Relevant bibliographies by topics / Dendritic cells

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  2. Dissertations / Theses
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Academic literature on the topic 'Dendritic cells'

Author: Grafiati
Published: 4 June 2021
Last updated: 31 July 2024

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Journal articles on the topic "Dendritic cells"

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Velte, Toby J., and Richard H. Masland. "Action Potentials in the Dendrites of Retinal Ganglion Cells." Journal of Neurophysiology 81, no. 3 (March 1, 1999): 1412–17. http://dx.doi.org/10.1152/jn.1999.81.3.1412.

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Action potentials in the dendrites of retinal ganglion cells. The somas and dendrites of intact retinal ganglion cells were exposed by enzymatic removal of the overlying endfeet of the Müller glia. Simultaneous whole cell patch recordings were made from a ganglion cell’s dendrite and the cell’s soma. When a dendrite was stimulated with depolarizing current, impulses often propagated to the soma, where they appeared as a mixture of small depolarizations and action potentials. When the soma was stimulated, action potentials always propagated back through the dendrite. The site of initiation of action potentials, as judged by their timing, could be shifted between soma and dendrite by changing the site of stimulation. Applying QX-314 to the soma could eliminate somatic action potentials while leaving dendritic impulses intact. The absolute amplitudes of the dendritic action potentials varied somewhat at different distances from the soma, and it is not clear whether these variations are real or technical. Nonetheless, the qualitative experiments clearly suggest that the dendrites of retinal ganglion cells generate regenerative Na+ action potentials, at least in response to large direct depolarizations.
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Grueber, Wesley B., Lily Y. Jan, and Yuh Nung Jan. "Tiling of the Drosophila epidermis by multidendritic sensory neurons." Development 129, no. 12 (June 15, 2002): 2867–78. http://dx.doi.org/10.1242/dev.129.12.2867.

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Insect dendritic arborization (da) neurons provide an opportunity to examine how diverse dendrite morphologies and dendritic territories are established during development. We have examined the morphologies of Drosophila da neurons by using the MARCM (mosaic analysis with a repressible cell marker) system. We show that each of the 15 neurons per abdominal hemisegment spread dendrites to characteristic regions of the epidermis. We place these neurons into four distinct morphological classes distinguished primarily by their dendrite branching complexities. Some class assignments correlate with known proneural gene requirements as well as with central axonal projections. Our data indicate that cells within two morphological classes partition the body wall into distinct, non-overlapping territorial domains and thus are organized as separate tiled sensory systems. The dendritic domains of cells in different classes, by contrast, can overlap extensively. We have examined the cell-autonomous roles of starry night (stan) (also known as flamingo (fmi)) and sequoia (seq) in tiling. Neurons with these genes mutated generally terminate their dendritic fields at normal locations at the lateral margin and segment border, where they meet or approach the like dendrites of adjacent neurons. However, stan mutant neurons occasionally send sparsely branched processes beyond these territories that could potentially mix with adjacent like dendrites. Together, our data suggest that widespread tiling of the larval body wall involves interactions between growing dendritic processes and as yet unidentified signals that allow avoidance by like dendrites.
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Cazé, Romain D. "Any neuron can perform linearly non-separable computations." F1000Research 10 (July 6, 2021): 539. http://dx.doi.org/10.12688/f1000research.53961.1.

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Multiple studies have shown how dendrites enable some neurons to perform linearly non-separable computations. These works focus on cells with an extended dendritic arbor where voltage can vary independently, turning dendritic branches into local non-linear subunits. However, these studies leave a large fraction of the nervous system unexplored. Many neurons, e.g. granule cells, have modest dendritic trees and are electrically compact. It is impossible to decompose them into multiple independent subunits. Here, we upgraded the integrate and fire neuron to account for saturating dendrites. This artificial neuron has a unique membrane voltage and can be seen as a single layer. We present a class of linearly non-separable computations and how our neuron can perform them. We thus demonstrate that even a single layer neuron with dendrites has more computational capacity than without. Because any neuron has one or more layer, and all dendrites do saturate, we show that any dendrited neuron can implement linearly non-separable computations.
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Cazé, Romain D. "Any neuron can perform linearly non-separable computations." F1000Research 10 (September 16, 2021): 539. http://dx.doi.org/10.12688/f1000research.53961.2.

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Multiple studies have shown how dendrites enable some neurons to perform linearly non-separable computations. These works focus on cells with an extended dendritic arbor where voltage can vary independently, turning dendritic branches into local non-linear subunits. However, these studies leave a large fraction of the nervous system unexplored. Many neurons, e.g. granule cells, have modest dendritic trees and are electrically compact. It is impossible to decompose them into multiple independent subunits. Here, we upgraded the integrate and fire neuron to account for saturating dendrites. This artificial neuron has a unique membrane voltage and can be seen as a single layer. We present a class of linearly non-separable computations and how our neuron can perform them. We thus demonstrate that even a single layer neuron with dendrites has more computational capacity than without. Because any neuron has one or more layer, and all dendrites do saturate, we show that any dendrited neuron can implement linearly non-separable computations.
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Yanagawa, Yoshiki, and Kazunori Onoé. "CCL19 induces rapid dendritic extension of murine dendritic cells." Blood 100, no. 6 (September 15, 2002): 1948–56. http://dx.doi.org/10.1182/blood-2002-01-0260.

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Abstract Dendritic cells (DCs) possess numerous dendrites that may be of great advantage to interaction with T cells. However, it has been poorly understood how the dendritic morphology of a DC is controlled. In the present study, using a murine spleen-derived DC line, we analyzed effects of CCR7 ligands, CCL19 and CCL21, on dendritic morphology. Mature DCs, but not immature DCs, showed vigorous migration to either CCL19 or CCL21. CCL19 also rapidly (within 30 minutes) induced marked extension of dendrites of mature DCs that was maintained at least for 24 hours. On the other hand, CCL21 failed to induce rapid dendritic extension, even though a modest dendritic extension of mature DCs, compared to that by CCL19, was induced 8 or 24 hours after treatment with CCL21. In addition, pretreatment with a high concentration of CCL21 significantly inhibited the rapid dendritic extension induced by CCL19. Thus, it is suggested that CCL19 and CCL21 exert agonistic and antagonistic influences on the initiation of dendritic extension of mature DCs. The CCL19-induced morphologic changes were completely blocked by Clostridium difficiletoxin B that inhibits Rho guanosine triphosphatase proteins such as Rho, Rac, and Cdc42, but not by Y-27632, a specific inhibitor for Rho-associated kinase. These findings suggest that Rac or Cdc42 (or both), but not Rho, are involved in the CCL19-induced dendritic extension of mature DCs.
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Ulrich, Daniel. "Dendritic Resonance in Rat Neocortical Pyramidal Cells." Journal of Neurophysiology 87, no. 6 (June 1, 2002): 2753–59. http://dx.doi.org/10.1152/jn.2002.87.6.2753.

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Dendritic integration of synaptic signals is likely to be an important process by which nerve cells encode synaptic input into spike output. However, the response properties of dendrites to time-varying inputs are largely unknown. Here, I determine the transfer impedance of the apical dendrite in layer V pyramidal cells by dual whole cell patch-clamp recordings in slices of rat somatosensory cortex. Sinusoidal current waveforms of linearly changing frequencies (0.1–25 Hz) were alternately injected into the soma or apical dendrite and the resulting voltage oscillations recorded by the second electrode. Dendrosomatic and somatodendritic transfer impedances were calculated by Fourier analysis. At near physiological temperatures ( T∼35°C), the transfer impedance had a maximal magnitude at low frequencies ( f res ∼6 Hz). In addition, voltage led current up to ∼3 Hz, followed by a current lead over voltage at higher frequencies. Thus the transfer impedance of the apical dendrite is characterized by a low-frequency resonance. The frequency of the resonance was voltage dependent, and its strength increased with dendritic distance. The resonance was completely abolished by the I h channel blocker ZD 7288. Dendrosomatic and somatodendritic transfer properties of the apical dendrite were independent of direction or amplitude of the input current, and the responses of individual versus distributed inputs were additive, thus implying linearity. For just threshold current injections, action potentials were generated preferentially at the resonating frequency. I conclude that due to the interplay of a sag current ( I h) with the membrane capacitance, layer V pyramids can act as linear band-pass filters with a frequency preference in the theta frequency band.
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Schwindt, Peter, and Wayne Crill. "Mechanisms Underlying Burst and Regular Spiking Evoked by Dendritic Depolarization in Layer 5 Cortical Pyramidal Neurons." Journal of Neurophysiology 81, no. 3 (March 1, 1999): 1341–54. http://dx.doi.org/10.1152/jn.1999.81.3.1341.

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Mechanisms underlying burst and regular spiking evoked by dendritic depolarization in layer 5 cortical pyramidal neurons. Apical dendrites of layer 5 pyramidal cells in a slice preparation of rat sensorimotor cortex were depolarized focally by long-lasting glutamate iontophoresis while recording intracellularly from their soma. In most cells the firing pattern evoked by the smallest dendritic depolarization that evoked spikes consisted of repetitive bursts of action potentials. During larger dendritic depolarizations initial burst firing was followed by regular spiking. As dendritic depolarization was increased further the duration (but not the firing rate) of the regular spiking increased, and the duration of burst firing decreased. Depolarization of the soma in most of the same cells evoked only regular spiking. When the dendrite was depolarized to a critical level below spike threshold, intrasomatic current pulses or excitatory postsynaptic potentials also triggered bursts instead of single spikes. The bursts were driven by a delayed depolarization (DD) that was triggered in an all-or-none manner along with the first Na+ spike of the burst. Somatic voltage-clamp experiments indicated that the action current underlying the DD was generated in the dendrite and was Ca2+ dependent. Thus the burst firing was caused by a Na+ spike-linked dendritic Ca2+spike, a mechanism that was available only when the dendrite was adequately depolarized. Larger dendritic depolarization that evoked late, constant-frequency regular spiking also evoked a long-lasting, Ca2+-dependent action potential (a “plateau”). The duration of the plateau but not its amplitude was increased by stronger dendritic depolarization. Burst-generating dendritic Ca2+spikes could not be elicited during this plateau. Thus plateau initiation was responsible for the termination of burst firing and the generation of the constant-frequency regular spiking. We conclude that somatic and dendritic depolarization can elicit quite different firing patterns in the same pyramidal neuron. The burst and regular spiking observed during dendritic depolarization are caused by two types of Ca2+-dependent dendritic action potentials. We discuss some functional implications of these observations.
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Larkum, M. E., M. G. Rioult, and H. R. Luscher. "Propagation of action potentials in the dendrites of neurons from rat spinal cord slice cultures." Journal of Neurophysiology 75, no. 1 (January 1, 1996): 154–70. http://dx.doi.org/10.1152/jn.1996.75.1.154.

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1. We examined the propagation of action potentials in the dendrites of ventrally located presumed motoneurons of organotypic rat spinal cord cultures. Simultaneous patch electrode recordings were made from the dendrites and somata of individual cells. In other experiments we visualized the membrane voltage over all the proximal dendrites simultaneously using a voltage-sensitive dye and an array of photodiodes. Calcium imaging was used to measure the dendritic rise in Ca2+ accompanying the propagating action potentials. 2. Spontaneous and evoked action potentials were recorded using high-resistance patch electrodes with separations of 30-423 microm between the somatic and dendritic electrodes. 3. Action potentials recorded in the dendrites varied considerably in amplitude but were larger than would be expected if the dendrites were to behave as passive cables (sometimes little or no decrement was seen for distances of > 100 microm). Because the amplitude of the action potentials in different dendrites was not a simple function of distance from the soma, we suggest that the conductance responsible for the boosting of the action potential amplitude varied in density from dendrite to dendrite and possibly along each dendrite. 4. The dendritic action potentials were usually smaller and broader and arrived later at the dendritic electrode than at the somatic electrode irrespective of whether stimulation occurred at the dendrite or soma or as a result of spontaneous synaptic activity. This is clear evidence that the action potential is initiated at or near the soma and spreads out into the dendrites. The conduction velocity of the propagating action potential was estimated to be 0.5 m/s. 5. The voltage time courses of previously recorded action potentials were generated at the soma using voltage clamp before and after applying 1 microM tetrodotoxin (TTX) over the soma and dendrites. TTX reduced the amplitude of the action potential at the dendritic electrode to a value in the range expected for dendrites that behave as passive cables. This indicates that the conductance responsible for the actively propagating action potentials is a Na+ conductance. 6. The amplitude of the dendritic action potential could also be initially reduced more than the somatic action potential using 1-10 mM QX-314 (an intracellular sodium channel blocker) in the dendritic electrode as the drug diffused from the dendritic electrode toward the soma. Furthermore, in some cases the action potential elicited by current injection into the dendrite had two components. The first component was blocked by QX-314 in the first few seconds of the diffusion of the blocker. 7. In some cells, an afterdepolarizing potential (ADP) was more prominent in the dendrite than in the soma. This ADP could be reversibly blocked by 1 mM Ni2+ or by perfusion of a nominally Ca2+-free solution over the soma and dendrites. This suggests that the back-propagating action potential caused an influx of Ca2+ predominantly in the dendrites. 8. With the use of a voltage-sensitive dye (di-8-ANEPPS) and an array of photodiodes, the action potential was tracked along all the proximal dendrites simultaneously. The results confirmed that the action potential propagated actively, in contrast to similarly measured hyperpolarizing pulses that spread passively. There were also indications that the action potential was not uniformly propagated in all the dendrites, suggesting the possibility that the distribution of Na+ channels over the dendritic membrane is not uniform. 9. Calcium imaging with the Ca2+ fluorescent indicator Fluo-3 showed a larger percentage change in fluorescence in the dendrites than in the soma. Both bursts and single action potentials elicited sharp rises in fluorescence in the proximal dendrites, suggesting that the back-propagating action potential causes a concomitant rise in intracellular calcium concentration...
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Szakal, A. K., R. L. Gieringer, M. H. Kosco, and J. G. Tew. "Isolated follicular dendritic cells: cytochemical antigen localization, Nomarski, SEM, and TEM morphology." Journal of Immunology 134, no. 3 (March 1, 1985): 1349–59. http://dx.doi.org/10.4049/jimmunol.134.3.1349.

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Abstract The objectives of the present study were to determine the cytological features of isolated follicular dendritic cells (FDC), which distinguish them from other leukocytes or dendritic cell types. Consequently, we have developed methods for the fixation, peroxidase cytochemistry, and visualization of FDC, which are applicable to cytological evaluations by Nomarski optics, scanning, and transmission electron microscopy. A functionally supported identification of FDC in vitro was made possible by utilizing, in conjunction with the dendritic morphology, the cytochemically identifiable antigen, horseradish peroxidase (HRP), and the known capacity of FDC to sequester immune complexes (i.e. HRP-anti-HRP) on their plasma membranes. The observations showed that FDC constitute a relatively pleomorphic, nonphagocytic group, distinct from other dendritic type cells such as lymphoid dendritic cells, Langerhans cells, and interdigitating cells (LDC, LC, and IDC), as well as typical leukocytes. Morphologically distinct FDC were identified as cells either with filiform dendrites or with "beaded" dendrites. FDC possessed a single or sometimes a double, lymphocyte-size cell body, which contained an irregular, lobated nucleus, Golgi apparatus, numerous small vesicles, and some mitochondria. Mitochondria were not abundant in the dendritic processes. Filiform dendrites tended to branch and anastomose near the cell body and form a radiating "sunburst"-like pattern. On the average, dendrites measured 15-20 microns in length and 0.1-0.3 micron in diameter. Occasional dendrites were extremely elongated, reached several hundred microns in length, and terminated in an enlargement measuring nearly a micron in diameter. Other filiform dendrites usually had a club-shaped terminal enlargement. The microspheres of "beaded" dendrites ranged between 0.3 and 0.6 micron in diameter. The dendritic processes were also shown to have a highly ordered pattern of immune complex attachment on their surface, suggestive of a periodic arrangement of receptor sites.
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Hamze, Kassem, Sabine Autret, Krzysztof Hinc, Soumaya Laalami, Daria Julkowska, Romain Briandet, Margareth Renault, et al. "Single-cell analysis in situ in a Bacillus subtilis swarming community identifies distinct spatially separated subpopulations differentially expressing hag (flagellin), including specialized swarmers." Microbiology 157, no. 9 (September 1, 2011): 2456–69. http://dx.doi.org/10.1099/mic.0.047159-0.

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The non-domesticated Bacillus subtilis strain 3610 displays, over a wide range of humidity, hyper-branched, dendritic, swarming-like migration on a minimal agar medium. At high (70 %) humidity, the laboratory strain 168 sfp + (producing surfactin) behaves very similarly, although this strain carries a frameshift mutation in swrA, which another group has shown under their conditions (which include low humidity) is essential for swarming. We reconcile these different results by demonstrating that, while swrA is essential for dendritic migration at low humidity (30–40 %), it is dispensable at high humidity. Dendritic migration (flagella- and surfactin-dependent) of strains 168 sfp + swrA and 3610 involves elongation of dendrites for several hours as a monolayer of cells in a thin fluid film. This enabled us to determine in situ the spatiotemporal pattern of expression of some key players in migration as dendrites develop, using gfp transcriptional fusions for hag (encoding flagellin), comA (regulation of surfactin synthesis) as well as eps (exopolysaccharide synthesis). Quantitative (single-cell) analysis of hag expression in situ revealed three spatially separated subpopulations or cell types: (i) networks of chains arising early in the mother colony (MC), expressing eps but not hag; (ii) largely immobile cells in dendrite stems expressing intermediate levels of hag; and (iii) a subpopulation of cells with several distinctive features, including very low comA expression but hyper-expression of hag (and flagella). These specialized cells emerge from the MC to spearhead the terminal 1 mm of dendrite tips as swirling and streaming packs, a major characteristic of swarming migration. We discuss a model for this swarming process, emphasizing the importance of population density and of the complementary roles of packs of swarmers driving dendrite extension, while non-mobile cells in the stems extend dendrites by multiplication.
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Dissertations / Theses on the topic "Dendritic cells"

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Carnathan, Diane Gail Vilen Barbara J. "Dendritic cell regulation of B cells." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1200.

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Thesis (M.S.)--University of North Carolina at Chapel Hill, 2007.
Title from electronic title page (viewed Mar. 26, 2008). "... in partial fulfillment of the requirements for the degree of Master of Science in the Department of Microbiology and Immunology, School of Medicine." Discipline: Microbiology and Immunology; Department/School: Medicine.
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Liu, Hao. "Dendritic cell development directed by stromal cells." Thesis, University of York, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.516409.

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Hansell, C. A. H. "Identification of avian dendritic cells." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603659.

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The aim of this study was to identify dendritic cells in the chicken through the development of a set of markers and probes to potential dendritic cell markers in the chicken. In the absence of markers to avian dendritic cell markers published sequence databases were used to identify three candidate markers that showed significant homologies to CD83, fascin and DEC205 all potential dendritic cell markers in humans and mice. These markers were chosen for the following reasons: CD83 is currently the best marker of mature human and murine dendritic cells; fascin-1 is an actin bundling protein highly conserved between species, with expression restricted in leukocytes to dendritic cells; and DEC205 is a C-type lectin whose expression is also restricted to dendritic cells. CD83 was expressed in immunologically relevant tissues, had low levels of expression in the bursa and was not detectable on endothelial cell types. Based upon these distributions, CD83 was selected as the most suitable marker of dendritic cells in the chicken and an anti-chicken CD83 polyclonal serum and monoclonal antibodies were used to assess the expression of CD83 at the protein level. A map of CD83 expression was created using immunohistochemistry techniques upon a variety of tissues including spleen thymus and bursa derived from out-bred chickens and specific pathogen free chickens. This data revealed that whilst some aspects of CD83 immunobiology were conserved such as the upregulation of CD83 expression under inflammatory conditions, the distribution of CD83+ cells was uniquely distributed amongst the B cell areas of the chicken immune system in contrast to the T cell associated distribution of humans and mice. The expression of CD83 by specific cellular lineages was determined using commercially available lineage specific monoclonal antibodies and two-colour fluorescent microscopy. This established a dendritic cell type with features that are unique to the chicken.
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Jones, Lucy Helen. "Alternative activation of dendritic cells." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/8284.

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The alternative activation of macrophage populations by Interleukin-4 (IL-4) is well characterised. Alternatively activated macrophages (AAM) express high levels of the arginine converting enzyme arginase-1, and express a plethora of IL-4 driven molecules including the resistin like molecule alpha (RELMα) and the chitinase like molecule Ym1/2. Dendritic cells (DCs) are the professional antigen presenting cells (APC) of the immune system, responsible for the detection of invading pathogens, secretion of cytokines and the subsequent activation of T-cells. This thesis addresses whether IL-4 is able to ‘alternatively activate’ DCs both in vitro and in vivo, in a manner similar to that of AAM. The impact of IL-4 on DC and macrophage activation was compared and contrasted, and it was confirmed for the first time that IL-4 can alternatively activate DCs, inducing high level expression of a range of alternative activation associated markers including RELMα, Ym1/2, CCL24 and dectin-1, with the exception of arginase. DCs were significantly more capable at the in vivo priming of T-cell responses in the context of both Th1 and Th2 polarising antigens than similarly exposed macrophages, confirming their superior capacity as APC. The requirements for DC IL-4Rα expression were assessed, and IL-4 responsiveness was found to be required for the optimal induction of Th1 responses. Conversely, selective loss of only one facet of the IL-4 response, namely RELMα expression, limited the ability of IL-4 exposed DCs to induce the regulatory cytokine IL-10 both in vitro and in vivo. Furthermore, alternatively activated DCs (AADCs) were found in the spleen following 8 weeks of infection with the parasitic trematode Schistosoma mansoni, highlighting a role for DC alternative activation in a disease setting. IL-4 was shown to induce expression of the vitamin A converting enzyme aldehyde dehydrogenase, and the product of such activity, retinoic acid (RA), was found to promote the expression of RELMα in IL-4 exposed DCs. Aldehyde dehydrogenase activity was found to inversely correlate with DC expression of Ym1/2 and inhibition of RA signalling limited IL-4 driven RELMα and promoted Ym1/2.
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Rigby, Rachael Jane. "Intestinal dendritic cells : characterisation of the colonic dendritic cell population and identification of potential precursors." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407134.

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Javorovic, Miran. "T-Cell Stimulation by Melanoma RNA-Pulsed Dendritic Cells." Diss., lmu, 2004. http://nbn-resolving.de/urn:nbn:de:bvb:19-30569.

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Kavikondala, Sushma. "Dendritic cell and B cell interactions in systemic lupuserythematosus." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39793710.

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Kwong, Amelia. "Crosstalk Between T Cells, Dendritic Cells, Cytokines, and Chemokines." Thesis, The University of Arizona, 2010. http://hdl.handle.net/10150/146198.

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T cells that came into contact with mature and immature dendritic cells had an overall reduction in gene expression in IL10, IL12, IL23, ICOS, TGFB, TNFA, PD1, TBET, GATA3, FASL, PERF, FOXP3, and CTLA4. T cells stimulated with immature dendritic cells had the most consistent results in decreasing gene expression in all the genes tested. T cells in contact with mature dendritic cells had mostly a decrease in gene expression, but in IFNG and Granzyme there was an increase in gene expression. However, when adding additional stimuli such as interferon(IFN) or hydroxychloroquine (HCQ) gene expression increased in all of the markers except for TGFB, PERF, and IL12. This leads me to believe that crosstalk is occurring between dendritic cells and T cells. This crosstalk could direct the particular cells to perform specialized functions, which can explain the increase and decrease of the markers tested. In addition, interferon and hydroxychloroquine seems to hyper-stimulate most markers to create an up regulation of gene expression.
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Lee, Michael Hweemoon. "Modulators of Dendritic Cells and B cells in Lupus." Diss., Temple University Libraries, 2019. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/565007.

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Microbiology and Immunology
Ph.D.
Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies directed against ubiquitous self-antigens, many of which are nuclear autoantigens like dsDNA and chromatin (Pisetsky, 2016), and by elevated type I interferons (IFN) (Hooks et al., 1979; Weckerle et al., 2011), a family of pro-inflammatory cytokines that have antiviral activity (Pestka et al., 2004). Microarray analysis of peripheral blood mononuclear cells (PBMC) from SLE patients discovered the increased expression of IFN-responsive genes that was named the IFN Signature (Baechler et al., 2003a; Bennett et al., 2003b; Crow et al., 2003). Genome wide association studies indicate a clear genetic component in lupus pathogenesis (Chung et al., 2011; SLEGEN et al., 2008) and murine models of SLE confirm genetic drivers of the disease (Morel, 2010; Morel et al., 2000). However, the concordance of SLE in monozygotic twins is only 30-40% (Connolly and Hakonarson, 2012), while the inc
Temple University--Theses
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Milioti, Natalia. "Immunomodulation of atherosclerosis using dendritic cells." Thesis, University of Surrey, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608344.

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Inflammation plays a crucial role in atherosclerotic plaque generation/progression. Dendritic cells (DCs). cellular immune-response components linking innate and adaptive immune systems, have been found in atherosclerotic plaques. In this study, Des were examined as a possible therapeutic tool to modulate the inflammatory immune response underlying plaque formation. Apolipoprotein (apo) B-100 derived antigens are believed to modulate humoral immune responses to achieve atheroprotection, but their role in cellular immunity remains unclear. Therefore, one objective was to characterise the immunomodulatory effect of apoB-100-derived peptides (P2, P45, P210) on immature DCs (iDCs) and naive T lymphocytes ill vitro. iDCs were generated from bone-marrow progenitor-cells of male apoE-'- mice. Peptide up-take and processing was studied by confocal microscopy after 6h, 2411 and 48h. Peptide P45 was found in the endolysosomal compartments, co-localising with MHC-I and :MHC-II antigen-presenting complexes. The phenotypic and differentiation characteristics of P2, P45 and P21O-Joaded DCs were studied by flow cytometry, and cytokine and matrix metalloproleinase production by PCR/ELISA after 48h. Proliferation and differentiation of T lymphocytes driven by peptide-loaded DCs was also studied. Peptide-loaded DCs displayed a tolerogenie phenotype similar to that of unloaded, iDCs, and inhibited CD4+ proliferation induced by mature DCs when co-cultured. My results suggest that the protective effect of the peptides could be mediated by DCs presenting them to T cells. A second objective was to examine the effect of vaccination with tolerogenic DCs (toIDCs), generated in vitro through incubation with IL-10 and TGF-β for 6 days, on atherosclerotic progression in apoE-/- mice. This showed that immunisation with tolDCs increased the number of CD8+CD25'FoxP3+ T regulatory cells as well as secretion of IL-l0 within the spleen of immunised mice. IL- l0 levels were also elevated in the serum, while cholesterol levels were reduced, although plaque size remained unchanged. These results provide new insights for treatment and prevention of atherosclerosis through vaccination.
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Books on the topic "Dendritic cells"

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Lombardi, Giovanna, and Yanira Riffo-Vasquez, eds. Dendritic Cells. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-71029-5.

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Sisirak, Vanja, ed. Dendritic Cells. New York, NY: Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-2938-3.

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Ganguly, Dipyaman. Plasmacytoid Dendritic Cells. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-5595-2.

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Reiner, Neil E., ed. Macrophages and Dendritic Cells. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-59745-396-7.

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Salter, Russell D., and Michael R. Shurin, eds. Dendritic Cells in Cancer. New York, NY: Springer US, 2009. http://dx.doi.org/10.1007/978-0-387-88611-4.

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Onji, Morikazu. Dendritic Cells in Clinics. Tokyo: Springer Japan, 2004. http://dx.doi.org/10.1007/978-4-431-67011-7.

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Onji, M. Dendritic cells in clinics. 2nd ed. Tokyo: Springer, 2008.

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Steinkasserer, Alexander, ed. Dendritic Cells and Virus Infection. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-662-06508-2.

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Wu, Li, and Olivier Schwartz, eds. HIV Interactions with Dendritic Cells. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-4433-6.

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A, Steinkasserer, ed. Dendritic cells and virus infection. Berlin: Springer, 2003.

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Book chapters on the topic "Dendritic cells"

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van Kooten, Cees, Annelein S. Stax, Andrea M. Woltman, and Kyra A. Gelderman. "Handbook of Experimental Pharmacology “Dendritic Cells”." In Dendritic Cells, 233–49. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-71029-5_11.

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van de Loosdrecht, A. A., W. van den Ancker, I. Houtenbos, G. J. Ossenkoppele, and T. M. Westers. "Dendritic Cell-Based Immunotherapy in Myeloid Leukaemia: Translating Fundamental Mechanisms into Clinical Applications." In Dendritic Cells, 319–48. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-71029-5_15.

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Lambrecht, Bart N., and Hamida Hammad. "Lung Dendritic Cells: Targets for Therapy in Allergic Disease." In Dendritic Cells, 99–114. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-71029-5_5.

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Rosenblatt, Jacalyn, and David Avigan. "Dendritic Cells." In Allogeneic Stem Cell Transplantation, 807–54. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-59745-478-0_45.

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Dillmann, Christina, Geert R. Van Pottelberge, Ken R. Bracke, and Guy G. Brusselle. "Dendritic Cells." In Nijkamp and Parnham's Principles of Immunopharmacology, 55–68. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-10811-3_5.

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Goyne, Hannah E., and Martin Cannon. "Dendritic Cells." In Cancer Therapeutic Targets, 171–81. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4419-0717-2_62.

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Cools, Nathalie, Viggo Van Tendeloo, and Zwi Berneman. "Dendritic Cells." In Encyclopedia of Cancer, 1–5. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27841-9_1556-2.

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Pulendran, Bali, Anshu Agrawal, Stephanie Dillon, and Sudhanshu Agrawal. "Dendritic Cells." In Vaccine Adjuvants, 25–38. Totowa, NJ: Humana Press, 2006. http://dx.doi.org/10.1007/978-1-59259-970-7_2.

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El Ali, Zeina, Romain Génard, Marie de Bourayne, Marc Pallardy, and Saadia Kerdine-Römer. "Dendritic Cells." In Compendium of Inflammatory Diseases, 439–48. Basel: Springer Basel, 2016. http://dx.doi.org/10.1007/978-3-7643-8550-7_102.

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Avigan, David. "Dendritic Cells." In Allogeneic Stem Cell Transplantation, 411–38. Totowa, NJ: Humana Press, 2003. http://dx.doi.org/10.1007/978-1-59259-333-0_26.

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Conference papers on the topic "Dendritic cells"

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Meier, D. L., R. H. Hopkins, and R. B. Campbell. "Dendritic Web Silicon Solar Cells." In 22nd Intersociety Energy Conversion Engineering Conference. Reston, Virginia: American Institute of Aeronautics and Astronautics, 1987. http://dx.doi.org/10.2514/6.1987-9056.

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Chen, Aaron C. H., Ying-Ying Huang, Sulbha K. Sharma, and Michael R. Hamblin. "Can dendritic cells see light?" In BiOS, edited by Wei R. Chen. SPIE, 2010. http://dx.doi.org/10.1117/12.842959.

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Greensmith, Julie, and Uwe Aickelin. "Dendritic cells for SYN scan detection." In the 9th annual conference. New York, New York, USA: ACM Press, 2007. http://dx.doi.org/10.1145/1276958.1276966.

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CAVALCANTE, WANESSA SIQUEIRA, SHEYLA BATISTA BOLOGNA LOPES, SILVIA VANESSA LOURENCO, LUIZ FERNANDO FERRAZ DA SILVA, and MARCELLO MENTA SIMONSEN NICO. "DENDRITIC CELLS IN PRIMARY SJOGREN'S SYNDROME." In 36º Congresso Brasileiro de Reumatologia. São Paulo: Editora Blucher, 2019. http://dx.doi.org/10.5151/sbr2019-391.

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Xu, Q. Y., W. M. Feng, and B. C. Liu. "3D Stochastic Modeling of As-Cast Microstructure for Aluminum Alloy Casting." In ASME 2002 International Mechanical Engineering Congress and Exposition. ASMEDC, 2002. http://dx.doi.org/10.1115/imece2002-32894.

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A 3D stochastic modeling was carried out to simulate the dendritic grains during solidification process of aluminum alloy, including time-dependent calculations for temperature field, solute redistribution in liquid, curvature of the dendritic tip, and growth anisotropy. The nucleation process was calculated by continuous nucleation. A 3D simplified grain shape model was established to represent the equiaxed dendritic grain. Based on the Cellular Automaton method, a grain growth model was proposed to capture the neighbor cells of the nucleated cell. On growing, each grain continues to capture the nearest neighbor cells to form the final shape. When a neighboring cell has been captured by the other grains, the grain growth along this direction is stopped. Three-dimensional calculations were performed to simulate the evolution of dendritic grain. In order to verify the modeling results, aluminum alloy sample castings were cast in sand and metal mold.
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Rodieck, Robert W. "Primate ganglion cells: types, distribution, and pathways." In OSA Annual Meeting. Washington, D.C.: Optica Publishing Group, 1987. http://dx.doi.org/10.1364/oam.1987.wd2.

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Until recently, little was known of the different cell types of the primate retina, other than from Golgi studies of cells seen in transverse section. The development of an in vitro preparation, which allows identified cells to be intracellularly injected with a marker able to reveal their full dendritic morphology, has greatly increased our understanding of the distinct ganglion cell types present.
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Meier, D. L., J. A. Spitznagel, J. Greggi, and R. B. Campbell. "Antimony-doped dendritic web silicon solar cells." In Conference Record of the Twentieth IEEE Photovoltaic Specialists Conference. IEEE, 1988. http://dx.doi.org/10.1109/pvsc.1988.105735.

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Suzuki, Yuzo, Takafumi Suda, Kiyoshi Shibata, Kazuki Furuhashi, Dai Hashimoto, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Naoki Inui, and Kingo Chida. "CD11bhigh Lung Dendritic Cells Are More Potent To Induce LGA Class Switch Recombination Than CD103+ Lung Dendritic Cells." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2840.

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Wiernik, Andres, and Jeffrey S. Miller. "Abstract 533: Dendritic cells are professional educators of Natural Killer cells." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-533.

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Demanche, A., M. Girard, E. Israel-Assayag, and Y. Cormier. "Phenotypical Changes of Dendritic Cells Exposed toSaccharopolyspora rectivirgula." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a5631.

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Reports on the topic "Dendritic cells"

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Miller, George. Divergent Effects of Dendritic Cells on Pancreatitis. Fort Belvoir, VA: Defense Technical Information Center, September 2015. http://dx.doi.org/10.21236/ada624310.

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Brittingham, Katherine C., Gordon Ruthel, Rekha G. Panchal, Claudette L. Fuller, and Wilson J. Ribot. Dendritic Cells Endocytose Bacillus Anthracis Spores: Implications for Anthrax Pathogenesis. Fort Belvoir, VA: Defense Technical Information Center, February 2005. http://dx.doi.org/10.21236/ada434591.

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Guruli, Georgi. Activation and Protection of Dendritic Cells in the Prostate Cancer Environment. Fort Belvoir, VA: Defense Technical Information Center, February 2009. http://dx.doi.org/10.21236/ada508758.

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Guruli, Georgi, and Mark L. Jordan. Activation and Protection of Dendritic Cells in the Prostate Cancer Environment. Fort Belvoir, VA: Defense Technical Information Center, February 2007. http://dx.doi.org/10.21236/ada467561.

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Kim, Seon-Hee. Breast Cancer Immunotherapy with Intra-Tumoral Injection of Genetically Modified Dendritic Cells. Fort Belvoir, VA: Defense Technical Information Center, July 2002. http://dx.doi.org/10.21236/ada412918.

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Guruli, Georgi. Activation and Protection of Dendritic Cells in the Prostate Cancer Environment. Addendum. Fort Belvoir, VA: Defense Technical Information Center, January 2011. http://dx.doi.org/10.21236/ada545297.

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Beg, Amer A. Potentiation of T Lymphocyte Responses by Modulating NF-kB Activity in Dendritic Cells. Fort Belvoir, VA: Defense Technical Information Center, June 2004. http://dx.doi.org/10.21236/ada437633.

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Gilboa, Eli. Immunotherapy of Metastatic Prostate Cancer Using Dendritic Cells Pulsed with Normal Prostate Tissue Antigens. Fort Belvoir, VA: Defense Technical Information Center, March 2001. http://dx.doi.org/10.21236/ada395669.

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Beg, Amer A. Potentiation of T Lymphocyte Responses by Modulating NF - Kappa Beta Activity in Dendritic Cells. Fort Belvoir, VA: Defense Technical Information Center, June 2003. http://dx.doi.org/10.21236/ada417929.

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Gilboa, Eli. Immunotheraphy of Metastatic Prostate Cancer Using Dendritic Cells Pulsed with Normal Prostate Tissue Antigens. Fort Belvoir, VA: Defense Technical Information Center, September 1999. http://dx.doi.org/10.21236/ada390524.

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