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Lee, Sun Young. "The Effect of Lavender Aromatherapy on Cognitive Function, Emotion, and Aggressive Behavior of Elderly with Demenita." Journal of Korean Academy of Nursing 35, no. 2 (2005): 303. http://dx.doi.org/10.4040/jkan.2005.35.2.303.
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Hall, Kathleen S., Jianzhao Shen, Sujuan Gao, Jill R. Murrell, Valerie Smith-Gamble, Adesola Ogunniyi, Frederick W. Unverzagt, and Hugh C. Hendrie. "O4-05-06: Prevalence rates for demenita and Alzheimer's disease in elderly African Americans in Indianapolis: 1992 vs 2001." Alzheimer's & Dementia 4 (July 2008): T195. http://dx.doi.org/10.1016/j.jalz.2008.05.541.
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Moreno Sáez, María del Carmen. "“Impresiones en azul”. La cianotipia como agente catalizador de la mejora psicosocial y fomento de la comunicación de las personas con demencia temprana." Comunitania. Revista Internacional de Trabajo Social y Ciencias Sociales, no. 14 (February 9, 2018): 27. http://dx.doi.org/10.5944/comunitania.14.2.
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“Impresiones en azul” se corresponde con el nombre genérico de varios talleres dentro de un programa de educación artística para personas con demencia temprana, realizados en el Centro de Referencia Estatal de Atención a Personas con Enfermedad de Alzheimer y otras Demencias, de Salamanca, dependiente del IMSERSO. El objetivo de este programa era evaluar si la implementación de actividades artísticas podía ser una estrategia eficaz para promover el bienestar y las capacidades psicosociales, cognitivas y de comunicación de las personas con demencia temprana y, en consecuencia, una manera de mejorar los sistemas de cuidado de los mayores con principios de demencia. Estos talleres consistieron en el desarrollo de una sencilla técnica fotográfica, combinada con nuevas tecnologías. La investigación psicosocial cualitativa fue la metodología utilizada, prevista en tres fases: diseño de las actividades, desarrollo y seguimiento de los mismos y análisis de las producciones artísticas de los asistentes. Las conclusiones a las que se han llegado se pueden resumir en las siguientes: la demencia no ha supuesto problema alguno para el desarrollo de los talleres, el interés demostrado por los pacientes ha sido significativo, obteniendo resultados positivos en relación con su bienestar psicosocial, se ha experimentado un incremento de la comunicación entre los asistentes, tanto en sus relaciones interpersonales, como en su proyección al exterior y, por último, merece la pena destacar los modelos que pueden ser desarrollados en el cuidado de las personas con demencia temprana.“Impressions in blue” is the generic name given to several workshops belonging to an Art Education program targeted to people with early dementia, carried out in the State Centre for the Attention to People with Alzheimer Disease and other Dementias, in Salamanca, dependent on the IMSERSO. The aim of this program was assessing if the implementation of artistic activities could be an efficient strategy for promoting wellbeing and psychosocial, cognitive and communication capacities in people with early dementias and, therefore, improve the caring systems for the elderly with early dementias. These workshops consisted on the development of a simple photographic technique, combined with new technologies. The psychosocial qualitative research was the chosen methodology and was organised in three phases: activities design, development, follow-up and analysis of the artistic productions done by the participants. The conclusions drawn can be outlined as follows: Dementia didn’t cause any problem while developing the workshops; the interest shown by the participants was remarkable, obtaining positive reactions in regard to their psycho-social wellbeing; it was observed an increase in communication amongst the participants, not only in their personal relationships but also in their contact with the outside; lastly, it is worth highlighting the models that can be developed in the early dementia care.
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Lautenschlager, Nicola T., and Ralph N. Martins. "Common versus uncommon causes of dementia." International Psychogeriatrics 17, s1 (September 2005): S27—S34. http://dx.doi.org/10.1017/s1041610205002000.
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When patients present with a dementia syndrome at a young age, the experienced clinician will automatically include uncommon dementias in the diagnostic considerations, as familial uncommon dementias due to genetic mutations frequently present as early-onset dementias. This paper highlights why uncommon dementias due to genetic mutations, although marginal in terms of prevalence numbers in the total population, are of significance in the quest to unravel the underlying cause of common dementias such as Alzheimer's disease (AD), dementia with Lewy bodies (DLB), frontotemporal dementias (FTD) and vascular dementia (VaD).
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Gottfries, C. G. "Classifying Organic Mental Disorders and Dementia—A Review of Historical Perspectives." International Psychogeriatrics 3, S1 (March 1991): 9–17. http://dx.doi.org/10.1017/s1041610205001092.
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The concept of dementia should not be used synonymously with the concept of organic mental disorders. By definition, according to DSM-III and ICD-10, dementia is a syndrome which includes memory impairment. The severity of the disorder is disabling and the course is chronic. Differential diagnosis includes age-associated memory impairment (AAMI), delirium, and depressive disorders. The dementias may be subdivided into four groups: idiopathic (primary degenerative dementias), vascular, secondary, and others. The idiopathic dementias are those in which etiology is assumed to be found within the brain itself. The main subgroup is Alzheimer-type dementia. The vascular dementias are those in which the blood supply to the brain is insufficient. Multi-infarct dementia (MID) is the prototype. In secondary dementias, somatic disorders either within or external to the brain cause the dementia.
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Johnson, John. "Dementis to Dementia." British Journal of Psychiatry 151, no. 4 (October 1987): 562. http://dx.doi.org/10.1192/s0007125000217662.
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Corriveau, Roderick A., Walter J. Koroshetz, Jordan T. Gladman, Sophia Jeon, Debra Babcock, David A. Bennett, S. Thomas Carmichael, et al. "Alzheimer's Disease–Related Dementias Summit 2016: National research priorities." Neurology 89, no. 23 (November 8, 2017): 2381–91. http://dx.doi.org/10.1212/wnl.0000000000004717.
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Goal 1 of the National Plan to Address Alzheimer’s Disease is to prevent and effectively treat Alzheimer disease and Alzheimer disease–related dementias by 2025. To help inform the research agenda toward achieving this goal, the NIH hosts periodic summits that set and refine relevant research priorities for the subsequent 5 to 10 years. This proceedings article summarizes the 2016 Alzheimer's Disease–Related Dementias Summit, including discussion of scientific progress, challenges, and opportunities in major areas of dementia research, including mixed-etiology dementias, Lewy body dementia, frontotemporal degeneration, vascular contributions to cognitive impairment and dementia, dementia disparities, and dementia nomenclature.
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Potashkin, Judith A., Virginie Bottero, Jose A. Santiago, and James P. Quinn. "Bioinformatic Analysis Reveals Phosphodiesterase 4D-Interacting Protein as a Key Frontal Cortex Dementia Switch Gene." International Journal of Molecular Sciences 21, no. 11 (May 27, 2020): 3787. http://dx.doi.org/10.3390/ijms21113787.
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The mechanisms that initiate dementia are poorly understood and there are currently no treatments that can slow their progression. The identification of key genes and molecular pathways that may trigger dementia should help reveal potential therapeutic reagents. In this study, SWItch Miner software was used to identify phosphodiesterase 4D-interacting protein as a key factor that may lead to the development of Alzheimer’s disease, vascular dementia, and frontotemporal dementia. Inflammation, PI3K-AKT, and ubiquitin-mediated proteolysis were identified as the main pathways that are dysregulated in these dementias. All of these dementias are regulated by 12 shared transcription factors. Protein–chemical interaction network analysis of dementia switch genes revealed that valproic acid may be neuroprotective for these dementias. Collectively, we identified shared and unique dysregulated gene expression, pathways and regulatory factors among dementias. New key mechanisms that lead to the development of dementia were revealed and it is expected that these data will advance personalized medicine for patients.
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Chahyani, Wiwit Ida, and Murni Sri Hastuti. "Mixed Dementia: Tinjauan Diagnosis dan Tatalaksana." Muhammadiyah Journal of Geriatric 1, no. 2 (January 5, 2021): 46. http://dx.doi.org/10.24853/mujg.1.2.46-51.
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Latar Belakang: Prevalensi demensia saat ini semakin meningkat, mengenai usia diatas 65 tahun dan risikonya meningkat 2 kali setiap penambahan usia 5 tahun. Salah satu bentuk demensia adalah mixed dementia. Diagnosis mixed dementia sangat sulit dan memberikan tantangan tersendiri bagi para klinisi. Pada artikel ini, penulis ingin membahas mengenai tinjauan diagnosis dan tatalaksana mixed dementia. Hasil: Diagnosis mixed dementia dapat menggunakan beberapa kriteria yaitu International Classification of Diseases and Health Related Problems 10th Revision (ICD-10), the Alzheimer’s Disease Diagnostic and Treatment Centers (ADDTC), dan the National Institute of Neurological Disorders and Stroke and Association Internationale pour la Recherche et l’Enseignement en Neurosciences (NINDS-AIREN). Tatalaksana mixed dementia berupa terapi farmakologi untuk gejala gangguan kognitif dengan pemberian golongan inhibitor kolinesterase dan antagonis NMDA. Terapi farmakologi untuk gangguan psikis dan perilaku dengan antipsikotik atau antidepresan. Managemen faktor risiko hipertensi, konsumsi nutrisi yang sehat, dan olah raga teratur sebagai upaya preventif dan mencegah progresivitas mixed dementia. Kesimpulan: Diagnosis mixed dementia meliputi gejala demensia Alzheimer dan demensia pada penyakit serebrovaskuler. Tatalaksana mixed dementia meliputi terapi gangguan kognitif, psikis, dan perilaku, serta tatalaksana faktor risiko penyakit serebrovaskuler. Dibutuhkan penelitian lebih lanjut serta adanya konsensus diagnosis dan tatalaksana mixed dementia baik nasional maupun internasional agar tercapai tatalaksana secara komprehensif.
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Salardini, Arash. "An Overview of Primary Dementias as Clinicopathological Entities." Seminars in Neurology 39, no. 02 (March 29, 2019): 153–66. http://dx.doi.org/10.1055/s-0039-1683445.
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AbstractDementia is a state of cognitive dysfunction which leads to functional decline. It is a syndrome caused by several medical and neurological causes, but most cases of dementia are due to “primary dementias.” Primary dementias are neurological diseases whose manifestations are predominantly cognitive. Most primary dementias are caused by neurodegenerative proteinopathies where an accumulation of misfolded proteins leads to neuronal loss, neuroinflammation and glial reaction. Each proteinopathy is characterized by the type of protein implicated in its pathophysiology. Neurodegenerative dementias include the most prevalent cause of dementia—Alzheimer's disease—as well as Lewy body dementia, Parkinson's disease dementia, frontotemporal dementias, and prion diseases. Vascular dementia, especially small vessel disease, though not a neurodegenerative condition, is often grouped together with primary dementias. Each type of proteinopathy, characterized by the location and nature of misfolded protein accumulation, may correspond to a particular clinical phenotype. The correspondence between pathologies and clinical phenotypes is not exclusive, and there is a large degree of overlap. Although in the research setting the clinicopathological construct is on the wane, in the clinic it is the most practical way of approaching primary dementias. In this article, we introduce the clinicopathological construct, the understanding of which will form the basis of the other articles in this volume.
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Raz, Limor, Janice Knoefel, and Kiran Bhaskar. "The neuropathology and cerebrovascular mechanisms of dementia." Journal of Cerebral Blood Flow & Metabolism 36, no. 1 (July 15, 2015): 172–86. http://dx.doi.org/10.1038/jcbfm.2015.164.
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The prevalence of dementia is increasing in our aging population at an alarming rate. Because of the heterogeneity of clinical presentation and complexity of disease neuropathology, dementia classifications remain controversial. Recently, the National Plan to address Alzheimer’s Disease prioritized Alzheimer’s disease-related dementias to include: Alzheimer’s disease, dementia with Lewy bodies, frontotemporal dementia, vascular dementia, and mixed dementias. While each of these dementing conditions has their unique pathologic signature, one common etiology shared among all these conditions is cerebrovascular dysfunction at some point during the disease process. The goal of this comprehensive review is to summarize the current findings in the field and address the important contributions of cerebrovascular, physiologic, and cellular alterations to cognitive impairment in these human dementias. Specifically, evidence will be presented in support of small-vessel disease as an underlying neuropathologic hallmark of various dementias, while controversial findings will also be highlighted. Finally, the molecular mechanisms shared among all dementia types including hypoxia, oxidative stress, mitochondrial bioenergetics, neuroinflammation, neurodegeneration, and blood–brain barrier permeability responsible for disease etiology and progression will be discussed.
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Davis, Laura, and Tom Dening. "Diagnostic, management and nursing challenges of less common dementias: Parkinsonian dementias and Huntington's disease." British Journal of Neuroscience Nursing 17, no. 2 (April 2, 2021): 68–76. http://dx.doi.org/10.12968/bjnn.2021.17.2.68.
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Background: Although most cases of dementia are caused by Alzheimer's disease or vascular dementia, around 10-15% of cases are due to other disorders, including dementias with Parkinsonian features, Huntington's disease, frontotemporal dementia, human immunodeficiency virus (HIV), and alcohol. Aims: These less common dementias are important as they may have differing clinical features and require different approaches to diagnosis and management. This paper seeks to provide relevant information for nurses about symptoms, diagnosis and management of some of the less common dementias. Methods: This is one of two connected papers, and provides a clinical overview of Parkinsonian dementias and Huntington's disease. It provides a narrative, rather than systematic, review of the literature. Findings: Parkinsonian dementias comprise Parkinson's disease dementia, dementia with Lewy bodies and so-called Parkinson's-plus syndromes (multi-system atrophy, progressive supranuclear palsy, and corticobasal degeneration). Huntington's disease is an inherited neuropsychiatric condition. Each has a distinctive clinical picture, with combinations of cognitive, neuropsychiatric and neurological symptoms but approaches to treatment and care are essentially supportive. Conclusions: Nurses have an essential role in supporting people with dementia, as well their families and carers, throughout the course of dementia from diagnosis to end of life care. They are often best placed and have the necessary skills to create appropriate care plans and to provide care management.
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Zanni, Guido, and Jeannette Wick. "Differentiating Dementias in Long-Term Care Patients." Consultant Pharmacist 22, no. 1 (October 1, 2007): 14–28. http://dx.doi.org/10.4140/tcp.n.2007.14.
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Many long-term care residents are diagnosed with dementia, but dementia appears in many forms. Alzheimer's disease, the most common, is typified by a slow onset and relentless progression to complete incapacitation. Vascular dementia usually appears somewhat abruptly, is associated with vascular comorbidities, and has an unpredictable progression pattern. Lewy body dementia shares features of both Alzheimer's and Parkinson's disease; its hallmarks include fluctuating cognitive performance, visual hallucinations, and extrapyramidal motor symptoms. Frontotemporal dementias are associated less with memory disorders and more with behavioral and language aberrations. Mixed dementia covers those patients who do not have an apparent singular cause of dementia. Pseudodementia is a dementia resulting from underlying causes and is reversible, unlike the aforementioned dementias.
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Links, K. A., D. Merims, M. A. Binns, M. Freedman, and T. W. Chow. "Prevalence of Primitive Reflexes and Parkinsonian Signs in Dementia." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 37, no. 5 (September 2010): 601–7. http://dx.doi.org/10.1017/s0317167100010763.
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Objective:Primitive reflexes and parkinsonian signs are used by clinicians to differentiate among dementias. We reviewed our clinical sample to determine whether primitive reflexes were more prevalent in frontally-based dementias and whether parkinsonian signs were more common in dementia with Lewy bodies (DLB) than in other types of dementia.Design:We retrospectively reviewed charts from 204 patients with dementia who presented for consultation at Baycrest's Ross Memory Clinic between April, 2003, to December, 2007.Results:A greater proportion of subjects with DLB and dementia of the Alzheimer type with cardiovascular disease had primitive reflexes than subjects with frontotemporal dementia (FTD). Primitive reflexes were not positively predictive of FTD or vascular dementia (VaD). Dementia with Lewy bodies subjects were more likely to have parkinsonian signs than the other dementias, and bradykinesia and rigidity were positively predictive of FTD. The palmomental reflex was the most common primitive reflex in the sample, and cogwheeling was the most common parkinsonian sign. There was no significant difference between early- and late-stage groups in presence of primitive reflexes or parkinsonian signs.Conclusions:Primitive reflexes appear not to be clinically discriminative of frontally-based dementias such as FTD and VaD.
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Llanes-Álvarez, Carlos, Jesús M. Andrés-de llano, Ana I. Álvarez-Navares, Carlos Roncero, M. Teresa Pastor-Hidalgo, José R. Garmendia-Leiza, Irene Andrés-Alberola, and Manuel A. Franco-Martín. "Hospitalization and Socio-Health Care for Dementia in Spain." Journal of Clinical Medicine 9, no. 12 (November 28, 2020): 3875. http://dx.doi.org/10.3390/jcm9123875.
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Dementias are brain diseases that affect long-term cognitive and behavioral functions and cause a decrease in the ability to think and remember that is severe enough to disturb daily functioning. In Spain, the number of people suffering from dementia is rising due to population ageing. Reducing admissions, many of them avoidable, would be advantageous for patients and care-providers. Understanding the correlation of admission of people with dementia and its trends in hospitalization would help us to understand the factors leading to admission. We conducted a cross-sectional study of the hospital discharge database of Castilla y León from 2005 to 2015, selecting hospitalizations for dementia. Trends in hospitalizations by year and age quartiles were studied by joinpoint regression analysis. 2807 out of 2,717,192 total hospitalizations (0.10%) were due to dementias; the main groups were degenerative dementia (1907) followed by vascular dementia (607). Dementias are not a major cause of hospitalization, but the average stay and cost are high, and many of them seem avoidable. Decreasing trends were detected in hospitalization rates for all dementias except for the group of mild cognitive impairment, which grew. An increasing–decreasing joinpoint detected in 2007 for vascular dementia and the general downward hospitalization trends for most dementias suggest that socio-health measures established since 2007 in Spain might play a key role in reducing hospitalizations.
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Malikal Balqis, Ummi, and Junaiti Sahar. "Pengalaman Lansia dengan Demensia Ringan-Sedang Dalam Melakukan Komunikasi dengan Pelaku Rawat: Systematic Review." Jurnal Endurance 4, no. 2 (July 15, 2019): 388. http://dx.doi.org/10.22216/jen.v4i2.4046.
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<p><em>Dementia is a progressive decline in cognitive abilities that characterized by memory loss that affects everyday abilities. One of the most common problems in elderly with dementia is communication problem. The purpose of this systematic review is to explore the experience of elderly with mild-moderate dementia in communicating with caregivers. This article uses the systematic review method to all selected articles. Through this systematic review approach, six selected themes in phenomenology journals explain that elderly with mild-moderate dementia can describe the symptoms of dementia experienced, feelings of loss and stress caused of dementia, negative stigma towards elderly dementia, loss of control and desire to make their own decisions, and problems in interpersonal relationships. The ability of elderly with mild-moderate dementia in communicating their experiences when interacting with caregivers can be a consideration for caregivers in making decisions related to the condition of their experience in elderly with dementia</em></p><p> </p><p><em>Demensia merupakan penurunan secara progresif pada kemampuan kognitif yang ditandai dengan </em><em>kehilangan memori yang mempengaruhi kemampuan sehari-hari. Salah satu masalah yang cukup dominan dirasa pada lansia demensia yaitu masalah di dalam komunikasi. Tujuan dari penulisan ini adalah untuk melihat pengalaman lansia dengan demensia ringan-sedang dalam melakukan komunikasi dengan pelaku rawat. </em><em>Artikel ini menggunakan metode penulisan systematic review </em><em>terhadap artikel terpilih. Melalui pendekatan systematic review ini, enam</em><em> jurnal fenomenologi terpilih menyebutkan bahwa </em><em>tema-tema yang muncul saat lansia dengan demensia ringan-sedang melakukan komunikasi dengan pelaku rawat</em><em>, diantaranya lansia mampu untuk menceritakan gejala demensia yang dialami, perasaan kehilangan dan tertekan, stigma negatif orang lain, kehilangan kendali dan keinginan untuk mengambil keputusan sendiri, serta masalah di dalam hubungan interpersonal</em><em>. Kemampuan lansia dengan demensia ringan-sedang dalam mengungkapkan pengalamannya ketika berinteraksi dengan pelaku rawat dapat menjadi pertimbangan bagi pelaku rawat dalam menentukan keputusan pemberian pelayanan berkaitan dengan kondisi demensia yang dialaminya</em></p>
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Mahalingam, Sowmya, and Ming-Kai Chen. "Neuroimaging in Dementias." Seminars in Neurology 39, no. 02 (March 29, 2019): 188–99. http://dx.doi.org/10.1055/s-0039-1678580.
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AbstractDementia is a global health issue, the burden of which will worsen with an increasingly aging population. Alzheimer's disease (AD) is the most common dementia, with 50 to 60% of all dementias attributable to AD alone, while the rest are mostly due to frontotemporal lobar dementia, dementia with Lewy bodies, Parkinson's disease dementia, and vascular dementia. Diagnosis of dementias is made clinically with the aid of other testing modalities including neuroimaging. While the role of imaging has traditionally been to exclude reversible causes of dementia, positron emission tomography (PET) with 18-fluorine fluorodeoxyglucose and magnetic resonance imaging now are increasingly used more for definitive diagnosis of dementia in the prodromal stages and to aid with formulating the differential diagnoses. Introduction of molecular imaging modalities such as amyloid PET and tau PET have improved diagnostic certainty in the clinical trial setting and promise to find their way into the clinic in the near future. In this review, we will focus on the multimodality imaging of dementias especially AD and its differential diagnoses.
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Bello, Valeska Maria Eboli, and Rodrigo Rizek Schultz. "Prevalence of treatable and reversible dementias: A study in a dementia outpatient clinic." Dementia & Neuropsychologia 5, no. 1 (March 2011): 44–47. http://dx.doi.org/10.1590/s1980-57642011dn05010008.
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Abstract Dementia is a syndrome characterized by the development of multiple cognitive deficits and behavioral changes that leads to impairment of functional activities. There are primary degenerative, progressive and irreversible dementias, and other dementias resulting from a progressive but potentially reversible dementia of secondary origin. Objective: To assess the prevalence of cases with a diagnosis of potentially reversible dementia at a Behavioral Neurology Outpatient Unit. Methods: A retrospective study based on a review of 340 medical records of patients seen from 1999 to 2009 was conducted. All patients received a thorough diagnostic assessment to verify the etiological hypothesis proposed. Results: Of the 340 patients seen in the study period, 172 (50.5%) were females and 168 (49.5%) males, 90 patients (26.4%) were under 60 years of age, and 250 (73.6%) were over 60 years of age. Alzheimer's disease, with 89 cases (26%), followed by vascular dementia with 39 cases (11.47%), were the leading etiological diagnoses. A total of 193 patients had dementia and 37 of these (19.17%) were found to have potentially reversible dementias, distributed as follows: head injury: 15 patients; alcohol-related dementias: 11 patients; meningoencephalitis: 2 patients; hypothyroidism: 2 patients; neurosyphilis: 2 patients; normal pressure hydrocephalus: 2 patients; AIDS: 1 patient; Korsakoff's syndrome: 1 patient, and Post-anoxic dementia: 1 patient. Conclusions: A significant number of patients were found to have potentially reversible dementias (19.17%). These data show an urgent need for more extensive diagnostic investigation, and indicate the possibility of reversing some dementias, especially cases detected early.
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Mikhaylova, N. M. "Old Age Dementia: Clinical Patterns of Progression. Part 1." Psikhiatriya 18, no. 3 (September 20, 2020): 108–20. http://dx.doi.org/10.30629/2618-6667-2020-18-3-108-120.
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Background: the clinical experience testifies to the fact, that the increase of dementia severity in late age occurs quickly in some cases and in others it proceeds slowly, which is reflected in the total duration of the disease and survival. One of the aspects of dementias research is the study of significant differences in dementia progression rates.The objective of the review was to generalize the obtained data on progression rates of late age dementias of various genesis, first of all due to Alzheimer’s disease and its associated disorders.Material and methods: papers in MedLine/PubMed bases from1990 to 2020 were selected and analyzed according to the key words: “old age”, “dementia”, “Alzheimer’s disease”, “vascular dementia”, “progression”, “progression rate”, “disease trajectories”, as well as relevant papers in the references of the analyzed works.Conclusion: the history of research of old age dementias natural course was presented in the review of scientific publications. According to the results of development of progression rates detection methods, singling out of dementias with rapid and slow increase in the severity of cognitive decline was substantiated. Works devoted to the study of frequency and nosological belonging of dementias with different progression rates were considered. In the most recent studies prognostic models with detection of various trajectories of the course of the disease were developed. The concept of various dementias progression rates admittedly has practical meaning for provision of diagnostic and treatment assistance and planning of medical and social support measures for patients with dementia and their families. Differentiation of dementia progression clinical patterns during formation of comparable groups of patients seems appropriate for investigation of new therapy methods, as well as in clinical-biological studies of pathogenesis.
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Tisher, Annya, and Arash Salardini. "A Comprehensive Update on Treatment of Dementia." Seminars in Neurology 39, no. 02 (March 29, 2019): 167–78. http://dx.doi.org/10.1055/s-0039-1683408.
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AbstractTreatment of dementias represents an important but relatively neglected part of neurological care of the elderly population. Individual therapeutic interventions may make only small changes to the quality of life of individuals afflicted with dementia, but when used in combination these interventions synergize and can make a significant difference. Additionally, given the societal scale of the problem of dementia care, the overall impact, in economic and sociological terms, of such therapies is of consequence. Presently there are no disease-modifying treatments for any of the neurodegenerative dementias. Instead, the clinician has several therapeutic tools to mitigate cognitive and behavioral consequences of dementias. There are also strategies to minimize harm to patients with dementia. In this article, we aim to review these tools and place them in the greater context of dementia care.
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Copeland, J. R. M., Cherie McCracken, M. E. Dewey, K. C. M. Wilson, Mark Doran, Chris Gilmore, Anne Scott, and Bernie Larkin. "Undifferentiated dementia, Alzheimer's disease and vascular dementia: Age- and gender-related incidence in Liverpool." British Journal of Psychiatry 175, no. 5 (November 1999): 433–38. http://dx.doi.org/10.1192/bjp.175.5.433.
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BackgroundDoes incidence of dementia follow the age pattern of prevalence? Is gender a risk factor? Do patterns of incidence differ between dementias?AimsTo assess age-specific incidence rates of undifferentiated dementias, Alzheimer's disease and vascular dementia.Method5222 individuals aged $65 years, were interviewed using the Geriatric Mental State/History and Aetiology Schedule. The AGECAT package was used to identify cases at three interviewing waves at two-year intervals. Diagnoses were made using ICD −10 Research Criteria and validated against neurological and psychological examination, with imaging and neuropathology on unselected subsamples.ResultsIncidence rates of the dementias increase with age. Age patterns are similar between Alzheimer's disease and vascular dementia. Gender appears influential in Alzheimer's disease. In England and Wales, 39 437 new cases of Alzheimer's disease (4.9/1000 person-years at risk); 20 513 of vascular dementia (2.6/1000 person-years) and 155 169 of undifferentiated dementia (19/1000 person-years) can be expected each year.ConclusionsIncidence rates for Alzheimer's disease and vascular dementia appear to behave differently with an increased risk of Alzheimer's disease for women compared to vascular dementia.
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Purnakarya, Idral. "Defisiensi Riboflavin dan Demensia pada Usia Lanjut." Kesmas: National Public Health Journal 6, no. 3 (December 1, 2011): 99. http://dx.doi.org/10.21109/kesmas.v6i3.99.
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Demensia Alzheimer menempati urutan kesembilan penyebab kematian di Amerika Serikat. Demensia adalah kondisi yang sering dialami yang berhubungan dengan berbagai faktor dan gaya hidup terutama diet. Penelitian ini bertujuan untuk mengetahui hubungan defisiensi asupan riboflavin (vitamin B12) dengan demensia pada usia lanjut (usila). Penelitian ini menggunakan desain studi cross sectional dan dilaksanakanpada bulan September 2007 sampai dengan Januari 2008. Sampel penelitian adalah 141 lansia berumur lebih dari sama dengan 60 tahun yang diambil secara purposive sampling. Demensia diukur menggunakan kuesioner MMSE (² 24, skor maksimum 30) dan asupan riboflavin diukur menggunakan form Semi Quantitative – FFQ. Penelitian ini memperlihatkanbahwa 47,5% usila mengalami demensia. Hasil uji statistik menunjukkan bahwa terdapat hubungan yang signifikan antara umur, tingkat pendidikan, dan asupan riboflavin dengan kejadian demensia pada usila (nilai p < 0,05).Kata kunci: Demensia, defisiensi riboflavin, usia lanjutAbstractDementia Alzheimer’s was ranked the ninth leading cause of death in The United States. Dementia can not be avoided as related to several factors and lifestyle especially the diet. The objective of this research is to know relation the deficiency of riboflavine (vitamin B12) intake and incidence of dementiaat elderly. A cross-sectional study was conducted betweenSeptember 2007 and January 2008. The sample obtained was 141 elderly which it was conducted to purposive sampling. Dementia was measured by using questionnaire MMSE (² 24, maximum score was 30), and riboflavine intake was measure by Semi Quantitative – FFQ form. This study shows that dementia in elderly was 47,5%. Statistical test showed that Statistical test showed that incidence of dementia had significantly associated with ages, level of education, and riboflavine intake (p value < 0,05).Key words: Dementia, deficiency of riboflavine, elderl
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Sánchez Iglesias, Ana, José Antonio Del Barrio, Josefa González-Santos, Florencio Vicente Castro, Jerónimo González, David Padilla Góngora, Alfredo Jiménez, et al. "MINDFULNESS Y REHABILITACIÓN NEUROCOGNITIVA." International Journal of Developmental and Educational Psychology. Revista INFAD de Psicología. 1, no. 1 (October 2, 2017): 21. http://dx.doi.org/10.17060/ijodaep.2017.n1.v1.895.
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Abstract.MINDFULNESS AND NEUROCOGNITIVE REHABILITATION.Nowadays approximately fifty million persons are suffering from dementia throughout the world according to the latest statistics of the European Commission (2016). Moreover, every year new 7.7 million instances of this disease are detected. At this moment, Alzheimer’s disease would be the most common mental disorder in terms of world population health, in other words, this disease can signify 70% of all dementia. Even now pharmacological treatments are ineffective. Consequently, utilization of non pharmacological therapies is opening a wide range of possibilities aimed to increase prevention and, at the same time, improvement in living standards of careers and relatives of patients with dementia who are usually overburdened. This presentation contains a review about researches on mindfulness (MF) and its implementation like potentially strategies aimed to treat this disorder.Keywords: Dementias, Mindfulness, Neuroimagen, meta-analysis.Resumen.Los últimos datos aportados por la Comisión Europea señalan que la demencia afecta actualmente a casi cincuenta millones de personas en todo el mundo y que cada año se detectan 7.7 millones de nuevos casos. A día de hoy, el Alzheimer es la demencia más padecida por la población mundial pudiendo constituir en términos relativos el 70% de las demencias. En la actualidad no existen tratamientos farmacológicos que den una respuesta definitiva a este tipo de patologías. Las utilizaciones de terapias no farmacológicas abren un amplio abanico de posibilidades desde el ámbito de la prevención, y de la mejora de la calidad de vida en cuidadores y familiares de enfermos con demencia, básicamente con sintomatología de “sobrecarga”. En este articulo hacemos una revisión sobre investigaciones relacionadas con la “atención plena” ( MF) y de su implementación como estrategias potenciales en el abordaje de este tipo de patologías. Los últimos trabajos aportados con técnicas morfométricas por neuroimagen constituyen un importante avance a la hora de intentar aportar evidencia científica en este campo.Palabras clave: Demencias, Mindfulness, Neuroimagen, Meta-análisis, Rehabilitación.
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Rockwood, Kenneth. "Mixed Dementia: Alzheimer's and Cerebrovascular Disease." International Psychogeriatrics 15, S1 (July 2003): 39–46. http://dx.doi.org/10.1017/s1041610203008949.
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“Mixed dementia” is traditionally defined as Alzheimer's disease with cerebrovascular disease (CVD). Because the risks of both neurodegenerative dementias and cerebrovascular disease increase with age, the mixed dementias are likely the most common. In practice, patients with mixed dementia are diagnosed by one of two routes: Either they have evidence of a neurodegenerative dementia and CVD at the outset, or, they have a classical neurodegenerative presentation but are found to have ischemic lesions by neuroimaging. These facts have implications for the development of evidence-based diagnostic criteria.
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Klimova, Blanka, Petra Maresova, and Kamil Kuca. "Combat Military Personnel and Selective Risk Factors for the Development of Dementias - A Review." Current Psychiatry Research and Reviews 15, no. 1 (May 2, 2019): 44–48. http://dx.doi.org/10.2174/1573400515666190114155451.
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: Due to the growth of life expectancies and the increasing number of elderly population all over the world, there is a risk of growth of aging diseases such as dementia. Recent research studies also indicate that there will be a growing number of military veterans who will be affected by dementia, already at the age of 55+ years. In the case of combat military personnel, the most common dementias are Alzheimer’s disease and vascular dementia. These two dementias are very similar because their main symptoms are the same. The purpose of this review is to explore two main risk factors influencing the development of the dementias. These include posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI). Furthermore, the authors of this study focus on the exploration of the treatment of PTSD and TBI in order to delay the development of dementias among combat military personnel. : For the purpose of this study, a method of literature review of available sources exploring these two main risk factors of dementia among combat military personnel was used. Based on the evaluation of these literature sources, possibilities of pharmacological and non-pharmacological approaches to the treatment and care of these people were described.
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Larson, Eric B. "Prospects for delaying the rising tide of worldwide, late-life dementias." International Psychogeriatrics 22, no. 8 (July 1, 2010): 1196–202. http://dx.doi.org/10.1017/s1041610210001080.
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ABSTRACTWorldwide, lifespan is lengthening. Concomitantly, late-life dementias are increasingly common, challenging both personal and public health internationally. After age 65, rates of dementia tend to double every five years in developed countries and every seven in developing ones. The late-life dementias, particularly Alzheimer's disease, have profound effects on aging individuals and their caregivers. Multidisciplinary research has explored the potential for various approaches to prevent or delay the onset of late-life dementias. Outlining that research, including our team's Adult Changes in Thought and Kame studies, this review concludes that delaying the onset of these dementias appears feasible, although absolute prevention may not be. Today, the most promising methods appear to include controlling vascular risk factors like hypertension and engaging in physical exercise – and possibly mental exercise. If people can delay the onset of dementias, they can lead more fulfilling lives for longer, spending less time suffering from dementia and letting their families spend less time coping with the disease. It is possible that trends toward more knowledge-based societies, where cognitive health is so vital, may increasingly exert evolutionary pressure favoring larger and healthier brains – and a “compression of cognitive morbidity” – well into old age. Public health's great triumph, increased lifespan, should give more of the world's people the reward of many years of dementia-free life. Rather than the personal difficulties and public health burdens of many years of functional impairment, dependency, and suffering with dementia, some interventions may delay the onset of Alzheimer's disease and other dementias.
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Camicioli, Richard, and Nancy Fisher. "Progress in Clinical Neurosciences: Parkinson's Disease with Dementia and Dementia with Lewy Bodies." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 31, no. 1 (February 2004): 7–21. http://dx.doi.org/10.1017/s0317167100002791.
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Dementia occurs in up to 30% of people with Parkinson's disease and is a major cause of disability. Pathologically, Parkinson's dementia, where dementia follows the onset of parkinsonism by at least one year, overlaps with dementia with Lewy bodies. We review the functional impact, definitions, neuropsychology, epidemiology and pathophysiology of Parkinson's dementia, dementia with Lewy bodies and their overlap. Associated psychiatric and imaging findings are also considered. Lastly, current and emerging approaches to assessment and treatment in patients with these Lewy body associated dementias are presented.
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Surahmawati, Surahmawati, Yuni Kartika, and Sitti Raodhah. "Hubungan Kebiasaan Membaca Alqur’an dan Aktivitas Fisik dengan Demensia Pada Lanjut Usia." JURNAL KESEHATAN POLTEKKES KEMENKES RI PANGKALPINANG 8, no. 2 (December 31, 2020): 87. http://dx.doi.org/10.32922/jkp.v8i2.290.
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Abstrak
Latar belakang: Demensia merupakan salah satu masalah kesehatan utama dikalangan lansia. WHO mencatat pada tahun 2016 diperkirakan angka kejadian demensia sebanyak 47,5 juta orang dan diperkirakan akan meningkat menjadi 75,6 juta orang pada tahun 2030 dan 135,5 juta orang di tahun 2050.
Tujuan : Untuk mengetahui hubungan antara kebiasaan membaca Al-Qur’an dan aktivitas fisik dengan demensia pada lanjut usia yang berkunjung di posyandu lansia desa Baringeng Kabupaten Soppeng, Provinsi Sulawesi Selatan tahun 2020
Metode: Penelitian ini merupakan observasional analitik menggunakan desain cross sectional. Jumlah responden adalah 53 lansia diambil dengan cara total sampling, pengumpulan data menggunakan kuesioner, analisis data menggunakan uji statistik Kolmogorov-Smirnov.
Hasil : Hasil uji statistik Kolmogorov-Smirnov didapatkan ada hubungan antara kebiasaan membaca Al-Qur’an dengan demensia, dengan p value = 0.000 dan ada hubungan antara aktivitas fisik dengan demensia, dengan p value = 0.000
Kesimpulan: Terdapat hubungan antara kebiasaan membaca Al-Qur’an dan aktivitas fisik dengan demensia pada lanjut usia yang berkunjung di posyandu lansia desa Baringeng tahun 2020.
Kata kunci: Demensia, Kebiasaan membaca Al-Qur’an, Aktivitas fisik.
Abstract
Background: Dementia is one of the main health problems among the elderly. WHO noted that in 2016, it was estimated that the incidence of dementia was 47.5 million people and it is estimated that it will increase to 75.6 million people in 2030 and 135.5 million people in 2050.
Objective: To find out the relationship between the habit of reading the Qur'an and physical activity with dementia in the elderly who visit the posyandu for the elderly in Baringeng Village, Soppeng Regency, South Sulawesi Province in 2020.
Methode: This research is an observational analytic using cross sectional design. The number of respondents was 53 elderly taken by total sampling, data collection using a questionnaire, data analysis using the Kolmogorov-Smirnov statistical test.
Results : The results of the analysis with the Kolmogorov-Smirnov statistical test found that there was a relationship between the habit of reading the Qur'an and dementia, with p value = 0.000 and there was a relationship between physical activity and dementia, with p value = 0.000.
Conclusion: there is a relationship between the habit of reading the Qur'an and physical activity with dementia in the elderly who visit the posyandu for elderly in Baringeng village in 2020.
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Salardini, Arash. "Interpretation of Biomarker Data in Diagnosis of Primary Dementias." Seminars in Neurology 39, no. 02 (March 29, 2019): 200–212. http://dx.doi.org/10.1055/s-0039-1683380.
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AbstractIn the last few years, an improved understanding of dementia biomarkers has significantly increased the diagnostic accuracy for dementias. The National Institutes of Health Biomarkers Definitions Working Group defines a biomarker as “a characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention.” In the field of dementia, a biomarker is a biological measure pointing to a specific dementing pathology. Dementia biomarkers may also serve as surrogates for disease progression and as endpoints in clinical trials. Dementia biomarkers are best characterized for Alzheimer's disease, which is the most common form of primary dementia. The current “biological” conception of Alzheimer's disease is based on consideration of three biomarkers: amyloid, tau, and “neurodegeneration.” The status of these biomarkers may be determined by cerebrospinal fluid clinical chemistry or imaging. Biomarkers for other primary dementias are less reliable and rely chiefly on structural and functional imaging. When appropriate, genetic testing may help with diagnostic certainty in hereditary forms of dementia.
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Aevarsson, Ólafur, and Ingmar Skoog. "Dementia Disorders in a Birth Cohort Followed From Age 85 to 88: The Influence of Mortality, Refusal Rate, and Diagnostic Change on Prevalence." International Psychogeriatrics 9, no. 1 (March 1997): 11–23. http://dx.doi.org/10.1017/s104161029700416x.
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The prevalence of dementia increased in women (from 31% to 46%) but not in men (from 27% to 25%) in a representative birth cohort followed from age 85 to 88. The increase was mostly attributed to a higher rate of new cases among women than among men. The proportion of moderate to severe dementia increased, and mild dementia decreased, mainly because of progression of mild dementias to severer forms and because most new cases were of moderate to severe degree. The proportion of vascular dementia was 47% at age 85 and 54% at 88 despite a higher mortality in vascular than in other dementias. Diagnosis changed to vascular dementia in 9 out of 31 cases of Alzheimer's disease because of new cerebrovascular events. This study illustrates that prevalence is influenced by several factors, such as number of new cases, refusal rate, diagnostic change, and mortality. These factors act in different directions and may differ between populations.
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LoGiudice, D., and A. Hassett. "Uncommon dementia and the carer's perspective." International Psychogeriatrics 17, s1 (September 2005): S223—S231. http://dx.doi.org/10.1017/s1041610205002048.
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There is much caregiving literature describing factors that affect carer burden, and interventions that may be useful for carers of those with common dementias such as Alzheimer's disease (AD). By contrast, relatively little information and few data are available on potentially diverse issues facing carers of those with uncommon dementias, such as frontotemporal dementia (FTD), Huntington's disease (HD) and human immunodeficiency virus (HIV) dementia. This paper highlights particular characteristics of caregiving for those with uncommon dementias, and the unique needs that may arise for this group of carers who often “fall between the net” of services and supports available. Further research into this area is required.
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Chertkow, H., H. Bergman, H. M. Schipper, A. M. Clarfield, S. Gauthier, S. Fontaine, and R. Bouchard. "Assessment of Suspected Dementia." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 28, S1 (May 2001): S28—S41. http://dx.doi.org/10.1017/s0317167100001189.
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At the Second Canadian Consensus Conference on Dementia (CCCD) (February, 1998), a group of neurologists, geriatricians, and psychiatrists met to consider guidelines for evaluation of dementia in Canada. This review paper formed a background paper for their discussion of dementia diagnosis. These experts from across the country concluded that diagnosis of suspected dementia cases continued to rest on skilled clinical assessment. Mental status exam, preferably in some quantifiable form, has become an essential part of the assessment. Selected laboratory tests are advisable in all cases (CBC, TSH, electrolytes, calcium, and glucose), but the CCCD continued to advise that CT scanning was mandatory only in selected cases where clinical findings pointed to another possibility besides Alzheimer’s disease. The growing list of other diagnostic measures with potential usefulness in diagnosis of Alzheimer’s disease or dementia in general was reviewed, but the evidence was judged as insufficient to support routine use of these tests by physicians. As new treatments for Alzheimer’s disease become available, neurologists face new diagnostic challenges - differentiating Mild Cognitive Impairment, Frontotemporal dementias and Mixed dementias, and Lewy Body Dementia. Guidelines to aid in differential diagnosis are presented.
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Tang, Kim S. "Protective Effects of Polydatin Against Dementia-Related Disorders." Current Neuropharmacology 19, no. 2 (December 31, 2020): 127–35. http://dx.doi.org/10.2174/1570159x18666200611144825.
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: Dementia is a collection of symptoms affecting a person’s cognition. Dementia is debilitating, and therefore, finding an effective treatment is of utmost importance. Resveratrol, which exhibits neuroprotective effects, has low bioavailability. However, its glucoside polydatin is more bioavailable. Here, the evidence that supports the protective role of polydatin against dementia- related diseases such as Alzheimer’s disease, vascular dementia, alcohol-related dementia, and Lewy body dementias is presented. The beneficial effects of polydatin from a mechanistic perspective are specifically emphasized in this review. Future directions in this area of research are also discussed.
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Hogan, David B., Daniel E. Thierer, Erika M. Ebly, and Irma M. Parhad. "Progression and Outcome of Patients in a Canadian Dementia Clinic." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 21, no. 4 (November 1994): 331–38. http://dx.doi.org/10.1017/s0317167100040919.
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Abstract:Five hundred and fifty-three patients were referred to a Canadian dementia clinic for standardized evaluation. The majority (83.5%) had a dementia with Alzheimer’s disease (AD) accounting for 89% of dementias. Patients with probable AD who were followed for five years had variable rates of progression, increased mortality (37.1%, 2.5 times the expected rate) and a high rate of institutionalization (79%). Simple demographic (age) and social factors (marital status) were strong predictors for institutionalization. It was extremely difficult at presentation to predict the rate of progression. The prevalence of AD in autopsied cases was 62.5%. Clinic patients were younger, had milder dementias, and were more likely to have AD than patients identified in the course of a contemporaneous population-based dementia prevalence study.
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Mayeda, Elizabeth Rose. "Invited Commentary: Examining Sex/Gender Differences in Risk of Alzheimer Disease and Related Dementias—Challenges and Future Directions." American Journal of Epidemiology 188, no. 7 (March 2, 2019): 1224–27. http://dx.doi.org/10.1093/aje/kwz047.
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Abstract The majority of people living with Alzheimer disease (AD) and related dementias are women. Longer life expectancy is one factor thought to contribute to this observation, but possible sex-specific biological mechanisms have received considerable attention from the research community. In the current issue of the Journal, Buckley et al. (Am J Epidemiol. 2019;188(7):1213–1223) use death certificate information on all deaths occurring among adults aged ≥60 years in Australia between 2006 and 2014 to evaluate sex/gender differences in rates of death with dementia (all types), AD dementia, and vascular dementia listed on the death certificate. The paper by Buckley et al. highlights several important methodological challenges for research examining sex/gender differences in risk of AD and related dementias, including challenges in measurement, survival bias and competing risks, and selection bias arising from sample selection. The current evidence on possible sex-specific biological risk factors for AD is intriguing, but there are numerous alternative explanations for differences in AD dementia and AD biomarkers between women and men. Triangulation of evidence from study designs with different strengths and weaknesses and transdisciplinary collaboration will be vital to generating conclusive evidence about sex/gender differences in risk of AD and related dementias.
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Abdillah, Awaludin Jahid, and Ayu Pradana Octaviani. "PENGARUH SENAM OTAK TERHADAP PENURUNAN TINGKAT DEMENSIA." Jurnal Kesehatan 9, no. 2 (March 14, 2020): 1190–97. http://dx.doi.org/10.38165/jk.v9i2.86.
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Demensia berhubungan dengan fungsi otak, karena kemampuan lansia untuk berpikir akan dipengaruhi oleh keadaan otak. Peningkatan daya kognitif dapat dilakukan salah satunya dengan senam otak (brain gym). Penelitian ini bertujuan untuk mengetahui pengaruh senam otak terhadap penurunan tingkat demensia pada lansia di Wilayah Kerja Puskesmas Kesambi Kota Cirebon Tahun 2017.Jenis penelitian ini menggunakan desain penelitian quasi eksperimental design yaitu dengan pendekatan one group pretest posttest design menggunakan satu kelompok subjek. Pengambilan sampel menggunakan total sampling dengan jumlah sampel 25 responden. Metode pengumpulan data dengan wawancara dan demensia diukur dengan MMSE (Mini Mental State Exam) Analisis data yang digunakan adalah uji Paired Samples Test.Hasil penelitian menunjukkan sebelum dilakukan intervensi lansia dengan demensia ringan 9 orang (36%), setelah dilakukan intervensi lansia dengan demensia ringan 14 orang (56%). Dari hasil uji statistik didapatkan nilai p value adalah 0,011 dengan demikian p value < 0,05 yang berarti terdapat pengaruh senam otak terhadap penurunan tingkat demensia pada lansia di Wilayah Kerja Puskesmas Kesambi Kota Cirebon Tahun 2017.Kata Kunci : Senam Otak, Demensia ABSTRACTDementia is associated with brain function. It is because the ability of the elderly to think will be influenced by the state of the brain. To inprove cognitive power can be done by doing such as with brain gym. This study is aimed to determine the effect of brain gymnastics to the decrease rate of dementia on the elderly in Puseksmas Kesambi Cirebon in the year of 2017.This research uses quasi experimental research which is designed by approaching one group pretest and another group using one group of subjects. To get the sample the research used total sampling with a sample of 25 respondents. Dementia is measured by the MMSE (Mini Mental State Exam). The analysis of the data which was used is paired samples test.The results showed, before conducting the threatment, there were 9 people of the elderly with the mild dementia category or its amount (36%). Moreover, after conducting the treatment, there were 14 people of the elderly with the mild dementia category or it is amount (56%). From the test results obtained statistical p value is 0,011 thus p value < 0,15. Which means that there is a brain gym influence on the elderly in Puseksmas Kesambi Cirebon in the year of 2017.Keywords : Brain Gym, Dementia
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Arruda, Elizabeth H., and Olimpia Paun. "Dementia Caregiver Grief and Bereavement: An Integrative Review." Western Journal of Nursing Research 39, no. 6 (July 13, 2016): 825–51. http://dx.doi.org/10.1177/0193945916658881.
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Alzheimer’s disease and related dementias make up the fifth leading cause of death for individuals of 65 years of age and older in the United States. Seventy percent of these individuals will die in long-term care settings. The aim of this integrative review was to examine and synthesize the evidence on grief and bereavement in Alzheimer’s disease and related dementias caregivers. This review identified five critical gaps in the existing evidence: (a) a lack of ethnic and gender diversity among caregivers studied, (b) limited use of valid instruments to study dementia caregiver grief and bereavement, (c) no substantive research examining dementia caregiver grief and bereavement for caregivers whose family members die in long-term care, (d) a lack of evidence examining the effect of hospice services on dementia caregiver grief and bereavement, and (e) a lack of grief and bereavement interventions for dementia caregivers whose family members die in long-term care.
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Bansal, Nitin, and Milind Parle. "Dementia: An Overview." Journal of Pharmaceutical Technology, Research and Management 2, no. 1 (May 5, 2014): 29–45. http://dx.doi.org/10.15415/jptrm.2014.21003.
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Tan, Lynnette Pei Lin, Nathan Herrmann, Brian J. Mainland, and Kenneth Shulman. "Can clock drawing differentiate Alzheimer's disease from other dementias?" International Psychogeriatrics 27, no. 10 (July 3, 2015): 1649–60. http://dx.doi.org/10.1017/s1041610215000939.
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ABSTRACTBackground:Studies have shown the clock-drawing test (CDT) to be a useful screening test that differentiates between normal, elderly populations, and those diagnosed with dementia. However, the results of studies which have looked at the utility of the CDT to help differentiate Alzheimer's disease (AD) from other dementias have been conflicting. The purpose of this study was to explore the utility of the CDT in discriminating between patients with AD and other types of dementia.Methods:A review was conducted using MEDLINE, PsycINFO, and Embase. Search terms included clock drawing or CLOX and dementia or Parkinson's Disease or AD or dementia with Lewy bodies (DLB) or vascular dementia (VaD).Results:Twenty studies were included. In most of the studies, no significant differences were found in quantitative CDT scores between AD and VaD, DLB, and Parkinson's disease dementia (PDD) patients. However, frontotemporal dementia (FTD) patients consistently scored higher on the CDT than AD patients. Qualitative analyses of errors differentiated AD from other types of dementia.Conclusions:Overall, the CDT score may be useful in distinguishing between AD and FTD patients, but shows limited value in differentiating between AD and VaD, DLB, and PDD. Qualitative analysis of the type of CDT errors may be a useful adjunct in the differential diagnosis of the types of dementias.
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Bouchard, Rémi W. "Diagnostic Criteria of Dementia." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 34, S1 (March 2007): S11—SS18. http://dx.doi.org/10.1017/s0317167100005497.
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In the past two decades there has been a tremendous effort among clinicians and searchers to improve the diagnostic criteria of the dementias on the basis of the differential neurological and neuropsychological profiles. This was an obligatory requirement for clinical trials and the development of treatments. Over the years it became rapidly evident that the cohorts of patients in studies had some degree of heterogeneity, making it difficult to interpret the results of some studies, particularly in the vascular dementias and the mild cognitive impairment (MCI) group. For example, many sub-types of the vascular group were included in clinical trials, such as the cortical strokes, the lacunar states and the diffuse white matter disease cases, and some of the patients might have had also mixed pathology. In addition, the standard DSM IV criteria for dementia no longer represent our present knowledge of the clinical profile of some of the dementias such as vascular dementia (VaD) and fronto-temporal dementia where the memory impairment is not necessarily the first requirement. To improve the validity of clinical trials and eventually help developing more appropriate treatments, we revised the present diagnostic criteria and made recommendations for some changes in the context of the 2nd Canadian Conference on the Development of Antidementia Therapies, held in 2004 and reviewed in the light of the recent literature as of early 2006. It is expected that in the near future, these dementia criteria for clinical trials will have to be revised again in order to include specific subtypes of the dementias as well as biomarkers, structural and functional imaging.
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STERN, YAAKOV, MING-XIN TANG, DIANE M. JACOBS, MARY SANO, KAREN MARDER, KAREN BELL, GEORGE DOONEIEF, PETER SCHOFIELD, and LUCIEN CÔTÉ. "Prospective comparative study of the evolution of probable Alzheimer's disease and Parkinson's disease dementia." Journal of the International Neuropsychological Society 4, no. 3 (May 1998): 279–84. http://dx.doi.org/10.1017/s1355617798002793.
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No previous comparison of test performance in probable Alzheimer's disease (pAD) and Parkinson's disease (PD) dementia has provided information about potential differences in the dementing process. This study compared the evolution of cognitive changes associated with these dementias. Generalized estimating equations (GEE) applied to regression analyses with repeated measures were used to evaluate cognitive changes over 1 to 3 years prior to the point when dementia was diagnosed in 40 matched pairs of patients with incident pAD and PD dementia. Both groups' performance declined on the Short Blessed, Selective Reminding Test (SRT; total recall, long-term retrieval, and delayed recall), Boston Naming Test, Category Fluency, and Similarities. The decline on naming and SRT delayed recall was more rapid in the PD dementia group, suggesting that these performance deficits emerge earlier in the development of pAD. The PD dementia group performed worse on Category Fluency throughout the follow-up period, suggesting either that dementia is overlaid on this preexisting performance deficit or that this type of executive deficit is an early manifestation of dementia in PD. The pAD group performed more poorly throughout the follow-up period on SRT delayed recognition, consistent with a pAD-specific encoding deficit. We conclude that while pAD and PD dementia are similar in many respects, differences in their evolution support previous observation of unique features in the 2 dementias and suggest different underlying pathologies. (JINS, 1998, 4, 279–284.)
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Singh, Atar, Abhay Paliwal, and V. S. Pal. "Comparative study of electroencephalography changes in dementia." International Journal of Research in Medical Sciences 7, no. 8 (July 25, 2019): 2970. http://dx.doi.org/10.18203/2320-6012.ijrms20193379.
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Background: Dementia affected about 46 million people in 2015and this number will roughly triple within the next 40 years. In 2011 Alzheimer's Disease International argue that dementia has become one of the most urgent health and social care challenges of the 21st century and its potential effect on economies around the world is attracting global attention. Predicting dementia in the early stages would be essential for better treatment before significant brain damage occurs. Current difficulty is the lack of specific biomarkers. In some previous studies electroencephalography (EEG) have shown the capability to identify dementia early and even classify the degree of its severity at a lower cost for mass screening. The aim and objective of this study was to EEG changes in vascular dementia and Alzheimer's Disease Related Dementias (ADRD) or dementia where no cause is identifiable, to measure severity of dementia by using DSR scale in different subjects and to correlate DSRS with EEG findings.Methods: Study sample was the 40 patients in each three groups- Dementia patients without any known cause of dementia or Alzheimer's Disease Related Dementias (ADRD), Vascular dementia (VaD) patients and Controls (age and sex matched subjects scoring more than the cut of score on dementia Scale). Written informed consent will be taken after explaining the objectives and procedure of study in detail. EEG were recorded in eyes closed, on intermittent photic stimulation and hyperventilation, only eyes closed data was used in study and these data were entered in excel sheet and analyzed using SPSS Software, appropriate statistical test was applied wherever necessary.Results: Participants with VaD have theta waves while ADRD group have delta waves preponderance as compare to control.Conclusions: EEG can have additive value in diagnosing VaD as well as it alone can be helpful in differentiating healthy individuals from dementia patients.
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Morgan, Debra, Melanie Funk, Margaret Crossley, Jenny Basran, Andrew Kirk, and Vanina Dal Bello-Haas. "The Potential of Gait Analysis to Contribute to Differential Diagnosis of Early Stage Dementia: Current Research and Future Directions." Canadian Journal on Aging / La Revue canadienne du vieillissement 26, no. 1 (2007): 19–32. http://dx.doi.org/10.3138/1457-2411-v402-62l1.
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ABSTRACTEarly differential diagnosis of dementia is becoming increasingly important as new pharmacologic therapies are developed, as these treatments are not equally effective for all types of dementia. Early detection and differential diagnosis also facilitates informed family decision making and timely access to appropriate services. Information about gait characteristics is informative in the diagnostic process and may have important implications for discriminating among dementia subtypes. The aim of this review paper is to summarize existing research examining the relationships between gait and dementia, including gait classification systems and assessment tools, gait patterns characteristic of different dementias (Alzheimer's disease, vascular dementia, dementia with Lewy Bodies, and fronto-temporal dementia), and the utility of gait analysis in early-stage diagnosis. The paper concludes with implications for future research.
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Snowden, Julie S., David Neary, and David M. A. Mann. "Frontotemporal dementia." British Journal of Psychiatry 180, no. 2 (February 2002): 140–43. http://dx.doi.org/10.1192/bjp.180.2.140.
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BackgroundFrontotemporal dementia accounts for up to 20% of cases of dementia in the presenium, yet remains poorly recognised. Diagnostic criteria have been devised to aid clinical diagnosis.AimsTo provide an overview of clinical and pathological characteristics of frontotemporal dementia and its nosological status.MethodsThe review summarises consensus diagnostic criteria for frontotemporal dementia and draws on the authors'clinical experience of 300 frontotemporal dementia cases, and pathological experience of 50 autopsied cases.ResultsFrontotemporal dementia is characterised by pronounced changes in affect and personal and social conduct. Some patients also develop motor neuron disease. Mutations in the tau gene account for some but not all familial cases of frontotemporal dementia.ConclusionsFrontotemporal dementia is a focal form of dementia, which is clinically and pathologically distinct from other dementias. It represents an important model for understanding the functions of the frontotemporal lobes.
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Martins, Leonardo Tafarello, Ivan Abdalla Teixeira, Jerson Laks, and Valeska Marinho. "Recognizing Late Onset Frontotemporal Dementia with the DAPHNE scale: A case report." Dementia & Neuropsychologia 12, no. 1 (March 2018): 75–79. http://dx.doi.org/10.1590/1980-57642018dn12-010011.
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ABSTRACT Frontotemporal dementias are classically described as early onset dementias with personality and behavioral changes, however, late onset forms can also be found. Considering the paucity of information about late onset behavioral variant frontotemporal dementia and its challenging diagnosis, we present a case report of an 85-year-old woman with behavioral changes and slow progression to dementia who was first diagnosed as having bipolar disorder and then Alzheimer's disease. The Daphne scale provided a structured means to improve clinical diagnosis, also supported by characteristic features on MRI and SPECT, while CSF biomarkers ruled out atypical Alzheimer's disease.
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Matar, Elie, James M. Shine, Glenda M. Halliday, and Simon J. G. Lewis. "Cognitive fluctuations in Lewy body dementia: towards a pathophysiological framework." Brain 143, no. 1 (October 15, 2019): 31–46. http://dx.doi.org/10.1093/brain/awz311.
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Abstract Fluctuating cognition is a complex and disabling symptom that is seen most frequently in the context of Lewy body dementias encompassing dementia with Lewy bodies and Parkinson’s disease dementia. In fact, since their description over three decades ago, cognitive fluctuations have remained a core diagnostic feature of dementia with Lewy bodies, the second most common dementia in the elderly. In the absence of reliable biomarkers for Lewy body pathology, the inclusion of such patients in therapeutic trials depends on the accurate identification of such core clinical features. Yet despite their diagnostic relevance, cognitive fluctuations remain poorly understood, in part due to the lack of a cohesive clinical and scientific explanation of the phenomenon itself. Motivated by this challenge, the present review examines the history, clinical phenomenology and assessment of cognitive fluctuations in the Lewy body dementias. Based on these data, the key neuropsychological, neurophysiological and neuroimaging correlates of cognitive fluctuations are described and integrated into a novel testable heuristic framework from which new insights may be gained.
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Nabalamba, Alice, and Scott B. Patten. "Prevalence of Mental Disorders in a Canadian Household Population with Dementia." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 37, no. 2 (March 2010): 186–94. http://dx.doi.org/10.1017/s0317167100009914.
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Background:Medical and mental health comorbidity in Alzheimer's disease and other dementias presents difficult challenges for health service delivery. However, existing studies have been conducted in clinical samples and may not be informative for planning community services. The Canadian Community Health Survey (CCHS) provides an opportunity to characterize associations between dementias and mental and physical comorbidity in a household population aged 55 and over.Methods:Data were obtained from the 2005 CCHS-cycle 3.1. Weighted estimates for mood and anxiety disorders and other characteristics in Canadian population with dementia were calculated and were compared to those in people without the condition.Results:According to the CCHS, the prevalence of Alzheimer's disease and other dementia increases with age, more or less doubling every decade. The increase among women is monotonic, whereas among men in the household population the rate of dementia peaks at age 85-89 and falls thereafter. Mood and anxiety disorders were found to be substantially more frequent among people with Alzheimer's disease and other forms of dementia compared to those without the disease (mood disorders: 19.5% vs. 5.3% and anxiety disorders: 16.3% vs. 4.0%). Heart disease, stroke and obesity were associated with dementia as was a lower level of education. Furthermore, people with dementia were more likely than those without the disease to report activity restrictions.Conclusions:The high prevalence of mood and anxiety disorders in household population with Alzheimer's disease and other dementia demonstrates the burden of disease that is likely to worsen quality of life over time.
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Banks, Samantha A., Elia Sechi, and Eoin P. Flanagan. "Autoimmune encephalopathies presenting as dementia of subacute onset and rapid progression." Therapeutic Advances in Neurological Disorders 14 (January 2021): 175628642199890. http://dx.doi.org/10.1177/1756286421998906.
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The terms autoimmune dementia and autoimmune encephalopathy may be used interchangeably; autoimmune dementia is used here to emphasize its consideration in young-onset dementia, dementia with a subacute onset, and rapidly progressive dementia. Given their potential for reversibility, it is important to distinguish the rare autoimmune dementias from the much more common neurodegenerative dementias. The presence of certain clinical features [e.g. facio-brachial dystonic seizures that accompany anti-leucine-rich-glioma-inactivated-1 (LGI1) encephalitis that can mimic myoclonus] can be a major clue to the diagnosis. When possible, objective assessment of cognition with bedside testing or neuropsychological testing is useful to determine the degree of abnormality and serve as a baseline from which immunotherapy response can be judged. Magnetic resonance imaging (MRI) head and cerebrospinal fluid (CSF) analysis are useful to assess for inflammation that can support an autoimmune etiology. Assessing for neural autoantibody diagnostic biomarkers in serum and CSF in those with suggestive features can help confirm the diagnosis and guide cancer search in paraneoplastic autoimmune dementia. However, broad screening for neural antibodies in elderly patients with an insidious dementia is not recommended. Moreover, there are pitfalls to antibody testing that should be recognized and the high frequency of some antibodies in the general population limit their diagnostic utility [e.g., anti-thyroid peroxidase (TPO) antibodies]. Once the diagnosis is confirmed, both acute and maintenance immunotherapy can be utilized and treatment choice varies depending on the accompanying neural antibody present and the presence or absence of cancer. The target of the neural antibody biomarker may help predict treatment response and prognosis, with antibodies to cell-surface or synaptic antigens more responsive to immunotherapy and yielding a better overall prognosis than those with antibodies to intracellular targets. Neurologists should be aware that autoimmune dementias and encephalopathies are increasingly recognized in novel settings, including post herpes virus encephalitis and following immune-checkpoint inhibitor use.
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Jean, Léonie, Martine Simard, Robert van Reekum, and Diana E. Clarke. "Differential cognitive impairment in subjects with geriatric depression who will develop Alzheimer's disease and other dementias: a retrospective study." International Psychogeriatrics 17, no. 2 (May 9, 2005): 289–301. http://dx.doi.org/10.1017/s1041610205001511.
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Objective: The aim of this study was to retrospectively differentiate the cognitive profile of subjects with geriatric depression who will later be diagnosed with Alzheimer's disease (AD) from those who will be diagnosed with other dementias, and subjects who will remain with no dementia.Methods: Forty-four depressed patients admitted to a day hospital program for depression who participated in a historical cohort study were assessed after 7.5 years of follow-up. Fourteen of these subjects subsequently developed dementia: seven met the criteria for probable AD and seven met the criteria for dementias other than AD (Dementia-No-AD; D-NAD, such as dementia with Lewy bodies (DLB), vascular and mixed dementia). Thirty subjects remained without dementia (No Dementia, ND) at follow-up. The three groups were thus compared on their baseline cognitive performances on the six sections of the Mini-mental State Examination (MMSE) and on the five subscales of the Dementia Rating Scale (DRS).Results: An analysis of variance (ANOVA) and post-hoc Student–Newman–Keuls analyses with an alpha of p<0.05 revealed that the subjects who received a diagnosis of dementia at follow-up had previously had more impairment on tasks measuring attention and memory (DRS-MMSE) than those who did not develop dementia (AD=D-NAD<ND). Moreover, the future AD subjects could be differentiated on the basis of their difficulties on the MMSE-orientation subtest (AD<ND=D-NAD), whereas the future D-NAD subjects initially had more problems with executive functions (DRS) and MMSE-visuospatial abilities (D-NAD<AD=ND).Conclusion: The identification of early neuropsychological markers in elderly depressed patients highlights the need to evaluate this population broadly as soon as possible in the depression/dementia process in order to improve the prognosis.
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Wright, Christine E., and Paul L. Furlong. "Visual Evoked Potentials in Elderly Patients with Primary or Multi-Infarct Dementia." British Journal of Psychiatry 152, no. 5 (May 1988): 679–82. http://dx.doi.org/10.1192/bjp.152.5.679.
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Flash and pattern-reversal visual evoked potentials (VEP) were recorded in 35 elderly patients with dementia, and 19 controls of equivalent age. Dementia produced a slowing of the major positive (P2) component of the flash VEP but did not affect the latency of the flash P1 component or the P100 pattern-reversal component. This unusual type of abnormality was found in both primary and multi-infarct types of dementia, and has previously been found in primary presenile dementia. The results show that the VEP can be used for the diagnosis of multi-infarct, and primary presenile and senile dementias.