justified by antioxidant mechanisms that contribute to re-epithelialization, becoming a promising dermo-cosmetic for the treatment of wound healing.

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Nobile, Vincenzo, Daniela Buonocore, Angela Michelotti, and Fulvio Marzatico. "Anti‐aging and filling efficacy of six types hyaluronic acid based dermo‐cosmetic treatment: double blind, randomized clinical trial of efficacy and safety." Journal of Cosmetic Dermatology 13, no. 4 (November 17, 2014): 277–87. http://dx.doi.org/10.1111/jocd.12120.

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46

Fournière, Mathilde, Gilles Bedoux, Nicolas Lebonvallet, Raphaël Leschiera, Claudie Le Goff-Pain, Nathalie Bourgougnon, and Thomas Latire. "Poly- and Oligosaccharide Ulva sp. Fractions from Enzyme-Assisted Extraction Modulate the Metabolism of Extracellular Matrix in Human Skin Fibroblasts: Potential in Anti-Aging Dermo-Cosmetic Applications." Marine Drugs 19, no. 3 (March 17, 2021): 156. http://dx.doi.org/10.3390/md19030156.

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Ulva sp. is known to be a source of bioactive compounds such as ulvans, but their biological activity on human dermal fibroblast extracellular matrix (ECM) is poorly reported. In this work, the regulation of ECM has been investigated for the first time at both proteomic and transcriptomic levels in normal human skin dermal fibroblasts, after 48 h of incubation with poly- and oligosaccharide fractions from Ulva sp. obtained after enzyme-assisted extraction and depolymerization. Cell proliferation enhancement (up to +68%) without exhibiting any cytotoxic effect on fibroblasts was demonstrated at 50 and 1000 µg/mL by both fractions. At the proteomic level, polysaccharide fractions at 1000 µg/mL enhanced the most the synthesis of glycosaminoglycans (GAGs, up to +57%), total collagen, especially types I (up to +217%) and III, as well as the synthesis and activity of MMP-1 (Matrix Metalloproteinase-1, up to +309%). In contrast, oligosaccharide fractions had no effect on GAGs synthesis but exhibited similarities for collagens and MMP-1 regulation. At the transcriptomic level, the decrease of COL1A1 and COL1A2 expression, and increase of COL3A1 and MMP-1 expression, confirmed the modulation of ECM metabolism by both fractions. Our research emphasizes that poly- and oligosaccharide Ulva sp. fractions exhibit interesting biological activities and supports their potential use in the area of skin renewal for anti-aging dermo-cosmetic applications.

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Negreanu-Pirjol, T., R. Sirbu, and M. Mirea. "Antioxidant Activity Correlated with Chlorophyll Pigments and Magnesium Content of Some Green Seaweeds." European Journal of Medicine and Natural Sciences 3, no. 1 (May 15, 2020): 107. http://dx.doi.org/10.26417/393qel95l.

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The complex valorification of seaweed biomass represents a highly important resource for the pharmaceutical and dermo-cosmetic industry, supplying raw material for the extraction of bioactive substances such as, polysaccharides, vitamins, sterols, aminoacids, polyphenols and minerals. Marine algae represent an indefatigability resource of therapeutic active principles for diseases treatment of magnesium deficiency. The presence of chlorophyll pigments in the green algae confirms the magnesium existence, as central element in molecular structures. The main green algae, as Ulva lactuca and Enteromorpha intestinalis present on the Romanian Black Sea Coast, belong to Chlorophyta sp. In this paper we present a study of antioxidant activity correlated with magnesium content and chlorophyll pigments of the green algae Enteromorpha intestinalis and Ulva rigida (syn. Ulva lactuca) hydroalcoholic extracts. For chlorophyll pigments determination, the UV-Vis spectrometry was used. Magnesium content had been determined by absorption atomic spectrometry method, using HR-CS- AAS ContraA 700 apparatus, Analytik Jena and for total antioxidant capacity of green algae extracts, the photochemiluminescence method had been applied, using Photochem Analytik Jena apparatus. The comparative studies on two marine green algae extracts confirm the high magnesium content correlated with a high level of total antioxidant capacity for both species. The results obtained emphasize the possibility to enlarge the options to use these natural vegetal resources from Black Sea Coast, in different degenerative diseases therapy.

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48

Fournière, Mathilde, Gilles Bedoux, Djouhar Souak, Nathalie Bourgougnon, Marc G. J. Feuilloley, and Thomas Latire. "Effects of Ulva sp. Extracts on the Growth, Biofilm Production, and Virulence of Skin Bacteria Microbiota: Staphylococcus aureus, Staphylococcus epidermidis, and Cutibacterium acnes Strains." Molecules 26, no. 16 (August 6, 2021): 4763. http://dx.doi.org/10.3390/molecules26164763.

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Ulva sp. is known to be a source of bioactive compounds such as ulvans, but to date, their biological activity on skin commensal and/or opportunistic pathogen bacteria has not been reported. In this study, the effects of poly- and oligosaccharide fractions produced by enzyme-assisted extraction and depolymerization were investigated, for the first time in vitro, on cutaneous bacteria: Staphylococcus aureus, Staphylococcus epidermidis, and Cutibacterium acnes. At 1000 μg/mL, poly- and oligosaccharide fractions did not affect the growth of the bacteria regarding their generation time. Polysaccharide Ulva sp. fractions at 1000 μg/mL did not alter the bacterial biofilm formation, while oligosaccharide fractions modified S. epidermidis and C. acnes biofilm structures. None of the fractions at 1000 μg/mL significantly modified the cytotoxic potential of S. epidermidis and S. aureus towards keratinocytes. However, poly- and oligosaccharide fractions at 1000 μg/mL induced a decrease in the inflammatory potential of both acneic and non-acneic C. acnes strains on keratinocytes of up to 39.8%; the strongest and most significant effect occurred when the bacteria were grown in the presence of polysaccharide fractions. Our research shows that poly- and oligosaccharide Ulva sp. fractions present notable biological activities on cutaneous bacteria, especially towards C. acnes acneic and non-acneic strains, which supports their potential use for dermo-cosmetic applications.

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Freitas, Rafaela, Alice Martins, Joana Silva, Celso Alves, Susete Pinteus, Joana Alves, Fernando Teodoro, et al. "Highlighting the Biological Potential of the Brown Seaweed Fucus spiralis for Skin Applications." Antioxidants 9, no. 7 (July 11, 2020): 611. http://dx.doi.org/10.3390/antiox9070611.

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Skin aging is a biological process influenced by intrinsic and extrinsic factors. The last ones, mainly exposure to UV radiation, increases reactive oxygen species (ROS) production leading to a loss of extracellular matrix, also enhanced by enzymatic degradation of matrix supporting molecules. Thus, and with the growing demand for eco-friendly skin products, natural compounds extracted from brown seaweeds revealed to be good candidates due to their broad range of bioactivities, especially as antioxidants. The aim of this study was to assess the dermo-cosmetic potential of different fractions obtained from the brown seaweed Fucus spiralis. For this purpose, in vitro antioxidant (Total Phenolic Content (TPC), 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, Ferric Reducing Antioxidant Power (FRAP), Oxygen Radical Absorbance Capacity (ORAC)), anti-enzymatic (collagenase, elastase and hyaluronidase), antimicrobial, anti-inflammatory (NO production) and photoprotective (ROS production) capacities were evaluated. Although nearly all fractions evidenced antioxidant effects, fraction F10 demonstrated the highest antioxidant ability (EC50 of 38.5 µg/mL, DPPH assay), and exhibited a strong effect as an inhibitor of collagenase (0.037 µg/mL) and elastase (3.0 µg/mL). Moreover, this fraction was also the most potent on reducing ROS production promoted by H2O2 (IC50 of 41.3 µg/mL) and by UVB (IC50 of 31.3 µg/mL). These bioactivities can be attributed to its high content of phlorotannins, as evaluated by LC-MS analysis, reinforcing the potential of F. spiralis for further dermatological applications.

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Bensignor, Emmanuel, Yoshiko Sonoo, Atsuo Asano, Tamio Omuro, Motoki Taketani, Jun Ando, and Masahiko Nagata. "Open Study for Dermo-cosmetic Evaluation of a Spot-on Formulation Composed of Essential Oils and Essential Fatty Acids for Dogs and for Cats in Japan." Japanese Journal of Veterinary Dermatology 15, no. 1 (2009): 19–26. http://dx.doi.org/10.2736/jjvd.15.19.

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