Log in

Relevant bibliographies by topics / Derivative action / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Derivative action.

Dissertations / Theses on the topic 'Derivative action'

Author: Grafiati

Published: 4 June 2021

Last updated: 8 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Derivative action.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Abbas, Aamir. "A functional derivative action framework for Pakistan." Thesis, University of Bedfordshire, 2017. http://hdl.handle.net/10547/622522.

Full text

Abstract:

Company law in Pakistan does not recognise shareholders’ right of derivative action. This situation raises the question as to what extent derivative action, if recognised under the company law in Pakistan, can promote good corporate governance and contribute to reinforce enforcement powers of shareholders as to safeguarding their rights? The purpose of this thesis is twofold. First, this thesis argues that an effective derivative action system could act as a means of disciplining corporate management in Pakistan. Second, it presents it argumentations that other legal and extra-legal managerial disciplinary mechanisms have limitations of their own that support the introduction of a statutory derivative action system in Pakistan. The methodologies used in this thesis are doctrinal, historical, case study, comparative and semi-structured interviews. Doctrinal analysis has been employed when analysing statutes and case law. Case study methodology has been used to exemplify problems of directorial misconduct and providing empirical evidence for carrying out further analysis. A comparative approach has been utilized for which the UK has been chosen for comparative purposes to identify lessons that Pakistan can learn from the UK derivative action system while finding ways for effective use of derivative action system in Pakistan. Semi-structured interviews are aimed at providing an evaluation of the reform proposals. This study contributes to the subject of derivative action in three key ways. First, it provides an in-depth examination of the regulatory framework pertaining to shareholder protection in Pakistan in order to highlight the inherent challenges presented by un-updated legal framework. Second, based on the findings from this thesis, reform proposals are made as to codifying derivative actions, clarifying the procedural route for derivative proceedings and providing a funding mechanism to attract shareholders to bring derivative actions to enforce corporate rights. Third, suggestions proposed in this thesis are supported by both the opinions of the interviewees and original research on judicial experience of other jurisdictions, particularly the UK. The findings made in this study and proposals have implications for law reforms and are expected to inform practitioners, academics, legislators and policy makers on the way forward in reforming shareholder protection in Pakistan. Thus, this thesis would inform reforms in the company law in order to strengthen the enforcement power of shareholders and ensure corporate accountability in Pakistan.

APA, Harvard, Vancouver, ISO, and other styles

2

Zuk, J. A. "Derivative expansion of the one-loop effective action." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355815.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Jiang, Yun. "Comparative study on the history of derivative action." Thesis, University of Macau, 2016. http://umaclib3.umac.mo/record=b3525657.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Cabral, Harsha, and n/a. "Corporate law, derivative actions : a comparative approach." University of Canberra. Law, 1999. http://erl.canberra.edu.au./public/adt-AUC20060622.163443.

Full text

Abstract:

This thesis is a culmination of a research of a particular branch of Corporate Law, which has grown in several major parts of civilized jurisdictions. The thrust of the study was to evaluate the past, present and the future of a particular type of action known in Corporate Law under the umbrella of shareholder remedies - the 'Derivative Action' with emphasis to develop the law in one jurisdiction profiting from another. The research thus reveals how, when and where the so called action originated, the initial effects these actions had on the corporate world including shareholders, companies and related persons natural or juristic. Though much has been written by way of books, treatises and articles and several researches have dealt with the common topic shareholder remedies in its broad perspect, there is no separate study carried out on this topic in its global context with a comparative focus. This study has therefore given me the drive, initiative and courage to look at the conceptual view or the macro view of the so called 'Derivative Action' with of course special emphasis on the Australian and Sri Lankan jurisdictions in its micro aspects. This, I believe is the first time anyone has undertaken such a task. The study thus travels through distant roads of common law action to the statutory form of the action in the relevant jurisdictions and finds it driving with much purpose in jurisdictions such as Australia and Sri Lanka which are both in the transitional era from the common law action to the statutory action. The research is based on the collection of material namely, case law - Australian, Sri Lankan and international on the matters in issue, Legal treatises on the subject matter local and international, Law reform material - Australian, Sri Lankan and international on the topic, Bills and Statutes available on the topic in Australia, Sri Lanka and other countries. I have met resource personnel with regard to Law Reform in several jurisdictions on the matters in issue and visited the Australian Stock Exchange and the Colombo Stock Exchange. The research findings depend mainly on the electronic data available in addition to resources available at the University of Canberra, the Australian National University, Colombo Law Library, The Colombo Law Society Library and the Sri Lanka Supreme Court Judges' Chambers Library and the Sri Lanka Attorney General's Department Library. Visits to the McGill University in Montreal, Canada and the corporate law sector in New Zealand, including Universities and Law Offices in Christchurch and Auckland too has helped me considerably in the process. Review of the literature of the proposed statutory Derivative Action in Australia and the proposed statutory Derivative Action in Sri Lanka, are based mainly on; Enforcement of the duties of directors and officers of a company by means of a statutory derivative action (Report No. 12) Companies and Securities Law Review Committee. (November 1990.), Corporate Practices and the Rights of Shareholders (Report of the House of Representatives Standing Committee on Legal and Constitutional Affairs) Parliament of the Commonwealth of Australia. (November 1991.), Report on A Statutory Derivative Action Companies and Securities Advisory Committee. (July 1993.), Corporate Law Economic Reform Program (CLERP) Proposal Paper No 3 (1997), the CLERP draft legislative provisions (1998), Australian case law on the application of the common law Derivative Action, both in the High Court and in individual States and Australian articles on Derivative Action as a common law remedy and on the introduction of the statutory action. In the Sri Lankan context, the proposals in Sri Lanka for the statutory Derivative Action and the case law in Sri Lanka on the application of the common law remedy has been referred to. Other literature include, material available on the Canadian formula of Derivative Action, including Statutes, Rules, case law, articles and other relevant data, material available on the Derivative Actions in the United States, material available in New Zealand on Derivative Actions, material available in England on Derivative Actions, namely on the common law approach, case law, articles, Bills, Rules and other connected material, Statutes on Derivative Actions in other jurisdictions at present and Hong Kong proposals for a statutory Derivative Action, to name some. The aforesaid material and the review of the same have assisted the study as follows: -To place the past, present and the future of the common law Derivative Action. -Examine the objectives of the Derivative Action. -The operation of the common law aspects of the action. -The benefits of the statutory form of the action. -Experiences of other countries in the recent past on the subject. -The Australian reform process presently underway. -The best experiences in Australia with regard to case law. -To evaluate whether the remedy should be limited to fraud on the minority or whether it should be extended further even to negligence. -How best Sri Lanka could benefit from the Australian formula of the statutory form of the action. -To evaluate whether the proposed model of the statutory action in Sri Lanka is adequate in view of the Australian and other accepted formulae on the subject. -Whether the common law action should be expressly abolished in Sri Lanka. -Consider the possible introduction of the best methods to Sri Lanka. Finally, the research speaks for itself the need for a statutory Derivative Action for Sri Lanka in the future, to be an improvement on the Canadian, New Zealand and Australian models. The research findings, especially in its conclusions and recommendation in Chapter 8, will no doubt help to improve the proposed statutory Derivative Action in Sri Lanka in a small way.

APA, Harvard, Vancouver, ISO, and other styles

5

Weir, William Alexander. "Higher derivative terms and their influence on N=2 supersymmetric systems." Thesis, Durham University, 1999. http://etheses.dur.ac.uk/4290/.

Full text

Abstract:

This thesis is concerned with so-called higher derivative terms which arise in low energy approximations to certain physical models. In particular, the aim is to investigate the role that such terms play in low energy N=2 supersymmetric gauge theories in 4 dimensions, with gauge group SU(2).Chapter one serves as an introduction to the notions of supersymmetry and superfields. The problem of constructing an effective action which describes the low energy dynamics is introduced, and the construction of the Wilsonian action in terms of light and heavy modes is developed. The concept on a derivative expansion is also described. Chapter two introduces N=2 supersymmetric gauge theories with spontaneous symmetry breaking. It is observed that such systems always have a Bogomolnyi bound, and the consequences are discussed. We then develop a derivative expansion of this system in terms of N=2 superfields, drawing particular attention to the next-to- leading order derivative term (that is, those with 4 derivatives/8 fermions). The duality properties of such a term are reviewed, and their impact on the mass formula discussed. Conclusions are drawn as to their influence on the results of Seiberg and Witten. Chapter three deals with a non-renormalisation theorem for the next-to-leading order higher derivative term proposed by Dine and Seiberg. This states that instanton contributions to such a term in massless N=2 SU(N(_c)) gauge theories vanish when the number of flavours N(_f) = 2N(_c). We prove this result using the ADHM formalism for multi-instantons in the case N(_c) = 2.

APA, Harvard, Vancouver, ISO, and other styles

6

Zhang, Zhong. "Derivative action and good governance in China : : economic theories and legal rules." Thesis, University of Manchester, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.488053.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Reisberg, Arad. "The derivative action as a corporate governance tool : a functional and focused approach." Thesis, University of Oxford, 2005. https://ora.ox.ac.uk/objects/uuid:d1e73f2c-0d9b-4ece-ba72-52ed555c5d26.

Full text

Abstract:

This thesis of 98,273 words is concerned with one of company law's most thorny aspects: the derivative action. The thesis has both a positive and a normative dimension. It takes a position about the role that derivative action litigation should have in the corporate governance matrix. This is the realm of the normative, the domain of what some political philosophers call 'ideal theory'. However the analysis here aims not to be merely a philosophical flight of fantasy about how things ought to be, but rather aims to provide insight into current practice and to suggest substantive viable improvements. In view of this, this analysis can be used both to understand substantial and procedural rules governing the derivative action and judicial decisions in this area, and to suggest how problems should be resolved in the future, judicially and legislatively. First, the thesis attempts a fundamental rethink of the content of the derivative action and its objectives. It attempts to clarify the nature of the action and the circumstances in which its application may be deemed propitious. The thesis then focuses on and examines the conditions that may produce a positive inducement to litigate. It expresses a view on what might be the optimal level of such litigation with a view to enhancing the potential effectiveness of the action. Crucially, it strongly links the actual viability of derivative actions to funding mechanisms, namely developing adequate means to fund derivative actions so as to make them worthwhile financially. Finally, the thesis argues that it is vital to clarify the interaction between the primary remedies available to shareholders. More specifically, the thesis calls for action on three complementary levels, namely, conceptual the adoption of a new framework in the guise of the Functional and Focused Model ('FFM') to govern derivative action litigation; strategic the employment of appropriate incentives and fee rules which advance the premises behind the FFM; and, finally, maintaining doctrinal consistency - by clarifying the interaction between the derivative action and the unfair prejudice remedy.

APA, Harvard, Vancouver, ISO, and other styles

8

Aleshaikh, Abdullatif Mohammed. "Towards legal reform of Saudi law of directors' duties and of enforcement by derivative action." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/30630/.

Full text

Abstract:

Directors’ duties of care and loyalty and their enforcement by derivative action, are important elements in the company law system. Such mechanisms are introduced to ensure that directors are subject to a satisfactory level of accountability and control while managing a company. This research employed the comparative law approach to identifying problems in, and to proposing reform for, the Saudi Arabian law of directors’ duty to act with care and in good faith in the company’s general interests, and to avoid conflicts of interest, with particular focus on the corporate opportunities and self-dealing transactions and the Saudi law of derivative actions. The main objective of this study was to propose a reform of Saudi law of directors’ duties and of derivative actions. By using the company law of the United Kingdom (UK) as benchmark, this study evaluates the clarity, certainty and accessibility of Saudi law and identifies weaknesses and deficiencies. The feasibility of transplanting selective legal ideas and rules from the UK company law to its Saudi counterpart in order to develop a framework for legal reform in Saudi Arabia is examined. The argument here is that the Saudi law of directors’ duties of care and loyalty and derivative actions suffers from serious deficiencies, despite the introduction of the new Companies Law of 2015. While the new Saudi Corporate Governance Regulations 2017 have tackled some issues in the areas of directors’ duties, there is still room for improvement. The uncertainty in the law of directors’ duties and enforcement is sufficient in itself to justify the reform of law. Moreover, the limits of other legal and non-legal mechanisms of accountability in the Saudi context suggest that alternative mechanisms would not adequately ensure the accountability of directors. Throughout the examination of the feasibility of reform by way of legal transplantation, the study takes into account that the UK legal model is only transferable if it can be adapted to fit within the institutional structure and legal environment in Saudi Arabia. This is necessary to ensure proper reception of foreign rules by the new environment of the host country. The finding is that transferability of most UK legal models and rules is feasible. Throughout this consideration of a reform agenda for the Saudi law of directors’ duties and derivative actions, the research has been guided by a policy that requires striking a balance between the need to increase directors’ accountability and the need to protect the directors’ exercise of their managerial authority.

APA, Harvard, Vancouver, ISO, and other styles

9

Sonqishe, Thantaswa Millecent. "Treatment of brines using commercial zeolites and zeolites synthesized from fly ash derivative." Thesis, University of the Western Cape, 2008. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_6127_1297842299.

Full text

Abstract:

The objectives of this project was to ameroliate two waste materials, namely Acid Mine Drainage and Fly Ash and recover the solid residues for conversion into an adsorbent to treat brine. The solid residues were then converted into zeolite P through low temperature hydrothermal treatment. The adsorption capacity of the solid residues, zeolite P derived from the solid residues was compared to the commercial zeolite Y and fresh Arnot fly ash. The quality of the resulting water was assessed using different analytical methods before the reaction with adsorbents and after the reaction and a comparison was done based on the removal efficiency of elements Zeolite P from solid residues was successfully synthesized as confirmed by XRD, BET and FTIR. Brine treatment with fly ash, solid residues, zeolite P and commercial zeolite Y adsorbents was done concentration on the following major elements Na, K, Mg, Ca and Si. Zeolite P had higher or similar removal efficiency that the commercial zeolite Y for the following elements K, Ca and Mg. Fly ash is the only adsorbent that managed to reduce the concentration of Na in brine and also had a good removal efficiency of Mg. Si leached out of all the adsorbents which could be ascribed to Si being the major component of these adsorbents which could indicate some dissolution of these adsorbents under the conditions tested. Overall, zeolite P did not completely remove the major elements, especially for Na, but did result in a cleaner waste stream which would improve brine processing.

APA, Harvard, Vancouver, ISO, and other styles

10

Ta, Isabelle. "Le renouveau de l'action oblique." Thesis, Paris 1, 2018. http://www.theses.fr/2018PA01D070.

Full text

Abstract:

L'action oblique, ou la faculté pour le créancier de préserver son droit de gage général en exerçant les droits et actions négligés par son débiteur, est de ces mécanismes simples que l'on n'interroge plus. Le simple toilettage du texte du Code civil opéré par l'ordonnance du 10 février 2016 conforte cette attitude. La stabilité de son analyse n'est cependant due qu'à d'insatisfaisants compromis. Irréductible à une qualification unique de mesure conservatoire ou de voie d'exécution, la protection du droit de gage général que poursuit le créancier est en réalité duale : le créancier de somme d'argent cherche tantôt à assurer l'efficacité ultérieure de son droit de saisie, tantôt à obtenir immédiatement paiement. Ces fonctions traditionnelles, pour lesquelles l'action oblique est inadaptée, coexistent aux côtés d'une fonction nouvelle : prémunir le créancier d'obligation en nature et le titulaire de droits assimilés de toute atteinte à leurs droits. Mécanisme d'exécution forcée par obligation tierce préexistante, elle peut alors être utilisée en lieu et place de la responsabilité délictuelle du débiteur défaillant à l'égard de certains tiers. Cette évolution de la fonction de l'action oblique était contenue en germe dans son mécanisme. Le renouveau des fonctions s'explique par un renouveau de l'analyse de sa nature. Autorisant l'exercice des droits d'autrui, l'action oblique ne repose pas sur la représentation mais sur un droit propre original de substitution. Sans qu'ils soient réellement modifiés, cette qualification confère une acception nouvelle au domaine et une justification inédite au régime de l'action oblique, et ce tant dans ses conditions que dans ses effets
The derivative action or the right for a creditor to claim the rights and actions of their neglectful debtor to protect their ulterior payment seems so familiar one no longer pays attention to it. This lack of attention seems all the more justified in light of the reform of February 10th 2016, which rewrote the article of the Civil Code without any real modification. But in truth, this understanding of the derivative action rests on unfulfilling compromises. Its understanding is obvious only at first glance. The derivative action can neither be reduced to a conservatory or a binding measure only, as the holder of the derivative action seeks at times to guarantee an ulterior seizing of property, and at other times to recover a debt of money. But these traditional functions, for which the derivative action may not be entirely appropriate, coexist with a newer one : allowing performance for the creditor of a debt in kind and holders of similar rights. Here the derivative action could be an answer to a debtor's liability towards specific third parties. This evolution could already be foreseen in the very mechanism of the derivative action. Actually, the renewed functions of the mechanism can be explained by the renewed attention paid to the analysis of its nature. By allowing one to exert a third party’s rights, the derivative action relies not on representation but on an original right of substitution. This new analysis brings along a new definition of the extent to which one is allowed to exert a third party’s rights, as well as a new explanation about both the circumstances and effects of the derivative action

APA, Harvard, Vancouver, ISO, and other styles

11

Stylianou, Alexandra. "Evolution of the derivative action as an enforcement of rights mechanism under the Companies Act 71 of 2008." Diss., University of Pretoria, 2016. http://hdl.handle.net/2263/60099.

Full text

Abstract:

The purpose of this dissertation a focus on derivative actions as a method a minority shareholder can employ as an enforcement of rights mechanism. In so doing I will be examining the derivative action procedure from its inception in the common law through to the current dispensation. This dissertation describes and explains the rights, interests and obligations of shareholders and will explore the pitfalls for shareholders in the implementation of the derivative action as a protective measure. I submit that the derivative action found under the common law and the previous statutory regime provided the stepping stone in molding the statutory derivative action evidenced by section 165 of the Companies Act. In Chapter 1, I explore the derivative action under the common law as a conceptual framework and as a movement that initially arose in the renowned case of Foss v Harbottle. Whose core principles were subsequently embraced by the South African judiciary. In Chapter 2 I discuss the availability of the statutory derivative action and the limitations of section 266. Further, I make a comparative study between the common law and the statutory derivative action. The comparison is essential in an attempt to portray that the statutory derivative action refined the common law to a certain extent in its attempts to provide a minority shareholder protective measure. In chapter 3 I examine section 165 of the Companies Act to evaluate to what degree the derivative action has transformed against the backdrop of its statutory predecessor and the common law. This chapter breaks down the constituent principles of section 165 and examines the requirements necessary to implement the measure. Finally, in Chapter 4 I make a comparative study with foreign jurisdictions to determine the extent, if any, section 165 relates to the principles laid down in other jurisdictions.
Mini Dissertation (LLM)--University of Pretoria, 2016.
Mercantile Law
LLM
Unrestricted

APA, Harvard, Vancouver, ISO, and other styles

12

Cassim, Maleka Femida. "The statutory derivative action under the Companies Act of 2008: guidelines for the exercise of the judicial discretion." Doctoral thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/12762.

Full text

Abstract:

Includes bibliographical references
Section 165 of the Companies Act 71 of 2008 introduces the new statutory derivative action. The section confers a pivotal function on the courts as gatekeepers to the derivative action, with an important filtering or screening function to weed out applications for derivative actions that are frivolous, vexatious or without merit. The vital judicial discretion to grant leave to an applicant to bring a derivative action entails a tension between two equally important policy objectives. A proper balance between these two underpinning policy objectives depends on the appropriate judicial interpretation and application of the three vague, general and open-textured criteria or gateways for the grant of leave to institute a derivative action. The courts have been entrusted by s 165 to flesh out the details, the contours, the ambit and the scope of these criteria. This crucially gives the courts a dominant and a decisive role in shaping the effectiveness of the new statutory derivative action. This thesis makes an original contribution to knowledge in three main respects. First, this thesis focuses on the three guiding criteria for leave, and their many nuances, interpretations and applications in certain foreign jurisdictions that have exerted an influence on the provisions of s 165. Based on experience garnered from Australian, Canadian and New Zealand law, as well as the United Kingdom and the USA, guidelines are suggested for the approach that the South African courts should adopt to the three preconditions for a derivative action. Secondly, it is submitted that the real weakness in s 165 lies in the rebuttable presumption in s 165(7) and (8), which contains a fatal flaw that renders the remedy defective and calls for legislative amendment. Pending such amendment, proposals are suggested for the proper judicial approach in the meantime to the troublesome presumption. These proposals are supported by both reasoned argument and original research on experience in certain foreign jurisdictions, particularly the USA. Thirdly, and equally importantly, a framework is suggested in this thesis for the proper exercise of the judicial discretion to make orders of costs, which is known to have plagued minority shareholders wishing to bring derivative proceedings against miscreant directors who have wronged the company.

APA, Harvard, Vancouver, ISO, and other styles

13

Gubay, Finn. "Higher derivative corrections to the low-energy effective action of type IIA/B string theory and M-theory." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/higher-derivative-corrections-to-the-lowenergy-e-ective-action-of-type-iiab-string-theory-and-mtheory(775e2c55-d7de-4d43-89f4-b995fa13b640).html.

Full text

Abstract:

The type IIA and type IIB supergravity actions in d = 10 dimensions are the low-energy effective theories of type IIA and IIB string theory. In addition, the unique eleven dimensional supergravity theory is the low-energy effective action of M-theory. Higher order corrections to the low-energy effective actions of these supergravity theories contain perturbative and non-perturbative effects of the corresponding string theories and, as such, understanding the structure of the higher order terms provides an insight into the perturbative and non-perturbative formulations of string theory. The U-duality groups of type IIA/B string theory and M-theory compactified on a torus to d < 10 dimensions puts powerful constraints on the higher derivative terms in the effective actions of these theories. In particular, the higher derivative terms in d = 10 - n dimensions are required to possess coefficient functions that transform as En+1 (Z) automorphic forms. These automorphic forms are complex mathematical objects that encode all the perturbative and non-perturbative features of type II string theory and M-theory compactified on an torus to d dimensions. We investigate the structure of the higher derivative terms and their associated automorphic forms in the effective actions of type IIA/B string theory and M-theory. Constraints on automorphic forms appearing in d dimensions by dimensional reduction of arbitrary higher derivative terms in the type IIA, type IIB and M-theory effective actions to d dimensions are obtained. The behaviour of higher derivative terms in the d dimensional type II effective action in specic limits of various parameters is analysed. We derive a group theoretical interpretation for each limit. A general formula is given for a class of automorphic forms in these limits.

APA, Harvard, Vancouver, ISO, and other styles

14

Cheong, Wan-yee Ana. "A study on the embryotrophic action of the complement component-3 derivative (iC3b) in the preimplantation mouse embryo development." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B44231994.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Cheong, Wan-yee Ana, and 張韻怡. "A study on the embryotrophic action of the complement component-3 derivative (iC3b) in the preimplantation mouse embryo development." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B44231994.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Ngcobo, Blossom. "A comparative analysis of the derivative action under the Companies Act of 2008 with the Companies Act of 1973." Diss., University of Pretoria, 2019. http://hdl.handle.net/2263/77425.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Mhembere, Tarisai Valerie. "The protection of minority shareholders in South Africa: a reflection on the derivative action, appraisal rights and oppression remedy." Master's thesis, Faculty of Law, 2020. https://hdl.handle.net/11427/31715.

Full text

Abstract:

This thesis will be conducted by reviewing South African literature that is published in various primary and secondary sources. The research will refer to key South African statutes namely, the South African Companies Act, the Constitution of the Republic of South Africa, 1996 (hereafter referred to as the Constitution) and the Promotion of Access to Information Act 2 of 2000. Parallel statutes of Zimbabwe, Canada, and the United States of America will also be referenced throughout this thesis. Additionally, this thesis will review case law relating to the subject and the ratio of those cases will be analysed. The role of the courts in interpreting certain legal provisions will be important in assessing whether the courts have adopted a liberal or restrictive approach to the issue of protecting minority shareholders. A comparative analysis will be conducted to evaluate how South African company law has dealt with the issue of the protection of minority shareholders. This thesis will therefore compare and contrast South African and Zimbabwean legislation and case law on minority shareholder remedies. This will be achieved by evaluating how the two nations implement and apply legislation providing for the protection of minority shareholders. As part of this analysis, this thesis will review what Zimbabwe can learn from the South African system.

APA, Harvard, Vancouver, ISO, and other styles

18

Gallois, Julie. "L'exercice de l'action civile par l'associé." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLV016.

Full text

Abstract:

Comme toute personne susceptible de subir un préjudice, l'associé se trouve titulaire d'une action civile. Il dispose en effet de la possibilité de demander la réparation à l'auteur de la faute à l'origine de ce préjudice. Cette action civile dite individuelle peut être exercée, ou bien devant les juridictions civiles entendues au sens large, ou bien devant les juridictions répressives dans le cas où la faute ainsi commise serait infractionnelle. Mais en sa qualité de membre d'un groupement sociétaire, l'associé dispose également de la possibilité de demander la réparation du préjudice que subirait la société. Aussi, à côté de l'action civile à titre individuel, il peut exercer une autre action civile, cette fois-ci, à titre social, autrement appelée l'action civile ut singuli.Cette possibilité offerte à l'associé d'exercer deux actions se justifie par la diversité des préjudices dont il peut souffrir, particulièrement lorsqu'ils sont imputables au dirigeant de société. L'existence de ces deux actions permet ainsi, dans son principe, une meilleure réparation du préjudice subi par l'associé. Le mécanisme de l'action civile se veut donc avantageux pour l'associé.Toutefois, au-delà l'articulation parfois difficile entre les deux actions, l'action en réparation du préjudice social pouvant indirectement emporter la réparation du préjudice de l'associé, le constat selon lequel l'associé n'exerce que trop peu son action civile, principalement en raison de considérations matérielles et financières, a été dressé.Souhaitant rendre effectif coûte que coûte ce mécanisme considéré comme vertueux, le législateur et les juges, particulièrement attentifs aux besoins des victimes, donc de l'associé et de sa société, ont dès lors fait le choix de faciliter l'exercice de cette action, et ce aussi bien devant le juge civil que devant le juge pénal.Aujourd'hui, il est acquis que les diverses interventions législatives et jurisprudentielles ont eu pour conséquence de rendre l'action en réparation de l'associé, qu'elle soit exercée à titre individuel ou à titre social, davantage effective que par le passé. Reste que cette effectivité s'est faite au prix d'une part, d'un affaiblissement des conditions de forme de cette action, et d'autre part, d'un élargissement de ses conditions de fond
As any individual suffering damages, a shareholder is vested with the right to file a legal claim designed to compensate the injury suffered. He is entitled to seek compensation from the wrongdoer in Court. Under French law, such a direct lawsuit can be filed either with a civil court or a criminal one where the alleged wrong arises out of a criminal offense. In addition, as a co-owner of the corporation, a shareholder is also entitled to file a derivative claim, namely to seek redress for damages incurred by the corporation itself on its behalf. Hence alongside a direct suit, a shareholder can file a derivative claim, that is, sue on behalf of the corporation, known as "action ut singuli under French law".Such a possibility granted to a shareholder, is vindicated by various possible wrongs he has suffered, especially where they originate in an executive breaching his duties. The coexistence of both direct and derivative claims is designed to provide the aggrieved shareholder with the best possible compensation for damages suffered. Such a legal mechanism, that is, the possibility of filing two distinct legal claims is primarily intended to benefit the shareholder.Nonetheless, in addition to possible difficulties in delineating the proper articulation between those two lawsuits - for a derivative claim may indirectly lead to indemnify the wrong individually suffered by the shareholder - it has been pointed out that shareholders rarely file direct claims, mainly due to financial considerations.To enhance the efficiency of such a desirable legal mechanism, both lawmakers and courts, mindful of the needs of the aggrieved parties, that is the legal entity and the shareholder considered individually, have sought to ease recourse to such a lawsuit whether filed with criminal or civil courts.As of today, it is beyond question that both statutory acts and case law resulted in providing shareholders with greater efficiency as to their ability of obtaining redress for damages incurred, whether the suit is direct or derivative.Yet, such a renewed efficiency has been attained at the cost lowering standards as to procedural prerequisites, on the one hand, and broadening the reach of such a legal claim by means of relaxing substantive requirements on the other

APA, Harvard, Vancouver, ISO, and other styles

19

Zouridakis, Georgios. "The introduction of the derivative action into the Greek law on public limited companies as a means of shareholder protection : a comparative analysis of the British, German and Greek law." Thesis, University of Essex, 2016. http://repository.essex.ac.uk/17136/.

Full text

Abstract:

Shareholder protection has been a focal point of the Greek legislator's agenda for years. Despite a series of reforms towards the direction of shareholder empowerment, the adequacy of the existing framework remains questionable. The thesis conveys the argument that the remedies for maladministration under Greek company law remain dysfunctional and need to be reformed in order to establish an effective and competitive legal framework for shareholder protection. It is argued that such initiatives are important in order to boost investor confidence and provide an effective monitoring mechanism of corporate governance. In order to assess whether and to what extent the Greek shareholder law attains these objectives, it is examined on a comparative basis with jurisdictions which recently reformed their shareholder law; namely the United Kingdom and Germany. The thesis analyses the imperfections of Greek law. The latter is devoid of a genuine derivative action and the existing functionally equivalent mechanism is unsuitable to overcome the challenges of shareholder litigation. The relevant law is exclusionary and rather biased against individual shareholders. It deters meritorious litigation and does little to ensure that proceedings do not run contrary to the company’s interests. Much of corporate misfeasance escapes the scope and content of the existing provisions and, effectively, corporate wrongdoing is left uncompensated for and undeterred. Furthermore, the broader legal framework cannot compensate for the absence of an appropriate mechanism to enforce directors’ duties and pursue corporate claims via shareholder-initiated litigation. However, the examination of the strategies followed by the UK and Germany provides useful insights for the way forward. The rationale for and the experience from the recently introduced provisions thereto are invaluable in the thesis’ attempt to construct and propose a modern and functioning model of derivative actions for Greece.

APA, Harvard, Vancouver, ISO, and other styles

20

Koray, Zoé Zeynep Can. "Le préjudice de l'actionnaire." Thesis, Paris 2, 2018. http://www.theses.fr/2018PA020072.

Full text

Abstract:

Le préjudice de l'actionnaire est un sujet encore peu étudié en France alors qu'il soulève de nombreuses interrogations. A l'inverse de nombre de solutions reçues dans les droits étrangers, le droit français n'admet que peu sa réparation tant il reste lié à la distinction jurisprudentielle fondamentale entre préjudice purement personnel (réparable) et préjudice simple corollaire du préjudice social (non réparable). Pourtant, cette distinction n'est pas des plus satisfaisantes ni sur le plan théorique, ni sur le plan pratique. Elle est en outre remise partiellement en cause dès lors que le préjudice trouve sa source dans une infraction pénale, telle que la communication d'informations mensongères. Par ailleurs, l'internationalisation des mouvements de capitaux soulève de plus en plus fréquemment la question de la loi applicable ou du juge compétent (judiciaire ou arbitral également) relativement aux actions en justice des actionnaires. Cette étude se propose dès lors de fournir une appréciation critique du droit positif afin de tenter l'élaboration d'un droit prospectif. Les solutions existantes peuvent-elles et doivent-elles changer ? Pour adopter quel type de solutions ?
The subject of shareholder damages has seldom been studied in France. Nonetheless, it is a topic of much discussion and debate in legal circles. Unlike under some foreign laws, French law rarely permits the direct compensation of shareholder damages because of the summa divisio between the personal damage (recoverable) and the damage of the company (not recoverable). However, this distinction is not relevant both in terms of theory and practice. More doubt is cast on this distinction where the potential damage arises from an infringement of the penal law, such as the use of false or misleading information to induce shareholder reliance or action. Furthermore, the internationalisation of capital introduces conflicts of law and jurisdictional questions, asking the courts to first determine whether they are the proper authority to hear a shareholder’s case, and which nation’s laws to apply.This study presents a critical analysis of the positive law and proposes avenues of reforming French laws concerning shareholder damages. Should the existing remedies be changed ? Which remedies should be adopted to reverse the strict trends in French law against adequately compensating shareholders’ losses ?

APA, Harvard, Vancouver, ISO, and other styles

21

Lin, Shaowei. "Derivative actions in China." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9749.

Full text

Abstract:

The enactment of derivative action was expected to be actively used by shareholders to protect their interests. In fact, it turned out that this reform effort seemed futile as the right to engage in such actions was rarely exercised. This raises a question about the role of derivative actions in China; namely, should a derivative action system play a key role in protecting shareholder interests? If the answer is positive, the next question is how such a system could be improved in order to effectively discipline management. The essence of this thesis is to try to address these issues. This thesis argues that derivative action should and can play a key role in China’s corporate governance. First, minority shareholders in China face double agency problems within the company and thus protective mechanisms must be put in place. Second, this thesis formulates its argument by demonstrating the ineffectiveness of market forces and other legal methods. As a consequence, derivative action ought to retain a central role in regulating the misbehaviour of controlling shareholders and managers. After demonstrating the need to strengthen and improve derivative actions in China, this thesis starts to explore Chinas’ derivative actions system. It first examines derivative action cases before Company Law 2005. Despite the absence of a clear statutory basis for derivative actions in Company Law 1993, such cases have nevertheless appeared in the courts. After almost eight years of implementation, less than 80 cases were raised. Whilst this seems a good figure in comparison to other jurisdictions, closer examination shows this not to be the case. For example, the opacity of the demand requirement constitutes a barrier for shareholders wishing to exercise this right. More importantly, the funding rule of derivative actions is treated as the same with other forms of litigation. In view of the unique economic nature of the derivative action, a new funding rule for derivative action should be established. After discussing why derivative actions should play a significant role in monitoring management and how they should be improved, this thesis argues that shareholders are increasingly willing to take this action to protect their rights and interests because of the establishment of commercial society and the existence of the traditional culture of Legalist School. Also, the courts are more capable of dealing with derivative action cases because of the enactment of the Judges Law and the increasing recruitment of more qualified people to the judiciary. It is believed that the effectiveness of derivative action can contribute to foster good corporate governance in China.

APA, Harvard, Vancouver, ISO, and other styles

22

Paulos, Miguel Fernandes. "Higher derivative actions and holography." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608861.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Ross, Zara M. "Modes of action of antimicrobial garlic derivatives." Thesis, University of Wolverhampton, 1994. http://hdl.handle.net/2436/88279.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Maraventano, Sara. "Superspace formulation of higher-derivative actions from D-branes." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/15828/.

Full text

Abstract:

Higher-derivative operators play a fundamental role in the development of effective field theories. This thesis deals with the study of such operators in the context of the effective low-energy theory of type IIB superstring theory. In particular, we revisit a past attempt to find the supersymmetric form of the higher-derivatives for the D7-brane modulus in an orbifold compactification at the level of a globally supersymmetric theory. These higher-derivatives descend from the Dirac-Born-Infeld action of the D7-brane. Starting from the component Lagrangian the task is to identify the supersymmetric higher-derivative operator which reproduces the component terms. To this end, we develop a new systematic approach to determine this supersymmetric form and test it for the present example.

APA, Harvard, Vancouver, ISO, and other styles

25

Gumpert, Tilman von. "Rechtsfolgen einer Überschreitung des Unternehmensgegenstandes im Gemeinschaftsprivatrecht : eine rechtsvergleichende Untersuchung zum Gesellschafter- und Verkehrsschutz anhand des deutschen und englischen Kapitalgesellschaftsrechts /." Baden-Baden : Nomos-Verl.-Ges, 2002. http://www.gbv.de/dms/spk/sbb/recht/toc/339873299.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Geerts, Paul Georg Fredrik Alexander. "Enkele formele aspecten van het enquêterecht : analyse van de relevante rechtspraak /." [Deventer] : Kluwer, 2004. http://www.gbv.de/dms/spk/sbb/recht/toc/391799908.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

BRAUN, GREGORY ALBERT. "HIGHER DERIVATIVE CORRECTIONS TO EXTENDED SUPERSYMMETRIC THEORIES." University of Cincinnati / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1092857820.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Thomas, AdeÌle. "The pharmacological actions of cannabidiol and its derivatives." Thesis, University of Aberdeen, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415580.

Full text

Abstract:

- This study was directed at exploring the method(s) by which cannabidiol is capable of antagonizing the cannabinoid CB₁/CB₂ receptor agonist (R-(+)-WIN55212 in the mouse isolated vas deferens tissue preparation. - The mechanism appeared not to involve competition at the cannabinoid CB₁ receptor, since the CB₁ K_i binding potency (4.9 mM) was significantly less than the apparent K_B antagonizing potency (71.4 nM) for the antagonism of R-(+)-WIN55212 in the isolated mouse vas deferens. Additionally, the ability of cannabidiol to antagonize R-(+)-WIN55212 in the mouse isolated van deferens was not reproduced in the guinea-pig myenteric plexus-longitudinal muscle (MPLM) preparation; a tissue that like the mouse vas deferens expresses cannabinoid CB₁ receptors. - Evidence was generated that suggested the antagonism of R-(+)-WIN55212 by cannabidiol was not through a non-specific mechanism, since the pharmacological properties investigated displayed structural-dependence. Furthermore cannabidiol exhibited stereoselectivity as an antagonist of R-(+)-WIN55212. - The cannabidiol analogue, 6”-azidohex-2”-yne-cannabidiol (O-2654) displayed a higher affinity than cannabidiol for cannabinoid CB₁ receptors (K_i = 114.4 nM) and cannabinoid CB₂ receptors (K_i = 54.4 nM). Unlike, cannabidiol, O-2654, appeared to antagonize R-(+)-WIN55212 in the mouse isolated vas deferens by behaving as a neutral cannabinoid CB₁ receptor antagonist, since the apparent K_B value (85.7 nM) for this antagonism was not significantly different from the determined CB₁ K_i value. - Another analogue of cannabidiol, 7-OH-DMH-CBD, was observed to potently inhibit electrically evoked contractions of the mouse isolated vas deferens (EC₅₀ = 13.3 nM) at a putative site that was demonstrated to be a non-CB₁, non-CB₂, non-TRPV1, non-a₂-adrenergic and non-opioid molecular target that is sensitive to antagonism by cannabidiol. - Together these data have identified a novel target for cannabinoids and a cannabidiol analogue that behaves as a neutral cannabinoid CB₁ receptor antagonist.

APA, Harvard, Vancouver, ISO, and other styles

29

Fuller, S. J. "The mode of antibacterial action of 2-thiocyanatobenzamide and some of its derivatives." Thesis, University of Nottingham, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371122.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Korte, Otto. "Zur mißbräuchlichen Wahrnehmung der aktienrechtlichen Anfechtungsbefugnis /." Frankfurt am Main [u.a.] : Lang, 2003. http://www.gbv.de/dms/spk/sbb/recht/toc/365005320.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Buckshey, Sakshi. "Remineralizing action of CPP-ACP reagents on artificial carious lesions." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46848915.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Ireland, Alan C. "Metabolism and mode of action of 5-aminosalicylic acid and its derivatives." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236211.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Filippi, Beatrice Maria. "Cellular effects of phosphoinositide derivatives on the actin cytoskeleton." Thesis, Open University, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424620.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Marens, Richard Sim. "Labor's capital revisited : a social movement perspective on the fourth wave of shareholder activism /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/8754.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Bowman, Thomas R. Wright Evan P. "Possible effects of the Department of Defense acting as a buyer on the derivatives futures market." Monterey, Calif. : Naval Postgraduate School, 2009. http://edocs.nps.edu/npspubs/scholarly/MBAPR/2009/Jun/09Jun%5FBowman%5FMBA.pdf.

Full text

Abstract:

"Submitted in partial fulfillment of the requirements for the degree of Master of Business Administration from the Naval Postgraduate School, June 2009."
Advisor(s): Brook, Douglas ; Hensel, Nayantara ; Summers, Donald. "June 2009." "MBA professional report"--Cover. Description based on title screen as viewed on July 14, 2009. Author(s) subject terms: Oil, Price Elasticity of Demand, Hedging, Department of Defense, DoD, Fuel Purchases. Includes bibliographical references (p. 71-73). Also available in print.

APA, Harvard, Vancouver, ISO, and other styles

36

Cromwell, Diane. "Pancreatic beta-cell actions of nutrients and metabolizable nutrient ester derivatives." Thesis, University of Ulster, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494335.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Chan, Wing Chi. "Chemical studies on mechanism of action of the Chinese antimalarial artemisinin and its derivatives /." View abstract or full-text, 2005. http://library.ust.hk/cgi/db/thesis.pl?CHEM%202005%20CHAN.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Barron, Gemma A. "Novel bisnaphthalimidopropyl polyamine derivatives : their mode of action in a breast cancer cell system." Thesis, Robert Gordon University, 2010. http://hdl.handle.net/10059/510.

Full text

Abstract:

The synthesis and characterisation of novel bisnaphthalimidopropyl polyamine (BNIPP) derivatives, has gained pace over the last couple of years, as they have enhanced aqueous solubility, without loss of biological activity, in contrast to parent bisnaphthalimide derivatives. Recent work has shown that bisnaphthalimidopropyl spermidine (BNIPSpd) bis-intercalates to DNA, induces oxidative DNA damage, depletes polyamine levels and causes cell death, by apoptosis, in human colon cancer CaCO-2 and HT-29 cells. The aim of this thesis was to synthesise new BNIPP derivatives to highlight the important structural features required for biological activity, particularly, bisnaphthalimidopropyl functionality, and investigate their subsequent modes of action in breast cancer MDA-MB-231 and breast epithelial MCF-10A cells. Initially, work focused on determining the DNA binding affinities and biological activity of BNIPP derivatives. All BNIPP derivatives, except bisphthalimidopropyl diaminodecane (BPHPDadec) and mononaphthalimidopropylamine (NPA) (Δ Tm values of 15.8 and 10.2 °C, respectively, C50 values of > 10 μM, IC50 values of > 40 μM), exhibited strong DNA binding affinities and cytotoxic properties in both cell lines. Results indicate that BNIPP derivatives interact with DNA by bis-intercalation suggesting, therefore, that BNIPP derivatives target DNA. For the first time, an investigation into the mechanism of cellular entry, via the polyamine transport (PAT) system, was studied. However, none of the BNIPP derivatives utilised the MGBG-specific PAT system, suggesting that BNIPP derivatives utilise other modes of cellular entry. Two BNIPP derivatives, BNIPSpd and BNIPDaCHM, were further investigated, and results show that these derivatives significantly induced a dose dependent increase in DNA strand breaks from ≥ 0.1 μM, after 4 hours. BNIPSpd and BNIPDaCHM (at non toxic concentrations) also inhibited the repair of oxidative (H2O2) and methylative (MMS)-induced DNA strand breaks. Based on phosphatidylserine exposure and membrane integrity analyses, early apoptotic cell death was determined as a mode of cell death utilised by both BNIPSpd and BNIPDaCHM (5 μM), after only 0.5 hours treatment in MDA-MB-231 cells. Interestingly, BNIPDaCHM was identified, using HDAC assay kits, as a potent and selective SIRT2 enzyme inhibitor, thus, identifying, a novel structural backbone for the selective inhibition of HDAC enzymes.

APA, Harvard, Vancouver, ISO, and other styles

39

Xie, Shaoping. "Studies on the mechanisms of action of vitamin D derivatives in human breast cancer cells." Thesis, St George's, University of London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313538.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Mukinda, James Tshikosa. "Aspects of the gastrointestinal uptake and metabolism of luteolin derivatives from Artemisia afra aqueous extract (preclinical)." Thesis, University of the Western Cape, 2011. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_6962_1306817895.

Full text

Abstract:

The aim of this study was to investigate the effect the plant matrix and the structure of the flavonoid (i.e. whether aglycone or glycoside) may have on the gastrointestinal uptake and metabolism of luteolin derivatives from Artemisia afra traditional plant medicine. Specifically, how these two factors influenced the intestinal uptake and disposition of luteolin derivatives in pure and in Artemisia afra plant extract forms were to be assessed by investigating the uptake and metabolism of the luteolin derivatives in human intestinal epithelial Caco-2 cells and the perfused rat intestinal loop. To realize this aim, the following were determined: (1) identification and characterization of major luteolin derivatives found in Artemisia afra, (2) the effect of the plant matrix on the uptake of luteolin derivatives in Artemisia afra aqueous-extract forms across the Caco-2 cell monolayer, (3) the effect of the plant matrix on the absorption and metabolism of luteolin derivatives in Artemisia afra aqueous-extract forms in the perfused rat small intestine, (4) the effect of gut contents on the uptake and metabolism of luteolin derivatives in intestinal loop and (5) the metabolic profiles of luteolin derivatives obtained for the pure solutions versus plant aqueous extract solutions in Caco-2 cells and the rat intestine.

APA, Harvard, Vancouver, ISO, and other styles

41

Ho, Wing Yan. "Studies on molecular mechanism of action and synthesis of new derivatives of the antimalarial drug artemisinin /." View abstract or full-text, 2004. http://library.ust.hk/cgi/db/thesis.pl?CHEM%202004%20HOW.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Zhao, Can. "Mode-of-action of PAF26 and the discovery of more active and stable cyclic PAF26 derivatives." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/23637.

Full text

Abstract:

The significance of fungal infections has been grossly underestimated. Only a few drugs are clinically available to treat life-threatening fungal infections, and resistance against these drugs is rising. Antifungal peptides (AFPs) are being actively explored as novel pharmaceuticals. PAF26 is a de novo designed hexapeptide possessing N-terminal cationic and C-terminal hydrophobic regions. Previously the roles of each of these motifs in the antifungal mode-of-action of PAF26 have indicated that it involves three stages: interaction with the plasma membrane, internalisation, and cell killing. The overall aim of my project was to obtain further insights into its mode-of-action and develop more active antifungal derivatives of PAF26. Three experimental fungal systems were used in this study: the model Neurospora crassa, the human pathogen Aspergillus fumigatus and the plant/human pathogen Fusarium oxysporum. The first objective of the study was to evaluate the impact of different fluorescent labels on the intracellular localisation and antifungal properties of PAF26. For this purpose a library of PAF26 labelled with 13 different fluorophores was synthesised. This library contained PAF26 conjugates of broad chemical and spectral diversity. These fluorescent PAF26 conjugates were analysed by live-cell imaging and tested for their antifungal activities. The different fluorescent labels were found to have significant impacts both on intracellular localisation and antifungal activities. TMR, carboxyfluorescein, NBD and DMN were found to be the best labels for live-cell imaging because they had the least influence on the intracellular localisation and antifungal activity of PAF26. The second objective was to identify target proteins of PAF26 in N. crassa cells. A large number of proteins were identified as binding to PAF26 from a protein pull-down and mass spectroscopy analysis using TMR- and fluorescein-labelled PAF26. One of these proteins was the highly abundant plasma membrane ATPase PMA-1. An in-silico analysis showed that PMA-1 is likely to be a major target protein of PAF26. The final objective was to develop novel antifungals based on PAF26 with improved activities and stability. Novel cyclic derivatives of PAF26 were designed in-silico against PMA-1. These peptides were synthesised and tested against N. crassa, A. fumigatus and F. oxysporum and were found to have higher activities (at the sub-micromolar level) and greater stability than the linear PAF26. Overall this study has provided novel mechanistic insights into the mode-of-action of PAF26 and discovered novel highly active antifungal peptides with clinical potential as therapeutics.

APA, Harvard, Vancouver, ISO, and other styles

43

Gitari, Wilson Mugera. "Evaluation of the leachate chemistry and contaminants attenuation in acid mine drainage by fly ash and its derivatives." Thesis, University of the Western Cape, 2006. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_6041_1254305614.

Full text

Abstract:

This study aimed at understanding the chemistry of the neutralization of the acid mine drainage with fly ash by considering the acid mine drainage : fly ash ratios that produce neutral and alkaline process waters.

APA, Harvard, Vancouver, ISO, and other styles

44

Reeves, Katherine Ann. "The cardiovascular actions of the isopropyl ester and other synthetic derivatives of palmitoyl carnitine." Thesis, University of Bath, 1995. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260252.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Gilliam, Sarah Elizabeth. "The mode of action and therapeutic potential of purine and pyrimidine phosphonylmethoxyalkyl derivatives against bovine herpesvirus-1." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319534.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Okamoto, Hirokazu. "Development of Polyprenylazacycloalkanone Derivatives as Percutaneous Penetration Enhancers and Their Mechanism of Action Based on Diffusion Model." 京都大学 (Kyoto University), 1989. http://hdl.handle.net/2433/73144.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Juračka, Zdeněk. "Rozpoznávací metody v oblasti biosignálů." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2009. http://www.nusl.cz/ntk/nusl-217975.

Full text

Abstract:

The thesis is focused on the recognition methods study used in one-dimensional signal processing. A lot of recognition methods exist, this thesis briefly describes the principle of some of them, e.g. artificial neural networks, fuzzy systems, expert systems and decision trees. Dynamic time warping (DTW) method has been chosen for signal processing available from UBMI database. DTW can be used as a non-linear signal processing method. The result of this method is to determine the similarity of two compared signals on the basis of their distance calculation. One of the reasons for choosing this method was the possibility of various length signal processing. The principle of the method as well as the calculation of the distance between two input data sequences is described in the thesis. DTW path finding method is also mentioned. The method was applied on randomly selected numbers and a set of simulated signals. The method was applied to ECG and action potential signals recorded on the isolated rabbit heart. DTW was used to evaluate shape changes of these signals in repeated phases of the experiment known as ischemia and reperfusion. Selected cardiac cycles were detected and included into different experiment phases on the basis of calculated distance results using DTW. Sensitivity was selected as an evaluative criterion of this classification method. It reached a value of 65%. DTW algorithm was further tested on the selected cardiac cycle mapping to the corresponding minute record in the selected experiment phase. It reached a sensitivity of 68.3%. The motion artifact appearance was monitored using DTW on AP signals. The method functioned more precisely on signals measured in ischemia phases. Along with the above mentioned, the thesis discusses all aspects of heart electrical manifestation activities called as ECG signals and action potentials, such as origin, propagation, recording, post-processing and measuring out.

APA, Harvard, Vancouver, ISO, and other styles

48

Gurskaitė, Herta. "Kalio kanalų (KACh ir KATF)naujų sulfonilkarbamidinių moduliatorių įtaka širdies elketromechaniniam aktyvumui." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2007. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2007~D_20070307_101958-52348.

Full text

Abstract:

Annotation Herta Gurskaitė The title of dissertation: Effects of new sulfonylcarbamide modulators of potassium channels (KACh and KATF) on the electromechanical activity of the heart. The aim of this study was to investigate the influence of new sulfonylcarbamide modulators of potassium channels (KACh and KATP) on the electromechanical activity parameters of guinea pig myocardium and the heart rhythm. The objectives of the scientific work were as follows: 1. To estimate the influence of carbachol, an activator of the muscarinic receptor-operated KACh channels, and pinacidil, an activator of KATP channels, and their blockers (atropine and glybenclamide) on the action potential (AP) duration and contraction force in guinea pig myocardium. 2. To investigate the effect of procainamide and its new sulfonylcarbamide derivatives on the AP duration and contraction force in guinea pig myocardium under the KACh and KATP channel activation. 3. To investigate the influence of 2-, and 4-aminopyridines and their new sulfonylcarbamide derivatives as well as 2-aminopyrimidine derivatives on the AP duration and contraction force in guinea pig myocardium under the KACh and KATP channel activation. 4. To determine the anticholinergic effect of the most potent new sulfonylcarbamide derivatives on the sinus rate in isolated guinea pig heart. 5. To determine, does the anticholinergic effect of the most effective sulfonylcarbamide compound was induced via blockade of M2-receptors and/or it... [to full text]

APA, Harvard, Vancouver, ISO, and other styles

49

HENDRON, EUNAN. "Potent and specific actions of 2-Aminoethoxydiphenyl borate (2-APB) derivatives on Orai channel function." Diss., Temple University Libraries, 2013. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/235040.

Full text

Abstract:

Biochemistry
Ph.D.
In an effort to dissect the mechanism of SOCe activation, I used two novel 2-APB analogs (DPB162-AE and DPB163-AE) which are ~50-100 times more potent at modifying SOCe than 2-APB. In the presence of STIM1, both compounds (2 µM) differentially affected Orai subtypes, fully blocking endogenous Orai1, but not Orai2 or Orai3 mediated SOCe in DT40 Orai-specific knockout cells. Neither analog directly activated Orai3 over-expressed alone in HEK293 cells. Analysis of constitutively active Orai1 mutant, Orai1V102C, showed an increase in Ca2+ entry after application of DPB162-AE independent of STIM1. When STIM1 was co-expressed with Orai1V102C, there was no inhibitory effect of the analog on the mutant channel complex. DPB162-AE appeared to have a long term effect on the channel complex revealed a lack of SOCe 10 minutes after washout of the analog. STIM1ct-Orai1 Ca2+ entry was moderately increased by DPB162-AE yet constitutively active Stim1ct4EA-Orai1 Ca2+ entry was robustly inhibited. The activation of mutant Orai1V102C indicated the analogs are capable of interacting with Orai1, perhaps to widen the pore, and pointing to a putative mechanism of action for inhibition. FRET analysis indicated no effect on STIM1-Orai1, STIM1ct-Orai1 or SOAR-Orai1 coupling. Thus, the inhibitory effect on STIM1-Orai may be through physical alteration of Orai1 gating. Previously reported as having biphasic effect on SOCe proteins, DPB163-AE appeared to effect its potentiation exclusively via STIM2 with no evident inhibition of STIM2 SOCe. Inhibition by both analogs was mediated by STIM1. DPB162-AE and DPB163-AE had remarkable specificity on Orai1 as opposed to other Ca2+ permeant channels. Neither compound affected Ca2+ entry through TRPC3, TRPC6, or strontium entry through Cav1.2 channels at concentrations (2 µM) that completely inhibited Orai1-mediated SOCe. In summary, DPB162-AE and DPB163-AE are highly specific inhibitors of Orai1 SOCe, with little effect on Orai2 and Orai3, and no effect on other Ca2+ channels. They do not disrupt STIM-Orai coupling but may modify functional Orai1 channel structure to effect their inhibitory action on SOCe.
Temple University--Theses

APA, Harvard, Vancouver, ISO, and other styles

50

Obayemi, Olumide Kolawole. "Statutory derivative actions, the locus standi of a minority shareholder to enforce corporate rights in Alberta and Nigeria." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0021/MQ47127.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!