Academic literature on the topic 'Dental repair/regeneration'
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Journal articles on the topic "Dental repair/regeneration"
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Jin, Yiyao, and Ruijie Zeng. "Research on the current situation of regenerative pulp surgery." Highlights in Science, Engineering and Technology 8 (August 17, 2022): 50–53. http://dx.doi.org/10.54097/hset.v8i.1109.
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Regenerative dental pulp therapy uses the principle of biological tissue engineering to replace the damaged dental pulp tissue with living tissue and repair the complex of dental pulp and dentin, so as to restore the normal function of dental pulp dentin structure. For root canal therapy, it is a new type of alternative therapy. In front of it, the treatment is divided into two types: cellular pulp regeneration therapy and acellular pulp regeneration therapy. Cellular regeneration is based on exogenous stem cell transplantation and acellular regeneration is based on endogenous stem cell homing. This paper reviews the latest progress in the treatment of regenerative dental pulp at home and abroad.
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Acurio- Cevallos, Sophia Isabella, Emily Estefanía López- Llerena, Rolando Manuel Benites, and Carla Pamela Rodríguez Fiallos. ""Dental regeneration therapy using dental stem cells”." Interamerican Journal of Health Sciences 4 (July 22, 2024): 86. http://dx.doi.org/10.59471/ijhsc202486.
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INTRODUCTION: Regenerative dentistry has undergone significant advances in recent years, and stem cells of dental origin have emerged as a promising therapeutic tool in this field. AIM: To investigate the different types of stem cells of dental origin and to examine their potential application in regenerative therapy in dentistry. METHODOLOGY: A selection of articles published between 2018 and 2023 was performed using the recognized databases Scopus, PubMed, ProQuest, Redalyc, Ovid and Medline. RESULTS: Five main sources of stem cells of dental origin were identified, which have demonstrated their ability to differentiate into specialized cells of dental tissue, such as odontoblasts, osteoblasts and myocytes, which have diverse applications such as in the treatment of periodontitis, bone repair, regeneration of dental pulp after necrosis and the development of new teeth. CONCLUSION: This study contributes to broaden our knowledge of this evolving field and highlights the importance of continuing to investigate and explore the therapeutic applications of dental stem cells.
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Ghosh, Sumanta, Wei Qiao, Zhengbao Yang, Santiago Orrego, and Prasanna Neelakantan. "Engineering Dental Tissues Using Biomaterials with Piezoelectric Effect: Current Progress and Future Perspectives." Journal of Functional Biomaterials 14, no. 1 (December 22, 2022): 8. http://dx.doi.org/10.3390/jfb14010008.
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Dental caries and traumatic injuries to teeth may cause irreversible inflammation and eventual death of the dental pulp. Nevertheless, predictably, repair and regeneration of the dentin-pulp complex remain a formidable challenge. In recent years, smart multifunctional materials with antimicrobial, anti-inflammatory, and pro-regenerative properties have emerged as promising approaches to meet this critical clinical need. As a unique class of smart materials, piezoelectric materials have an unprecedented advantage over other stimuli-responsive materials due to their inherent capability to generate electric charges, which have been shown to facilitate both antimicrobial action and tissue regeneration. Nonetheless, studies on piezoelectric biomaterials in the repair and regeneration of the dentin-pulp complex remain limited. In this review, we summarize the biomedical applications of piezoelectric biomaterials in dental applications and elucidate the underlying molecular mechanisms contributing to the biological effect of piezoelectricity. Moreover, we highlight how this state-of-the-art can be further exploited in the future for dental tissue engineering.
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Ghafoor, Robia. "Stem Cell Role in Regenerative Dental Medicine." Annals of Jinnah Sindh Medical University 8, no. 2 (December 30, 2022): 45–46. http://dx.doi.org/10.46663/ajsmu.v8i2.45-46.
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Regeneration therapies have widely permeated advanced research that aims to reproduce and repair a lost or damaged organ or tissue in order to restore the function and architecture as close to its original state as possible. Tissue engineering refers to the process of regeneration using techniques such as scaffold based cell cultures, stem cell therapy, and biomolecular signaling.
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Mitsiadis, T. A., A. Feki, G. Papaccio, and J. Catón. "Dental Pulp Stem Cells, Niches, and Notch Signaling in Tooth Injury." Advances in Dental Research 23, no. 3 (June 15, 2011): 275–79. http://dx.doi.org/10.1177/0022034511405386.
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Stem cells guarantee tissue repair and regeneration throughout life. The decision between cell self-renewal and differentiation is influenced by a specialized microenvironment called the ‘stem cell niche’. In the tooth, stem cell niches are formed at specific anatomic locations of the dental pulp. The microenvironment of these niches regulates how dental pulp stem cell populations participate in tissue maintenance, repair, and regeneration. Signaling molecules such as Notch proteins are important regulators of stem cell function, with various capacities to induce proliferation or differentiation. Dental injuries often lead to odontoblast apoptosis, which triggers activation of dental pulp stem cells followed by their proliferation, migration, and differentiation into odontoblast-like cells, which elaborate a reparative dentin. Better knowledge of the regulation of dental pulp stem cells within their niches in pathological conditions will aid in the development of novel treatments for dental tissue repair and regeneration.
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Ivanov, Alexey A., Alla V. Kuznetsova, Olga P. Popova, Tamara I. Danilova, and Oleg O. Yanushevich. "Modern Approaches to Acellular Therapy in Bone and Dental Regeneration." International Journal of Molecular Sciences 22, no. 24 (December 15, 2021): 13454. http://dx.doi.org/10.3390/ijms222413454.
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An approach called cell-free therapy has rapidly developed in regenerative medicine over the past decade. Understanding the molecular mechanisms and signaling pathways involved in the internal potential of tissue repair inspires the development of new strategies aimed at controlling and enhancing these processes during regeneration. The use of stem cell mobilization, or homing for regeneration based on endogenous healing mechanisms, prompted a new concept in regenerative medicine: endogenous regenerative medicine. The application of cell-free therapeutic agents leading to the recruitment/homing of endogenous stem cells has advantages in overcoming the limitations and risks associated with cell therapy. In this review, we discuss the potential of cell-free products such as the decellularized extracellular matrix, growth factors, extracellular vesicles and miRNAs in endogenous bone and dental regeneration.
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Alnasser, Muhsen, Abdullah Hammad Alshammari, Amna Yusuf Siddiqui, Osama Shujaa Alothmani, Rakhi Issrani, Azhar Iqbal, Osama Khattak, and Namdeo Prabhu. "Tissue Regeneration on Rise: Dental Hard Tissue Regeneration and Challenges—A Narrative Review." Scientifica 2024 (April 22, 2024): 1–13. http://dx.doi.org/10.1155/2024/9990562.
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Background. As people live longer, there is an increasing need for hard tissue regeneration and whole-tooth regeneration. Despite the advancements in the field of medicine, the field of regenerative dentistry is still challenging due to the complexity of dental hard tissues. Cross-disciplinary collaboration among material scientists, cellular biologists, and odontologists aimed at developing strategies and uncovering solutions related to dental tissue regeneration. Methodology. A search of the literature was done for pertinent research. Consistent with the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020 Statement, the electronic databases looked at were PubMed, Science Direct, Scopus, and Google Scholar, with the keyword search “hard dental tissue regeneration.” Results. Database analysis yielded a total of 476 articles. 222 duplicate articles have been removed in total. Articles that have no connection to the directed regeneration of hard dental tissue were disregarded. The review concluded with the inclusion of four studies that were relevant to our research objective. Conclusion. Current molecular signaling network investigations and novel viewpoints on cellular heterogeneity have made advancements in understanding of the kinetics of dental hard tissue regeneration possible. Here, we outline the fundamentals of stem hard dental tissue maintenance, regeneration, and repair, as well as recent advancements in the field of hard tissue regeneration. These intriguing findings help establish a framework that will eventually enable basic research findings to be utilized towards oral health-improving medicines.
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Miran, Shayee, Thimios A. Mitsiadis, and Pierfrancesco Pagella. "Innovative Dental Stem Cell-Based Research Approaches: The Future of Dentistry." Stem Cells International 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/7231038.
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Over the past decade, the dental field has benefited from recent findings in stem cell biology and tissue engineering that led to the elaboration of novel ideas and concepts for the regeneration of dental tissues or entire new teeth. In particular, stem cell-based regenerative approaches are extremely promising since they aim at the full restoration of lost or damaged tissues, ensuring thus their functionality. These therapeutic approaches are already applied with success in clinics for the regeneration of other organs and consist of manipulation of stem cells and their administration to patients. Stem cells have the potential to self-renew and to give rise to a variety of cell types that ensure tissue repair and regeneration throughout life. During the last decades, several adult stem cell populations have been isolated from dental and periodontal tissues, characterized, and tested for their potential applications in regenerative dentistry. Here we briefly present the various stem cell-based treatment approaches and strategies that could be translated in dental practice and revolutionize dentistry.
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Wu, David T., Jose G. Munguia-Lopez, Ye Won Cho, Xiaolu Ma, Vivian Song, Zhiyue Zhu, and Simon D. Tran. "Polymeric Scaffolds for Dental, Oral, and Craniofacial Regenerative Medicine." Molecules 26, no. 22 (November 22, 2021): 7043. http://dx.doi.org/10.3390/molecules26227043.
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Dental, oral, and craniofacial (DOC) regenerative medicine aims to repair or regenerate DOC tissues including teeth, dental pulp, periodontal tissues, salivary gland, temporomandibular joint (TMJ), hard (bone, cartilage), and soft (muscle, nerve, skin) tissues of the craniofacial complex. Polymeric materials have a broad range of applications in biomedical engineering and regenerative medicine functioning as tissue engineering scaffolds, carriers for cell-based therapies, and biomedical devices for delivery of drugs and biologics. The focus of this review is to discuss the properties and clinical indications of polymeric scaffold materials and extracellular matrix technologies for DOC regenerative medicine. More specifically, this review outlines the key properties, advantages and drawbacks of natural polymers including alginate, cellulose, chitosan, silk, collagen, gelatin, fibrin, laminin, decellularized extracellular matrix, and hyaluronic acid, as well as synthetic polymers including polylactic acid (PLA), polyglycolic acid (PGA), polycaprolactone (PCL), poly (ethylene glycol) (PEG), and Zwitterionic polymers. This review highlights key clinical applications of polymeric scaffolding materials to repair and/or regenerate various DOC tissues. Particularly, polymeric materials used in clinical procedures are discussed including alveolar ridge preservation, vertical and horizontal ridge augmentation, maxillary sinus augmentation, TMJ reconstruction, periodontal regeneration, periodontal/peri-implant plastic surgery, regenerative endodontics. In addition, polymeric scaffolds application in whole tooth and salivary gland regeneration are discussed.
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Luo, Lihua, Yan He, Xiaoyan Wang, Brian Key, Bae Hoon Lee, Huaqiong Li, and Qingsong Ye. "Potential Roles of Dental Pulp Stem Cells in Neural Regeneration and Repair." Stem Cells International 2018 (2018): 1–15. http://dx.doi.org/10.1155/2018/1731289.
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This review summarizes current advances in dental pulp stem cells (DPSCs) and their potential applications in the nervous diseases. Injured adult mammalian nervous system has a limited regenerative capacity due to an insufficient pool of precursor cells in both central and peripheral nervous systems. Nerve growth is also constrained by inhibitory factors (associated with central myelin) and barrier tissues (glial scarring). Stem cells, possessing the capacity of self-renewal and multicellular differentiation, promise new therapeutic strategies for overcoming these impediments to neural regeneration. Dental pulp stem cells (DPSCs) derive from a cranial neural crest lineage, retain a remarkable potential for neuronal differentiation, and additionally express multiple factors that are suitable for neuronal and axonal regeneration. DPSCs can also express immunomodulatory factors that stimulate formation of blood vessels and enhance regeneration and repair of injured nerve. These unique properties together with their ready accessibility make DPSCs an attractive cell source for tissue engineering in injured and diseased nervous systems. In this review, we interrogate the neuronal differentiation potential as well as the neuroprotective, neurotrophic, angiogenic, and immunomodulatory properties of DPSCs and its application in the injured nervous system. Taken together, DPSCs are an ideal stem cell resource for therapeutic approaches to neural repair and regeneration in nerve diseases.
Dissertations / Theses on the topic "Dental repair/regeneration"
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Patterson, Jennifer. "Regenerative matrices for oriented bone growth in craniofacial and dental repair /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/8018.
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Mbitta, Akoa Daline. "Silicon-delivering cellularized biomaterials for dental repair." Electronic Thesis or Diss., Sorbonne université, 2024. http://www.theses.fr/2024SORUS133.
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Le silicium est présent en quantités faibles mais non négligeables dans les fluides biologiques et il a été démontré qu'il était bénéfique pour la formation des os. Parallèlement, de nombreux matériaux à base de silice sont utilisés dans la réparation osseuse. En revanche, bien que les matériaux à base de silice soient utilisés en dentisterie comme matériaux de coiffage pulpaire pour la réparation de la dentine, très peu d'études ont démontré jusqu'à présent que le silicium peut avoir un impact sur la formation de la dentine. Dans ce contexte, le présent projet vise à préparer des matériaux qui permettent d'étudier le rôle du silicium sur la formation de la dentine. Ces matériaux combinent le collagène, la principale protéine de la dentine, et les cellules souches de la pulpe dentaire humaine. Dans un premier temps, des hydrogels de collagène denses ont été préparés par compression plastique et entièrement caractérisés en termes de structure et de propriétés mécaniques. Ils ont ensuite été utilisés comme hôtes pour les cellules souches de la pulpe dentaire afin d'étudier le comportement des cellules dans la matrice. Les résultats ont montré que cette méthode était sensible à de petites variations du protocole de préparation et des conditions de culture cellulaire. Une minéralisation effective a été obtenue avec une densité cellulaire de 2 M.mL-1 dans les gels. Dans un deuxième temps, nous avons analysé les effets du silicium soluble (acide silicique) sur les cellules souches de la pulpe dentaire dans la matrice collagénique. Nos résultats ont révélé que l'acide silicique à des doses supraphysiologiques (100 µM), bien que subtoxiques (< 1mM), réduit la formation minérale. Enfin, des hydrogels nanocomposites associant collagène et nanoparticules (silice et bioverres) relarguant du silicium ont été préparés. Comme dans l'étape 2, l'impact de ces nanoparticules sur les cellules souches de la pulpe dentaire a été évalué. Nos résultats ont montré un dépôt minéral comparable dans tous les gels. Alors que la distribution des cellules et le dépôt minéral dans la matrice contenant des nanoparticules de silice n'étaient pas uniformes, les gels contenant des bioverres présentaient une distribution cellulaire et une minéralisation homogènes. L'un des mécanismes proposés est que le silicium interagit avec la matrice de collagène, plutôt qu'avec les cellules, ce qui peut entraver la fonction minéralisatrice des cellules. Ces résultats offrent un aperçu précieux de la place biologique du silicium dans les applications dentaires et peuvent contribuer à l'amélioration de ces matériaux dans le cadre de l'ingénierie des tissus minéralisésSilicon is present in low but non-negligible amounts in biological fluids and has been shown to be beneficial for bone formation. In parallel, many silica-based materials are used in bone repair. In sharp contrast, although silica-based materials are used in dentistry as pulp capping materials for dentin repair, very few studies to date have demonstrated that silicon can have an impact on dentin formation. In this context, the present project aims at preparing materials that allow for studying the role of silicon on dentin tissue formation. These materials combined collagen, the main protein in dentin, and human dental pulp stem cells.In a first step, dense collagen hydrogels were prepared using plastic compression method, and fully characterized in terms of structure and mechanical properties. Then they were used as hosts for dental pulp stem cells to study the behaviour of the cells within the matrix. Results showed that this method was sensitive to small differences in protocol preparation and cell culture conditions. Successful mineralization was achieved with a cell density of 2 M.mL-1 within the gels.In a second step, we analyzed the effects of soluble silicon (silicic acid) on dental pulp stem cells in the collagenous matrix. Our results revealed that silicic acid at supraphysiological doses (100 µM), although subtoxic (< 1mM), reduce mineral formation.Finally, nanocomposites hydrogels combining collagen and silicon-releasing nanoparticles (silica and bioglasses) were prepared. As in the 2nd step, the impact these silica-based nanoparticles on the dental pulp stem cells was assessed. Our findings showed that the extent of mineral deposition was comparable in all gels. While cell distribution and mineral deposition in the matrix with silica nanoparticles were not uniform, gels containing bioglasses showed homogeneous cell distribution and mineralization. A proposed mechanism is that silicon interacts with collagenous matrix, rather than cells themselves, and this may be detrimental to the cell mineralization function. These results offer valuable insight into the biological importance of silicon in dental applications and may contribute to the improvement of these materials as part of mineralized tissue engineering strategies
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Kushnerev, Evgeny. "Dental pulp stem cells : investigations into methods of enhancing regeneration and repair of the cornea." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/dental-pulp-stem-cells--investigations-into-methods-of-enhancing-regeneration-and-repair-of-the-cornea(d2b05828-99df-4913-a1cf-1b080d2ec3bf).html.
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The cornea is the transparent, avascular and highly innervated outer anterior layer of the eye. The cornea is a very delicate structure and any traumatic insult may lead to damage and limbal stem cell deficiency (LSCD), leading to chronic discomfort, visual impairment and ultimately blindness. The resultant issues can have a significant effect on patients and reduce their quality of life. Whilst conservative and therapeutic management of these problems play a part in the treatment of corneal injuries often surgery is indicated. However, surgical repair of damaged corneas may be limited by the availability of suitable donor tissue and donor site morbidity. Corneal grafts or penetrating keratoplasty (PK) or donor limbal grafts may lead to surgical complications such as corneal scarring, infection and graft rejection. First described in 1908 by A. Maximow, stem cells offer the opportunity to produce functional cell specific tissues from undifferentiated “primordial” cells. By using stem cells from human adult or deciduous tooth pulp, repair and regeneration of the cornea may be possible. Furthermore, it may lead to development of new and innovative treatments of other corneal disorders and injuries. The aim of the investigations detailed in this thesis was to characterize dental pulp stem cells (DPSC), help establish their use in regenerative medicine and help enhance the repair and regeneration of damaged corneal epithelium. Using various laboratory techniques including PCR, western blot and immunostaining it was determined that DPSC possess adequate potency and plasticity to be differentiated into a number of cell-lines. Co-culture of DPSC with human cornea demonstrated that stem cells were attracted to the tissue and migrate towards it and attach to the surface of the limbal explant. Additionally, using soft contact lenses it has been shown that DPSC can be successfully transferred from culture to human cornea in vitro. Expression of terminally differentiated corneal epithelium markers such as cytokeratin 3 & 12 further supports the concept that DPSC were transdifferentiated into epithelial progenitor cells. Once transferred onto the corneal surface, DPSC supported corneal epithelium regeneration, allowed corneal epithelial like cells to grow and avert conjunctivalisation and thus maintained cornea transparency. Further studies are needed to provide a better understanding of the DPSC’s role in corneal regeneration, but it is clear that DPSC are promising candidates for this novel and non-invasive method of corneal epithelium regeneration.
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Melo, Alexandre de. "Estudo da reparação do alvéolo dental de ratos wistar preenchido com osso autógeno particulado após exodontia." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/42/42131/tde-03012008-151813/.
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O objetivo deste trabalho foi investigar a influência do enxerto ósseo autógeno particulado no processo de reparo do alvéolo dental de ratos Wistar após exodontia. Os animais foram divididos em grupos controle e experimental. Os ratos controles foram submetidos à intervenção cirúrgica para exodontia do incisivo superior direito apenas, enquanto nos ratos experimentais foram realizadas a exodontia e enxertia óssea no alvéolo dental. A eutanásia dos ratos foi realizada no 5o, 15o, 21o e 28o dias de pós-operatório. As amostras obtidas foram processadas para análise histológica. A densidade de área ocupada por osso foi quantificada por um método de contagem diferencial de pontos e com auxílio de um programa de imagens. Os resultados mostraram que a densidade de área preenchida por tecido ósseo não apresentou diferenças estatísticas em nenhum dos tempos pós-operatórios nos grupos analisados. Concluiu-se que o enxerto ósseo autógeno não promoveu um aumento significativo da neoformação óssea no alvéolo dental após exodontia.After tooth extraction a continuous bone resorption of the alveolar process is observed in the maxilla and in the mandible. The unfavorable anatomy of the reabsorbed bone ridge limits the rehabilitation of the edentulous area with prostheses over dental implants. Filling the dental alveolus after the exodontia with bone grafts and/or biomaterials is a procedure that tries to delay the physiologic resorption of the alveolar process and stimulates bone formation. The aim of this study is to investigate the influence of the particulated autogenous bone graft in the alveolar socket healing following tooth extraction in Rattus Norvegicus Albinus lineage Wistar. Sixty-seven male rats were used, each weighing 190 to 250 g. The animals were divided in a control and an experimental group. The upper right incisor was extracted in the rats of both groups. Following the tooth extraction, in the animals of the experimental group, the socket was grafted with particulated autogenous bone. The bone graft was obtained from the iliac bone of the same grafted animal. At 7, 14 and 21 days of postoperative, some rats received subcutaneous applications of the ossification marker calcein dissolved in a sodium bicarbonate 2% solution. The euthanasia of the animals was accomplished in the 5th, 15th, 21st and 28th days of postoperative. After the euthanasia the bone parts that contain the dental socket of each right maxilla were removed and reduced to small samples. All the samples were then fixed and processed for histological analysis. The total area of bone was quantified in the socket by a differential point-counting method and by use of an image analyzing program. The data were analyzed statistically and showed that there was a progressive increase of the bone total area during the postoperative periods. However, the morphometric analysis of the total area of bone in the control and experimental groups, did not show a significant statistical difference in none of the postoperative periods. The results reveal that the autogenous bone graft did not promote a significant increase of the bone new formation in the dental socket following tooth extraction.
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Collignon, Anne-Margaux. "Utilisation de cellules souches pulpaires combinées à une matrice de collagène pour la réparation osseuse cranio-faciale Strategies developed to induce, direct, and potentiate bone healing Accelerated craniofacial bone regeneration through dense collagen gel scaffolds seeded with dental pulp stem cells Mouse Wnt1-CRE-RosaTomato dental pulp stem cells directly contribute to the calvarial bone regeneration process Early angiogenesis detected by PET imaging with 64Cu-NODAGA-RGD is predictive of bone critical defect repair." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB113.
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La région cranio-faciale est particulièrement vulnérable aux pertes de structures. Sa localisation et sa visibilité font qu'une atteinte entraîne des troubles, aussi bien physiques (alimentation, phonation...) que psychologiques (intégrité de la personne...). Les traitements actuels (régénération osseuse guidée, autogreffe osseuse ou allogreffe) sont particulièrement invasifs et présentent un taux d'échec élevé. Tout cela affecte fortement la qualité de vie du patient. De plus, le coût direct de ces traitements est important pour les systèmes de santé et le patient. Il existe donc un réel besoin de développer des traitements innovants basés sur des approches biomimétiques d'ingénierie tissulaire pour la régénération/réparation osseuse. L'objectif de ce travail est de développer une approche d'ingénierie tissulaire pour la réparation/régénération de tissus osseux cranio-faciaux lésés. Il est basé sur l'utilisation de matrices cellularisées avec des cellules souches mésenchymateuses issues de la pulpe dentaire : les Dental Pulp Stem Cells (DPSCs). De nombreux travaux ont démontré la grande plasticité de ces cellules, qui dérivent initialement de la crête neurale, mais aussi leur rôle trophique dans la réparation de tissus lésés par leur capacité de différenciation ostéogénique et chondrocytaire. Par ailleurs, ces cellules présentent des propriétés pro-angiogéniques supérieures aux cellules mésenchymateuses de la moelle osseuse (MSCs) et l'accès à cette réserve est aisé puisqu'elles peuvent être obtenues à partir de dents extraites. Dans ce contexte, nous avons à ce jour utilisé des matrices denses de collagène contenant des cellules souches pulpaires pour régénérer un tissu osseux crânien après réalisation de défauts critiques. L'objectif est d'induire très précocement une néo-angiogenèse favorisant à court terme la survie des cellules implantées, puis de stimuler leur maintien à long terme au sein du néo-tissu implanté, pour enfin provoquer une ostéoformation. Nous avons, ainsi, pu étudier et valider différents aspects de cette thématique : .1 L'impact positif de l'utilisation de matrices denses de collagène comme support ostéoconducteur, .2 Le suivi à long terme des cellules après implantation in vivo .3 L'impact positif d'un pré-traitement à l'hypoxie sur i/ la survie des cellules après implantation in vivo ii/ la potentialisation de leur apport pour la régénération/réparation osseuse en orientant leur différenciation vers une voie ostéoblastique, .4 L'apport significatif des techniques d'imageries pour le suivi des animaux grâce à la tomographie par émission de positons (utilisation de traceurs spécifiques de la minéralisation au sein des matrices et de la néo-angiogenèse) et au microscanner à rayons X (suivi cinétique de la qualité et de la quantité de matrice osseuse régénérée), .5 La validation et la confirmation de l'ensemble de ces résultats par l'histologie. Ainsi, ces résultats nous ont permis de répondre à l'objectif de travail et de perfectionner certains aspects de la composante cellulaire. Toutefois, il reste nécessaire d'optimiser le biomatériau lui-même. Il est en effet envisageable d'améliorer les matrices de collagène compressées que nous utilisons actuellement, en y intégrant par exemple des céramiques bioactives. En perspective, potentialiser les biomatériaux des matrices et combiner les DPSCs avec un support plus adapté à leur survie et à leur croissance permettrait d'améliorer considérablement la cicatrisation osseuse. Ces dernières années, l'étude des cellules souches a progressé d'approche in vitro vers l'in vivo. Les modèles in vivo établis pour étudier ces cellules dans le domaine cranio-facial ont déjà apporté des renseignements et ce travail s'inscrit dans leur continuité en cherchant à concevoir des stratégies adaptées pour l'utilisation future des DPSCs en ingénierie tissulaireThe craniofacial area is particularly vulnerable to structural loss. Its location and visibility make a loss causes disorders, both physical (food, phonation...) than psychological (integrity of the person...). Current treatments (autografts, allografts or synthetic bone grafts) are particularly invasive and have a high failure rate. All this strongly affects the quality of life of the patient. In addition, the cost of these treatments is significant for the health systems and the patient. Therefore, there is a real need to develop innovative treatments based on biomimetic tissue approaches for bone repair. The purpose of this thesis is to develop a tissue engineering approach for the repair/regeneration of injured cranial-facial bone tissue. It is based on the use of cellularized scaffolds with mesenchymal stem cells derived from the dental pulp: Dental Pulp Stem Cells (DPSCs). Many studies have demonstrated the high plasticity of these cells, which initially derive from the neural crest, but also their trophic ability in the repair of damaged tissues by their osteogenic and chondrocyte differentiation capacity. Moreover, these cells have better's pro-angiogenic properties than mesenchymal cells of the bone marrow (MSCs) and access to this reserve is easy since they can be obtained from extracted teeth. In this context, we have used dense collagen scaffolds seeded with DPSCs to regenerate cranial bone tissue on critical defects model. The objective is to induce a very early neo-angiogenesis for improved short-term survival of implanted cells, then stimulate the long-term maintenance of cells in the implanted neo-tissue, finally to cause osteoformation. We were able to study and validate various aspects of this theme: 1- The positive impact of the use of dense collagen scaffold as osteoconductive support, 2- Long-term follow-up of the cells after implantation in vivo (thanks to the use of a cell line constitutively expressing an intracellular fluorescence protein), 3- The positive impact of a pre-treatment with hypoxia on i/ the survival of the cells after implantation in vivo ii/ their contribution to bone regeneration / repair by orienting their differentiation towards an osteoblastic pathway, 4- The significant contribution of imaging techniques for the monitoring of animals (less sacrifice and longitudinal follow-up...) thanks to positron emission tomography (use of specific tracers of the mineralization within the scaffolds and neo-angiogenesis) and X-ray microscanner (kinetic monitoring of the quality and quantity of regenerated bone matrix) 5- Validation and confirmation of all these results by histology. Thus, these different results allowed us to respond to the working hypothesis and optimize some aspects of the cellular component. However, it remains necessary to optimize the biomaterial itself. It is indeed possible to improve the compressed collagen scaffolds that we currently use, for example by incorporating bioactive ceramics such as bioglasses or hydroxyapatite. In recent years, the study of stem cells has progressed from in vitro to in vivo. The in vivo models established to study these cells in the craniofacial area have already provided valuable information and this work is a continuation of these previous studies by seeking to build on better strategies (right characterization, environment oriented...) for the future use of DPSCs for tissue engineering purposes. In view of this work, potentiating the biomaterials of the scaffolds and combining the DPSCs with a support more adapted to their survival and their growth would considerably improve bone healing, as well as bone regeneration / repair
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Ribeiro, Fernanda Vieira. "Efeito do meloxicam sobre o reparo osseo ao redor de implantes de titanio." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/287909.
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Orientadores: Marcio Zaffalon Casati, Francisco Humberto Nociti JuniorDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba
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Resumo: O objetivo deste estudo foi avaliar a influência de um antiinflamatório não esteroidal inibidor seletivo de COX-2, meloxicam, sobre o reparo ósseo ao redor de implantes de titânio colocados em tÃbias de ratos. Foram utilizados 31 ratos Wistar, machos, adultos, os quais receberam um implante dental de titânio em uma das tÃbias. Após a colocação dos implantes, os animais foram aleatoriamente incluÃdos nos seguintes grupos: Controle (n=14): 1 ml/kg de solução fisiológica de cloreto de sódio a 0,9% esterilizada e Teste (n=17): 3 mg/kg de meloxicam, ambos administrados via subcutânea, diariamente, durante 60 dias. Os animais foram mortos após 60 dias da cirurgia de colocação dos implantes. Secções não descalcificadas foram obtidas e avaliadas histometricamente. Foram avaliados os seguintes parâmetros: porcentagem de tecido ósseo em contato direto com a superfÃcie do implante (CD), porcentagem de preenchimento ósseo dentro das roscas do implante (PR) e porcentagem de osso numa região 500 µm adjacente à superfÃcie do implante (OA). Os dados foram obtidos separadamente para região cortical (A) e região medular (B). O teste não paramétrico de Mann-Whitney (a= 5%) foi utilizado para a análise estatÃstica. Os resultados demonstraram que o meloxicam reduziu significativamente o reparo ósseo ao redor dos implantes. Para a região A, diferenças significantes foram observadas com relação ao CD (47,01 ± 10,48 A; 35,93 ± 12,25 B), PR (86,42 ± 3,66 A; 61,58 ± 12,09 B) e OA (96,86 ± 0,96 A; 91,06 ± 3,05 B), entre os grupos controle e teste, respectivamente (p<0,05). Para a região B, a análise dos dados também mostrou diferenças significantes entre os grupos controle e teste, respectivamente (p<0,05), para CD (30,76 ± 13,80 A; 16,86 ± 11,48 B), PR (34,83 ± 8,18 A; 25,66 ± 9,16 B) e AO (15,76 ± 7,05 A; 7,73 ± 4,61 B). Dentro dos limites do presente estudo, concluiu-se que a administração de 3 mg/kg/dia de meloxicam influenciou negativamente o reparo ósseo, tanto no osso cortical quanto medular, ao redor de implantes de titânio inseridos em tÃbias de ratos
Abstract: The aim of this study was to investigate the effect of a selective cyclooxygenase-2 inhibitor, meloxicam, on bone healing around titanium implants in rats. Thirty-one adult male Wistar rats were included in this study and one screw-shaped titanium implant was inserted in the tibiae. The animals were randomly assigned to one of the following groups, for daily subcutaneous injections: Control (n=14): 1 ml/kg of saline solution and Test (n=17): 3 mg/kg of meloxicam, each administered daily for 60 days. After the treatment, the animals were sacrificed and undecalcified sections obtained. Bone-to-implant contact (BIC) and bone filling within the limits of of implant threads (BF) and percentage of bone in a 500µm-wide zone lateral to the implant (BL) were obtained and arranged for cortical (zone A) and cancellous (zone B) bone regions. The data were tested by the Mann-Whitney test (a= 5%). Intergroup comparisons demonstrated that meloxicam significantly reduced bone healing around implants. For zone A, significant differences were observed regarding BIC (47.01 ± 10.48 A; 35.93 ± 12.25 B), BF (86.42 ± 3.66 A; 61.58 ± 12.09 B) and BL (96.86 ± 0.96 A; 91.06 ± 3.05 B) for control and test groups, respectively (p<0.05). For zone B, data analysis also showed significant differences among the groups for BIC (30.76 ± 13.80 A; 16.86 ± 11.48 B), BF (34.83 ± 8.18 A; 25.66 ± 9.16 B) and BL (15.76 ± 7.05 A; 7.73 ± 4.61 B) for control and test groups, respectively (p<0.05). In conclusion, within the limits of the present study, 3 mg/kg/day of meloxicam may negatively influence bone healing in the cortical and cancellous bone around titanium implants inserted in rats after continuous administration
Mestrado
Periodontia
Mestre em Clínica Odontológica
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Pacheco, Cindy Grace Pérez. "AVALIAÇÃO DO EFEITO DO LASER DE BAIXA INTENSIDADE NO PROCESSO DE REPARO DE ALVÉOLOS PÓS-EXODONTIA TRATADOS COM HIDROXIAPATITA E OSSO BOVINO INORGÂNICO EM RATOS." Universidade Estadual de Ponta Grossa, 2016. http://tede2.uepg.br/jspui/handle/prefix/2488.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Os biomateriais e a fotobioengenharia são técnicas usadas com o intuito de melhorar o reparo ósseo e prevenir a reabsorção dos alvéolos após exodontia. O objetivo deste estudo foi avaliar o efeito da Terapia de Laser de Baixa Intensidade (TLBI) comparativamente ao processo de reparo ósseo pós-exodontia em alvéolos de ratos tratados com hidroxiapatita +β -fosfato tricálcico (HA) e osso bovino inorgânico (OB). Foram utilizados 48 ratos machos divididos em seis grupos e subdivididos de acordo com o tempo de sacrificio (7 e 14 dias). C: coágulo, CL: Coágulo + TLBI, OB: osso bovino inorgânico, OBL: osso bovino inorgânico + TLBI, HA: hidroxiapatita +β -fosfato tricálcico e HAL: hidroxiapatita +β -fosfato tricálcico + TLBI. A TLBI (GaAlAs, λ780nm, 10mW, Ø0,4cm, 75J/cm2, 300s) foi aplicada no alvéolo imediatamente após exodontia, no dia seguinte, no terceiro e quinto dia após exodontia. Após 7 e 14 dias, 4 animais por grupos foram sacrificados. As amostras foram processadas e coradas com H-E para análise histológica e histomorfométrica. Aos 7 dias, encontrou-se uma maior quantidade de vasos sanguíneos em todos os grupos irradiados; e um maior número de osteoblastos mas somente houve diferença significante entre os grupos CL7 (coágulo + TLBI) e OB7 (osso bovino inorgânico). Aos 14 dias, observou-se novamente mais vasos sanguíneos nos grupos irradiados; como também, maior presença de matriz óssea; porém, não estatisticamente significantes. Com o protocolo usado no presente estudo concluímos que a TLBI mostrou uma tendência na estimulação na fase inicial do reparo ósseo, sugerida pela maior proliferação celular osteoblástica e endotelial.
Biomaterials and the photobioengineering are techniques that emerged in order to enhance bone healing and prevent the reabsorption of sockets after the tooth extraction. The aim of this study was to evaluate the effect of low level laser therapy (LLLT) comparatively to the process of bone healing in post extraction sockets of rats treated with hydroxyapatite + β-tricalcium phosphate (HA) and inorganic bovine bone (IBB). Forty-eight male rats were divided into 6 groups and subdivided according to sacrifice time (7 and 14 days): C: clot, CL: Clot + LLLT, IBB: inorganic bovine bone, IBBL: inorganic bovine bone + LLLT, HA: hydroxyapatite + β-tricalcium phosphate and HAL: hydroxyapatite + β-tricalcium phosphate + LLLT. The LLLT (GaAlAs, λ780nm, 10mW, Ø0,4cm, 75J/cm2, 300s) was applied to the socket immediately after the extraction, the next day, in the third and fifth day. At 7 and 14 day, 4 animals per group were sacrificed. Samples were processed and stained with H-E for histological and histomorphometric analysis. At 7 day, greater presence of blood vessels was observed in all irradiated groups; as well as more quantity of osteoblasts but there was only statistically different between CL7 (clot + LLLT) and OB7 (inorganic bovine bone) groups. At 14 day, more blood vessels were counted in the irradiated groups; a greater presence of matrix bone was observed suggesting bone formation; however, without statistical difference. In the protocol used in this work, we conclude that LLLT had a tendency in the bioestimulation of the bone healing in its early phase based in the better proliferation of endothelial and osteoblastic cells.
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Vallés, Lluch Ana. "P(EMA-co-HEA)/SiO2 hybrid nanocomposites for guided dentin tissue regeneration: structure, characterization and bioactivity." Doctoral thesis, Universitat Politècnica de València, 2008. http://hdl.handle.net/10251/3795.
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Se sintetizaron nanocompuestos híbridos en bloque de poli(etil metacrilato-co-hidroxietil acrilato) 70/30 wt%/sílice, P(EMA-co-HEA)/SiO2, con distintas proporciones de sílice hasta el 30 wt%. El procedimiento de síntesis consistió en la copolimerización de los monómeros orgánicos durante la polimerización sol-gel simultánea de tetraetoxisilano, TEOS como precursor de sílice.
El TEOS se hidroliza eficientemente y condensa dando lugar a sílice, y presenta una distribución homogénea en forma de agregados inconexos de nanopartículas de sílice elementales en los híbridos con bajos contenidos de sílice (<10 wt%) o redes continuas interpenetradas con la red orgánica tras la coalescencia de los agregados de sílice (>10 wt%). La red polimérica orgánica se forma en los poros producidos en el interior de las nanopartículas elementales de sílice, y también en los poros formados entre los agregados de nanopartículas.
Los nanohíbridos con contenidos de sílice intermedios (10-20 wt%) exhibieron las propiedades más equilibradas e interesantes: i) refuerzo mecánico de la matriz orgánica conseguida gracias a redes de sílice continuas e interpenetradas, ii) buena capacidad de hinchado debida a la expansión de la red orgánica no impedida todavía por un esqueleto de sílice rígido, y a un número alto de grupos silanol terminales hidrófilos (concentraciones inorgánicas en los alrededores de la coalescencia), y iii) mayor reactividad superficial debido a un contenido relativo bastante elevado de grupos polares silanol terminales disponibles en las superficies.
La 'bioactividad' o capacidad de los materiales en bloque de formar hidroxiapatita (HAp) sobre sus superficies fue estudiada in vitro sumergiéndolos en fluido biológico simulado (simulated body fluid, SBF). La formación de la capa de HAp viene controlada por el mecanismo y el tiempo de inducción a la nucleación de la misma, que dependen a su vez de la estructura de la sílice.Vallés Lluch, A. (2008). P(EMA-co-HEA)/SiO2 hybrid nanocomposites for guided dentin tissue regeneration: structure, characterization and bioactivity [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/3795
Palancia
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SILVA, Janaína Benfica e. "Avaliação do processo de raparo de lesões periopicais pós-tratamento endodôntico por meio de subtração digital radiográfica." Universidade Federal de Goiás, 2006. http://repositorio.bc.ufg.br/tede/handle/tde/1383.
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Previous issue date: 2006-11-30Control of the process of repair or progression of periapical lesions after endodontic treatment is monitored by conventional or digital radiography. In this research digital subtraction radiography (DSR) was used that uses the subtraction of images longitudinally, in which the change in the alveolar bone is visualized against a uniform gray background. The objectives of this study were: (1) to evaluate the repair process of periapical lesions after endodontic treatment by using DSR; (2) to quantify by means of point/pixel (picture element), area (histogram) and linear measures (profile line), the gain or loss of mineral density in the area of the lesion, using the average of the pixel values; (3) to compare the diagnostic information, suggestive of the repair process, obtained through a subjective evaluation of DSR with a conventional radiographic evaluation and digitalized image and (4) to evaluate the contribution of DSR to an early identification of the repair of periapical lesions after endodontic treatment. The sample consisted of twelve patients with a total of seventeen periapical lesions. The x-rays were digitalized and submitted to DSR using DSR software. The pixel values of the subtracted images were determined by using Image Tool software. Both the conventional x-rays as well as the digitalized and subtracted images were qualitatively evaluated. The results showed a gain in mineral density with a meandp of 133.495.17, 130.275.77 and 129.414.46 for the points/pixel, histogram and profile line tools, respectively. In the evaluation of numerical gain Pearson s Coefficient of Correlation (r) presented these values: mean of points/histogram = 0.746; mean of points/profile line = 0.724 and histogram/profile line = 0.860. When the numerical values were transformed into percentile gain meandp of 0.674.01, 1.214.33 and 1.163.36 were obtained for the points/pixels, histogram and profile line tools, respectively. In the evaluation of the percentile gain Spearman s Coefficient of Correlation (rs) showed the following values: mean of points/histogram = 0.697; mean of the points/profile line = 0.646 and histogram/profile line = 0.844. In the qualitative analysis, the frequency of success in the ordering of the correct sequence of the repair process using conventional radiography, digitalized image and DSR was 37.3%, 31.4% and 31.4%, respectively. One concluded, therefore, that: (1) the process of repair of periapical lesions after endodontic treatment can be evaluated quantitatively by means of longitudinal analysis using DSR; (2) any one of the three tools can be used to quantify the repair, considering that correlation exists between the time of repair and the increase of the value of pixel; (3) the comparative evaluation between the subjective methods using conventional radiography, digitalized image and SDR, it showed that all had been capable to evidence the process of repair of periapical lesions from the first radiography (15 days), not having difference between them and (4) the quantitative evaluation by SDR obtained to after evidence the beginning of the repair with 15 days the beginning of the endodontic treatment, even so this repair was really effective from 105 days after the beginning of the endodontic treatment.
O controle do processo de reparo ou progressão de lesões periapicais pós-tratamento endodôntico é monitorado pelo exame radiográfico convencional ou digital. Nesta pesquisa foi utilizada a subtração digital radiográfica (SDR), que utiliza a subtração de imagens longitudinalmente, na qual a mudança no osso alveolar é visualizada contra um plano de fundo (background) cinza homogêneo. Os objetivos desse estudo foram: (1) avaliar o processo de reparo de lesões periapicais pós-tratamento endodôntico por meio de SDR; (2) quantificar por meio de ponto/pixel (picture element), área (histograma) e medida linear (perfil linha) na área da lesão, o ganho ou perda de densidade mineral por meio da média dos valores dos pixels; (3) comparar as informações diagnósticas, sugestivas do processo de reparo, obtidas por meio da avaliação subjetiva da SDR com a avaliação radiográfica convencional e imagem digitalizada; e (4) avaliar a contribuição da SDR na identificação precoce do reparo de lesões periapicais pós-tratamento endodôntico. A amostra constituiu-se de doze indivíduos totalizando dezessete lesões periapicais. As radiografias foram digitalizadas e submetidas à SDR utilizando o programa DSR. As imagens subtraídas tiveram os valores de pixel determinados utilizando o programa Image Tool. Tanto as radiografias convencionais quanto as imagens digitalizadas e subtraídas foram avaliadas qualitativamente. Os resultados evidenciaram ganho de densidade mineral com médiadp de 133,495,17; 130,275,77; 129,414,46 para as ferramentas ponto/pixel; histograma e perfil linha respectivamente. Na avaliação do ganho numérico o Coeficiente de Correlação de Pearson (r) mostrou valores de: média dos pontos/ histograma = 0,746; média dos pontos/ perfil linha = 0,724 e histograma/ perfil linha = 0,860. Quando os valores numéricos foram transformados em ganho percentual foram obtidas médiadp de 0,674,01; 1,214,33; 1,163,36 para as ferramentas ponto/pixel; histograma e perfil linha respectivamente. Na avaliação do ganho percentual o Coeficiente de Correlação de Spearman (rs) mostrou valores de: média dos pontos/ histograma = 0,697; média dos pontos/ perfil linha = 0,646 e histograma/ perfil linha = 0,844. Na análise qualitativa, a freqüência de acertos na ordenação da seqüência correta do processo de reparo usando radiografia convencional, imagem digitalizada e SDR foi de 37,3%; 31,4% e 31,4% respectivamente. Concluiu-se, portanto, que: (1) o processo de reparo de lesões periapicais pós-tratamento endodôntico pode ser avaliado quantitativamente por meio de análise longitudinal com SDR (2) qualquer uma das três ferramentas pode ser utilizada para quantificar o reparo, considerando que existe correlação entre o tempo de reparo e o aumento do valor de pixel; (3) a avaliação comparativa entre os métodos subjetivos, usando radiografia convencional, imagem digitalizada e a SDR, mostrou que todos foram capazes de evidenciar o processo de reparo de lesões periapicais desde a primeira radiografia (15 dias), não havendo diferença entre eles e (4) a avaliação quantitativa por meio de SDR conseguiu evidenciar o início do reparo com 15 dias após o início do tratamento endodôntico, embora esse reparo fosse realmente efetivo a partir de 105 dias após o início do tratamento endodôntico.
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Milosta, Vladyslav. "Células estaminais dentárias e regeneração dentária: revisão narrativa." Master's thesis, 2021. http://hdl.handle.net/10284/10697.
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A regeneração dentária baseia-se no uso de materiais, que têm que permitir o funcionamento adequado da dentição. A eficácia e durabilidade das terapias usadas é questionável, sendo necessários métodos biológicos alternativos que possibilitem um equilíbrio entre a formação do novo tecido dentário e as funções fisiológicas do dente. Diferentes tipos de células estaminais e novos métodos biológicos, têm sido aplicados na pesquisa de regeneração dentária. As células estaminais dentárias são cada vez mais uma fonte dessas pesquisas. Face à complexidade e inovação do tema, o presente trabalho teve como objetivo realizar uma revisão narrativa sobre o estado de arte na utilização de células estaminais dentárias na reparação ou regeneração total dos dentes permanentes. Mantêm-se desafios significativos como a integração sinérgica de sinais estruturais e moléculas biológicas relevantes, tamanho e forma anatómica da coroa, formação de um periodonto adequado e complicações que podem ocorrer durante ou após o transplante.Dental regeneration is based on the use of materials, which have to allow proper functioning of the dentition. The effectiveness and durability of the therapies used are questionable, and alternative biological methods are needed, allowing a balance between the formation of new tooth tissue and the physiological functions of the tooth. Different types of stem cells and new biological methods have been applied in tooth regeneration research. Dental stem cells are increasingly becoming a source of such research. In view of the complexity and innovation of the topic, the present work aimed to conduct a narrative review on the state of the art in the use of dental stem cells in the repair or total regeneration of permanent teeth. Significant challenges remain such as the synergistic integration of relevant structural signals and biological molecules, size and anatomical shape of the crown, formation of an adequate periodontium, and complications that may occur during or after transplantation.
Book chapters on the topic "Dental repair/regeneration"
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Simon, Stephane, and Michel Goldberg. "Regenerative Endodontics: Regeneration or Repair?" In The Dental Pulp, 267–76. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-55160-4_19.
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Galler, Kerstin M. "Scaffolds for Pulp Repair and Regeneration." In The Dental Pulp, 251–65. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-55160-4_18.
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Prabhu, S. R. "Healing: Tissue Regeneration and Repair." In Textbook of General Pathology for Dental Students, 49–56. Cham: Springer Nature Switzerland, 2023. http://dx.doi.org/10.1007/978-3-031-31244-1_7.
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Tansık, Gulistan, Alper Devrim Ozkan, Mustafa O. Guler, and Ayse B. Tekinay. "Nanomaterials for the Repair and Regeneration of Dental Tissues." In Therapeutic Nanomaterials, 153–71. Hoboken, NJ: John Wiley & Sons, Inc, 2016. http://dx.doi.org/10.1002/9781118987483.ch7.
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Shulman, Leonard B. "The Current Status of Allogeneic Tooth Transplantation: Attachment Repair, Regeneration and Development in Dental Replants, Transplants and Implants." In Ciba Foundation Symposium 11 - Hard Tissue Growth, Repair and Remineralization, 91–119. Chichester, UK: John Wiley & Sons, Ltd., 2008. http://dx.doi.org/10.1002/9780470719947.ch5.
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Chandra, Satish, Shaleen Chandra, Girish Chandra, and Mithilesh Chandra. "Repair and Regeneration of Dental Tissues." In Textbook of Dental and Oral Histology with Embryology and Multiple Choice Questions, 331. Jaypee Brothers Medical Publishers (P) Ltd., 2010. http://dx.doi.org/10.5005/jp/books/10905_19.
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Jazayeri, Hossein E., Farahnaz Fahimipour, Mohammadreza Tahriri, Luis Almeida, and Lobat Tayebi. "Oral nerve tissue repair and regeneration." In Biomaterials for Oral and Dental Tissue Engineering, 319–36. Elsevier, 2017. http://dx.doi.org/10.1016/b978-0-08-100961-1.00019-0.
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Saberian, Elham, Andrej Jenča, Yaser Zafari, Andrej Jenča, Adriána Petrášová, and Janka Jenčová. "The Regeneration in Dentistry with Scaffolds Application." In The Regeneration in Dentistry with Scaffolds Application. IntechOpen, 2024. http://dx.doi.org/10.5772/intechopen.115062.
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“The Regeneration in Dentistry with Scaffolds Application” explores the dynamic interplay between scaffolds, stem cells, and growth factors in tissue engineering and regenerative dentistry. Scaffolds, resembling the extracellular matrix, serve as architectural frameworks, guiding stem cell behavior and tissue regeneration. Stem cells, with their remarkable plasticity, contribute to repair and restoration. Growth factors orchestrate cellular processes, promoting healing and tissue renewal. This comprehensive book delves into scaffold design, stem cell types, and growth factor applications, emphasizing their pivotal role in modern dental care.
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Smith, Anthony (Tony) J., and Paul R. Cooper. "Cellular Signaling in Dentin Repair and Regeneration." In Stem Cell Biology and Tissue Engineering in Dental Sciences, 405–17. Elsevier, 2015. http://dx.doi.org/10.1016/b978-0-12-397157-9.00036-9.
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S. Haidar, Ziyad. "Salivary Gland Radio-Protection, Regeneration and Repair: Innovative Strategies." In BioMechanics and Functional Tissue Engineering [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.94898.
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Saliva has a critical role in the maintenance of oral, dental and general health and well-being. Alteration(s) in the amount/quantity and/or quality of secreted saliva may induce the development of several oro-dental variations, thereby negatively-impacting overall quality of life. Diverse factors may affect the process of saliva production and quantity/quality of secretion, including medications, systemic or local pathologies and/or reversible/irreversible damage. Indeed, chemo- and/or radio-therapy, particularly, in cases of head and neck cancer, for example, are well-documented to induce serious damage and dysfunction to the radio-sensitive salivary gland tissue, resulting in hypo-salivation, xerostomia (dry mouth) as well as numerous other adverse intra−/extra-oral, medical and quality-of-life issues. Although a single governing mechanism of radiation-induced salivary gland tissue damage and dysfunction has not been yet elucidated, the potential for a synergy in radio-protection (mainly, and possible -reparation) via a combinatorial approach of mechanistically distinct strategies, has been suggested and explored over the years. This is, undoubtfully, in parallel to the ongoing efforts in improving the precision, safety and efficacy of radiotherapy protocols/outcomes, as well as in developing new technological and pharmaceutical alternatives, topics covered in this chapter.
Conference papers on the topic "Dental repair/regeneration"
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Keller, Christian, Andreas Kellersmann, Jens Friedrichs, and Joerg R. Seume. "Influence of Geometric Imperfections on Aerodynamic and Aeroelastic Behavior of a Compressor Blisk." In ASME Turbo Expo 2017: Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/gt2017-63556.
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Impacts of foreign objects can cause cracks and dents in airfoils, especially in the leading edge. The regeneration of high-pressure compressors blisks with current repair methods is often restricted to a local blending of these edges. This can cause significant changes in the airfoils’ geometrical properties, which in turn influence their aerodynamic and aeroelastic characteristics. Changes at the leading edge have a particularly strong influence on the airfoils’ aerodynamic properties. In order to be able to make an informed decision about if and how a repair should be performed, consequences have to be predicted in advance. To investigate their influence on the aerodynamic and aeroelastic behavior, typical blend repairs are applied to the geometry of a blisk in a 1.5-stage research axial compressor [1], which are representative in shape and size. Blisks (Blade-Integrated-diSK) are function integrated components, which are expected to have a high life span due to significant costs in design and production. Similar modifications are implemented at different radial heights of the blades, in order to investigate the influence of location and penetration depth of blend repairs. It is assured that only the blend repair region is modified while the rest of the blade stays in the original shape. Thus, a realistic change of the geometry is given. The numerical study presented here deals with the influence of geometric imperfections, blend repairs in particular, on the aerodynamic and aeroelastic behavior of the high pressure compressors blisks. Results show that blend repairs have an influence on the local pressure distribution as well as on the local flow turning. Even though the leading edge is reshaped during repair, performance degradation can be observed. Furthermore, the working range of the compressor stage is influenced by the blend-repairs, which is of great importance for safe operation. Finally, the local changes in aerodynamics and blade deformation influence the aeroelastic behavior. This influence depends on the investigated mode shape and the location of the modification. The closer the modification is located towards the tip, the more pronounced are the shifts in aerodynamic damping and aerodynamic stiffness. Low torsional mode shapes display the highest sensitivity to the modifications.