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Aryati, Aryati. "ANALISIS FILOGENETIK DENGUE DI INDONESIA." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 18, no. 2 (March 17, 2018): 111. http://dx.doi.org/10.24293/ijcpml.v18i2.1009.
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Molecular epidemiology is needed to solve the problem for endemic Dengue Hemorrhagic Fever in Indonesia.This research has been carried out consisting of 525 Dengue Hemorrhagic Fever sera, according to the WHO criteria.These sera were collected from 19 cities in Indonesia comprising the islands of Sumatera, Batam, Kalimantan, Sulawesi, Papua, Java,Bali and Lombok from 2003 until 2005. The immune response profile was as follows 57.14% (300/525) secondary infection, 12.57%(66/525) primary infection, 4.20% (22/525) equivocal and 26.09% (137/525) negative. From 192 PCR samples, 100 (52%) serawere positive, consisting of 65% DEN-2, 15% DEN-3, 12% DEN-4 and 8% DEN-1. Homology analysis showed nucleotide differences incapsid region DEN-2 serotypes, while DEN-3 serotypes were relatively consistent. Phylogenetic analysis using envelope (E) gene revealedthat the Cosmopolitan genotype from Gorontalo in 2005, is currently circulating locally, with the potential to cause a severe hemorrhagicdisease. Members of this genotype were closely related to viruses from Malaysia, Singapore, Thailand, Philippines and Australia. Theisolate from Jakarta, 2003 showed DEN-3 with I genotype. This genotype was similar to the isolate from Indonesia 1978, 1985, andalso from Thailand 1992, Philippines 1997, and Fiji 1992. These results showed Cosmopolitan genotype from DEN-2 was similar toSoutheast Asia countries. It was also revealed that genotype-I from DEN-3 showed no change over the years since 1978.
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Amalia, Dika, and Fadhilah Amirah. "Seorang Anak Laki-Laki Usia 9 tahun Dengan Demam Dengue." GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh 1, no. 3 (October 10, 2022): 21. http://dx.doi.org/10.29103/jkkmm.v1i3.8775.
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Demam Dengue (DD) adalah penyakit akut yang disebabkan oleh virus dengue, yang ditularkan oleh nyamuk betina Ae. aegypti juga Ae. albopictus. Virus dengue terdapat 4 serotipe, yaitu DEN-1, DEN-2, DEN-3, serta DEN-4. Demam dengue ditemukan di iklim tropis dan sub-tropis di seluruh dunia. Anak Indonesia adalah kelompok rentan mengalami infeksi dengue dan terjadi pada kasus usia 0–14 tahun. Tatalaksana tepat pada anak penting dalam menurunkan morbiditas dan mortalitas infeksi dengue di Indonesia.
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Fatmawati, Fajar, and Sulistyawati Sulistyawati. "CLIMATE CHANGE AND DENGUE IN INDONESIA: A SYSTEMATIC REVIEW." Epidemiology and Society Health Review (ESHR) 1, no. 1 (September 10, 2019): 29. http://dx.doi.org/10.26555/eshr.v1i1.938.
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Background: Climate change is a global issue because of its impact on environmental and human health. No exception for Indonesia, an archipelago state with a tropical climate. Climate change potentially influences the mosquitos borne disease, including dengue fever, which poses a vulnerability to the Indonesian populations. This article aims to review the association and the impact of climate change to dengue fever, particularly in Indonesia and to inform the policymaker on directing the adaptation option.Methods: Of thirteen peer review articles were included in this review sourced from google scholar database.Results: Climate change affects dengue incidence in Indonesia due to climate variability.Conclusions: It is essential to Strengthen the surveillance system and provide an early warning system (EWS) based on climate information.Keywords: Climate change, dengue, Indonesia
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Karyanti, Mulya Rahma, and Sri Rezeki Hadinegoro. "Perubahan Epidemiologi Demam Berdarah Dengue Di Indonesia." Sari Pediatri 10, no. 6 (November 29, 2016): 424. http://dx.doi.org/10.14238/sp10.6.2009.424-32.
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Dengue berdarah dengue yang ditularkan melalui vektor nyamuk Aedes aegypty masih merupakan masalah kesehatan penting di dunia. Di Indonesia, demam berdarah dengue mulai dikenal pertama kali pada tahun 1968 di DKI Jakarta dan Surabaya, dan terus menyebar ke seluruh tiga puluh tiga propinsi di Indonesia. Pola epidemiologi infeksi dengue mengalami perubahan dari tahun ke tahun, jumlah kasus memuncak setiap siklus 10 tahunan. Dari tahun 1968-2008 angka kesakitan demam berdarah dengue terus meningkat. Pada tahun 2008 didapatkanangka kesakitan 58,85/ 100.000 penduduk. Angka kematian menurun dengan stabil dari 41% pada tahun 1968 menjadi kurang dari 2% sejak tahun 2000, dan pada tahun 2008 angka kematian menurun menjadi 0,86%.Semua serotipe virus dengue ditemukan di Indonesia, namun serotipe virus den-3 masih dominan menyebabkan kasus dengue yang berat dan fatal. Surveilans epidemiologi, dukungan edukasi masyarakat dan program pengendalian vektor diperlukan untuk mencegah transmisi. Pengembangan vaksin dengue merupakan salah satu upaya mencegah penyakit dengue.
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Sidarta, Erick, Sari Mariyati Dewi, and Arlends Chris. "ANALISA EVOLUSI VIRUS DENGUE YANG ENDEMIK DI INDONESIA." Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan 3, no. 1 (October 2, 2019): 91. http://dx.doi.org/10.24912/jmstkik.v3i1.2856.
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Indonesia merupakan daerah dengan hiperendemisitas tinggi untuk infeksi virus dengue dan tempat bersirkulasinya keempat varian genotype virus dengue. Saat ini salah satu cara untuk pencegahan infeksi virus dengue adalah dengan vaksin dengue yang baru tersedia tahun 2016. Vaksin dengue ini menstimulasi terbentuknya antibodi yang akan mengenali membran dan selubung dari keempat genotipe virus dengue. Efektivitas dari vaksin ini tergantung dari kesesuaian antara antibodi yang terbentuk dengan varian yang beredar di Indonesia. Mengingat virus dengue merupakan virus RNA yang umumnya memiliki laju mutasi yang tinggi, mutasi yang terjadi dapat mengakibatkan terbentuknya escape mutant yang mampu menghindari antibodi yang terbentuk oleh vaksin. Penelitian ini bertujuan untuk mengetahui evolusi dan laju mutasi dari virus dengue yang beredar di Indonesia. Sebanyak 116 data genom lengkap dari virus dengue yang telah dilaporkan di Indonesia digunakan dalam penelitian ini. Genotipe virus dengue dianalisa dengan menggunakan software MEGA-X. Evolusi dan laju mutasi dari gen penyandi selubung (E) dan membran (M) virus dengue dianalisa dengan menggunakan software BEAST versi 1.8.3. Hasil dari penelitian ini menunjukkan gen E dan M virus dengue telah berevolusi semenjak pertama kali dilaporkan pada tahun 1975 dan memiliki laju mutasi yang tinggi. Gen E mencapai 9.26 x 10-4 subsitusi/basa/tahun (95% HPD 7.81 X 10 10-4 – 1.07 X 10-3) maupun gen M yang mencapai 8.5 x 10-4 subsitusi/basa/tahun (95% HPD 6.03 X 10 10-4 – 1.09 X 10-3). Tingginya laju mutasi ini membutuhkan perhatian bagi pengembang vaksin untuk pengawasan dan evaluasi yang berkesinambungan. Indonesia is an area with high hyperendemicity for dengue virus infection and the circulation of the four variants of dengue virus genotype. Currently, one way to prevent dengue virus infection is with a new dengue vaccine available in 2016. This dengue vaccine stimulates the formation of antibodies that will recognize the membrane and envelope of the four dengue virus genotypes. The effectiveness of this vaccine depends on the suitability of the antibodies formed with variants circulating in Indonesia. Since dengue virus is an RNA virus that generally has a high mutation rate, the mutations that occur can result in the formation of escape mutants that are able to avoid the antibodies formed by the vaccine. This study aims to determine the evolution and mutation rate of dengue viruses circulating in Indonesia. A total of 116 complete genome data from dengue viruses that have been reported in Indonesia were used in this study. Dengue virus genotypes were analyzed using MEGA-X software. The evolution and mutation rate of the envelope (E) and membrane (M) gene of the dengue virus were analyzed using BEAST software version 1.8.3. The results of this study indicate that the E and M genes of the dengue virus have evolved since they were first reported in 1975 and have a high mutation rate. Gen E reaches 9.26 x 10-4 substitution / base / year (95% HPD 7.81 X 10 10-4 - 1.07 X 10-3) and M gene reaches 8.5 x 10-4 substitution / base / year (95% HPD 6.03 X 10 10-4 - 1.09 X 10-3). The high rate of this mutation requires attention for vaccine developers for ongoing monitoring and evaluation.
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Ahmad, Khabir. "Dengue death toll rises in Indonesia." Lancet 363, no. 9413 (March 2004): 956. http://dx.doi.org/10.1016/s0140-6736(04)15829-7.
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Arya, Subhash C., and Anjali Varma. "Rising dengue death toll in Indonesia." Lancet 363, no. 9421 (May 2004): 1651. http://dx.doi.org/10.1016/s0140-6736(04)16221-1.
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Nadjib, Mardiati, Ery Setiawan, Septiara Putri, Joshua Nealon, Sophie Beucher, Sri Rezeki Hadinegoro, Vetty Yulianty Permanasari, et al. "Economic burden of dengue in Indonesia." PLOS Neglected Tropical Diseases 13, no. 1 (January 10, 2019): e0007038. http://dx.doi.org/10.1371/journal.pntd.0007038.
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Götz, Thomas, Nicole Altmeier, Wolfgang Bock, Robert Rockenfeller, Sutimin, and Karunia Putra Wijaya. "Modeling dengue data from Semarang, Indonesia." Ecological Complexity 30 (June 2017): 57–62. http://dx.doi.org/10.1016/j.ecocom.2016.12.010.
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Massey, Firdaus Kabiru, and Rika Yulia. "REVIEW ARTICLE: DEVELOPEMENT AND USING DENGUE VACCINE FOR DENGUE INFECTION VIRUS." Medical and Health Science Journal 3, no. 2 (August 30, 2019): 8. http://dx.doi.org/10.33086/mhsj.v3i2.1194.
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Abstract : Tropical and subtropical countries are regions with high incidence of dengue infection. Dengue virus infection is estimated to cause 300 million new infections in one year and approximately 1 million severe cases with 2 + 5% deaths. The case of dengue in Indonesia has continued to increase since 1968 until 1980 where all provinces in Indonesia have been affected by the dengue virus. Dengue virus is a virus carried by the Aedes aegypti mosquito in its salivary gland. The virus which is a family group of Flaviviruses has four homologous serotypes, namely DENV-1, DENV-2, DENV-3, and DENV-4, which can cause dengue infection in individuals. Currently there is a shift in the target population from children to adults. This is a problem that needs to be resolved by the government and the community itself. Solution to overcome this, the government needs early prevention efforts to reduce the severity of dengue infection by developing and researching dengue vaccines. Currently a vaccine has been found that can be used as prophylaxis for dengue virus, namely Dengvaxia. This vaccine has been recommended by the World Health Organization (WHO) as prophylaxis for dengue infection, but Dengvaxia is only used in areas that are very endemic to dengue fever. The Indonesian Food and Drug Supervisory Agency (BPOM RI) has also approved the use of Dengvaxia as an indication of prevention of dengue infection since August 31, 2016. This vaccine has been approved globally only given to individuals aged between 9-16 years.
Keyword : dengue virus, dengvaxia vaccine, Aedes aegypti, endemic
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Solikhah, Suwarno, and Puput Septian Permatasari. "Demam berdarah dengue di Kota Bima Nusa Tenggara Barat Indonesia." MEDIA ILMU KESEHATAN 10, no. 2 (January 29, 2022): 146–53. http://dx.doi.org/10.30989/mik.v10i2.564.
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Background: Dengue hemorrahagic fever (DHF) remains public health problem in some areas in Indonesia. As a tropical country, supported by heavy rainfall subsequently caused extraordinary events dengue every year. The low level of knowledge, attitudes and behavior of the Indonesian regarding how to prevent and manage dengue has become a trigger for outbreaks in several parts of Indonesia. Objective: This study aimed to describe the incidence of dengue fever in the Bima city, East Nusa Tenggara Indonesia in 2020. Methods: This study used mix-method approach. Quantitative data were obtained from secondary data on dengue cases from January to July 2020 and in-depth interviews with the managers of the disease surveillance program at the Bima City Health Office. Results: The results of this study showed that the increase in the number of dengue cases from 2019 was 144 cases. While in 2020 the increase in dengue cases occurred in the Jatibaru Puskesmas work area in March 2020 as many as 246 cases. The majority of DHF sufferers are female and aged 5-9 years. Conclusion: Cross-program cooperation in health promotion efforts in the City of Bima needs to be increased to motivate the community to always carry out Clean and Healthy Living Behaviors (as well-known PHBS).
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Corwin, Andrew Lee, Ria Purwita Larasati, Michael J. Bangs, Suharyono Wuryadi, Sumarjati Arjoso, Nono Sukri, Erlin Listyaningsih, et al. "Epidemic dengue transmission in southern Sumatra, Indonesia." Transactions of the Royal Society of Tropical Medicine and Hygiene 95, no. 3 (May 2001): 257–65. http://dx.doi.org/10.1016/s0035-9203(01)90229-9.
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Syafutra, Wendy, Almurdi Almurdi, and Nur Afrainin Syah. "Hubungan Jumlah Leukosit dengan Trombosit pada Infeksi Dengue Primer dan Dengue Sekunder." Jurnal Ilmu Kesehatan Indonesia 2, no. 3 (August 26, 2022): 127–34. http://dx.doi.org/10.25077/jikesi.v2i3.326.
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Latar Belakang: Demam Berdarah Dengue (DBD) masih merupakan salah satu masalah kesehatan masyarakat yang utama di Indonesia. Leukopenia dan trombositopenia merupakan dua temuan laboratorium yang sering ditemukan pada perjalanan penyakit DBD.
Objektif: Penelitian ini bertujuan untuk mengetahui hubungan antara jumlah leukosit dengan trombosit pada infeksi dengue primer dan sekunder.
Metode: Penelitian ini merupakan analitik dengan pendekatan cross sectional. Sampel penelitian adalah pasien yang didiagnosis DBD di RSUP Dr.M.Djamil Padang dan RST Solok yang terdiri dari 2 kelompok data yaitu infeksi dengue primer dengan 24 sampel dan infeksi dengue sekunder 30 sampel. Waktu penelitian periode Januari - Juli 2020.
Hasil: Penelitian didapatkan infeksi dengue primer dengan rata-rata trombosit adalah 68.250 /mm3 dan rata-rata leukosit 3.922,5/mm3, infeksi dengue sekunder dengan rata-rata trombosit adalah 54.000 /mm3 dan rata-rata leukosit 4.272 /mm3. Terdapat korelasi tidak bermakna antara jumlah leukosit dengan trombosit pada infeksi dengue primer maupun sekunder dan koefisien regresi jumlah leukosit sebesar 0,484 pada infeksi dengue primer dan 0,010 pada infeksi dengue sekunder.
Kesimpulan: Tidak terdapat hubungan antara jumlah leukosit dengan trombosit pada infeksi dengue primer dan dengue sekunder.
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Hasan, Rizqy Lazuardy, and Erick Sidarta. "Analisis cross reactivity protein precursor membrane (prM) virus dengue endemik Indonesia dengan pendekatan imunoinformatik." Tarumanagara Medical Journal 4, no. 1 (April 30, 2022): 179–87. http://dx.doi.org/10.24912/tmj.v4i2.18280.
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Infeksi demam berdarah dianggap sebagai salah satu masalah kesehatan utama di Indonesia dan disebabkan oleh virus dengue. Kemampuan reaksi silang pada virus dengue dapat memperparah jika terjadi infeksi lainnya. Protein precursor membrane (prM) pada virus dengue merupakan bagian yang rentan akan terjadinya antibody dependant enhancement dan evolusi gen prM berubah setiap tahunnya. Studi ini bertujuan untuk menganalisa reaksi silang gen prM dari virus dengue yang endemis di Indonesia. Sebanyak 96 data sampel dari National Center for Biotechnology Information digunakan pada studi ini. Prediksi antigenisitas dengan metode B-cell epitope prediction lalu di lanjutkan proses analisis reaksi silang menggunakan Basic Local Aligntment Search Tool (BLAST) dengan perbagian 20 protein prM pada setiap genotype virus yang memiliki antigenisitas yang spesifitasnya 0,8. Hasil dari studi ini didapatkan 4 prediksi antigenisitas dan beberapa hasil reaksi silang terhadap protein lain seperti anti-SARS-CoV-2 immunoglobulin heavy chain, human immunodeficiency virus type I enhancer-binding protein 2, insulin receptor substrate like protein partial, cerebellar-degeneration-related antigen. Pada studi ini ditemukan adanya perubahan prediksi antigenisitas dari gen prM virus dengue yang muncul setiap tahun dan adanya reaksi silang dengan protein lain.
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Mahdalena, Vivin, and Rahayu Hasti Komaria. "PENGENDALIAN DEMAM BERDARAH DENGUE DENGAN OVITRAP DAN MOSQUITO TRAP DI BEBERAPA DAERAH DI INDONESIA." SPIRAKEL 13, no. 1 (December 7, 2021): 42–50. http://dx.doi.org/10.22435/spirakel.v13i1.5257.
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The Dengue Fever (DF)/Dengue Hemorrhagic Fever (DHF) is still a major public health problem in Indonesia. Indonesia of DHF cases in 2019 increased compared to the previous year, which was 138.127 cases with an Incidence Rate (IR) of 51.53 per 100.000 population. The vectors of dengue virus are Aedes aegypti, Aedes albopictus, Aedes polynesiensis, and Aedes scutellaris mosquitoes. Prevention of dengue transmission relies mainly through vector control. The use of traps such as ovitrap and mosquito trap has the potential to be applied and integrated with other methods. Ovitrap and mosquito trap usage information is expected to be applied in the community and can assist in the dengue vector control program. The data in this article were secondary data from several research results that had been published and were field experiment. Ovitrap and mosquito trap are able to trap Aedes and non-Aedes mosquitoes. The effectiveness of the trap can be increased through the use of attractants from plant-based ingredients in the form of straw soaking water, mixture of brown sugar and yeast, mixture of granulated sugar and yeast, and chili extract. Ovitrap and mosquito trap with attractants from plant-based ingredients were quite effective in reducing the density of Aedes mosquitoes, besides that it safer for humans and non-target animals.
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Ningtyas, Ni Wayan Rahayu. "PENYULUHAN DEMAM BERDARAH PADA SISWA/SISWI DI SDN 2 SIDOREJO PANGKALAN BUN." Jurnal Borneo Cendekia 4, no. 2 (June 8, 2021): 204–11. http://dx.doi.org/10.54411/jbc.v4i2.244.
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Demam Berdarah dengue adalah salah satu bentuk klinis dari penyakit akibat infeksi dengan virus dengue pada manusia sedangkan manifestasi klinis dan infeksi virus dengue dapat berupa demam dengue dan demam berdarah dengue. Dengue adalah penyakit daerah tropis dapat ditularkan oleh nyamuk Aedes Aegypti, nyamuk ini adalah nyamuk rumah yang menggigit pada siang hari. Penyakit demam berdarah dengue merupakan masalah kesehatan di Indonesia hal ini tampak dari kenyataan seluruh wilayah di Indonesia mempunyai resiko untuk terjangkit penyakit demam berdarah dengue. Sebab baik virus penyebab maupun nyamuk penularanya sudah tersebar luas di perumahan-perumahan penduduk.Kata Kunci : Penyuluhan, Demam Berdarah
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Widyantoro, Wahyu, Nurjazuli Nurjazuli, and Yusniar Hanani. "Pengendalian Demam Berdarah Dengue (DBD) Berbasis Masyarakat di Indonesia: Systematic Review." Jurnal Ilmu Kesehatan Masyarakat 10, no. 03 (September 1, 2021): 200–207. http://dx.doi.org/10.33221/jikm.v10i03.1008.
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Demam berdarah dengue (DBD) masih menjadi maslah kesehatan di Indonesia. Berbagai program telah dilaksanakan oleh pemerintah untuk menanggulangi DBD. Pelibatan masyarakat dalam pengendalian menjadi penting dalam upaya pengendalian DBD. Kajian sistematis ini bertujuan untuk mengetahui pelibatan komunitas dalam intervensi pengendalain DBD di Indonesia. Metode dalam penelitian ini adalah systematic review dengan menggunakan metode PRISMA. Kami melakukan pencarian literatur empat data base elektronik : Google Scholar, PubMed, Web of Science, Scopus dengan data open access dari tahun 2015 hingga 2020. Artikel dipilih berdasarkan kriteria inklusi community dengue control, engangment dengue control, sosial capital dengue control dan didapatkan 5 artikel yang sesuai untuk dikaji. Penelitian ini menggunakan metode studi pustaka dengan menggunakan data penelitian dengan topik yang sama sebagai data sekunder. Pelibatan komunitas menjadi bagian keberhasilan dalam pengendalian DBD di Indonesia.hasil intervensi meliputi pengetahuan, sikap dan praktik di komunitas; partisipasi masyarakat; modal social dan pemberdayaan masyrakat mampu menurunkan parameter terhadap kejadian maupun kasus DBD. Keberhasilan pelibatan komunitas dalam pengendalian DBD di Indonesia perlu adanya program keberlanjutan dan kesinambungan.
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Sucipto, Teguh Hari, Tomohiro Kotaki, Kris Cahyo Mulyatno, Siti Churrotin, Amaliah Labiqah, Soegeng Soegijanto, and Masanori Kameoka. "Phylogenetic Analysis of Dengue Virus in Bangkalan, Madura Island, East Java Province, Indonesia." Journal of Tropical Medicine 2018 (2018): 1–6. http://dx.doi.org/10.1155/2018/8127093.
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Dengue virus (DENV) infection is a major health issue in tropical and subtropical areas. Indonesia is one of the biggest dengue endemic countries in the world. In the present study, the phylogenetic analysis of DENV in Bangkalan, Madura Island, Indonesia, was performed in order to obtain a clearer understanding of its dynamics in this country. A total of 359 blood samples from dengue-suspected patients were collected between 2012 and 2014. Serotyping was conducted using a multiplex Reverse Transcriptase-Polymerase Chain Reaction and a phylogenetic analysis of E gene sequences was performed using the Bayesian Markov chain Monte Carlo (MCMC) method. 17 out of 359 blood samples (4.7%) were positive for the isolation of DENV. Serotyping and the phylogenetic analysis revealed the predominance of DENV-1 genotype I (9/17, 52.9%), followed by DENV-2 Cosmopolitan type(7/17, 41.2%)and DENV-3 genotype I(1/17, 5.9%). DENV-4 was not isolated. The Madura Island isolates showed high nucleotide similarity to other Indonesian isolates, indicating frequent virus circulation in Indonesia. The results of the present study highlight the importance of continuous viral surveillance in dengue endemic areas in order to obtain a clearer understanding of the dynamics of DENV in Indonesia.
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Nusa, Roy, Heni Prasetyowati, Febrina Meutiawati, Benediktus Yohan, Hidayat Trimarsanto, Tri Yuli Setianingsih, and R. Tedjo Sasmono. "Molecular surveillance of Dengue in Sukabumi, West Java province, Indonesia." Journal of Infection in Developing Countries 8, no. 06 (June 11, 2014): 733–41. http://dx.doi.org/10.3855/jidc.3959.
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Introduction: Dengue is endemic and affects people in all Indonesian provinces. Increasing dengue cases have been observed every year in Sukabumi in West Java province. Despite the endemicity, limited data is available on the genetic of dengue viruses (DENV) circulating in the country. To understand the dynamics of dengue disease, we performed molecular and serological surveillance of dengue in Sukabumi. Methodology: A total of 113 patients were recruited for this study. Serological data were obtained using anti-dengue IgM and IgG tests plus dengue NS1 antigen detection. Dengue detection and serotyping were performed using real-time RT-PCR. Viruses were isolated and the envelope genes were sequenced. Phylogenetic and evolutionary analyses were performed to determine the genotype of the viruses and their evolutionary rates. Results: Real-time RT-PCR detected DENV in 25 (22%) of 113 samples. Serotyping revealed the predominance of DENV-2 (16 isolates, 64%), followed by DENV-1 (5 isolates, 20%), and DENV-4 (4 isolates, 16%). No DENV-3 was detected in the samples. Co-circulation of genotype I and IV of DENV-1 was observed. The DENV-2 isolates all belonged to the Cosmopolitan genotype, while DENV-4 isolates were grouped into genotype II. Overall, their evolutionary rates were similar to DENV from other countries. Conclusions: We revealed the distribution of DENV serotypes and genotypes in Sukabumi. Compared to data obtained from other cities in Indonesia, we observed the differing predominance of DENV serotypes but similar genotype distribution, where the infecting viruses were closely related with Indonesian endemic viruses isolated previously.
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Prihadi, Dana Nur, Tetty Yuniati, and Azhali Manggu S. "Monositosis dan Limfositosis Merupakan Faktor Risiko Demam Berdarah Dengue pada Anak." Majalah Kedokteran Bandung 41, no. 4 (2009): 201–6. http://dx.doi.org/10.15395/mkb.v41n4.254.
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Wirawan, Dewa Nyoman. "Pemantauan dan Pencegahan Penularan Virus Zika di Indonesia." Public Health and Preventive Medicine Archive 4, no. 1 (July 1, 2016): 1. http://dx.doi.org/10.15562/phpma.v4i1.48.
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Sama halnya dengan Virus Dengue dan Virus Chikungunya, Virus Zika juga ditularkan oleh nyamuk Aedes aegypti. Karena populasi nyamuk Aedes aegypti sangat tinggi di Bali serta wilayah lain di Indonesia, maka penularan Virus Zika di Bali/Indonesia bisa dipastikan juga akan terjadi sama halnya dengan negara lain seperti Vietnam, Thailand dan Singapura. Karena itu, melakukan pencegahan penularan dari luar negeri ke Bali/Indonesia dengan memantau suhu tubuh di bandara pada orang-orang yang datang dari luar negeri tidak cukup untuk mencegah penularan karena sebagian besar orang yang terinfeksi tidak menunjukkan gejala (tidak demam), tetapi bisa menularkan virus di Bali/Indonesia. Untuk mengetahui kemungkinan terjadinya penularan di Bali/Indonesia, maka satu-satunya cara yang bisa dilakukan adalah pemantauan atau surveilans. Surveilans bisa dilakukan secara paralel dengan surveilans Demam Berdarah Dengue yang telah dilaksanakan selama ini. Untuk menetapkan terjadinya infeksi Virus Zika, diperlukan pemeriksaan laboratorium. Upaya lainnya adalah meningkatkan awareness kepada masyarakat dan petugas kesehatan terhadap adanya kemungkinan penularan Virus Zika di Bali/Indonesia. Kepada petugas kesehatan perlu diberikan pemahaman bahwa bila dijumpai adanya infeksi Virus Zika maka diperlukan konseling yang memadai kepada pasien untuk tidak melakukan hubungan seks atau memakai kondom dengan istri/suaminya atau pasangan seksualnya selama 60 hari guna mencegah terjadinya penularan melalui seksual. Sama halnya dengan pencegahan penularan infeksi Virus Dengue, pemantauan jentik nyamuk Aedes aegypti dan pemberantasan sarang nyamuk (PSN) amat perlu ditingkatkan.
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Wicaksono, Andri Permana, and Demiawan Rachmatta Putro Mudiono. "Sistem Pakar Diagnosis Typoid Fever dan Dengue Fever Berbasis Web." Jurnal Kesehatan 7, no. 3 (January 28, 2020): 155–61. http://dx.doi.org/10.25047/j-kes.v7i3.126.
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Negara Indonesia salah satu negara tropis. Curah hujan yang tinggi dengan kepadatan penduduk di wilayah Indonesia menghasilkan berbagai banyak penyakit. Salah satu penyakit yang sering muncul adalah penyakit yang diakibatkan oleh infeksi dan parasit tropis. Penyakit yang tergolong dengan infeksi dan parasit yang sering di negara Indonesia yaitu Thypoid fever dan Dengue fever. Sistem pakar adalah inovasi terbaru dalam mendeteksi kondisi awal. Sistem pakar dapat diimplementasikan di sektor kesehatan, salah satunya adalah sistem diagnosis ahli yang berguna untuk mendiagnosis penyakit dengan gejala demam pada manusia dengan melihat karakteristik dan gejala yang dialami pasien. Penelitian ini bertujuan untuk mendiagnosis demam tifoid dan Dengue Fever yang disebabkan oleh gejala demam pada pasien. Metode penelitian ini adalah metode penelitian pengembangan dengan menggunakan metode sanders yang meliputi definisi masalah, analisis sistem, perancangan sistem, dan implementasi sistem. Hasil penelitian ini, menggunakan metode dempster shafer untuk menentukan penilaian terhadapat penyakit Typoid fever dan dengue Fever sehingga dari hasil tersebut mendapatkan nilai kekauratan dengan persentase penyakit typoid fever mencapai 93% dan dengue fever mencapai 94% dapat digunakan sebagai referensi untuk keakuratan diagnosis untuk mencegah penyakit Typoid Fever dan Dengue Fever.
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Saifullin, M. A., E. I. Kelly, M. V. Bazarova, V. F. Larichev, L. S. Karan, Yu A. Akinshina, and A. M. Butenko. "Dengue fever fatal case." Epidemiology and Infectious Diseases 20, no. 2 (April 15, 2015): 49–51. http://dx.doi.org/10.17816/eid40879.
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The article presents data about the clinic, postmortem studies and specific diagnosis of the first registered in the Russian Federation fatal case of dengue fever that is associated with the first and only trip to Indonesia. The patient had hemorrhagic form of dengue fever with shock syndrome.
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Ningtyas, Annisa Maulida, Ismil Khairi Lubis, and Guntur Budi Herwanto. "Monitoring Persebaran Penyakit Demam Berdarah Dengue dengan Memanfaatkan Data Berita Online." Jurnal Kesehatan Vokasional 4, no. 2 (May 31, 2019): 105. http://dx.doi.org/10.22146/jkesvo.44691.
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Latar Belakang: Implementasi surveilans penyakit di Indonesia masih menggunakan metode tradisional, yaitu dengan mengumpulkan data langsung di lapangan. Surveilans penyakit dengan menggunakan metode tradisional ini memiliki beberapa kekurangan, yaitu data real dilapangan sulit didapatkan secara real-time pada skala global dan laporan mengenai persebaran penyakit memerlukan waktu yang panjang.Tujuan: Tujuan dari penelitian in adalah untuk melakukan studi pendahuluan penggunaan berita online untuk surveilans penyakit,yang diharapkan dapat menyajikan informasi mengenai persebaran penyakit Demam Berdarah Dengue (DBD) di Indonesia secara real-time.Metode: Data yang digunakan adalah data berita yang berasal dari beberapa portal berita online, seperti kompas.com, tempo.com, krjogja.com dan sebagainya, yang diambil dalam rentang waktu tertentu. Ekstraksi fitur lokasi pada berita menggunakan metode dictionary pattern matching.Hasil: Hasil dari penelitian ini ditemukan persebaran penyakit berdasarkan fitur lokasi dalam berita di 9 Provinsi di Indonesia, yaitu Banten, DI Yogyakarta, Jambi, Jawa Barat, Jawa Tengah, Kalimantan Timur, Kalimantan Utara, Nusa Tenggara Timur dan Sumatera Utara. Hasil uji korelasi menunjukan bahwa terdapat korelasi antara kemunculan fitur lokasi dengan banyaknya kasus dilapangan. Kemudian dari hasil perbandingan dengan peringkat 5 besar provinsi dengan angka kejadian tertinggi, ditemukan bahwa 3 dari 9 provinsi memiliki kesesuaian dengan data dari Kementerian Kesehatan, yaitu Jawa Tengah, Sumatera Utara dan Jawa BaratKesimpulan: Surveilans dengan memanfaatkan berita online berkorelasi dengan data dari Kementerian Kesehatan dan dapat menyajikan informasi persebaran DBD secara real-time, namun penelitian ini masih memiliki kekurangan, yaitu jumlah berita yang tidak relevan masih cukup tinggi dan masih condong pada suatu daerah.
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Maharsi, Sri, Oktia Woro Kasmini Handayani, and Yuni Wijayanti. "Efectivity Evaluation among Dengue Control Programs in Semarang City, Indonesia." Unnes Journal of Public Health 9, no. 2 (July 31, 2020): 135–40. http://dx.doi.org/10.15294/ujph.v9i2.37512.
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Increased dengue cases occur throughout Southeast Asia. Semarang Health Office held programs to control dengue,which are Rainfall monitoring,Routine Mosquito Larvae Monitoring Program, One House One Larvae Observer Movement, And Students look For Mosquito Larvae Movement. To assess whether the programs reducing Dengue Hemorrhagic Fever caseswere effective. The method used were correlation analysis. Data obtained from every region in Semarang and reported to Semarang Health Office. Average Dengue Hemorrhagic Fever case was 79.5±13.69. Correlationtest results between dengue cases with rainfall was r=0.951;p=0.049, Larvae Absence Rate from Routine Mosquito Larvae Monitoring Program was r=0.648;p=0.352, with Larvae Absence Rate from One House One Larvae Observer Movement was r=0.804;p=0.196, with Larvae Absence Rate from Students Search For Mosquito Larvae Movement was r=0.961;p=0.039. Correlation between rainfall and Larvae Absence Rate from Students Search For Mosquito Larvae Movement with Dengue Hemorrhagic Fever case were significant and had positive strong correlation,correlation test results of Larvae Absence Rate from Routine Mosquito Larvae Program and One House One Larvae Observer Movement had strong correlation but were not significant.
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Harapan, Harapan, Alice Michie, Timo Ernst, Kritu Panta, Mudatsir Mudatsir, Benediktus Yohan, Sotianingsih Haryanto, Suzi McCarthy, R. Tedjo Sasmono, and Allison Imrie. "Co-Circulation of Chikungunya and Multiple DENV Serotypes and Genotypes, Western Indonesia 2015–2016." Viruses 14, no. 1 (January 6, 2022): 99. http://dx.doi.org/10.3390/v14010099.
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Dengue is a mosquito-borne disease of public health concern affecting tropical and subtropical countries, including Indonesia. Although studies on dengue epidemiology have been undertaken in Indonesia, data are lacking in many areas of the country. The aim of this study was to determine dengue virus (DENV) and chikungunya virus (CHIKV) molecular epidemiology in western regions of the Indonesian archipelago. A one-year prospective study was conducted in Aceh and Jambi in 2015 and 2016, respectively, where patients with dengue-like illness were enrolled. Of 205 patients recruited, 29 and 27 were confirmed with dengue in Aceh and Jambi, respectively, and three from Jambi were confirmed with chikungunya. DENV-1 was the predominant serotype identified in Aceh while DENV-2 was predominant in Jambi. All DENV-1 and DENV-2 from both regions were classified as Genotype I and Cosmopolitan genotype, respectively, and all DENV-3 viruses from Jambi were Genotype I. Some viruses, in particular DENV-1, displayed a distinct lineage distribution, where two DENV-1 lineages from Aceh were more closely related to viruses from China instead of Jambi highlighting the role of travel and flight patterns on DENV transmission in the region. DENV-2 from both Aceh and Jambi and DENV-3 from Jambi were all closely related to Indonesian local strains. All three CHIKV belonged to Asian genotype and clustered closely with Indonesian CHIKV strains including those previously circulating in Jambi in 2015, confirming continuous and sustainable transmission of CHIKV in the region. The study results emphasize the importance of continuous epidemiological surveillance of arboviruses in Indonesia and simultaneous testing for CHIKV among dengue-suspected patients.
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Sari, Rita Kartika, Imam Djamaluddin, Qathrunnada Djam’an, and Tjatur Sembodo. "Pemberdayaan Masyarakat dalam Upaya Pencegahan Demam Berdarah Dengue DBD di Puskesmas Karangdoro." Jurnal ABDIMAS-KU: Jurnal Pengabdian Masyarakat Kedokteran 1, no. 1 (January 11, 2022): 25. http://dx.doi.org/10.30659/abdimasku.1.1.25-33.
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Salah satu jenis penyakit menular yang menjadi endemik di Indonesia adalah demam berdarah dengue (DBD). Penyebaran DBD di Indonesia sangat dipengaruhi oleh mobilitas penduduk, kepadatan penduduk, dan kondisi lingkungan seperti keberadaan wadah/tempat buatan atau alami di tempat pembuangan sampah atau tempat sampah lainnya. Infeksi Dengue merupakan masalah kesehatan masyarakat. Masalah kesehatan tersebut belum berhasil mencapai “Indonesia Sehat” sebagaimana yang dikehendaki dalam Rencana Pembangunan Jangka Panjang Nasional salah satunya masih terdapat penyakit menular yang menjadi endemik di Indonesia adalah demam berdarah dengue (DBD). Di Indonesia insiden DBD masih tinggi dan penyebarannya semakin meluas, sehingga dibutuhkan pengendalian vector yang lebih intensif. Demam Berdarah Dengue (DBD) merupakan penyakit yang menimbulkan masalah bagi masyarakat. WHO melaporkan bahwa setiap tahunnya 50 juta penduduk dunia terinfeksi virus dengue dan 2,5% dari mereka meninggal dunia. Tujuan memberdayakan masyarakat dalam upaya pencegahan DBD di Puskesmas Karangdoro, Tempat pelaksanaan edukasi masyarakat di Puskesmas Karangdoro, Waktu pelaksanaan pelatihan tanggal 11 Mei 2021. Responden masyarakat, dan petugas puskesmas Karangdoro berjumlah 65 orang. Metode pelaksanaan kegiatan dengan metode berbasis kelompok yang dilakukan secara komprehensif, mulai dari koordinasi dengan pengambil kebijakan di Puskesmas Karangdoro, pendekatan dan koordinasi dengan masyarakat, edukasi pada masyarakat dan pendampingan, dan diskusi. Kegiatan tim pengabdian masyarakat dilakukan secara terukur dan proses monev untuk mengukur ketercapaian target dan luaran, melalui peran masyarakat dan puskesmas sehingga dapat meningkatkan derajad kesehatan pada masyarakat. Hasil pelaksanaan edukasi pada masyarakat mendapatkan pengetahuan dan wawasan tentang DBD sehingga masyarakat dapat diberdayakan untuk ikut serta dalam pencegahan DBD. Kata kunci: Demam berdarah dengue; endemi; pemberdayaan masyarakat; derajad kesehatan masyarakat
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Satoto, Tri Baskoro Tunggul, Nur Alvira Pascawati, Ajib Diptyanusa, Luthfan Lazuardi, Alvin Harjono Dwiputro, and Ariyanto Nugroho. "FLUKTUASI DEMAM BERDARAH DENGUE TERKAIT VARIABILITAS CUACA DI KLATEN, INDONESIA." Vektora : Jurnal Vektor dan Reservoir Penyakit 13, no. 1 (July 30, 2021): 45–60. http://dx.doi.org/10.22435/vk.v13i1.4333.
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Klaten Regency is one of the Dengue Hemorrhagic Fever (DHF) endemic areas in Central Java. Weather conditions can have an impact on vector dynamics, dengue virus development, and interactions between mosquitoes and humans. The purpose of this study was to determine the pattern of dengue transmission in twenty-six sub-districts in Klaten Regency based on wind speed, specific humidity, rainfall, and temperature. This study was conducted using a retrospective cohort design based on Giovanni-National Aeronautics and Space Administration (NASA) data during the last three years (2016-2018). The independent variables in this study were: wind speed (m/s), specific humidity (g/kg), rainfall (mm/month), and temperature (oC), while the dependent variable was the number of dengue cases in 26 sub-districts in 2014-2014. 2016. Data were analyzed based on monthly patterns and regional patterns using correlation and regression tests with =0.05. The results showed that a total of 1,434 dengue cases were reported during this time period. Weather data analysis revealed that DHF fluctuations were correlated with wind speed in four sub-districts, specific humidity in seven sub-districts, rainfall in three sub-districts, and temperature in three sub-districts. Specific humidity variation plays a role of 21.8% as the dominant factor that can explain the case of DHF in the Klaten Regency. The results of this study can be applied to mitigate the transmission of DHF by determining preventive actions according to place and time and increasing the early warning system to deal with the threat of DHF outbreaks.
Abstrak
Kabupaten Klaten adalah salah satu daerah endemis Demam Berdarah Dengue (DBD) di Jawa Tengah. Kondisi cuaca dapat berdampak pada dinamika vektor, perkembangan virus dengue, dan interaksi antara nyamuk dengan manusia. Tujuan dari penelitian ini adalah untuk mengetahui pola penularan DBD di dua puluh enam kecamatan yang berada di Kabupaten Klaten berdasarkan kecepatan angin, kelembaban spesifik, curah hujan dan suhu. Penelitian ini dilakukan menggunakan desain kohort retrospektif berdasarkan pada data Giovanni-National Aeronautics and Space Administration (NASA) selama 3 tahun terakhir (2016-2018). Variabel bebas dalam penelitian ini adalah: kecepatan angin (m/s), kelembaban spesifik (g/kg), curah hujan (mm/bulan) dan suhu (oC), sedangkan variabel terikat adalah jumlah kasus DBD di 26 kecamatan pada tahun 2014-2016. Data dianalisis berdasarkan pola bulanan dan pola wilayah dengan menggunakan uji korelasi dan regresi dengan α=0,05. Hasil penelitian menunjukkan bahwa total sebanyak 1.434 kasus dengue dilaporkan selama periode waktu tersebut. Analisis data cuaca mengungkapkan bahwa fluktuasi DBD berkorelasi dengan kecepatan angin di empat kecamatan, kelembaban spesifik di tujuh kecamatan, curah hujan di tiga kecamatan dan suhu di tiga kecamatan. Variasi kelembaban spesifik berperan sebesar 21,8% sebagai faktor dominan yang dapat menjelaskan kasus DBD di Kabupaten Klaten. Hasil studi ini dapat diaplikasikan untuk mitigasi penularan DBD dengan menentukan tidakan pencegahan menurut tempat dan waktu serta meningkatkan sistem kewaspadaan dini untuk menghadapi ancaman KLB DBD.
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Yohan, Benediktus, Rama Dhenni, Rahma F. Hayati, Frilasita Aisyah Yudhaputri, Dionisius Denis, Yanuarni WB Pamai, Anna Matiana Afida, et al. "Whole genome sequencing of Indonesian dengue virus isolates using next-generation sequencing." Indonesian Journal of Biotechnology 23, no. 2 (December 24, 2018): 74. http://dx.doi.org/10.22146/ijbiotech.38788.
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Indonesia is a tropical country and hyperendemic for dengue. The disease prevalently affected Indonesian and it caused high morbidity and substantial economic burden. This vector-borne viral disease is caused by infection of dengue viruses (DENVs), which are the member of Flaviviridae family. While most of dengue studies in Indonesia focused on the epidemiology, the clinical aspects, the vectors, and to certain extent the virology, there were still gaps in the DENVs genomic aspects. Considering their high mutation rate, the DENVs were known for their high genetic diversity and it might affect the characteristics of the viruses. Comprehensive DENV genomic data were thus important for many aspects of disease management, including virus surveillance, pathogenesis, diagnostics, antiviral drug design, and vaccine development. We established in this study a method for DENV whole genome sequencing using the advanced Next-Generation Sequencing (NGS) and Nextera XT DNA library preparation kit, coupled with simplified bioinformatic analysis methods. The Indonesian DENVs from four serotypes were isolated from patients’ sera, while library was prepared from enriched templates and sequenced using Illumina NGS. Our study highlighted the potential of a robust NGS method in producing whole genome sequence of DENVs, which would be important for future dengue studies.
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Fadilla, Z., UK Hadi, and S. Setiyaningsih. "Bioekologi vektor demam berdarah dengue (DBD) serta deteksi virus dengue pada Aedes aegypti (Linnaeus) dan Ae. albopictus (Skuse) (Diptera: Culicidae) di kelurahan endemik DBD Bantarjati, Kota Bogor." Jurnal Entomologi Indonesia 12, no. 1 (March 20, 2015): 31–38. http://dx.doi.org/10.5994/jei.12.1.31.
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Pimpi, La, Sapto Wahyu Indratno, Juni Wijayanti Puspita, and Edi Cahyono. "Stochastic and Deterministic Dynamic Model of Dengue Transmission Based on Dengue Incidence Data and Climate Factors in Bandung City." Communication in Biomathematical Sciences 5, no. 1 (August 2, 2022): 78–89. http://dx.doi.org/10.5614/cbms.2022.5.1.5.
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Indonesia, a country in the tropics, is an area of distribution and an endemic area of dengue. The death rate caused by dengue is relatively high In Indonesia. Therefore, the health authority must prioritize preventing and controlling dengue disease for a long-term policy. This study proposes a method based on dynamic climate variables in estimating the proportion of infected human and infected mosquito. We focus on the dengue case in Bandung city, one of the big cities in Indonesia, which is classified as endemic dengue. We applied the Poisson regression method involving dynamic climate variables to estimate the average number of infected human population. We then use these estimation results as the basis for approximating the proportion of infected human and mosquito populations using a deterministic and stochastic model approach. Effective reproduction number is also obtained here. The simulation results show that the stochastic model looks better in capturing dengue incidence data than the deterministic model. Therefore, dengue transmission can be reduced by controlling the abundance of mosquito populations, considering climate conditions and the historical number of infected human.
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Rejeki, Dwi Sarwani Sri, Nunung Nurhayati, and Budi Aji. "A spatiotemporal analysis of dengue hemorrhagic fever in Banyumas, Indonesia." International Journal of Public Health Science (IJPHS) 10, no. 2 (June 1, 2021): 231. http://dx.doi.org/10.11591/ijphs.v10i2.20713.
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Dengue hemorrhagic fever (DHF) is a public health problem in the world and also in Indonesia. One of the districts in Central Java that is still having problems with this disease is Banyumas, Indonesia. The incidence rate (IR) data in 2018 was 2.75 per 100,000 populations and the case fatality rate (CFR) was 3.64%. Spatiotemporal analysis was used to determine local variation, geographic determination of risk zones, and measurement of disease control interventions. Therefore, this study aimed to determine the distribution and grouping of dengue cases based on the spatiotemporal analysis. The design was observational with a cross-sectional spatial analysis. This study was conducted in Banyumas, Indonesia with the analysis unit for dengue fever patients in 2018 using as many as 57 cases. Furthermore, the data analysis used includes overlay, buffering, and clustering with SaTScan and ArcGis software. The results showed that there was a clustering of dengue cases in Banyumas, with one primary and three secondary clusters detected. The primary cluster occurred in March-April 2018, involving four sub-districts in urban areas. It was then concluded that the significantly identified clusters indicate a transmission of dengue fever in the Banyumas area with a radius of three kilometers.
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Stevani, Devi, Himatul Husna, Muthia Ardiyanti, Yuni Andira Sari, Desi Nurfita, Sugiarto Sugiarto, and Siti Nurkhoiriyah. "DENGUE RISK FACTOR IN BANGUNTAPAN III PHC, BANTUL, INDONESIA." Epidemiology and Society Health Review (ESHR) 2, no. 1 (May 5, 2020): 31. http://dx.doi.org/10.26555/eshr.v2i1.1873.
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Background: Dengue Haemorrhagic Fever (DHF) is an infectious disease caused by Aedes aegypti mosquito. DHF is widespread in some regions, with the number of patients continues to increase every year. This study aimed to determine the risk factors for DHF include 3M + program implementation, residential distance, hanging clothes habit, napping habit, repellent usage, and sunlight conditions.Method: Analytic study with case-control approach was used in this study. Samples consist of case and control. Of 16 cases and 32 controls were participated in this study who purposively selected. Data were collected using a questionnaire. Univariate and bivariate using chi-square tests were employed to analyze the result.Result: Three variables are associated with the incidence of dengue: napping habit (OR=11.667), residential distance (OR=1.696), and sunlight condition (OR=0.0289).Conclusions: napping habit, residential distance, and Sunlight Conditions are a risk factor of DHF.
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SUKRI, NONO C., ANDREW L. CORWIN, JOSEF R. RACHDYATMAKA, SUKMAN DIDI, KEVIN R. PORTER, STEVIE OSOK, H. JAMES BEECHAM, et al. "TRANSMISSION OF EPIDEMIC DENGUE HEMORRHAGIC FEVER IN EASTERNMOST INDONESIA." American Journal of Tropical Medicine and Hygiene 68, no. 5 (May 1, 2003): 529–35. http://dx.doi.org/10.4269/ajtmh.2003.68.529.
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O’Driscoll, Megan, Natsuko Imai, Neil M. Ferguson, Sri Rezeki Hadinegoro, Hindra Irawan Satari, Clarence C. Tam, and Ilaria Dorigatti. "Spatiotemporal variability in dengue transmission intensity in Jakarta, Indonesia." PLOS Neglected Tropical Diseases 14, no. 3 (March 6, 2020): e0008102. http://dx.doi.org/10.1371/journal.pntd.0008102.
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Nuryunarsih, Desy. "Sociodemographic Factors to Dengue Hemmorrhagic Fever Case in Indonesia." Kesmas: National Public Health Journal 10, no. 1 (August 1, 2015): 10. http://dx.doi.org/10.21109/kesmas.v10i1.813.
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Dengue hemorrhagic fever (DHF) is a leading cause of hospitalization and death among children. Indonesia is one of those countries categorized by World Health Organization (WHO) as hyperendemicity with four serotypes circulating in urban area. Sociodemographic factors are considered as factors affecting DHF in Indonesia. This study used secondary data downloaded from Province Health Database 2010 of Health Ministry Republic of Indonesia to determine correlation between three sociodemographic factors to DHF incidence. This study used quantitative descriptive correlational methods. Results showed the selected two sociodemographic factors had a linear impact on DHF incidence. Multiple regression multivariate analysis showed least correlation between DHF incidence and three selected sociodemographic factors. However, the univariate regression analysis showed that population density and poverty had significant correlation to DHF, respectively the population density r(4) = 0.843, p value < 0.05 and poverty r(4) = 0.897, p value < 0.05. Variable of age under 15 years old did not have any positive correlation to DHF. It is expected this study may have contribution to DHF prevention programs by helping public health practitioners develop more strategies with respect to the sociodemographic factors.Faktor-faktor Sosiodemografi terhadap Kasus Demam Berdarah diIndonesiaDemam berdarah dengue (DBD) adalah penyebab utama rawat inap dan kematian pada anak-anak. Indonesia adalah salah satu negara yang oleh WHO dikategorikan hyperendemicity dengan empat serotipe virus tersebar di daerah perkotaan. Faktor sosiodemografi dianggap sebagai faktor pendukung terjadinya DBD di Indonesia. Studi ini menggunakan data sekunder yang diunduh dari Basis Data Kesehatan Provinsi tahun 2010 Kementerian Kesehatan Republik Indonesia untuk menentukan korelasi antara ketiga faktor sosiodemografi dengan insiden DBD. Penelitian ini menggunakan metode kuantitatif deskripsi korelasi. Hasil penelitian menunjukkan bahwa dua faktor sosiodemografi terpilih memiliki korelasi linier dengan insiden DBD. Analisa regresi multivariat menunjukkan kecilnya korelasi antara insiden DBD dengan sekaligus tiga faktor sosiodemografi terpilih. Akan tetapi, hasil perhitungan analisa regresi univariat menunjukkan bahwa kepadatan penduduk dan kemiskinan memiliki korelasi yang signifikan terhadap DBD. Kepadatan penduduk r(4) = 0,843, nilai p < 0,05, sedangkan kemiskinan r(4)= 0,897, nilai p < 0,05. Variabel usia di bawah 15 tahun tidak memiliki korelasi positif terhadap insiden DBD. Diharapkan penelitian ini dapat memiliki kontribusi terhadap program pencegahan DBD dengan cara membantu praktisi kesehatan masyarakat mengembangkan strategi pencegahan DBD, terutama yang berhubungan dengan faktor sosiodemografi.
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Wardhani, Puspa, Aryati Aryati, Benediktus Yohan, Hidayat Trimarsanto, Tri Y. Setianingsih, Dwiyanti Puspitasari, Muhammad Vitanata Arfijanto, Bramantono Bramantono, Suharto Suharto, and R. Tedjo Sasmono. "Clinical and virological characteristics of dengue in Surabaya, Indonesia." PLOS ONE 12, no. 6 (June 2, 2017): e0178443. http://dx.doi.org/10.1371/journal.pone.0178443.
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Arcari, P., N. Tapper, S. Pfueller, and C. Windi. "THE IMPORTANCE OF CLIMATE FOR DENGUE/DHF IN INDONESIA." Epidemiology 16, no. 5 (September 2005): S37—S38. http://dx.doi.org/10.1097/00001648-200509000-00083.
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Pratamawati, Diana Andriyani. "Peran Juru Pantau Jentik dalam Sistem Kewaspadaan Dini Demam Berdarah Dengue di Indonesia." Kesmas: National Public Health Journal 6, no. 6 (June 1, 2012): 243. http://dx.doi.org/10.21109/kesmas.v6i6.76.
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Program pencegahan dan pemberantasan demam berdarah dengue (DBD) telah berlangsung sekitar 43 tahun dan berhasil menurunkan angka kema- tian dari 41,3% pada tahun 1968 menjadi 0,87% pada tahun 2010, tetapi belum berhasil menurunkan angka kesakitan. Bahkan, Indonesia men- duduki urutan tertinggi kasus DBD di Association of Southeast Asian Nations (ASEAN) pada tahun 2010. Salah satu faktor belum efektifnya pencegahan DBD di Indonesia adalah masih lemahnya sistem kewas- padaan dini. Peran juru pantau jentik (jumantik) sangat penting dalam sistem kewaspadaan dini mewabahnya DBD karena berfungsi untuk memantau keberadaan dan menghambat perkembangan awal dari vektor penular DBD. Seiring masih tingginya angka kasus DBD di Indonesia, muncul pertanyaan bagaimana peran jumantik dalam sistem kewaspadaan dini DBD selama ini di Indonesia. Artikel ini mencoba menelaah masalah tersebut berdasarkan tinjauan pustaka. Secara umum, peran jumantik dinilai cukup berhasil dalam pencegahan DBD, namun terdapat beberapa hal yang perlu menjadi bahan evaluasi.Kata kunci: Jumantik, demam berdarah dengue, sistem kewaspadaan diniAbstractPrograms of prevention and eradication of dengue hemorrhagic fever (DHF) has been around 43 years and managed to reduce mortality from 41,3% in 1968 to 0,87% in 2010, but has not managed to reduce morbidity. Indonesia even ranked the highest of dengue cases in Association of Southeast Asian Nations (ASEAN) by the year 2010. One factorthat made has not been effective dengue prevention in Indonesia is the early warning system is still weak. Jumantik role is very important in the early warning system outbreaks of dengue hemorrhagic fever because it serves to monitor the presence andinhibit the early development of vector-borne dengue fever. During the high number of dengue cases in Indonesia, question rouses how jumantik role in the dengue hemorrhagic fever early warning system so far in Indonesia. This article takes a closer look based on a literature review. In general, the role of jumantik considered quite successful in preventing dengue hemorrhagic fever early warning system but nevertheless there are things that need to be evaluated.Key words: Jumantik, dengue hemorrhagic fever, early warning system
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Xu, Zhiwei, Hilary Bambrick, Laith Yakob, Gregor Devine, Francesca D. Frentiu, Rina Marina, Pandji Wibawa Dhewantara, Roy Nusa, R. Tedjo Sasmono, and Wenbiao Hu. "Using dengue epidemics and local weather in Bali, Indonesia to predict imported dengue in Australia." Environmental Research 175 (August 2019): 213–20. http://dx.doi.org/10.1016/j.envres.2019.05.021.
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Sulistyawati, Sulistyawati, Tri Wahyuni Sukesi, and Surahma Asti Mulasari. "Spatiotemporal mapping of dengue cases in Sleman district, Indonesia year 2014-2017." International Journal Of Community Medicine And Public Health 6, no. 3 (February 22, 2019): 971. http://dx.doi.org/10.18203/2394-6040.ijcmph20190579.
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Background: Dengue is a significant public health problem in the mostly tropical country such as Indonesia. Even though many efforts have been established in Indonesia, in fact, dengue remains drawing attention from the health sector. Geographic Information System (GIS) is a powerful tool to support dengue surveillance on understanding the dengue pattern with the goal to give input for the decision maker. Accordingly, there is a need to providing the presence and the dynamic of dengue case particularly in Sleman district to establish evidence on building dengue control strategy.Methods: A descriptive study using GIS was performed to provide a spatial-temporal mapping of dengue case. Secondary data which sourced from Sleman district health office was collected for period 2014-2017. This data was grounded into subdistrict level. Quantum GIS and Microsoft Excel were used to analyse the data.Results: During 2014-2017 dengue spreads over the Sleman district. In 2016, found the increased of subdistrict with high dengue case. The high dengue case found in sub-district with an urban characteristic.Conclusions: Mapping of dengue using GIS is helpful to understanding the disease presence and dynamic disease over time.
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Soegijanto, Soegeng, Kris Cahyo Mulyanto, Siti Churotin, Tomohiro Kotaki, Masa Nori Kamioka, Eiji Konichi, Atsusi Yamanaka, and Dyah Wikanesthi. "SERO-EPIDEMIOLOGY OF DENGUE VIRUS INFECTION IN CITIES OF INDONESIA." Indonesian Journal of Tropical and Infectious Disease 4, no. 4 (October 1, 2013): 26. http://dx.doi.org/10.20473/ijtid.v4i4.229.
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Background: Dengue Virus Infektion is major public health problem in Indonesia. Aedesaegypti is widespread in both urban and rural areas, where multiple virus Serotype are circulating. On 2013 outbreak of dengue virus infection occur in East Java. Therefore study seroepidemiology in Bangkalan and Lombok had been done. Aim: to find a mutated strain of Dengue Virus in 4 cities of Indonesia. Method: On 2011 and 2012 seroepidemiology study had been done in Dr. Soetomo Surabaya and Soerya Sidoarjo Hospital; and on 2013 study had been done in Surabaya, Bangkalan and Lombok Hospital . Diagnosis of Dengue Virus Infection was based on Criteri WHO - 2009. Virus isolation in Surabaya, Sidoarjo, Bangkalan and Lombok had been done. Result: a total of 349 isolate were obtained from dengue patients sera collected in Surabaya and Sidoarjo, 2011–2012 showed that Den V1 (182), Den V2 (20) Den V4 (1) were found in Surabaya on 2011 and Den V 1 (79) , Den V 2 (7) were found in Surabaya on 2012; Den V1 (40), Den V 2 (3) were found in Sidoarjo on 2011 and Den V 1 (17) were found in Sidoarjo on 2012; Virus isolation in Surabaya on 2013, January: 237 serum sample were collected, found Den V 1 (8), Den V 3 (2) and Den V 4 (5). And PCR stereotyping of isolated viruses in Madura found Den V 1 (1) and Den V 4 (23). In Lombok found Den V 4 (4).It is possible to shift predominant strain in Surabaya , Genotype or Serotype shift might increase the number of dengue patients. Conclusion: there were shift predominant strain in Surabaya especially Den V 1. Therefore to continuous surveillance of circulating viruses is required to predict the risk of DHF and DF.
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Martina, Siska Evi, Cicilia Nony Ayu Bratajaya, and Ernawati Ernawati. "Dengue hemorrhagic fever: Knowledge, attitude, and practice in Palmeriam, Jakarta, Indonesia." GHMJ (Global Health Management Journal) 2, no. 1 (February 28, 2018): 9. http://dx.doi.org/10.35898/ghmj-21184.
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Background: Dengue hemorrhagic fever (DHF) is the most rapidly spreading mosquito-borne viral disease in the world. It is an emerging disease, episodic and occurring annually. Aims: This study was to examine the knowledge, attitude, and practice of community in Palmeriam, Jakarta regarding dengue hemorrhagic fever.Methods: A community-based cross-sectional study was designed in this study between June to July 2016. Purposive sampling was done to collect data from 148 respondents.Results: This study found that average age was 47 years old, 75% were women, and 46.6% finished secondary high school. In another hand, 23.6% respondents had good knowledge, and 49.3% had a neutral attitude for preventing dengue hemorrhagic fever. The study found that 68.2% respondents had a mid-level of practice prevention dengue hemorrhagic fever and it can be improved. This study indicated that the community was quite familiar with Dengue hemorrhagic fever, but there was confusion about water storage and environment effect.Conclusion: Health promotion program and community participation should improve dengue awareness. Continuous campaign for enhancing the knowledge and attitude would result in better practice for DHF prevention.
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Nhita, Fhira, Didit Adytia, and Aniq Atiqi Rohmawati. "Boosting Methods For Dengue Incidence Rate Prediction in Bandung District." Lontar Komputer : Jurnal Ilmiah Teknologi Informasi 13, no. 3 (December 13, 2022): 185. http://dx.doi.org/10.24843/lkjiti.2022.v13.i03.p05.
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Dengue infections are among the top 10 diseases that cause the most deaths worldwide. Dengue is a severe global threat and problem, especially in tropical countries like Indonesia. The Indonesian Ministry of Health also stated that dengue is as dangerous as COVID-19. One of the preventive actions that can be taken is by controlling vectors (the Aedes aegypti mosquito) where weather factors influence their breeding. In this study, the prediction of dengue incidence rate is carried out using three boosting methods i.e., Extreme Gradient Boosting, Adaptive Boosting, and Gradient Boosting. The data used are monthly data of dengue incidence rate and weather data. The case study used is Bandung district, West Java Province, Indonesia. The important issues that is investigated in this study is to find the weather parameters that have the most influence on IR and gradually improve the prediction model through three test scenarios. From the test results, the weather parameter that has the most influence on the next month's IR is temperature. Meanwhile, the best training data length is five years (2016-2020). Finally, the best prediction model achieved by AdaBoost method with value of Root Mean Square Error and Correlation Coefficient for testing data (January-December 2021) are 0.55 and 0.95, respectively.
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Suwantika, Auliya Abdurrohim, Woro Supadmi, Mohammad Ali, and Rizky Abdulah. "Cost-effectiveness and budget impact analyses of dengue vaccination in Indonesia." PLOS Neglected Tropical Diseases 15, no. 8 (August 12, 2021): e0009664. http://dx.doi.org/10.1371/journal.pntd.0009664.
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Despite the fact that the incidence and mortality rates due to dengue virus (DENV) infection in Indonesia are relatively high, dengue vaccination has not yet been introduced. This study aimed to analyse the cost-effectiveness and the budget impact of dengue vaccination in Indonesia by taking the potential of pre-vaccination screening into account. An age-structured decision tree model was developed to assess the cost-effectiveness value by applying a single cohort of 4,710,100 children that was followed-up in a 10-year time horizon within a 1-year analytical cycle. The budget impact was analysed in a 5-year period (2020–2024) by considering provinces’ readiness to introduce dengue vaccine and their incidence rate of DENV infection in the last 10 years. Vaccination that was coupled with pre-vaccination screening would reduce dengue fever (DF), dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS) by 188,142, 148,089 and 426 cases, respectively. It would save treatment cost at $23,433,695 and $14,091,642 from the healthcare and payer perspective, respectively. The incremental cost-effectiveness ratios (ICERs) would be $5,733 and $5,791 per quality-adjusted-life-year (QALY) gained from both perspectives. The most influential parameters affecting the ICERs were probability of DENV infection, vaccine efficacy, under-reporting factor, vaccine price, case fatality rate and screening cost. It can be concluded that dengue vaccination and pre-vaccination screening would be cost-effective to be implemented in Indonesia. Nevertheless, it seems unaffordable to be implemented since the total required cost for the nationwide vaccination would be 94.44% of routine immunization budget.
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Rantam, Fedik. "Serotype Infectivity and Phylogenetic of Dengue Virus cause of Dengue Fever (DF), Dengue Hemorrhagic Fever (DHF), and Dengue Shock Syndrome (DSS) in Surabaya- Indonesia." Journal of Stem Cell Research and Tissue Engineering 4, no. 1 (August 26, 2020): 1. http://dx.doi.org/10.20473/jscrte.v4i1.21588.
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Infection with DENV causes a spectrum of clinical disease ranging. The aim of this study is to investigate the infectivity of DENV with degree of severity dengue infection in Surabaya. Dengue infection was established by IgM anti dengue, and two step multiplex RT PCR and Nucleotide sequence. Grading of degree severity infection follow the WHO criteria 2011. DSS cases found 3 from 36 patients caused by DENV 2. The most uninfective was DENV 1, and the most prevalence dengue infection caused by DENV 3. The infectivity of dengue infection shown 16 patients lead to severity with plasma leakage. All of sera patients detecting using multiplex RT-PCR were positive, but it were analyzed using Duo ELISA only 22 serum sera positive IgM and IgG from 36 sera. . The Phylogenetic analysis indicates that the isolates from 2011 to 2012 close related with dengue isolate from 1998 and belong to 2009 to 2020.In this study it indicates that DENV 2 predominantly is the cause of DSS.
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Chamidah, Dina. "Prevalensi Dengue Pada Mahasiswa Universitas Surabaya." Jurnal Ilmiah Kedokteran Wijaya Kusuma 6, no. 1 (March 2, 2018): 45. http://dx.doi.org/10.30742/jikw.v6i1.334.
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In Indonesia, dengue fever is still common. This has caused many troubled people in Indonesia including Surabaya, East Java. Clinical signs of dengue start from mild illness to life-threatening shock syndrome. So it takes a development of a treatment to combat dengue fever. The purpose of this study is to see the prevalence of dengue fever in students. The prevalence of dengue fever at the University of Surabaya accounted for 17%, as we approached 81 people among them 14 were infected with dengue hemorrhagic fever. There were 42 (65%) people suffering from headaches, 19 (29%) joints, 26 (40%) muscle pain and 16 (25%) had abdominal pain, and from 64 among the 18-23 age group. The data obtained is helpful in determining the therapeutic approach to infections that appear. Furthermore, demographic factors such as age, gender, socioeconomic status with dengue virus transmission are also being considered.
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Pasaribu, Ayodhia Pitaloka, Tsheten Tsheten, Muhammad Yamin, Yulia Maryani, Fahmi Fahmi, Archie C. A. Clements, Darren J. Gray, and Kinley Wangdi. "Spatio-Temporal Patterns of Dengue Incidence in Medan City, North Sumatera, Indonesia." Tropical Medicine and Infectious Disease 6, no. 1 (March 5, 2021): 30. http://dx.doi.org/10.3390/tropicalmed6010030.
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Dengue has been a perennial public health problem in Medan city, North Sumatera, despite the widespread implementation of dengue control. Understanding the spatial and temporal pattern of dengue is critical for effective implementation of dengue control strategies. This study aimed to characterize the epidemiology and spatio-temporal patterns of dengue in Medan City, Indonesia. Data on dengue incidence were obtained from January 2016 to December 2019. Kulldorff’s space-time scan statistic was used to identify dengue clusters. The Getis-Ord Gi* and Anselin Local Moran’s I statistics were used for further characterisation of dengue hotspots and cold spots. Results: A total of 5556 cases were reported from 151 villages across 21 districts in Medan City. Annual incidence in villages varied from zero to 439.32 per 100,000 inhabitants. According to Kulldorf’s space-time scan statistic, the most likely cluster was located in 27 villages in the south-west of Medan between January 2016 and February 2017, with a relative risk (RR) of 2.47. Getis-Ord Gi* and LISA statistics also identified these villages as hotpot areas. Significant space-time dengue clusters were identified during the study period. These clusters could be prioritized for resource allocation for more efficient prevention and control of dengue.
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Siregar, Deborah, Ni Gusti Ayu Eka Sulistiyaningtyas, Yenni Ferawati Sitanggang, and Peggy Sara Tahulending. "Menggalakkan Program Pemberantasan Sarang Nyamuk (PSN) 3M Plus." JURNAL KREATIVITAS PENGABDIAN KEPADA MASYARAKAT (PKM) 5, no. 3 (March 2, 2022): 711–17. http://dx.doi.org/10.33024/jkpm.v5i3.5130.
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ABSTRAK Demam Berdarah Dengue masih menjadi salah satu masalah kesehatan masyarakat di Indonesia. Demam Berdarah Dengue merupakan penyakit endemik yang muncul sepanjang tahun terutama pada musim hujan di berbagai daerah tropis dan subtropis termasuk di Indonesia Penyakit ini berhubungan dengan keadaan lingkungan dan perilaku masyarakat. Tidak ada pengobatan khusus untuk DBD. Pencegahan dan pengendalian dengue bergantung pada tindakan pengendalian vektor yang efektif. Strategi pencegahan dan pengendalian demam berdarah membutuhkan keterlibatan masyarakat. Oleh karena itu penting dilakukan pendidikan kesehatan kepada masyarakat mengenai pencegahan Demam Berdarah Dengue dengan Menggalakkan Program Pemberantasan Sarang Nyamuk 3M Plus. Metode yang dilakukan adalah webinar yang bertujuan untuk meningkatkan pengetahuan masyarakat Indonesia mengenai pencegahan dan penanggulangan penyakit Demam Berdarah Dengue. Kegiatan ini dilakukan bulan September 2020 dan jumlah peserta webinar adalah 152 peserta. Hasil yang didapatkan dari kegiatan ini adalah jumlah peserta yang pernah mengalami DBD sebanyak 27 orang dan yang tidak pernah mengalami DBD sebanyak 125 orang. Peserta juga diminta untuk mengikuti pretest dan postest saat webinar. Hasil pengetahuan peserta sebelum webinar adalah 6.8 dan sesudah webinar adalah 7.4. Jadi dapat disimpulkan bahwa pengetahuan peserta meningkat setelah mengikuti webinar. Saran dari peserta webinar adalah agar kegiatan pendidikan kesehatan melalui webinar dapat dilakukan secara berkelanjutan. Kata kunci:Demam Berdarah Dengue, PSN 3M Plus, Webinar DBD. ABSTRACTDengue Hemorrhagic Fever is still a public health problem in Indonesia. Dengue Hemorrhagic Fever is an endemic disease that appears throughout the year, especially during the rainy season in various tropical and subtropical regions, including Indonesia. Dengue Hemorrhagic Fever is related to environmental conditions and community behavior. There is no specific treatment for dengue. Dengue prevention and control depends on effective vector control measures. Dengue fever prevention and control strategies require community engagement. Therefore, it is important to provide health education to the public regarding the prevention of Dengue Hemorrhagic Fever by promoting the 3M Plus Campaign. The method used was a virtual seminar that aimed to increase the knowledge of the community regarding the prevention and control of Dengue Hemorrhagic Fever. This seminar was done in September 2020 with 152 participants. The results obtained were 27 participants who had experienced Dengue Hemorrhagic Fever and 125 people who had never experienced Dengue Hemorrhagic Fever. Participants were also asked to take a pretest and posttest during the virtual seminar. The result of participants' knowledge before the virtual seminar were 6.8 and after the virtual seminar was 7.4. So, it can be concluded that participants' knowledge increased after attending the virtual seminar. Keywords: Dengue Hemorrhagic Fever, 3M Plus Campaign, Virtual Seminar DHF
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Almurdi, Almurdi, Ellyza Nasrul, Efrida Efrida, and Nuzulia Irawati. "Detection of Multiple Dengue Infections by Rt-qPCR in West Sumatera, Indonesia." Open Access Macedonian Journal of Medical Sciences 8, A (May 5, 2020): 311–16. http://dx.doi.org/10.3889/oamjms.2020.4343.
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BACKGROUND: Dengue is a disease caused by four distinct serotypes of dengue virus (DENV 1-4). DENV serotype differs from one another by 25–40% at the amino acid level. The detection of serotype is very important due to the fact that in secondary infection with heterologous serotype often leads to life threatening, dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS); likewise, an infection caused by two serotypes or more in one individual can contribute to the severity of infection.
AIMS: The aims of the study were to detect the multiple dengue serotypes infection by quantitative reverse transcription polymerase chain reaction (Q-RT-PCR) and to determine the viral load in dengue infection.
MATERIALS AND METHODS: This study applied the molecular examination for determining the serotype and viral load of DENV. The data were analyzed using Student’s t-test.
RESULTS: A total of 119 samples, 91 samples showed positive dengue infection after amplification. The multiple dengue infection was found in 47 samples and 44 samples with single infection. There was a significant difference between the number of viral load DENV-2 and DENV-1 infection (p = 0.000).
CONCLUSION: Two or more serotypes of dengue were found to infect a patient in West Sumatra. DENV-2 serotype was found predominantly in West Sumatra (n = 36, 39.56%) in patients with single infection. The molecular detection of dengue RNA by RT-PCR is a sensitive, rapid, and simple method. The RT-PCR method can detect the multiple dengue infection in clinical samples.