Academic literature on the topic 'Denʹ'
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Journal articles on the topic "Denʹ"
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Blaney, Joseph E., Jennifer M. Matro, Brian R. Murphy, and Stephen S. Whitehead. "Recombinant, Live-Attenuated Tetravalent Dengue Virus Vaccine Formulations Induce a Balanced, Broad, and Protective Neutralizing Antibody Response against Each of the Four Serotypes in Rhesus Monkeys." Journal of Virology 79, no. 9 (May 1, 2005): 5516–28. http://dx.doi.org/10.1128/jvi.79.9.5516-5528.2005.
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ABSTRACT Three tetravalent vaccine (TV) formulations of previously described monovalent dengue (DEN) virus vaccine candidates were compared to a tetravalent formulation of wild-type DEN viruses (T-wt) for replication in SCID mice transplanted with human liver cells (SCID-HuH-7) or for replication and immunogenicity in rhesus monkeys. TV-1 consists of recombinant DEN1, -2, -3, and -4, each with a 30-nucleotide deletion in the 3′ untranslated region (Δ30). TV-2 consists of rDEN1Δ30, rDEN4Δ30, and two antigenic chimeric viruses, rDEN2/4Δ30 and rDEN3/4Δ30, both also bearing the Δ30 mutation. TV-3 consists of rDEN1Δ30, rDEN2Δ30, rDEN4Δ30, and a 10-fold higher dose of rDEN3/4Δ30. TV-1 and TV-2 were attenuated in SCID-HuH-7 mice with minimal interference in replication among the virus components. TV-1, -2, and -3 were attenuated in rhesus monkeys as measured by duration and peak of viremia. Each monkey immunized with TV-1 and TV-3 seroconverted to the four DEN components by day 28 with neutralization titers ranging from 1:52 to 1:273 and 1:59 to 1:144 for TV-1 and TV-3, respectively. TV-2 induced low antibody titers to DEN2 and DEN3, but a booster immunization after 4 months increased the neutralizing antibody titers to greater than 1:100 against each serotype and elicited broad neutralizing activity against 19 of 20 DEN subtypes. A single dose of TV-2 induced protection against wild-type DEN1, DEN3, and DEN4 challenge, but not DEN2. However, two doses of TV-2 or TV-3 induced protection against DEN2 challenge. Two tetravalent formulations, TV-2 and TV-3, possess properties of a successful DEN vaccine and can be considered for evaluation in clinical trials.
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Guirakhoo, F., J. Arroyo, K. V. Pugachev, C. Miller, Z. X. Zhang, R. Weltzin, K. Georgakopoulos, et al. "Construction, Safety, and Immunogenicity in Nonhuman Primates of a Chimeric Yellow Fever-Dengue Virus Tetravalent Vaccine." Journal of Virology 75, no. 16 (August 15, 2001): 7290–304. http://dx.doi.org/10.1128/jvi.75.16.7290-7304.2001.
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ABSTRACT We previously reported construction of a chimeric yellow fever-dengue type 2 virus (YF/DEN2) and determined its safety and protective efficacy in rhesus monkeys (F. Guirakhoo et al., J. Virol. 74:5477–5485, 2000). In this paper, we describe construction of three additional YF/DEN chimeras using premembrane (prM) and envelope (E) genes of wild-type (WT) clinical isolates: DEN1 (strain PUO359, isolated in 1980 in Thailand), DEN3 (strain PaH881/88, isolated in 1988 in Thailand), and DEN4 (strain 1228, isolated in 1978 in Indonesia). These chimeric viruses (YF/DEN1, YF/DEN3, and YF/DEN4) replicated to ∼7.5 log10 PFU/ml in Vero cells, were not neurovirulent in 3- to 4-week-old ICR mice inoculated by the intracerebral route, and were immunogenic in monkeys. All rhesus monkeys inoculated subcutaneously with one dose of these chimeric viruses (as monovalent or tetravalent formulation) developed viremia with magnitudes similar to that of the YF 17D vaccine strain (YF-VAX) but significantly lower than those of their parent WT viruses. Eight of nine monkeys inoculated with monovalent YF/DEN1 -3, or -4 vaccine and six of six monkeys inoculated with tetravalent YF/DEN1-4 vaccine seroconverted after a single dose. When monkeys were boosted with a tetravalent YF/DEN1-4 dose 6 months later, four of nine monkeys in the monovalent YF/DEN groups developed low levels of viremia, whereas no viremia was detected in any animals previously inoculated with either YF/DEN1-4 vaccine or WT DEN virus. An anamnestic response was observed in all monkeys after the second dose. No statistically significant difference in levels of neutralizing antibodies was observed between YF virus-immune and nonimmune monkeys which received the tetravalent YF/DEN1-4 vaccine or between tetravalent YF/DEN1-4-immune and nonimmune monkeys which received the YF-VAX. However, preimmune monkeys developed either no detectable viremia or a level of viremia lower than that in nonimmune controls. This is the first recombinant tetravalent dengue vaccine successfully evaluated in nonhuman primates.
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Lebed, Iryna, and Khrystyna Bilohrats. "HEADINGS OF PUBLICATIONS IN THE MEDIA ON THE EXAMPLE OF THE NEWSPAPER “DENʹ” AND MAGAZINE “KRAYINA”." Bulletin of Lviv Polytechnic National University. Series: Journalistic sciences 2020, no. 4 (June 2020): 63–67. http://dx.doi.org/10.23939/sjs2020.01.063.
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Tomia, Amalan, and Rosmila Tuharea. "Dengue Virus Detection Using Rt-Pcr Method In Ternate City, North Maluku, Indonesia." International Journal of Health and Pharmaceutical (IJHP) 2, no. 4 (August 7, 2022): 622–26. http://dx.doi.org/10.51601/ijhp.v2i4.98.
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The Dengue disease is caused by a virus from the family Flaviviridae and there are four distinct, but closely related, virus serotypes that cause dengue (DENV-1, DENV-2, DENV-3 and DENV-4). Dengue virus detection is very important to determine the virus serotype that develops in an area. There are several methods to detect dengue virus based on different targets, namely nucleic acids, viral antigens, and antibodies. This study aims to determine the type of dengue virus serotype in four working areas of the Public Health Center in Ternate City. The sample in this study was the eggs of Aedes sp mosquitoes caught in the homes of DHF sufferers and the houses around them. Collection of mosquito eggs Ae. Aegypti was carried out in four Puskesmas working areas in Ternate City. Ovitrap installation was carried out in 200 houses, with a total of 400 ovitraps. Rearing eggs and dengue virus detection were carried out at the Microbiology Laboratory, LITBAGKES Banjarnegara. The method used in this research is the RT-PCR test. The data analysis of the research results was carried out descriptively. Based on the identification results, the mosquito used in this study was the Aede aegypti mosquito. The results of electrophoresis produced viral RNA with a base length of 100 bp, while the target RNA that had been determined were Den1 = 342 bp, Den2 = 251 bp, Den3 = 538 bp. Den4 = 752 bp. The results of the RT-PCR examination showed that the Ae. aegypti in the four working areas of the Puskesmas did not contain the dengue virus (virus negative).
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Real-Cotto, Jhony Joe, Mary Ernestina Regato Arrata, Virginia Elisa Burgos Yépez, and Eduardo Tarquino Jurado Cobeña. "Evolución del virus dengue en el Ecuador. Período 2000 a 2015." Anales de la Facultad de Medicina 78, no. 1 (May 16, 2017): 29. http://dx.doi.org/10.15381/anales.v78i1.13018.
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Introducción. Actualmente la infección por virus dengue constituye una de las arbovirosis más importantes y de amplia distribución en las regiones tropicales y subtropicales del planeta. Objetivo. Determinar la evolución del virus dengue circulante en el Ecuador durante el periodo 2000 a 2015. Diseño. Estudio no experimental, transversal, de tipo descriptivo y correlacional; Lugar. Unidades de salud del Ecuador. Participantes. Muestras tomadas a sospechosos de dengue con menos de 5 días de iniciada su enfermedad. Resultados. En el año 2000 se tuvo la presencia de los 4 serotipos, con predominio del DEN3 durante 2001 al 2006, coincidentes con los incrementos de casos del 2000, 2001 y 2005; en el año 2004 reapareció el virus DEN1 y los años siguientes su presencia predominó entre 2007 y 2012, coincidiendo con el incremento de casos en el 2010. Del año 2011 al 2015 se presentaron 3 virus circulantes a la vez (DEN1, DEN2 y DEN4), en 2014 y 2015 hubo la presencia del virus DEN3, con predominio del virus DEN2 en 2013 y 2014 y virus DEN1 en 2015; y ha sido la provincia del Guayas la de mayor relación con los virus. Conclusiones. La presencia de varios serotipos de virus dengue circulando a la vez y su permanencia se debería a otros factores que están influenciando en el comportamiento del virus, con una variabilidad de los cuatro serotipos. Se debe fortalecer la vigilancia molecular de la circulación de serotipos, genotipos y linajes del virus dengue.
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Calvert, Amanda E., Claire Y. H. Huang, Richard M. Kinney, and John T. Roehrig. "Non-structural proteins of dengue 2 virus offer limited protection to interferon-deficient mice after dengue 2 virus challenge." Journal of General Virology 87, no. 2 (February 1, 2006): 339–46. http://dx.doi.org/10.1099/vir.0.81256-0.
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Chimeric (D2/WN) viruses containing the pre-membrane (prM) and envelope (E) proteins of West Nile virus (WN virus) and the capsid (C) and non-structural proteins of dengue 2 (DEN2) virus were used to evaluate the protective immunity elicited by either the flaviviral E protein or non-structural proteins. AG129 interferon-deficient mice, previously shown to be protected against lethal DEN1 or DEN2 viral infection after vaccination with a wild-type or candidate vaccine strain of DEN1 or DEN2 virus, respectively, were immunized with chimeric D2/WN virus and then challenged with DEN2 virus. D2/WN chimeric viruses were non-pathogenic in AG129 mice. These viruses elicited little anti-DEN E antibody, high levels of anti-DEN NS1 antibody and no or very low levels of DEN2 virus-neutralizing antibodies. Only 15 % of D2/WN-immunized mice survived challenge with DEN2 virus. However, their mean survival time increased by 11–14 days over non-immunized controls. These results suggest that, whilst the non-structural proteins were able to enhance mean survival times of AG129 mice, this protection was not as effective as protection mediated by the E protein.
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Whitehead, Stephen S., Barry Falgout, Kathryn A. Hanley, Joseph E. Blaney,, Lewis Markoff, and Brian R. Murphy. "A Live, Attenuated Dengue Virus Type 1 Vaccine Candidate with a 30-Nucleotide Deletion in the 3′ Untranslated Region Is Highly Attenuated and Immunogenic in Monkeys." Journal of Virology 77, no. 2 (January 15, 2003): 1653–57. http://dx.doi.org/10.1128/jvi.77.2.1653-1657.2003.
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ABSTRACT The Δ30 deletion mutation, which was originally created in dengue virus type 4 (DEN4) by the removal of nucleotides 172 to 143 from the 3′ untranslated region (3′ UTR), was introduced into a homologous region of wild-type (wt) dengue virus type 1 (DEN1). The resulting virus, rDEN1Δ30, was attenuated in rhesus monkeys to a level similar to that of the rDEN4Δ30 vaccine candidate. rDEN1Δ30 was more attenuated in rhesus monkeys than the previously described vaccine candidate, rDEN1mutF, which also contains mutations in the 3′ UTR, and both vaccines were highly protective against challenge with wt DEN1. Both rDEN1Δ30 and rDEN1mutF were also attenuated in HuH-7-SCID mice. However, neither rDEN1Δ30 nor rDEN1mutF showed restricted replication following intrathoracic inoculation in the mosquito Toxorhynchites splendens. The ability of the Δ30 mutation to attenuate both DEN1 and DEN4 viruses suggests that a tetravalent DEN vaccine could be generated by introduction of the Δ30 mutation into wt DEN viruses belonging to each of the four serotypes.
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N., Ravindra B., Lipika Das, Darshan J. C., Sayantan Ghosh, Berlin P. Kurian, Prolay Paul, Meghana A. Reddy, and Satish Kumar B. P. "Community transmission of a virus: a global pandemic overview." International Journal Of Community Medicine And Public Health 8, no. 3 (February 24, 2021): 1518. http://dx.doi.org/10.18203/2394-6040.ijcmph20210856.
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The word ‘pandemic’ was originally a derivative from two Greek words “pan” referring “all” and “demos” “people”. “An epidemic arising over a very diverse area, crossing the global margins, and typically affecting a huge number of people” is defined as a pandemic. Therefore pandemics are recognized by their topographical scale instead of severity of ailments. Even though the term “pandemic” has not been clearly defined, wide geographic extension, disease movement, novelty, severity, high attack rates and explosiveness, minimal population immunity, infectiousness and contagiousness can be considered as some of the key features of this term. Till today, globe has encountered several notable pandemics caused by virus such as Spanish flu, acquired immune deficiency syndrome (HIV/AIDS), smallpox, SARS, Ebola and Nipah disease whose causative organisms are H1N1, human immunodeficiency virus (HIV), Variola virus, DEN-1/DEN2/DEN3/DEN4, coronavirus, Ebola virus (Zaire/Sudan/Tai/Cote D’ivoire), and Nipah virus (NiV) respectively. This review includes detailed data regarding various viral pandemics. Analyzing the history, clinical manifestation, pathogenesis, management and precautions of several viral pandemics which will promote and spread the awareness among the public as well as the healthcare system.
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Umareddy, Indira, Kin Fai Tang, Subhash G. Vasudevan, Shamala Devi, Martin L. Hibberd, and Feng Gu. "Dengue virus regulates type I interferon signalling in a strain-dependent manner in human cell lines." Journal of General Virology 89, no. 12 (December 1, 2008): 3052–62. http://dx.doi.org/10.1099/vir.0.2008/001594-0.
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Outbreaks of dengue disease are constant threats to tropical and subtropical populations but range widely in severity, from mild to haemorrhagic fevers, for reasons that are still elusive. We investigated the interferon (IFN) response in infected human cell lines A549 and HepG2, using two strains (NGC and TSV01) of dengue serotype 2 (DEN2) and found that the two viruses exhibited a marked difference in inducing type I IFN response. While TSV01 infection led to activation of type I antiviral genes such as EIF2AK2 (PKR), OAS, ADAR and MX, these responses were absent in NGC-infected cells. Biochemical analysis revealed that NGC but not TSV01 suppressed STAT-1 and STAT-2 activation in response to type I IFN (α and β). However, these two strains did not differ in their response to type II IFN (γ). Although unable to suppress IFN signalling, TSV01 infection caused a weaker IFN-β induction compared with NGC, suggesting an alternative mechanism of innate immune escape. We extended our study to clinical isolates of various serotypes and found that while MY10245 (DEN2) and MY22713 (DEN4) could suppress the IFN response in a similar fashion to NGC, three other strains of dengue [EDEN167 (DEN1), MY02569 (DEN1) and MY10340 (DEN2)] were unable to suppress the IFN response, suggesting that this difference is strain-dependent but not serotype-specific. Our report indicates the existence of a strain-specific virulence factor that may impact on disease severity.
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McGee, Brady K., Warren B. Ballard, and Kerry L. Nicholson. "Swift Fox, Vulpes velox, Den Use Patterns in Northwestern Texas." Canadian Field-Naturalist 121, no. 1 (January 1, 2007): 71. http://dx.doi.org/10.22621/cfn.v121i1.396.
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Predator avoidance may be a reason why Swift Foxes (Vulpes velox) are one of the most burrow-dependent canids in North America. Typically Swift Foxes have multiple dens, which they frequently move among. As part of a larger study to reduce Coyote (Canis latrans) related mortalities on Swift Foxes, we installed artificial escape dens in areas occupied by Swift Foxes on Rita Blanca National Grassland, Dallam County, Texas. For this paper, our objective was to determine the effects of artificial escape dens on Swift Fox den use patterns. From January 2002 to August 2004 we captured, radio-collared, and monitored 55 Swift Foxes. We documented annual number of dens used, rate of den use (fidelity), distance between dens, den area, and den sharing. We compared treated (artificial dens installed) and untreated (no artificial dens) areas but found no differences in annual number of dens (P = 0.64; mean = 8), rate of den use (P = 0.96; mean = 35%), mean distance between dens (P = 0.99; mean = 2,311 m), den area (P = 0.55; mean = 5.72 km2), or den sharing (P = 0.46; mean = 42% of time). We did not observe an effect of artificial escape dens on Swift Fox den use patterns probably because artificial escape dens were designed for temporary escape cover rather than diurnal den use.
Dissertations / Theses on the topic "Denʹ"
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Silva, Ana Am?lia Bianchi e. "Influ?ncia do preparo cavit?rio e do material restaurador na carga e no tipo de fratura de premolares tratados endodonticamente." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2008. http://tede2.pucrs.br/tede2/handle/tede/994.
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Previous issue date: 2008-09-16Este trabalho avaliou a influ?ncia de diferentes t?cnicas restauradoras na carga e no tipo de fratura em premolares tratados endodonticamente. Sessenta premolares superiores foram divididos nos seguintes grupos: G1 h?gidos; G2 cavidade MOD e restaura??o direta com Four Season tipo inlay; G3 cavidade MOD e restaura??o indireta com Adoro tipo inlay; G5 cavidade MOD e restaura??o com Empress tipo inlay; G4 e G6 semelhantes aos grupos 3 e 5, respectivamente, mas com cobertura de c?spides (tipo onlay). Foi realizada endodontia nos grupos 2 a 6. Os corpos-de-prova foram submetidos ao ensaio de compress?o em m?quina de ensaio universal com velocidade de 0,5 mm/minuto. O tipo de fratura foi classificado da seguinte forma: fratura tipo I restrita ? restaura??o; fratura tipo II restaura??o e c?spide dent?ria acima da jun??o amelocement?ria; fratura tipo III restaura??o e c?spide dent?ria abaixo da jun??o amelocement?ria; fratura tipo IV restaura??o e c?spide abaixo da jun??o amelocement?ria com exposi??o da c?mara pulpar; fratura tipo V ao longo da raiz. As m?dias dos valores de carga de fratura foram submetidos ? An?lise de Vari?ncia e Teste de Tukey, e os resultados do tipo de fratura foram submetidos ao teste Kruskal-Wallis ao n?vel de signific?ncia foi de 5%. Houve diferen?a estatisticamente significante na carga de fratura entre os grupos (p=0,01). O maior valor de carga de fratura foi obtido no grupo dos dentes h?gidos (1370,61 N), n?o diferindo estatisticamente do grupo onlay em Empress (1304,21 N), sendo ambos os valores estatisticamente superiores aos demais grupos. Valores intermedi?rios foram obtidos para os grupos inlay em Empress (918,76 N), onlay em Adoro (861,15 N) e inlay em Adoro (792,71 N), os quais n?o diferiram estatisticamente entre si. O menor valor de carga de fratura foi obtido para o grupo da restaura??o direta com Four Season (666,08 N), n?o diferindo estatisticamente do grupo inlay em Adoro. Tamb?m houve diferen?a estat?stica significativa para o tipo de fratura entre os grupos (p=0,001). Os grupos onlay em Adoro e h?gidos n?o diferiram estatisticamente entre si, apresentando maior porcentagem de fraturas com melhor progn?stico (sem exposi??o da c?mara pulpar), e nenhum dente com fratura ao longo da raiz. J? os demais grupos experimentais tamb?m n?o diferiram estatisticamente entre si, mas todos apresentaram fraturas se estendendo ao longo da raiz (pior progn?stico).
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Nemanja, Lakicevic. "Harmonidynamiske prosesser i verket Kontratanker : Den primære idé og dens utvikling." Thesis, Kungl. Musikhögskolan, Institutionen för komposition, dirigering och musikteori, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kmh:diva-2142.
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Paranhos, Maria Paula Gandolfi. "Tratamentos de superf?cie para aumentar a resist?ncia de uni?o adesiva ? zirc?nia." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2010. http://tede2.pucrs.br/tede2/handle/tede/1092.
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Previous issue date: 2010-08-06Foram realizados dois estudos in vitro para avaliar resist?ncia de uni?o de cimentos resinosos ? zirc?nia ap?s diferentes tratamentos de superf?cie e um estudo in vitro para avaliar a resist?ncia ? fadiga de coroas n?o-retentivas cimentadas adesivamente em pilares de zirc?nia conforme protocolo adesivo definido pelos estudos de resist?ncia de uni?o.
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Magitot, Émile. "Étude sur le développement et la structure des dents humaines, accompagnée de deux planches gravées sur cuivre thèse pour le doctorat en médecine présentée et soutenue le 29 décembre 1857 /." Paris : BIUM, 2003. http://www.bium.univ-paris5.fr/histmed/medica/cote?TPAR1857x287.
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Ruppert, Stefanie [Verfasser]. "Globaler Terrorismus in den Lebens-, Denk- und Sprechwelten von Jugendlichen / Stefanie Ruppert." Mainz : Universitätsbibliothek der Johannes Gutenberg-Universität Mainz, 2020. http://d-nb.info/1224896459/34.
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Melara, Rafael. "Avalia??o da aplica??o de uma solu??o ?cida experimental na resist?ncia de uni?o de sistemas adesivos." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2011. http://tede2.pucrs.br/tede2/handle/tede/1112.
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Previous issue date: 2011-01-21Este estudo teve por objetivo avaliar, in vitro, a resist?ncia de uni?o dos sistemas adesivos Adper Scotchbond SE (3M/ESPE) e Adper Scotchbond Multi-Uso (3M/ESPE) ? superf?cie dentin?ria tratada ou n?o com uma solu??o ?cida experimental. A superf?cie oclusal de vinte terceiros molares humanos h?gidos foi removida para a obten??o de uma ?rea plana de dentina. Os dentes foram divididos em 4 grupos, de acordo com o tipo de sistema adesivo usado e aplica??o ou n?o da solu??o experimental. Nos grupos Adper Scotchbond SE Controle e Adper Scotchbond Multi-Uso Controle, o sistema adesivo foi aplicado de acordo com as instru??es do fabricante. No grupo Adper Scotchbond SE Experimental foi aplicada a solu??o experimental previamente ao sistema adesivo, e no grupo Adper Scotchbond Multi-Uso Experimental, o condicionamento com ?cido fosf?rico a 37% foi substitu?do pela aplica??o da solu??o experimental. Ap?s a aplica??o do sistema adesivo, um bloco de resina composta (Z350 - 3M/ESPE), com aproximadamente 6 mm de altura, foi confeccionado, sendo os dentes armazenados em ?gua destilada por 24 h em uma estufa de cultura a 37?C. Decorrido este per?odo, os dentes foram seccionados nos sentido x e y a fim de obter palitos com ?rea adesiva de aproximadamente 1,0 mm2. Dezesseis palitos por grupo foram submetidos ao teste de microtra??o em uma m?quina de ensaios (EMIC DL-2000), a uma velocidade de 0,5 mm/min. Ap?s o teste de microtra??o, os palitos foram avaliados em microscopia eletr?nica de varredura, para estabelecimento do padr?o predominante de falha, por meio de fractografia. De acordo com a an?lise de vari?ncia segundo duas vias n?o houve diferen?a estatisticamente significativa nos valores de resist?ncia de uni?o entre os quatro grupos, para os fatores adesivos e tratamentos de superf?cie. O tipo de falha predominante observado em MEV foi coesiva em adesivo, seguido de coesiva em camada h?brida. A an?lise em MEV mostrou que a solu??o experimental foi capaz de remover a smear layer expondo t?bulos dentin?rios. Com base nos resultados encontrados ? poss?vel concluir que o uso da solu??o experimental contendo um inibidor de metaloproteinases, em associa??o aos sistemas adesivos estudados, foi capaz de promover valores de resist?ncia de uni?o 3 semelhantes ? t?cnica de aplica??o recomendada pelos fabricantes; e que essa solu??o ?cida experimental foi capaz de obter um padr?o de condicionamento de superf?cie dentin?ria semelhante ao obtido com o ?cido fosf?rico a 37%.
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Stona, Deborah. "Avalia??o da resist?ncia ? fratura de coroas CAD-CAM sobre pilares s?lidos." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2014. http://tede2.pucrs.br/tede2/handle/tede/1263.
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Previous issue date: 2014-02-25The aim of the study was to evaluate the fracture resistance of ceramic crowns using Cerec CAD-CAM system on solid pillars. Sixty replica synocta implant and RN solid abutment were embedded in acrylic resin, being randomly assigned (n=20 per group). Three types of ceramics were used: Mark II (feldspar), IPS Empress CAD (leucite) and IPS e.max CAD (lithium disilicate). The crowns were fabricated by CAD-CAM system using the Cerec software version 4.1. After receiving glaze and were cemented with RelyX U200 cement under load of 1 Kg Half of the specimens of each ceramic was subjected to endurance EMIC DL-2000 test fracture in a universal testing machine with a speed of 1 mm / minute and the other half after 1,000,000 cycles of mechanical stress with a load of 100 N. According to two-way ANOVA, the interaction between the material and mechanical cycling was significant (p = 0.0001). According to Tukey test (α = 5%) the fracture toughness without mechanical cycling and mechanical cycling, respectively, of Mark II (405N/454N) was statistically lower than ceramic IPS Empress CAD (1169N/1240N) and IPS e.max CAD (1378N/1025N) (p < 0.05). The ceramic IPS Empress CAD and IPS e.max CAD not differ statistically (p > 0.05). There was no statistical difference in the resistance to cyclic loading with and without fracture to the Mark II and IPS Empress CAD (p > 0.05, Student's t test) ceramics. For ceramic IPS e.max CAD, the fracture resistance without mechanical cycling was statistically superior to that obtained with cycling (p < 0.05). The ceramic IPS Empress CAD and IPS e.max CAD showed higher fracture resistance compared to ceramic Mark II. The cyclic loading negatively influenced only IPS e.max CAD.
O objetivo do estudo foi avaliar a resist?ncia ? fratura de coroas cer?micas utilizando o sistema CAD-CAM Cerec sobre pilares s?lidos. Sessenta r?plicas de implante synocta RN e pilar s?lido foram inclu?dos em resina acr?lica autopolimeriz?vel, sendo divididas aleatoriamente (n=20 por grupo). Tr?s tipos de cer?micas foram utilizadas: Mark II (feldsp?tica), IPS Empress CAD (leucita) e IPS e.max CAD (dissilicato de l?tio). As coroas foram confeccionadas atrav?s do sistema CAD-CAM utilizando o software Cerec vers?o 4.1. Ap?s receberam glaze e foram cimentadas com RelyX U200 sob carga de cimenta??o de 1 Kg. Metade dos corpos de prova de cada cer?mica foi submetida ao teste de resist?ncia ? fratura em m?quina de ensaio universal EMIC-DL 2000 com velocidade de 1 mm/minuto e, a outra metade, ap?s 1.000.000 de ciclos de fadiga mec?nica com carga de 100 N. Segundo ANOVA de duas vias, a intera??o entre material e ciclagem mec?nica foi significativa (p=0,0001). De acordo com o teste de Tukey (α=5%) a resist?ncia ? fratura, sem ciclagem mec?nica e com ciclagem mec?nica respectivamente, da cer?mica Mark II (405N/454N) foi estatisticamente menor que as cer?micas IPS Empress CAD (1169N/1240N) e IPS e.max CAD (1378N/1025N) (p<0,05). As cer?micas IPS Empress CAD e IPS e.max CAD n?o diferiram estatisticamente entre si (p>0,05). N?o houve diferen?a estat?stica na resist?ncia ? fratura sem e com ciclagem mec?nica para as cer?micas Mark II e IPS Empress CAD (p>0,05, teste t-student). Para a cer?mica IPS e.max CAD, a resist?ncia ? fratura sem ciclagem mec?nica foi estatisticamente superior ? obtida com ciclagem (p<0,05). As cer?micas IPS Empress CAD e IPS e.max CAD apresentaram maior resist?ncia ? fratura quando comparadas com a cer?mica Mark II. A ciclagem mec?nica influenciou negativamente apenas a cer?mica IPS e.max CAD.
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Castro, Márcia Gonçalves de. "Vigilância virológica dos vírus dengue: genotipagem e caracterização molecular de vírus isolados em mosquitos naturalmente infectados e humanos, 1986-2011." Instituto Oswaldo Cruz, 2012. https://www.arca.fiocruz.br/handle/icict/6933.
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Tese_Marcia de Doutorado DEFINITIVA - Para entregar no PGBP.pdf: 21978043 bytes, checksum: 1d029677a684e2e22915d3841a8206d3 (MD5)Made available in DSpace on 2013-09-17T16:29:26Z (GMT). No. of bitstreams: 1 Tese_Marcia de Doutorado DEFINITIVA - Para entregar no PGBP.pdf: 21978043 bytes, checksum: 1d029677a684e2e22915d3841a8206d3 (MD5) Previous issue date: 2012
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil
O dengue tem se apresentado como um grave problema de saúde pública no Brasil, razão pela qual, vários estudos têm sido realizados com o intuito de esclarecer aspectos da epidemiologia dessa doença em diferentes localidades, com histórias distintas de circulação dos diferentes sorotipos dos vírus dengue (DENV). A implantação de um Programa de vigilância entomológica e virológica e, que desde 1986 visa detectar e monitorar a circulação dos sorotipos e genótipos DENV, resultou em distintas oportunidades, no isolamento de amostras de DENV de vetores e de casos humanos permitindo a caracterização molecular e a análise filogenética, fornecendo informações relevantes para a compreensão da interação vetor- vírus- humanos. O entendimento da variação genética no vírus quando este replica em mosquitos, e como essas variações atuam durante a transmissão entre humanos e mosquitos permanecem desconhecidos. Portanto, visando contribuir para um melhor conhecimento dos DENV e sua interação com o mosquito vetor, realizamos neste trabalho, a caracterização molecular e análise filogenética de DENV isolados de mosquitos naturalmente infectados e de casos humanos, provenientes de epidemias ocorridas entre 1986 e 2011 no Brasil. Foi demonstrado que os métodos moleculares foram fundamentais por facilitarem a rápida identificação dos vírus e consequentemente o monitoramento dos genótipos circulantes. A RT-PCR para a triagem de DENV em vetores se mostrou uma ferramenta útil para a vigilância virológica, com taxas de detecção que variaram de 0,78% a 25% no período estudado. A análise filogenética dos DENV-1 isolados de mosquitos e humanos mostrou que o genótipo V (Américas/África) continua o mesmo circulante desde a sua introdução, porém foi demonstrada a co-circulação de duas novas linhagens (II e III) no período de 2009 a 2011. O sequenciamento do genoma completo de DENV-3 isolado a partir de Ae. aegypti naturalmente infectados no Rio de Janeiro (RJ), assim como a análise da região 3´NC de vírus isolados em mosquitos e humanos, caracterizou estes vírus como pertencentes ao GIII e revelou a presença de inserções e deleções na região 3´NC do genoma. As deleções observadas na região 3´NC resultaram em estruturas secundárias porém nem todas as cepas com inserções nesta região apresentaram estrutura similar substituições exclusivas à cepa de DENV-3 isolada em mosquito foram observadas no gene NS5, incluindo a substituição que resultou na formação de um códon de terminação. O teste comercial Simplexa™ Dengue Real Time RT-PCR, disponível recentemente, foi utilizado pela primeira vez para detecção dos DENV e se mostrou um método molecular alternativo para as vigilâncias entomológica e virológica. O RT-PCR em Tempo Real possibilitou, pela primeira vez, a quantificação de DENV-1 e DENV-4 em fêmeas individuais naturalmente infectadas (1,6 x 104 cópias/mL e 1,08 x 103 cópias/mL, respectivamente). Considerando-se o elevado índice de infestação por Ae. aegypti em todo o país, o estudo da caracterização dos DENV circulantes torna-se de grande importância no conhecimento da relação vírus-vetor pela análise da variabilidade genética, dispersão e persistência de genótipos durante a transmissão destes vírus
Dengue has been a major public health problem in Brazil with several studies performed aiming to elucidate the disease epidemiology in geographically distinct areas with different dengue viruses (DENV) circulation. The establishment of an entomological and virological program since 1986 with the objective of detecting and monitoring DENV serotypes and genotypes resulted in distinct opportunities in DENV isolation from vectors and human cases, allowing the molecular characterization and phylogenetic analysis, providing relevant information for the understanding of the vector-virus-humans interactions. The understanding of the virus genetic variability when it replicates on mosquitoes and how those variations act during the transmission between humans and mosquitoes is not fully understood. Therefore, aiming to contribute for a better understanding of DENV and its interactions with the mosquito vector, we performed in this study the molecular characterization and phylogenetic analysis of viruses isolated from naturally infected mosquitoes and human cases, from epidemics occurred between 1986 and 2011 in Brazil. It has been shown that the molecular techniques were essential for allowing the rapid identification of the viruses and consequently the monitoring of the circulating genotypes. The RT-PCR for DENV screening in vectors has shown to be a useful tool for the virological surveillance, with detection rates varying from 0.78% to 25% in the studied period. The phylogenetic analysis from DENV-1 isolated from mosquitoes and human cases showed that genptype V (America/Africa) is still the same genotype circulating since this serotype introduction, however it was demonstrated the co-circulation of two distinct new viral lineages (II and III) from 2009 to 2011. The complete genome sequencing of a DENV-3 isolated from naturally infected Ae. aegypti in Rio de Janeiro (RJ) and the analysis of the 3´UTR region from viruses isolated from mosquitoes and humans, has characterized those viruses as belonging to genotype III (GIII) and revealed the presence of insertions and deletions in the 3´UTR region of the genome. The deletions observed in the 3´UTR region resulted in similar secondary structures, however not all strains with insertions were similar in structure. Exclusive substitutions to the DENV-3 isolated from the mosquitoes were observed in NS5, including a substitution leading to a stop codon formation. The Simplexa™ Dengue Real Time RT-PCR commercial kit, recently available, was used for the first time for DENV detection and it has been shown to be an alternative molecular method for the entomological and virological surveillances, The Real Time RT-PCR has allowed, for the first time the DENV-1 and DENV-4 quantification in single Ae. aegypti naturally infected (1.6 x 104 copies/mL e 1.08 x 103 copies/mL, respectively). Considering the high Ae. aegypti infestation index in the country, the characterization of DENV circulating is very relevant for the understanding of the virus-vector relations by the analysis of the genetic variability, spread and persistence of genotypes during the transmission of those viruses
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Švorcová, Petra. "Výskyt extrémních teplot a jejich vliv na výnosové parametry zeleniny v ČR." Master's thesis, Česká zemědělská univerzita v Praze, 2017. http://www.nusl.cz/ntk/nusl-315901.
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The thesis is focused to the occurrence of extreme temperatures in the Czech Republic and monitors their effect on the yield of vegetables. The aim is to prepare a review of literature on the impact of extreme weather conditions on yield and quality of selected vegetables. The thesis is focused on the cultivation of vegetables grown for fruit, namely tomato (Lycopersicon esculentum). Besides meteorological effect they are also taken into consideration environmental conditions, crop rotation, effect of diseases and pests. It is also briefly described growing vegetables, history and specific characteristics of tomato.
The research was carried out on areas of the Elbe and the South Moravian vegetable growing region, they are in the Czech Republic for the cultivation of tomato in terms of temperature and favorable natural conditions perfect. For this study, yield data from 1977 to 2015 for the Czech Republic and Central Bohemia has been used. The relationship between yield of tomato and extreme meteorological indices was investigated. It was prepared by descriptive statistics and trend equations yields of tomatoes in the period, together with variations that are designed after pentads and it was created correlation coefficient with range of favorability or unfavourableness individual indices at different growing seasons phonological phases of tomato to its yield. According to the classification of the correlation coefficient is seen that due to the number of dry days of July were both observed area yields were reduced by 41%. It follows that not only extreme temperatures but also reduce rainfall adversely affect tomato yields. As results, we can mentioned that the proceeds of tomatoes are largely influenced not only by the high temperatures and the subsequent drought, as well as heavy rainfall and floods. Based on the results of this study can be confirmed that the extreme temperatures occurring in our vegetable growing region have on the yield of tomatoes adverse effect.
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Florido, Marcelo Pedro. "Os Deni do Cuniuá: um estudo do parentesco." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/8/8134/tde-12022014-124744/.
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Esta tese consiste na etnografia dos Deni do rio Cuniuá, localizados no sudoeste do estado do Amazonas e falantes de uma língua da família linguística arawá. Esta parte da população Deni vive em um relativo isolamento frente à sociedade brasileira, num cenário que contrasta com o intenso contato que mantinham algumas décadas atrás. A situação atual é antes o resultado de fatores histórico, como a crise do extrativismo e a demarcação das Terras Indígenas na região, do que do desejo dos próprios indígenas. A abordagem adotada coloca em primeiro plano o parentesco Deni, tomado como fio condutor e não como limite da análise. Abordando algumas temáticas da cosmologia deni, como a questão dos brancos, dos coletivos, da relação com os animais, da noção de pessoa, do casamento e dos vínculos de filiação, mostramos como o parentesco, longe de ser um domínio isolado, está relacionado com vários outros elementos do mundo. Realizamos aqui um exercício baseado em uma metodologia experimental para o estudo de genealogias, demonstrando como alguns aspectos do cosmos Deni influenciam suas práticas matrimoniais.This thesis is an ethnographic account of the Deni people, who live on the River Cuniuá at the Southwest corner of the Amazonas State and speak a language that belongs to the arawan family. This part of the Deni population currently lives in relative isolation from Brazilian society, which contrasts with the intense contacts of a few decades ago. The current situation is a direct result of historical factors such as the crisis of the extraction industry and the demarcation of native-land, and not the Denis own desire. The approach adopted by the present work focuses on, but is not limited by, Deni kinship. It addresses some elements of Deni cosmology, such as their relations with the whites, the nominated groups, the animals, as well as their conception of personhood, marriage and filiation, and demonstrates the manner in which kinship relates to several other elements of the their world. The present work conducts an exercise based on an experimental methodology for studies of genealogy, thus demonstrating how some aspects of the Deni cosmos play an influence on their marriage practices.
Books on the topic "Denʹ"
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Kopytin, Ėduard. Denʹ trinadt︠s︡atyĭ: (denʹ pervyĭ, denʹ posledniĭ). Moskva: Ė.RA, 2015.
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Amnuėlʹ, P. R. Denʹ posledniĭ--denʹ pervyĭ. Moskva: RUSSLIT, 1993.
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Kiselev, Viktor Pavlovich. Denʹ vcherashniĭ, denʹ nyneshniĭ. Nizhniĭ Novgorod: Volgo-Vi︠a︡tskoe kn. izd-vo, 1991.
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Kostyleva, Elena. Denʹ. Sankt-Peterburg: Pori︠a︡dok slov, 2019.
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Petukhov, I͡Uriĭ. Denʹ vcherashniĭ, denʹ zavtrashniĭ: Povesti, rasskazy. Moskva: "Sovremennik", 1989.
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T͡Sukasov, S. V. Denʹ pervyĭ--denʹ posledniĭ: Pami͡atʹ o voĭne. Moskva: "Sov. Rossii͡a", 1988.
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Gafni, Mordekhaĭ. Denʹ nezavisimosti. [Jerusalem]: Ministerstvo absorbt︠s︡ii Izraili︠a︡, Otdel spet︠s︡ialʹnoĭ absorbt︠s︡ii, 1992.
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Gaĭkalova, Anna. Denʹ devi︠a︡tyĭ. Moskva: Art Khaus Media, 2010.
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Minchkovskiĭ, Arkadiĭ. Denʹ zhizni. Moskva: "Sov. Rossii͡a︡", 1985.
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Abdullaev, Chingiz. Denʹ gneva. Moskva: Izd-vo "AST", 2002.
Find full textBook chapters on the topic "Denʹ"
1
Dumke, Hartmut, Tatjana Fischer, Michael Getzner, and Gernot Stöglehner. "Kapitel 7. Raumplanung und Klimawandel." In APCC Special Report: Landnutzung und Klimawandel in Österreich, 381–405. Berlin, Heidelberg: Springer Berlin Heidelberg, 2024. http://dx.doi.org/10.1007/978-3-662-67864-0_9.
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ZusammenfassungDas Ziel dieses Kap. 7 erfüllt eine wichtige Forderung aus dem letzten Klimawandelsachstandsbericht – nämlich, intensiv zu den Zusammenhängen zwischen Raumplanung und Klimawandel zu berichten. Denn die klimapolitisch bedenkliche Zunahme versiegelter Flächen in Österreich, die von den Expert_innen (z. B. Schindegger, 2020; Umweltbundesamt, 2020a) mit großer Sicherheit und empirischen Nachweisen festgestellt wird, ist derzeit eindeutig nicht im Einklang mit den Nachhaltigkeitszielen der österreichischen Bundesregierung (BMLFUW, 2002).
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Schu, Cornelia. "Globale Migration und Zusammenhalt diverser Gesellschaften." In X-Texte zu Kultur und Gesellschaft, 149–56. Bielefeld, Germany: transcript Verlag, 2022. http://dx.doi.org/10.14361/9783839463192-017.
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Cornelia Schu gibt fünf Antworten auf die Frage, wie man gelingende Integration politisch gestalten und den gesellschaftlichen Zusammenhalt stärken kann. Denn die gesellschaftliche Zustimmung zu Migration und Integration wächst.
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Momberger, Cathérine, and Rabea Bieckmann. "Soziales Spannungsfeld Rheinisches Revier - Einstellungen und öffentliche Diskussionen zur Energiewende." In Soziale Bewegung und Protest, 217–34. Bielefeld, Germany: transcript Verlag, 2022. http://dx.doi.org/10.14361/9783839463000-012.
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Cathérine Momberger und Rabea Bieckmann widmen sich in diesem Beitrag dem Braunkohleausstieg im Rheinischen Revier. Denn der Braunkohleausstieg in Deutschland bedeutet einen enormen Strukturwandel in den verbliebenen Braunkohlerevieren. Insbesondere im Rheinischen Braunkohlerevier werden immer wieder Konflikte um die Reichweite und den Tiefgang von Veränderungen zu mehr Klimaschutz und dem Braunkohleausstieg offensichtlich. In dem Beitrag werden Konfliktlinien und Äußerungen um den Braunkohleausstieg in den Blick genommen. Dabei werden quantitative Befragungsdaten und Online Kommentare betrachtet. Es kann festgehalten werden, dass von den vorherrschenden medialen Online-Debatten zu bestimmten Themen nur sehr eingeschränkt auf die Wahrnehmung derselben Themen durch die Bürger:innen in betroffenen Regionen geschlossen werden kann.
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Wild, Jochen. "Numerikbezogene Definitionen, Entwicklungen und Betrachtungen." In Optimierung der Tragfähigkeit von Zahnwellenverbindungen, 106–62. Wiesbaden: Springer Fachmedien Wiesbaden, 2022. http://dx.doi.org/10.1007/978-3-658-36961-3_4.
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ZusammenfassungUm für evolventisch basierte Zahnwellenverbindungen nach Kapitel 3.3, wenn denn existent, geometrieparameterspezifische Optima für das Kriterium der Gestaltfestigkeit bestimmen beziehungsweise, wenn denn nicht existent, Empfehlungen für ihre günstige Gestaltung definieren zu können, ist die Ermittlung der entsprechenden Festigkeit zahlreicher derartiger Verbindungen Grundvoraussetzung. Mit den in diesem Zusammenhang festgelegten Parameterfeldern, vgl. die Kapitel 4.3.1, 6.2.2 sowie 6.3.2, kann der zu bewältigende enorme Arbeitsaufwand grob abgeschätzt werden. Nicht angeführt sind hierbei weitere mannigfaltige Voruntersuchungen.
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Janßen, Melike, Uwe Schimank, and Ariadne Sondermann. "Zwischen Traditionsbewahrung und Modernisierungsbereitschaft: Professorale Ansprüche an Lehre und Forschung." In Hochschulreformen, Leistungsbewertungen und berufliche Identität von Professor*innen, 113–61. Wiesbaden: Springer Fachmedien Wiesbaden, 2021. http://dx.doi.org/10.1007/978-3-658-33289-1_3.
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ZusammenfassungIn diesem Kapitel beginnt die Interviewauswertung. Es geht zunächst darum, Vorstellungen der ProfessorInnen darüber herauszuarbeiten, was ‚gute‘ Lehre und Forschung jeweils ausmacht. Denn diese Vorstellungen sind als Identitätskomponenten der Maßstab, anhand dessen die von den Reformvorhaben hervorgebrachten Strukturveränderungen, insbesondere die mit Leistungsbewertungen verbundenen, beurteilt werden. Bereits hier werden, bei vielen Gemeinsamkeiten der meisten Befragten, Unterschiede zwischen den Wissenschaftsgebieten sowie zwischen den Karrierestufen erkennbar. Deutlich wird aber auch bereits, dass die im Mediendiskurs über die Hochschulreformen dominierende journalistische Darstellung von ProfessorInnen als Besitzstandswahrern und nur an Forschung Interessierten ein Zerrbild zeichnet.
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Straub, Sarah, Iris Baumgardt, and Dirk Lange. "Conclusio." In Berufs- und Arbeitswelt in der politischen Bildung, 165–66. Wiesbaden: Springer Fachmedien Wiesbaden, 2021. http://dx.doi.org/10.1007/978-3-658-34304-0_5.
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ZusammenfassungDie empirische Studie zeigt, dass das soziale Umfeld den größten Einfluss auf Bildungs- und Berufsaspirationen hat. Als Berufsorientierungsmaßnahme steht die Praxiserfahrung im Mittelpunkt, denn Vorbilder und Erfahrungsberichte aus der Praxis werden von den Viertklässler*innen der Sek I in Wien als ausschlaggebend für die Berufswahl betrachtet. Eine subjektorientierte Berufsorientierung in der Pflichtschule, die den individuellen Lernprozess der Schüler*innen berücksichtigt, wird als richtungsweisend für künftige didaktische Überlegungen und eine Ausrichtung der Berufsorientierung gesehen. Die Berufsorientierung nimmt dabei eine wichtige Rolle innerhalb der politischen Bildung ein, da sie die Grundlage für eine aktive Teilhabe am sozialen und ökonomischen Leben darstellt.
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Walter, Stefanie. "Ausgangslage: Energie- und Rohstoffwirtschaft im Spannungsfeld von gesellschaftlicher Notwendigkeit und bürgerschaftlichem Protest." In Akzeptanzkommunikation in der Energie- und Rohstoffwirtschaft, 1–5. Wiesbaden: Springer Fachmedien Wiesbaden, 2023. http://dx.doi.org/10.1007/978-3-658-40798-8_1.
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Zusammenfassung„KIES IST MIES“ (NEIN zum Sand- und Kiesabbau in Königshain, Claußnitz & Altmittweida, 2020b), „REST IN KIES“ (ebd.) und „Bei uns ist KEIN KIES zu holen!“ (NEIN zum Sand- und Kiesabbau in Königshain, Claußnitz & Altmittweida, 2020a) – diese Slogans sind auf Plakaten und Schildern in und um Altmittweida zu lesen: Bürger:innen engagieren sich gegen den seit 20 Jahren in Planung befindlichen Sand- und Kiesabbau vor Ort. Teile der mittelsächsischen Bevölkerung positionieren sich gegen den Rohstoffabbau, gegen fossile Energieumwandlung oder den Bau erneuerbarer Energieumwandlungsanlagen in ihrem Umfeld. Auf regionaler Ebene ist bürgerschaftlicher Widerstand eher Normalfall denn Ausnahme (Rugenstein, 2017).
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Rheinberger, Hans-Jörg. "Spotlight: Die Metaphernwelt der Molekularbiologie und molekularen Medizin." In Gen- und Zelltherapie 2.023 - Forschung, klinische Anwendung und Gesellschaft, 307–15. Berlin, Heidelberg: Springer Berlin Heidelberg, 2023. http://dx.doi.org/10.1007/978-3-662-67908-1_21.
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ZusammenfassungIch möchte diesen Zwischenruf dazu nutzen, ein wenig grundsätzlicher auf die Metaphernwelt der molekularen Biologie und Medizin sowohl im Wissenschaftsbereich als auch in den Medien einzugehen, denn beide sind nicht scharf voneinander zu trennen. Im Anschluss daran werde ich diese Überlegungen anhand von CRISPR/Cas exemplifizieren.
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Jaehrling, Karen, and Christin Stiehm. "Sozialpolitisierung: Der Einzug von sozialen Kriterien ins Vergaberecht." In Der Staat als ‚Guter Auftraggeber‘? Öffentliche Auftragsvergabe zwischen Vermarktlichung und Sozialpolitisierung, 71–132. Wiesbaden: Springer Fachmedien Wiesbaden, 2022. http://dx.doi.org/10.1007/978-3-658-38026-7_4.
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ZusammenfassungNahezu zeitgleich zum Beginn der Vermarktlichung hat auch das Ringen um den Stellenwert sozialer und anderer ‚vergabefremder‘ Ziele eingesetzt. Diese ‚Sozialpolitisierung‘ erfolgt im Modus der Politisierung – also gestützt auf Verfahren, Akteure und Ziel-Programme des politischen Systems. Im Ergebnis öffnen die jüngsten Gesetzesreformen und Gerichtsurteile auf europäischer Ebene die öffentliche Auftragsvergabe mehr denn je für soziale Zwecke, heben den Konflikt zwischen Wettbewerbsschutz und sozialen Zielen allerdings nicht auf. Vielmehr ist es hier gewissermaßen zu einer Institutionalisierung des Nebeneinanders von Vermarktlichung und Sozialpolitisierung gekommen.
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Egbert, Simon. "Drogentests als scripted technology." In Diskurs und Materialität, 179–201. Wiesbaden: Springer Fachmedien Wiesbaden, 2022. http://dx.doi.org/10.1007/978-3-658-37053-4_6.
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ZusammenfassungNachdem im vorangegangenen Kapitel die hinter Drogentestanwendungen am Arbeitsplatz stehenden Sicherheitsdiskurse dargelegt wurden, richtet sich der Blick ab jetzt stärker auf die Drogentests selbst. Denn Drogentesten ist nicht gleich Drogentesten. Es gibt unterschiedliche Wege, den Drogenkonsum von Personen zu überprüfen, womit jeweils unterschiedliche Aussagewerte und -wertigkeiten verbunden sind.
Conference papers on the topic "Denʹ"
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Schaupeter, Lars, and Matthias Vette-Steinkamp. "Geschlossener Informationsfluss über den gesamten Produktlebenszyklus als Wegbereiter zur effizienten Refabrikation." In 18. AALE-Konferenz. Hochschule für Technik, Wirtschaft und Kultur Leipzig, 2022. http://dx.doi.org/10.33968/2022.17.
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Die Refabrikation wird eine entscheidende Rolle zur Erreichung einer Kreislaufwirtschaft einnehmen, denn durch diesen Prozess können bereits ausgediente Produkte wieder in einen neuwertigen Zustand gebracht und dem Markt erneut hinzugefügt werden. Dennoch steht die Refabrikation vor Hindernissen, welche überwunden werden müssen. Dieser Beitrag soll einen Überblick über die Herausforderungen geben und den Stand der Technik erörtern, wie ein durchgängiger und geschlossener Informationsfluss über den gesamten Produktlebenszyklus einen wichtigen Beitrag zur Lösung dieser Hindernisse liefern kann.
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Schmitt, Michael, Ralf Casperson, Franziska Baensch, and Daniel Müller. "Nationale, europäische und internationale Normung in der zerstörungsfreien Prüfung." In DGZfP-Jahrestagung 2024. Deutsche Gesellschaft für Zerstörungsfreie Prüfung, 2024. http://dx.doi.org/10.58286/29496.
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Normung und Standardisierung in der zerstörungsfreien Prüfung finden auf nationaler, europäischer und internationaler Ebene statt. Die Übernahme von Leitungsfunktionen in diesen Gremien erzeugt die Möglichkeit der Steuerung von Themen und Inhalte der relevanten Normen. Das persönliche Engagement der Fachexpert*innen in den nationalen Gremien und den europäischen und internationalen Arbeitsgruppen ist ein zusätzlicher Faktor für die inhaltliche Korrektheit und die erwünschte inhaltliche Ausrichtung der Norm. Denn wer nicht normt wird genormt und muss letztlich Regeln verwenden, die andere entsprechend ihrer eigenen Interessen gestalten. Voraussetzung für die Teilnahme in europäischen und internationalen Normungsgremien ist die Mitwirkung in den entsprechenden DIN-Spiegelgremien, welche die europäischen (CEN) und internationalen (ISO) Aktivitäten spiegeln und die Fachexperten für die Mitarbeit autorisieren. Auf internationaler Ebene findet die Normungsarbeit in den technischen Komitees ISO/TC 135 “Non-destructive testing” und ISO/TC 44/SC 5 “Testing and inspection of welds” und ihren Arbeitsgruppen statt. Das europäische Pendant ist das CEN/TC 138 “Zerstörungsfreie Prüfverfahren” mit seinen Arbeitsgremien. Die DIN-Spiegelgremien sind für die deutsche Mitarbeit in diesen Gremien und die inhaltliche Bewertung der Norm-Entwürfe zuständig.
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Burg, Vanessa, Gillianne Bowman, and Oliver Thees. "optimierBAR: Mist und wieso er zur Sprache kommen muss. Hofdünger-Vergärung in der Schweiz: Energetisches Potenzial, reduzierte Treibhausgasemissionen und Grundeinstellung der Landwirte." In Forum für Wissen 2019: Schweiz erneuerbar! Swiss Federal Institute for Forest, Snow and Landscape Research, WSL, 2019. http://dx.doi.org/10.55419/wsl:21925.
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Hofdünger fällt bei der Tierhaltung in der Landwirtschaft an. Er liefert einerseits Nährstoffe für die Produktion von Nahrungsmitteln auf den Kulturlandflächen. Andererseits ist er ein potenzielles Biogassubstrat. Heute wird aus Hofdünger in der Schweiz noch kaum Energie erzeugt. Ein wichtiger Grund dafür sind ungenügende Anreize, vor allem ökonomischer Art. Das wachsende Bewusstsein für den Klimawandel und die Nutzung erneuerbarer Energien machen das riesige, ungenutzte Potenzial von Hofdünger jedoch attraktiver, insbesondere für die Biogaserzeugung durch Vergärung. Vor diesem Hintergrund analysierten wir unter Berücksichtigung der räumlichen Verteilung des Hofdüngers in der Schweiz, wie viel Energie sich aus dieser Biomasse gewinnen lässt und ob sich dadurch die Emissionen von Treibhausgasen reduzieren liessen. Ausserdem wollten wir wissen, ob die Landwirte bereit sind, ihren Hofdünger zu vergären: Denn am Schluss sind es sie, die sich dafür oder dagegen entscheiden.
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Iles, Tinen L., Timothy G. Laske, David L. Garshelis, Lars Mattison, Brian Lee, Val Eisele, Erik Gaasedelen, and Paul A. Iaizzo. "Medtronic Reveal LINQ™ Devices Provide Better Understanding of Hibernation Physiology in the American Black Bear (Ursus Americanus)." In 2017 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/dmd2017-3498.
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The American black bear (Ursus americanus) has been called a metabolic marvel6. In northern Minnesota, where we have conducted long-term physiological and ecological studies of this species, bears may remain in their winter dens for 6 months or more without eating, drinking, urinating or defecating and yet lose very little muscle mass2. We also found that hibernating black bears elicit asystolic events of over 30 seconds and experience an exaggerated respiratory sinus arrhythmia2. In this previous work we employed Medtronic Reveal® XT devices that required us to visit the den and temporarily extract the bear (under anesthesia) to download the stored data.4 Here we describe Medtronic’s latest generation of Insertable Cardiac Monitor (ICM), the Reveal LINQ™, which enables continuous transmission of data via a relay station from the den site3. Black bear hibernation physiology remains of high interest because of the multiple potential applications to human medicine. ICMs have been used for nearly two decades by clinicians as a critical diagnostic tool to assess the nature of cardiac arrhythmias in humans. Such devices are primarily implanted subcutaneously to record electrocardiograms. The device size, battery life and transmission capabilities have evolved in recent years. The first devices were relatively large and a programmer was needed to retrieve information during each clinical (or in our case, den visit). These devices were programmed to capture cardiac incidents such as asystolic events, arrhythmias and tachycardias and apply algorithms that ensure proper data collection: e.g. ectopy rejection and p-wave presence algorithms. The new generation Reveal LINQ was made to telemetrically transmit heart data from human patients, but we needed to develop a system to enable transmission from bear dens, which are remote (cannot easily be checked and adjusted) and are subject to extreme winter weather conditions. Besides the advantage of these devices transmitting data automatically, they are considerably smaller and thus less prone to rejection by the extraordinary immune system of the hibernating bear1.
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Calañas Continente, José Antonio. "Mehrsprachige Autoren und Selbstübersetzung: ein erfahrungsbericht." In La Traducción y sus meandros: diversas aproximaciones en el par de lenguas alemán-español. Ediciones Universidad de Salamanca, 2022. http://dx.doi.org/10.14201/0aq0320139150.
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In der Regel geht man davon aus, ein literarischer Autor schreibe nur in der eigenen Muttersprache. Dieser Gedankengang verliert an Aussagekraft, wenn Autoren wie z.B. Franz Kafka, Anise Koltz oder Jorge Semprún in Betracht gezogen werden, denn sie haben entweder ausschließlich (Kafka) in der eigenen Kultursprache geschrieben, oder sie haben sich regelmäßig der jeweiligen Kultur- und Muttersprache bedient (Koltz, Semprún). In diesem Beitrag wird anhand eigener Texte gezeigt, wie Entscheidungen über den Übersetzungsprozess getroffen werden, wenn der Autor sich der Aufgabe stellt, die eigene Produktion für die Veröffentlichung in einer anderen Sprache vorzubereiten. Dabei wird auch darüber reflektiert, ob der Selbstübersetzungsprozess je nach Ausgangssprache variiert: syntaktische, lexikalische sowie rhetorische Abweichungen zwischen Sprachen werden aufgezeigt und erläutert. Als Fazit wird versucht, aufgrund der besprochenen Anmerkungen und Anregungen ein «Lastenheft» für die Übersetzung literarischer Texte zu präsentieren.
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Waser, Lars, and Christian Ginzler. "Landesweite Datensätze zum Wald mittels Fernerkundung - der Beginn einer neuen Ära." In Forum für Wissen 2023. Swiss Federal Institute for Forest, Snow and Landscape Research, WSL, 2023. http://dx.doi.org/10.55419/wsl:33059.
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Regelmässig erhobene, aktuelle Informationen zu verschiedenen Waldparametern auf landesweiter Ebene erfuhren in den letzten Jahren eine steigende praktische und wissenschaftliche Relevanz. Neueste Technologien aus der Fernerkundung und dem maschinellen Lernen haben eine neue Ära eingeläutet und ermöglichen eine genaue, reproduzierbare und flächige Erstellung der gewünschten Datensätze. Sie dienen als zuverlässige Basis zur Beschreibung des heutigen Zustandes sowie der zukünftigen Entwicklung des Waldes. Im folgenden Artikel werden die im Rahmen des Schweiz. Landesforstinventars (LFI) landesweit verfügbaren Datensätze Vegetationshöhenmodell, Waldmischungsgrad, Gebüschwald und Holzvorrat vorgestellt. Es wird aufgezeigt, was heutzutage mit Fernerkundungs- und Modellierungstechniken möglich ist und wo aber auch die Grenzen liegen. Neben einer kurzen Beschreibung der verschiedenen Datensätze, wird ein spezielles Augenmerk auf die Interpretation der Resultate und deren Anwendung gelegt. Anhand des Waldmischungsgrads LFI wird der Unterschied zwischen Modellgenauigkeit und Produktegenauigkeit erklärt. Ein wichtiger Punkt ist die korrekte und solide Validierung, mit unabhängigen Daten und auch Vor-Ort-Begehungen. Zudem wird aufgezeigt, dass ein Austausch zwischen der Praxis und Forschung wichtiger denn je ist.
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Zhu, Xian-Kui, and Rick Wang. "Effect of Residual Stress or Plastic Deformation History on Fatigue Life Simulation of Pipeline Dents." In 2018 12th International Pipeline Conference. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/ipc2018-78805.
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Mechanical dents often occur in transmission pipelines, and are recognized as one of major threats to pipeline integrity because of the potential fatigue failure due to cyclic pressures. With matured in-line-inspection (ILI) technology, mechanical dents can be identified from the ILI runs. Based on ILI measured dent profiles, finite element analysis (FEA) is commonly used to simulate stresses and strains in a dent, and to predict fatigue life of the dented pipeline. However, the dent profile defined by ILI data is a purely geometric shape without residual stresses nor plastic deformation history, and is different from its actual dent that contains residual stresses/strains due to dent creation and re-rounding. As a result, the FEA results of an ILI dent may not represent those of the actual dent, and may lead to inaccurate or incorrect results. To investigate the effect of residual stress or plastic deformation history on mechanics responses and fatigue life of an actual dent, three dent models are considered in this paper: (a) a true dent with residual stresses and dent formation history, (b) a purely geometric dent having the true dent profile with all stress/strain history removed from it, and (c) a purely geometric dent having an ILI defined dent profile with all stress/strain history removed from it. Using a three-dimensional FEA model, those three dents are simulated in the elastic-plastic conditions. The FEA results showed that the two geometric dents determine significantly different stresses and strains in comparison to those in the true dent, and overpredict the fatigue life or burst pressure of the true dent. On this basis, suggestions are made on how to use the ILI data to predict the dent fatigue life.
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Dinovitzer, A., R. Lazor, L. B. Carroll, J. Zhou, F. McCarver, S. Ironside, D. Raghu, and K. Keith. "Geometric Dent Characterization." In 2002 4th International Pipeline Conference. ASMEDC, 2002. http://dx.doi.org/10.1115/ipc2002-27076.
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The Canadian pipeline design standard (CSA Z662) requires the repair of smooth dents with depths exceeding 6% of the pipeline’s outside diameter. This limit on dent depth is reduced in the presence of additional localized effects such as pipe wall gouges, corrosion, planar flaws or weld seams. It has been noted, however, that pipelines have operated satisfactorily with dents in excess of 10% while others with 3% dents have failed. Based upon observation of this type the question arises, “Is there more to characterizing a dent than its depth?” An ongoing group sponsored project at BMT Fleet Technology Limited (FTL) is exploring the issue of dent characterization using a dent assessment model developed at FTL. The objective of this project is to develop a rapid dent life expectancy characterization technique based upon dent geometry, line pressure history and line pipe material properties. This paper will outline the general characterization approach being considered and demonstrate some of the observed and expected relationships between service life and dent geometry. The relative importance of each dent characteristic (geometric measures, line pipe material and line pressure history) will be discussed to demonstrate the potential of the rapid characterization approach being developed.
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McCoy, Jackie, and Scott Ironside. "Dent Management Program." In 2004 International Pipeline Conference. ASMEDC, 2004. http://dx.doi.org/10.1115/ipc2004-0393.
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Enbridge Pipelines Inc. owns and operates the world’s longest hydrocarbon transmission system, which traverses across the varying geophysical landforms of Canada and the United States. These pipelines range in diameter from 12” to 48” and were constructed between 1950 and 2003. The wide range of pipe sizes, practices used for construction, and landforms traversed result in a very challenging Dent Management Program. Standards such as CSA Z662-99, ASME B31.4, and B31.8 provide a criterion for the selection of dents that require repair. Experience has shown that these standards do not identify all dents that have a possibility of failure due to leak or rupture. Enbridge initiated a project to study dents with BMT Fleet Technology of Kanata Ontario, this study determined that the dent geometry in addition to the depth to pipe diameter ratio affects the propensity that a dent will fail. Recent research and development by a group sponsored project lead by BMT Fleet technology on dent characterization has combined the pipeline’s cyclic pressure history with the shape of the dent to predict a time to failure. Enbridge combines these tools along with new insights from field excavations into its Dent Management Program. The Dent Management Program includes a series of prioritization’s to determine which sections of pipelines require detailed dent analysis. Typical prioritization criteria are rocky terrain, larger occurrence of third party damage, and history of numerous dents or failures. The detailed analysis utilizes the BMT Fleet “Dent Characterization Criteria” which was developed using their Finite Element Dent Assessment Model. This model considers the geometry of the dent, pipe material properties and historical pressure data to predict a time to failure for each dent. This time to failure prediction requires some additional engineering analysis depending on how close the parameters of the actual pipe are to what was validated with the model. This engineering analysis will determine which dents are selected for excavation and examination. This model has provided Enbridge with a tool to better manage its dent program, and this will be proposed as an option to improve the existing standards.
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Tiku, Sanjay, Amin Eshraghi, Vlad Semiga, Luis Torres, and Mark Piazza. "Improved Pipeline Dent Integrity Management." In 2016 11th International Pipeline Conference. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/ipc2016-64530.
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Pipeline dents can be developed from the pipe resting on rock, a third party machinery strike, rock strikes during backfilling, amongst other causes. The long-term integrity of a dented pipeline segment depends upon parameters including pipe geometry, indenter shape, dent depth, indenter support, secondary features, and pipeline operating pressure history at and following indentation. US DoT and other standards include dent repair and remediation criteria broadly based upon dent depth, dent location (top or bottom side), pressure cycling (liquid or gas), and dent interaction with secondary features (weld, corrosion, cracks). These criteria are simple and easily applied, however, they may not direct maintenance appropriately and be overly conservative or, in some cases, unconservative. Previous IPC papers have discussed the full-scale dent fatigue testing and dent modelling efforts to support integrity management criteria development by collecting material and structural response during dent formation and pressure loading. The present paper will present the results of this extensive dent structural and fatigue life numerical simulation program using a validated finite element (FE) analysis process. The paper describes the numerical simulation technique, as well as, the development of the novel engineering tool for integrity management, eliminating the need for numerical simulation of individual dent features to assess the relative integrity threat they pose. The development of the engineering tool presented in this paper considers the dent formation, re-rounding and through life response to pressure fluctuations to evaluate the fatigue life of dent features. The results of these analyses are used to develop fatigue life trends based on dent shape, restraint condition and operating pressure. These trends were used to develop models to predict dent relative severity and life based upon ILI inspection dent shape data for single peak dents. Dent shape has also been used to determine the restraint condition of a dent and its influence on the dent feature fatigue life. The tools were developed to address many of the uncertainties inherent in existing regulatory repair and remediation criteria. Current and future applications of the integrity assessment model are described along with recommendations for further development and testing to support pipeline integrity management, industry guidelines and standards. The results of this research will be of use in improving integrity management decisions and support further development of industry guides and standards. As such the information presented in this paper will be of interest to pipeline operators, integrity management specialists, in-line inspection (ILI) organizations and regulators. The recommendations presented in this paper may be used to influence the direction of pipeline standards in their direction in the disposition of dent features.
Reports on the topic "Denʹ"
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von Balthasar, Hans Urs. Über den Gehorsam in den Weltgemeinschaften. Saint John Publications, 2024. http://dx.doi.org/10.56154/px.
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Kamp, Bart, Francisco Carrillo, and Francesco Pescarin. Euskal ekonomiako eta enpresetako atzerriko zuzeneko inbertsioaren analisia eta lehiarkortasunean duen eraginaren balioespena. Edited by Patricia Canto. Universidad de Deusto, 2024. http://dx.doi.org/10.18543/frjr6381.
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Atzerriko zuzeneko inbertsioa (AZI), bai herrialdera sartzen dena eta bai herrialdetik ateratzen dena, garrantzi handikoa da herrialde baten ekonomiarako, hazkunde ekonomikoa lortzen, enplegua sortzen, teknologia transferitzen eta mugaz haraindiko balio kateetan eta nazioarteko espazio ekonomikoetan integratzen laguntzen duelako. Hori jakinik, “Euskal ekonomiako eta bertako enpresetako atzerriko zuzeneko inbertsioaren analisia” txostenak Euskal Autonomia Erkidegora sartzen den eta bertatik ateratzen den zuzeneko inbertsioa ditu aztergai. Horretarako, 2014-2021 aldiko datu agregatuak erabili ditu eta atzerriko entitateek eskuratu zituzten euskal enpresa batzuen kasuak aztertu ditu. Amaitzeko, policy makerrentzat zenbait gomendio ematen dira, herrialdera sartzen den atzerriko zuzeneko inbertsioan eragina duten elementuei buruz.
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Rao, C. R., and D. N. Shanbhag. Further Extensions of the Choquet-Deny and Deny Theorems with Applications in Characterization Theory. Fort Belvoir, VA: Defense Technical Information Center, August 1987. http://dx.doi.org/10.21236/ada193358.
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Keihauer, Silke, Martin Führ, and Julian Schenten. Marktchancen für "nachhaltigere Chemie" durch die REACH-Verordnung - Am Beispiel globaler Lieferketten in der Textil- und Sportartikel-Industrie (SuSport). Sonderforschungsgruppe Institutionenanalyse, March 2019. http://dx.doi.org/10.46850/sofia.9783941627697.
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Dieser Bericht dokumentiert die Ergebnisse des Forschungsprojekts „Marktchancen für ‚nachhaltigere Chemie‘ durch die REACH-Verordnung [Sustainable Sporting Goods - SuSport]“. Ziel des im Jahr 2018 abgeschlossenen Projektes ist es, eine „nachhaltigere Chemie“ in der textilen Lieferkette zu unterstützen und dabei den Blick von der „reaktiven“ Compliance Position auf eine „proaktive“ Beyond Compliance Perspektive zu erweitern. Strategisch stützt sich dieser Ansatz auf folgende Überlegung: Wer morgen noch „Compliant“ sein will, muss heute bereits „Beyond Compliance“ agieren. Mit einer solchen Strategie ist nicht nur die Rechtskonformität gewährleistet, es lassen sich viel-mehr auch neue Marktchancen erschließen.4 Die Notwendigkeit für diesen Perspektivenwechsel ergibt sich bereits aus der normativen Ausgangssituation Ein solcher Perspektivenwechsel und die damit verbundenen Veränderungen bedeuten für die Akteure der Textilbranche eine große Herausforderung Denn letztlich führt dies zu der Frage, wie man ein Chemikalienmanagement in der globalen Lieferkette organisiert Aus diesem Kontext ergeben sich die Empfehlungen für die Akteure der textilen Lieferkette Methodisch bestand die Herausforderung darin, die vorherrschenden Denk- und Argumentationsmuster der beteiligten Akteure der textilen Kette für die Ziele dieses Vorhabens zu öffnen Es bleibt abzuwarten, ob der entstandene Prozess ein Momentum erzeugt, der zu den gewünschten Veränderungen in der textilen Lieferkette führt erste Schritte in diese Richtung sind aber bereits erkennbar.
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NMR Publicering. Behöver den nordiska modellen förändras? Nordisk Ministerråd, June 2014. http://dx.doi.org/10.6027/anp2014-734.
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Clement, Werner, and M. Ajayi. Innovationen auf den Markt bringen. Rat für Forschung und Technologieentwicklung, December 2009. http://dx.doi.org/10.22163/fteval.2010.354.
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Riechman, Dennis J. Cyber Disrupt and Deny (Cyber D&D). Fort Belvoir, VA: Defense Technical Information Center, May 2010. http://dx.doi.org/10.21236/ada521206.
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Williams. L51671 Criteria for Dent Acceptability of Offshore Pipelines. Chantilly, Virginia: Pipeline Research Council International, Inc. (PRCI), July 1992. http://dx.doi.org/10.55274/r0010217.
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Extensive research has provided an understanding in the behavior of pipelines subjected to mechanical damage. The presence of a gouge or the combination of a gouge and a dent has been proven detrimental to the burst strength of pipelines. The research has also revealed that plain smooth dents, in the absence of a defect, do not significantly reduce the burst strength of pipelines. On the other hand, plain dents locally increase the pipe stress due to pressure. Thus, fatigue failures from dents can occur from normal operating pressure fluctuations in the lines over a period of time This report documents the testing and analysis work done to establish the effects of pipeline dents (without gouges) under cyclic internal pressure loading. The work consisted of several sub-tasks. First, operators were surveyed regarding the expected dent shapes and failures from dents that had been experienced. Secondly, a full scale test program utilizing 12-3/4" pipe was carried out. In this program eight pipes, each 20" long with diameter/thickness ratios of 18-50, were subjected to three dents each of various sizes and pressure cycled until failure or until 50,000 to 70,000 equivalent cycles of 0 - 1200 psi pressure was achieved. Next, elastic finite element analysis was utilized to determine the significance of dent shapes and lengths. Finally plastic finite element analysis was utilized to determine analytically the stress to pressure ratios so that a fatigue analysis could be done.
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Gönner, Anne Kathrin. Service für den Einstieg in den fremden Markt - Praktikum bei der deutschen Handelskammer für Spanien. Technische Hochschule Wildau, 2014. http://dx.doi.org/10.15771/2199-1618_2014_1_2_8.
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Smith, Peter. Overseas Aid in the Dragons' Den. Bristol, UK: The Economics Network, April 2010. http://dx.doi.org/10.53593/n1031a.
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