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Journal articles on the topic 'Dendritic Scaffolds'

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Author: Grafiati

Published: 4 June 2021

Last updated: 20 February 2023

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1

Wang, Xiuhui, Naoki Kawazoe, and Guoping Chen. "Interaction of Immune Cells and Tumor Cells in Gold Nanorod–Gelatin Composite Porous Scaffolds." Nanomaterials 9, no. 10 (September 24, 2019): 1367. http://dx.doi.org/10.3390/nano9101367.

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Composite porous scaffolds prepared by immobilization of photothermal nano-agents into porous scaffold have been used for both cancer therapy and tissue regeneration. However, it is not clear how the host immune cells and ablated tumor cells interact and stimulate each other in the composite scaffolds. In this research, a gold nanorod-incorporated gelatin composite scaffold with controlled spherical large pores and well interconnected small pores was fabricated by using ice particulates as a porogen. The composite porous scaffold was used for investigating the interaction between dendritic cells and photothermally ablated breast tumor cells. The composite scaffold demonstrated excellent photothermal property and the temperature change value could be adjusted by irradiation time and laser power density. The composite scaffold showed excellent photothermal ablation ability towards breast tumor cells. The photothermally ablated tumor cells induced activation of dendritic cells when immature dendritic cells were co-cultured in the composite scaffold. Consequently, the gold nanorod–incorporated gelatin composite porous scaffold should provide a useful platform for simultaneous photothermal-immune ablation of breast tumor.

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2

Appelhans, Dietmar, Barbara Klajnert-Maculewicz, Anna Janaszewska, Joanna Lazniewska, and Brigitte Voit. "Dendritic glycopolymers based on dendritic polyamine scaffolds: view on their synthetic approaches, characteristics and potential for biomedical applications." Chemical Society Reviews 44, no. 12 (2015): 3968–96. http://dx.doi.org/10.1039/c4cs00339j.

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The potential of dendritic glycopolymers based on dendritic polyamine scaffolds for biomedical applications is presented and compared with that of the structurally related anti-adhesive dendritic glycoconjugates.

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3

Amir, Roey J., Lorenzo Albertazzi, Jenny Willis, Anzar Khan, Taegon Kang, and Craig J. Hawker. "Multifunctional Trackable Dendritic Scaffolds and Delivery Agents." Angewandte Chemie International Edition 50, no. 15 (March 9, 2011): 3425–29. http://dx.doi.org/10.1002/anie.201007427.

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4

Amir, Roey J., Lorenzo Albertazzi, Jenny Willis, Anzar Khan, Taegon Kang, and Craig J. Hawker. "Multifunctional Trackable Dendritic Scaffolds and Delivery Agents." Angewandte Chemie 123, no. 15 (March 9, 2011): 3487–91. http://dx.doi.org/10.1002/ange.201007427.

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5

Molina, Noemi, Ana González, Donato Monopoli, Belinda Mentado, José Becerra, Leonor Santos-Ruiz, Yolanda Vida, and Ezequiel Perez-Inestrosa. "Dendritic Scaffold onto Titanium Implants. A Versatile Strategy Increasing Biocompatibility." Polymers 12, no. 4 (April 1, 2020): 770. http://dx.doi.org/10.3390/polym12040770.

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Osseointegration of metal prosthetic implants is a yet unresolved clinical need that depends on the interplay between the implant surface and bone cells. The lack of a relationship between bone cells and metal has traditionally been solved by coating the former with “organic” ceramics, such as hydroxyapatite. A novel approach is hereby presented, immobilizing covalently dendrimeric structures onto titanium implants. Amide-based amino terminal dendrons were synthetized and coupled to titanium surfaces in a versatile and controlled way. The dendritic moieties provide an excellent scaffold for the covalent immobilization of bioactive molecules, such as extracellular matrix (ECM) protein components or antibiotics. Herein, tripeptide arginine-glycine-aspartic acid (RGD) motifs were used to decorate the dendritic scaffolds and their influence on cell adhesion and proliferation processes was evaluated.

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6

Fernández-Pérez, Julia, Peter W. Madden, Robert Thomas Brady, Peter F. Nowlan, and Mark Ahearne. "The effect of prior long-term recellularization with keratocytes of decellularized porcine corneas implanted in a rabbit anterior lamellar keratoplasty model." PLOS ONE 16, no. 6 (June 1, 2021): e0245406. http://dx.doi.org/10.1371/journal.pone.0245406.

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Decellularized porcine corneal scaffolds are a potential alternative to human cornea for keratoplasty. Although clinical trials have reported promising results, there can be corneal haze or scar tissue. Here, we examined if recellularizing the scaffolds with human keratocytes would result in a better outcome. Scaffolds were prepared that retained little DNA (14.89 ± 5.56 ng/mg) and demonstrated a lack of cytotoxicity by in vitro. The scaffolds were recellularized using human corneal stromal cells and cultured for between 14 in serum-supplemented media followed by a further 14 days in either serum free or serum-supplemented media. All groups showed full-depth cell penetration after 14 days. When serum was present, staining for ALDH3A1 remained weak but after serum-free culture, staining was brighter and the keratocytes adopted a native dendritic morphology with an increase (p < 0.05) of keratocan, decorin, lumican and CD34 gene expression. A rabbit anterior lamellar keratoplasty model was used to compare implanting a 250 μm thick decellularized lenticule against one that had been recellularized with human stromal cells after serum-free culture. In both groups, host rabbit epithelium covered the implants, but transparency was not restored after 3 months. Post-mortem histology showed under the epithelium, a less-compact collagen layer, which appeared to be a regenerating zone with some α-SMA staining, indicating fibrotic cells. In the posterior scaffold, ALDH1A1 staining was present in all the acellular scaffold, but in only one of the recellularized lenticules. Since there was little difference between acellular and cell-seeded scaffolds in our in vivo study, future scaffold development should use acellular controls to determine if cells are necessary.

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7

Leifer, Cynthia A. "Dendritic cells in host response to biologic scaffolds." Seminars in Immunology 29 (February 2017): 41–48. http://dx.doi.org/10.1016/j.smim.2017.01.001.

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8

Sadowski, Lukas P., Patricia E. Edem, John F. Valliant, and Alex Adronov. "Synthesis of Polyester Dendritic Scaffolds for Biomedical Applications." Macromolecular Bioscience 16, no. 10 (July 4, 2016): 1475–84. http://dx.doi.org/10.1002/mabi.201600154.

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9

Piñón-Zárate, Gabriela, Beatriz Hernández-Téllez, Katia Jarquín-Yáñez, Miguel Ángel Herrera-Enríquez, América Eréndira Fuerte-Pérez, Esther Alejandra Valencia-Escamilla, and Andrés Eliú Castell-Rodríguez. "Gelatin/Hyaluronic Acid Scaffold Coupled to CpG and MAGE-A5 as a Treatment against Murine Melanoma." Polymers 14, no. 21 (October 30, 2022): 4608. http://dx.doi.org/10.3390/polym14214608.

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The half-time of cells and molecules used in immunotherapy is limited. Scaffolds-based immunotherapy against cancer may increase the half-life of the molecules and also support the migration and activation of leukocytes in situ. For this purpose, the use of gelatin (Ge)/hyaluronic acid (HA) scaffolds coupled to CpG and the tumor antigen MAGE-A5 is proposed. Ge and HA are components of the extracellular matrix that stimulate cell adhesion and activation of leucocytes; CpG can promote dendritic cell maturation, and MAGE-A5 a specific antitumor response. C57BL/6 mice were treated with Ge/HA/scaffolds coupled to MAGE-A5 and/or CpG and then challenged with the B16-F10 melanoma cell line. Survival, tumor growth rate and the immune response induced by the scaffolds were analyzed. Ge/HA/CpG and Ge/HA/MAGE-A5 mediated dendritic cell maturation and macrophage activation, increased survival, and decreased the tumor growth rate and a tumor parenchyma with abundant cell death areas and abundant tumor cells with melanin granules. Only the scaffolds coupled to MAGE-A5 induced the activation of CD8 T cells. In conclusion, Ge/HA scaffolds coupled to CpG or MAGE-A5, but not the mixture, can induce a successful immune response capable of promoting tumor cell clearance and increased survival.

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10

Sreeperumbuduru, R. S., Z. M. Abid, K. M. Claunch, H. H. Chen, S. M. McGillivray, and E. E. Simanek. "Synthesis and antimicrobial activity of triazine dendrimers with DABCO groups." RSC Advances 6, no. 11 (2016): 8806–10. http://dx.doi.org/10.1039/c5ra10388f.

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11

Li, Xiao, Caiping Yan, Dengyuan Wang, Hong Lu, and Zhidao Xia. "Fabrication of Micro-Nano Bioactive Glass Scaffold Incorporated with Siglec-15 for Bone Repair and Postoperative Treatment of Osteosarcoma." Science of Advanced Materials 13, no. 8 (August 1, 2021): 1445–51. http://dx.doi.org/10.1166/sam.2021.4000.

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This study aimed to fabricate micro-nano bioactive glass (MNBG) scaffolds loaded with chemotherapeutics and siglec-15 monoclonal antibody with bone repair capability and high-active drug loading capability for postoperative treatment of osteosarcoma. Bioactive glass (BG) particles were incorporated with siglec-15 mAb and gemcitabine through mesopores and calcium ions on the surface. Dendritic cells (DCs) were treated with siglec-loaded BGs and gemcitabine. RT-qPCR analysis was conducted to detect DJ-1 and PTEN mRNA levels, CCK-8 technology to detect cell activity, and flow cytometry to detect cell apoptosis. Rats were administrated with siglec-15-MNBG composite scaffolds with/without gemcitabine. 3D printing was used to determine adhesion strength of each group. Administration of MNBG scaffold decreased the expression of PTEN and up-regulated expression of DJ-1 when inducing cell apoptosis. Combined treatment with gemcitabine augmented adhesion of material and enhanced phosphorylation activity of p-AKT, mitigating the inhibitory effect of scaffold loaded with siglec-15 on p-AKT protein expression. Collectively, MNBG scaffold loaded with siglec-15 might promote bone regeneration and incorporate with chemotherapeutic drugs to suppress tumor development and promote apoptosis through PTEN/PI3 K pathway. These findings provide a novel insight into postoperative treatment of osteosarcoma and help development of tumor immunotherapy/bone repair integrated materials.

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12

Kim, Hye Sung, Tzu-Chieh Ho, Moshe J. Willner, Michael W. Becker, Hae-Won Kim, and Kam W. Leong. "Dendritic cell-mimicking scaffolds for ex vivo T cell expansion." Bioactive Materials 21 (March 2023): 241–52. http://dx.doi.org/10.1016/j.bioactmat.2022.08.015.

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13

Shiao, Tze, Rabindra Rej, Mariécka Rose, Giovanni Pavan, and René Roy. "Synthesis of Dense and Chiral Dendritic Polyols Using Glyconanosynthon Scaffolds." Molecules 21, no. 4 (April 4, 2016): 448. http://dx.doi.org/10.3390/molecules21040448.

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14

García Velázquez, Daniel, Rafael Luque, and Ángel Gutiérrez Ravelo. "Microwave-Assisted Synthesis and Properties of Novel Hexaazatrinaphthylene Dendritic Scaffolds." Molecules 25, no. 21 (October 30, 2020): 5038. http://dx.doi.org/10.3390/molecules25215038.

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A novel family of water-soluble π-conjugated hexaazatrinaphthylenes-based dendritic architectures constructed by hexaketocyclohexane and 1,2,4,5-benzenetetramine units is developed in a microwave-assisted organic synthesis (MAOS) approach. The structures and purity of these compounds are verified by 1H and 13C-NMR, MALDI-TOF MS, UV-vis, elemental analysis, DSC, AFM, STM and cyclic voltammetry.

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15

Saez, Isabel M., and John W. Goodby. "Segregated liquid crystalline dendritic supermolecules — multipedes based on pentaerythritol scaffolds." J. Mater. Chem. 13, no. 11 (2003): 2727–39. http://dx.doi.org/10.1039/b303654e.

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16

Du, Xu-Sheng, Cui-Feng Zhou, and Yiu-Wing Mai. "Facile Synthesis of Hierarchical Polyaniline Nanostructures with Dendritic Nanofibers as Scaffolds." Journal of Physical Chemistry C 112, no. 50 (November 18, 2008): 19836–40. http://dx.doi.org/10.1021/jp8069404.

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17

Douloudi, Marilina, Eleni Nikoli, Theodora Katsika, Michalis Vardavoulias, and Michael Arkas. "Dendritic Polymers as Promising Additives for the Manufacturing of Hybrid Organoceramic Nanocomposites with Ameliorated Properties Suitable for an Extensive Diversity of Applications." Nanomaterials 11, no. 1 (December 24, 2020): 19. http://dx.doi.org/10.3390/nano11010019.

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As the field of nanoscience is rapidly evolving, interest in novel, upgraded nanomaterials with combinatory features is also inevitably increasing. Hybrid composites, offer simple, budget-conscious and environmental-friendly solutions that can cater multiple needs at the same time and be applicable in many nanotechnology-related and interdisciplinary studies. The physicochemical idiocrasies of dendritic polymers have inspired their implementation as sorbents, active ingredient carriers and templates for complex composites. Ceramics are distinguished for their mechanical superiority and absorption potential that render them ideal substrates for separation and catalysis technologies. The integration of dendritic compounds to these inorganic hosts can be achieved through chemical attachment of the organic moiety onto functionalized surfaces, impregnation and absorption inside the pores, conventional sol-gel reactions or via biomimetic mediation of dendritic matrices, inducing the formation of usually spherical hybrid nanoparticles. Alternatively, dendritic polymers can propagate from ceramic scaffolds. All these variants are covered in detail. Optimization techniques as well as established and prospected applications are also presented.

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18

Govender, Preshendren, Nathan C. Antonels, Johan Mattsson, Anna K. Renfrew, Paul J. Dyson, John R. Moss, Bruno Therrien, and Gregory S. Smith. "Anticancer activity of multinuclear arene ruthenium complexes coordinated to dendritic polypyridyl scaffolds." Journal of Organometallic Chemistry 694, no. 21 (October 2009): 3470–76. http://dx.doi.org/10.1016/j.jorganchem.2009.06.028.

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19

Chen, Ruying, Hongyan Ma, Lei Zhang, and James D. Bryers. "Precision‐porous templated scaffolds of varying pore size drive dendritic cell activation." Biotechnology and Bioengineering 115, no. 4 (January 22, 2018): 1086–95. http://dx.doi.org/10.1002/bit.26532.

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20

Kivala, Milan, and François Diederich. "Conjugation and optoelectronic properties of acetylenic scaffolds and charge-transfer chromophores." Pure and Applied Chemistry 80, no. 3 (January 1, 2008): 411–27. http://dx.doi.org/10.1351/pac200880030411.

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Our group started a research program in acetylene chemistry in 1987; since then, an intense research effort led to a fascinating journey into acetylenic scaffolding, aimed at exploring conjugative and optoelectronic properties of acetylenic chromophores. This journey included the generation of a unique molecular construction kit for acetylenic scaffolding, consisting of (E)-1,2-diethynylethenes [DEEs, (E)-hex-3-ene-1,5-diynes], tetraethynylethenes (TEEs, 3,4-diethynylhex-3-ene-1,5-diynes), chiral 1,3-diethynylallenes (DEAs, hepta-3,4-diene-1,6-diynes), 1,4-di and 1,1,4,4-tetraethynylbutatrienes, chiral trialkynylmethanes, and 1,1,2,2-tetraethynylethanes. These building modules were subsequently applied to the synthesis of carbon-rich architectures extending into one, two, and three dimensions. They include multinanometer-long monodisperse oligomers as models for infinite acetylenic polymers, molecular switches, perethynylated dehydroannulenes, expanded radialenes, and radiaannulenes, and an octamethoxy-substituted expanded cubane with a central C56 core. Donor-substituted cyanoethynylethenes (CEEs) and 1,1,4,4-tetracyanobuta-1,3-dienes (TCBDs) were introduced as new push-pull chromophores featuring intense intramolecular charge-transfer (CT) interactions. Dendritic multivalent CT chromophores were constructed using atom-economic, "click"-like reactions, and these systems were shown to behave as "molecular batteries", featuring exceptional electron uptake and storage capacity. The research finally led to the development of an unprecedented cascade reaction for the preparation of dendritic and oligomeric donor-acceptor (D-A) molecules. New [AB]-type oligomers become accessible in domino reactions involving repetitive sequences of [2+2] cycloadditions of tetracyanoethylene (TCNE) and tetrathiafulvalene (TTF) to polyynes, followed by retro-electrocyclizations.

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21

Orbach, Sophia, Michael D. Brooks, Grace G. Bushnell, Max S. Wicha, Jacqueline S. Jeruss, and Lonnie D. Shea. "4026 Dissecting the role of microenvironment heterogeneity on metastatic tumor cell phenotype at an engineered metastatic niche." Journal of Clinical and Translational Science 4, s1 (June 2020): 5–6. http://dx.doi.org/10.1017/cts.2020.62.

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OBJECTIVES/GOALS: Breast cancer metastases are stochastic and difficult to detect. Therapy is often ineffective due to phenotypic changes of tumor cells at these sites. We engineered a synthetic metastatic niche to study the role of phenotypic transitions in the microenvironment on tumor cell phenotype. METHODS/STUDY POPULATION: The engineered metastatic niche is composed of a porous polycaprolactone scaffold implanted subcutaneously in Balb/c mice. The mice received an orthotopic inoculation of 4T1 cells (murine triple negative breast cancer) in the fourth right mammary fat pad and the disease was allowed to progress for 7-21 days (pre-metastatic to overt metastatic disease). The scaffolds and lungs (native metastatic site) were explanted and analyzed by single cell RNA-seq via Drop-seq. Cell phenotypes were identified and tracked over time with the Seurat and Monocle3 pipelines. Assessment of the impact of these cell populations on tumor cell phenotype was conducted through Transwell co-cultures. RESULTS/ANTICIPATED RESULTS: Healthy scaffolds are primarily composed of macrophages, dendritic cells, and fibroblasts – consistent with a foreign body response. Despite differences in the lung and scaffold prior to tumor inoculation, both tissues were marked by >5-fold increase in neutrophils/MDSCs. Additionally, 79% of genes at the scaffold that significantly changed over time were also identified in the lung, indicating key similarities in niche maturation. However, many immune cells at the scaffold had distinct phenotypes, with pro-inflammatory/cytotoxic characteristics. These changes clearly impacted tumor cell phenotype, as cells from the scaffold increased tumor cell migration and apoptosis in vitro. DISCUSSION/SIGNIFICANCE OF IMPACT: Early phenotypic changes at the engineered metastatic niche can identify signs of metastasis prior to colonization of tumor cells. Furthermore, dynamics of immune and stromal cells change throughout niche maturation, influencing tumor cell phenotype and may suggest targeted therapies. CONFLICT OF INTEREST DESCRIPTION: Lonnie Shea, Jacqueline Jeruss, and Grace Bushnell are named inventors on patents or patent applications.

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22

Wigerius, Michael, Dylan Quinn, Antonios Diab, Leanne Clattenburg, Annette Kolar, Jiansong Qi, Stefan R. Krueger, and James P. Fawcett. "The polarity protein Angiomotin p130 controls dendritic spine maturation." Journal of Cell Biology 217, no. 2 (January 9, 2018): 715–30. http://dx.doi.org/10.1083/jcb.201705184.

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The actin cytoskeleton is essential for the structural changes in dendritic spines that lead to the formation of new synapses. Although the molecular mechanisms underlying spine formation are well characterized, the events that drive spine maturation during development are largely unknown. In this study, we demonstrate that Angiomotin (AMOT-130) is necessary for spine stabilization. AMOT-130 is enriched in mature dendritic spines and functions to stabilize the actin cytoskeleton by coupling F-actin to postsynaptic protein scaffolds. These functions of AMOT are transiently restricted during postnatal development by phosphorylation imposed by the kinase Lats1. Our study proposes that AMOT-130 is essential for normal spine morphogenesis and identifies Lats1 as an upstream regulator in this process. Moreover, our findings may link AMOT-130 loss and the related spine defects to neurological disorders.

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23

Carlmark, Anna, Eva Malmström, and Michael Malkoch. "Dendritic architectures based on bis-MPA: functional polymeric scaffolds for application-driven research." Chemical Society Reviews 42, no. 13 (2013): 5858. http://dx.doi.org/10.1039/c3cs60101c.

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24

Fomina, Nadezda, Cathryn L. McFearin, and Adah Almutairi. "Increasing materials' response to two-photon NIR light via self-immolative dendritic scaffolds." Chemical Communications 48, no. 73 (2012): 9138. http://dx.doi.org/10.1039/c2cc00072e.

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25

Antonels, Nathan C., John R. Moss, and Gregory S. Smith. "Hydroformylation activity of multinuclear rhodium complexes coordinated to dendritic iminopyridyl and iminophosphine scaffolds." Journal of Organometallic Chemistry 696, no. 10 (May 2011): 2003–7. http://dx.doi.org/10.1016/j.jorganchem.2010.10.048.

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26

Shirao, Tomoaki, and Yuko Sekino. "Clustering and anchoring mechanisms of molecular constituents of postsynaptic scaffolds in dendritic spines." Neuroscience Research 40, no. 1 (May 2001): 1–7. http://dx.doi.org/10.1016/s0168-0102(01)00209-7.

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27

Appelhans, Dietmar, Barbara Klajnert-Maculewicz, Anna Janaszewska, Joanna Lazniewska, and Brigitte Voit. "ChemInform Abstract: Dendritic Glycopolymers Based on Dendritic Polyamine Scaffolds: View on Their Synthetic Approaches, Characteristics and Potential for Biomedical Applications." ChemInform 46, no. 32 (July 24, 2015): no. http://dx.doi.org/10.1002/chin.201532279.

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28

Rosas-García, Jorge, Lucero A. Ramón-Luing, Karen Bobadilla, Marco Antonio Meraz-Ríos, Edgar E. Sevilla-Reyes, and Teresa Santos-Mendoza. "Distinct Transcriptional Profile of PDZ Genes after Activation of Human Macrophages and Dendritic Cells." International Journal of Molecular Sciences 23, no. 13 (June 24, 2022): 7010. http://dx.doi.org/10.3390/ijms23137010.

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The PDZ (PSD95, Dlg and ZO-1) genes encode proteins that primarily function as scaffolds of diverse signaling pathways. To date, 153 PDZ genes have been identified in the human genome, most of which have multiple protein isoforms widely studied in epithelial and neural cells. However, their expression and function in immune cells have been poorly studied. Herein, we aimed to assess the transcriptional profiles of 83 PDZ genes in human macrophages (Mɸ) and dendritic cells (DCs) and changes in their relative expression during cell PRR stimulation. Significantly distinct PDZ gene transcriptional profiles were identified under different stimulation conditions. Furthermore, a distinct PDZ gene transcriptional signature was found in Mɸ and DCs under the same phagocytic stimuli. Notably, more than 40 PDZ genes had significant changes in expression, with potentially relevant functions in antigen-presenting cells (APCs). Given that several PDZ proteins are targeted by viral products, our results support that many of these proteins might be viral targets in APCs as part of evasion mechanisms. Our results suggest a distinct requirement for PDZ scaffolds in Mɸ and DCs signaling pathways activation. More assessments on the functions of PDZ proteins in APCs and their role in immune evasion mechanisms are needed.

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Pinner, Sophie, and Shannon Turley. "Podoplanin-rich stromal networks induce dendritic cell motility via activation of CLEC-2 (102.21)." Journal of Immunology 186, no. 1_Supplement (April 1, 2011): 102.21. http://dx.doi.org/10.4049/jimmunol.186.supp.102.21.

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Abstract Cell motility is crucial for leukocytes to traffic between tissues and to interact with one another and their microenvironment. Stromal cells provide 3-dimensional scaffolds and molecular cues that coordinate leukocyte migration and compartmentalization within secondary lymphoid organs. Dendritic cells (DCs) are antigen presenting cells whose migration via stromal networks is critical for the induction of both immunogenic and tolerogenic T cell responses. DCs migrate in an amoeboid, integrin-independent manner, utilizing the chemokine receptor CCR7 to navigate their way to lymph nodes (LNs). However the molecules utilised by DCs and other leukocytes to interact with stroma are still largely unknown. Here we describe a novel motility mechanism driven by the glycoprotein podoplanin (gp38) that induces motility of DCs that express the C-type lectin-like receptor 2 (CLEC-2, CLEC-1b). Podoplanin-mediated activation of CLEC-2 promotes dynamic, actin-rich protrusions, and migration along stroma. The podoplanin-CLEC-2 interaction endows DCs with the capacity to crawl along stromal cell scaffolds of secondary lymphoid organs and to find and properly activate T cells. Our results illuminate a novel mechanism of leukocyte migration pertaining to multiple steps in the adaptive immune response which we propose functions in concert with chemokine gradients to ensure efficient, directional leukocyte trafficking.

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Sallam, Lamyaa M., Tze Chieh Shiao, Celia Sehad, Abdelkrim Azzouz, and René Roy. "Accelerated Synthesis of Surface Functionalized Mannosylated Dendrimers Built on Cyclotriphosphazene Core." MRS Advances 4, no. 59-60 (2019): 3187–98. http://dx.doi.org/10.1557/adv.2019.375.

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ABSTRACTThe syntheses of five propargylated dendrimer scaffolds ranging from 2, 3, 4, 6, and 12 surface groups are described together with a 2-azidoethyl α-D-mannopyranoside. The former is appended to the core structure using highly efficient copper-catalysed azide-alkyne cycloaddition (CuAAC) (“click reaction”) to provide glycodendrimers in an accelerated approach. Two of the core structures are based on cyclotrisphosphazene, thus expanding the scope of the “onion-peel” strategy to build dendritic architectures with a large number of surface groups at the G1 generation only.

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31

Aldinucci, Alessandra, Antonio Turco, Tiziana Biagioli, Francesca Maria Toma, Daniele Bani, Daniele Guasti, Cinzia Manuelli, et al. "Carbon Nanotube Scaffolds Instruct Human Dendritic Cells: Modulating Immune Responses by Contacts at the Nanoscale." Nano Letters 13, no. 12 (November 15, 2013): 6098–105. http://dx.doi.org/10.1021/nl403396e.

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32

Nguyen, Thanh Loc, Yue Yin, Youngjin Choi, Ji Hoon Jeong, and Jaeyun Kim. "Enhanced Cancer DNA Vaccine via Direct Transfection to Host Dendritic Cells Recruited in Injectable Scaffolds." ACS Nano 14, no. 9 (August 18, 2020): 11623–36. http://dx.doi.org/10.1021/acsnano.0c04188.

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33

Pawlica, Dariusz, Marek Marszałek, Grzegorz Mynarczuk, Lesław Sieroń, and Julita Eilmes. "New unsymmetrical Schiff base Ni(ii) complexes as scaffolds for dendritic and amino acid superstructures." New J. Chem. 28, no. 12 (2004): 1615–21. http://dx.doi.org/10.1039/b409298h.

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34

Yang, Yanzhu, Sanyuan Shi, Qian Ding, Jian Chen, Jinliang Peng, and Yuhong Xu. "Multiwalled carbon nanotube-modified poly(d,l-lactide-co-glycolide) scaffolds for dendritic cell load." Journal of Biomedical Materials Research Part A 103, no. 3 (June 16, 2014): 1045–52. http://dx.doi.org/10.1002/jbm.a.35255.

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35

Carlmark, Anna, Eva Malmstroem, and Michael Malkoch. "ChemInform Abstract: Dendritic Architectures Based on Bis-MPA: Functional Polymeric Scaffolds for Application-Driven Research." ChemInform 44, no. 37 (August 22, 2013): no. http://dx.doi.org/10.1002/chin.201337235.

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36

Ordanini, Stefania, Giulio Goti, and Anna Bernardi. "From optimized monovalent ligands to size-controlled dendrimers: an efficient strategy towards high-activity DC-SIGN antagonists." Canadian Journal of Chemistry 95, no. 9 (September 2017): 881–90. http://dx.doi.org/10.1139/cjc-2017-0138.

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This short review describes our work on the development of dendrimeric antagonists of DC-SIGN, a dendritic cells (DCs) receptor recognizing highly mannosylated structures and primarily involved in the recognition of viruses such as HIV. The structure of pseudo-di-mannoside and pseudo-tri-mannoside compounds was first finely modified to obtain DC-SIGN ligands that were more stable and selective than mannose. Their DC-SIGN affinity differences were amplified once presented on multivalent dendrimer-like scaffolds, including poly-alkyne terminated and phenylene-ethynylene rod-like ones. Libraries of mannosylated dendrimers were synthesized, improving their stability and maximizing their monodispersity. The effect of the dendrimers valency, structure, and size on DC-SIGN affinity and antiviral potency was investigated. Both the valency and the topology of the architectures were revealed as key parameters for activity optimization, together with the intrinsic affinity of the monovalent ligand. The stability, rigidity, and length of the scaffolds were also tuned. The design of geometrically adapted scaffolds afforded one of the most potent inhibitors of DC-SIGN mediated HIV infections to date. This monodispersed, not cytotoxic, and highly active compound was also tested with DCs; its internalization into endolysosomal compartments and its ability to induce the overexpression of signaling molecules makes it a good precursor to produce pathogen-entry inhibitors with immunomodulant properties.

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Morisaki, Takashi, Takafumi Morisaki, Makoto Kubo, Shinji Morisaki, Yusuke Nakamura, and Hideya Onishi. "Lymph Nodes as Anti-Tumor Immunotherapeutic Tools: Intranodal-Tumor-Specific Antigen-Pulsed Dendritic Cell Vaccine Immunotherapy." Cancers 14, no. 10 (May 15, 2022): 2438. http://dx.doi.org/10.3390/cancers14102438.

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Hundreds of lymph nodes (LNs) are scattered throughout the body. Although each LN is small, it represents a complete immune organ that contains almost all types of immunocompetent and stromal cells functioning as scaffolds. In this review, we highlight the importance of LNs in cancer immunotherapy. First, we review recent reports on structural and functional properties of LNs as sites for antitumor immunity and discuss their therapeutic utility in tumor immunotherapy. Second, we discuss the rationale and background of ultrasound (US)-guided intranodal injection methods. In addition, we review intranodal administration therapy of tumor-specific-antigen-pulsed matured dendritic cells (DCs), including neoantigen-pulsed vaccines.

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Öberg, Kim, Jarmo Ropponen, Jonathan Kelly, Peter Löwenhielm, Mattias Berglin, and Michael Malkoch. "Templating Gold Surfaces with Function: A Self-Assembled Dendritic Monolayer Methodology Based on Monodisperse Polyester Scaffolds." Langmuir 29, no. 1 (December 19, 2012): 456–65. http://dx.doi.org/10.1021/la3041314.

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Laboria, Noemi, Alex Fragoso, Wolfgang Kemmner, Daniel Latta, Olle Nilsson, Mary Luz Botero, Klaus Drese, and Ciara K. O’Sullivan. "Amperometric Immunosensor for Carcinoembryonic Antigen in Colon Cancer Samples Based on Monolayers of Dendritic Bipodal Scaffolds." Analytical Chemistry 82, no. 5 (March 2010): 1712–19. http://dx.doi.org/10.1021/ac902162e.

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Nishimura, Shunichi, Tomoyuki Tajima, Tatsuki Hasegawa, Tomoaki Tanaka, Yutaka Takaguchi, Yuya Oaki, and Hiroaki Imai. "Synthesis of a poly(amidoamine) dendrimer having a 1,10-bis(decyloxy)decane core and its use in fabrication of carbon nanotube/calcium carbonate hybrids through biomimetic mineralization." Canadian Journal of Chemistry 95, no. 9 (September 2017): 935–41. http://dx.doi.org/10.1139/cjc-2017-0022.

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A new dendritic dispersant of carbon nanotubes (CNTs) was synthesized and applied for the noncovalent functionalization of single-walled carbon nanotubes (SWCNTs) and multi-walled carbon nanotubes (MWCNTs). The 1,10-bis(decyloxy)decane core of the poly(amidoamine) dendrimer strongly adhered to the sidewalls of CNTs to form CNT/dendrimer supramolecular nanocomposites having many carboxyl groups (–COOH) on the surface. Then, crystallization of calcium carbonate (CaCO3) by the CO2 diffusion technique in aqueous environments using the CNT/dendrimer supramolecular nanocomposites as scaffolds afforded monodisperse spherical CNT/CaCO3 nanohybrids consisting of CNTs and calcite nanocrystals. The morphologies of the SWCNT/CaCO3 hybrids and MWCNT/CaCO3 hybrids were almost the same.

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Pinner, Sophie, Diego Mourao-Sa, and Shannon Turley. "Podoplanin interactions with CLEC-2 regulate dendritic cell migration (44.4)." Journal of Immunology 184, no. 1_Supplement (April 1, 2010): 44.4. http://dx.doi.org/10.4049/jimmunol.184.supp.44.4.

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Abstract The migration of dendritic cells (DCs) from peripheral tissues to lymph nodes (LNs) is critical for the generation of protective immune responses and maintenance of self-tolerance. In our studies of DC trafficking we observed that migratory DCs, arriving in LNs from inflamed skin, exhibited elevated surface levels of the C-type lectin, CLEC-2. CLEC-2 activation in DCs was found to induce actin polymerization and increased protrusive activity, directly linking CLEC-2 to altered cytoskeletal dynamics and DC motility. CLEC-2 binds to podoplanin, a 38kDa surface glycoprotein required for correct formation of lymphatic vessels. Interestingly, podoplanin is normally expressed by both lymphatic endothelium (LECs) and fibroblastic reticular cells (FRCs); two stromal cell subtypes that directly interact with migratory DCs en route to the LN paracortex. Using a 3D in vitro culture system combined with time-lapse confocal microscopy we found that FRCs promote migration of DCs in a CCR7-independent manner. Podoplanin localizes to sites of contact between FRCs and DCs, and is required for DC migration along FRC scaffolds. Furthermore, hydrodynamic intradermal injection of podoplanin siRNA, used to silence podoplanin expression by LECs and FRCs, significantly impaired migration of DCs from skin to draining LNs. Our data illuminate important new features of DC-stromal cell interactions and reveal a critical role for podoplanin and its receptor CLEC-2 in regulating DC trafficking to LNs.

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Si, Youhui, Qiaomu Tian, Fan Zhao, Sean H. Kelly, Lucas S. Shores, Daniel F. Camacho, Anne I. Sperling, Michael S. Andrade, Joel H. Collier, and Anita S. Chong. "Adjuvant-free nanofiber vaccine induces in situ lung dendritic cell activation and TH17 responses." Science Advances 6, no. 32 (August 2020): eaba0995. http://dx.doi.org/10.1126/sciadv.aba0995.

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The current paradigm that subunit vaccines require adjuvants to optimally activate innate immunity implies that increased vaccine reactogenicity will invariably be linked to improved immunogenicity. Countering this paradigm, nanoparticulate vaccines have been reported to act as delivery systems for vaccine antigens and induce immunity without the need for exogenous adjuvants or local inflammation; however, the mechanisms underlying the immunogenicity of nanoparticle vaccines are incompletely identified. Here, we show that antigens displayed on self-assembling nanofiber scaffolds and delivered intranasally are presented by CD103+ and CD11b+ lung dendritic cells that up-regulate CD80 and migrate into the draining lymph node (LN). This was accompanied by a nearly exclusive priming and accumulation of antigen-specific TH17 cells occurring independently in both LN and lung. Thus, self-assembling peptide nanofiber vaccines may represent a novel, needle- and adjuvant-free means of eliciting protective immunity against fungal and bacterial infections at skin and mucosal barrier surfaces.

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Das, Eva C., Sameer Dhawan, Jisha Babu, PR Anil Kumar, Thrikkovil Variathu Kumary, V. Haridas, and Manoj Komath. "Self‐assembling polymeric dendritic peptide as functional osteogenic matrix for periodontal regeneration scaffolds—an in vitro study." Journal of Periodontal Research 54, no. 5 (March 20, 2019): 468–80. http://dx.doi.org/10.1111/jre.12647.

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Hed, Yvonne, Kim Öberg, Sandra Berg, Axel Nordberg, Hans von Holst, and Michael Malkoch. "Multipurpose heterofunctional dendritic scaffolds as crosslinkers towards functional soft hydrogels and implant adhesives in bone fracture applications." Journal of Materials Chemistry B 1, no. 44 (2013): 6015. http://dx.doi.org/10.1039/c3tb21061h.

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Martín-Rapún, Rafael, Miguel Cano, Mark McKenna, José Luis Serrano, and Mercedes Marcos. "Side-On Nematic Liquid Crystal Dendrimers Based on PAMAM and PPI as Dendritic Scaffolds: Synthesis and Characterization." Macromolecular Chemistry and Physics 216, no. 9 (March 19, 2015): 950–57. http://dx.doi.org/10.1002/macp.201400598.

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Lämmermann, Tim, Jörg Renkawitz, Xunwei Wu, Karin Hirsch, Cord Brakebusch, and Michael Sixt. "Cdc42-dependent leading edge coordination is essential for interstitial dendritic cell migration." Blood 113, no. 23 (June 4, 2009): 5703–10. http://dx.doi.org/10.1182/blood-2008-11-191882.

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Abstract Mature dendritic cells (DCs) moving from the skin to the lymph node are a prototypic example of rapidly migrating amoeboid leukocytes. Interstitial DC migration is directionally guided by chemokines, but independent of specific adhesive interactions with the tissue as well as pericellular proteolysis. Instead, the protrusive flow of the actin cytoskeleton directly drives a basal mode of locomotion that is occasionally supported by actomyosin contractions at the trailing edge to propel the cell's rigid nucleus. We here delete the small GTPase Cdc42 in DCs and find that actin flow and actomyosin contraction are still initiated in response to chemotactic cues. Accordingly, the cells are able to polarize and form protrusions. However, in the absence of Cdc42 the protrusions are temporally and spatially dysregulated, which leads to impaired leading edge coordination. Although this defect still allows the cells to move on 2-dimensional surfaces, their in vivo motility is completely abrogated. We show that this difference is entirely caused by the geometric complexity of the environment, as multiple competing protrusions lead to instantaneous entanglement within 3-dimensional extracellular matrix scaffolds. This demonstrates that the decisive factor for migrating DCs is not specific interaction with the extracellular environment, but adequate coordination of cytoskeletal flow.

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Dai, Jingtao, Felix Umrath, Siegmar Reinert, and Dorothea Alexander. "Jaw Periosteal Cells Seeded in Beta-Tricalcium Phosphate Inhibit Dendritic Cell Maturation." Biomolecules 10, no. 6 (June 10, 2020): 887. http://dx.doi.org/10.3390/biom10060887.

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Mesenchymal stem cells (MSCs) have gained attraction not only in the field of regenerative medicine but also in the field of autoimmune disease therapies or organ transplantation due to their immunoregulatory and/or immunosuppressive features. Dendritic cells (DCs) play a crucial role in initiating and regulating immune reactions by promoting antigen-specific T cell activation. In this study, we investigated the effect of human jaw periosteal progenitor cells (JPCs) seeded in beta-tricalcium phosphate (β-TCP) scaffolds on monocyte-derived DC differentiation. Significantly lower numbers of differentiated DCs were observed in the presence of normal (Co) and osteogenically induced (Ob) JPCs-seeded β-TCP constructs. Gene expression analysis revealed significantly lower interleukin-12 subunit p35 (IL-12p35) and interleukin-12 receptor beta 2 (IL-12Rβ2) and pro-inflammatory cytokine interferon-gamma (IFN-γ) levels in DCs under Ob conditions, while interleukin-8 (IL-8) gene levels were significantly increased. Furthermore, in the presence of JPCs-seeded β-TCP constructs, interleukin-10 (IL-10) gene expression was significantly induced in DCs, particularly under Ob conditions. Analysis of DC protein levels shows that granulocyte-colony stimulating factor (G-CSF) was significantly upregulated in coculture groups. Our results indicate that undifferentiated and osteogenically induced JPCs-seeded β-TCP constructs have an overall inhibitory effect on monocyte-derived DC maturation.

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Zhu, Kaiping, Pan Xue, Guanjian Cheng, Menglei Wang, Han Wang, Chao Bao, Kai Zhang, et al. "Thermo-managing and flame-retardant scaffolds suppressing dendritic growth and polysulfide shuttling toward high-safety lithium–sulfur batteries." Energy Storage Materials 43 (December 2021): 130–42. http://dx.doi.org/10.1016/j.ensm.2021.08.031.

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Lei, Chang, Yuxue Cao, Sepanta Hosseinpour, Fang Gao, Jingyu Liu, Jianye Fu, Reuben Staples, Saso Ivanovski, and Chun Xu. "Hierarchical dual-porous hydroxyapatite doped dendritic mesoporous silica nanoparticles based scaffolds promote osteogenesis in vitro and in vivo." Nano Research 14, no. 3 (October 23, 2020): 770–77. http://dx.doi.org/10.1007/s12274-020-3112-2.

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Kirihara, Soshu. "Stereolithographic Additive Manufacturing of Bulky Ceramic Components with Functionally Geometric Micropattern." Additional Conferences (Device Packaging, HiTEC, HiTEN, and CICMT) 2016, CICMT (May 1, 2016): 000001–5. http://dx.doi.org/10.4071/2016cicmt-ta11.

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Abstract In a stereolithographic additive manufacturing (AM), two dimensional (2D) cross sectional patterns were created through photo polymerization by ultraviolet laser drawing on spread resin paste including ceramic nanoparticles, and three dimensional (3D) composite models were sterically printed by layer lamination through chemical bonding. An automatic collimeter was equipped with the laser scanner to adjust beam diameter. Fine or coarse beams could realize high resolution or wide area drawings, respectively. Metal and ceramic bulky components including dendritic networks were geometrically built by using stereolithographic AM. Geometric patterns with periodic, self-similar, graded and fluctuated arrangements were created by computer aided design, manufacture and evaluation (CAD/CAM/CAE) for effective modulations of energy and material flows through dielectric lattices in photonic crystals, porous electrodes in fuel cells and biological scaffolds in artificial bones.

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