Dissertations / Theses on the topic 'Dentine – Physiologie'
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Marchand, Élodie. "Etude des modifications post-mortem de la phase minérale la dentine sclérotique." Electronic Thesis or Diss., Université de Lille (2022-....), 2023. http://www.theses.fr/2023ULILS056.
Introduction: in forensics fields, the identification of human remains is a recurrent problem. Estimating age at death is one of the criteria to be evaluated. In adults, the height of root dentin transparency is used. However, in archaeological material, this phenomenon appears to be inconsistent and related to changes in the appearance of sclerotic dentine. The aim of this study was to observe the changes in sclerotic dentin at different post-mortem intervals, focusing on the mineral part, which is the main component of this tissue and is likely to have more marked variations over longer post-mortem periods.Material and Method: The study included two parts (retrospective and prospective) with 21 monoradicular human teeth, three dating frome the 18th century from archaeological excavations and eighteen from donations of the body to science from the Faculty of Medicine of the University of Lille preserved in equivalent conditions and analyzed at different post-mortem intervals of 0, 1, 2 and 5 years. After resin embedding, the teeth were sectioned and polished, then analyzed by scanning electron microscope, completed by semi-quantitative analysis of calcium and phosphorus using EDS-X microanalysis, as well as broad detection of elements from the periodic table. We then carried out a crystallographic analysis using X-ray diffractometry.Results: The analysis showed the existence of tubular, chemical and crystallographic changes in the sclerotic dentin as a function of the post-mortem interval. Our scanning electron microscope study revealed a difference in the appearance of the tubules linked to an increase post-mortem interval: loss of the peritubular collar and obstruction of the tubule lumen by a hyperdense material. Microanalysis highlighted variations in phosphocalcic ratios among the different groups, notably at the cementum junction and more specifically in the canine, which could be a good predictive model for assessing post-mortem interval. Using diffractometry, we confirmed that the mineral phase of sclerotic dentin, whatever the post-mortem interval, was composed of hydroxyapatite crystals, with a better level of crystallinity in archaeological teeth compared with teeth with a 5-year post-mortem interval, but also between teeth with a 0 and 1 year post-mortem interval, compared with 2 years. Discussion: the differences observed could be due to post-mortem changes of the mineral phase of sclerotic dentin through demineralization and remineralization phenomena, resulting in variations in the size of hydroxyapatite crystals located in the intra-tubular zone and through the substitution of calcium by other elements, under the influence of chemical and/or bacterial action and therefore an influence of the tooth's environment (buccal and external). This work needs to be pursued, on the one hand by using imaging techniques that combine structural, chemical and crystallographic studies, such as transmission electron microscopy, and on the other hand by studying changes in collagen and non-collagenous proteins making mineral components more accessible to external factors. It would also be relevant to carry out analyses on teeth from post-mortem intervals of decades
Guignes, Philippe. "Contribution à l'étude de la perméabilité de la dentine radiculaire. Relation avec les traitements endodontiques." Toulouse 3, 1993. http://www.theses.fr/1993TOU30048.
Chmilewsky, Fanny. "Interactions entre cellules progénitrices et fibroblastes au cours de la régénération pulpo-dentinaire : rôle de l'activation du système du complémént." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM5300.
After tissue injury or infection, Complement activation provides powerful signals initiating the inflammatory reaction. These events are mediated by biologically active fragments such as C5a which attracts cells expressing its receptor (C5aR/CD88) to the injury site. Besides inflammatory cells as the main C5aR-Expressing cells, various tissue cells have been reported to express this receptor suggesting its involvement in other processes. In order to investigate the possible relationship between complement activation and pulp regeneration, we investigated Complement activation in the dental pulp and progenitor cell migration from their perivascular niches to the pulp injury site to initiate the regeneration process.Our results indicate that complement activation in the dental pulp is the result of both plasma and fibroblast secreted complement proteins. Thus upon local complement activation, which can occur after pathological injury or biomaterials application, C5a induces pulp progenitors’ migration which is critical in initiating the regenerative processes. To our knowledge, this is the first work to demonstrate the involvement of C5a biologically active fragment in the recruitment human pulp progenitor cells. This may provide a useful future therapeutic tool in targeting the progenitor cells in a dentin/pulp regeneration process
Mahdee, Anas Falah. "Physiology and pathophysiology of the dentine-pulp complex in response to dentine exposure." Thesis, University of Newcastle upon Tyne, 2017. http://hdl.handle.net/10443/3936.
FREISMUTH, ETIENNE, and DANCELME SANDRINE FREISMUTH. "Physiologie, pathologie, therapeutique bucco-dentaire du vieillard." Nancy 1, 1987. http://www.theses.fr/1987NAN13081.
Balland, Véronique. "Histoire du fluor : decouverte, physiologie, utilisation en art dentaire." Strasbourg 1, 1988. http://www.theses.fr/1988STR1D059.
CAUBET, CHRISTOPHE. "Abrasion dentaire physiologique et pathologique : etude dans une usine d'abrasifs." Toulouse 3, 1989. http://www.theses.fr/1989TOU31204.
SOLASSOL, RUFFEL MARIE-HELENE. "Contribution a l'etude de la physiologie du polynucleaire creviculaire." Toulouse 3, 1991. http://www.theses.fr/1991TOU35002.
Rotenberg, Maxime. "Modélisation de la forme d'arcade dentaire de jeunes adultes." Toulouse 3, 1996. http://www.theses.fr/1996TOU30012.
Jacques, Jaime. "Les protéines de la matrice amélaire dans un contexte physiologique." Paris 7, 2013. http://www.theses.fr/2013PA077273.
For years, amelogenin, ameloblastin and enamelin have been considered as exclusive of the dental enamel, both structural and regulating biomineralization of this tissue. This work investigates these three proteins and their transcripts through descriptive and quantitative analyses in different hard and soft tissues taking as reference the enamel organ. We establish the ontogenetic pattern bf expression of these molecules using control and amelogenin knock-out mice of different ages. We confirm the expression of these molecules in non-dental tissues. Given their chemical state, their distribution and quantity, we suggest these " enamel related proteins" as proteins with a double rote: a structural rote in enamel but also as signaling molecute, with growth factor-like functions. They would indeed participate in the regulation of the metabolism of dentoatveotar complex. Additionaly, our data suggest that the various skeletal tissues can be characterized by the expression profile of these proteins, which may represent specific markers of neural-crest derived bones
Guidet, Anne. "Contribution à l'étude physio-pathologique du fluor." Toulouse 3, 1986. http://www.theses.fr/1986TOU33026.
Somogyi-Ganss, Eszter. "Novel non-collagenous modulators of biomineralization in bone and dentin /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-101-6/.
Hinard-Bocquel, Maryvonne. "Recherche sur l'association causale entre une possibilité d'acidose hyperchlorémique due au sel marin et la carie dentaire chez les gens de mer." Paris 7, 1985. http://www.theses.fr/1985PA07F063.
Amiache, Sophie. "Etat bucco-dentaire et performances sportives." Paris 5, 1991. http://www.theses.fr/1991PA05P007.
Weiszfeld, Georges. "L'usure occlusale : approche previsionnelle tribologique." Paris 5, 1990. http://www.theses.fr/1990PA05M195.
Collins, Stuart A. "3,4-methylenedioxy-methamphetamine(MDMA)-induced Increases in Hippocampal Glutamate Concentrations and Its Impact on the Dentate Gyrus." University of Toledo Health Science Campus / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=mco1438598527.
Djolé, Stéphane Xavier. "Analyse de la biodiversité cellulaire de l'ectomésenchyme pulpaire et du rôle propre de Msx2 lors du développement et de la réparation dentinaire." Paris 7, 2014. http://www.theses.fr/2014PA077250.
Odontoblast is the dental cell which responsible to dentine secretion. Msx2 gene invalidation induces defects in dentinogenesis process. Indeed, mice lacking the homeobox gene exhibited a root dysmorphology associated to odontoblast embedded within an "osteodentin", normally noticeable in the reparative process. This work shows the impact of Msx2 in the ectomesenchymal cells fate during the postnatal dentinogenesis. Sclerostin, product of the sostdcl gene and expressed by osteocytes, is known as key regulator of differentiation in osteogenesis by inhibiting Wnt/β-catenin pathway. Analysis of the two cell marker's common to both odontogenesis and osteogenesis support the existence of cellular biodiversity in dental pulp according crown and root compartment. The model for pulp healing permit to complete the first investigations on several cell contingents in dental pulp, depend upon molecular expressions profiles. Our investigations characterize two "sub-tissues" in the pulpal ectomesenchyme, a concept which the ultimate goal is to adapt to clinical practice through a research applied for vital pulp-therapy
Oliary, Juliette. "Pénétration salivaire des antiinfectieux. Une application à l'étude du fluconazole." Paris 5, 1990. http://www.theses.fr/1990PA05P066.
GAMBAROTTA, JEAN. "Contribution a l'etude de l'usure des dents posterieures : applications a la paleontologie humaine et a la cinematique mandibulaire." Paris 7, 1996. http://www.theses.fr/1996PA07GE01.
Hunt, Robert F. III. "LOCAL SYNAPTIC NETWORK INTERACTIONS IN THE DENTATE GYRUS OF A CORTICAL CONTUSION MODEL OF POSTTRAUMATIC EPILEPSY." UKnowledge, 2010. http://uknowledge.uky.edu/gradschool_diss/94.
Caucanas, Marie-Claude Arquier. "Etude vidéo-informatique de la fiabilité de la déglutition utilisée dans la recherche de la dimension verticale d'occlusion." Toulouse 3, 1994. http://www.theses.fr/1994TOU30180.
Anderson, Ross William. "Subthreshold Oscillations and Persistent Activity Modulate Spike Output in the Rodent Dentate Gyrus." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1415229722.
Mello, Gilbert de. "La biominéralisation du bourgeon dentaire : Étude in vitro de la vitamine D et des sels minéraux dans l'odontogénèse chez la souris albinos suisse." Rennes 1, 1996. http://www.theses.fr/1996REN1A003.
Elseedy, Heba. "Rôle du réseau supramammillaire-gyrus dentelé en condition physiologique et dans les épilepsies du lobe temporal : une approche génétique." Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0113.
Mesial temporal lobe epilepsies are among the most common clinical forms of drug-resistant partial epilepsies in adults. These epilepsies are characterized by the occurrence of spontaneous recurrent seizures associated with excessive and hypersynchronous discharges of neuronal populations generated by a multi-structural epileptogenic zone involving several regions of the limbic system. The Supramammillary nucleus (SuM) is innervating all limbic cortex. In rat, it has been shown to be involved in the control of hippocampal theta rhythms and associated functions such as REM sleep as well as emotional learning and memory. More recently, it was shown that the projections from neurons of lateral region of the SuM (SuML) that innervate the dorsal dentate gyrus (DG) display a unique GABAergic and Glutamatergic neurotransmitter phenotype and this pathway is reorganized in epileptic animals. In this thesis,we demonstrated that: All the neurons from the SuML innervating the dDG co-express markers for both GABAergic and glutamatergic neurotransmissions. Activation of this pathway increases theta power and frequency as well as gamma power during REM sleep and induced net firing of some GCs. The population of GABA/GLU SuML neurons innervating the dDG is heterogeneous. Among these neurons 70% contain calretinin whereas 30% do not. In epileptic mice the SuML-dDG pathway is reorganized . Our preliminary results using in vivo optogenetic show that activation or inactivation of this pathway do not modify the seizure duration. However, this pathway modulates the variability of the seizure frequency content
Toll, Andrea Lee. "Racemization of Amino Acids in Teeth for the Determination of Age." TopSCHOLAR®, 2012. http://digitalcommons.wku.edu/theses/1144.
Raoul, Gwénaël. "Plasticité du masseter humain : relation entre les chaînes lourdes de myosine et la dysmorphose dento-maxillo-faciale." Thesis, Lille 1, 2008. http://www.theses.fr/2008LIL10124/document.
Masseter biopsies (161left, 36 right).were performed on 161 subjects undergoing surgical treatment of malocclusion. Patients were classified according to computer-assisted Delaire cephalometric analysis. The 36 patients with both side biopsies were separated into 2 groups: with or without lateral deviation. SDS-PAGE was performed on 28 biopsies to identify myosin heavy chain content. Immunostaining with myosin-isoform-specific antibodies was performed on 197 biopsies to identify 4 fiber types (l, Hybrid, II, NéoAtrial). For each fiber type, percent occupancy and mean area were calculated. Student and Wilcoxon tests were used to compare electrophoresis and immunostaining results from 28 cases, and fibre type compositions on the two sides in 36 patients. An ANOVA test was done to identify correlation between percent occupancy and mean area of each fiber type versus cephalometric classification for aIl 161 left samples. Electrophoresis and immunostaining analysis of slow and fast (lIa & IIx) myosin heavy chains gave equivalent results. Lateral deviation patients showed an increase of type II fiber occupancy (p=0,0286) on the same side as the deviation (short side). Deep bite is associated with an increase of type II fiber occupancy (p=0,0073) and decrease of NeoAtrial mean fiber area (p=0,0401). Class II is significantly associated with an increase in occupancy of hybrid fibers (p=0,0419) and decrease of type II (p=O,0234) as compared with Class Ill. Mandibular position in relation to the skull base trend is associated with an increase of percent occupancy (p=0,0023) and mean area (p=0,0387) of hybrid fibers in case both forward and backward position. CONCLUSION Facial vertical dimension and mandibular lateral deviation is significantly linked to type II fiber percentage occupancy and NeoAtrial mean fiber area. Saggital mandibular position is linked to mean fiber area and percent of hybrid fibers, and percent occupancy of type II fibers
Viale-Garrone, Audrey. "Période de la ménopause, état de santé orale et facteurs systémiques." Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM5028/document.
In a cross-sectional study of 202 postmenopausal and premenopausal women,the objectives of this study are to demonstrate a link between menopause and altered state of oral health.To evaluate the action of HRT on dental disease and finally on the tooth mortality. To assess and clarify the relationship between oral health and various general diseases and links between psyche and soma in postmenopausal women.Also discussed was the influence of bisphosphonates on the state of periodontal health.Finally,it was decided to place the study links oral menopausal status in a social and anthropological perspective.It appears then that menopause results in an altered state of oral health,(p = 0.003).HRT has a beneficial effect on the periodontal disease.The biological effects of diabetes are related to dental mortality (p = 0.050). This study emphasize the influence "per se" a bad oral health status for coronary artery disease (OR = 1.214).In postmenopausal women, stressful events, dry mouth, joint and bone diseases, hormonal deficiency are factors variously related dental mortality during this period. Moreover, it was found that women who have recently been treated for breast cancer developed more dental caries (p = 0.031 OR = 2.161).The study related the effects of bisphosphonates on the alteration of periodontal (p = 0.011), despite taking HRT (p = 0.020).In addition,background socio-economic favored contribute to the medicalization of physiological phenomenon. The fact of living alone would affect the loss of dental organs (p = 0.035). Finally, the regular practice of a sport improve the state of oral health (p = 0.036)
Beaumont, Julia, and Janet Montgomery. "A closer examination of childhood diet and physiology using stable isotope analysis of incremental human dentine." 2014. http://hdl.handle.net/10454/10425.
Abstract: The reconstruction of the diet of past populations using the stable isotope analysis of bone collagen has become a well-established tool for examining their lifeways. For example, variations in foods ingested can demonstrate differences in the foods available to individuals of different sex, age, status and in some cases identifying migrants. However, because of the remodelling of bone throughout life, this produces average values which have been incorporated in the tissues over a period of time and gives a blurred picture of the diet. The analysis of the stable isotope ratios of carbon (δ13C) and nitrogen (δ15N) from tiny increments of dentine utilizes tissue that does not remodel and that permits comparison, at the same age, of those who survived infancy with those who did not at high temporal resolution. Here, we present a study of teeth from a Great Famine period workhouse cemetery in Kilkenny, Ireland, and a contemporary 19th-century cemetery in London, England and compare these with published data from early Neolithic individuals from Sumburgh, Shetland, Scotland. Covariation in δ13C and δ15N values suggests that even small variations have a physiological basis. We show that high-resolution intra-dentine isotope profiles can pinpoint shortduration events such as dietary change, and in the historical populations these can be related to known periods of nutritional deprivation in the juvenile years of life. We further suggest that the data from the Famine cemetery individuals suggest a physiological marker within these isotope profiles for a period of nutritional deprivation which could be utilised in other periods and geographical areas, particularly where there is a catastrophic cemetery assemblage with no known aetiology. This technique could also have applications in a forensic setting.
"Synaptic and epileptiform activity of the dentate gyrus in kainate-treated rats with mossy fiber sprouting." Tulane University, 1990.
acase@tulane.edu
Tannenholz, Lindsay Elsa. "The Impact of Modulating the Activity of Adult-born Hippocampal Neurons on Neurogenesis and Behavior." Thesis, 2016. https://doi.org/10.7916/D8CN73Q9.
Algarni, Amnah Abdullah A. 1983. "Interaction between tin/flouride-containing solutions and artificially created dental pellicles on erosion prevetion in vitro." Thesis, 2013. http://hdl.handle.net/1805/3717.
BACKGROUND: Fluoride and stannous ions have been reported to be relevant for dental erosion prevention. However, their interaction with the acquired dental pellicle (ADP), a clinically relevant erosion protective factor, is not well known and needs to be investigated. OBJECTIVES: To investigate the anti-erosive properties of fluoride-containing solutions and stannous solutions on enamel and dentin surfaces with a previously formed ADP. To characterize the protein profile of the ADP treated with the test solutions. METHODS: Phase I tested four solutions: SnCl2/NaF, NaF, SnCl2 and deionized water (DIW) (as negative control). Forty bovine enamel and dentin specimens 104 (4x4x2 mm3) were prepared and randomly distributed into 4 groups (n = 10). The specimens were incubated in clarified human saliva (CHS) for 24 h for pellicle formation and then they were subjected to a cycling procedure that included a 5-min erosive challenge (0.3-percent citric acid, pH 2.6); a 2-min treatment with the solution (between 1st, 3rd and 6th cycles); a 2-h immersion in CHS, and overnight immersion in CHS. Cycles were repeated 6x/day for 5 days. The outcome measure was surface loss (SL) using profilometry. Phase II: Thirty-two (32) bovine enamel specimens (882 mm3) (n = 8) were similarly prepared and incubated in saliva for 24 h and then treated with the solutions for 2 min followed by CHS immersion for 2 h. This cycle was repeated 3x for one day. The pellicles formed and treated with the test rinse solutions were collected, digested, and analyzed for specific protein content using liquid chromatography electrospray ionization tandem mass spectrometry (LCESI-MS/MS). RESULTS: Phase I: for enamel, SnCl2/NaF, SnCl2, NaF solutions provided 89 percent, 67 percent, and 42 percent SL reduction respectively compared with the control, while in dentin they provided 60 percent, 23 percent, and 36 percent, respectively, all significant at p < 0.05. Phase II: Seventy-two (72) common proteins were identified in all groups, 30 exclusive to DIW, 20 to SnCl2/NaF, 19 to NaF, and 13 to SnCl2. SnCl2/NaF increased the abundance of pellicle proteins than each one alone. CONCLUSION: SnCl2/NaF showed the best anti-erosive effect on both enamel and dentin. The findings suggest that the composition of acquired pellicle changes with different solutions, which may be related to their anti-erosive effect.