Relevant bibliographies by topics / Dengue

Academic literature on the topic 'Dengue'

Author: Grafiati
Published: 4 June 2021
Last updated: 28 July 2024

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Journal articles on the topic "Dengue"

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Bhavya, M., M. Ramya, N. Nagarjun, Nagarathna Amresh, and Balasubramanian Sathyamurthy. "Docking study of Selected Vinis vitifera seeds constituents on Dengue viral proteins – An In Silico approach." Indian Journal of Pharmaceutical and Biological Research 6, no. 04 (December 31, 2018): 25–31. http://dx.doi.org/10.30750/ijpbr.6.4.5.

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Dengue is a mosquito-borne systemic viral infection caused by any of the four antigenically related dengue viruses (DENV).The dengue virus belongs to the Flaviviridae family of viruses that cause diseases in humans.A virtual screening analysis of phytochemical structures with dengue virus protein targets has been carried out using a molecular docking approach with vins vinifera seeds. Grapes (Vinis vitifera) are believed to have health benefits due to their antioxidant activity and polyphenols. In this study we examined the binding affinities of 14 ligands with seven non structural Dengu viral proteins through In Silico methods like virtual screening and docking process which showed that compound F and compound N had high binding efficiencies with these proteins along with the type of hydrogen bonds and their respective amino acid residues at their docked sites.
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Hà, Văn Lực, Văn Trầm Tạ, and Văn Khoa Lê. "ĐẶC ĐIỂM LÂM SÀNG VÀ KẾT QUẢ ĐIỀU TRỊ SỐC SỐT XUẤT HUYẾT DENGUE Ở TRẺ DƯ CÂN, BÉO PHÌ TẠI CẦN THƠ." Tạp chí Y Dược học Cần Thơ, no. 74 (May 27, 2024): 180–86. http://dx.doi.org/10.58490/ctump.2024i74.2626.

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Đặt vấn đề: Trẻ em dư cân, béo phì có nguy cơ nhiễm virus Dengue cao hơn và là một trong những yếu tố có liên quan đến liên lượng tái sốc của sốt xuất huyết Dengue. Mục tiêu nghiên cứu: Khảo sát các đặc điểm lâm sàng và mô tả kết quả điều sốc sốt xuất huyết Dengue ở trẻ dư cân, béo phì tại Cần Thơ năm 2022-2024. Đối tượng và phương pháp nghiên cứu: Mô tả cắt ngang có phân tích trên 60 trẻ sốc sốt xuất huyết Dengue có dư cân, béo phì tại Cần Thơ năm 2022-2024. Kết quả: Trẻ từ 6 đến 12 tuổi chiếm tỷ lệ cao nhất (76,3%). Có 10 trường hợp sốc sốt xuất huyết Denuge nặng, chiếm 17%. Tổng lượng dịch truyền trung bình là 170,9 ± 58,7 ml/kg, thời gian truyền dịch trung bình là 35,0 ± 7,5 giờ. Có đến 55% trường hợp phải dùng cao phân tử. Có đến 29 trường hợp tái sốc, chiếm tỷ lệ 48,3%. Đa số bệnh nhân hồi phục sau khi được điều trị. Kết luận: Đa số bệnh nhi sốc sốt xuất huyết Dengue có dư cân, béo phì nhập viện tại Bệnh viện Nhi Đồng Cần Thơ đều hồi phục và khỏi bệnh.
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Martins, Hafra Kelly Pessoas, Pâmela Pereira Lima, Mara Glecia Costa Lacerda, Renata da Silva Santos Aquino, and Kelúria Brito Honório Torres. "DISTRIBUIÇÃO DOS CASOS NOTIFICADOS DE DENGUE NO ESTADO DO PIAUÍ." REVISTA FOCO 17, no. 6 (June 20, 2024): e5191. http://dx.doi.org/10.54751/revistafoco.v17n6-094.

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A dengue assume atualmente um papel proeminente entre as doenças arbovirais de relevância epidemiológica global. O presente estudo tem como objetivo descrever o número de notificações de dengue nos últimos cinco anos no estado do Piauí.Trata-se de uma pesquisa descritiva, transversal, de cunho quantitativo, realizada por meio de busca na base de dados DATASUS e Sinan, referentes às notificações de agravos compulsórios nos anos de 2020 a 2024, no estado do Piauí. Além disso, foi consultado o banco de dados da Scielo para embasar teoricamente a pesquisa, utilizando os descritores "dengues", "emergências" e "infecção pelo vírus da dengue", com a associação dos termos através dos operadores booleanos "and" e "or". Nos anos observados, foram identificadas 54521 notificações de casos de dengue em uma população de 3 milhões de habitantes. Evidencia-se a significativa distribuição da dengue no estado do Piauí, com o ano de 2022 apresentando a maior notificação. Esta rede de transmissão apresenta-se como um gráfico de ondulação, onde o fator determinante deste evento não é facilmente constatável através das notificações.Apesar da alta incidência da transmissão deste vírus, é imprescindível uma investigação minuciosa que correlacione essa incidência com fatores ambientais e climáticos, visando uma melhor compreensão da distribuição do vetor.
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Gubler, Duane J. "Dengue and Dengue Hemorrhagic Fever." Clinical Microbiology Reviews 11, no. 3 (July 1, 1998): 480–96. http://dx.doi.org/10.1128/cmr.11.3.480.

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SUMMARY Dengue fever, a very old disease, has reemerged in the past 20 years with an expanded geographic distribution of both the viruses and the mosquito vectors, increased epidemic activity, the development of hyperendemicity (the cocirculation of multiple serotypes), and the emergence of dengue hemorrhagic fever in new geographic regions. In 1998 this mosquito-borne disease is the most important tropical infectious disease after malaria, with an estimated 100 million cases of dengue fever, 500,000 cases of dengue hemorrhagic fever, and 25,000 deaths annually. The reasons for this resurgence and emergence of dengue hemorrhagic fever in the waning years of the 20th century are complex and not fully understood, but demographic, societal, and public health infrastructure changes in the past 30 years have contributed greatly. This paper reviews the changing epidemiology of dengue and dengue hemorrhagic fever by geographic region, the natural history and transmission cycles, clinical diagnosis of both dengue fever and dengue hemorrhagic fever, serologic and virologic laboratory diagnoses, pathogenesis, surveillance, prevention, and control. A major challenge for public health officials in all tropical areas of the world is to devleop and implement sustainable prevention and control programs that will reverse the trend of emergent dengue hemorrhagic fever.
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Ismaillya Noor, Roudhotul, Aryati Aryati, and Puspa Wardhani. "KETERKAITAN ANTIGEN NS1 INFEKSI VIRUS DENGUE DENGAN SEROTIPE VIRUS DENGUE." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 18, no. 2 (March 17, 2018): 87. http://dx.doi.org/10.24293/ijcpml.v18i2.1005.

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Dengue virus infection (DVI) currently is detected by using dengue virus NS1 antigen (NS1 Ag). The sensitivity of NS1 Ag is 27.8%–93.4%,but recent study of Kumarasamy the sensitivity of NS1 Ag is better than the virus isolation and polymerase chain reaction (PCR). This studyis focussed on the evaluation of the validity of Panbio Dengue Early Rapid for the diagnosis of DVI and the NS1 Ag sensitivity associated withdengue virus serotypes. The sera was obtained from 65 DVI patients which diagnosed by the clinicians. The resulted diagnosis was foundby serology tests (positive IgM/IgG antidengue/NS1 Ag ELISA) and 1997 WHO criteria as the gold standard, and which also found 35 nonDVI patients (typhoid fever, HAV, malaria, UTI, tuberculosis and bronchopneumonia). The samples were examined by Panbio Dengue EarlyRapid. PCR was performed on each positive serological test result to determine the dengue virus serotypes. The sensitivity and specificity ofPanbio Dengue Early Rapid was 49.2% and 100%. The PCR results of 65 sera showed positive PCR in 49.2% (positive NS1 Ag was 62.5%).Meanwhile, and negative PCR in 50.8% (positive NS1 Ag was 36.4%). The predominance of serotypes (positive NS1 Ag) were DEN-3 (37.5%),DEN-4 (28.1%), DEN-1 (21.9%) and DEN-2 (12.5%). The Panbio Dengue Early Rapid can be used as early detection of DVI, although itshould be used in conjunction with other dengue serological tests as well. Unfortunately there is still not enough evidence about the NS1 Agsensitivity associated with the dengue virus serotypes.
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Hapsari, Lutfiana Inda, Nonik Eka Martyastuti, and Erwin Lestyaningsih. "Implementasi Kompres Hangat pada Pasien Anak DHF (Dengue Haemorhagic Fever) dengan Hipertermi di Ruang Flamboyan RSUD Batang." Pena Medika Jurnal Kesehatan 12, no. 2 (January 4, 2023): 259. http://dx.doi.org/10.31941/pmjk.v12i2.2585.

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<p><strong>Latar belakang : </strong><em>Dengue Haemoragic Fever</em> (DHF) atau yang biasa disebut dengan penyakit Demam Berdarah Dengue (DBD) merupakan penyakit yang disebabkan karena infeksi virus dengue yang ditularkan melalui gigitan nyamuk Aedes aegepty yang dapat memicu terjadinya demam atau hipertermi (Nuryanti, dkk. 2022). Menurut WHO pada tahun 2019 jumlah kasus Dengu fever dilaporakan sebanyak 5,2 juta kasus. Demam Berdarah Dengue (DBD) di Indonesia hingga Juli 2019 mencapai 71.633 kasus dan 541 diantaranya meninggal dunia (Kemenkes,2020). Di Jawa Tengah, Pada tahun 2019 Kasus DBD tecatat sebanyak 2.846 kasus (Dinkes Jateng Prov, 2019). Sedangkan di kabupaten Batang kasus DBD awal pada Juni 2022 sebanyak 8 kasus dengan korban meninggal dunia sebanyak tiga orang. sebanyak (Dinkes Batang, 2022). <strong>Tujuan : </strong>Mampu menerapkan implementasi kompres hangat pada pasien anak dengan <em>Dengue Haemoragic Fever</em> (DHF) secara komprehensif.<strong> Metode : </strong>Metode yang digunakan dalam studi kasus ini adalah metode dekriptif dengan pendekatan studi kasus melalui pemberian asuhan keperawatan. <strong>Hasil : </strong>Setelah dilakukan implementasi kompres hangat pada pasien anak hipertermi dengan DHF selama 3x24 jam masalah hipertermi dapat teratasi. <strong>Simpulan : </strong>Kompres hangat dapat menrurunkan hipertermi pada anak<strong> </strong>dengan DHF.</p>
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Naeem, Muhammad, Aneela Shaheen, Saima Batool, Sara Rubab, Tehmina Saba, Tooa Riaz, and M. Arshad Mahmood. "DENGUE FEVER." Professional Medical Journal 21, no. 02 (December 6, 2018): 243–46. http://dx.doi.org/10.29309/tpmj/2014.21.02.1972.

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Background: Dengue is the most prevalent mosquito-born viral illness in theworld. Clinically dengue ranges from asymptomatic, non-febrile illness, classic dengue todengue hemorrhagic fever/dengue shock syndrome. Objective: Subjects & Methods: Thisstudy was included 79 patients conducted at Nawaz Sharif Social Sevurity Hospital, Lahoreduring the epidemic of dengue in Lahore from September 2011 to Dec 2011. Results: Twenty outof 79 patients suspected of dengue fever were dengue IgM positive. Male to female ratio was1.19: 1. Our study included 79 patients suspected of having dengue fever. Fever was the mostcommon symptom in these patients. Conclusions: Early identification of dengue with risk ofdeveloping hemorrhage is an important clinical objective. The morbidity and mortality can bereduced by appropriate and judicious treatment of dengue patients.
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Livingston, P. G., I. Kurane, L. C. Dai, Y. Okamoto, C. J. Lai, R. Men, S. Karaki, M. Takiguchi, and F. A. Ennis. "Dengue virus-specific, HLA-B35-restricted, human CD8+ cytotoxic T lymphocyte (CTL) clones. Recognition of NS3 amino acids 500 to 508 by CTL clones of two different serotype specificities." Journal of Immunology 154, no. 3 (February 1, 1995): 1287–95. http://dx.doi.org/10.4049/jimmunol.154.3.1287.

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Abstract Dengue virus infections are a major cause of morbidity and mortality in tropical and subtropical areas of the world. We analyzed dengue virus-specific CD8+ CD4- CTL at the clonal level to further understand the role of CD8+ CTL in dengue virus infections. Dengue virus-specific CD8+ CTL clones were established from lymphocytes of a dengue 4-immune adult. Three patterns of dengue serotype specificities were identified: 1) specific for dengue 4, 2) cross-reactive for dengue 2 and dengue 4 (subcomplex-specific); and 3) cross-reactive for all four dengue virus serotypes. Three dengue 4-specific clones and one dengue 2/dengue 4 cross-reactive clone were further analyzed. All four of the clones were HLA-B35 restricted and recognized NS3. The epitopes were mapped to amino acids (aa) 483 to 618 of NS3. The epitope was then defined by using synthetic peptides. Three dengue 4-specific clones and one dengue 2/dengue 4 cross-reactive clone recognized the same peptide (TPEGIIPTL) encompassing aa 500 to 508 of dengue 4 NS3. The peptide encompassing aa 500-508 of dengue 2 NS3 was recognized by a dengue 2/dengue 4 cross-reactive clone but was not recognized by the dengue 4-specific clones. Dengue 4-specific and dengue 2/dengue 4 cross-reactive clones used different TCR. These results indicate that CD8+ CTL clones that use different TCR and demonstrate two distinct serotype specificities recognize the same 9-mer peptide in the context of HLA-B35.
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A, Ravi Teja. "Sonographic Eye on Dengue during Clinical Evaluation and Early Diagnosis in Children." Pediatrics & Neonatal Biology Open Access 4, no. 2 (2019): 1–4. http://dx.doi.org/10.23880/pnboa-16000142.

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The study was done during epidemic of dengue in South India tertiary paediatric Hospital during 2019, for a period of one mon th. Role of ultrasound in early identification of dengue and its complications along with clinical and laboratory investigations. Ultrasound was performed on 112 patients (1 – 14 years) referred from dept. of paediatrics for ultrasound with features of dengu e and its complication and later confirmed the diagnosis with serology proven. 30 patients were serologically negative for dengue fever hence excluded from the study. Out of 92 serologically positive cases 31 cases visited hospital at early stage and under gone ultrasound during 2/3 rd day and 5/7 th day of fever. During 2/3 rd day ultrasound showed as almost all showed gall bladder wall thickening and pericholecystic fluid (in different patterns), 32.5% had hepatomegaly, 16.12% had splenomegaly and 19.35% righ t minimal pleural effusion, 3.25% left plural effusion. Follow - up ultrasound on fifth to seventh day revealed ascites in 93.5%, hepatomegaly in 90.3%, right plural effusion 80.6%, left pleural effusion in 41.9% and pericardial effusion in 29%. Of the 61 pa tients who underwent the study on fifth to seventh day of fever for the first time almost all had gall bladder wall thickening, 95.0%had hepatomegaly, 27.8% had splenomegaly, 96.7% had ascites, 95.08% had right pleural effusion, 75.4% had left pleural effu sion and 22.9% had pericardial fluid. To conclude, in an epidemic of dengue, ultrasound features of thickened gall bladder wall, pleural effusion heaptomegaly and ascites should strongly favour the diagnosis of dengue fever.
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Cabezas, César, Femando Donaires, and Paquita Garcla. "Dengue." Diagnóstico 56, no. 1 (December 13, 2018): 37–44. http://dx.doi.org/10.33734/diagnostico.v56i1.121.

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Desde su ingreso al Perú en 1990, el dengue sigue constituyendo y cada vez más un serio problema de salud pública. Esta enfermedad es causada por el virus del dengue que tiene 4 serotipos, además de subtipos en cada serotipo y el Aedes aegypti es el principal vector, que está presente en la costa desdeTumbes hasta Arequipa y su ubicuidad está en razón a determinantes sociales y ambientales. La OMS ha instaurado una nueva clasificación de la enfermedad como dengue con o sin signos de alarma y dengue grave, lo cu.al está facilitando tanto el diagnóstico y la orientación para el manejo. El control vectorial del Aedes aegypti es fundamental en la prevención y control del dengue.
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Dissertations / Theses on the topic "Dengue"

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Borba, Luana de. "Dengue." reponame:Repositório Institucional da UFPR, 2011. http://hdl.handle.net/1884/26058.

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Paula, Eduardo Vedor de. "Dengue." reponame:Repositório Institucional da UFPR, 2013. http://hdl.handle.net/1884/1879.

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Tison, Laurence. "La dengue." Bordeaux 2, 1995. http://www.theses.fr/1995BOR2P091.

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Correa, Paulo Roberto Lopes. "Dengue e dengue hemorrágico em Belo Horizonte, 1996 - 2001." Universidade Federal de Minas Gerais, 2003. http://hdl.handle.net/1843/ECJS-84NP6V.

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Prevention and control of dengue and hemorrhagic dengue, currently the arbovirosis of greatest impact in terms of morbimortality in the population, depend basically on the reduction of the disease´s vector´s population in the domicile and peridomicile, the main locations where the transmission of the disease occurs. In order to analyze the occurrence of dengue in the city of Belo Horizonte and its relation with infestation rates of Aedes aegypti in the city´s buildings between the years 1996-2001, the building infestation rates IP (proportion of buildings which are positive for the vector´s larvae) were analyzed, grouped according to the quartile distribution for each coverage area of the basic health units of the city. The average monthly incidence rates of the disease according to the month subsequent to the vector research were also analyzed. It was verified that Belo Horizonte recorded its first cases of the disease in 1996-1997, with serotype DEN-1 circulation and 7% vector infestation in the first semester of 1996 and 5% in October 1997. In the first semester of 1998, there was an epidemic of great magnitude, with over 86,000 cases reported (annual incidence rate of 4,085 cases per 100,000 inhabitants) and cocirculation of serotypes DEN-1 and DEN-2, with 34 cases of hemorrhagic dengue and 3 deaths reported. After a period of low viral circulation between 1999-2000, over 4,000 cases were confirmed in 2001 and ten cases of hemorrhagic dengue. During the analyzed period, 17 vector researches were carried out in the city, with values between 7.8% (first semester of 1997) and 0.3% (October 2000). The coverage areas with IP between 0.46% and 1.32% (2nd quartile) presented, in relation to the areas with IP under 0.46% (1st quartile), average monthly incidence rates twice as high. For the areas with IP between 1.33% and 2.76% (3rd quartile) and IP higher or equal to 2.77%, the incidence rates were respectively 5 and 7 times higher in relation to the areas with IP under 0.46 %. It is important to point out that, even with IP close to zero, there was viral transmission in the city, which indicates the limitations in this method of vector research for predicting dengue epidemics. The importance of viral monitoring and entomological surveillance are discussed, along with fundamental strategies to guide actions for disease control so as to minimize the social impact that dengue brings to the population.
A prevenção e controle da dengue e da dengue hemorrágica, atualmente a arbovirose de maior impacto em termos de morbimortalidade na população, dependem fundamentalmente da redução da população do vetor da doença no domicílio e peridomicílio, principais locais nos quais ocorre a transmissão da doença. Para analisar a ocorrência da dengue em Belo Horizonte e sua relação com os índices de infestação do Aedes aegypti nos imóveis da cidade entre os anos de 1996-2001, foram analisados os índices de infestação predial - IP (proporção de imóveis prediais positivos para larvas do vetor) agrupados de acordo com a sua distribuição em quartis para cada uma das áreas de abrangência das unidades básicas de saúde do município e as respectivas taxas de incidência médias mensais da doença referentes ao mês subsequente à pesquisa vetorial. Verificou-se que Belo Horizonte registrou os primeiros casos da doença em 1996-1997, com circulação do sorotipo DEN-1 e uma infestação vetorial de 7% no primeiro semestre de 1996 e 5% em outubro de 1997. No primeiro semestre de 1998, ocorreu uma epidemia de grande magnitude, com mais de 86 mil casos registrados (taxa de incidência anual de 4.085 casos por 100 mil habitantes) e a cocirculação dos sorotipos DEN-1 e DEN-2, com 34 casos de dengue hemorrágico e três óbitos registrados. Após um período de baixa circulação viral em 1999 e 2000, foram confirmados mais de 4.000 casos em 2001 e dez casos de dengue hemorrágica. No período analisado, foram realizadas 17 pesquisas vetoriais no município, com valores entre 7,8% (primeiro semestre de 1997) a 0,3% (outubro de 2000). As áreas de abrangência com IP entre 0,46 e 1,32% (2.º quartil) apresentaram, em relação às áreas com IP menor ou igual a 0,45% (1.º quartil), taxas de incidência mensal média da doença duas vezes maiores. Para as áreas com IP entre 1,33 e 2,76% (3.º quartil) e IP maior ou igual a 2,77%, as taxas de incidência foram, respectivamente, 5 e 7 vezes maiores em relação às áreas com IP menor ou igual a 0,45% É importante destacar que, mesmo com IP próximos a zero, ocorreu transmissão viral no município, indicando as limitações deste método de pesquisa vetorial para predição de epidemias de dengue. Discute-se a importância do monitoramento viral e da vigilância entomológica, estratégias fundamentais para orientar as ações de controle da doença, minimizando os impactos sociais que a dengue acarreta na população.
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Brito, Carlos Alexandre Anturnes de. "Dengue em Recife, Pernambuco: padrões clínicos, epidemiológicos, laboratoriais e fatores de risco associados à forma grave da doença." reponame:Repositório Institucional da FIOCRUZ, 2007. https://www.arca.fiocruz.br/handle/icict/3908.

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A tese será apresentada no formato de um capítulo de livro e quatro artigos para periódico. O capítulo do livro intitulado: Dengue e Febre Hemorrágica da Dengue, teve como objetivo realizar uma atualização do tema visando subsidiar os profissionais de saúde no suporte ao paciente com dengue. O primeiro artigo intitulado: Acute disseminated encephalomyelitis in classic dengue teve por objetivo divulgar uma forma incomum de acometimento da doença e já está aceito para publicação. O segundo artigo intitulado: Evidência de alterações de permeabilidade vascular na dengue: quando a dosagem de albumina sérica define o quadro? apresenta uma série de casos de FHD estudados retrospectivamente com o objetivo de sistematizar as características clínicas dos casos e os exames laboratoriais relevantes para o seu acompanhamento e diagnóstico clínico. Esse estudo já foi aceito para publicação Revista Brasileira de Medicina Tropical. A partir de uma coorte iniciada em 2003, em Recife-PE, objetivando o desenvolvimento de vacina contra dengue e a identificação de marcadores prognósticos apresentaremos o terceiro e quarto artigos. A população do estudo foi composta por voluntários recrutados no serviço de urgência de dois hospitais gerais privados da cidade, Hospital Santa Joana e Hospital Esperança e um hospital de pediatria público o Instituto Materno Infantil Professor Fernando Figueira (IMIP). Os médicos do plantão ao identificarem um caso suspeito seguiam o protocolo de atendimento aos pacientes com dengue do Ministério da Saúde (MS 2003), avaliando o paciente clinica e laboratorialmente no primeiro dia do atendimento e subseqüentemente quando necessário. Amostras de sangue eram coletadas na fase aguda da doença, na convalescença e após 6 meses. O terceiro artigo intitulado: Dengue: perfil clínico-epidemiológio, laboratorial e avaliação de fatores de risco em uma coorte prospectiva entre pacientes adultos em Recife, Nordeste do Brasil teve como objetivo descrever o padrão clínico-epidemiológicos dos casos de dengue entre maiores de 14 anos e identificar fatores de riscos associados a FHD. Como objetivo secundário analisouse as características que diferenciam os casos de dengue clássica (DC) daqueles de infecção dengue-like (IDL). O quarto artigo intitulado: Padrões clínicos de dengue e FHD na cidade do Recife, Brasil: uma comparação entre crianças e adultos tem objetivo descrever o padrão de apresentação na faixa etária pediátrica comparando com adultos
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Prates, John Willians Oliveira. "Expressão das proteínas não-estrutural 1 (NS1) dos vírus Dengue-1, Dengue-3 e Dengue-4 em Pichia pastoris." Universidade Federal de Viçosa, 2017. http://www.locus.ufv.br/handle/123456789/21431.

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A dengue é uma doença amplamente distribuída pelo mundo, e representa um grande problema de saúde pública em vários países. As manifestações clínicas podem variar desde uma síndrome viral inespecífica e benigna, até um quadro grave e fatal de doença hemorrágica com choque. O diagnóstico na sua fase inicial é muito importante, pois auxilia no tratamento sintomático do paciente e na adoção de medidas para o controle do vetor, prevenindo a dispersão da doença. Nesse contexto, a detecção de antígenos virais, especialmente a proteína não estrutural 1 (NS1), é uma alternativa muito eficaz para realizar o diagnóstico da dengue. Essa proteína é sintetizada pelas células infectadas, podendo ser detectada nos sobrenadantes das culturas ou no soro de pacientes infectados. Dessa forma, ela pode ser utilizada como antígeno para o desenvolvimento de kits de diagnóstico. No entanto, um grande problema no desenvolvimento de tais kits, consiste na obtenção desses antígenos, que geralmente é realizado por métodos caros, trabalhosos e de difícil execução. Nesse contexto, objetivou-se nesse trabalho utilizar um sistema de expressão eucariótico para produzir as proteínas NS1 dos vírus dengue-1, -3 e -4, e avaliar a sua antigenicidade. O gene otimizado da proteína NS1 do vírus dengue-4 foi clonado no plasmídeo pPICZαA, o qual foi utilizado para transformar leveduras Pichia pastoris por eletroporação. Posteriormente,a levedura transformada foi submetida á indução da expressão da proteína NS1. Outras duas leveduras transformadas, de maneira independente, com dois plasmídeos diferentes (pPICZαA/NS1DENV1 e pPICZαA/NS1DENV3) também foram induzidas a expressar as proteínas NS1 dos vírus dengue-1 e dengue-3. Proteínas de 60 kDa (NS1 DENV4), e duas de 50 kDa (NS1 DENV-1 e NS1 DENV-3) foram obtidas. Essas proteínas mostraram-se antigênicas no teste de Western Blot, demonstrando o seu potencial para serem utilizadas como antígenos para aplicações diagnósticas.
Dengue is a disease widely distributed throughout the world and represents a major public health problem in several countries. Clinical manifestations may range from a benign non-specific viral syndrome to severe and fatal hemorrhagic shock syndrome. The diagnosis in its initial phase is very important, since it assists in the symptomatic treatment of the patient and in the adoption of measures for the control of the vector, preventing the dispersion of the disease. In this context, detection of viral antigens, especially nonstructural protein 1 (NS1), is a very effective alternative for the diagnosis of dengue. This protein is synthesized by infected cells and can be detected in culture supernatants or in the serum of infected patients. In this way, it can be used as antigen for the development of diagnostic kits. However, a major problem in the development of such kits is the procurement of these antigens, which is usually accomplished by costly, laborious and difficult methods. In this context, the objective of this study was to use a eukaryotic expression system to produce the NS1 proteins of dengue-1, -3 and -4 viruses, and to evaluate their antigenicity. The optimized NS1 protein gene of the dengue-4 virus was cloned into the plasmid pPICZαA, which was used to transform Pichia pastoris yeasts by electroporation. Subsequently, the transformed yeast was subjected to the induction of NS1 protein expression. Two other yeasts independently transformed with two different plasmids (pPICZαA/NS1DENV1 and pPICZαA/ NS1DENV3) were also induced to express the NS1 proteins of the dengue-1 and dengue-3 viruses. Proteins of 60 kDa (NS1 DENV4) and two of 50 kDa (NS1 DENV1 and NS1 DENV3) were obtained. These proteins were shown to be antigenic in the Western Blot test, demonstrating their potential to be used as antigens for diagnostic applications.
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7

Rolim, Meire Luce Moreira. "ClÃnical and laboratorial aspects of patients with serious forms of affection in Fortaleza - CearÃ." Universidade Federal do CearÃ, 2005. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=337.

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FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgico
Dengue is an acute viral disease of varied clinical spectrum and of great epidemiological importance in Brazil, including Cearà being Fortaleza a district in which the magnitude of the problem consists in concentrating a larger number of severe cases of the state. This research is about a descriptive study and prospective of secondary data of 103 cases of dengue registered in Fortaleza. The general objective was to describe profile of the platelets counting and of the hematÃcrito correlating them with the clinical evolution and type immunological response of patients with severe cases of dengue in three hospitals this district in 2003. The data were collected from hospital files and were included only the cases confirmed by serology for the virus of dengue by ELISA technique. For statistic analysis we used the non-parametrical tests of Wilcoxon post addings. As a result we found out that: the low value of platelets (trombocytopenia) was known to all analyzed patients (the minimum value were varied from 13.000/mm to 75.000/mmÂ), with the decrease in the platelets counting from the first day in which the exam was done being more evident from the fifth to the eighth day of the evolution of the disease. The value of the hematÃcrito was instable during the days of the evolution of the disease with a higher average from the third to the sixth day. The maximum average value was of 44,5% presented by only 25% of the patients of the sub-sample. The first hemorrhagic manifestation occurred on the first day of the symptoms, being more elevated from the fifth to the seventh day, but after the tenth day of the disease no patient presented this manifestation. It was not established any relation between Trombocytopenia and hemorrhagic manifestations. There was no relation between secondary response and trombocytopenia nor with hemoconcentration but it was significant the relation with hemorrhagic or alert sign of hemoconcentration for the patients of the sub-sample. Primary immunological response to the virus of dengue was more present (72,3%) than the secondary response (27,7%). Unusual cases of dengue were identified in 06 (5,8%) of the patients of the sample, and probably were the most severe cases. The importance of these results consists of the available data analysis, allowing the knowledge of the severe forms of dengue in order to identify the early signs of gravity and the best way of monitoring. Nevertheless it is still necessary to know better the dynamic of the illness in our environment. Moreover it is necessary to assure the effective control of the illness, which is a problem of great seriousness especially in the big centers of our country.
Dengue à uma doenÃa viral, aguda, de variado espectro clÃnico e grande importÃncia epidemiolÃgica no Brasil, inclusive no CearÃ, sendo Fortaleza um municÃpio no qual a magnitude do problema consiste na concentraÃÃo do maior nÃmero de casos graves do estado. Esta pesquisa trata-se de um estudo descritivo, prospectivo de dados secundÃrio de 103 casos de dengue registrados em Fortaleza. O objetivo geral foi descrever o perfil da contagem de plaquetas e do hematÃcrito correlacionando-os com a evoluÃÃo clinica e tipo de resposta imunolÃgica de pacientes com formas complicadas de dengue internados em trÃs hospitais de Fortaleza em 2003. Os dados foram coletados dos prontuÃrios e somente foram incluÃdos os casos confirmados por sorologia para o vÃrus da dengue pela tÃcnica ELISA. Para anÃlise estatÃstica utilizou-se o teste nÃo paramÃtrico de soma dos postos de Wilcoxon. Como resultados obteve-se que: baixa contagem de plaquetas (trombocitopenia) foi comum a todos pacientes analisados (o valor mÃnimo variou de 13.000/mm a 75.000/mmÂ), com declÃnio na contagem de plaquetas a partir do primeiro dia que foi realizado o exame, sendo mais acentuado do 5 ao 8 dia de evoluÃÃo da doenÃa. O valor do hematÃcrito foi instÃvel durante os dias de evoluÃÃo da doenÃa, com a mÃdia mais elevada do 3 ao 6 dia. O valor mÃximo da mÃdia foi de 45.5%, apresentado por apenas 25% dos doentes da sub-amostra. A 1 manifestaÃÃo hemorrÃgica ocorreu desde o 1 dia do inÃcio dos sintomas, sendo mais elevada do 5 ao 7 dia; mas apÃs o 10 dia de evoluÃÃo da doenÃa nenhum paciente apresentou esta manifestaÃÃo. NÃo foi estabelecida relaÃÃo entre trombocitopenia e manifestaÃÃes hemorrÃgicas. NÃo houve relaÃÃo entre resposta imunolÃgica secundÃria e trombocitopenia, nem com hemoconcentraÃÃo, mas foi significante a relaÃÃo com hemorragia ou sinais de alerta para os pacientes da sub-amostra que hemoconcentraÃÃo. Resposta imunolÃgica primÃria ao vÃrus da dengue foi mais presente (72,3%) do que resposta secundÃria (27.7%). Formas nÃo usuais de dengue foram identificadas em 06 (5,8%) dos pacientes da amostra e provavelmente foram os casos mais graves. A importÃncia destes resultados consiste na anÃlise dos dados disponÃveis, contribuindo com o conhecimento do perfil das formas graves de dengue no que se refere à identificaÃÃo precoce dos sinais preditores de gravidade para o melhor monitoramento dos casos. No entanto, ainda sÃo necessÃrios estudos com o intuito de conhecer melhor a dinÃmica da doenÃa no nosso meio. Sobretudo, prescinde de polÃticas que assegurem o efetivo controle da dengue, que se configura um problema de grande severidade, em especial nos grandes centros do paÃs.
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Leite, Priscila Leal e. "Impacto da dengue no Brasil em período epidêmico e não epidêmico : incidência, mortalidade, custo hospitalar e disability adjusted life years (DALY)." reponame:Repositório Institucional da UnB, 2015. http://repositorio.unb.br/handle/10482/19264.

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Dissertação (mestrado)—Universidade de Brasília, Faculdade de Medicina, Núcleo de Medicina Tropical, 2015.
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Introdução: Apesar da crescente carga mundial da dengue, existem poucos estudos publicados que tenham avaliado a carga desta doença e que forneçam estimativas dos custos no Brasil. Métodos: Estudo de avaliação econômica parcial do tipo custo da doença sob a perspectiva econômica do gestor público e estudo descritivo da carga da dengue para o ano de 2010, maior ano epidêmico da doença no país, e 2012, ano não epidêmico. Calculamos as taxas de incidência, mortalidade, o Disability Adjusted Life Years (DALY) e os custos diretos de hospitalização, tendo como fonte de dados os sistemas oficiais de estatística, notificação e hospitalização. Para o cálculo dos Anos de Trabalho Perdidos (ATP), empregamos o valor do salário mínimo e do Produto Interno Bruto (PIB) para 2010 e 2012. Utilizou-se o modelo da Life-tableWest,do Global BurdenofDisease, para estimar o DALY. Resultados: Foram registrados 1.027.100 e 597.193 casos prováveis de dengue no Sinan em 2010 e 2012, respectivamente. A taxa de incidência foi 538,4/100.000 habitantes em 2010 e 313,1/100.000 habitantes em 2012. A mortalidade no período epidêmico foi duas vezes maior do que no período não epidêmico. Em 2010, foram 13.955 Anos de Vida Perdidos (AVP) por dengue e foram incorridos 74 DALYs/milhão por Dengue Clássico e 73 DALYs/milhão pelas Formas Graves. Em 2012, foram 7.297 Anos de Vida Perdidos (AVP) por dengue e incorridos 38 DALYs por Dengue Clássico e pelas Formas Graves. Foram estimados 151 Anos Vividos com Incapacidade (AVI) por dengue clássico e 37 AVI para as formas graves da doença, no ano epidêmico. Em 2010, o valor total gasto com hospitalização por dengue foi de R$33.498.386,22 e R$16.608.420,09 em 2012. Foram perdidos 8.244 anos de trabalho por dengue no ano epidêmico e 5.124 em 2012. Calculamos uma perda salarial de R$ 56.059.200,00 para os Anos de Trabalhos Perdidos (ATP) em 2010 e uma perda de produtividade total de R$ 156.767.904,00. Para 2012, obtivemos uma perda salarial de R$ 42.494.869,20 para os ATP e R$ 114.777.600,00 em perda de produtividade. Conclusão: Nos anos epidêmicos e não epidêmico, ocorreu um predomínio do sexo feminino, faixa etária de 20 a 59 anos e da forma clássica da doença. Os óbitos por dengue nos anos de 2010 e 2012 superam os óbitos no Brasil por malária, leishmaniose, esquistossomose, hanseníase e infecções meníngeas. Os custos diretos de hospitalização por dengue no Brasil no ano epidêmico foi duas vezes maior do que no ano não epidêmico. O resultado do DALY de dengue foi superior a outras doenças infecciosas em países em desenvolvimento, como malária e tuberculose. O DALY reflete parte do impacto causado por uma doença antiga, negligenciada e que causa mortes que são em sua grande maioria evitáveis. Estudos de impacto e carga da doença podem auxiliar no direcionamento dos recursos, de formação de profissionais capacitados para suspeição precoce da doença, disgnóstico laboratorial rápido e oportuno, bem como alocação de tecnologias em saúde. ___________________________________________________________________________ ABSTRACT
Introduction: Despite the growing global burden of dengue, there are few published studies that have evaluated the burden of this disease and provide cost estimates in Brazil. Methods: study economic evaluation of cost of illness from the economic perspective of the public manager of the Unified Health System (SUS) and descriptive study dengue load for the year 2010, the largest epidemic year of the disease in the country, and 2012 no epidemic year for dengue. We calculated incidence rates, mortality, Disability Adjusted Life Years (DALY) and direct hospitalization costs, with the data source the official statistical systems, notification and hospitalization. To calculate the Lost Years of Work (ATP), we used the minimum wage and the gross domestic product (GDP) for 2010 and 2012. We used the model of the Life-table West, the Global Burden of Disease to estimate the DALY. Results: Probable cases of dengue 1,027,100 were registered in Sinan in 2010 and 597,193 probable cases of dengue and 2012, respectively. The incidence rate was 538.4/100,000 population in 2010 and 313.1/100,000 population in 2012. Mortality in the epidemic period was two times higher than in non-epidemic period. In 2010, 13,955 Years of Life Lost (AVP) were incurred by dengue and 74 DALYs/million for Dengue Classic and 73 DALYs/million by the Forms Graves. In 2012, there were 7,297 Years of Life Lost (AVP) from dengue and 38 DALYs incurred by Dengue Classic and the Forms Graves. 151 Years Lived with Disability were estimated (AVI) for classic dengue and 37 AVI to severe forms of the disease in 2010, and 85 by AVI classic dengue-nine AVI to severe forms of the disease, in non-epidemic year. In 2010, the total amount spent on hospitalization for dengue was R$ 33,498,386.22 and R$ 16,608,420.09 in 2012. 8244 years of work by dengue epidemic were lost in the year and 5,124 in 2012. We estimate a wage loss R$ 56,059,200.00 for the Years of Lost Jobs (ATP) in 2010 and a total productivity loss of R$ 156,767,904.00. For 2012, we obtained a wage loss of R$ 42,494,869.20 for ATP and R$ 114,777,600.00 in lost productivity. Conclusion: In epidemic and non epidemic years, there was a predominance of females, age 20-59 years and the mild form of the disease, dengue fever. Deaths from dengue in the years 2010 and 2012 in Brazil outnumber deaths from malaria, leishmaniasis, schistosomiasis, leprosy and meningeal infections. The direct costs for hospitalization of dengue in Brazil in the epidemic period was two times higher than in non-epidemic period. The result of dengue DALY was superior to other infectious diseases in developing countries such as malaria and tuberculosis. The DALY reflects part of the impact caused by an old disease, neglected and causing deaths are mostly preventable. Impact studies and disease burden may assist in targeting the professional training of qualified resources for early suspicion of disease, rapid and timely laboratory Diagnoses and allocation of health technologies.
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Tiew, Kok-Chuan. "Dengue virus protease inhibitors." Thesis, Wichita State University, 2011. http://hdl.handle.net/10057/6117.

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Dengue virus (DENV) is a major health threat that affects 2.5 billion people, or 40% of the world’s population. However, there are no approved antiviral drugs or vaccines to treat Dengue infection. This thesis describes the design, synthesis and discovery of a new class of inhibitors of DENV NS3 protease. Structure-activity relationship studies have been carried out in order to delineate the structural elements responsible for the activity of this series of compounds. A lead compound suitable for further development has been identified.
Thesis (M.S.)--Wichita State University, College of Liberal Arts and Sciences, Dept. of Chemistry.
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Cheong, Yoon Ling. "Dengue disease in Malaysia." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät, 2015. http://dx.doi.org/10.18452/17195.

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Der Klimawandel hat weitreichende Folgen auf die Gesundheit der Menschen. Insbesondere Übertragungskrankheiten wie Dengue bekommen global gesehen eine zunehmende Bedeutung. Über die raumzeitliche Verteilung und das Umwelt-Dengue Risiko ist bisher wenig bekannt. Das Hauptziel dieser Dissertation war es daher, die Ätiologie von Dengue in einem hoch endemischen Gebiet besser zu verstehen. Es wurden räumliche Muster des Krankheitsauftretens untersucht, die anschließend in einer Umwelt-Risiko Analyse mit örtlichen Wetterdaten und Landnutzungsinformationen in Zusammenhang gebracht wurden. Zunächst wurde ein raumzeitlicher Ansatz durchgeführt, um herauszufinden, in wie weit Analysen, die verschiedene Aggregationsebenen miteinander kombinieren, zu neuen Erkenntnissen von raumzeitlichen Mustern von Dengue beitragen können. Anschließend wurde ein auf nicht-lineare zeitliche Einflüsse kontrolliertes, Poisson-generalisiertes additives Regressionsmodell genutzt, um herauszufinden, welchen Einfluss Wetterparameter auf die Verbreitung von Dengue haben. Schließlich wurden Boosted regression trees verwendet, um auf nicht-lineare Zusammenhänge und Interaktionen zwischen einzelnen Landnutzungsfaktoren und Dengue zu kontrollieren und um eine Risikokarte zu erstellen. Die Ergebnisse deuten darauf hin, dass mehr als eine geographische Ebene notwendig ist, um Krankheitscluster zu bestätigen. Minimaltemperatur, Regenmenge, und Windgeschwindigkeit waren mit der Verbreitung von Dengue im Untersuchungsgebiet assoziiert. Räumliche Dengue-Muster konnten durch Siedlungen, Wasser, gemischte Landwirtschaftsflächen, offene Flächen und stillgelegte Grünflächen erklärt werden. Dengue-Risiko ist auf der Ergebniskarte des Studiengebietes ersichtlich. Diese Dissertation liefert sowohl wertvolle Informationen für die Gesundheitspolitik in Malaysia als auch wichtige Herangehensweisen für die Entwicklung von Dengue-Kontrollmechanismen in und über die Untersuchungsregion hinaus.
Global changes to our earth system have impacts on human health; specifically vector-borne diseases such as dengue are of epidemiological importance. Dengue is a global disease burden. Little is known about the spatio-temporal distribution and environmental risk association of dengue disease. The main goal of this dissertation was to improve understanding of the etiology of dengue disease in a highly endemic region by focusing on, initially, vulnerability mapping of the disease occurrences and, next, environmental risk assessment between disease clusters and both weather and land use. First, a Spatio-temporal scan statistics approach was used to assess to what extent analyses that combine sub-district and address level data contribute to new insights into spatio-temporal dengue disease patterns to better inform health interventions. Second, a Poisson generalized additive model was used to assess the weather effects on dengue disease accounting for non-linear temporal effects. Third, a Boosted regression trees approach was used to account for nonlinearities and interactions between the land use factors and dengue disease and to generate a risk map. Results suggested that more than one geographical level was needed to confirm the disease clusters. Minimum temperature, rainfall and wind speed, were associated with the dengue cases in the study area. Spatial patterns of dengue cases could be explained by land use types, including human settlements, water bodies, mixed horticulture land, open land and neglected grassland. The predicted risk map depicted dengue risk in the study area. This dissertation provided compelling approaches that are highly valuable for dengue vector control policy advice; applicability is not confined to Malaysia but is transferable to other studies in similar settings.
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Books on the topic "Dengue"

1

Padmanabhan, Radhakrishnan, and Subhash G. Vasudevan, eds. Dengue. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0348-1.

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B, Halstead Scott, ed. Dengue. London: Imperial College Press, 2008.

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B, Halstead Scott, ed. Dengue. London: Imperial College Press, 2008.

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1984-, Bergara Matías, and Watson Ian 1943-, eds. Dengue. Montevideo, Uruguay: Editorial Estuario, 2012.

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Andújar, Daniela. Dengue. Ciudad de Buenos Aires: Daniela Andújar, 2009.

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Gubler, D. J., E. E. Ooi, S. Vasudevan, and J. Farrar, eds. Dengue and dengue hemorrhagic fever. Wallingford: CABI, 2014. http://dx.doi.org/10.1079/9781845939649.0000.

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J, Gubler D., and Kuno Goro, eds. Dengue and dengue hemorrhagic fever. Wallingford, Oxon, UK: CAB International, 1997.

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Thongcharoen, Prasert, ed. Monograph on dengue/dengue haemorrhagic fever. New Delhi: World Health Organization, Regional Office for South-East Asia, 1993.

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Mohana-Borges, Ronaldo, ed. Dengue Virus. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-1879-0.

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Rothman, Alan L., ed. Dengue Virus. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-02215-9.

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Book chapters on the topic "Dengue"

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Zhang, Summer, Kuan Rong Chan, Hwee Cheng Tan, and Eng Eong Ooi. "Dengue Virus Growth, Purification, and Fluorescent Labeling." In Dengue, 3–14. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0348-1_1.

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Manzano, Mark, and Radhakrishnan Padmanabhan. "Targeted Mutagenesis of Dengue Virus Type 2 Replicon RNA by Yeast In Vivo Recombination." In Dengue, 151–60. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0348-1_10.

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Tay, Moon Y. F., Chin Chin Lee, Subhash G. Vasudevan, and Nicole J. Moreland. "Identification of Dengue-Specific Human Antibody Fragments Using Phage Display." In Dengue, 161–73. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0348-1_11.

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Aw, Pauline Poh Kim, Paola Florez de Sessions, Andreas Wilm, Long Truong Hoang, Niranjan Nagarajan, October M. Sessions, and Martin Lloyd Hibberd. "Next-Generation Whole Genome Sequencing of Dengue Virus." In Dengue, 175–95. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0348-1_12.

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Kasprzak, Wojciech K., and Bruce A. Shapiro. "MPGAfold in Dengue Secondary Structure Prediction." In Dengue, 199–224. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0348-1_13.

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Sztuba-Solinska, Joanna, and Stuart F. J. Le Grice. "Insights into Secondary and Tertiary Interactions of Dengue Virus RNA by SHAPE." In Dengue, 225–39. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0348-1_14.

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Choi, Kyung H., and Marc Morais. "Use of Small-Angle X-ray Scattering to Investigate the Structure and Function of Dengue Virus NS3 and NS5." In Dengue, 241–52. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0348-1_15.

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Ward, Alex M., J. Gunaratne, and Mariano A. Garcia-Blanco. "Identification of Dengue RNA Binding Proteins Using RNA Chromatography and Quantitative Mass Spectrometry." In Dengue, 253–70. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0348-1_16.

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Yau, Yin Hoe, and Susana Geifman Shochat. "Analysis of Affinity of Dengue Virus Protein Interaction Using Biacore." In Dengue, 271–84. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0348-1_17.

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Barrows, Nicholas J., Sharon F. Jamison, Shelton S. Bradrick, Caroline Le Sommer, So Young Kim, James Pearson, and Mariano A. Garcia-Blanco. "Functional Genomics Approach for the Identification of Human Host Factors Supporting Dengue Viral Propagation." In Dengue, 285–99. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0348-1_18.

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Conference papers on the topic "Dengue"

1

Carvalho, Thiago, Gabriel Tenório, Marley Vellasco, Karla Figueiredo, and Wouter Caarls. "Comparação de modelos de Machine Learning aplicados a previsão de casos totais de Dengue." In Encontro Nacional de Inteligência Artificial e Computacional. Sociedade Brasileira de Computação - SBC, 2019. http://dx.doi.org/10.5753/eniac.2019.9323.

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A dengue e uma doença endêmica que ocorre principalmente em áreas tropicais, devido à sua transmissão através de mosquitos. Usando mecanismos de pré-processamento e de aprendizado de máquina, esse trabalho objetiva desenvolver um modelo de previsão que estabeleça uma relação existente entre as condicões de uma cidade e a proliferação de epidemia de dengue, como parte da competição 'DengAI - predicting disease spread', fornecida pela plataforma DrivenData. Dentre os modelos implementados, o metodo Ensemble entre o Random Forest e Redes Neurais obtiveram a melhor performance, com melhora de 4,5% em relação ao Benchmark.
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Rufino, Rafael Tavares, Diogo Dantas Moreira, and Francisco Paulo de Freitas Neto. "Dengue 360." In EATIS '18: Euro American Conference on Telematics and Information Systems. New York, NY, USA: ACM, 2018. http://dx.doi.org/10.1145/3293614.3293629.

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Baldi, Alessandro, Eduarda Montiel, Leonardo Mauro Moraes, Amaury Castro Jr., and Ana Kluthcovsky. "2+ Dengue." In I Concurso Integrado de Desenvolvimento de Soluções de Tecnologia e Objetos de Aprendizagem para a Educação. Sociedade Brasileira de Computação - SBC, 2015. http://dx.doi.org/10.5753/cbie.wcbie.2015.186.

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Costa, Diego Vinicius da, Danilo R. Gomes, Christian Santos de Oliveira, Leandro Medeiros da Silva, and Marcus Viníciu Brancos de Souza. "DENGUE ALERTA." In 13th CONTECSI International Conference on Information Systems and Technology Management. TECSI, 2016. http://dx.doi.org/10.5748/9788599693124-13contecsi/rex-1007.

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Fernanda Escocard Santiago, Maria, Maressa Pereira Pessanha, Mila Queiroga Ramos, Liz Stéfanie Morais Viana, and Luiz José de Souza. "Dengue grave, devido trombocitopenia grave e hemoconcentração, aliada a achado ultrassonográfico e derrame plaural." In Semana Científica da Faculdade de Medicina de Campos. Faculdade de Medicina de Campos, 2023. http://dx.doi.org/10.29184/anaisscfmc.v22023p44.

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INTRODUÇÃO A dengue é uma doença infecciosa febril aguda comum em países subtropicais e tropicais, sendo transmitida pela picada da fêmea do mosquito Aedes aegypti. É causada por um vírus pertencente à família Flaviviridae e possui quatro sorotipos diferentes (DENV-1, DENV-2, DENV-3 e DENV-4). Dentre as manifestações clínica, podemos citar como principais a febre aguda, cefaleia frontal, dor retro-orbitária, mialgia, artralgia e prostação. De acordo com os sinais e sintomas apresentado pelo paciente, a dengue pode ser classificada de três formas: dengue, dengue com sinais de alarme e dengue grave. Alterações hemorrágicas como hemoconcentração, leucopenia e plaquetopenia direcionam intervenções terapêuticas e estão relacionadas com a gravidade da doença, fazendo com que parâmetros hematológicos atuem de forma importante no diagnóstico, na evolução e tratamento da dengue. OBJETIVO Relatar caso de dengeu grave, devido trombocitopenia importante e hemoconcentração, aliado a achado ultrassonografico de ascite e derrame pleural. DESCRIÇÃO DE CASO Masculino, 23 anos, deu entrada com história de cefaléia, febre, mialgia, vômitos, prostação intensa, associados a prurido sem exantema de inicio há 04 dias. O paciente recebeu o exame laboratorial e o hemograma completo mostrou uma trombocitopenia grave de 22.000/uL, hemoconcentração 55,1%, TGO 181, TGP 183, PCR 26,0. O teste sorológico complementar mostrou positividade para o antígeno não estrutural 1 da dengue. Sendo assim, o diagnóstico foi feito decisivamente para infecção por dengue e foi solicitado internação hospitalar com intuito de intervenções terapêuticas como terapia de reposição de fluidos padrão, exames laboratoriais e imagem e vigilãncia clínica específica. Durante internação, o paciente evoluiu com dor a palpação superficial do abdômen difusamente e distensão abdominal. Foi realizado ultrassonografia de abdômen total que evidenciou: Líquido em todos os quadrantes, caracterizando uma ascite leve e discrero derrame pleural à direita. Após 5 dias de internação com hidratação vigorosa e tratamento sintomáticos o paciente obteve melhora clínica e laboratorial com hematócrito 41,9%, plaquetas 108.000, TGO 133 e TGP 132. CONCLUSÃO Dessa forma, é extremamente importante o conhecimento, tanto clínico, quanto laboratorial a respeito da dengue para o tratamento e manejo adequado dessa doença prevalente no Brasil.
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Marcolino, Jorge Rubens de Sá, Murilo Silva Nascimento, Ulisses Monteiro da Costa Neto, Eduardo Andrade Lima da Cunha Pedrosa, Maria Natividade de Sá Antunes, Juliana Sá Marcolino, Bruno Rodrigo de Sá Marcolino, and Alírio Caribé Ribeiro Neto. "HEPATITE TRANSINFECCIOSA PELA DENGUE." In II CONGRESSO NORTE-NORDESTE DE SAÚDE PÚBLICA (ONLINE). Editora Omnis Scientia, 2021. http://dx.doi.org/10.47094/iicnnesp.2021/175.

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Ritchie, Scott A. "Changing paradigms of dengue control: A view from a dengue control veteran." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.95097.

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Tsujimoto, Hitoshi. "Differential expression in dengue-infectedAedes albopictusreveals important genes for anti-dengue response." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.113049.

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Amarasinghe, Akarshani, and Viraj B. Wijesuriya. "Drones vs Dengue: A Drone-Based Mosquito Control System for Preventing Dengue." In 2020 RIVF International Conference on Computing and Communication Technologies (RIVF). IEEE, 2020. http://dx.doi.org/10.1109/rivf48685.2020.9140773.

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Syafiq Mustafa, Muhammad Khairul, and Junaida Sulaiman. "Dengue Dashboard for Forecasting the Future Trend of Dengue Cases in Pahang." In 2021 International Conference on Software Engineering & Computer Systems and 4th International Conference on Computational Science and Information Management (ICSECS-ICOCSIM). IEEE, 2021. http://dx.doi.org/10.1109/icsecs-icocsim52883.2021.9733989.

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Reports on the topic "Dengue"

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Wayant, Nicole. Temporal disaggregation of annual dengue cases to monthly dengue cases. Engineer Research and Development Center (U.S.), January 2020. http://dx.doi.org/10.21079/11681/35217.

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Potash, Louis. Safety Testing of Dengue-1 and Dengue-3 Seeds for Human Challenges, Unattenuated. Dengue Virus Type 4. Fort Belvoir, VA: Defense Technical Information Center, July 1988. http://dx.doi.org/10.21236/ada200133.

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Ciapponi, Agustín. Do multi-component community-based interventions improve dengue vector control? SUPPORT, 2017. http://dx.doi.org/10.30846/170507.

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Dengue is an infectious disease transmitted by mosquitoes. Dengue has dramatic negative impacts on health, the environment and the economy, particulary in the tropics. The use of community-based dengue control programmes has increased in the last few decades in order to address this major public health problem.
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Marchette, Nyven J. Safety Testing of Dengue-2 and Dengue-4 Viruses for Use in Human Challenge Experiments. Fort Belvoir, VA: Defense Technical Information Center, April 1988. http://dx.doi.org/10.21236/ada195177.

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Ivy, John M. Development of Dengue Vaccine, Phase 1. Fort Belvoir, VA: Defense Technical Information Center, July 1987. http://dx.doi.org/10.21236/ada260281.

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Ennis, Francis A. Human Immune Response to Dengue Infections. Fort Belvoir, VA: Defense Technical Information Center, July 1990. http://dx.doi.org/10.21236/ada234922.

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Ennis, Francis A. Human Immune Response to Dengue Infections. Fort Belvoir, VA: Defense Technical Information Center, June 1991. http://dx.doi.org/10.21236/ada240717.

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Hod, Rozita. Technology helps tackle surging dengue cases. Edited by Shahirah Hamid. Monash University, February 2024. http://dx.doi.org/10.54377/66b2-6323.

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Rodríguez Reyes, Andrea Jineth, Deccy González Ruge, and Lissethe Carolina Pardo Herrera. Inicio de una nueva fase epidémica de dengue en Colombia. Instituto Nacional de Salud, January 2021. http://dx.doi.org/10.33610/01229907.2021v3n1a1.

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Introducción: en Colombia, el dengue presenta un comportamiento endemoepidémico con brotes cada 3 años y se ha convertido en un problema prioritario en salud pública. Objetivo: describir el comportamiento epidemiológico de dengue en Colombia durante el 2019, para orientar las estrategias de prevención, vigilancia y control. Materiales y métodos: estudio descriptivo de los casos de dengue notificados al Sistema Nacional de Vigilancia en Salud Pública (Sivigila) en Colombia entre la semana epidemiológica 01 a 52 de 2019. Plan de análisis: cálculo de proporciones, tasas, medidas de tendencia central y dispersión. Se calculó los indicadores definidos en el protocolo del evento del Instituto Nacional de Salud. Se identificó los factores relacionados con las muertes por dengue a partir de las unidades de análisis. Resultados: Durante el 2019 se notificaron 124 989 casos de dengue y se confirmaron 122 muertes por dengue. La incidencia a nivel nacional fue de 465,9 casos por 100 000 habitantes, siendo significativamente superior en la población masculina. La mayor proporción de casos se presentó en el grupo de 5 a 14 años. A partir de la semana epidemiológica 08, el evento a nivel nacional presentó una situación de brote sostenido. La región Orinoquía y Amazonía, presentaron las incidencias más altas con 1943,6 casos por 100 000 habitantes y 944,2 casos por 100 000 habitantes, respectivamente. En las muertes por dengue, el principal problema asociado estuvo relacionado con la prestación de los servicios de salud. Conclusión: Colombia inició una nueva fase epidémica de dengue en 2019, con una incidencia superior a la observada en la epidemia de 2016 pero inferior con respecto a los periodos epidémicos 2010 y 2013.
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Potash, Louis. Safety Testing of Dengue-1 and Dengue-3 Seeds for Human Challenges, Unattenuated; Hepatitis A Virus, Strain HM175. Fort Belvoir, VA: Defense Technical Information Center, July 1988. http://dx.doi.org/10.21236/ada201722.

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