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1

Rodriguez, Moses, ed. Advances in multiple Sclerosis and Experimental Demyelinating Diseases. Berlin, Heidelberg: Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-73677-6.

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2

Satellite Symposium on Myelination and Demyelination: Implications for Multiple Sclerosis (1987 Vancouver, B.C.). Myelination and demyelination: Implications for multiple sclerosis. New York: Plenum Press, 1989.

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3

Demyelinating disorders of the central nervous system in childhood. Cambridge: Cambridge University Press, 2010.

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4

Rosner, Louis J. Multiple sclerosis. New York: Prentice Hall Press, 1987.

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5

Multiple sclerosis. London: Routledge, 1988.

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6

Gold, Susan Dudley. Multiple sclerosis. Parsippany, N.J: Crestwood House, 1997.

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7

Multiple sclerosis. Parsippany, N.J: Crestwood House, 1998.

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8

Understanding multiple sclerosis. Jackson: University Press of Mississippi, 2006.

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9

Rudick, Richard A., and Jeffrey A. Cohen. Multiple sclerosis therapeutics. 4th ed. Cambridge: Cambridge University Press, 2011.

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10

Multiple sclerosis therapeutics. 4th ed. Cambridge: Cambridge University Press, 2011.

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11

Women living with multiple sclerosis. Alameda, CA: Hunter House Publishers, 1999.

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12

Saunders, Carol. What nurses know-- multiple sclerosis. New York: Demos Health, 2011.

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13

Saunders, Carol. What nurses know-- multiple sclerosis. New York: Demos Health, 2011.

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14

Miller, Aaron E. Multiple sclerosis in clinical practice. London: Martin Dunitz, 2003.

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15

D, Lublin Fred, and Coyle Patricia K, eds. Multiple sclerosis in clinical practice. London: Martin Dunitz, 2003.

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16

Samkoff, Lawrence M., and Andrew D. Goodman. Multiple sclerosis and CNS inflammatory disorders. Chichester, West Sussex, UK: John Wiley & Sons Inc., 2014.

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17

The clinical neuropsychiatry of multiple sclerosis. Cambridge, U.K: Cambridge University Press, 1999.

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18

Nichols, Judith Lynn. Living beyond multiple sclerosis: A women's guide. Alameda, CA: Hunter House, 2000.

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19

Gingold, Jeffrey N. Facing the cognitive challenges of multiple sclerosis. New York, N.Y: Demos Health, 2011.

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20

Gingold, Jeffrey N. Facing the cognitive challenges of multiple sclerosis. New York, NY: Demos Medical Pub., 2006.

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21

Holland, Nancy J. Multiple sclerosis: A guide for the newly diagnosed. 2nd ed. New York: Demos Vermande, 2002.

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22

Holland, Nancy J. Multiple sclerosis: A guide for the newly diagnosed. New York: Demos Vermande, 1996.

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23

Holland, Nancy J. Multiple sclerosis: A self-care guide to wellness. 2nd ed. New York: Demos, 2005.

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24

Murray, T. J. Multiple sclerosis: A guide for the newly diagnosed. 4th ed. New York, NY: Demos Health, 2012.

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25

Kennedy, Patricia. The can do multiple sclerosis guide to lifestyle empowerment. New York, NY: Demos Medical Pub., 2012.

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26

Richer, Catherine Balsdon. Occupational therapy practice guidelines for adults with neurodegenerative diseases: Multiple sclerosis, transverse myelitis, and amyotrophic lateral sclerosis. Bethesda, Md: American Occupational Therapy Association, 1999.

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27

Apel, Melanie Ann. Let's talk about living with a parent with multiple sclerosis. New York: Powerkids Press, 2001.

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28

Mackie, Carole. Me and my shadow: Learning to live with multiple sclerosis. London: Aurum, 1999.

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29

Going the distance: Living a full life with multiple sclerosis and other debilitating diseases. New York: Dutton, 1989.

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30

service), ScienceDirect (Online, ed. Neuroinflammation. Amsterdam: North Holland, 2010.

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31

Coyle, Patricia K. Living with progressive mulitple sclerosis: Overcoming the challenges. 2nd ed. New York, NY: Demos Medical Pub., 2008.

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32

Shelley, Ross, ed. Multiple sclerosis: New hope and practical advice for people with MS and their families. New York: Simon & Schuster, 1992.

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33

Rosner, Louis J. Multiple sclerosis: New hope and practical advice for people with MS and their families. New York: Fireside Book, 2008.

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34

1936-, Bennett Hal Zina, ed. You are not your illness: Seven principles for meeting the challenge. New York: Simon & Schuster, 1995.

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35

Fife, Bruce. Stop Alzheimer's now!: How to prevent and reverse dementia, Parkinson's, ALS, multiple sclerosis, and other neurodegenerative disorders. Colorado Springs, CO: Piccadilly Books, 2011.

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36

S, Freedman Mark, ed. Multiple sclerosis and demyelinating diseases. Philadelphia: Lippincott Williams & Wilkins, 2006.

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37

Multiple Sclerosis and Demyelinating Diseases (Advances in Neurology). Lippincott Williams & Wilkins, 2005.

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38

Compston, Alastair. Multiple sclerosis and other demyelinating diseases. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198569381.003.0871.

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The oligodendrocyte–myelin unit subserves saltatory conduction of the nerve impulse in the healthy central nervous system. At one time, many disease processes were thought exclusively to target the structure and function of myelin. Therefore, they were designated ‘demyelinating diseases’. But recent analyses, based mainly on pathological and imaging studies, (re)emphasize that axons are also directly involved in these disorders during both the acute and chronic phases. Another ambiguity is the extent to which these are inflammatory conditions. Here, distinctions should be made between inflammation, as a generic process, and autoimmunity in which rather a specific set of aetiological and mechanistic conditions pertain. And there are differences between disorders that are driven primarily by immune processes and those in which inflammation occurs in response to pre-existing tissue damage.With these provisos, the pathological processes of demyelination and associated axonal dysfunction often account for episodic neurological symptoms and signs referable to white matter tracts of the brain, optic nerves, or spinal cord when these occur in young people. This is the clinical context in which the possibility of ‘demyelinating disease’ is usually considered by physicians and, increasingly, the informed patient. Neurologists will, with appropriate cautions, also be prepared to diagnose demyelinating disease in older patients presenting with progressive symptoms implicating these same pathways even when there is no suggestive past history. Both in its typical and atypical forms multiple sclerosis remains by far the commonest demyelinating disease. But acute disseminated encephalomyelitis, the leucodystrophies, and central pontine myelinolysis also need to be considered in particular circumstances; and multiple sclerosis itself has a differential diagnosis in which the relapsing-remitting course is mimicked by conditions not associated with direct injury to the axon–glial unit. Since our understanding of the cause, pathogenesis and features of demyelinating disease remains incomplete, classification combines aspects of the aetiology, clinical features, pathology, and laboratory components. Whether the designation ‘multiple sclerosis’ encapsulates one or more conditions is now much debated. We anticipate that a major part of future studies in demyelinating disease will be further to resolve this question of disease heterogeneity leading to a new taxonomy based on mechanisms rather than clinical empiricism. But, for now, the variable ages of onset, unpredictable clinical course, protean clinical manifestations, and non-specific laboratory investigations continue to make demyelinating disease one of the more challenging diagnostic areas in clinical neurology.
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39

Kaplan, Tamara, and Tracey Milligan. Demyelinating Diseases 1: Multiple Sclerosis (DRAFT). Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190650261.003.0013.

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The video in this chapter explores demyelinating diseases, and focuses on multiple sclerosis (MS). It discusses the causes of MS, its etiology, symptoms (optic neuritis, sensory changes, weakness, spasticity, and bowel and bladder dysfunction), and subtypes (relapsing remitting (RRMS), secondary progressive (SPMS), and primary progressive (PPMS)).
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40

J, Vinken P., and Koetsier Johan C, eds. Demyelinating diseases. Amsterdam: Elsevier Science Publishers, 1985.

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41

Moses, Rodriguez, ed. Advances in multiple sclerosis and experimental demyelinating diseases. Berlin: Springer, 2008.

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42

Brochet, Bruno. Neuropsychiatric Symptoms of Inflammatory Demyelinating Diseases. Springer, 2015.

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43

Rodriguez, Moses. Advances in Multiple Sclerosis and Experimental Demyelinating Diseases. Springer, 2014.

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44

Misulis, Karl E., and E. Lee Murray. Demyelinating Diseases. Edited by Karl E. Misulis and E. Lee Murray. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190259419.003.0022.

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The hospital neurologist is often consulted to coordinate the evaluation and management of a host of known or suspected demyelinating diseases. Among the most common are multiple sclerosis, acute disseminated encephalomyelitis, optic neuritis, and transverse myelitis.
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45

Index of RCRA Regulatory Interpretations. Elsevier Science Ltd, 1996.

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46

Bhargava, Pavan, and Peter A. Calabresi. Multiple Sclerosis. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0087.

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Multiple sclerosis is a chronic demyelinating neurological disorder of the brain and spinal cord, with both inflammatory and degenerative components. Current treatment strategies utilize immunomodulatory and immunosuppressive agents to reduce the inflammatory disease activity and retard accumulation of disability. Future challenges for treatment include identifying agents that will promote remyelination and axonal protection to help impact progressive forms of multiple sclerosis. This chapter discusses currently available disease modifying therapies, agents currently in phase 2/3 trials, and future directions in the treatment of multiple sclerosis.
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47

Keegan, B. Mark. Common Pitfalls in Multiple Sclerosis and CNS Demyelinating Diseases: Case-Based Learning. Cambridge University Press, 2016.

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48

Tillema, Jan-Mendelt, J. Graves, L. A. Benson, G. S. Aaen, A. Belman, J. Parrish, B. Weinstock-Guttman, L. Krupp, T. Chitnis, and E. Wauban. Pediatric Multiple Sclerosis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199341016.003.0022.

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Increased interest in pediatric-onset multiple sclerosis (MS) has contributed to improved knowledge of the presentation and evolution of central nervous system demyelinating diseases in childhood. This chapter reviews the unique features and challenges related to pediatric MS. The close proximity of pediatric MS to the biological onset of the disease provides a unique window into disease pathogenesis at stages of life when innate and adaptive immune pathways are still maturing. It is expected that the interplay between genetics, epigenetics, environmental exposures, and the maturing central nervous system in children with MS will provide important insights into the earliest phases of the disease. This chapter reviews the unique features that distinguish pediatric patients with MS from their adult counterparts. Specific emphasis is placed on the work-up and management of these patients in the context of current knowledge.
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49

Guo, Yong, and Claudia F. Lucchinetti. Taking a Microscopic Look at Multiple Sclerosis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199341016.003.0005.

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The pathology of multiple sclerosis is complex, extends beyond the white matter plaque, and is influenced by stage of demyelinating activity, clinical course, disease duration, and treatment. Technological advances in immunology, molecular biology, and “omic” biology have provided novel insights into the mechanisms for development of white matter plaques, axonal damage, cortical demyelination, and disease progression. Detailed, systematic, and statistically rigorous pathological studies on clinically well-characterized MS cohorts have helped define the heterogeneous pathological substrates of MS and unravel the complex molecular pathogenic mechanisms, with the ultimate goal of identifying targets for therapeutic interventions. It is increasingly clear that the use of human tissues is imperative to improve current diagnostic, prognostic, and therapeutic modalities. Preclinical animal models have been invaluable for discovery of key immune processes, basic disease mechanisms, and candidate immune targeting strategies, but the conclusions have yet be reconciled with the essential features of the human disease.
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50

Kim, Seung U. Myelination and Demyelination: Implications for Multiple Sclerosis. Springer, 2011.

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