Journal articles on the topic 'Dengue'
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Bhavya, M., M. Ramya, N. Nagarjun, Nagarathna Amresh, and Balasubramanian Sathyamurthy. "Docking study of Selected Vinis vitifera seeds constituents on Dengue viral proteins – An In Silico approach." Indian Journal of Pharmaceutical and Biological Research 6, no. 04 (December 31, 2018): 25–31. http://dx.doi.org/10.30750/ijpbr.6.4.5.
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Dengue is a mosquito-borne systemic viral infection caused by any of the four antigenically related dengue viruses (DENV).The dengue virus belongs to the Flaviviridae family of viruses that cause diseases in humans.A virtual screening analysis of phytochemical structures with dengue virus protein targets has been carried out using a molecular docking approach with vins vinifera seeds. Grapes (Vinis vitifera) are believed to have health benefits due to their antioxidant activity and polyphenols. In this study we examined the binding affinities of 14 ligands with seven non structural Dengu viral proteins through In Silico methods like virtual screening and docking process which showed that compound F and compound N had high binding efficiencies with these proteins along with the type of hydrogen bonds and their respective amino acid residues at their docked sites.
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Hà, Văn Lực, Văn Trầm Tạ, and Văn Khoa Lê. "ĐẶC ĐIỂM LÂM SÀNG VÀ KẾT QUẢ ĐIỀU TRỊ SỐC SỐT XUẤT HUYẾT DENGUE Ở TRẺ DƯ CÂN, BÉO PHÌ TẠI CẦN THƠ." Tạp chí Y Dược học Cần Thơ, no. 74 (May 27, 2024): 180–86. http://dx.doi.org/10.58490/ctump.2024i74.2626.
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Đặt vấn đề: Trẻ em dư cân, béo phì có nguy cơ nhiễm virus Dengue cao hơn và là một trong những yếu tố có liên quan đến liên lượng tái sốc của sốt xuất huyết Dengue. Mục tiêu nghiên cứu: Khảo sát các đặc điểm lâm sàng và mô tả kết quả điều sốc sốt xuất huyết Dengue ở trẻ dư cân, béo phì tại Cần Thơ năm 2022-2024. Đối tượng và phương pháp nghiên cứu: Mô tả cắt ngang có phân tích trên 60 trẻ sốc sốt xuất huyết Dengue có dư cân, béo phì tại Cần Thơ năm 2022-2024. Kết quả: Trẻ từ 6 đến 12 tuổi chiếm tỷ lệ cao nhất (76,3%). Có 10 trường hợp sốc sốt xuất huyết Denuge nặng, chiếm 17%. Tổng lượng dịch truyền trung bình là 170,9 ± 58,7 ml/kg, thời gian truyền dịch trung bình là 35,0 ± 7,5 giờ. Có đến 55% trường hợp phải dùng cao phân tử. Có đến 29 trường hợp tái sốc, chiếm tỷ lệ 48,3%. Đa số bệnh nhân hồi phục sau khi được điều trị. Kết luận: Đa số bệnh nhi sốc sốt xuất huyết Dengue có dư cân, béo phì nhập viện tại Bệnh viện Nhi Đồng Cần Thơ đều hồi phục và khỏi bệnh.
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Martins, Hafra Kelly Pessoas, Pâmela Pereira Lima, Mara Glecia Costa Lacerda, Renata da Silva Santos Aquino, and Kelúria Brito Honório Torres. "DISTRIBUIÇÃO DOS CASOS NOTIFICADOS DE DENGUE NO ESTADO DO PIAUÍ." REVISTA FOCO 17, no. 6 (June 20, 2024): e5191. http://dx.doi.org/10.54751/revistafoco.v17n6-094.
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A dengue assume atualmente um papel proeminente entre as doenças arbovirais de relevância epidemiológica global. O presente estudo tem como objetivo descrever o número de notificações de dengue nos últimos cinco anos no estado do Piauí.Trata-se de uma pesquisa descritiva, transversal, de cunho quantitativo, realizada por meio de busca na base de dados DATASUS e Sinan, referentes às notificações de agravos compulsórios nos anos de 2020 a 2024, no estado do Piauí. Além disso, foi consultado o banco de dados da Scielo para embasar teoricamente a pesquisa, utilizando os descritores "dengues", "emergências" e "infecção pelo vírus da dengue", com a associação dos termos através dos operadores booleanos "and" e "or". Nos anos observados, foram identificadas 54521 notificações de casos de dengue em uma população de 3 milhões de habitantes. Evidencia-se a significativa distribuição da dengue no estado do Piauí, com o ano de 2022 apresentando a maior notificação. Esta rede de transmissão apresenta-se como um gráfico de ondulação, onde o fator determinante deste evento não é facilmente constatável através das notificações.Apesar da alta incidência da transmissão deste vírus, é imprescindível uma investigação minuciosa que correlacione essa incidência com fatores ambientais e climáticos, visando uma melhor compreensão da distribuição do vetor.
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Gubler, Duane J. "Dengue and Dengue Hemorrhagic Fever." Clinical Microbiology Reviews 11, no. 3 (July 1, 1998): 480–96. http://dx.doi.org/10.1128/cmr.11.3.480.
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SUMMARY Dengue fever, a very old disease, has reemerged in the past 20 years with an expanded geographic distribution of both the viruses and the mosquito vectors, increased epidemic activity, the development of hyperendemicity (the cocirculation of multiple serotypes), and the emergence of dengue hemorrhagic fever in new geographic regions. In 1998 this mosquito-borne disease is the most important tropical infectious disease after malaria, with an estimated 100 million cases of dengue fever, 500,000 cases of dengue hemorrhagic fever, and 25,000 deaths annually. The reasons for this resurgence and emergence of dengue hemorrhagic fever in the waning years of the 20th century are complex and not fully understood, but demographic, societal, and public health infrastructure changes in the past 30 years have contributed greatly. This paper reviews the changing epidemiology of dengue and dengue hemorrhagic fever by geographic region, the natural history and transmission cycles, clinical diagnosis of both dengue fever and dengue hemorrhagic fever, serologic and virologic laboratory diagnoses, pathogenesis, surveillance, prevention, and control. A major challenge for public health officials in all tropical areas of the world is to devleop and implement sustainable prevention and control programs that will reverse the trend of emergent dengue hemorrhagic fever.
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Ismaillya Noor, Roudhotul, Aryati Aryati, and Puspa Wardhani. "KETERKAITAN ANTIGEN NS1 INFEKSI VIRUS DENGUE DENGAN SEROTIPE VIRUS DENGUE." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 18, no. 2 (March 17, 2018): 87. http://dx.doi.org/10.24293/ijcpml.v18i2.1005.
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Dengue virus infection (DVI) currently is detected by using dengue virus NS1 antigen (NS1 Ag). The sensitivity of NS1 Ag is 27.8%–93.4%,but recent study of Kumarasamy the sensitivity of NS1 Ag is better than the virus isolation and polymerase chain reaction (PCR). This studyis focussed on the evaluation of the validity of Panbio Dengue Early Rapid for the diagnosis of DVI and the NS1 Ag sensitivity associated withdengue virus serotypes. The sera was obtained from 65 DVI patients which diagnosed by the clinicians. The resulted diagnosis was foundby serology tests (positive IgM/IgG antidengue/NS1 Ag ELISA) and 1997 WHO criteria as the gold standard, and which also found 35 nonDVI patients (typhoid fever, HAV, malaria, UTI, tuberculosis and bronchopneumonia). The samples were examined by Panbio Dengue EarlyRapid. PCR was performed on each positive serological test result to determine the dengue virus serotypes. The sensitivity and specificity ofPanbio Dengue Early Rapid was 49.2% and 100%. The PCR results of 65 sera showed positive PCR in 49.2% (positive NS1 Ag was 62.5%).Meanwhile, and negative PCR in 50.8% (positive NS1 Ag was 36.4%). The predominance of serotypes (positive NS1 Ag) were DEN-3 (37.5%),DEN-4 (28.1%), DEN-1 (21.9%) and DEN-2 (12.5%). The Panbio Dengue Early Rapid can be used as early detection of DVI, although itshould be used in conjunction with other dengue serological tests as well. Unfortunately there is still not enough evidence about the NS1 Agsensitivity associated with the dengue virus serotypes.
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Hapsari, Lutfiana Inda, Nonik Eka Martyastuti, and Erwin Lestyaningsih. "Implementasi Kompres Hangat pada Pasien Anak DHF (Dengue Haemorhagic Fever) dengan Hipertermi di Ruang Flamboyan RSUD Batang." Pena Medika Jurnal Kesehatan 12, no. 2 (January 4, 2023): 259. http://dx.doi.org/10.31941/pmjk.v12i2.2585.
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<p><strong>Latar belakang : </strong><em>Dengue Haemoragic Fever</em> (DHF) atau yang biasa disebut dengan penyakit Demam Berdarah Dengue (DBD) merupakan penyakit yang disebabkan karena infeksi virus dengue yang ditularkan melalui gigitan nyamuk Aedes aegepty yang dapat memicu terjadinya demam atau hipertermi (Nuryanti, dkk. 2022). Menurut WHO pada tahun 2019 jumlah kasus Dengu fever dilaporakan sebanyak 5,2 juta kasus. Demam Berdarah Dengue (DBD) di Indonesia hingga Juli 2019 mencapai 71.633 kasus dan 541 diantaranya meninggal dunia (Kemenkes,2020). Di Jawa Tengah, Pada tahun 2019 Kasus DBD tecatat sebanyak 2.846 kasus (Dinkes Jateng Prov, 2019). Sedangkan di kabupaten Batang kasus DBD awal pada Juni 2022 sebanyak 8 kasus dengan korban meninggal dunia sebanyak tiga orang. sebanyak (Dinkes Batang, 2022). <strong>Tujuan : </strong>Mampu menerapkan implementasi kompres hangat pada pasien anak dengan <em>Dengue Haemoragic Fever</em> (DHF) secara komprehensif.<strong> Metode : </strong>Metode yang digunakan dalam studi kasus ini adalah metode dekriptif dengan pendekatan studi kasus melalui pemberian asuhan keperawatan. <strong>Hasil : </strong>Setelah dilakukan implementasi kompres hangat pada pasien anak hipertermi dengan DHF selama 3x24 jam masalah hipertermi dapat teratasi. <strong>Simpulan : </strong>Kompres hangat dapat menrurunkan hipertermi pada anak<strong> </strong>dengan DHF.</p>
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Naeem, Muhammad, Aneela Shaheen, Saima Batool, Sara Rubab, Tehmina Saba, Tooa Riaz, and M. Arshad Mahmood. "DENGUE FEVER." Professional Medical Journal 21, no. 02 (December 6, 2018): 243–46. http://dx.doi.org/10.29309/tpmj/2014.21.02.1972.
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Background: Dengue is the most prevalent mosquito-born viral illness in theworld. Clinically dengue ranges from asymptomatic, non-febrile illness, classic dengue todengue hemorrhagic fever/dengue shock syndrome. Objective: Subjects & Methods: Thisstudy was included 79 patients conducted at Nawaz Sharif Social Sevurity Hospital, Lahoreduring the epidemic of dengue in Lahore from September 2011 to Dec 2011. Results: Twenty outof 79 patients suspected of dengue fever were dengue IgM positive. Male to female ratio was1.19: 1. Our study included 79 patients suspected of having dengue fever. Fever was the mostcommon symptom in these patients. Conclusions: Early identification of dengue with risk ofdeveloping hemorrhage is an important clinical objective. The morbidity and mortality can bereduced by appropriate and judicious treatment of dengue patients.
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Livingston, P. G., I. Kurane, L. C. Dai, Y. Okamoto, C. J. Lai, R. Men, S. Karaki, M. Takiguchi, and F. A. Ennis. "Dengue virus-specific, HLA-B35-restricted, human CD8+ cytotoxic T lymphocyte (CTL) clones. Recognition of NS3 amino acids 500 to 508 by CTL clones of two different serotype specificities." Journal of Immunology 154, no. 3 (February 1, 1995): 1287–95. http://dx.doi.org/10.4049/jimmunol.154.3.1287.
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Abstract Dengue virus infections are a major cause of morbidity and mortality in tropical and subtropical areas of the world. We analyzed dengue virus-specific CD8+ CD4- CTL at the clonal level to further understand the role of CD8+ CTL in dengue virus infections. Dengue virus-specific CD8+ CTL clones were established from lymphocytes of a dengue 4-immune adult. Three patterns of dengue serotype specificities were identified: 1) specific for dengue 4, 2) cross-reactive for dengue 2 and dengue 4 (subcomplex-specific); and 3) cross-reactive for all four dengue virus serotypes. Three dengue 4-specific clones and one dengue 2/dengue 4 cross-reactive clone were further analyzed. All four of the clones were HLA-B35 restricted and recognized NS3. The epitopes were mapped to amino acids (aa) 483 to 618 of NS3. The epitope was then defined by using synthetic peptides. Three dengue 4-specific clones and one dengue 2/dengue 4 cross-reactive clone recognized the same peptide (TPEGIIPTL) encompassing aa 500 to 508 of dengue 4 NS3. The peptide encompassing aa 500-508 of dengue 2 NS3 was recognized by a dengue 2/dengue 4 cross-reactive clone but was not recognized by the dengue 4-specific clones. Dengue 4-specific and dengue 2/dengue 4 cross-reactive clones used different TCR. These results indicate that CD8+ CTL clones that use different TCR and demonstrate two distinct serotype specificities recognize the same 9-mer peptide in the context of HLA-B35.
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A, Ravi Teja. "Sonographic Eye on Dengue during Clinical Evaluation and Early Diagnosis in Children." Pediatrics & Neonatal Biology Open Access 4, no. 2 (2019): 1–4. http://dx.doi.org/10.23880/pnboa-16000142.
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The study was done during epidemic of dengue in South India tertiary paediatric Hospital during 2019, for a period of one mon th. Role of ultrasound in early identification of dengue and its complications along with clinical and laboratory investigations. Ultrasound was performed on 112 patients (1 – 14 years) referred from dept. of paediatrics for ultrasound with features of dengu e and its complication and later confirmed the diagnosis with serology proven. 30 patients were serologically negative for dengue fever hence excluded from the study. Out of 92 serologically positive cases 31 cases visited hospital at early stage and under gone ultrasound during 2/3 rd day and 5/7 th day of fever. During 2/3 rd day ultrasound showed as almost all showed gall bladder wall thickening and pericholecystic fluid (in different patterns), 32.5% had hepatomegaly, 16.12% had splenomegaly and 19.35% righ t minimal pleural effusion, 3.25% left plural effusion. Follow - up ultrasound on fifth to seventh day revealed ascites in 93.5%, hepatomegaly in 90.3%, right plural effusion 80.6%, left pleural effusion in 41.9% and pericardial effusion in 29%. Of the 61 pa tients who underwent the study on fifth to seventh day of fever for the first time almost all had gall bladder wall thickening, 95.0%had hepatomegaly, 27.8% had splenomegaly, 96.7% had ascites, 95.08% had right pleural effusion, 75.4% had left pleural effu sion and 22.9% had pericardial fluid. To conclude, in an epidemic of dengue, ultrasound features of thickened gall bladder wall, pleural effusion heaptomegaly and ascites should strongly favour the diagnosis of dengue fever.
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Cabezas, César, Femando Donaires, and Paquita Garcla. "Dengue." Diagnóstico 56, no. 1 (December 13, 2018): 37–44. http://dx.doi.org/10.33734/diagnostico.v56i1.121.
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Desde su ingreso al Perú en 1990, el dengue sigue constituyendo y cada vez más un serio problema de salud pública. Esta enfermedad es causada por el virus del dengue que tiene 4 serotipos, además de subtipos en cada serotipo y el Aedes aegypti es el principal vector, que está presente en la costa desdeTumbes hasta Arequipa y su ubicuidad está en razón a determinantes sociales y ambientales. La OMS ha instaurado una nueva clasificación de la enfermedad como dengue con o sin signos de alarma y dengue grave, lo cu.al está facilitando tanto el diagnóstico y la orientación para el manejo. El control vectorial del Aedes aegypti es fundamental en la prevención y control del dengue.
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Thomas, Jessy, Priya Thomas, and Chinnu Reeba George. "Neonatal dengue." International Journal of Contemporary Pediatrics 4, no. 6 (October 24, 2017): 2234. http://dx.doi.org/10.18203/2349-3291.ijcp20174765.
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Dengue infection is possible in all three trimesters of pregnancy. Dengue during pregnancy is associated with several neonatal complications such as perinatal death, miscarriage, low birth weight and preterm delivery. This is a case report of perinatal transmission of dengue in a baby who was born by an emergency caesarean section. The female baby was diagnosed with dengue fever as her dengue NS1 and ELISA tests were positive like her mother. Early recognition of congenital dengue will significantly reduce maternal and infant mortality. Proper management and supportive treatment is required for thrombocytopenia and hemorrhagic manifestations in dengue fever.
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Dương, Văn Hiếu, Minh Phương Nguyễn, Quang Khải Trần, Thị Ngọc Triệu Trần, and Đình An Huỳnh. "NGHIÊN CỨU TÌNH HÌNH NHIỄM VI RÚT DENGUE VÀ MỘT SỐ YẾU TỐ LIÊN QUAN Ở BỆNH NHI SỐT XUẤT HUYẾT DENGUE NẶNG TẠI BỆNH VIỆN NHI ĐỒNG CÂN THƠ NĂM 2022-2023." Tạp chí Y Dược học Cần Thơ, no. 66 (November 3, 2023): 22–28. http://dx.doi.org/10.58490/ctump.2023i66.1399.
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Đặt vấn đề: Bệnh sốt xuất huyết Dengue là bệnh nhiễm trùng cấp do siêu vi Dengue gây ra và mỗi týp khác nhau sẽ gây mức độ nặng khác nhau. Mục tiêu nghiên cứu: 1). Tỷ lệ nhiễm vi rút Dengue. 2). Đánh giá kết quả điều trị. 3). Mối liên quan týp vi rút Dengue với lâm sàng, cận lâm sàng. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang có phân tích trên 84 bệnh nhi điều trị tại Bệnh viện Nhi đồng Cần Thơ và được chẩn đoán sốt xuất huyết Dengue nặng theo tiêu chuẩn của Bộ Y tế năm 2019. Kết quả: Týp vi rút Dengue 2 (46,4%), Dengue 1(10,7%), Dengue 4 (4,8%), Dengue 3 (0%). Kết quả chung điều trị khỏi 97,7%, tử vong 2,3%, triệu chứng nôn ói 83.3% (p=0,01), đau bụng 82,9% (p=0,02), gan to 81,4% (p=0,03) thường gặp ở týp Dengue 2 cao hơn các týp khác. Týp Dengue 2 có tăng creatinine 57,6 ± 16,6 (p=0,046), giảm bạch cầu 3645 ± 317,7 (p=0,043) và tăng dung tích hồng cầu 46,9 ± 4,3 (p=0,005). Týp Dengue 1 và Dengue 4 tăng nồng độ ure cao hơn týp Dengue 2 với 3.9 ± 1.9 (p=0,046). Kết luận: Týp Dengue 2 chiếm tỷ lệ cao nhất với 46,4%, tỷ lệ điều trị khỏi chiếm 97,7%. Nhóm Dengue 1 và Dengue 4 nồng độ ure tăng (3.9 ± 1.9) cao hơn so với nhóm Dengue 2. Týp Dengue 2 có tăng creatinine (57,6 ± 16,6), bạch cầu giảm (3645 ± 317,7), dung tích hồng tăng (46,9 ± 4,3) cao hơn so với Dengue 1 và Dengue 4. Triệu chứng lâm sàng như nôn ói (83,3%), (đau bụng 82,9%), gan to (81,4%) ở Dengue 2 cao hơn Dengue 1 và Dengue 4.
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Marvianto, Denni, Oktaviani Dewi Ratih, and Katarina Frenka Nadya Wijaya. "Infeksi Dengue Sekunder: Patofisiologi, Diagnosis, dan Implikasi Klinis." Cermin Dunia Kedokteran 50, no. 2 (February 1, 2023): 70–74. http://dx.doi.org/10.55175/cdk.v50i2.518.
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Infeksi dengue sekunder merupakan infeksi dengue yang terjadi kali kedua. Infeksi kedua dengan serotipe berbeda dapat menyebabkanpenyakit dengue yang lebih berat. Penelitian menunjukkan bahwa 98% kasus dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) merupakan infeksi dengue sekunder. Patofisiologi yang menjadikan infeksi dengue sekunder lebih berat belum sepenuhnya dipahami, diduga berkaitan dengan mekanisme antibody dependent enhancement (ADE). Membedakan infeksi dengue primer dan sekunder penting agar dokter dan tenaga kesehatan mampu memprediksi prognosis dan keluaran klinis pasien.
Dengue secondary infection is the second dengue infection. A second infection with different serotype tend to be more severe. Data shown that 98% cases of dengue hemorrhagic fever/ dengue shock syndrome (DHF/DSS) are dengue secondary infection. The pathophysiology of more severe cases is not fully understood; it is suspected to be related to antibody dependent enhancement (ADE) mechanism. Differentiating primary and secondary dengue infection is important to predict patient’s prognosis and clinical outcome
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Arun, Prachi, Lata Sangwan, and Amit Munjal. "Comparative Study of Hematological and Biochemical Changes in Patients Infected by Dengue Fever at Tertiary Care Hospital at Fatehabad, Haryana." Indian Journal of Medical and Health Sciences 6, no. 2 (December 15, 2019): 53–57. http://dx.doi.org/10.21088/ijmhs.2347.9981.6219.1.
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Introduction: Dengue viral infections are the most important mosquito-borne diseases of the Indian subcontinent and have become a major global public concern. World Health Organization (WHO) has estimated about 50 million cases of dengue infection every year worldwide. This disease caused by dengue ranges from a relatively minor febrile illness to a lifethreatening condition characterized by extensive capillary leak. Apoptotic hepatocytes are found to be colocalized with dengue virus infected hepatocytes, suggesting that hepatocytes are the major site of dengue virus replication in the liver. Objective: To evaluate hematological and biochemical changes in serologically proven patients with clinical manifestations of dengue fever. Materials and Methods: The present study has been carried out in General Hospital Fatehabad, District Fatehabad, Haryana. Fifty patients suffering from fever were included in study. Blood samples of twentyfive febrile individuals belonging to each group, seronegative for Dengue (Group A) and seropositive Dengue subjects (Group B) were taken. Hb, TLC, Platelet count, SGOT and SGPT estimations were done of febrile patients seronegative for Dengue (Group A) and seropositive Dengue patients (Group B). Result: It was found that in seropositive dengue patients the Hb values are low as compared to seronegative dengue patients, i.e. Hb ranging from 5.8–11.2 gm/dl in seropositive dengue patients and 10.2–15.6 gm/dl in seronegative dengue patients. TLC range in seronegative dengue patients is 5800– 10800/cumm and in seropositive dengue patients it is recorded as 1300–4800/cumm. The study also depicted that platelet count is comparatively low among seropositive dengue patients, i.e. 20,000–80,000 cells/cumm as compared to seronegative dengue patients in which platelet count ranges from 1,58,000– 3,32,000 cells/cumm. SGOT and SGPT values are raised in seropositive dengue patients as compared to seronegative dengue patients with SGOT ranging between 68–540 IU/L among seropositive dengue patients and 8–40 IU/L among seronegative dengue patients. The values of SGPT range from 12–30 IU/L in seronegative dengue patients and 63–480 IU/L in seropositive dengue patients. Conclusion: Considering the results, it was concluded that in seropositive dengue patients Hb and platelet levels are low as compared to seronegative dengue patients whereas TLC levels show a decrease in seropositive Dengue patients but sometimes it may also be increased due to other bacterial infections. Biochemical markers, i.e. SGOT and SGPT were higher in seropositive dengue patients as compared to seronegative dengue patients.
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Khan, Wasil, Bacha Amin Khan, Zar Khan, Abid ur Rehman, Mohammad Akbar, and Ishtiaq Ali Khan. "DENGUE FEVER;." Professional Medical Journal 24, no. 10 (October 6, 2017): 1466–70. http://dx.doi.org/10.29309/tpmj/2017.24.10.712.
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Introduction: Dengue fever is arboviral infection transmitted from infected personto non-infected one by mosquitoes Aedes Aegypti or Aedes albopectis. All four serotypes (DEN-1, DEN-2, DEN-3 & DEN-4) can cause the clinical manifestations of disease. Dengue infectioncan cause acute febrile illness, dengue hemorrhagic fever (DHF) and dengue shock syndrome(DSS). About 50-100 million cases of dengue fever reported annually worldwide in which 0.5million may need admission. Overall mortality of dengue fever is 3%. The diagnosis of dengueis established by classical clinical features along with specific investigations like PCR, detectionof dengue NS1 antigen or IgM or IgG antibodies in the blood of infected person. Dengue isendemic in most part of our country and can become epidemics on and off. Objectives: Tostudy the pattern and mortality of Dengue fever during epidemic and post epidemic years inSwat. Setting: This study was conducted in Medical Department of Saidu Group of TeachingHospital, Swat. Period: Aug 2013 to November, 2016. Patients and method: Patients sufferingfrom acute febrile illness with features suggestive of Dengue fever were included in the study.Clinical criteria for initial diagnosis directed the subsequent diagnostic work up. Dengue wasconfirmed in these patients by either Dengue NS1 or Ig M antibodies in their blood. Writtenconsent for participation in study was taken from all the included patients. Formal permissionwas taken from Institutional Review Board of the institution to perform this study. The clinical andlaboratory data were recorded on a proforma and analyzed using SPSS 20. Results: Among5569 patients, 3834 (68.85 %) were male and 1735 (31.15%) were female. The mean age ofthe patients was 30 years SD 15.20. The most common age group that suffered with Denguefever was the adult age group (13-30 years). Dengue Hemorrhegic Fever was diagnosed in2543 (45.6%) patients and 50 (0.89 %) had features of DSS. A total 5018 (90.1 %) patients werecompletely cured while 37 (0.66 %) patients died. The overall mortality was 0.66%. Patientswith Dengue fever presented to the hospital though out the year but more than 50% of caseswere reported in the month of September. Conclusion: Adult age group and male gender ismost commonly affected by Dengue fever. Dengue fever was endemic in Swat valley and it canbecome cyclic epidemic in post epidemic years. Dengue fever can claim so many preciouslives if proper preventive measures were not taken in future.
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Nkenfou, Celine Nguefeu, Nadine Fainguem, Félicitée Dongmo-Nguefack, Laeticia Grace Yatchou, Joel Josephine Kadji Kameni, Elise Lobe Elong, Amidou Samie, William Estrin, Paul Ndombo Koki, and Alexis Ndjolo. "Enhanced passive surveillance dengue infection among febrile children: Prevalence, co-infections and associated factors in Cameroon." PLOS Neglected Tropical Diseases 15, no. 4 (April 16, 2021): e0009316. http://dx.doi.org/10.1371/journal.pntd.0009316.
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Dengue virus (DENV) causes a spectrum of diseases ranging from asymptomatic, mild febrile to a life-threatening illness: dengue hemorrhagic fever. The main clinical symptom of dengue is fever, similar to that of malaria. The prevalence of dengue virus infection, alone or in association with other endemic infectious diseases in children in Cameroon is unknown. The aim of this study was to determine the prevalence of dengue, malaria and HIV in children presenting with fever and associated risk factors. Dengue overall prevalence was 20.2%, Malaria cases were 52.7% and HIV cases represented 12.6%. The prevalence of dengue-HIV co-infection was 6.0% and that of Malaria-dengue co-infection was 19.5%. Triple infection prevalence was 4.3%. Dengue virus infection is present in children and HIV-Dengue or Dengue- Malaria co-infections are common. Dengue peak prevalence was between August and October. Sex and age were not associated with dengue and dengue co-infections. However, malaria as well as HIV were significantly associated with dengue (P = 0.001 and 0.028 respectively). The diagnosis of dengue and Malaria should be carried out routinely for better management of fever.
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Manoharan, Rakesh, Umapathy Pasupathy, Latha Ravichandran, Elayaraja Sivaprakasam, Srinivasan V., and Krishna Sameera G. "Cytokine IL-12, Dengue in children: analysis of a unique relationship." International Journal of Contemporary Pediatrics 5, no. 3 (April 20, 2018): 1109. http://dx.doi.org/10.18203/2349-3291.ijcp20181552.
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Background: Dengue is a mosquito borne viral infection caused by one of the four serotypes of dengue viruses (DENV1-DENV4). The consequences of DENV infection range from asymptomatic condition, dengue fever (DF), or severe forms, such as dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). The host immune responses have been considered as the major factor responsible for dengue pathogenesis. In this study, the cytokine IL-12 is reviewed for its utility as potential biomarker of severe dengue disease.Methods: 120 children of paediatric age group with either dengue NS1 antigen or dengue IgM positive were included. Cases were classified as uncomplicated dengue (dengue without warning signs) and complicated dengue (dengue with warning signs and severe dengue). Clinical features and IL-12 (ELISA KIT) levels were analyzed in the study population.Results: Analysis of clinical features among the study groups revealed children with complicated dengue had persistent vomiting (95%), abdominal pain (80%), decreased urine output (50%), bleeding manifestations (83.3%), Hepatomegaly (70%) Haemoconcentration with concurrent thrombocytopenia (93.3%), altered coagulation profile (28.3%), ICU stay (54.7%), leukocytosis (15%), leucopoenia (66.6%) normal leucocytes, (18.4%). Analysis of IL-12 levels revealed children with complicated dengue showed significant elevation compared to controls and uncomplicated dengue.Conclusions: In our study IL-12 levels were significantly higher in complicated dengue patients in comparison with uncomplicated dengue patients as well as normal control population.
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Manjunath, V. G., Sruthi Balla, and Jagadish Kumar. "Serum ionic calcium levels and hypocalcemia in dengue fever in children and its correlation with its severity: case control study." International Journal of Contemporary Pediatrics 6, no. 3 (April 30, 2019): 1289. http://dx.doi.org/10.18203/2349-3291.ijcp20192030.
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Background: Dengue fever (DF) is a major health problem, 90% of dengue hemorrhagic fever (DHF) occurring in children <5 years and mortality of 2.5%. Abnormalities like metabolic acidosis, hyponatremia and hypocalcemia can occur in severe dengue especially in dengue shock patients. Alterations in calcium homeostasis, may play a role in the pathogenesis of dengue shock. Objectives is to evaluate serum ionic calcium (Ca2+) levels in children aged 1-18yrs with dengue fever and correlate it with severity and outcomeMethods: The study was prospective hospital based case-control study. Case group had 75 children with dengue fever with equal number of controls. Cases were classified according to WHO classification. Serum Ca2+ levels were estimated within 24 hours of admission.Results: Majority of children with dengue were in the age-group of 6-15 years (71.4%). Out of 75 cases,16% were dengue without warning signs, 54.7% dengue with warning signs and 29.3% were severe dengue cases. Mean Ca2+ level (in mmol/l) was 1.2009 (±0.09) among controls and 1.0911 (±0.10) in dengue cases (p=0.0001). Mean Ca2+ level in dengue without warning signs was 1.0950 mmol/l, dengue with warning signs was 1.1088 mmol/l and severe dengue was 1.0559 mmol/l. Mean Ca2+ level in severe dengue was significantly lower compared to dengue with warning signs (p=0.04). Hypocalcemia was seen in 56% of dengue cases but only 14% among controls. Seven children with severe dengue who died had hypocalemia.Conclusions: Hypocalcemia is common in dengue fever. Lower levels of ionic calcium correlate with severity of dengue illness and may be considered as a prognostic indicator of poor outcome.
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Lim, Jacqueline Kyungah, Pornthep Chanthavanich, Kriengsak Limkittikul, Jung-Seok Lee, Chukiat Sirivichayakul, Kang Sung Lee, Sl-Ki Lim, In-Kyu Yoon, and Weerawan Hattasingh. "Clinical and epidemiologic characteristics associated with dengue fever in 2011–2016 in Bang Phae district, Ratchaburi province, Thailand." PLOS Neglected Tropical Diseases 15, no. 6 (June 30, 2021): e0009513. http://dx.doi.org/10.1371/journal.pntd.0009513.
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Background Dengue is a major public health problem in Thailand, but data are often focused on certain dengue-endemic areas. Methods: To better understand dengue epidemiology and clinical characteristics in Thailand, a fever surveillance study was conducted among patients aged 1–55 years, who presented with non-localized febrile illness at Bang Phae Community Hospital in Ratchaburi province, Thailand from October 2011 to September 2016. Results Among 951 febrile episodes, 130 were dengue-confirmed. Individuals aged 10–14 years were mostly affected, followed by those 15–19 years-of-age, with about 15% of dengue-confirmed cases from adults 25 years and older. There were annual peaks of dengue occurrence between June-November. Most prevalent serotype in circulation was DENV-2 in 2012, DENV-3 in 2014, and DENV-4 & -3 in 2015. Among dengue cases, 65% were accurately detected using the dengue NS1 RDT. Detection rate was similar between secondary and primary dengue cases where 66% of secondary vs. 60% of primary dengue cases had positive results on the NS1 RDT. Among dengue cases, 66% were clinically diagnosed with suspected dengue or DHF, prior to lab confirmation. Dengue was positively associated with rash, headache, hematemesis and alterations to consciousness, when compared to non-dengue. Dengue patients were 10.6 times more likely to be hospitalized, compared to non-dengue cases. Among dengue cases, 95 were secondary and 35 were primary infections. There were 8 suspected DHF cases and all were identified to be secondary dengue. Secondary dengue cases were 3.5 times more likely to be hospitalized compared to primary dengue cases. Although the majority of our dengue-positive patients were secondary dengue cases, with few patients showing manifestations of DHF, our dengue cases were mostly mild disease. Even among children < 10 years-of-age, 61% had secondary infection and the rate of secondary infection increased with age. Conclusion While the majority of dengue-confirmed cases were children, almost three-quarters of dengue-confirmed cases in this study were secondary dengue. Our study results consistent with previous data from the country confirm the hyperendemic transmission of DENV in Thailand, even in the non-epidemic years. With various interventions becoming available for dengue prevention and control, including dengue vaccines, decision-making on future implementation strategies should be based on such burden of disease data.
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Charisma, Acivrida Mega, Elis Anita Farida, and Farida Anwari. "Diagnosis Dengue melalui Deteksi Antibodi Imunoglobulin G Spesifik dalam Sampel Urine dengan Teknik ELISA." ASPIRATOR - Journal of Vector-borne Disease Studies 12, no. 1 (June 29, 2020): 11–18. http://dx.doi.org/10.22435/asp.v12i1.2366.
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Abstract. Dengue is a disease caused by dengue virus infection. Diagnosis of the disease is often difficult to be upheld just by the symptoms. Therefore, laboratory diagnostics is required. The general objective of this study was to detect dengue IgG in serum samples with rapid tests and in urine samples of suspected dengue patients using ELISA. The procedure of this study consisted of three stages. First, collecting urine samples from healthy individuals and collecting blood and urine samples from suspected dengue patients; second, examining dengue IgG in serum samples of suspected dengue patients with rapid tests; and third, examining dengue-specific IgG in urine samples from suspected dengue patients and from healthy individuals with ELISA technique. Data analyzed using experimental analytics to determine the cut off point used to interpret laboratory diagnostic results. The results showed that patients with positive serum dengue IgG test at the same time also showed positive results on the examination of dengue-specific IgG in their urine samples while patients with negative serum at the same time showed negative results on the examination of dengue-specific IgG in urine samples. Dengue-specific IgG examination in urine samples with ELISA technique can be used as an alternative examination in establishing the diagnosis of dengue, in which urine samples are taken from patients with more than 4 days fever.
Keywords: Dengue, IgG, Urine, ELISA
Abstrak. Dengue merupakan penyakit yang disebabkan virus dengue. Diagnosis penyakit ini sering sulit ditegakkan jika hanya melihat dari gejala. Oleh karena itu, diperlukan pemeriksaan laboratorium untuk penegakkan diagnosis. Tujuan umum penelitian ini adalah untuk mendeteksi IgG dengue dalam sampel serum dengan rapid tes dan pada sampel urine pasien terduga dengue dengan menggunakan metode ELISA. Prosedur penelitian ini terdiri dari tiga tahap. Pertama, pengumpulan sampel urine individu sehat dan pngumpulan sampel darah dan urine pada pasien terduga dengue; kedua, pemeriksaan IgG dengue dalam sampel darah pasien terduga infeksi dengue dengan rapid tes; dan ketiga, pemeriksaan IgG spesifik dengue pada sampel urine pasien terduga dengue dengan teknik ELISA, yang sebelumnya sudah dikelompokkan sesuai dengan hasil pemeriksaan IgG dengue pada sampel serum dengan rapid tes, dan pemeriksaan IgG spesifik dengue sampel urine individu sehat dengan teknik ELISA. Analitik eksperimental digunakan untuk menentukan cut off dari data yang kemudian digunakan untuk menafsirkan hasil diagnostik laboratorium. Hasil penelitian menunjukkan bahwa pada pasien dengan hasil pemeriksaan IgG dengue serum positif menunjukkan hasil positif juga pada pemeriksaan IgG spesifik dengue pada sampel urinnya, sedangkan pada hasil pemeriksaan serum yang negatif menunjukkan hasil negatif pula pada pemeriksaan IgG spesifik dengue di sampel urinnya. Pemeriksaan IgG spesifik dengue pada sampel urine dengan teknik ELISA dapat digunakan sebagai pemeriksaan alternatif dalam penegakan diagnosis dengue, di mana sampel urine diambil dari pasien dengan demam lebih dari 4 hari.
Kata Kunci: Dengue, IgG, Urine, ELISA
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Edelman, Robert. "Dengue and Dengue Vaccines." Journal of Infectious Diseases 191, no. 5 (March 2005): 650–53. http://dx.doi.org/10.1086/427784.
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Sigera, Chathurani, Chaturaka Rodrigo, Nipun L. de Silva, Praveen Weeratunga, Deepika Fernando, and Senaka Rajapakse. "Direct costs of managing in-ward dengue patients in Sri Lanka: A prospective study." PLOS ONE 16, no. 10 (October 8, 2021): e0258388. http://dx.doi.org/10.1371/journal.pone.0258388.
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Introduction The cost in managing hospitalised dengue patients varies across countries depending on access to healthcare, management guidelines, and state sponsored subsidies. For health budget planning, locally relevant, accurate costing data from prospective studies, is essential. Objective To characterise the direct costs of managing hospitalised patients with suspected dengue infection in Sri Lanka. Methods Colombo Dengue Study is a prospective single centre cohort study in Sri Lanka recruiting suspected hospitalised dengue fever patients in the first three days of fever and following them up until discharge. The diagnosis of dengue is retrospectively confirmed and the cohort therefore has a group of non-dengue fever patients with a phenotypically similar illness, managed as dengue while in hospital. The direct costs of hospital admission (base and investigation costs, excluding medication) were calculated for all recruited patients and compared between dengue and non-dengue categories as well as across subgroups (demographic, clinical or temporal) within each of these categories. We also explored if excluding dengue upfront, would lead to an overall cost saving in several hypothetical scenarios. Results From October 2017 to February 2020, 431 adult dengue patients and 256 non-dengue fever patients were recruited. The hospitalisation costs were USD 18.02 (SD: 4.42) and USD 17.55 (SD: 4.09) per patient per day for dengue and non-dengue patients respectively (p>0.05). Laboratory investigations (haematological, biochemical and imaging) accounted for more than 50% of the total cost. The costs were largely homogenous in all subgroups within or across dengue and non-dengue categories. Excluding dengue upfront by subsidised viral genomic testing may yield overall cost savings for non-dengue patients. Conclusion As non-dengue patients incur a similar cost per day as the dengue patients, confirming dengue diagnosis using subsidised tests for patients presenting in the first three days of fever may be cost-efficient.
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Bose, Sayani, Feradica D. Laloo, Alisha Acharya, Bishal Gupta, Alex George, and Bhaswati Bandopadhyay. "A comparative study of clinical symptoms, demographic characteristics and laboratory parameters among primary and secondary dengue cases in a tertiary care hospital in Kolkata." IP International Journal of Medical Microbiology and Tropical Diseases 10, no. 1 (April 15, 2024): 29–33. http://dx.doi.org/10.18231/j.ijmmtd.2024.006.
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Dengue, an arthropod borne viral disease which is transmitted to humans through the bite of infected Aedes mosquitoes, can result in a range of clinical presentations from mild febrile illness like dengue fever (DF) to severe presentations like dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) which can turn fatal.While majority of primary dengue cases are asymptomatic/ mild symptomatic, secondary dengue infected cases usually have more complications and require critical care support.To find out proportion of Dengue IgG among NS1 reactive cases, study their clinical-demographic profiles and to find out the prevalent dengue serotypes.Blood collected from patients suffering from acute febrile illness less than 5 days and more than 5 days duration were tested for Dengue NS1and Dengue IgM respectively. Samples reactive for Dengue NS1 were further tested for dengue IgG by ELISA and dengue serotyping by RT-PCR. Results obtained were analysed and interpreted.Out of 2286 blood samples suspected for Dengue during the study period (March 2021 to February 2022), only 134 samples were NS1 reactive and amongst them, 21 (16%) had early detection of IgG antibodies while the rest 113(84%) cases were primary dengue infection. The predominant serotype was DENV-3.It is evident that patients who suffer from Secondary Dengue infections require more supervision and critical care support. This highlights the importance of Dengue IgG detection in the early phase of the disease in order to predict the complications of dengue which can save many more lives. Nevertheless, Primary dengue infections can also be severe, hence should be monitored closely under supervision. Molecular surveillance may help to predict large scale outbreaks of dengue if regional shifts in the predominantly circulating serotypes are detected during the early phase of the dengue season.
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Kumar, Alok, Marquita Gittens-St. Hilair, Vincent Jason, Christian Ugwuagu, and Kandamaran Krishnamurthy. "The clinical characteristics and outcome of children hospitalized with dengue in Barbados, an English Caribbean country." Journal of Infection in Developing Countries 9, no. 04 (April 15, 2015): 394–401. http://dx.doi.org/10.3855/jidc.5566.
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Introduction: Although dengue is endemic in all English-speaking Caribbean countries, there are no published studies on the clinical presentations and outcomes of children hospitalized with dengue from this region. This study aims to assess the clinical charcteristics and the outcome in children hospitalized with dengue. Methods: This was a population-based prospective study of all the children hospitalized with confirmed dengue in 2009 in Barbados. All children suspected to have dengue were routinely screened for dengue infection and underwent routine blood tests. Relevant data was extracted from their case files at the time of their discharge from the hospital. Results: Of the 199 children who were hospitalized with suspected dengue, 115 (58%) were confirmed. The overall incidence rate of dengue among children that required hospitalization was 2.1/1,000 children. Besides the typical clinical features of dengue, 64 children hospitalized with confirmed dengue also presented with gastrointestinal manifestations (56%), 39 with respiratory manifestations (51%), 11 with hepatic manifestations (10%), 8 with neurologic manifestations (7%), and 7 with cardiovascular manifestations (6%). Twenty (17.4%) children hospitalized with confirmed dengue met the criteria for the diagnosis of severe dengue. The other 82.6% had uncomplicated or non-severe (53.9% had dengue and 28.7% had dengue with warning signs) forms of dengue. The case fatality rate in this series was 1.7%. Conclusions: Less than a third of all the children with confirmed dengue required hospitalization. Atypical clinical manifestations were common, and only a minority of these children had severe dengue. Overall, the case fatality rate for dengue in this select population of children hospitalized with dengue was low.
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Kartika Sari, Sri, and Aryati Aryati. "DIAGNOSIS JANGKITAN (INFEKSI) VIRUS DENGUE DENGAN UJI CEPAT (RAPID TEST) IgA ANTI-DENGUE." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 17, no. 2 (March 17, 2018): 81. http://dx.doi.org/10.24293/ijcpml.v17i2.1020.
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Dengue IgM, IgG Capture ELISAs and NS1 Ag ELISA become the most widely used serological methods for dengue diagnosis untilnow. Previous studies reported a possible use of IgA antibodies for dengue virus as a new serologic marker to make dengue infectionactive. In the present study, the performance of IgA anti-dengue rapid test as a new marker of dengue infection was assessed. In thisstudy, the sera were obtained from 30 dengue virus infection patients and 30 non dengue virus infection patients. Thirty dengue pairedsera were collected twice, at the time of hospital admission (acute) and at discharge (convalescent). All sera samples were characterizedusing dengue reference ELISAs (NS1 Ag, Dengue IgM and IgG capture ELISAs). The results of IgA anti-dengue rapid test were comparedwith the corresponding dengue reference tests. The sensitivity and specificity of IgA anti-dengue rapid test respectively were 78.3% (95%CI: 65.5–87.5%), and 73.3% (95% CI: 55,6–85,8%). Meanwhile, from acute sera, sensitivity of IgA anti-dengue rapid test was 83.3%(95% CI: 64.5–93.7), higher than IgM (73.3%, 95% CI: 53.8–87.0), IgG (66.7%, 95% CI: 47.1–82.1) and NS1 Ag ELISAs (60%,95% CI: 40.7–76.8). Positive IgA anti-dengue rapid test results in acute sera was higher in the secondary (91%) than primary infection(57%). IgA anti-dengue rapid test can be considered as a new marker for dengue infection, because it gives a high sensitivity, especiallyin the acute phase and in the secondary infections as well.
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Soegijanto, Soegeng, Dian Dwi Sary, Budi Setiawan, and Atsushi Yamanaka. "The Role Activity of Complement, TNFα & IL12 in Pathogenesis Dengue Virus." Indonesian Journal of Tropical and Infectious Disease 1, no. 1 (April 1, 2010): 44. http://dx.doi.org/10.20473/ijtid.v1i1.3723.
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Dengue Virus infection is always found in some part of the world especially South East Asia including Indonesia. The pathogenesis of Dengue Virus infection is still controversial. The aim of this study is to analyze the role complement activity, TNFα & IL12 in Dengue Virus infection especially in pathogenesis of Dengue Virus infection. Cross sectional study had been done since February 2009 in Dr. Soetomo Hospital Surabaya. Blood Sera of Dengue Virus infection were collected from Dengue Fever, and Dengue Hemorrhagic Fever patient who had been care in Paediatric. Dengue patients and time schedule for taking blood sample for examination CH50, TNFα & IL12 as follow: on the first day on admission, the second day, the third day. Study groups of patients as follow: Dengue Fever, 36; Dengue Hemorrhagic Fever grade I, 37; Dengue Hemorrhagic Fever grade II, 10; Dengue Hemorrhagic Fever grade III, 18; Dengue Hemorrhagic Fever grade IV, 6. In this study found that the higher activity complement which lower level CH50 was more identified on Dengue Shock Syndrome and Dengue Hemorrhagic Fever grade III than Dengue Fever cases. A concept of our study was focusing on manifestation of vascular leakage, measurement of complement activity CH50, TNFα & IL12 and clinical manifestation Dengue Hemorrhagic Fever. The examination of TNFα & IL12 in our study supported the role the activity complement. The conclusion are measurement CH50, TNFα & IL12 can be used as a predictive factor of the degree of Dengue Virus infection
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Chouhan, Dr Arpan Singh. "Dengue Encephalitis." Journal of Medical Science And clinical Research 04, no. 12 (December 30, 2016): 14287. http://dx.doi.org/10.18535/jmscr/v4i12.02.
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Joy, Jaiby. "Dengue Fever." Indian Journal of Communicable Diseases 2, no. 2 (2016): 81–85. http://dx.doi.org/10.21088/ijcd.2395.6631.2216.7.
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Desi Irawati, Adinda, and Hotimah Masdan Salim. "Dengue Vaccine Development at the Dengue virus serotypes." International Islamic Medical Journal 1, no. 1 (December 9, 2019): 9–15. http://dx.doi.org/10.33086/iimj.v1i1.1360.
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Dengue hemorrhagic fever (DHF) is a disease caused by dengue virus (DENV1-4) and is transmitted by the Aedes aegypti mosquito. However, in 2015, official data from the member countries, WHO reported more than 3.2 million cases, including 10,200 severe dengue cases and 1181 deaths. The protein encoded by the genome of dengue virus. Major structural and non structural proteins making up the genome of dengue. From genomic data several studies found that mechanism of vaccine that can use in dengue virus. Several vaccines was establish in the world for example Live attenuated Vaccine, Chimera Vaccine, Subunit Vaccine, DNA vaccines DENV, Activated DENV Vaccine - Whole Virus Particles, Activated DENV Vaccine - Recombinant Subunit DENV, and DENV Vaccine 5.
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Marbun, Farida. "PENGARUH PARTISIPASI MASYARAKAT DALAM GERAKAN 3M (MENGURAS, MENUTUP DAN MENGUBUR) TERHADAP PENANGGULANGAN DEMAM BERDARAH DENGUE DI KELURAHAN TANJUNG PENYEMBAL KOTA DUMAI TAHUN 2020." Jurnal Penelitian Kesmasy 4, no. 2 (April 28, 2022): 21–27. http://dx.doi.org/10.36656/jpksy.v4i2.873.
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This study aims to analyze the Effect of Community Participation (Willingness, Capability and Opportunities) in the 3M Reservoir Movement for Management of Dengue Hemorrhagic Fever (DHF) in Tanjung Penyembal Village, Sungai Sembilan District, Dumai City in 2020. The study used was a cross-sectional study using an explanatory research approach to analyze the effect of community participation (willingness, ability and opportunity) on the prevention of Dengeu Hemorrhagic Fever (DHF) in Tanjung Penyembal Kelurahan with 80 respondents. The analysis showed that the willingness variable (p = 0.001), ability (p = 0.007) and chance (p = 0.005) influenced the prevention of DHF.
It is recommended to the Department of Health to be able to involve the community since the beginning of the implementation of the DHF prevention program, and to form a special team in the community to provide information and regular counseling to other communities, in order to increase the willingness, knowledge and ability of the community on how to handle DHF. It is expected that the Department of Health should establish a Training Program for Community Independence in the Prevention of Dengue Fever, wherein later this Village can be used as a Pilot Village for Community Involvement in Respecting Dengue in the region and also improve supervision and sweep larvae, as well as provide sanctions to the community where DHF mosquito larvae are present. The village / kelurahan apparatus should be able to work together with other communities to carry out environmental cleanliness (DHF PSN) to control dengue mosquito larvae.
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Syafutra, Wendy, Almurdi Almurdi, and Nur Afrainin Syah. "Hubungan Jumlah Leukosit dengan Trombosit pada Infeksi Dengue Primer dan Dengue Sekunder." Jurnal Ilmu Kesehatan Indonesia 2, no. 3 (August 26, 2022): 127–34. http://dx.doi.org/10.25077/jikesi.v2i3.326.
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Latar Belakang: Demam Berdarah Dengue (DBD) masih merupakan salah satu masalah kesehatan masyarakat yang utama di Indonesia. Leukopenia dan trombositopenia merupakan dua temuan laboratorium yang sering ditemukan pada perjalanan penyakit DBD.
Objektif: Penelitian ini bertujuan untuk mengetahui hubungan antara jumlah leukosit dengan trombosit pada infeksi dengue primer dan sekunder.
Metode: Penelitian ini merupakan analitik dengan pendekatan cross sectional. Sampel penelitian adalah pasien yang didiagnosis DBD di RSUP Dr.M.Djamil Padang dan RST Solok yang terdiri dari 2 kelompok data yaitu infeksi dengue primer dengan 24 sampel dan infeksi dengue sekunder 30 sampel. Waktu penelitian periode Januari - Juli 2020.
Hasil: Penelitian didapatkan infeksi dengue primer dengan rata-rata trombosit adalah 68.250 /mm3 dan rata-rata leukosit 3.922,5/mm3, infeksi dengue sekunder dengan rata-rata trombosit adalah 54.000 /mm3 dan rata-rata leukosit 4.272 /mm3. Terdapat korelasi tidak bermakna antara jumlah leukosit dengan trombosit pada infeksi dengue primer maupun sekunder dan koefisien regresi jumlah leukosit sebesar 0,484 pada infeksi dengue primer dan 0,010 pada infeksi dengue sekunder.
Kesimpulan: Tidak terdapat hubungan antara jumlah leukosit dengan trombosit pada infeksi dengue primer dan dengue sekunder.
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Chong, Zhuo Lin, Hui Jen Soe, Amni Adilah Ismail, Tooba Mahboob, Samudi Chandramathi, and Shamala Devi Sekaran. "Evaluation of the Diagnostic Accuracy of a New Biosensors-Based Rapid Diagnostic Test for the Point-Of-Care Diagnosis of Previous and Recent Dengue Infections in Malaysia." Biosensors 11, no. 5 (April 22, 2021): 129. http://dx.doi.org/10.3390/bios11050129.
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Dengue is a major threat to public health globally. While point-of-care diagnosis of acute/recent dengue is available to reduce its mortality, a lack of rapid and accurate testing for the detection of previous dengue remains a hurdle in expanding dengue seroepidemiological surveys to inform its prevention, especially vaccination, to reduce dengue morbidity. This study evaluated ViroTrack Dengue Serostate, a biosensors-based semi-quantitative anti-dengue IgG (immunoglobulin G) immuno-magnetic agglutination assay for the diagnosis of previous and recent dengue in a single test. Blood samples were obtained from 484 healthy participants recruited randomly from two communities in Petaling district, Selangor, Malaysia. The reference tests were Panbio Dengue IgG indirect and capture enzyme-linked immunosorbent assays, in-house hemagglutination inhibition assay, and focus reduction neutralization test. Dengue Serostate had a sensitivity and specificity of 91.1% (95%CI 87.8–93.8) and 91.1% (95%CI 83.8–95.8) for the diagnosis of previous dengue, and 90.2% (95%CI 76.9–97.3) and 93.2% (95%CI 90.5–95.4) for the diagnosis of recent dengue, respectively. Its positive predictive value of 97.5% (95%CI 95.3–98.8) would prevent most dengue-naïve individuals from being vaccinated. ViroTrack Dengue Serostate’s good point-of-care diagnostic accuracy can ease the conduct of dengue serosurveys to inform dengue vaccination strategy and facilitate pre-vaccination screening to ensure safety.
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Kurniati, Annelin, Ahmad Fandi, Mardhatillah Sariyanti, Ety Febrianti, and Debie Rizqoh. "Perbandingan Tingkat Keparahan Infeksi Sekunder Virus Dengue pada Keempat Serotipe di Indonesia: Systematic Review." Jurnal Kesehatan Andalas 10, no. 1 (June 19, 2021): 49. http://dx.doi.org/10.25077/jka.v10i1.1615.
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Secondary infection with the dengue virus causes mild to severe manifestations. The distribution of dengue virus serotypes varies in various areas and can change over time. There are four dengue serotypes, namely DENV-1, DENV-2, DENV-3 and DENV-4. Objectives: To knew the distribution of virus serotypes in an area and determined the pathogenesis of the disease, which can cause severe manifestations in patients with secondary infections. Methods: The data taken is the severity of secondary infections and dengue serotypes. The literature search was performed on PMC and Cochrane. Search criteria were performed using keywords (secondary infection * OR secondary dengue infection *) AND (Dengue Virus * OR Dengue Infection * OR Dengue * OR DENV) AND (Serotype * OR Serogroup) AND (severe dengue * OR severity * OR severity of illness indexs * OR dengue fever * OR dengue haemorrhage fever * OR dengue shock syndrome * OR DF * OR DHF * OR DSS *) AND (Indonesia *). Results: Literature study search found 387 literature with five studies conducted the analysis. From the results of the analysis, it was found that secondary infections were more common in patients with recurrent dengue infection with serotype 2 (DENV-2), serotype 3 (DENV-3) and serotype 4 (DENV-4). Conclusion: Secondary infection of dengue virus serotype 2 (DENV-2) and serotype 3 (DENV-3) can cause severe dengue infection.Keywords: Dengue Virus, Indonesia, Secondary Infection, Serotype, Severity
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Abhishek, Kumar S., Oves Siddiqui, and Anita Chakravarti. "Increasing number of secondary dengue cases: a concern." International Journal of Research in Medical Sciences 7, no. 5 (April 26, 2019): 1558. http://dx.doi.org/10.18203/2320-6012.ijrms20191635.
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ackground: Dengue fever is caused by mosquito borne arbovirus of family Flaviviridae, Aedes agypti as the principle vector. In the recent past Delhi has witnessed several outbreaks affecting thousands of individuals and many of them get re-infected during subsequent years forming a bulk of secondary dengue cases putting them at risk of developing severe dengue.Methods: A total of 150 serum samples from suspected dengue cases were tested for dengue fever by NS-1 antigen and IgM antibody enzyme-linked immunosorbent assay (ELISA) followed by categorization into primary and secondary dengue using IgG avidity ELISA.Results: Out of total 150 clinically suspected dengue cases, 56 were positive either by Dengue NS-1 antigen or dengue IgM antibody or both. On the basis of dengue IgG avidity ELISA among 56 diagnosed dengue cases, 30 (53.57%) were found to be of secondary dengue.Conclusions: There is increasing trend of dengue cases in Delhi since past one decade. Being hyper-endemic area for dengue, more than 25% population have been reported to have past infection of dengue. Due to increased prevalence and simultaneous circulation of more than one serotypes, number of secondary dengue cases is also increasing. Since majority of severe dengue cases are associated with secondary dengue, early diagnosis and treatment can significantly reduce the fatal outcome. Thus, avidity testing for IgG antibody becomes an important tool.
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Thi-Hien Cao and Thi-Bich-Thuy Luong. "Spatial analysis in epidemiological studies of dengue: A systematic review and meta-analysis." World Journal of Biology Pharmacy and Health Sciences 16, no. 3 (December 30, 2023): 187. http://dx.doi.org/10.30574/wjbphs.2023.16.3.0519.
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Background: Dengue is a serious tropical disease caused by the mosquito-borne dengue virus (DENV). Over the last 50 years, the incidence of dengue fever (DF) and dengue fever and dengue hemorrhagic fever (DHF) worldwide has increased by 50-fold and 2.5 billion people currently live in dengue-endemic regions. This study reports a systematic review and meta-analysis of different types of applications offered by spatial analysis in epidemiological studies of dengue. Materials and methods: A comprehensive literature search of Web of Science, SCOPUS, Google Scholar, and PubMed were conducted up to December 2023. A total of three sub-sections, namely spatial analysis of points, spatial analysis of area data, and software programs used for spatial analysis of dengue cases, will be presented in this review. Results: It was found that spatial analysis can effectively support the study of dengue fever and dengue hemorrhagic fever such as to investigate spatial patterns, hotspot, spatial clustering, the spread, transmission of dengue fever and dengue hemorrhagic fever and it’s affecting factors. Conclusion: applications of spatial analysis can provide important information and contribute to development of effective measurements to control and prevent the dengue fever and dengue hemorrhagic fever transmission. Finding in this study provide an insight into how to use different techniques in the study of dengue fever and dengue hemorrhagic fever.
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Matti, Mahantesh, Mahesh B. Maralihalli, and Shilpa Dinesh. "Comparison of morbidity and mortality between serologically positive and serologically negative dengue cases." International Journal of Contemporary Pediatrics 4, no. 5 (August 23, 2017): 1866. http://dx.doi.org/10.18203/2349-3291.ijcp20173801.
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Background: Dengue is most common arboviral disease caused by 4 types of dengue viruses. In most of the hospitals laboratory diagnosis is made by dengue serology using Rapid Immunochromatographic Test for NS1Ag, IgM and IgG antibodies. We found more morbidity and mortality in suspected dengue cases whose serology was negative for dengue.Methods: Children with clinical features suggestive for case definition for dengue, who belonged to group C of World Health organisation (WHO) guidelines for dengue fever (severe dengue), were included. They were categorised into dengue positive and dengue negative groups. The clinical features and complications of the disease between the two groups were compared.Results: 98 cases (77.8%) were serologically positive for dengue and 28 (22.2%) were negative. 39% of the patients with dengue negative serology developed hypotensive shock in comparison to 18% of dengue positive cases, mortality in serology negative cases (21%) was significantly higher than positive cases (8%).Conclusions: We could not find the reasons for more morbidity and mortality in seronegative dengue group, we stress up on improving the sensitivity and specificity of rapid diagnostic tests. More caution need to be taken for serology negative dengue cases. Epidemiological studies directed to find circulation of other viruses which causes dengue like symptoms should be made.
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Salvatory Kalabamu, Florence, and Shaaban Maliki. "Use of Haematological Changes as a Predictor of Dengue Infection among Suspected Cases at Kairuki Hospital in Dar Es Salaam, Tanzania: A Retrospective Cross Sectional Study." East African Health Research Journal 5, no. 1 (June 15, 2021): 91–98. http://dx.doi.org/10.24248/eahrj.v5i1.655.
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Background: Dengue is a viral disease transmitted by female Aedes mosquitoes which are commonly found in tropical and subtropical areas. There is a dramatic increase in annual incidence rate of dengue attributed to urbanisation, poor environmental management as well as increased people mobility. Outbreak of dengue have been reported in Tanzania in recent years with Dar es salaam being the most affected region. Dengue is associated with haematological derangements and itindicates the severity of the disease. These changes have not been well elucidated in Tanzanian patients. The aim of this study was to determine these derangements among dengue patients admitted at Kairuki hospital in Dar es salaam, and compare these changes with non- dengue febrile patients. Methods: A retrospective cross sectional study was conducted among patients who were suspected to have dengue; tested for dengue IgM and their Complete Blood Count were tested during the index illness. This information was obtained from Kairuki hospital laboratory database. Haematological parameters were compared between dengue and non-dengue patients using SPSS Version 20.0. Binary logistic regression analysis was used to determine haematological predictors of dengue positive results. Results: A total of 255 patients were enrolled, whereby 188(73.7%) were dengue positive and 67 (26.3%) were negative. Dengue patients had relatively low mean total white blood cell counts compared to non-dengue patients (Student’s test= -2.7; p value=.007). Furthermore, Mean lymphocyte count was significantly low in dengue patients compared to non-dengue patients (Student’s (t) test=-5.1; p<.001). Other haematological parameters were not significantly different. Lymphopenia was a significant predictor for dengue positive results (Adjusted Odd Ration =5.26 (95% CI=2.28-12.2; P value <.001). Conclusion: Patients with dengue had significantly low total white blood cell and lymphocyte count compared to non-dengue febrile patients. Lymphopenia is a significant haematological predictor for dengue positive results. Case defining signs and symptoms combined with these haematological changes may be used by clinicians as a guide to order confirmatory test for suspected dengue cases.
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Vaughn, David W., Ananda Nisalak, Siripen Kalayanarooj, Tom Solomon, Nguyen Minh Dung, Andrea Cuzzubbo, and Peter L. Devine. "Evaluation of a Rapid Immunochromatographic Test for Diagnosis of Dengue Virus Infection." Journal of Clinical Microbiology 36, no. 1 (1998): 234–38. http://dx.doi.org/10.1128/jcm.36.1.234-238.1998.
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A rapid (<7-min) immunochromatographic test for immunoglobulin M (IgM) and IgG antibodies to dengue viruses was evaluated by using hospital admission and discharge sera from 124 patients. The reference laboratory diagnosis was based on the results of virus isolation, hemagglutination-inhibition assay (HAI), and enzyme immunoassay (EIA). By the standard assays, patients experienced primary dengue virus infection (n = 30), secondary dengue virus infection (n = 48), Japanese encephalitis (JE) virus infection (n = 20), or no flavivirus infection (n = 26). The rapid test demonstrated 100% sensitivity in the diagnosis of dengue virus infection and was able to distinguish between primary and secondary dengue virus infections through the separate determinations of IgM and IgG. For all patients with primary dengue virus infection a positive test for IgM to dengue virus and a negative test for IgG to dengue virus were obtained, whereas for 46 of 48 patients (96%) with secondary dengue virus infection, a positive test for IgG to dengue virus with or without a positive test for IgM to dengue virus was obtained. The remaining two patients with secondary dengue virus infection had positive IgM test results and negative IgG test results. Furthermore, the rapid test was positive for patients confirmed to be infected with different dengue virus serotypes (12 infected with dengue virus serotype 1, 4 infected with dengue virus serotype 2, 3 infected with dengue virus serotype 3, and 2 infected with dengue virus serotype 4). The specificity of the test for nonflavivirus infections was 88% (3 of 26 positive), while for JE virus infections the specificity of the test was only 50% (10 of 20). However, most patients with secondary dengue virus infection were positive for both IgM and IgG antibodies to dengue virus, while no patients with JE virus infection had this profile, so cross-reactivity was only a concern for a small proportion of patients with secondary dengue infections. The rapid test demonstrated a good correlation with the reference EIA and HAI and should be useful for the rapid diagnosis of dengue virus infections.
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Said, Muhammad Faridzuan Faiz, Hasmah Abdullah, and Noraini Abdul Ghafar. "Dengue prevention practices among community in dengue hotspot area." International Journal Of Community Medicine And Public Health 5, no. 11 (October 25, 2018): 4664. http://dx.doi.org/10.18203/2394-6040.ijcmph20184553.
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Background: Dengue is one of the most important mosquito-borne diseases which can cause a major problem to human health. Poor practices in dengue prevention especially in the area where dengue is prevalent is among the factors contributing towards dengue spike. This study was commenced to assess the level of attitude and practice toward dengue prevention among the community residing in a dengue prone area, beside identifying the environmental characteristics surrounding the housing compound.Methods: A cross-sectional study was conducted among 132 respondents living in a dengue hot spot area. A set of questionnaire form consisted of four parts; socio-demographic information, environmental characteristics around the house, and attitudes and practices toward dengue prevention were distributed to respondents.Results: More than half of the respondents possessed good level of attitude, and more than half scored moderately for practice (57.6% and 56.1% respectively). Data on the environmental characteristics showed that majority of the respondents’ houses have no potential breeding sites for Aedes mosquito. Findings also indicate that there was no significant association between dengue prevention practices and socio-demographic factors such as age, gender, educational level and occupational status.Conclusions: Level of practice of dengue prevention is still considerably low and could be improved through educational campaign. Proper knowledge and information regarding dengue practices should be emphasized among the community especially in high risk area to raise up the awareness and cultivate better practices for dengue prevention.
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Huang, Kao-Jean, Shu-Yi J. Li, Shiour-Ching Chen, Hsiao-Sheng Liu, Yee-Shin Lin, Trai-Ming Yeh, Ching-Chuan Liu, and Huan-Yao Lei. "Manifestation of thrombocytopenia in dengue-2-virus-infected mice." Journal of General Virology 81, no. 9 (September 1, 2000): 2177–82. http://dx.doi.org/10.1099/0022-1317-81-9-2177.
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Dengue virus infection causes dengue fever, dengue haemorrhagic fever and dengue shock syndrome. No animal model is available that mimics these clinical manifestations. In this study, the establishment is reported of a murine model for dengue virus infection that resembles the thrombocytopenia manifestation. Dengue-2 virus (dengue virus type 2) can infect murine cells either in vitro (primary cell culture) or in vivo. Viraemia detected by RT–PCR was found transiently at 2 days after intravenous injection of dengue-2 virus. Transient thrombocytopenia developed at 10–13 days after primary or secondary infection. Anti-platelet antibody was generated after dengue-2 virus infection. There was strain variation in dengue-2 virus infection; the A/J strain was more sensitive than BALB/c or B6 mice. This dengue-2-virus-infected mouse system accompanied by thrombocytopenia and anti-platelet antibody will be a valuable model to study the pathogenicity of dengue virus infection.
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Fayyaz, Ayesha, Zahra Fayyaz, and Samina Fatima. "DENGUE FEVER;." Professional Medical Journal 24, no. 11 (November 3, 2017): 1605–9. http://dx.doi.org/10.29309/tpmj/2017.24.11.661.
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Introduction: Dengue can indicate a diverse clinical spectrum. The intensity ofhepatic involvement in patients, with dengue infection varies from soft injury to severe injury bymeans of jaundice and liver cell failure. Even if liver is not a most important objective limb, liverinvolvement is a renowned aspect. Objectives: The objective of this study was to assess liverinvolvement in dengue patients upto 12 years of age. Study Design: The study was Prospectiveobservational. Place and Duration of Study: Study was conducted in children ward, PaediatricDepartment, Holy Family Hospital Rawalpindi from August 2014 to October 2015. Methods:Upto 12 years of age, all suspected dengue children patients were screened and solitaryserologically established cases by dengue IgM capture ELISA were incorporated in the studyafter taking written permission from the parents of the patients. Patients were categorizedaccording to GCP dengue guidelines into dengue fever (DF), dengue hemorrhagic fever (DHF)and dengue shock syndrome (DSS). Results: Among 146 children, 78 were in the group of DF,35 were in the group of DHF and 33 were in the group of DSS. Most children (70 %) were above5 years. Fever was the leading illness followed by body aches, hepatomegly, rashes, edema,headache, petechiae, hepatic tenderness, pain in abdomen, vomiting, mucosal bleed andjaundice. Children with DSS have more liver involvement. Hepatomegaly and thickening of gallbladder was maximum in children with DSS and can be an indication of severe illness. Serumbilirubin, serum albumin, liver enzymes like ALT, AST and ALP were considerably elevated inchildren with DSS as compare to other two groups. 32 patients out of 33 with DSS had liverinvolvement. Conclusion: Dengue fever has become a main health issues at the moment inPakistan. Hepatic association in dengue in children has high fatality rate and spectrum variesfrom jaundice to rise of liver enzymes.
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Akther, Tahmina, Biswajit Paul, Saif Ullah Munshi, and Shahina Tabassum. "Diagnosis of Dengue Virus Infection in Oral Fluid using Immunochromatographic Tests." Bangladesh Journal of Medical Microbiology 11, no. 1 (January 26, 2017): 6–9. http://dx.doi.org/10.3329/bjmm.v11i1.51944.
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Dengue viral infections are diagnosed by detecting dengue NS1 antigen and dengue specific IgM/IgG antibody by traditional serological tests using patient's blood. Recently saliva is being used employed for diagnosis of different infectious diseases including dengue. In the present study, dengue NS1 antigen and anti-dengue IgM/IgG antibody were detected using rapid immunochromatographic (ICT) kits for diagnosis of dengue and compared with the results of serum ICT results performed on corresponding sera collected from the same individuals. A total of 215 suspected dengue patients were tested and dengue infection was found in 176 (81.9%) sera and 161 (74.9 %) oral fluid samples. Among the 30 dengue NS1 antigen positive sera, 28 were also positive for NS1 in oral fluid indicating high sensitivity (93.3%), specificity (100%), diagnostic accuracy (99.1%), PPV (100%) and NPV (98.9 %) of testing dengue NS1 antigen in oral fluid. Similarly oral fluid assay for anti-dengue IgM showed sensitivity, specificity, diagnostic accuracy, PPV and NPV of 87.3%, 100.0%, 95.8%, 100.0% and 94.1% respectively. Test for anti-dengue IgM/IgG in oral fluid showed sensitivity, specificity, diagnostic accuracy, PPV and NPV of 89.7%, 100.0%, 98.1%, 100.0% and 97.7% respectively. All these parameters for detection of anti-dengue IgG by ICT showed 100%in oral fluid. Thus, results from this study indicates that detection of dengue NS1 antigen or anti-dengue IgM/IgG in oral fluid is an alternative tool for dengue diagnosis. It may benefits dengue diagnosis especially in infants and children since it is easy to collect and require no additional sample processing. It also has the potential to use for epidemiological survey.
Bangladesh J Med Microbiol 2017; 11 (1): 6-9
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Suwanbamrung, Charuai, Cua Ngoc Le, Supreecha Kaewsawat, Nirachon Chutipattana, Patthanasak Khammaneechan, Supaporn Thongchan, Orratai Nontapet, et al. "Developing Risk Assessment Criteria and Predicting High- and Low-Dengue Risk Villages for Strengthening Dengue Prevention Activities: Community Participatory Action Research, Thailand." Journal of Primary Care & Community Health 12 (January 2021): 215013272110132. http://dx.doi.org/10.1177/21501327211013298.
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Background: Risk assessment criteria for predicting dengue outbreak must be appropriated at village levels. We aimed to develop risk dengue village prediction criteria, predict village dengue risk, and strengthen dengue prevention based on community participation. Methods: This participatory research conducted in Southern Thailand included the following 5 phases: (i) preparing communities in 3 districts; (ii) developing risk dengue village prediction criteria; (iii) applying computer program; (iv) predicting village dengue risk with 75 public health providers in 39 PCUs; and (v) utilizing findings to strengthen dengue prevention activities in 220 villages. Data collecting for prediction used secondary data from primary care units in the past 5 year and current year. Descriptive statistics used calculating criteria and comparing with standard level to adjust score of risk. Results: Risk dengue village assessment criteria had 2 aspects: dengue severity (3 factors) and dengue outbreak opportunity (3 factors). Total scores were 33 points and cut-off of 17 points for high and low dengue risks villages. All criteria were applied using computer program ( http://surat.denguelim.com ). Risk prediction involved stakeholder participation in 220 villages, and used for strengthening dengue prevention activities. The concept of integrated vector management included larval indices surveillance system, garbage management, larval indices level lower than the standard, community capacity activities for dengue prevention, and school-based dengue prevention. The risk prediction criteria and process mobilized villages for dengue prevention activities to decrease morbidity rate. Conclusion: Dengue risk assessment criteria were appropriated within the village, with its smallest unit, the household, included. The data can be utilized at village levels for evaluating dengue outbreak risks.
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Raviprakash, Kanakatte, Danher Wang, Dan Ewing, David H. Holman, Karla Block, Jan Woraratanadharm, Lan Chen, Curtis Hayes, John Y. Dong, and Kevin Porter. "A Tetravalent Dengue Vaccine Based on a Complex Adenovirus Vector Provides Significant Protection in Rhesus Monkeys against All Four Serotypes of Dengue Virus." Journal of Virology 82, no. 14 (May 14, 2008): 6927–34. http://dx.doi.org/10.1128/jvi.02724-07.
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ABSTRACT Nearly a third of the human population is at risk of infection with the four serotypes of dengue viruses, and it is estimated that more than 100 million infections occur each year. A licensed vaccine for dengue viruses has become a global health priority. A major challenge to developing a dengue vaccine is the necessity to produce fairly uniform protective immune responses to all four dengue virus serotypes. We have developed two bivalent dengue virus vaccines, using a complex adenovirus vector, by incorporating the genes expressing premembrane (prM) and envelope (E) proteins of dengue virus types 1 and 2 (dengue-1 and -2, respectively) (CAdVax-Den12) or dengue-3 and -4 (CAdVax-Den34). Rhesus macaques were vaccinated by intramuscular inoculation of a tetravalent dengue vaccine formulated by combining the two bivalent vaccine constructs. Vaccinated animals produced high-titer antibodies that neutralized all four serotypes of dengue viruses in vitro. The ability of the vaccine to induce rapid, as well as sustained, protective immune responses was examined with two separate live-virus challenges administered at 4 and 24 weeks after the final vaccination. For both of these virus challenge studies, significant protection from viremia was demonstrated for all four dengue virus serotypes in vaccinated animals. Viremia from dengue-1 and dengue-3 challenges was completely blocked, whereas viremia from dengue-2 and dengue-4 was significantly reduced, as well as delayed, compared to that of control-vaccinated animals. These results demonstrate that the tetravalent dengue vaccine formulation provides significant protection in rhesus macaques against challenge with all four dengue virus serotypes.
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Haqqi, Aleena, Aqsa Shafique, Abdur Rehman, and Hira Muzammal. "Dengue Dilemma, Understanding and Confronting Dengue in Pakistan." TSF Journal of Biology 1, no. 1 (June 19, 2023): 1–04. http://dx.doi.org/10.69547/tsfjb.v1i1.16.
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Dengue Virus, a mosquito-borne illness has emerged as a public health threat. In the post post-monsoon season from mid-September to the start of December, the atmospheric conditions are ideal for the dengue virus spread, leading to an upsurge in dengue infections. According to an estimate, roughly 5469 cases in Punjab alone have been reported and a total of 5088 cases from all above Pakistan to date have been reported. The dengue virus epidemic in Pakistan has been a constant healthcare concern for the past years. So, there is a need to effectively manage the spread of dengue virus.
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Wijayabandara, Maheshi, Devasmitha Wijesundara, Champika Gamakaranage, Panduka Karunanayake, Shyam Fernando, and Saroj Jayasinghe. "Dengue fever complicated with acute ST elevation myocardial infarction - a therapeutic conundrum: our experience from two cases." Asian Journal of Medical Sciences 12, no. 1 (January 1, 2021): 118–23. http://dx.doi.org/10.3126/ajms.v12i2.30410.
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Dengue fever has a wide range of clinical manifestations from asymptomatic disease to complicated dengue haemorrhagic fever and dengue shock syndrome. Bleeding manifestations in dengue is well known but thrombotic events complicating dengue is uncommon. ST elevation myocardial infarction during dengue is rare and poses important management dilemma. At present, there is no consensus on how to manage this situation. We present two patients with dengue fever developing ST elevation myocardial infarction and our experience in the management. We suggest case-based management of acute coronary syndrome in dengue, guided by the degree of thrombocytopaenia and bleeding risk. Further studies are needed to include this into existing dengue management guidelines.
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Khosla, Saniya, Rahul Chauhan, Ayush Aggarwal, and Nupur B. Patel. "Dengue encephalitis – An unusual case series." Journal of Family Medicine and Primary Care 13, no. 8 (July 26, 2024): 3420–23. http://dx.doi.org/10.4103/jfmpc.jfmpc_413_24.
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ABSTRACT Dengue infection can take on many different forms, ranging from no symptoms to a mild fever, all the way to a severe condition known as dengue shock syndrome. Although the typical symptoms of dengue are well known, the virus can also cause rare neurological complications. Dengue encephalitis is a severe form of neuroinvasive dengue that can be fatal as the virus directly affects the central nervous system. This case series provides a comprehensive overview of dengue, its clinical spectrum, and the potential for severe neurological complications such as dengue encephalitis. It highlights the importance of considering dengue as a possible diagnosis in patients with encephalitis, particularly during a dengue epidemic.
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Shastri, Jayanthi, Manita Williamson, Nilima Vaidya, Sachee Agrawal, and Om Shrivastav. "Nine year trends of dengue virus infection in Mumbai, Western India." Journal of Laboratory Physicians 9, no. 04 (October 2017): 296–302. http://dx.doi.org/10.4103/jlp.jlp_169_16.
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Abstract INTRODUCTION: Dengue virus (DENV) causes a wide range of diseases in humans, from acute febrile illness Dengue fever (DF) to life-threatening Dengue hemorrhagic fever (DHF) or Dengue shock syndrome (DSS). Factors believed to be responsible for spread of Dengue virus infection include explosive population growth, unplanned urban overpopulation with inadequate public health systems, poor standing water and vector control, climate changes and increased international recreational, business, military travel to endemic areas. All of these factors must be addressed to control the spread of Dengue and other mosquito-borne infections. The detection of Dengue virus RNA by reverse transcriptase PCR (RT-PCR) in human serum or plasma samples is highly indicative of acute Dengue fever. Moreover, the method is able to identify the Dengue virus serotype by demonstrating defined sequence homologies in the viral genomic RNA. METHODS AND RESULTS: During the nine year period of this study analysis, 6767 strongly suspected cases were tested by RT-PCR. 1685 (24.9%) were Dengue PCR positive and confirmed as Dengue cases. Observations on the seasonality were based on the nine year's data as the intensity of sampling was at its maximum during monsoon season. Dengue typing was done on 100 positive samples after storage of Dengue RNA at – 80°C. Dengue serotypes were detected in 69 samples of which Dengue 2 was most predominant. 576 samples were processed for NS1 antigen and PCR simultaneously. 19/576 were positive (3.3 %) for NS1 as well as by PCR. 23/576 samples were negative for NS1 antigen, but were positive by RT-PCR. The remaining 534 samples which were negative for NS1 antigen were also negative by Dengue RT-PCR. CONCLUSION: In this study we sought to standardize rapid, sensitive, and specific fluorogenic probe-based RT-PCR assay to screen and serotype a representative range of Dengue viruses that are found in and around Mumbai. Qualitative Dengue virus TaqMan assays could have tremendous utility for the epidemiological investigation of Dengue illness and especially for the study of the viremic response with candidate live-attenuated dengue virus vaccines.
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Santhi, Heppy, Irnawati Marsaulina, and Nurmaini. "Revenue, Knowledge, Attitudes, and Implementation Regarding the Dengue Fever Prevention Program in Medan, Indonesia." Britain International of Exact Sciences (BIoEx) Journal 2, no. 1 (January 3, 2020): 77–83. http://dx.doi.org/10.33258/bioex.v2i1.102.
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The best program to control the spread of dengue infection is a dengue prevention program. Indonesia has a dengue prevention program known as 3M Plus. Medan City is one of the endemic areas of dengue fever in Indonesia. This study aims to evaluate the income, knowledge, attitude and implementation of the dengue prevention program in Medan. Information on sociodemography, knowledge, attitudes, and implementation of dengue prevention was collected using a semistructured questionnaire that had been tested previously. This cross-sectional survey was conducted with face-to-face interviews with 100 randomly selected heads of households. Bivariate analysis using chi-square test. The results showed that overall participants had low family income, poor dengue knowledge, moderate attitude and moderate prevention implementation. There was a significant positive relationship between family income and implementation of dengue prevention (p = 0.001), knowledge and implementation of dengue prevention (p = 0.012), and attitudes and implementation of dengue prevention (p <0.001). In conclusion, dengue prevention programs require increased knowledge, attitudes and implementation of dengue prevention. Households with an income below the city minimum wage must be the main target of the dengue prevention campaign. Knowledge-based campaigns and arousing positive attitudes will increase the application of dengue prevention.
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Ghafar, Noraini Abdul, and Shamsul Azhar Shah. "Validity and reliability of an instrument assessing the associated factors for preventive behavior towards dengue." International Journal Of Community Medicine And Public Health 4, no. 2 (January 25, 2017): 340. http://dx.doi.org/10.18203/2394-6040.ijcmph20170252.
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Background: Dengue is one of the most important vector-borne diseases in Malaysia. Government efforts alone are not sufficient in preventing the disease if people continue to allow the widespread mosquito breeding in their housing compound. Individual or community behavior is an important factor in the prevention of dengue. However, there is no standard instrument to measure the associated factors of dengue preventive behavior. This study commenced to validate and assess the reliability of a newly developed instrument for the constructs measuring factors associated with dengue preventive behavior.Methods: A total of 327 respondents involved in this pilot study, which is a preliminary study to a larger scale study. Exploratory factor analysis (EFA) was employed to explore underlying constructs of the latent variables.Results: From the EFA, 10 factors (knowledge regarding dengue, behavior toward dengue prevention, fear and awareness toward dengue, motivation to adopt preventive behavior, medical practices for dengue fever, cooperation in dengue prevention, perceived susceptibility of dengue, perceived severity of dengue, perceived benefit from practicing dengue preventive behavior, and perceived barrier toward dengue preventive behavior) emerged contributing 63.1 percent of the total variance with the reliability of 0.791.Conclusions: The questionnaire is valid and reliable to measure the associated factors of preventive behavior toward dengue.