Academic literature on the topic 'Depression, oxidative stress, older adults'
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Journal articles on the topic "Depression, oxidative stress, older adults"
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Al-Rawaf, Hadeel A., Ahmad H. Alghadir, and Sami A. Gabr. "Circulating microRNAs and Molecular Oxidative Stress in Older Adults with Neuroprogression Disorders." Disease Markers 2021 (October 22, 2021): 1–10. http://dx.doi.org/10.1155/2021/4409212.
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Background. circulating microRNAs are potential blood biomarkers differentially expressed in many diseases including neuro depression disorders. It controls the expression of human genes and associated cellular and physiological processes in normal and diseased cells. We aimed to evaluate the potential role of circulating miRNAs and their association with both stress hormones and cellular oxidative stress in neuro depression disorders occurred among older adults. Methods. a total of 70 healthy subjects were included in this study. Based upon the profile of mood states (POMS-32 score), the participants classified into two groups; healthy subjects (n =30) and depression (n =40). The expression of microRNAs; miR-124, miR-34a-5p, miR-135, and miR-451-a and their correlation with cellular oxidative stress parameters; cellular NO, genes of SOD2, CAT and iNOS, and hormones; cortisol and serotonin were estimated by a quantitative real-time RT-PCR, high-performance liquid chromatography, and ELISA Immunoassay techniques, respectively. Results. depression was reported in 57.14% of the participants. The results showed a significant increase (p =0.01) in the total mood scores, and relative depression domains in older adults with depression compared to healthy controls. The relative expression levels of miR-124, miR-34a-5p significantly increased and the expression levels of miR-135, and miR-451-a significantly decreased in older adults with depression compared to healthy controls. In addition, the levels of cortisol significantly increased and serotonin (5HT) significantly reduced in all participants with depression. Cellular oxidative stress analysis for depressed subjects showed that serum NO levels and the expression of iNO gene significantly increased conversely with a decline in the molecular expression antioxidative genes; SOD2, CAT, respectively. The results showed that cellular oxidative stress parameters correlated positively with depression scores, cortisol, and negatively with cellular serotonin levels. In depressed subjects, the relative expression of microRNAs correlated positively with depression score, NO, iNOS, cortisol, and negatively associated with SOD2, CAT, and serotonin. Conclusion. The combination of cellular oxidative stress and hormonal levels strongly supports a role for circulating miRNAs; miR-124, miR-34a-5p, miR-135, and miR-451-a in the regulation of depression and mood disorders among older adults. The expressed microRNAs with their related association to cellular oxidative stress and adrenal hormones are a step towards understanding the role of these small RNA molecules in the progression of depression among older adults. Thus, cellular miRNAs might have a prognostic role in the diagnosis and as a target for treatment strategies in depressed subjects.
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Howard, Caitlin, Luigi Ferrucci, Kai Sun, Linda P. Fried, Jeremy Walston, Ravi Varadhan, Jack M. Guralnik, and Richard D. Semba. "Oxidative protein damage is associated with poor grip strength among older women living in the community." Journal of Applied Physiology 103, no. 1 (July 2007): 17–20. http://dx.doi.org/10.1152/japplphysiol.00133.2007.
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Grip strength, an indicator of muscle strength, has been shown to be a predictor of poor outcomes among older adults. Protein carbonylation, an indicator of oxidative damage to proteins, leads to cellular dysfunction and a decline in tissue function. Oxidative stress has been implicated in the pathogenesis of sarcopenia. The objective was to determine whether serum protein carbonyl concentrations are associated with grip strength in older women living in the community. A cross-sectional study was conducted in 672 women, aged 65 and older, from the Women's Health and Aging Study (WHAS) I, the one-third most disabled women residing in the community in Baltimore, MD. Protein carbonyl and grip strength were measured in each patient. In a multivariate analysis adjusting for age, race, body mass index, and Mini-Mental Status Examination score, protein carbonyls (nmol/mg) were associated with grip strength (β = −6.77, P < 0.01). The statistical association was unchanged after the analysis adjusted for hypertension, congestive heart failure, and depression. Ordered logistic regression models adjusted for the above factors showed that protein carbonyls are associated with increased odds of being in the lower quartiles of grip strength (odds ratio 8.74, 95% confidence interval 1.06–71.89, P = 0.043). These results suggest oxidative protein damage is independently associated with low grip strength among older women living in the community. Increased oxidative stress may be contributing to loss of muscle strength in older adults.
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Ramesh, Bharathi, Arlene Isseks, Jonathan Martin, Safiyah Mansoori, Annie Browne, Richard Suminski, and Sheau Chai. "Vitamin C and Copper Intake Associated With Cognitive Function in Older Adults." Current Developments in Nutrition 6, Supplement_1 (June 2022): 164. http://dx.doi.org/10.1093/cdn/nzac051.080.
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Abstract Objectives Oxidative stress has been linked to the development of depression and anxiety as well as cognitive decline in older adults. Vitamins and minerals that have antioxidant properties or serve as cofactors can improve the oxidant-antioxidant balance in the body and lead to a reduction in oxidative stress and inflammation. We aimed to study antioxidant and antioxidant cofactor intake from diet in the older population in relation to mental and cognitive health. Methods A cross-sectional study was conducted that included 181 men and women aged 60–80 years. Individuals diagnosed with dementia, Alzheimer's, or other neurological disorders were excluded. Dietary information was obtained using a 3-day diet record and food frequency questionnaire. Mental and cognitive health were assessed using Geriatric Depression Scale, Geriatric Anxiety Inventory, Montreal Cognitive Assessment (MoCA), and Digit Span test. Partial Pearson Correlation analyses were performed using SPSS software. Results Our findings indicate that vitamin B1 [r = .18, p < .05], vitamin C [r = .24, p < .001], vitamin D [r = .15, p < .05], and zinc [r = .15, p < .05] were positively correlated with Total Digit Span score, after controlling for antioxidant supplementation and other covariates such as age, education, economic status, etc. However, after further controlling for daily caloric intake, only vitamin C remained significantly associated with Total Digit Span score [r = .18, p < .05], and copper was inversely associated with MoCA scores [r = -.18, p < .05]. No other associations were found between the other variables. Conclusions Our findings suggest that higher vitamin C and lower copper intake from foods, are associated with cognitive performance among older adults. Further studies are needed to better understand the role of vitamin C and copper intake in cognitive function of older adults. Funding Sources None.
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Duffy, Shantel L., Jim Lagopoulos, Nicole Cockayne, Daniel F. Hermens, Ian B. Hickie, and Sharon L. Naismith. "Oxidative stress and depressive symptoms in older adults: A magnetic resonance spectroscopy study." Journal of Affective Disorders 180 (July 2015): 29–35. http://dx.doi.org/10.1016/j.jad.2015.03.007.
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Strath, Larissa J., Catherine D. Jones, Alan Philip George, Shannon L. Lukens, Shannon A. Morrison, Taraneh Soleymani, Julie L. Locher, Barbara A. Gower, and Robert E. Sorge. "The Effect of Low-Carbohydrate and Low-Fat Diets on Pain in Individuals with Knee Osteoarthritis." Pain Medicine 21, no. 1 (March 13, 2019): 150–60. http://dx.doi.org/10.1093/pm/pnz022.
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Abstract Objective Osteoarthritis is the most prominent form of arthritis, affecting approximately 15% of the population in the United States. Knee osteoarthritis (KOA) has become one of the leading causes of disability in older adults. Besides knee replacement, there are no curative treatments for KOA, so persistent pain is commonly treated with opioids, acetaminophen, and nonsteroidal anti-inflammatory drugs. However, these drugs have many unpleasant side effects, so there is a need for alternative forms of pain management. We sought to test the efficacy of a dietary intervention to reduce KOA. Design A randomized controlled pilot study to test the efficacy of two dietary interventions. Subjects Adults 65–75 years of age with KOA. Methods Participants were asked to follow one of two dietary interventions (low-carbohydrate [LCD], low-fat [LFD]) or continue to eat as usual (control [CTRL]) over 12 weeks. Functional pain, self-reported pain, quality of life, and depression were assessed every three weeks. Serum from before and after the diet intervention was analyzed for oxidative stress. Results Over a period of 12 weeks, the LCD reduced pain intensity and unpleasantness in some functional pain tasks, as well as self-reported pain, compared with the LFD and CTRL. The LCD also significantly reduced oxidative stress and the adipokine leptin compared with the LFD and CTRL. Reduction in oxidative stress was related to reduced functional pain. Conclusions We present evidence suggesting that oxidative stress may be related to functional pain, and lowering it through our LCD intervention could provide relief from pain and be an opioid alternative.
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Mensah, Ekow, Khalid Ali, Winston Banya, Frances Ann Kirkham, Manuela Mengozzi, Pietro Ghezzi, and Chakravarthi Rajkumar. "FRailty and Arterial stiffness – the role of oXidative stress and Inflammation (FRAXI study)." Biomarker Insights 17 (January 2022): 117727192211307. http://dx.doi.org/10.1177/11772719221130719.
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Objective: There is an association between frailty and arterial stiffness. However, arterial stiffness does not uniformly correlate with the spectrum of frailty states. Both oxidative stress and inflammaging contribute to vascular ageing. There are no human studies exploring links between arterial stiffness, oxidative stress, inflammaging and frailty. Our objective is to investigate arterial stiffness and inflammaging as predictors of frailty states. Methods: An observational longitudinal cohort study will be used to examine the association between arterial stiffness, oxidative stress and inflammation in 50 older adults (⩾70 years) with clinical frailty scores (CFS) ⩽6 over 6 months. All study measurements will be taken at baseline. Frailty assessment will include hand-grip strength, timed-up and go test, mini-mental state examination, geriatric depression scale and sarcopenia using body composition measurements with Tanita®. Arterial stiffness measurements will include carotid-femoral pulse wave velocity (cfPWV) and carotid-radial pulse wave velocity (crPWV) using Complior (Alam Medical, France). CAVI device will measure Cardio-ankle vascular index and ankle brachial index (ABI). Oxidative stress blood markers nitrotyrosine (NT) and 8-hydroxy-2’-deoxyguanosin (8-oxo-dG) and inflammation markers high-sensitive C-reactive protein (hs-CRP) and interlukin-6(IL-6) will be measured at baseline and 6 month along with lipid profile and glycated haemoglobin. Results (data analysis plan): Descriptive statistics for continuous data using means and standard deviations for normality distributed variables or medians and inter-quartile ranges for skewed variables will be used. Participants will be categorised into CFS 1-3, and CFS 4-6. Categorical data will use frequencies and comparison between groups. Change in frailty between the groups over 6 months will be compared using paired t-test. Simple linear regression will be done between frailty measures, arterial stiffness, inflammation and oxidative stress biomarkers. Significance will be at P < .05. Conclusion: This study data will inform a larger, multi-centre study exploring further the interplay between frailty, biomarkers and arterial stiffness parameters.
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Duffy, Shantel L., Loren Mowszowski, Haley LaMonica, and Sharon L. Naismith. "P1-604: PHYSICAL ACTIVITY LEVELS ARE ASSOCIATED WITH SPECTROSCOPIC MARKERS OF OXIDATIVE STRESS AND NEURONAL INTEGRITY IN OLDER ADULTS WITH MILD DEPRESSIVE SYMPTOMS." Alzheimer's & Dementia 15 (July 2019): P508. http://dx.doi.org/10.1016/j.jalz.2019.06.1209.
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Rosado-Pérez, Juana, Edelmiro Santiago-Osorio, Rocío Ortiz, Rocío Ortiz, and Víctor Manuel Mendoza-Núñez. "Tai Chi Improves Oxidative Stress in Mexican Older Adults." Free Radical Biology and Medicine 49 (January 2010): S225. http://dx.doi.org/10.1016/j.freeradbiomed.2010.10.655.
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Rosado-Pérez, J., E. Santiago-Osorio, R. Ortiz, and V. M. Mendoza-Núñez. "Tai Chi diminishes oxidative stress in Mexican older adults." Journal of nutrition, health & aging 16, no. 7 (August 2012): 642–46. http://dx.doi.org/10.1007/s12603-012-0029-9.
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Traustadóttir, Tinna, Sean S. Davies, Yali Su, Leena Choi, Holly M. Brown-Borg, L. Jackson Roberts, and S. Mitchell Harman. "Oxidative stress in older adults: effects of physical fitness." AGE 34, no. 4 (June 14, 2011): 969–82. http://dx.doi.org/10.1007/s11357-011-9277-6.
Full textDissertations / Theses on the topic "Depression, oxidative stress, older adults"
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Bartolommei, Natalia. "Oxidative stress in depressed patients over 65." Doctoral thesis, Università di Siena, 2018. http://hdl.handle.net/11365/1046748.
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Background: Depression is a common disorder in older adults (patients aged more than 65 years) that is associated with emotional suffering, increased disability, functional impairment/activity limitations and costs and negative health outcomes over time. Current research in the neuropsychiatric field is focusing no longer on a single substrate or neurotransmitter system (such as altered serotonin or catecholamine neurotransmission) but rather on integrating multiple parameters (as pro-inflammatory agents and oxidative stress), as a reflection of the physio-pathological complexity of mental disorders, seen as real neuroendocrine and systemic dysfunctions.
Aim: to evaluate the clinical status in "over-65" patients affected by depression and anxiety through psychiatric scales; to measure in these patients and control subjects, matched by gender and age, 5 parameters of oxidative stress in plasma: the Advanced products of protein oxidation (AOPP), the Ferric reducing antioxidant power (FRAP), total thiols (-R-SH), Superoxide dismutase (SOD), or anion superoxide conversion to H2O2, Catalase (CAT), or H2O2 conversion to H2O and O2; to appraise the plasma levels of 3 pro-inflammatory cytokines secreted by innate immunity, IL-6, IL-8 and TNFa in recuited patients as possible correlates of clinical symptoms and the oxidative stress biomarkers under investigation; to apply inferential statistic to assess between-groups differences as well as to
preliminarily correlate the different variables under investigation. Methods: A total of 60 subjects aged ≥ 65 years were enrolled. Elderly subjects suffering from depression were recruited during their hospitalization in a psychiatric ward (n=30). The control subjects (n=30), were matched by age and sex, among non-depressed patients, without psychiatric pathologies and in treatment for minor pathologies affecting the peripheral nervous system. All patients were evaluated with HAM-D; GDS; HAM-A; MMSE; YMRS; RFL; SSI; ADL; IADL. Each patient
underwent a fasting blood sample. Blood sample (10 ml) was collected in two tubes: a K-EDTA tube for all dosage and a lithium-heparin tube for the parameter FRAP. AOPP: spectrophotometric assay; evaluation of oxidative damage to proteins; the assay follows the protocol by Witko-Sarsat et al. (1996); the change in absorbance is measured at λ = 340 nm. Total thiols: spectrophotometric assay; rating reducing power -SH groups; The assay follows the protocol indicated by Hu in 1994.
FRAP:spectrophotometric assay; rating plasma antioxidant power; the assay follows the protocol by Benzie and Strain (1996). SOD:competitive colorimetric assay kit; rating enzyme activity.
CAT:colorimetric assay kit; rating enzyme activity. The pro-inflammatory cytokines, IL-6, IL-8 and TNF-a, were measured in plasma samples of patients by means of a same type of Immuno-enzyme ELISA assay kit.
Results: About half of the sample presented comorbidity with an anxiety disorder. The sample was composed by patients already under treatment with antidepressants, presenting two or three somatic
heath concerns and comorbidities. For what concerns the HAM-D items and the corresponding clinical
presentation, elderly depressed patients of our sample presented high scores in depressed mood -
expressed in a non-verbal way -suicide, work and interests, psychic and somatic anxiety, gastrointestinal
symptoms and somatic symptoms in general, hypochondria.
First of all, we observed a strong increase (more than +50%, on average) of an index of oxidative stress,
AOPP in depressed vs. non-depressed patients. Concurrently, we also reported a strong reduction of
antioxidant compounds in plasma, in terms of levels of Total thiols and FRAP antioxidant power.
Levels of IL6, IL8 and TNFa measured in patients fitted within values reported in other study. We
observed that both TNFa, and SOD activity, were positively correlated with AOPP protein chlorination.
Indeed, we also reported that Total thiols, were negatively correlated with SOD level. Interestingly, we
could report a negative correlation between IL8 and AOPP. We found that subjects with familiarity for
depression had lower levels of IL8 than those without familiarity.
No significant correlation between biochemical parameters and HAM-D, GDS, HAM-A rating scale
scores was found.
A negative correlation found between Total thiol and IADL score in severe depressed aged subjects was
found. Patients showing higher items for the SSI scale of suicidal ideation had respectively lower IL8
levels and higher SOD activity. CAT activity and H2O2 scavenging was instead inversely correlated
with cognitive abilities, appraised by the MINI mental state interview. Finally, a higher antioxidant
power in plasma, FRAP, was found in subjects with a higher scholar education.
Conclusion: this study show preliminary data; with the expansion of the sample size it will be
possible to obtain statistically more consistent results. We found relevant change of ROS
scavenging system in severe geriatric depression. These results are in any case a starting point
towards a deeper investigation on specific components of the inflammatory and immune response
possibly altered in different forms of depression.
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Stukenberg, Karl William. "Depression, stress, and social support among middle-aged and older adults /." The Ohio State University, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487687485811616.
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Demireva, Petya D. "Cortisol as a Potential Mediator of the Relationship between Depressive Symptoms and Memory Performance in Older Community-Dwelling Adults." Ohio University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1307570121.
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Perry, Cynthia Elizabeth. "Association Between Polymorphisms Associated with Major Depression, Cognitive Function, and Stress Regulation and Telomere Length in Older Community-Dwelling Adults and in Older Competitive Athletes." BYU ScholarsArchive, 2016. https://scholarsarchive.byu.edu/etd/6214.
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Many factors detrimental to healthy aging have been proposed including depression, stress, cognitive decline, and telomere shortening. Of specific interest are the genetic factors that may contribute to these factors and subsequently lead to accelerated telomere shortening and aging, namely the Bcl1, 5-HT, DRD2, and ApoE polymorphisms. We sought to: 1) further clarify the role of depression, stress tolerance, and cognitive decline in aging by examining the effect of associated polymorphisms (Bcl1, 5-HT, DRD2, and ApoE) on telomere length in two samples of older adults and 2) determine the difference in absolute telomere length between the two groups. We examined two samples of older adults: participants in a competitive, athletic event (N=220; mean age=66.8 years) and a sample of community-dwelling older adults (N=208; mean age=69.1 years). Participants completed a questionnaire with demographic information and provided a saliva sample. The Bcl1, 5-HT, DRD2, and ApoE polymorphisms were determined using PCR and Taqman assays. Telomere length was determined using qPCR analysis. The community-dwelling group had significantly shorter telomere lengths than the athletic group (t=-4.82, p< .0001). Additionally, for males in the athletic group, the L/S genotype of the 5-HT polymorphism was associated with longer telomere length. In males in the community-dwelling group, the GC genotype of the Bcl1 polymorphism was associated with shorter telomere length. In females in the athletic group, the GC and GG genotypes of the Bcl1 polymorphism were associated with shorter telomere length with the opposite being true for females in the community-dwelling group: the GC genotype of the Bcl1 polymorphism predicted longer telomere length. Exercising nearly everyday and the length of exercise were associated with telomere length in both groups. Our results indicate that competitive athletic activity in older age is associated with increased telomere length, longer periods of exercise at one time may contribute to longer telomere length, and the Bcl1 and 5-HT polymorphisms are associated with telomere length in older adults.
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Jodoin, Angela May. "The effect of nurse-coordinated telecare intervention on depressed mood and diabetes-related stress among community-dwelling older adults with type 2 diabetes mellitus in Southeastern Ontario." Thesis, Kingston, Ont. : [s.n.], 2007. http://hdl.handle.net/1974/501.
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Jun, Jung Sim. "Assessing the mediating role of spiritual factors on the relationship between stress and depression among older adults in assisted living facilities." Thesis, Wichita State University, 2012. http://hdl.handle.net/10057/5401.
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This study examined the relationship between stress and depression, and the mediating role of spiritual factors among 316 older adults, 65 years or older in assisted living facilities (ALFs). Hierarchical regression analysis revealed that a high level of stress was associated with a high level of depression among older residents. For male residents, a Sobel test indicated that the direct coefficient of stress on depression decreased when spiritual coping and forgiveness were mediated. However, there was no significant mediating role of spiritual factors for stress and depression among female residents. This study suggests the importance of providing spiritual support for older men who are dealing with significant stress as a way to minimize depressive symptoms.Thesis (M.S.W.)--Wichita State University, College of Liberal Arts and Sciences, Dept. of Social Work
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CARRIERI, BARBARA. "The role of nutritional factors in cognitive aging of older adults." Doctoral thesis, Università Politecnica delle Marche, 2021. http://hdl.handle.net/11566/287761.
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Nell'ultimo secolo, a grazie ai progressi compiuti dalla medicina, dalla sanità pubblica e dalle migliorate condizioni socio-economiche, la speranza di vita alla nascita è aumentata nei paesi ad alto reddito, Italia compresa, passando da 45 anni a più di 80 anni. L'invecchiamento è un fattore di rischio per malattie croniche che vengono erroneamente considerate una fase inevitabile dell'invecchiamento. L'aumento della prevalenza di queste malattie in giovane età significa che sono anche legate a uno stile di vita inadeguato. A questo proposito, la riduzione dei fattori di rischio per alcune malattie croniche può portare ad una significativa riduzione del rischio di svilupparle. La prevalenza del deterioramento cognitivo aumenta con l'età e in un terzo dei casi peggiora fino alla demenza che è una condizione altamente invalidante associata ad alti costi sanitari e sociali. Dal punto di vista della salute pubblica, è di primaria importanza cercare di prevenire o posticipare l'insorgenza del declino cognitivo e cercare di rallentare la sua progressione verso la demenza. Dato che nessun trattamento farmacologico può prevenire o ritardare il deterioramento cognitivo e la demenza, è obbligatorio cercare di intervenire su fattori di rischio modificabili, come l'alimentazione. Lo stress ossidativo sembra giocare un ruolo chiave nella patogenesi del declino cognitivo e della demenza. Obiettivo del lavoro svolto durante il dottorato di ricerca è stato indagare il ruolo di fattori nutrizionali nel declino cognitivo associato all’invecchiamento. Particolare interesse è stato rivolto a nutrienti ad azione antiossidante come vitamina E e composti polifenolici. La vitamina E, in particolare l'α-tocoferolo, è una vitamina introdotta con la dieta ad alto potenziale antiossidante. Tuttavia, ci sono evidenze contrastanti in letteratura riguardo alla sua associazione con declino cognitivo e demenza. L’attività di dottorato è stata quindi finalizzata a verificare la presenza di un'associazione tra livelli plasmatici di vitamina E e deterioramento cognitivo, nella popolazione di anziani, non dementi al basale partecipanti allo studio InCHIANTI (Invecchiare In CHIANTI), seguiti per 17 anni. I risultati ottenuti hanno confermato la presenza di un'associazione tra il livello plasmatico di vitamina E e lo stato cognitivo: l'aumento di 10 µmol / L di vitamina E è stato associato ad una ridotta HR del deterioramento cognitivo del 20%. Inoltre, la ricerca è stata rivolta ad indagare il ruolo dei composti polifenolici introdotti con l’alimentazione sulle malattie croniche che possono essere fattori di rischio per il deterioramento cognitivo. Tale attività ha portato alla pubblicazione di una revisione sistematica intitolata “Systematic Review on Polyphenol Intake and Health Outcomes: Is there Sufficient Evidence to Define a Health-Promoting Polyphenol-Rich Dietary Pattern?”. I dati ottenuti hanno riportato l'associazione inversa tra l'assunzione di polifenoli e diversi outcome di rischio per la salute e le malattie. Tuttavia, a causa dell'elevata eterogeneità degli studi, non è stato possibile definire un range raccomandato di assunzione giornaliera di polifenoli. In conclusione, i risultati ottenuti hanno confermato il ruolo della dieta come fattore di rischio di declino cognitivo. Pertanto, è possibile raccomandare una dieta ricca in antiossidanti (vitamina E e polifenoli) come strategia preventiva al fine di promuovere un invecchiamento cognitivo in salute.In the last century, due to progresses made by medicine, public health and social-economic conditions, life expectancy at birth increased in high income countries, including Italy, from 45 years to more than 80 years. Aging is a risk factor for chronic diseases which are mistakenly considered an unavoidable stage of aging. The increase in the prevalence of these diseases at a young age means that they are also related to an inadequate lifestyle. In this regard, the reduction of risk factors for certain chronic diseases can lead to a significant reduction in the risk of developing them. The prevalence of cognitive impairment increases with age, and in one third of the cases, it worsens to dementia which is a highly disabling condition associated with high healthcare and society costs. From a public health perspective, it is of primary importance to try to prevent or postpone the onset of cognitive decline and to try to slow its progression to dementia. Given that no pharmacologic treatment can prevent or delay cognitive impairment and dementia, it is mandatory try to intervene on modifiable risk factors, such as nutrition. Oxidative stress appears to play a key role in the pathogenesis of cognitive decline and dementia. The aim of the work carried out during the PhD was to investigate the role of nutritional factors in the cognitive decline associated with aging. Particular interest was addressed to nutrients with antioxidant action such as vitamin E and polyphenolic compounds. Vitamin E, in particular α-tocopherol, is a vitamin introduced with the diet with high antioxidant potential. However, there are conflicting evidences in the literature regarding its association with cognitive decline and dementia. The PhD activity was therefore aimed at verifying the presence of an association between plasma levels of vitamin E and cognitive impairment, in the older adult population, not demented at baseline, participating in the InCHIANTI study (Aging In CHIANTI area), followed for up to 17 years. Our results confirmed the presence of an association between plasma vitamin E level and cognitive status: the increase of 10 µmol / L of vitamin E was associated with a reduced HR of cognitive impairment by 20%. In addition, the research activity carried out was aimed at investigating the role of polyphenol introduced with the diet on chronic diseases that can be risk factors for cognitive impairment. This activity led to the publication of a systematic review entitled “Systematic Review on Polyphenol Intake and Health Outcomes: Is there Sufficient Evidence to Define a Health-Promoting Polyphenol-Rich Dietary Pattern?” which focuses on another important antioxidant, polyphenols, and chronic diseases which can be risk factors for cognitive impairment. In this review we reported the inverse association between polyphenols intake, and several outcomes of health and diseases risk. Because to the high heterogeneity of the studies, it was not possible to define a recommended range of daily polyphenol intake. In conclusion, the results obtained confirmed the role of diet as a risk factor for cognitive impairment. Therefore, it is possible to recommend a diet rich in antioxidants (vitamin E and polyphenols) as a preventive strategy to promote healthy cognitive aging.
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York, Jessica L. "Religiosity and Successful Aging: The Buffering Role of Religion against Normative and Traumatic Stressors in Community-Residing Older Adults." Cleveland, Ohio : Cleveland State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=csu1210871728.
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Thesis (M.A.)--Cleveland State University, 2008.Abstract. Title from PDF t.p. (viewed on July 8, 2008). Includes bibliographical references (p. 78-87). Available online via the OhioLINK ETD Center. Also available in print.
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Liao, Pihsiu, and 廖碧绣. "The Correlation Of Economic Security, Perceived Stress, Depression And Social Participation Of Older Adults." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/72869538159676113090.
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碩士南開科技大學
福祉科技與服務管理所
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Taiwan had become an aging society since 1993. According to the data of Ministry of the Interior announced in January 2012, the percentage of nationwide population aged 65 and over reached 10.94% and increases dramatically in Taiwan. How to improve the quality of life of the elderly is an important issue. In addition to health problem, economic problem is second concern of the older people in Taiwan. The study used the secondary data from Survey of Health and Living Status of the Elderly in Taiwan（TLSA）collected by Bureau of Health Promotion Department of Health in Taiwan in 2007. The purpose of the study is to investigate the correlation of economic security, mental stress, depression and social participation in Taiwan. The results showed the economic satisfaction of the elderly is different with their health and age. The economic satisfaction of the older people aged 65 to 74 years with worse health conditions is low. The economic security of the elderly is correlated with stress, depression and social participation. One of the most important factors is the impact of cost of living. To maintain good mental quality of life, preparing for the old age earlier and having a good deposit are a necessity. Older adults can live a good quality of life for the rest of their life.
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Eversley, Tiffany C. "Le potentiel antioxydant de l’alimentation tel qu'estimé par le score ORAC : une comparaison des apports des personnes âgées avec démence du type Alzheimer avec ceux des témoins sans problèmes cognitifs." Thèse, 2012. http://hdl.handle.net/1866/8489.
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Le stress oxydatif et la formation des radicaux libres sont impliqués dans plusieurs mécanismes de la mort neuronale qui caractérisent la maladie d'Alzheimer. Les antioxydants sont reconnus comme une source de protection contre le stress oxydatif et peuvent avoir un effet protecteur sur le développement de la maladie d’Alzheimer. Cette étude visait à évaluer le potentiel antioxydant, par le biais du score « oxygen radical absorbance capacity » (ORAC), de l’alimentation habituelle de personnes âgées atteintes de la maladie d’Alzheimer en comparaison avec des témoins appariés pour l’âge sans problèmes cognitifs. L’hypothèse stipulait que les patients atteints de la maladie d’Alzheimer ont une alimentation dont le potentiel antioxydant est inférieur à celui des témoins sans problèmes cognitifs. L’étude a consisté en des analyses secondaires de données provenant de l’étude « Nutrition-Mémoire » (NMS), durant laquelle quarante-deux patients avec une démence du type Alzheimer (DTA) probable et leurs aidants étaient suivis pendant une période de dix-huit mois. Pour la présente étude, les données provenaient de trois jours de collecte alimentaire, ont été colligées au début (T0) de l’étude NMS, selon la méthode « Multiple-Pass ». Le potentiel antioxydant de l’alimentation a été déterminé à l’aide de la description des aliments énumérés dans la base de données des valeurs ORAC de l’USDA. Les résultats de l’étude ont montré que les patients avaient une alimentation dont le potentiel antioxydant était inférieur à celui des témoins (13784,07 ± 7372,70 μmol TE/100g contre 23220,54 ± 10862,55 μmol TE/100g, patients et témoins, respectivement; p<0,0001). Les analyses de régression hiérarchique pas à pas montraient que l’IMC, l’éducation, et le groupe (patients, témoins) étaient des facteurs influençant le score ORAC total. La consommation des aliments riches en antioxydants est un comportement préventif à faible risque qui pourrait bénéficier des individus susceptibles de développer la maladie d'Alzheimer.Oxidative stress and the formation of free radicals are involved in several mechanisms of neuronal death that are characteristic of Alzheimer's disease. Antioxidants are known to help defend against oxidative stress and may protect against the development of Alzheimer's disease. This study aims to evaluate the antioxidant potential, using the “oxygen radical absorbance capacity” (ORAC) score of the diet of older adults people with Alzheimer's disease compared with cognitively-intact age-matched controls. It was hypothesized that the antioxidant potential of the diet of elderly people with Alzheimer's disease will be lower than that of controls without cognitive problems. The current study is a secondary analysis of data obtained from the "Nutrition-Memory study" (NMS). The NMS study recruited forty-two patients with probable Alzheimer’s disease, and their caregivers, and followed them over a period of eighteen months. The current study focuses on three days of dietary data collection, compiled at the beginning (T0) of the NMS study. The antioxidant potential of the diet was determined using the list of ORAC scores highlighted in the USDA database for the oxygen radical absorbance capacity of selected foods. Our results showed that the diet of patients (13784.07 ± 7372.70 μmol TE/100g) had a lower antioxidant potential than that of controls (± 23220.54 10862.55 μmol TE/100g). Moreover, BMI, education and group-status were factors that influenced the total ORAC score. Eating foods rich in antioxidants is a low risk preventative behaviour that could benefit individuals susceptible to developing Alzheimer’s disease.
Books on the topic "Depression, oxidative stress, older adults"
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Kropf, Nancy P., and Sherry M. Cummings. Future Directions in Interventions with Older Adults. Oxford University Press, 2017. http://dx.doi.org/10.1093/acprof:oso/9780190214623.003.0014.
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In looking toward the future, additional treatment approaches need to be implemented and evaluated for the older population. This chapter critically examines two interventions that have demonstrated effectiveness with adults, but that have limited implementation and evaluation with older adults. These two approaches, mindfulness-based stress reduction and behavior activation, are presented as emerging therapies that hold promise for older adults in critical areas of later life such as depression, pain management, and decreasing social isolation. The literature on effectiveness with the non-aging population is summarized, and the existing studies with older adults are presented. In addition, modifications that are appropriate for older clients are included.
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Kropf, Nancy P., and Sherry M. Cummings. Problem-Solving Therapy. Oxford University Press, 2017. http://dx.doi.org/10.1093/acprof:oso/9780190214623.003.0005.
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Problem-solving therapy (PST) is a psychosocial intervention that teaches clients to cope with the stress of “here-and-now” problems in order to reduce negative health and mental health outcomes. In this chapter, the six stages of PST—problem orientation, problem definition, solution generation, decision-making, solution implementation, and outcome evaluation—are explained and exemplified via vignettes. Areas for which problem-solving therapy has been found useful are summarized, including depression, anxiety, relationship difficulties, and distress related to medical problems such as cancer and diabetes. The chapter describes contexts for practice, including primary care and home care, as well as adaptations for the use of PST with older adults. Finally, a case example of a problem-solving intervention with an unemployed depressed older man is presented to illustrate this approach.
Book chapters on the topic "Depression, oxidative stress, older adults"
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Carmeli, E., A. Bachar, O. Rom, and D. Aizenbud. "Oxidative Stress and Nitric Oxide in Sedentary Older Adults with Intellectual and Developmental Disabilities." In Advances in Experimental Medicine and Biology, 21–27. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/5584_2015_166.
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Bryant, Christina. "Psychological Interventions for Older Adults: Evidence-Based Treatments for Depression, Anxiety, and Carer Stress." In Mental Health and Illness Worldwide, 1–34. Singapore: Springer Singapore, 2016. http://dx.doi.org/10.1007/978-981-10-0370-7_21-1.
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Bryant, Christina. "Psychological Interventions for Older Adults: Evidence-Based Treatments for Depression, Anxiety, and Carer Stress." In Mental Health and Illness Worldwide, 481–514. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-2414-6_21.
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Disch, William B., Jean J. Schensul, Kim E. Radda, and Julie T. Robison. "Perceived Environmental Stress, Depression, and Quality of Life in Older, Low Income, Minority Urban Adults." In Social Indicators Research Series, 151–65. Dordrecht: Springer Netherlands, 2007. http://dx.doi.org/10.1007/978-1-4020-5682-6_9.
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Steffen, Ann M., Larry W. Thompson, and Dolores Gallagher-Thompson. "Module 8: Skills for Caregiving: Reducing Stress While Helping Others." In Treating Later-Life Depression, edited by Ann M. Steffen, Larry W. Thompson, and Dolores Gallagher-Thompson, 231–54. Oxford University Press, 2021. http://dx.doi.org/10.1093/med-psych/9780190068431.003.0014.
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Depression—at the clinical or subsyndromal level—is a commonly reported outcome of informal caregiving (e.g., for parents, partners, grandchildren, disabled children, other members of chosen family). This chapter guides providers as they help middle-aged and older adults who experience caregiver burden. The material supports psychoeducation and the clinical tasks of self-compassion, coping with caregiving stressors, problem solving, cognitive reappraisal, planning positive activities with the care recipient, and self-care. This chapter also describes the Practice forms provided in the workbook for aging clients’ use between psychotherapy and integrated primary care sessions to remember and use these skills. Clinicians are directed to apply recommended strategies that are responsive to the needs of culturally diverse aging clients, including within the context of telehealth.
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C.G. Lely, Jeannette, and Rolf J. Kleber. "Treating Trauma-related Disorders in Later Life: Moving Forward." In Stress Related Disorders [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.102499.
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Among stress-related disorders, post-traumatic stress disorder (PTSD) takes a central position. Although the percentage of older adults suffering from this condition appears to be lower than among younger adults, PTSD among them often presents a serious condition with high comorbidity rates. In this contribution, recent insights into post-traumatic stress disorder among older people as well as psychotherapeutic treatments are discussed. In particular, the results of recently completed investigations are discussed. In this research, treatment outcomes of two psychotherapeutic approaches considered suitable for older PTSD patients (Narrative Exposure Therapy or NET and Present Centered Therapy or PCT) were compared in terms of psychopathology and psychosocial adjustment. For older patients suffering from PTSD with varying backgrounds, both NET and PCT showed the potential for a significant reduction of symptoms (PTSD, depression and subjective distress). Moreover, it was found that older adults can change long-standing beliefs, even after long-past childhood trauma. In a patient’s own words: “I am still here, the past didn’t bring me to my knees”. These findings disconfirm unfounded pessimism regarding psychotherapy in later life. Currently available treatment approaches in later life can be meaningful in improving the quality of life in older adults for years to come.
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Marzetti, Emanuele, Francesco Landi, Francesca Martini, Christiaan Leeuwenburgh, and Riccardo Calvani. "Mitochondrial decline and chronic conditions of older adults." In Oxford Textbook of Geriatric Medicine, 337–44. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198701590.003.0046.
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Ageing involves a progressive deterioration of physiological integrity which leads to increased vulnerability to stressors and multisystemic functional decline. Mitochondrial dysfunction is increasingly recognized as a common denominator of ageing and an important causative factor for major age-related conditions. Mitochondrial function becomes perturbed by age-associated accumulation of mtDNA mutations, altered mitochondriogenesis and dynamics, and abnormal regulation of mitophagy. These alterations result in diminished bioenergetic efficacy, enhanced oxidative stress, and eventually loss of cellular viability. This series of events is proposed to be a major mechanism in the ageing process and the development of chronic diseases. This chapter provides an overview on the mechanisms believed to underlie the loss of mitochondrial function with ageing. Special attention is paid to the consequences of mitochondrial dysfunction in postmitotic tissues (i.e. heart, skeletal muscle, and central nervous system), where mitochondrial damage is proposed to be responsible for the appearance of age- and disease-associated phenotypes.
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Whittaker, Anna C., Jane Upton, Niharika Arora Duggal, Chadni Deb, Charanjit Randhawa, Jan Oyebode, and Janet Lord. "Understanding immunesenescence." In The New Dynamics of Ageing Volume 2, 107–30. Policy Press, 2018. http://dx.doi.org/10.1332/policypress/9781447314783.003.0007.
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This chapter discusses the impact of hip fracture in older age and in particular factors affecting recovery of physical function and wellbeing. It focuses particularly on a study of the impact of depression following hip fracture in older adults, and the influence of this depression on a range of outcomes including immune function, stress hormones, illness perceptions, physical function, and length of stay in health service and rehabilitation facilities. It shows that depression is common following hip fracture among older people, and is the biggest predictor of a slower recovery and poorer function in terms of immunity, wellbeing and physical ability. A pilot study associated with this research showed that illness perceptions following hip fracture did not differ between UK and Punjabi older adults, but that Punjabi speakers in India had greater levels of distress. Implications for health service policy and practice resulting from this research are discussed in this chapter, including potential intervention strategies to improve outcomes after hip fracture.
Conference papers on the topic "Depression, oxidative stress, older adults"
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Silva, Fernanda, Maria Jesus, Breno Barbosa, Sonia Brucki, Ricardo Nitrini, and Juliana Souza Talarico. "MENTAL HEALTH, SOCIAL CONNECTEDNESS AND COGNITIVE PERFORMANCE OF OLDER ADULTS DURING COVID-19 PANDEMIC." In XIII Meeting of Researchers on Alzheimer's Disease and Related Disorders. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1980-5764.rpda088.
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Background: Social distancing measures related to COVID-19 pandemic have challenged older adults’ social connectedness and mental health. Loneliness and social isolation have been reported, but their impact on cognition is unclear. Objective: To explore changes on daily activity, mental health and its relationship with cognitive performance in older adults during the pandemic. Methods: 100 individuals ≥60 years, without cognitive impairment, enrolled in the Brazilian Memory Study(BRAMS), were applied the UCLA Loneliness Scale, Perceived Stress Scale, Geriatric Depression Scale, Mini-Mental State Exam(MMSE), assessment of daily routine, memory complaints and social connectedness during the pandemic. Results: Almost half of the participants reported the pandemic significantly affected their life, 38.9% lost a relative due to COVID-19, 60% had daily routine changes, due to decreases in physical activity(78%), relationships(40.5%), emotion(22%) and autonomy. Voice message to keep social connectedness increased from 24.2% to 42.1% and memory complaints reached 40%. More than 30% felt more stress, loneliness or depression comparing to prepandemic. Controlling for age, sex, and education, higher UCLA scores were associated with low MMSE (p=0.018). Conclusion: COVID-19 pandemic impacted routine, social connectedness, and mental health in older adults. Loneliness was associated with lower cognitive performance, highlighting the importance of incorporating systematic evaluations into clinical practice to identify vulnerable individuals to mental and cognitive disorders during the pandemic.
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Zilidou, Vasiliki, and Panagiotis Bamidis. "EXERGAMING AND EXERDANCING ENHANCE THE WELL-BEING OF OLDER ADULTS." In INTERNATIONAL SCIENTIFIC CONGRESS “APPLIED SPORTS SCIENCES”. Scientific Publishing House NSA Press, 2022. http://dx.doi.org/10.37393/icass2022/59.
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ABSTRACT The digital age and advances in technology are introducing a new attitude to medical care, bringing about significant technologies such as exergames, enhancing the promotion of active and healthy aging. This study aimed to investigate possible differences in perceived quality of life factors between older adults participating in traditional dance and physical training using new technologies, comparing them with sedentary people (control group). The study involved 84 women, with an average age of 67.6 years from Day Care Centers of the Municipality of Thessaloniki, Greece. The program duration was six months (24 weeks) with a frequency of twice a week and each session lasted 75 minutes. An evaluation was performed both before and after the end of the interventions with specialized tools that assess the physical status and functional capacity of the individuals, as well as questionnaires that assess the quality of life indicators. Regarding the usability of the systems, integrated the System Usability Scale (SUS). Statistical analysis was performed with the statistical package SPSS 26. According to the results, the intervention groups compared to the initial measurement showed a statistically significant improvement in variables that assess strength, balance, aerobic capacity, gait to avoid falls, stress, depression, and quality of life in general, in comparison with the control group (p ≤ .05). The SUS scores ranged around 80 for both systems, so it seems that the practical implementation of the programs has the potential to provide the expected results. In conclusion, these innovative technological solutions in collaboration with expert health professionals, can improve the quality of life of older adults, remain autonomous and independent, but at the same time active members of society for a long time.
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Tunurrohmin, Zela. "Application of Precede Proceed Model on Factors Affecting Depression Symptom in the Elderly: Evidence from Surakarta, Central Java." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.01.44.
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ABSTRACT Background: Geriatric depression is a mental and emotional disorder affecting older adults. Social support is an important factor known to moderate the deleterious effects of stress in elderly. This study aimed to determine factors affecting depression symptom in the elderly using PRECEDE PROCEED model. Subjects and Method: A cross sectional study was conducted in Surakarta, Central Java. A sample of 200 elderly was selected for this study by cluster random sampling. The dependent variable was depression. The independent variables were gender, marital status, residence, education, family support, and peer support. The data were collected by questionnaire and analyzed by a multiple linear regression run on Stata 13. Results: The risk of depression in elderly increased with female (b= 5.53; 95% CI= 3.38 to 7.70; p<0.001), unmarried (b= 4.15; 95% CI=1.36 to 6.95; p= 0.004), and living at nursing home (b= 8.16; 95% CI= 5.26 to 11.06; p<0.001). The risk of depression decreased with high education (b= -5.51; 95% CI= -7.49 to -3.51; p<0.001), strong peer support (b= -2.75; 95% CI= -4.92 to -0.58; p= 0.013), and strong family support (b= -5.02; 95% CI= -7.96 to -2.09; p<0.001). Conclusion: The risk of depression in elderly increases with female, unmarried, and living at nursing home. The risk of depression decreases with high education, strong peer support, and strong family support. Keywords: depression, elderly Correspondence: Zela Tunurrohmin. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Email: ze.zelatunurrohmin@gmail.com. Mobile: 082225442002. DOI: https://doi.org/10.26911/the7thicph.01.44
Reports on the topic "Depression, oxidative stress, older adults"
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Mateș, Letiția, Marius Emil Rusu, Ionel Fizeșan, Daniela-Saveta Popa, and Daniel Leucuța. Walnut intake interventions targeting biomarkers of metabolic syndrome and inflammation in middle-aged and older adults: a systematic review and meta-analysis of randomized controlled trials research protocol. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, June 2022. http://dx.doi.org/10.37766/inplasy2022.6.0058.
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Review question / Objective: The aim of this study was to conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) in order to properly examine the evidence on the effects of walnut consumption on chosen indicators of inflammation and metabolic syndrome in mature adults. Condition being studied: Metabolic syndrome (MetS), chronic, low-grade inflammation, and oxidative stress are all important risk factors for morbidity and death, with a higher frequency in the elderly population. Information sources: We conducted a comprehensive search in five databases: Pubmed, EMBASE, Scopus, Cochrane, ClinicalTrials, from inception.