Journal articles on the topic 'Degree Name: Master of Clinical Research'
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Dudina, Oksana. "PECULIARITIES OF TRAINING MASTERS IN MEDICINE IN CHINISE UNIVERSITIES." Academic Notes Series Pedagogical Science 1, no. 192 (March 2021): 63–66. http://dx.doi.org/10.36550/2415-7988-2021-1-192-63-66.
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The article investigates and theoretically summarizes the peculiarities of training doctors at the master's level at the universities of ROC. Higher education in China is characterized by numerous changes due to the accumulation and adaptation of advanced successful experience in training specialists in different countries of the world. In this context, the property of scientists and educators of ROC concerning the organization of professional training of masters in medicine is of particular interest for Ukraine. Scientists are constantly searching for solutions and improving higher medical education in ROC. In the universities of the Republic of China, according to the field of study, the degree of master in medicine can be obtained as a professional degree and scientific degree. As a result, after completing the master's program in professional field, the master may work in positions such as senior physician, senior physician in health care, senior dentist, senior pharmaceutical, and the master in research field may work as the doctor-scientist, who carries out medical research as the main professional activity. The name of medical degrees is also different, for the professional field – clinical medicine, for the research field – preclinical medicine. Clinical medicine includes such areas of master's programs in medicine as health care, dentistry, pharmacological science; preclinical medicine includes clinical medicine, preventive medicine, dentistry, the science of human progress, the history of science and technology, biomedical engineering, social medicine and health management. The article examines the experience of implementing master's programs in medicine at higher educational institutions in China. The competence-based approach, forms and specialization of training in the organization of training and practicing students due to master's programs in medicine in ROC were determined.
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Cruz, Isabel Cristina Fonseca da. "The professional master in nursing: an new opportunity for brazilian nurse and an improvement in quality for the healthcare instituition." Online Brazilian Journal of Nursing 2, no. 1 (April 2, 2003): 1–2. http://dx.doi.org/10.17665/1676-4285.20034796.
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The role of nurse with Master Degree represents an challenge career opportunity for professional nurses. Currently, there are only 2 Professional Master in Nursing in Brazil, one is at São Paulo Federal University (SP) and the other, recently created, is at Fluminense Federal University (RJ). At the Fluminense Federal University, the Professional Master in Nursing includes course work and clinical experience in advanced health assessment, physiology, pathophysiology and pharmacology, as well as research, nursing theories, health promotion and disease prevention, healthcare policy, health and culture, diagnostic reasoning, and clinical decision making. In addition to course work, nurses are required to publish an original article and to produce a dissertation. The Professional Master in Nursing encompass a 2 year program of study with specialized clinical experiences. Advanced clinical education and experience based on scientifc evidences have been identified as requirements for practice as a nurse with Professional Master Degree. The nursing practice has recently expanded as a result of changes occurring in health care settings, including increased acuity of hospitalized patients, demands of management hability to reduce length of stay and to coordinate patient/family care. The scope of practice for nurses with a Professional Master Degree is broad-based and involves, mainly, providing advanced nursing care to patients and their families according to the practice setting and patient population. For example, it may comprehend also therapeutic procedure work, aspects of case management, discharge planning, monitoring quality standards, clinical research, undergraduate preceptorship, and inservice education of nursing staff for the instituition. The Professional Master in Nursing at the Fluminense Federal University will offer a unique advanced practice opportunity for nurses to develop their nursing careers and for healthcare institutions and nursing faculties to improve the quality of their services.
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Cruz, Isabel Cristina Fonseca da. "The Professional Master in Nursing at the Fluminense Federal University Nursing School will begin in 2004." Online Brazilian Journal of Nursing 2, no. 3 (October 20, 2004): 84–85. http://dx.doi.org/10.17665/1676-4285.20034893.
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The role of nurse with Master Degree represents an challenge career opportunity for professional nurses. Currently, there are only 2 Professional Master in Nursing in Brazil, one is at São Paulo Federal University (SP) and the other, recently approved by CAPES, is at Fluminense Federal University (RJ). At the Fluminense Federal University, the Professional Master in Nursing Program was designed for experienced nurses who is seeking preparation for advanced practice as a clinical specialist, educator, researcher, or administrator. It includes course work and clinical experience in advanced health assessment, physiology, pathophysiology and pharmacology, as well as research, nursing theories, health promotion and disease prevention, healthcare policy, health and culture, diagnostic reasoning, and clinical decision making. In addition to course work, nurses are required to publish an original article and to produce a dissertation. The Professional Master in Nursing encompass a 2 year program of study with specialized clinical experiences. Upon graduation, the nurse will have a base of knowledge in a specific area of nursing care; and can participate knowledgeably in research activity and application. Advanced clinical education and experience based on scientifc evidences have been identified as requirements for practice as a nurse with Professional Master Degree. The nursing practice has recently expanded as a result of changes occurring in health care settings, including increased acuity of hospitalized patients, demands of management hability to reduce length of stay and to coordinate patient/family care. The scope of practice for nurses with a Professional Master Degree is broad-based and involves, mainly, providing advanced nursing care to patients and their families according to the practice setting and patient population. For example, it may comprehend also therapeutic procedure work, aspects of case management, discharge planning, monitoring quality standards, clinical research, undergraduate preceptorship, and inservice education of nursing staff for the instituition. The Professional Master in Nursing at the Fluminense Federal University will offer a unique advanced practice opportunity for nurses to develop their nursing careers and for healthcare institutions and nursing faculties to improve the quality of their services.The Professional Master in Nursing at the Fluminense Federal University will be offered in March 2004. Do not miss the deadlines!
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Andrews, Abby, Katharine A. Wallis, and Felicity Goodyear-Smith. "Master of Primary Health Care degree: who wants it and why?" Journal of Primary Health Care 8, no. 2 (2016): 106. http://dx.doi.org/10.1071/hc15026.
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Abstract INTRODUCTION The Department of General Practice and Primary Health Care at the University of Auckland is considering developing a Master of Primary Health Care (MPHC) programme. Masters level study entails considerable investment of both university and student time and money. AIM To explore the views of potential students and possible employers of future graduates to discover whether there is a market for such a programme and to inform the development of the programme. METHODS Semi-structured interviews were conducted with 30 primary health care stakeholders. Interviews were digitally recorded, transcribed and analysed using a general inductive approach to identify themes. FINDINGS Primary care practitioners might embark on MPHC studies to develop health management and leadership skills, to develop and/or enhance clinical skills, to enhance teaching and research skills, or for reasons of personal interest. Barriers to MPHC study were identified as cost and a lack of funding, time constraints and clinical workload. Study participants favoured inter-professional learning and a flexible delivery format. Pre-existing courses may already satisfy the post-graduate educational needs of primary care practitioners. Masters level study may be superfluous to the needs of the primary care workforce. CONCLUSIONS Any successful MPHC programme would need to provide value for PHC practitioner students and be unique. The postgraduate educational needs of New Zealand primary care practitioners may be already catered for. The international market for a MPHC programme is yet to be explored.
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Bøttcher Berthelsen, Connie, Marianne Vamosi, and Bente Martinsen. "Camouflaging nursing research-related tasks in clinical practice–Experiences of newly-graduated masters of science in nursing." Journal of Nursing Education and Practice 10, no. 3 (November 25, 2019): 42. http://dx.doi.org/10.5430/jnep.v10n3p42.
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Objective: To explore and describe how newly-graduated Masters of Science in Nursing experienced engaging in nursing research-related tasks in daily clinical practice.Methods: Fifteen nurses withholding a Masters of Science in Nursing degree were recruited from our longitudinal cohort study and interviewed six months after graduation in December 2016 (n = 10) and in December 2017 (n = 5), respectively. Data were analysed using Graneheim and Lundmann’s qualitative manifest and latent content analysis. Lincoln and Guba’s four criteria of trustworthiness were followed.Results: The main theme of the overall interpretation was Camouflaging nursing research-related tasks in clinical practice. The main theme describe the Master of Science in Nursing graduates as highly motivated to use their new academic skills in clinical practice and how they have to hide their engagement in research due to the barriers, which are outlined in the three themes: the position as time restrainer, the management as gatekeeper, and the nursing culture as norm setter.Conclusions: The study contributes with knowledge on how the Master of Science in Nursing graduates struggle to use their academic skills in clinical practice and how they felt the need to camouflage their commitment in research because it was not well reputed among their colleagues.
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Sun, K., P. Charpentier, P. M. Nadkarni, and C. A. Brandt. "Integration of Web-based and PC-based Clinical Research Databases." Methods of Information in Medicine 43, no. 03 (2004): 287–95. http://dx.doi.org/10.1055/s-0038-1633870.
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SummaryWe have created a Web-based repository or data library of information about measurement instruments used in studies of multi-factorial geriatric health conditions (the Geriatrics Research Instrument Library – GRIL) based upon existing features of two separate clinical study data management systems. GRIL allows browsing, searching, and selecting measurement instruments based upon criteria such as keywords and areas of applicability. Measurement instruments selected can be printed and/or included in an automatically generated standalone microcomputer database application, which can be downloaded by investigators for use in data collection and data management. Methods: Integration of database applications requires the creation of a common semantic model, and mapping from each system to this model. Various database schema conflicts at the table and attribute level must be identified and resolved prior to integration. Using a conflict taxonomy and a mapping schema facilitates this process. Results: Critical conflicts at the table level that required resolution included name and relationship differences. Conclusions: A major benefit of integration efforts is the sharing of features and cross-fertilization of applications created for similar purposes in different operating environments. Integration of applications mandates some degree of metadata model unification.
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Duma, Narjust, Urshila Durani, Cynthia Brooke Woods, Lionel Aurelien Kankeu Fonkoua, Joselle Cook, Christopher Wee, Harry E. Fuentes, et al. "Evaluating unconscious bias: Speaker introductions at an international oncology conference." Journal of Clinical Oncology 37, no. 15_suppl (May 20, 2019): 10503. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.10503.
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10503 Background: Gender bias can be reinforced through the use of gender-subordinating language and differences in the forms of address. We examined how professional titles were used during speakers’ introductions at the American Society of Clinical Oncology (ASCO) Annual Meeting. Methods: A retrospective observational study of video-archived speaker introductions at the 2017 and 2018 ASCO annual meetings was conducted. Data were extracted by mixed-gender coders. Professional address was defined as professional title followed by full name or last name. Multivariable logistic regressions were used to identify factors associated with the form of address. Results: 2511 videos were reviewed and 812 met inclusion criteria. Regarding speakers’ characteristics, 530 (65%) were non-Hispanic white (NHW), 743 (92%) held a MD or MD-PhD degree, and 484 (60%) were an associate or full professor. Female speakers were less likely to receive a professional address compared to male speakers (61% vs. 81%, p < 0.001). Female speakers were more likely to be introduced by first name only (17% vs. 3%, p < 0.001). Males were less likely to use a professional address when introducing female speakers compared to male speakers (53% vs. 80%, p < 0.01). No gender differences in professional address were observed for female introducers (p = 0.13). Male introducers were more likely to address female speakers by first name only compared to female introducers (24% vs. 7%, p < 0.01). In a multivariable regression including gender, race, degree, and academic rank, male speakers were more likely to receive a professional address compared to female speakers (OR: 2.67, 95%CI: 1.81-3.94, p < 0.01). Black speakers of both genders were less likely to receive a professional address compared to NHW (OR: 0.10, 95%CI: 0.01-0.53, p < 0.01). Female gender was a predictor for a non-professional form of address (first name only) (OR: 9.50, 95%CI: 4.38-20.62, p < 0.01). Conclusions: When introduced by men, female speakers were less likely to receive a professional address and more likely to be introduced by first name only compared to male speakers. Selective use of forms of address may strengthen gender bias; more research is needed to explore the causes of this disparity and its influence.
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Koçak, Funda, and Oğuz Özbek. "Views of postgraduate students regarding research ethics in Turkey." Journal of Human Sciences 13, no. 2 (August 22, 2016): 3560. http://dx.doi.org/10.14687/jhs.v13i2.3780.
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This research aimed to examine the level of knowledge of master and doctorate students regarding scientific research ethics and the frequency of scientific deception identification in scientific publications. The research was conducted using descriptive methods. The group under examination consisted of 112 randomly chosen students who pursued their postgraduate degree in physical education and sports fields. The validity and reliability were determined in the framework of this study. Item total correlation and factor analyses were conducted for the construct validity of the assessment tool. The Alpha Coefficient, which was calculated for the scale reliability as .96, indicated the scale is valid and reliable. The Shapiro-Wilks test was also conducted to determine whether the data were normally distributed. Because the data did not exhibit a normal distribution, a non-parametric Mann-Whitney U test was utilised. “Writing more than one article using the same data”, “citing without providing a reference”, “reporting findings that are only consistent with expectations”, “publishing someone else’s ideas without providing references as if they are one’s own”, “presenting the same research in more than one conference or symposium”, and “publishing the same research in more than one journal” are the most non-ethical behaviours perceived in scientific research. All of the participants indicated that “presenting falsified findings of research and publishing someone else’s research with own name” represent non-ethical behaviours. According to the research results, “citing without providing a reference” and “writing more than one article using the same data” were the most unethical behaviours identified in scientific studies.
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Rodriguez, C., S. Suominen, K. Van Landuyt, J. Farhadi, M. Hamdi, E. Santamaria, F. Kolb, et al. "The new paradigm on microsurgical education: the international master degree on reconstructive microsurgery." Issues of Reconstructive and Plastic Surgery 24, no. 1 (May 20, 2021): 81–91. http://dx.doi.org/10.52581/1814-1471/76/10.
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Microsurgery (MS) is a discipline addressed by many specialties and it is our interest to be able to carry out a pedagogical assessment of the Master Degree in Reconstructive Microsurgery (MRM) as a training program in MS.The MRM is a hybrid, blended program (virtual and face-to-face), developed in 12 modules, over a 2-year duration, which completes 2625 hours. This program is directed by recognized professors in the discipline from different parts of the World and enrolls 35 students per edition.The program reserves 35% of the places for students from emerging countries. Once each of the modules has been received and the exams passed, the students will undergo a period of clinical immersion in the reference centers around the world and after defending the research project they will be able to receive the distinction of the Master granted by the Autonomous University of Barcelona (UAB).There have been 11 editions of MRM since 2009 without interruption, with an enrollment of 400 students, 83% received the MRM degree. 65% work as Microsurgeons. 60% were Men and 40%, Women. 32% have become MS leaders in each region.We consider that the MRM is a solid, reproducible and adaptable program that guarantees each one of the pedagogical aspects. The program is unique and brings together all the qualities so that students have the necessary tools and thus make a safe start in MS.
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Xi, Rui, Yu Wang, Aoli Huang, and Baojie Zhao. "Phenomenological Study on the Study Experience of Part-Time Nursing Postgraduates." Journal of Healthcare Engineering 2022 (February 23, 2022): 1–9. http://dx.doi.org/10.1155/2022/1948691.
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In this paper, we have explored the experience of studying part-time nursing master degree students and provided a basis for improving the training of domestic part-time nursing master degree students. Using phenomenological research methods, we have conducted face-to-face and semistructured interviews with 14 part-time nursing graduate students, including postgraduate motivation, obstacles, gains, and expectations after postgraduate study. Part-time nursing master’s graduate students are mostly motivated by promotion, self-improvement, solving clinical problems, and role models; barriers to entry include role conflicts, time pressure, economic pressure, curriculum settings that cannot meet needs, unclear responsibilities for training process management, and personal value (cannot reflect, etc.). Study gains include enhancing scientific research confidence, stimulating learning interest, and increasing professional identity. In the training of part-time nursing master’s students, we should correctly guide students’ learning motivation, mobilize social support, and solve students’ learning obstacles. The curriculum of part-time nursing master’s students should be targeted, along with establishing a training management system jointly directed by the training unit and the employer, improving the career planning of nursing master’s students, and making a good connection with the training of senior practical nurses.
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Cruz, Isabel Cristina Fonseca da. "Online Brazilian Journal of Nursing." Online Brazilian Journal of Nursing 3, no. 3 (December 3, 2004): 1–2. http://dx.doi.org/10.17665/1676-4285.20044924.
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This editorial is devoted to celebrate the anniversary of the Aurora de Afonso Costa School of Nursing (AACSN), at Fluminense Federal University (FFU). Rich in history, the AACSN celebrates its sixtieth year in 2004 meeting the health challenges of our developing country. An undergraduate program was first offered by the School of Nursing in 1944. The AACSN alumni impact the State of Rio de Janeiro, the nation and the world in health care delivery because they are prepared to be highly educated nurse leaders in research, teaching, training and care. So, practicing nurses play an essential role in linking the findings of research with the communities in which they work.The AACSN completed 60 years and will continue with the primary goals of excellence in nursing education, research and practice, as well as a commitment to service. In 1979, the AACSN initiated its first graduate experience: a nursing service administration certificate course, lato sensu graduate program, leading to a specialist degree. The School added programs in succeeding years that were created and coordinated by Dr. Isabel Cruz: Health Promotion (1994), Intensive Care, Renal Substitutive Therapies (2000), and Professional Master of Science (2003).We invite you to learn more about our School's three major departments, the Master Degree Program, and our Antonio Pedro University Hospital. Please, visit the Jane da Fonseca Proença Nursing Library.Read the NEPAE-NESEN the newsletter published by 2 School of Nursing´s research groups and check out the Online Brazilian Journal of Nursing, a scholarly peer-reviewed journal with free-access, for an inside look at the School of Nursing Professional Master´s Degree Program and our research production.The AACSN nursing faculty provide education and research training in the social, behavioral, and biological sciences focused on health, illness, and health care, and offer innovative teaching-learning strategies:a. on-city “labs” that prepare students from culturally diverse backgrounds for real life hospital or community clinical situations;b. evidenced-based practice integrated into campus classroom discussions;c. and student cultural emersion in Oriximiná - FFU campus, at Amazonian region.As you can see, the AACSN undergraduate (bachelor degree) and graduate (master´s degree) programs prepare students from the beginning generalist to the advanced practice nurse and the nurse scientist. The AACSN nursing research is recognized nationally for answering questions related to African-Brazilian health and institutional racism, women and children topics (Rosalda Paim, RN, PhD, Full Professor [former]), mental health, and other themes. The AACSN nursing faculty and students benefit the public, the profession, and the University through active individual and group involvement in service activities, promoting and demonstrating excellence in professional nursing practice. Taking advantage of its long history as a part of the Fluminense Federal University, the AACSN will continue to work cooperatively with other health professionals on campus, nationally, and internationally in its search for excellence in teaching, research, practice, and public service.Happy anniversary to the AACSN and a happy new year for all!
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Hailpern, Susan M. "Teaching Statistics to Physicians using Stata." Stata Journal: Promoting communications on statistics and Stata 5, no. 2 (June 2005): 248–58. http://dx.doi.org/10.1177/1536867x0500500209.
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The Clinical Research Training Program (CRTP) at the Albert Einstein College of Medicine at Yeshiva University is a two-year program for physicians leading to a Master of Science degree in Clinical Research Methods. Beginning in July 2004, the program began teaching data analysis using Stata 8 in order to better meet the advanced statistical needs of the students. This paper details the structure and content of the course, how Stata was introduced, and the problems we encountered. Student comments and suggestions on future enhancements to Stata are included. Although challenging, our first semester teaching Stata was a success: the students all learned Stata and, more importantly, continued to use it for the analysis of their own research data after the course was complete.
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Strom, Brian L., Thomas O. Kelly, Sandra A. Norman, John T. Farrar, Stephen E. Kimmel, Ebbing Lautenbach, and Harold I. Feldman. "The Master of Science in Clinical Epidemiology Degree Program of the Perelman School of Medicine at the University of Pennsylvania: A Model for Clinical Research Training." Academic Medicine 87, no. 1 (January 2012): 74–80. http://dx.doi.org/10.1097/acm.0b013e31823ab5c2.
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Wong, Mitchell D., Lourdes Guerrero, Tamer Sallam, Joy S. Frank, Alan M. Fogelman, and Linda L. Demer. "Outcomes of a Novel Training Program for Physician-Scientists: Integrating Graduate Degree Training With Specialty Fellowship." Journal of Graduate Medical Education 8, no. 1 (February 1, 2016): 85–90. http://dx.doi.org/10.4300/jgme-d-15-00135.1.
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ABSTRACT Background Although physician-scientists generally contribute to the scientific enterprise by providing a breadth of knowledge complementary to that of other scientists, it is a challenge to recruit, train, and retain physicians in a research career pathway. Objective To assess the outcomes of a novel program that combines graduate coursework and research training with subspecialty fellowship. Methods A retrospective analysis was conducted of career outcomes for 123 physicians who graduated from the program during its first 20 years (1993–2013). Using curricula vitae, direct contact, and online confirmation, data were compiled on physicians' subsequent activities and careers as of 2013. Study outcomes included employment in academic and nonacademic research, academic clinical or private practice positions, and research grant funding. Results More than 80% of graduates were actively conducting research in academic, institutional, or industrial careers. The majority of graduates (71%) had academic appointments; a few (20%) were in private practice. Fifty percent had received career development awards, and 19% had received investigator-initiated National Institutes of Health (NIH) R01 or equivalent grants. Individuals who obtained a PhD during subspecialty training were significantly more likely to have major grant funding (NIH R series or equivalent) than those who obtained a Master of Science in Clinical Research. Trainees who obtained a PhD in a health services or health policy field were significantly more likely to have research appointments than those in basic science. Conclusions Incorporation of graduate degree research, at the level of specialty or subspecialty clinical training, is a promising approach to training and retaining physician-scientists.
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ZHOU, Ying. "Initial Research of Education Management of the Clinical Medicine Professional Master Degree which is Independently Established by Local General Medical Colleges in China." Creativity and Innovation 4, no. 6 (2020): 72–92. http://dx.doi.org/10.47297/wspciwsp2516-252710.20200406.
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Menck, Kerstin, Darius Wlochowitz, Astrid Wachter, Lena-Christin Conradi, Alexander Wolff, Andreas Scheel, Ulrike Korf, et al. "High-Throughput Profiling of Colorectal Cancer Liver Metastases Reveals Intra- and Inter-Patient Heterogeneity in the EGFR and WNT Pathways Associated with Clinical Outcome." Cancers 14, no. 9 (April 21, 2022): 2084. http://dx.doi.org/10.3390/cancers14092084.
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Seventy percent of patients with colorectal cancer develop liver metastases (CRLM), which are a decisive factor in cancer progression. Therapy outcome is largely influenced by tumor heterogeneity, but the intra- and inter-patient heterogeneity of CRLM has been poorly studied. In particular, the contribution of the WNT and EGFR pathways, which are both frequently deregulated in colorectal cancer, has not yet been addressed in this context. To this end, we comprehensively characterized normal liver tissue and eight CRLM from two patients by standardized histopathological, molecular, and proteomic subtyping. Suitable fresh-frozen tissue samples were profiled by transcriptome sequencing (RNA-Seq) and proteomic profiling with reverse phase protein arrays (RPPA) combined with bioinformatic analyses to assess tumor heterogeneity and identify WNT- and EGFR-related master regulators and metastatic effectors. A standardized data analysis pipeline for integrating RNA-Seq with clinical, proteomic, and genetic data was established. Dimensionality reduction of the transcriptome data revealed a distinct signature for CRLM differing from normal liver tissue and indicated a high degree of tumor heterogeneity. WNT and EGFR signaling were highly active in CRLM and the genes of both pathways were heterogeneously expressed between the two patients as well as between the synchronous metastases of a single patient. An analysis of the master regulators and metastatic effectors implicated in the regulation of these genes revealed a set of four genes (SFN, IGF2BP1, STAT1, PIK3CG) that were differentially expressed in CRLM and were associated with clinical outcome in a large cohort of colorectal cancer patients as well as CRLM samples. In conclusion, high-throughput profiling enabled us to define a CRLM-specific signature and revealed the genes of the WNT and EGFR pathways associated with inter- and intra-patient heterogeneity, which were validated as prognostic biomarkers in CRC primary tumors as well as liver metastases.
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Ramani Bai Gopinath, V., S. H. Dhavarpanah, G. Kangadharan, and R. Ruzaimah. "Fuzzy Logic Intelligent system for an Automatic medical waste segregation." Journal of Physics: Conference Series 2040, no. 1 (October 1, 2021): 012004. http://dx.doi.org/10.1088/1742-6596/2040/1/012004.
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Abstract AUTOM is an acronym given to a commercially designed automatic waste disposal master tool for medical laboratories and clinical waste separation through this research study. In this research, a fuzzy rule-based system is designed which can segregate 24 different waste types which are selected from 8 more common medical waste groups. In the proposed system, after capturing each frame some pre-processing operations are done, features are extracted, fuzzy parameters, fuzzy terms and fuzzy rules are determined and finally a rule with a maximum certification degree is fired. In the designed fuzzy rule-based system 24 roles corresponding to the 24 detectable objects exist, 14 fuzzy parameters are defined, and a maximum of 3 fuzzy terms for each fuzzy parameter have been considered. The system is flexible on different light conditions, view degree of the camera, and 360° object rotation. Our experiments on a real environment and using both new and used wastes have shown up to 94% of better performance of the system developed.
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Kosenko, V. M. "THE POTENTIAL CAPACITY OF THE “INFECTION CONTROL” DISCIPLINE IN THE FORMATION OF RESPONSIBLE ATTITUDE TO THE PATIENT SAFETY AMONG MASTER NURSES IN THE PROCESS OF PROVIDING MEDICAL AND PREVENTIVE CARE." Медична освіта, no. 2 (August 5, 2021): 138–42. http://dx.doi.org/10.11603/me.2414-5998.2021.2.11961.
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In the article we have analyzed the significance and importance of the “Infection Control” discipline in pursuing a master’s degree in nursing. The article states that the master nurse is the lead organizer and executor of activities related to the creation of a safe hospital environment, while the correctness and completeness of the actions at the workplace depends on the depth of theoretical knowledge and sophistication of practical skills. The paper specifies the general and occupational competencies, forms and methods of conducting lectures and practical sessions, describes the expected results of training, indicates interdisciplinary integration, draws attention to the problems of honesty in the performance of autonomous and individually research work by the seekers of higher education. It is noted that the practical health care needs such a master nurse, who not only possesses thorough professional knowledge, but also is capable to act clearly and quickly in an emergency, perfectly master up-to-date techniques of preventing, in particular, the healthcare-associated infections through the developed clinical judgment. It is the competency based potential capacity of the “Infection Control” academic discipline that makes it possible to realize these tasks. The priority area of improving the educational process is its practical orientation and significance.
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Fathunikmah, Fathunikmah, and Rafida Rafida. "Uji Coba Model “My” Terhadap Keterampilan Klinis Penjahitan Perineum Derajat Dua." SEAJOM: The Southeast Asia Journal of Midwifery 4, no. 1 (March 20, 2018): 14–21. http://dx.doi.org/10.36749/seajom.v4i1.23.
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Good clinical skills should be preceded by good skills-lab as well. Therefore, before being used for practice in the treatment room, teaching aids should be used repeatedly so that health workers can master the desired competencies. The purpose of this research was to determine the effectiveness and efficiency of perineal repair model to the clinical skill learning of second degree perineum repair at Camar Room I and II of Arifin Achmad Hospital of Pekanbaru in 2017. This qualitative used a phenomenological design. The research was conducted from February to July 2017. The informants in this research were all midwives who worked in the study site amounted to 20 people. Data were collected by FGD method. The result of the research was that this model was quite realistic when grafted with pelvic model. As a second-grade perineal wound repair material, this model can also be categorized as realistic because it could be sewn on 1 cm of wound peaks, bleary, and subcuticular. The durability of this model was reviewed as low-cost with its good durability and safety.
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Green, R. N., R. L. Trowbridge, and K. Klinka. "Towards a Taxonomic Classification of Humus Forms." Forest Science 39, suppl_1 (February 1, 1993): a0001—z0002. http://dx.doi.org/10.1093/forestscience/39.s1.a0001.
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Abstract A two-category taxonomic classification and a methodology for field description are proposed to aid in consistent identification and interpretation of humus forms for ecosystem research, surveys, and management. The classification uses the nomenclature principles of the U.S. soil taxonomy and the master organic horizon designations of the Canadian system of soil classification. It includes humus form taxa that have been recognized in Europe and North America. Recognized taxa are defined on the basis of observable and easily measurable morphological properties. Three taxa, Mor, Moder, and Mull, are recognized at the order level and are differentiated according to the type of F horizon and the relative prominence of organic-enriched A horizons. These reflect principal differences in the nature and rate of decomposition processes. Names of the 16 taxa at the lower, group level are created by adding formative elements to the name of the order. For example, groups of the Mor order are differentiated according to the relative thickness of F and H horizons (Hemimors and Humimors); degree of humification in the H horizon (Resimors); content of decaying wood (Lignomors); and moisture regime (Hydromors, Fibrimors, and Mesimors). Phases can be formed for any taxon to recognize important morphological properties that deviate from the taxonomic differentiae. Keys to the recognized taxa and descriptions of representative humus form profiles for each group are provided to assist in identification. Methods for describing, sampling, and surveying humus forms are presented to facilitate field examinations and subsequent studies.
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Rath, Badal B. "Maruti Ertiga launch in India by new category creation." Emerald Emerging Markets Case Studies 3, no. 6 (November 14, 2013): 1–8. http://dx.doi.org/10.1108/eemcs-08-2012-0147.
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Subject area Marketing. Sub subjects: customer segmentation, targeting, positioning and new product launch strategies. Study level/applicability This case can be taught at degree and master level management programmes including distance education mode in business schools having marketing management as one of the subjects. Case overview Maruti Suzuki a leading global Japanese car manufacturer recently launched a new multi utility passenger car with the brand name Ertiga. Ertiga was launched by Maruti Suzuki as life utility vehicle (LUV) using lifestyle categorization instead of using car categorization to position Ertiga using LUV theme. This new category created called LUV is in car categorization between high end hatchbacks and multi utility vehicles/sedans. This case highlights how Maruti Suzuki through effective market research was able to identify a new category and also create and offer a car to the Indian market. This case covers some of the innovative promotional strategies like in film promotions and brand placements which was used to promote Ertiga in India. Expected learning outcomes The case is designed to enable students to understand the concept of segmentation, targeting, and positioning about the various products launch strategies companies adopt in the emerging markets. Also this case covers the marketing mix concepts and how it was adopted during the Ertiga launch in India. Supplementary materials Teaching notes are available for educators only. Please contact your library to gain login details or email: support@emeraldinsight.com to request teaching notes.
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Aji, Arif Sabta, Yusrawati Yusrawati, Safarina G. Malik, and Nur Indrawaty Lipoeto. "Pre-Pregnancy Maternal Nutritional Status and Physical Activity Levels During Pregnancy Associated with Birth Size Outcomes in Minangkabau Women, Indonesia." Current Developments in Nutrition 4, Supplement_2 (May 29, 2020): 931. http://dx.doi.org/10.1093/cdn/nzaa054_003.
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Abstract Objectives To analyse the association between maternal physical activity status and birth size outcomes and whether other determinants of confounding variable such as pre-pregnancy BMI (PP BMI) and gestational weight gain (GWG) during pregnancy affect birth size outcomes. Methods A prospective birth cohort study. Subject's PAL was measured at the first trimester (T1) and third trimester (T3) during pregnancy. Birth size outcomes were measured immediately after birth. Results The analyses included 183 mother and infant pairs with a mean newborn birth weight of 3211.75 ± 434.70 g. Pregnant women at T3 had two times lower physical activity than T1 of pregnancy (OR, 2.18; CI, 1.044–4.57; P = 0.045). Maternal PAL at T1 and T3 were in sedentary level (74.30% and 77%, respectively). There was no association between PP BMI and physical activity level during pregnancy. We found no significant association between PAL during pregnancy and birth size outcomes (P > 0.05 for all comparisons). However, we had a significant association with birth weight after our confounder adjustment (P = 0.032). There was a significant interaction between maternal PAL and PP BMI on birth weight and head circumference (Pinteraction < 0.05). Conclusions Our study provides evidence that neither maternal physical activity status nor pre-pregnancy BMI in the prenatal period are associated with birth size outcomes (birthweight, birth length, and head circumference). Funding Sources This research was supported by the Ministry of Research, Technology and Higher Education of the Republic of Indonesia (Menristekdikti) with project name The Research of Master Program Leading to Doctoral Degree for Excellent Students (PMDSU Batch-2) in the year of 2018 (Grant No: 050/SP2HL/LT/DRPM/2018) and Indonesian Danone Institute Foundation (Grant No: 007/ROG-D/IDIF/X2016). The views expressed herein are those of the individual authors and do not necessarily reflect those of Indonesia's Danone Institute Foundation (IDIF).
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Dizon, Don S., Jennifer S. Gass, Christina Bandera, Sherry Weitzen, and Melissa Clark. "Does One Person Provide It All? Primary Support and Advanced Care Planning for Women With Cancer." Journal of Clinical Oncology 25, no. 11 (April 10, 2007): 1412–16. http://dx.doi.org/10.1200/jco.2006.09.0845.
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Purpose We challenged a common clinical assumption that female cancer patients designate the same individual who provides them with primary support in advanced care planning roles. Patients and Methods During 6 months, we conducted a survey of female cancer patients seen in a women's oncology program. Women were asked to name their health care proxy (HCP), emergency contact (EC), and primary support, and to define their own meaning of primary support. The person identified by chart review (C-ID) as that patient's primary contact was also abstracted. The frequency that the same person served all three roles was determined. Concordance between the C-ID and surveyed responses was calculated. Results Two hundred fifteen (98%) of 219 women agreed to participate. The median age was 58 years (range, 29 to 85 years). Women were surveyed a median of 14.3 months since diagnosis (range, 0.3 to 214 months). Although 80.4% of women surveyed named a first-degree relative to fill all three roles, only 56.7% of respondents identified the same individual for each of these roles. For those in relationships, 54% named their partner in all three roles. The majority of women characterized support as emotional (46.7%) or as emotional and structural (22.6%). Concordance was strongest between the C-ID and both EC and HCP. Conclusion More than 40% of women with cancer in our sample did not name the same person for support and for advanced care planning roles. We also discovered a lack of uniformity in definitions of primary support. The implications of these findings on decision making and outcomes in women with cancer require additional study.
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Caba, Bogdan, Ioannis Gardikiotis, Ionut Topala, Ilarion Mihaila, Cosmin Teodor Mihai, Catalina Luca, Sorin Pasca, et al. "Cold Atmospheric Plasma, Platelet-Rich Plasma, and Nitric Oxide Synthesis Inhibitor: Effects Investigation on an Experimental Model on Rats." Applied Sciences 12, no. 2 (January 7, 2022): 590. http://dx.doi.org/10.3390/app12020590.
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The evolution of reconstructive methods for defects of the human body cannot yet replace the use of flap surgery. Research is still preoccupied with the ideal techniques for offering the best chances of survival of the flaps. In our study, we investigated the effects of cold atmospheric plasma (CAP), N-nitro-L-arginine methyl ester (L-NAME), and platelet-rich plasma (PRP) injectable solutions on flap survival using an in vivo model. Twenty-four Wistar rats (four groups) had the McFarlane flap raised and CAP, L-NAME, and PRP substances tested through a single dose subcutaneous injection. The control group had only a saline solution injected. To the best of our knowledge, this is the first study that evaluated a CAP activated solution through injection on flaps. The flap survival rate was determined by clinical examination (photography documented), hematology, thermography, and anatomopathological tests. The image digital analysis performed on the flaps showed that the necrosis area (control—49.64%) was significantly lower for the groups with the three investigated solutions: CAP (14.47%), L-NAME (18.2%), and PRP (23.85%). Thermography exploration revealed less ischemia than the control group on the CAP, L-NAME, and PRP groups as well. Anatomopathological data noted the best degree of angiogenesis on the CAP group, with similar findings on the L-NAME and PRP treated flaps. The blood work did not indicate infection or a strong inflammatory process in any of the subjects. Overall, the study shows that the CAP activated solution has a similar (better) impact on the necrosis rate (compared with other solutions with known effects) when injected on the modified dorsal rat skin flap, and on top of that it can be obtained fast, in unlimited quantities, non-invasively, and through a standardized process.
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Dewidar, Meyer, Dooley, and Meindl-Beinker. "TGF-β in Hepatic Stellate Cell Activation and Liver Fibrogenesis—Updated 2019." Cells 8, no. 11 (November 11, 2019): 1419. http://dx.doi.org/10.3390/cells8111419.
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Liver fibrosis is an advanced liver disease condition, which could progress to cirrhosis and hepatocellular carcinoma. To date, there is no direct approved antifibrotic therapy, and current treatment is mainly the removal of the causative factor. Transforming growth factor (TGF)-β is a master profibrogenic cytokine and a promising target to treat fibrosis. However, TGF-β has broad biological functions and its inhibition induces non-desirable side effects, which override therapeutic benefits. Therefore, understanding the pleiotropic effects of TGF-β and its upstream and downstream regulatory mechanisms will help to design better TGF-β based therapeutics. Here, we summarize recent discoveries and milestones on the TGF-β signaling pathway related to liver fibrosis and hepatic stellate cell (HSC) activation, emphasizing research of the last five years. This comprises impact of TGF-β on liver fibrogenesis related biological processes, such as senescence, metabolism, reactive oxygen species generation, epigenetics, circadian rhythm, epithelial mesenchymal transition, and endothelial-mesenchymal transition. We also describe the influence of the microenvironment on the response of HSC to TGF-β. Finally, we discuss new approaches to target the TGF-β pathway, name current clinical trials, and explain promises and drawbacks that deserve to be adequately addressed.
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Fujimaki, Takamitsu, and Akira Matsuno. "NCOG-61. A CASE OF LONG TERM SURVIVOR OF DISSEMINATED AND RELAPSED GERMINOMA. EIGHTEEN YEARS OF FOLLOW UP." Neuro-Oncology 22, Supplement_2 (November 2020): ii143. http://dx.doi.org/10.1093/neuonc/noaa215.599.
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Abstract Germinomas will respond to first-line treatment in general, but prognoses of disseminated and/or relapsed disease are sometimes poor and detailed course of those patients are not well documented. Here we report one of such cases. PATIENT: A 35-year-old man (at the time of abstract submission) initially had polyuria at the age of 15 and anorexia at 16. At the age of 17, MRI showed neurohypophyseal and disseminated tumor along lateral ventricular walls. He was diagnosed to have germinoma by partial resection of the tumor. ICE (Ifosfamide, Cisplatin, Etoposide) chemotherapy was given followed by 24 Gy whole ventricular irradiation. The tumor was well controlled for 22 months. However despite maintenance ICE chemotherapy, the tumor relapsed along the ventricular walls. With simultaneous BEP (Bleomycin, Etoposide, Cisplatin) chemotherapy and 40 Gy whole neuroaxis irradiation, all the tumor disappeared and he remains in complete remission now. He is receiving hormone replacement therapy. Eight years after the initial surgery, an MRI showed cavernous angioma in the cerebellum and the number has been increasing in follow-up scans. Asymptomatic minor bleeding occurred 14 and 15 years after the initial surgery. On MRA, no vasculopathy on major vessels has been identified. His wife gave birth to his first child through infertility treatment, when he was 34. He finished graduate school to obtain master degree and working as a company employee. CONCLUSION: Germinoma is a disease that can cause long-term survival even after recurrence. However, complications may occur and multimodality approaches are needed for the survivors.
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Woodard, Wiremu, and John O'Connor. "Entering the Void: Exploring the Relationship Between the Experience of Colonisation and the Experience of Self for Indigenous Peoples of Aotearoa, and the Implications for Psychotherapeutic Clinical P." Ata: Journal of Psychotherapy Aotearoa New Zealand 23, no. 2 (February 27, 2020): 89–112. http://dx.doi.org/10.9791/10.9791/ajpanz.2019.09.
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This paper explores the relationship between the experience of colonisation and the experience of self for Indigenous peoples of Aotearoa. As we celebrate the formation of Waka Oranga in 2007, and its work in the years since, the publication of this paper is particularly fitting, drawing as it does on research originally undertaken at the time of the roopu’s formation. It is based on the lead author’s 2008 Master of Psychotherapy dissertation research in which he undertook a modified systematic literature review located within a kaupapa Māori research framework, in order to explore the experience of self for Indigenous peoples of Aotearoa and its relationship to colonisation. The paper examines the process of racialisation: The construction and resulting interiorisation of Indigenous peoples as Other’. The paper contends that this process has the effect of disrupting indigenous ontologies creating a divided and alienated experience of self for Indigenous peoples. Within Aotearoa, the phenomenon of whakamā and mate Māori are hypothesised as the indigenous experience of this alienated and divided self. The paper suggests that arguably all psychological distress for Indigenous peoples of Aotearoa arise to some degree fromthese experiences. Implications for psychotherapy are considered. Psychotherapy and psychotherapists are challenged to re-evaluate both the underlying positivist conceptualisations of self, and ongoing processes of colonisation, in order that they may be more fully equipped to effectively work alongside indigenous communities in Aotearoa.
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Mansmann, Ulrich Robert, Gabriele Woelke, Jutta Engel, and Juergen Stausberg. "Strenghening and protecting families: How to handle the familial colorectal cancer risk—A prospective observational study in Upper Bavaria." Journal of Clinical Oncology 32, no. 3_suppl (January 20, 2014): 427. http://dx.doi.org/10.1200/jco.2014.32.3_suppl.427.
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427 Background: Lynch defines patients with familial colorectal cancer (CRC) risk as those with two or more first- or second-degree relatives (or both) with CRC. They make up about 20 percent of all CRC patients. Also, first degree relatives of CRC patients have an increased CRC risk. It is our goal to create population based data on familial CRC risk in a German population. Methods: Incident CRC cases in Upper Bavaria are collected and their family trees constructed. The patient’s relatives are documented by name, address and date of birth, but without health related information. Cancer history is added to a family by a record linkage procedure combining members of the family trees with cancer histories in the Munich CancerRegistry (MCR). A specific data protection concept guarantees anonymity for families and their cancer histories. Prevalence of familial CRC risk in upper Bavaria and the posterior probability of a family to carry CRC risk can be inferred from the anonymous data. Strength of simple familial CRC risk detection tools can also be assessed. Results: Per year, 141 clinical departments and 24 oncological practices report about 1300 incident CRC cases (below 70 years) to the MTR. Recruitment of patients started in September 2012. During the first year, we recruited 456 patients in 27 clinical departments and 6 oncological practices and contacted 1,600 relatives. Participation of relatives is reluctant in spite different information sources (leaflet, call center, internet) on the study purpose are provided. Record linkage creates an anonymous collection of CRC family histories. 37 families with a CRC patient below the age of 50 are recorded. They are recruited into a psycho-oncological substudy. First risk estimates will be available end of 2013. Conclusions: For the first time, the study offers population based data on familial CRC risk in a German population of 4.6 mio. people. The results strengthen the concept of familial CRC risk for the development of appropriate preventive screening strategies.
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Tadrous, Ragy, Deirdre O’Rourke, Julie Broderick, and David Mockler. "509 Health-Related Quality of Life in Narcolepsy: A Systematic Review and Meta-Analysis." Sleep 44, Supplement_2 (May 1, 2021): A200—A201. http://dx.doi.org/10.1093/sleep/zsab072.508.
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Abstract Introduction Narcolepsy is a neurological condition that has been associated with considerable detriment to daily life including impaired quality of life, occupational and academic difficulties and adversely affected social and personal relationships. To date, there has been no systematic analysis of the literature regarding health-related quality of life (HRQoL) in Narcolepsy. This systematic review aimed to examine the impact of narcolepsy on HRQoL, measured through standardised HRQoL questionnaires such as the Short Form 36 (SF36). Methods Medline, Embase, Cinahl and Web of Science were searched for studies which investigated HRQoL in adults with narcolepsy. Studies were reviewed independently by two reviewers, and a random-effects meta-analysis was performed. The methodological quality of the included studies was assessed using a modified version of the Joanna Briggs Institute Checklist for Analytical Cross Sectional Studies tool. The impact of study variables and characteristics on HRQoL was assessed using Spearman’s Correlation analyses with adjusted r2 values. Results A total of 30 studies were eligible for inclusion in the review. Additionally, meta-analyses were conducted for the SF36 and the EQ5D. The SF36 meta-analysis identified that the pooled mean scores for the Physical Component Summary (45.91) were less affected than the Mental Component Summary (42.98). The HRQoL of people with narcolepsy was compared to general population norms (US, UK, France and Norway) and to people with chronic diseases including multiple sclerosis, diabetes, and epilepsy. Conclusion People with narcolepsy report significant impairments in HRQoL when compared to the general population and other chronic health conditions including epilepsy, multiple sclerosis, diabetes and hypertension, especially concerning their mental wellbeing. Further research is warranted to identify the longitudinal effects of narcolepsy on HRQoL and to develop a narcolepsy-specific HRQoL tool. Support (if any) This review was completed as part of Mr Ragy Tadrous’ Master of Science (MSc) degree in Trinity College Dublin. This degree was co-sponsored by the Physiotherapy Department in St. James’s Hospital, Dublin.
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Tadrous, Ragy, Julie Broderick, Niamh Murphy, Lisa Slattery, Gillian Quinn, and Deirdre O’Rourke. "510 A Profile of Physical Performance Variables in an Out-Patient Adult Population with Narcolepsy." Sleep 44, Supplement_2 (May 1, 2021): A201. http://dx.doi.org/10.1093/sleep/zsab072.509.
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Abstract Introduction Narcolepsy can significantly impact the physical and mental wellbeing of people with narcolepsy, and has been associated with significant reductions in quality of life and physical performance. People with narcolepsy demonstrate many barriers to being physically fit and active, such as sleepiness and social isolation. Despite physical functioning and vitality being the most affected domains of health-related quality of life in this cohort, little is known about how physical performance variables are affected in people with narcolepsy. Methods This cross-sectional study profiled the physical performance of adults with narcolepsy attending the Narcolepsy Centre located in St. James’s Hospital. Participants underwent a physical performance test battery that investigated cardiopulmonary fitness, physical activity, muscle strength and endurance. Furthermore, health-related quality of life (HRQoL), symptom severity and sedentary behaviour was ascertained through self-report questionnaires. Results A total of 23 participants were recruited in this study. The majority of participants were female (n=13, 56.52%) and the mean age was 31.53 (± 13.17) years. Physical performance was generally found to be lower than age-and-gender matched normative values for cardiopulmonary fitness, physical activity and muscle strength and endurance. Participants’ completed 42.20 ± 21.41 minutes of moderate-vigorous physical activity daily as measured by actigraphy. Considerable sedentary behaviour was objectively measured in this sample (10.21 hours). Symptom severity was high as measured by the Epworth Sleepiness Scale and the Narcolepsy Severity Scale, and participants reported reduced quality of life when compared to general population norms (US, UK, France and Norway). Conclusion Markedly reduced physical performance was identified in this sample of people with narcolepsy, irrespective of participant age, gender and BMI. Future research should explore the role of exercise in improving the physical fitness in people with narcolepsy, and the influence of exercise on HRQoL and symptom severity in this cohort. Support (if any) This study was completed as part of Mr Ragy Tadrous’ Master of Science (MSc) degree in Trinity College Dublin. This degree was co-sponsored by the Physiotherapy Department in St. James’s Hospital, Dublin.
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Borate, Uma, Amy S. Ruppert, Fei Yang, Dan Jones, Sean Caruthers, Weiqiang Zhao, Jo-Anne Vergilio, et al. "Newly Diagnosed AML Patient Samples Demonstrate High Degree of Concordance in Identification of Pathogenic Mutations By Next Generation Sequencing (NGS) Performed at Enrolling Institutions Compared to Central Laboratory Results in the Beat AML Master Trial." Blood 134, Supplement_1 (November 13, 2019): 2145. http://dx.doi.org/10.1182/blood-2019-131253.
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Background: NGS of myeloid mutations is an integral part of AML clinical decision-making. There is currently no information regarding concordance between NGS panels in AML using samples from the same patient across various platforms in different diagnostic laboratories. To study this important question, we analyzed NGS of myeloid mutations in diagnostic samples from The Beat AML Master Trial (BAMT) for newly diagnosed older AML patients, and compared variant calls made between institutional laboratories enrolling the study subject with those made by Foundation Medicine (FM), the central laboratory used for treatment assignment in this precision medicine trial. Methods: We identified newly diagnosed AML patient samples (peripheral blood (PB) and/or bone marrow (BM)) from 2 lead institutions in the BAMT(Ohio State, OSU and Oregon Health and Sciences University, OHSU) that were analyzed by both the institutional and by FM from Nov 15, 2016 to Apr 15, 2019. Samples sent to both laboratories >3 days apart were excluded. Samples were analyzed at the institutional laboratories using their respective NGS mutational panels and by FM using the FoundationOne®Heme(FMH) NGS panel which utilizes capture based sequencing. The OSU NGS assay utilizes sequencing on Illumina MiSeq. The OHSU NGS assay employs semiconductor-based sequencing (Ion Torrent PGM platform). The variant allele frequency (VAF) sensitivity for detection for all 3 laboratories range from 1-2%. We evaluated the ability to identify mutations in 8 genes : FLT3, IDH1/ 2, NPM1, TET2, DNMT3A, WT1 and TP53 used in treatment assignment in theBAMT. A detection cutoff of 2% was used to define the presence or absence of a mutation. Overall, agreement was defined as the number of times the local and central laboratories made the same call divided by the total number of patients. Sensitivity was defined as the number of present calls made locally divided by the number of present calls made centrally, and specificity as the number of absent calls made locally divided by the number of absent calls made centrally. The overall kappa statistic, controlling for institution, provided another measure of agreement between local and central calls, where a value of 1 indicates perfect agreement. Results: 194 patient samples were identified using methods above and analyzed locally at the screening institution (125 at OSU, 69 at OHSU) and centrally at FM. Type of tissue analyzed for variants between local site and FM were 59 PB, 129 BM, and 6 with BM/PB mismatch. Overall agreement in presence/absence calls between local and central results for each of the 8 genes was over 95% (Table 1). There was perfect agreement for NPM1. The sensitivity was above 94% for all genes except TP53 (88.6%) and WT1 (63.6%). Failure to detect a mutation locally was primarily due to reporting of all TP53 variants, including variants of unknown significance (VUS) (5) by FM as agreed upon in the study protocol, detection at low levels below local site sensitivity cutoff (1), detection of variants in a portion of gene not covered at the local site(1)and possible artifact (1). For the WT1 gene, discordance in 5 samples included VUS (3) reported by FM ,a variant detected in a portion of the gene not covered at the local site(1).and difference in leukemic tissue analyzed with mutation not detected by the central laboratory on a PB sample, and present at the institutional lab on a BM sample; affecting the overall agreement and specificity but not sensitivity. Specificity was at least 98% for each of the 8 genes. Finally, most discrepancies in reported mutations in FLT3 (n=2), IDH1 (n=1), IDH2 (n=2), DNMT3A (n=4) and TET2 (n=5) were due to reporting of VUS in one laboratory and not by another. Conclusion: Detection of pathogenic myeloid mutations using orthogonal assays showed a high degree of concordance for genes used in therapeutic assignment on the BAMT.The small number of discordant results, in TP53 and WT1, were attributed to the reporting of VUS. This study illustrates the importance of quality control and standardization as NGS continues to be widely utilized in AML for clinical decision making, with a variety of platforms across multiple laboratories. Our next steps involve evaluating the differences in VAFs reported between local and central laboratories when a given mutation is identified, as well as the potential reasons for observed differences and clinical implications of known pathogenic mutations vs putative VUS. Disclosures Borate: Daiichi Sankyo: Consultancy; AbbVie: Consultancy; Novartis: Consultancy; Takeda: Consultancy; Pfizer: Consultancy. Vergilio:Foundation Medicine: Employment; Roche Holding AG: Equity Ownership. Stein:Novartis: Membership on an entity's Board of Directors or advisory committees; Celgene Corporation: Membership on an entity's Board of Directors or advisory committees; Daiichi Sankyo, Inc.: Membership on an entity's Board of Directors or advisory committees; Agios: Consultancy, Membership on an entity's Board of Directors or advisory committees; Astellas Pharma US, Inc: Membership on an entity's Board of Directors or advisory committees; Bioline: Membership on an entity's Board of Directors or advisory committees; Genentech: Membership on an entity's Board of Directors or advisory committees; PTC Therapeutics: Membership on an entity's Board of Directors or advisory committees; Syros: Membership on an entity's Board of Directors or advisory committees. Patel:France Foundation: Honoraria; Dava Oncology: Honoraria; Celgene: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau. Baer:Astellas: Research Funding; Abbvie: Research Funding; AI Therapeutics: Research Funding; Forma: Research Funding; Incyte: Research Funding; Kite: Research Funding; Takeda: Research Funding. Stock:Daiichi: Membership on an entity's Board of Directors or advisory committees; Astellas: Membership on an entity's Board of Directors or advisory committees; Agios: Membership on an entity's Board of Directors or advisory committees; Research to Practice: Honoraria; UpToDate: Honoraria; Kite, a Gilead Company: Membership on an entity's Board of Directors or advisory committees; Pfizer: Membership on an entity's Board of Directors or advisory committees. Schiller:Amgen: Other, Research Funding; Astellas: Research Funding; Biomed Valley Discoveries: Research Funding; Bristol Myer Squibb: Research Funding; Celgene: Research Funding, Speakers Bureau; Constellation Pharmaceutical: Research Funding; Daiichi Sankyo: Research Funding; Eli Lilly and Company: Research Funding; FujiFilm: Research Funding; Genzyme: Research Funding; Gilead: Research Funding; Incyte: Research Funding; J&J: Research Funding; Jazz Pharmaceuticals: Honoraria, Research Funding; Karyopharm: Research Funding; Novartis: Research Funding; Onconova: Research Funding; Pfizer Pharmaceuticals: Equity Ownership, Research Funding; Sangamo Therapeutics: Research Funding; Agios: Research Funding, Speakers Bureau. Blum:AmerisourceBergen: Consultancy; Boehringer Ingelheim: Research Funding; Celgene: Research Funding; Astellas,: Research Funding; Xencor: Research Funding; Forma: Research Funding. Kovacsovics:Pfizer: Research Funding; Jazz: Consultancy; Novartis: Research Funding; Abbvie: Research Funding; Amgen: Consultancy, Research Funding. Foran:Agios: Honoraria, Research Funding. Druker:Pfizer: Research Funding; OHSU (licensing fees): Patents & Royalties: #2573, Constructs and cell lines harboring various mutations in TNK2 and PTPN11, licensing fees ; Cepheid: Consultancy, Honoraria; Aileron Therapeutics: #2573, Constructs and cell lines harboring various mutations in TNK2 and PTPN11, licensing fees , Membership on an entity's Board of Directors or advisory committees; ALLCRON: Membership on an entity's Board of Directors or advisory committees; Amgen: Equity Ownership, Membership on an entity's Board of Directors or advisory committees; Aptose Biosciences: Consultancy, Equity Ownership, Membership on an entity's Board of Directors or advisory committees; Beta Cat: Membership on an entity's Board of Directors or advisory committees, Other: Stock options; GRAIL: Equity Ownership, Other: former member of Scientific Advisory Board; Patient True Talk: Consultancy; The RUNX1 Research Program: Membership on an entity's Board of Directors or advisory committees; Vivid Biosciences: Membership on an entity's Board of Directors or advisory committees, Other: Stock options; Beat AML LLC: Other: Service on joint steering committee; CureOne: Membership on an entity's Board of Directors or advisory committees; Celgene: Consultancy; Gilead Sciences: Other: former member of Scientific Advisory Board; ICON: Other: Scientific Founder of Molecular MD, which was acquired by ICON in Feb. 2019; Monojul: Other: former consultant; Novartis: Other: PI or co-investigator on clinical trial(s) funded via contract with OHSU., Patents & Royalties: Patent 6958335, Treatment of Gastrointestinal Stromal Tumors, exclusively licensed to Novartis, Research Funding; Bristol-Myers Squibb: Other: PI or co-investigator on clinical trial(s) funded via contract with OHSU., Research Funding; Pfizer: Other: PI or co-investigator on clinical trial(s) funded via contract with OHSU., Research Funding; Merck & Co: Patents & Royalties: Dana-Farber Cancer Institute license #2063, Monoclonal antiphosphotyrosine antibody 4G10, exclusive commercial license to Merck & Co; Dana-Farber Cancer Institute (antibody royalty): Patents & Royalties: #2524, antibody royalty; Burroughs Wellcome Fund: Membership on an entity's Board of Directors or advisory committees; Blueprint Medicines: Consultancy, Equity Ownership, Membership on an entity's Board of Directors or advisory committees; Bristol-Myers Squibb: Patents & Royalties, Research Funding. Byrd:Gilead: Other: Travel Expenses, Research Funding, Speakers Bureau; Genentech: Research Funding; Acerta: Research Funding; TG Therapeutics: Other: Travel Expenses, Research Funding, Speakers Bureau; Novartis: Other: Travel Expenses, Speakers Bureau; Pharmacyclics LLC, an AbbVie Company: Other: Travel Expenses, Research Funding, Speakers Bureau; Janssen: Consultancy, Other: Travel Expenses, Research Funding, Speakers Bureau; BeiGene: Research Funding; Ohio State University: Patents & Royalties: OSU-2S. Levine:C4 Therapeutics: Membership on an entity's Board of Directors or advisory committees; Isoplexis: Membership on an entity's Board of Directors or advisory committees; Celgene: Consultancy, Research Funding; Roche: Consultancy, Research Funding; Loxo: Membership on an entity's Board of Directors or advisory committees; Qiagen: Membership on an entity's Board of Directors or advisory committees; Amgen: Honoraria; Prelude Therapeutics: Research Funding; Novartis: Consultancy; Gilead: Consultancy; Lilly: Honoraria; Imago Biosciences: Membership on an entity's Board of Directors or advisory committees. Mims:Jazz Pharmaceuticals: Membership on an entity's Board of Directors or advisory committees; Astellas Pharmaceuticals: Membership on an entity's Board of Directors or advisory committees; PTC Therapeutics: Membership on an entity's Board of Directors or advisory committees; Agios Pharmaceuticals: Membership on an entity's Board of Directors or advisory committees; Abbvie: Membership on an entity's Board of Directors or advisory committees.
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Wardani, Yulia. "The Competencies, Roles and Scope of Practice of Advanced Psychiatric Nursing in Indonesia." Nurse Media Journal of Nursing 3, no. 2 (August 19, 2013): 631–48. http://dx.doi.org/10.14710/nmjn.v3i2.6004.
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The graduate advanced psychiatric nursing (psychiatric nursing specialist) from master degree in Indonesia are about 70 nurses, 67 nurses were graduated from University of Indonesia. They are working at mental health services and educational setting around Indonesia and yet seem not ready to perform some specific advanced competencies in clinical area. The mastery on mental health assessment, neurochemical perspectives, medical management and psychotherapy have not yet performed by the psychiatric nurse specialist in the clinical area or community.To have those competencies and its performances, therefore the curriculum in a psychiatric nursing graduate program must include advanced courses in physiopsychology, psychopathology, advanced psychopharmacology, neurobehavioral science, advanced mental health assessment, and advanced treatment interventions such as psychotherapy and prescription and management of psychotropic medications as their core and major courses in the curriculum. Those courses should be performed in their clinical practice courses or other related learning experiences. When those qualifications are met, then they are competent to be called advanced psychiatric nurse.As advanced practice registered nurses, the advanced psychiatric nurses should be able to demonstrate their direct expertise and roles in advanced mental health assessment, diagnostic evaluation, psychopharmacology management, psychotherapy with individuals, group and families, case management, millieu management, liason and counselling from prevention, promotion until psychiatric rehabilitation. Meanwhile the skill such as psycho-education, teaching, unit management, research and staff development can be added as their indirect roles.
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McCracken, Karen W., Peter Mayinger, and Cynthia Morris. "3446 The OHSU Physician-Scientist Experience: Integrating intensive translational research training for medical students into a competency-based educational framework." Journal of Clinical and Translational Science 3, s1 (March 2019): 74–75. http://dx.doi.org/10.1017/cts.2019.176.
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OBJECTIVES/SPECIFIC AIMS: The aim of this program is to provide early support to motivated medical students interested in a career as a physician-scientist in a framework of competency-based medical education. The CTSA creates an opportunity to provide clinical research education and protected time for research for medical students in clinical and translational research. METHODS/STUDY POPULATION: This physician-scientist experience offers research opportunities in a wide variety of research disciplines, focused on clinical and translational investigations. The program offers both five-month and one-year blocks of protected research time. The five-month option is integrated into the four- year medical curriculum. The one-year option requires enrollment in an established Master of Clinical Research degree. Both options provide research experience under the mentorship of a physician-scientist. The five-month option aligns with UME competencies categorized under the six ACGME Domains of Competence. The one-year option includes coursework in research design, biostatistics, research ethics, data management, scientific communication, and proposal development within the CTSA-based education program. All students in the program attend a bimonthly journal club and seminar series starting in year one and extending through the research experience. This includes discussion of the importance of mentorship, selecting a residency, scientific writing and presentation, and personal narratives of physician-scientists and their pathways to this career. All students will be followed to determine career outcome. RESULTS/ANTICIPATED RESULTS: Between 2015 and 2018, 67 students entered the program 46% selected the year out, and 56% selected the 5-month option. Students selecting this program constitute about 10% of the medical student population overall. We have had 17 graduates of the program to date. 55% of the cohort is women which parallels the OHSU medical student population. Long-term follow-up of at least 10 years will be needed to determine career outcomes. We assess student productivity by traditional measures of submitted abstracts, manuscripts, and presentations as well as longer term outcomes such as career orientation in medicine such as entry into a research-oriented residency and ultimately into an academic medicine or research. DISCUSSION/SIGNIFICANCE OF IMPACT: The OHSU physician-scientist experience successfully matches medical students with a diverse set of research mentors focused on the CTSA. Although institutional structures determine the variety of specific research opportunities, the integration of physician-scientist training into a CTSA-based training program expands the reach of training programs such as the TL1.
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Hutchison, Barbara, Eleanor K. Covan, and Janet C. Bogus. "Presbycusis, Part 1: Can You Hear the Music Of Life?" Care Management Journals 13, no. 3 (September 2012): 148–72. http://dx.doi.org/10.1891/1521-0987.13.3.148.
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We used a novel approach allowing participants in this study to self-monitor their hearing sensitivity to familiar sounds in the environment. The objective of this approach was to establish whether participants in the 80–89 and 90–99 age groups would recognize the degree of their hearing impairment. It was our hope that participants would value audiology treatment and that it would improve their quality of life over a short period. The pilot study took place in a clinical environment where participants answered survey questions before and after audiology treatment, which pertained to their hearing impairment, morale, social support, and life satisfaction. Caregivers were included in the research to rate and record participants’ problem behaviors (e.g., shouting, anger, agitation, repetitive speech dialog, and depression) before, during, and after treatment. This research validates other scientists’ findings that annoying problem behaviors may actually be the result of hearing loss because of a person’s inability to recognize speech. The pilot study shows that participants with mild dementia adapted well to speech and sounds in the natural environment without agitation as well as to management of hearing aids within a 30-day period. The participants with moderate dementia were slower to adapt. All participants with dementia required the cooperation of their caregivers to maintain hygiene of ear canals and hearing aids and insertion. This study suggests that the sooner people receive treatment for hearing loss, the quicker they are to recognize speech and to master hearing aid technology.
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Macdiarmid, Rachel, Rhona Winnington, and Eamon Merrick. "Exploring case based clinical learning in graduate-entry nursing." Pacific Journal of Technology Enhanced Learning 2, no. 1 (December 18, 2019): 29–30. http://dx.doi.org/10.24135/pjtel.v2i1.57.
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The Master of Nursing Science (MNSc) has been developed as a Graduate Entry to Nursing (GEN) programme. It is an accelerated, intensive two-year degree involving the completion of 1100 clinical practice hours to meet New Zealand Nursing Council registration requirements, together with achieving a level of critical thinking that will support excellence in clinical practice. GEN programmes are well known to attract diverse, motivated graduates often with successful careers that want a change of direction (Stacey, Pollock & Crawford, 2016; Pellico, Terrill, White & Rico, 2012).
In 2019 the MNSc was in its first iteration, therefore the three lecturers involved had scope to consider the design and delivery of the learning to best support student understanding and engagement. Together with institutional teaching and learning development mentors we brainstormed different approaches to teaching and learning. There is dearth of evidence regarding the development of clinical reasoning and critical thinking for post-graduate nursing students in Australasia. The aim was to develop teaching approaches that encouraged students to engage with the content and foster the development of critical thinking and clinical reasoning. Meyers and Nulty’s (2009) adoption of Biggs (2003) 3P Model of learning and teaching influenced the development of content across multiple discrete units of study. An evolving case study approach supported with podcasts was developed. The first evolving case study focused on a client with a rural New Zealand address and health status common to his age group and life experience. The podcasts aligned with the weekly development of the case. International content experts participated in topics as varied the management of analgesia, history of consent, and assisted dying and others.
To iteratively explore and understand the effectiveness of this teaching approach the authors concurrently undertook research. Informed by educational design research (EDR) methodology we explore the process of constructing an authentic learning experience for students. Educational design research (EDR) evolved from design-based research and is recognised as being practical and eminently suitable to explore a small teaching and learning project (Jetinikoff, 2015; McKenney & Reeves, 2018). The aims of this research were to 1) explore and describe the process of constructing an authentic learning experience enabled by technology; and 2) understand and reflect on student learning using an evolving case-study with podcasted content. The research team is currently undertaking the reflection, adaption, and evaluation stage of the EDR methodology. The results of this and the theory stage will be resented at SoTEL. In this presentation, the analysis of the teaching teams’ reflections will be explored. Key to our discussion with the audience will be sharing our reflections and in turn seeking their advice to explore how to engage students in technology enhanced delivery in a fast-paced course.
References:
Biggs, J.B. (2003). Teaching for quality learning at university. (2nd ed.). Maidenhead: Open University Press.
Jetnikoff, A. (2015). Design based research methodology for teaching with technology in English. English in Australia, 50(3), 56-60.
McKenney, S., & Reeves, T. (2018). Conducting Educational Design Research (2nd ed.). Routledge: https://ebookcentral.proquest.com/lib
Meyers, N. M., & Nulty, D. D. (2009). How to use (five) curriculum design principles to align authentic learning environments, assessment, students approaches to thinking and learning outcomes. Assessment & Evaluation in Higher Education, 34, (5), 565–577.
Pellico, L.H., Terrill, E., White, P., & Rico, J. (2012). Integrative review of graduate entry programs. Journal of Nursing Education, 51(1), 29-37. http://dx.doi:10.3928/01484834-20111130-01.
Stacey, G. Pollock, K., & Crawford, P. (2016). The rules of the game in graduate entry nursing: A longitudinal study. Nurse Education Today, 36, 184-189. http://dx.doi:10.org/10/1016/j.nedt.2015.09.016
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Ibrahim, Mohamed Elmi, Recep Erçin Sönmez, Ahmed Yusuf Guleid, and Orhan Alimoğlu. "The Prevalence of Diabetes Mellitus Among High School and University Teachers in Mogadishu, Somalia." International Journal of Human and Health Sciences (IJHHS) 4, no. 2 (January 12, 2020): 94. http://dx.doi.org/10.31344/ijhhs.v4i2.182.
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Background: Primary objective of the present study is to describe the main risk factorsof diabetes mellitus (DM) and to determine its prevelance among high school and university teachers in Mogadishu, Somalia.Materials and Methods: Current study is designated as a research survey in an attempt to collect data from members of a certain population in order to determine the actual status of diabetes mellitus (DM) in respect to multiple variables (risk factors, awareness, prevelance). The study populationhad beenselected fromhigh school and university teachers who reside and work in Mogadishu, Somalia.Results:A total of 222 (M/F (135/87)) respondents were included in the study of whom mostly were university teachers (n=128 (57.7%)), and less were high school teachers (n=94 (42.3%)). Majority of the population had been consisted of those graduated with degree (n=100 (45%)), and less were the ones with diploma (n=51 (23%)), secondary certificate (n=40 (18%)), master degree (n=29 (13.1%)) and PhD (n=2 (0.9%)) in decreasing frequency. Most of respondents were less than 60 years of age (n=196 (89.2%)) that the majority were within 30-40 years interval (n=74 (33.3%)). Prevelance of diabetes mellitus (DM) was found as 36.5% (n=81). Though, only 15 (18.5%) patients had prior knowledge of which type of DM (1 or 2) they had.Conclusion:Interactional educational programs should be conducted both in public environment as well as in schools to improve knowledge and awareness of the community about clinical outcomes of diabetes mellitus (DM) on common health. Establishment of new screening programs will aid in prevention of adverse effects related to diabetes mellitus (DM).International Journal of Human and Health Sciences Vol. 04 No. 02 April’20 Page : 94-97
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Collier, A., S. A. Bartels, and D. Messenger. "MP21: Global emergency medicine fellowship: establishing a global EM training program at Queen’s University." CJEM 20, S1 (May 2018): S47—S48. http://dx.doi.org/10.1017/cem.2018.175.
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Introduction: Global Emergency Medicine (Global EM) is growing rapidly as an academic niche in Canada. An increasing number of Canadian emergency physicians work internationally as part of their practice, and trainees consistently seek out international projects and electives. For the most part however, residents have had to create their own training opportunities as formal Global EM fellowship training has been lacking in Canada. To address this identified need, Queens University established a Global EM fellowship, the first of its kind in the country. Methods: The fellowship is designed to provide the skills necessary for an academic career in Global Emergency Medicine. Curriculum and objectives are modeled on similar well-established fellowships in the United States. Areas of expertise include emergency medicine systems development, humanitarian medicine, disaster response, public health, tropical medicine, research, administration and education. Fellows have the opportunity to tailor their training according to their specific interests within these domains. Importantly, the fellowship provides direct mentorship from academic global EM and public health physicians, and networking opportunities within the global health sphere. Results: The two-year fellowship curriculum is divided between: 1) coursework to complete a Master of Public Health (MPH) Degree 2) fieldwork 3) relevant international emergency medicine training courses and 4) clinical work in the emergency departments at the Kingston Health Sciences Center. The Queens Global EM fellowship admitted its first fellow in August 2017. To date, the inaugural fellow has completed the MissionCraft Leadership in Disaster Relief course as well as a Humanitarian U Disaster and Response course, in addition to submitting a research grant as a co-principal investigator, starting coursework for an MPH degree and giving several invited lectures on humanitarian medicine. The fellow also travelled to Lebanon to support research in collaboration with aid organizations responding to the Syrian crisis. Upcoming fieldwork involves teaching at a newly established emergency medicine residency program in Haiti as well as a humanitarian crisis deployment. Conclusion: In response to a lack of formal international emergency medicine training opportunities in Canada, Queens University has established a Global Emergency Medicine fellowship. The fellowship aims to provide protected time, access to field opportunities and dedicated mentorship to develop the skills necessary to succeed as an academic Global EM physician. We believe it provides a unique opportunity to significantly expand fellows experiences in global health fieldwork, education and research while continuing to practice in a Canadian tertiary emergency department.
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Volmer, Daisy, Kristiina Sepp, An Raal, and Jeffrey Atkinson. "Pharmacy Practice and Education in Estonia." Pharmacy 7, no. 3 (July 10, 2019): 87. http://dx.doi.org/10.3390/pharmacy7030087.
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The Pharmacy Education in Europe (PHARMINE) project studied pharmacy practice and education in the European Union (EU) member states. The work was carried out using an electronic survey forwarded to selected pharmacy representatives at community and hospital pharmacies, in the pharmacy industry and at drug authorities. The surveys of the individual member states are now being published as reference documents for students and staff interested in research on pharmacy education in the EU, and in mobility. This paper presents the results of the PHARMINE project on pharmacy practice and education in Estonia. In this paper, we examine the harmonisation of practice and education in Estonia with EU norms. Community pharmacies in Estonia provide traditional and extended services, of which influenza vaccination, the evaluation of the risk of diabetes, and medication use review have been introduced recently. Pharmacists (in Estonian proviisor) study at the University of Tartu for five years and graduate with a Master of Pharmacy (MSc Pharm) degree. A pharmacist can be the owner of a pharmacy, or work as a pharmacy manager or chief pharmacist in either a community or a hospital pharmacy. Assistant pharmacists (in Estonian farmatseut) study at the Tallinn Health Care College for 3 years; after graduation, they are mainly employed in community pharmacies. The University of Tartu is the only university in Estonia providing higher education in pharmacy at university level. The pharmacy curriculum is an integrated (bachelor followed by master), pharmaceutical product-oriented study programme. It was last updated in 2019. On that occasion, several changes were made such as the introduction of competency-based modules; novel methods in education and training based on the constructive alignment and the restructuring of the six-month traineeship. Several new courses focus on the concepts of clinical pharmacy and on patient-centred communication. In the current pharmacy curriculum, there is a balance between chemical and medical subjects. The traineeship is provided for six months at a community and/or hospital pharmacy in the 5th year. Currently, the pharmacy curriculum at the University of Tartu does not offer specialization in subjects such as hospital or industrial pharmacy.
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Vu, Bao Gia, Mark A. Stamnes, Yu Li, P. David Rogers, and W. Scott Moye-Rowley. "The Candida glabrata Upc2A transcription factor is a global regulator of antifungal drug resistance pathways." PLOS Genetics 17, no. 9 (September 30, 2021): e1009582. http://dx.doi.org/10.1371/journal.pgen.1009582.
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The most commonly used antifungal drugs are the azole compounds, which interfere with biosynthesis of the fungal-specific sterol: ergosterol. The pathogenic yeast Candida glabrata commonly acquires resistance to azole drugs like fluconazole via mutations in a gene encoding a transcription factor called PDR1. These PDR1 mutations lead to overproduction of drug transporter proteins like the ATP-binding cassette transporter Cdr1. In other Candida species, mutant forms of a transcription factor called Upc2 are associated with azole resistance, owing to the important role of this protein in control of expression of genes encoding enzymes involved in the ergosterol biosynthetic pathway. Recently, the C. glabrata Upc2A factor was demonstrated to be required for normal azole resistance, even in the presence of a hyperactive mutant form of PDR1. Using genome-scale approaches, we define the network of genes bound and regulated by Upc2A. By analogy to a previously described hyperactive UPC2 mutation found in Saccharomyces cerevisiae, we generated a similar form of Upc2A in C. glabrata called G898D Upc2A. Analysis of Upc2A genomic binding sites demonstrated that wild-type Upc2A binding to target genes was strongly induced by fluconazole while G898D Upc2A bound similarly, irrespective of drug treatment. Transcriptomic analyses revealed that, in addition to the well-described ERG genes, a large group of genes encoding components of the translational apparatus along with membrane proteins were responsive to Upc2A. These Upc2A-regulated membrane protein-encoding genes are often targets of the Pdr1 transcription factor, demonstrating the high degree of overlap between these two regulatory networks. Finally, we provide evidence that Upc2A impacts the Pdr1-Cdr1 system and also modulates resistance to caspofungin. These studies provide a new perspective of Upc2A as a master regulator of lipid and membrane protein biosynthesis.
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Li, Wei Han, Maryam Hadizadeh, Ashril Yusof, and Mohamed Nashrudin Naharudin. "Analysis of Research Trends on Elbow Pain in Overhead Sports: A Bibliometric Study Based on Web of Science Database and VOSviewer." Healthcare 10, no. 11 (November 9, 2022): 2242. http://dx.doi.org/10.3390/healthcare10112242.
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The publications on elbow pain (EP) in overhead sports are increasing. The results of previous studies mostly focus on the influence of EP in the ball game and throwing sports. Thus, a bibliometric analysis of these publications may show the direction of hot topics and future research trends. The purpose of this study is to identify the research trends on EP in overhead sports. For the methods, the first step is to use the main keywords of ‘Elbow pain’ and ‘Overhead sport’ merging auxiliary vocabulary to reach the relevant global publications between 1970 and 2022 in the Web of Science (WoS) database. The literature data set is imported into EndNote literature manager software to remove duplication. Secondly, the duplication-reduced articles are imported to an Excel sheet according to the inclusion and exclusion criteria of this study. In the third step, VOSviewer software is applied as the main analysis tool in extracting data for analysis from the articles. Then, the main research results for three aspects are obtained by VOSviewer software which extracted and analyzed the parameters of author name, article title, publication journal, keywords, organization, publication country/region, and the sum of times cited from 455 qualified papers. The study found that the United States of America made the most outstanding contribution to this theme study. The research on EP in overhead sports in China requires more attention from scholars. EP in swimming is a new research direction worthy of attention. In conclusion, the research results prove the growth trend of EP in overhead sports. The EP problem not only exists in the ball game and throwing sports but also swimming. Sport commercialization and the involvement of related professional sports organizations determine the degree of EP’s attention in a specific sport and the development of solutions. The development of a region or country also affects the depth and scope of EP study. Clinical research development and in-depth exploration are one of the bases to solve EP problems. Non-clinical action is beneficial to EP patients, but it still needs to be explored and studied.
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Nazari, Elham, Mehran Aghemiri, Seyed Mohammad Tabatabaei, Sayyed Mostafa Mostafavi, Shokoufeh Aalaei, Saeed Eslami HasanAbady, and Hamed Tabesh. "Thesis Conducted by Student in Medical Informatics Field Based on Health Informatics Competencies Framework: A Study in Iran." Frontiers in Health Informatics 9, no. 1 (September 2, 2020): 42. http://dx.doi.org/10.30699/fhi.v9i1.230.
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Introduction: One of the challenges of multidisciplinary disciplines such as Medical Informatics, health information technology, etc., especially for those who have just started research in this field, is the lack of familiarity with research fields in this field. Medical Informatics has various research fields related to the use of technology in the field of health care with the aim of reducing costs, improving the quality of health care and reducing possible medical errors. Iran is a country where medical informatics is a fledgling field and few universities in This field is accepted by students. Due to the specializations and clinical facilities concentrated in each university, research is being done differently and with variety. At the same time, some important fields related to the field may be missed. Therefore, in this study, in order to identify the most researched fields in this field and the neglected fields of research, the dissertations done in the field of medical informatics in Iranian universities were reviewed based on the health informatics framework.Materials and methods: Defended dissertations available to master and doctoral students in medical informatics in the years 2001 to 2018 in the universities of Tehran, Iran, Tarbiat Modares, Shahid Beheshti, Shiraz, Tabriz and Mashhad were collected in this study. Three medical informatics graduates from different universities assigned dissertation titles to a competency and an area of skill based on the Health Informatics Competencies Framework. The second stage of the study was performed by two other experts (different from the previous three experts). At this stage, the opinions of three experts on thesis were compared. Each dissertation title was assigned to a specific competency and a specific area of skill by the majority opinion method. Results: The results showed that most of the master's and doctoral dissertations in medical informatics were in the field of information science and methods, in which area of skill (data analysis and visualization) and decision support systems and informatics for participatory health were more than others. PhD students and the area of skill (decision support system) and (Architecture of health IS) are more popular with postgraduate students, while PhD students at the University of Mashhad, Tehran and Shahid Beheshti in the field of methods and basic principles of activities More than other areas, information and communication technology, biomedical science and health were not considered. Shahid Beheshti University had the most activity in the skill (Realization of benefits from IS) in the master's degree and in the degree PhD in skill (Application Mathematical concepts) has the most activity, in total, the most Competencies in which dissertations have been done in the country Competency (information science and core principles and method s) have been. In the universities of Iran, Tehran and Mashhad, the frequency of dissertations in competency (core principles and methods) and in other universities in competency (information science) has been higher. Most research in the doctoral program in 2017 was related to the University of Mashhad. Most of the research in master's degree in 2014 was related to Iran University. Most of the research in the doctoral program in 2017 was related to Mashhad University.Conclusion: The results of this research can help field researchers in conducting new research in the field and can help in useful, scientific and effective design of research projects of researchers, university professors, educational planners and health care service providers. Also, due to the interdisciplinary nature of medical informatics, the use of professors in various fields and specialties in Iranian universities can be effective in defining topics for research for theses.
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Coradi, Cristiane Olinda, Jussara Dos Santos Cardoso, Ronara Camila de Souza Groia, Karina Cristina Lima Silva, Maria das Graças Braga Ceccato, and Marina Guimarães Lima. "Compreensão da prescrição de medicamentos em uma unidade básica de saúde: autorrelato do usuário e aferição pelo pesquisador." Scientia Medica 26, no. 4 (November 24, 2016): 24934. http://dx.doi.org/10.15448/1980-6108.2016.4.24934.
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Aims: To evaluate the understanding of drug prescriptions by patients, comparing the user self-report with the researcher assessment.Methods: A cross-sectional study was conducted from November 2013 to February 2014 at a Basic Health Unit in the city of Belo Horizonte, Minas Gerais, Brazil. Users 18 years of age or older who sought medicines in the unit's pharmacy, for themselves or for minors under their care, were interviewed. The selection of the sample was non-probabilistic, for convenience. During the interview, the users informed if they had understood the following data of the prescriptions: drug name, dose and frequency of administration. Participants then repeated the data for researchers, being allowed to check the prescriptions at the same time. After the interviews, the answers to the questions were interpreted by the researchers, who evaluated the agreement between the information provided by the users and the actual instructions of the recipes, using the Kappa test.Results: Data were collected from 69 users of the unit's pharmacy (corresponding to 69 delivered prescriptions). Fifty-nine (85.5%) users reported having understood all the prescriptions data (self-report), while according to the measurement of the researchers, 23 (33.3%) were the respondents who simultaneously understood all data, relating to the name of the drug, number of daily doses and schedule. Kappa test indicated a degree of agreement between self-report and measurement of researchers of 0.138 (slight) considering all items of the prescription, and specifically on the number of doses the agreement was -0.055 (poor).Conclusions: Self-reported rate of patient's understanding of drug prescriptions was higher than the assessed by the researchers. This result suggests that self-report of patients with respect to the understanding of prescriptions has limitations and should be interpreted with caution both in research and in clinical practice. It is recommended to enhance the means of providing information to patients, in order to contribute to the proper understanding of drug prescriptions.
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Patton, Scott, Elaine Basaca, and Jennifer S. Brown. "2557 Improving ClinicalTrials.gov compliance: A coordinated effort for success." Journal of Clinical and Translational Science 2, S1 (June 2018): 83. http://dx.doi.org/10.1017/cts.2018.288.
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OBJECTIVES/SPECIFIC AIMS: ClinicalTrials.gov (CTgov) compliance has received much international attention as a significant regulatory, scientific, and ethical responsibility. Compliance rates for both industry and academia are held up for scrutiny by transparency advocates, but solutions for achieving compliance in academia have proven to be—because of its focus on innovation and multiple disciplines—significantly more complex than those employed by industry. Added challenges for academic medical centers (AMCs) are both increased researcher responsibilities under the new NIH Policy on Clinical Trial Dissemination and system-wide changes to requirements for “clinical trial only” Funding Opportunity Announcements. At Stanford University, a multifaceted approach toward improving CTgov outreach, education, and reporting led to a dramatic turnaround in compliance over 17-month period. METHODS/STUDY POPULATION: Stanford University School of Medicine’s Senior Associate Dean for Research and PI of Stanford’s CTSA applied a 3-part strategy to address unacceptable rates of results reporting. The strategy included (1) regular compliance reports to department chairs, (2) establishment of a central office, Clinical Research Quality (CRQ), to provide consistent training and support, and (3) interdepartmental cooperation across the school and university. Compliance reports, identifying all studies late for results reporting were sent monthly to all department chairs, with heightened focus on departments that conduct the most clinical trials. Senior leadership described the process in executive meetings and set improvement goals. Reports included multiple data points to help departments mobilize resources and identify trends; half-way through the period, soon-to-be late study records were included. CRQ hired 2 fulltime employees tasked with all aspects of managing the CTgov process and designed a portfolio of activities including: (1) a master list of all Stanford studies in the CTgov system; (2) a process for generating and distributing monthly reports; (3) an education program; and (4) support services, including an administrator working group. RESULTS/ANTICIPATED RESULTS: Since December 2015, Stanford has had the second-highest compliance rate improvement out of the 20 schools of medicine that receive the most NIH funding (+ 62%). DISCUSSION/SIGNIFICANCE OF IMPACT: Managing ClinicalTrials.gov compliance requires a high degree of technical knowledge of regulations, NIH policy, and the CTgov system. But without an equally high degree of engagement from senior leadership, results would not have been achieved. Central resources are critical to set policy and establish consistent processes, but without regular and repeated interactions between faculty, a multitude of administrators and staff, more central resources would have been required. By working simultaneously “down from the top” and “up from the bottom,” communication and education expanded rapidly, ineffective efforts were quickly transformed, and what began as an irritating and cumbersome problem became an occasion for collaboration and celebration of increased transparency.
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Iordanishvili, Andrey K. "The Patriarch of maxillofacial traumatology (on the 100th anniversary of Professor V.A. Malyshev, Colonel of Medical Service)." Russian Journal of Dentistry 26, no. 4 (September 29, 2022): 355–61. http://dx.doi.org/10.17816/1728-2802-2022-26-4-355-361.
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The prominent place in the cohort of famous Russian dentists of XX century belongs to the participant of Great Patriotic War 19411945, Doctor of Medicine, Professor, colonel of medical service Vasily Alekseevich Malyshev (19222006), whose 100-year anniversary is celebrated by Russian stomatological community in 2022.
AIM: To present scientific, clinical, pedagogical and social activity of prominent maxillofacial surgeon Doctor of Medicine, Professor, colonel of medical service V.A. Malyshev, as well as his merits before the Motherland.
To present the role of V.A. Malyshev in formation and development of the military stomatology, maxillofacial surgery and traumatology in Russia on the basis of analysis of the national literature, life and professional activity as well as scientific labors of the doctor of medical sciences, professor, colonel of the medical service.
Scientific works of V.A. Malyshev are mainly devoted to the research of issues of clinic, diagnostics, treatment of fractures of the lower jaw and prevention of traumatism. Having become the master of maxillofacial traumatology, he has significantly improved the diagnostics of maxillofacial injuries and introduced in everyday clinical practice a great number of original methods and effective ways of treatment of the indicated pathology. His scientific and practical developments and suggestions regarding the treatment of patients with maxillofacial region injuries have been widely spread in our country, implemented in practice of many medical preventive institutions and included in many textbooks, manuals and teaching aids used in Russian higher educational institutions. His method of treatment of chronic fractures of mandibular articular process by means of its replantation with following osteosynthesis, which was developed in our country and abroad, gained recognition not only in our country but also abroad.
V.A. Malyshev was one of the oldest military dentists of Russia, a brilliant teacher, an excellent scientist and clinician. His name was well known to the stomatological community of the USSR, and since 1991 in Russia and the former Soviet Union. His work for 50 years was connected with the department of maxillofacial surgery and dentistry of Military Medical Academy named after S.M. Kirov. In 19751988 V.A. Malyshev as an off-duty chief dentist did a lot to improve the organization and provision of dental care to the servicemen and sailors.
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Shaw, Vivien. "Chōng $$ an Ancient Chinese Description of the Vascular System?" Acupuncture in Medicine 32, no. 3 (June 2014): 279–85. http://dx.doi.org/10.1136/acupmed-2013-010496.
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The objectives of this research are, first, to establish if the extraordinary acupuncture meridian known as Chōng $$ Penetrating Vessel or Sea of Blood, is in essence a description of certain macroscopic parts of the underlying vascular system and, second, by extension, to show that it is likely that cadaveric dissection would have been used as a tool to arrive at this understanding. Generally accepted scholarly opinion holds that the ancient Chinese rarely used dissection in order to explore the anatomy of the human body, and that the meridians are therefore invisible metaphysical structures corresponding to lines drawn on the body. However, the seminal text, ‘The Yellow Emperor's Classic of Internal Medicine’, describes using palpation to examine the living and dissection to examine the dead. This implies that the original authors of these texts were observing physical structures visible to the naked eye. Dissection has therefore been used to compare the descriptions of the Chōng meridian in ‘The Yellow Emperor's Classic of Internal Medicine’ with the vascular anatomy of the human body. Fifteen acupuncture points located on various different ordinary meridians but bearing the same name, Chōng $$ were also examined to see if they bore any relationship to the vascular system. The dissections clearly show that the Chōng meridian correlates to certain main blood vessels in the body, in particular the vena cava. Similarly, most Chōng acupuncture points have a strong correspondence with blood vessels, marking terminal arteries on the hands, feet and forehead and anastomoses on the face, body and feet. These findings strongly suggest that the ancient Chinese texts relating to this meridian are likely to have been a ‘description’ of the vascular system. Furthermore, the ancient Chinese apparently had a high degree of anatomical skill in the practice of dissection and acute powers of observation.
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Morgoshia, T. Sh, V. Ya Apchel, and N. A. Syroezhin. "Life and work of Henry Ivanovich Turner (on the 160th anniversary of his birth)." Bulletin of the Russian Military Medical Academy 20, no. 3 (December 15, 2018): 267–71. http://dx.doi.org/10.17816/brmma12391.
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The main life stages of scientific and practical activities of Henry Ivanovich Turner are presented. It is noted that initially G.I. Turner was interested in problems far from orthopedics: acute purulent processes in the right ileal fossa, the cecum and the appendix. In 1892 G.I. Turner defended his doctoral thesis on «the anatomy of the cecum and the vermiform Appendix in relation to the pathology of perityphlitis». In 1894, Turner was admitted to the degree of assistant Professor of clinical surgery, reading two lectures, he was confirmed in this rank. In 1895, held the appointment of Turner Professor of desmurgy and machineryi Military Medical Academy. He revived the teaching of the subject and translated it into «practical ground». Thanks to the energetic work of Turner as an organizer was revived by the Department of desmurgy and machineryi Military Medical Academy and Surgical Museum of the Academy. Under Henry I. the Museum has been enriched with new type of instruments, dressings, and splints, collection of damaged bones, who helped in the study of desmurgy. This collection has survived to the present day and has more than 800 drugs and has no analogues in the country. A lot of effort and energy gave G.I. Turner to help sick children, handicapped, vocational rehabilitation of crippled children. For many years he supervised the work of an orphanage in St. Petersburg (St. Lachtinskaia, 12), which in 1932 was transformed into the research Institute of child disability in the name of G.I. Turner. This Institute became the organizational and methodical centre of childhood disability in the Soviet Union.
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Pastiadis, Konstantinos, Ioannis Vlachos, Evangelia Chatzikyriakou, Yiftach Roth, Samuel Zibman, Abraham Zangen, Dimitris Kugiumtzis, and Vasilios K. Kimiskidis. "Auditory Fine-Tuned Suppressor of TMS-Clicks (TMS-Click AFTS): A Novel, Perceptually Driven/Tuned Approach for the Reduction in AEP Artifacts in TMS-EEG Studies." Applied Sciences 13, no. 2 (January 12, 2023): 1047. http://dx.doi.org/10.3390/app13021047.
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TMS contaminates concurrent EEG recordings with Auditory Evoked Potentials (AEPs), which are caused by the perceived impulsive acoustic noise of the TMS coils. We hereby introduce a novel and perceptually motivated/tuned method for the suppression of auditory evoked EEG artifacts of rTMS under the name of “Auditory Fine-Tuned Suppressor of TMS-Clicks” (TMS-click AFTS). The proposed method is based on the deployment of a psychophysically-matched wide-band noise (WBN) masking stimulus, whose parametric synthesis and presentation are based upon adaptive psychophysical optimization. The masking stimulus is constructed individually for each patient/subject, thus facilitating aspects of precision medicine. A specially designed automation software is used for the realization of an adaptive procedure for optimal parameterization of masking noise level, optimizing both the subject’s comfort and the degree of AEP reduction. The proposed adaptive procedure also takes into account the combined effect of TMS intensity level and can as well account for any possibly available subject’s hearing acuity data. To assess the efficacy of the proposed method in reducing the acoustic effects of TMS, we performed TMS-EEG recordings with a 60 channel TMS-compatible EEG system in a cohort of healthy subjects (n = 10) and patients with epilepsy (n = 10) under four conditions (i.e., resting EEG with and without acoustic mask and sham TMS-EEG with and without acoustic mask at various stimulus intensity levels). The proposed approach shows promising results in terms of efficiency of AEP suppression and subject’s comfort and warrants further investigation in research and clinical settings.
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Arora, Malika, Manpreet Kaur, Parveen Bansal, and Manish Arora. "ATC/DDD Directed Classification of Neural Ayurvedic Medicines." Current Traditional Medicine 5, no. 2 (September 23, 2019): 147–58. http://dx.doi.org/10.2174/2215083804666181002093557.
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Introduction: People have been using herbs for health care since Vedic times. Due to resurgence of ayurveda, utilization and consumption of herbal medicines is tremendously increasing leading to a significant percentage of the pharmaceutical market. The huge commercial benefits of herbal products are capturing the interest of pharmaceutical companies worldwide. Hence the safety and quality of medicinal plant materials and finished herbal medicinal products have become a major concern for health authorities, pharmaceutical industries as well as to the public. Presently, plenty of clinical trials are being conducted on herbal medicines; however, absence of harmonized classification has led to various confusions. The most important concern is the disputed identity of ayurvedic formulations sold under different brand names in different regions of the country and world. Recently, allopathic medicines have been classified by WHO on the basis of ATC/DDD (Anatomical- Therapeutic-Chemical/Daily Defined Dose) pattern of classification. The absence of such type of classification for ayurvedic products creates a situation of non recognition of these products in the international market. Hence there is a need to develop a classification system that is on the lines of ATC/DDD so that particular herb may qualify a product to be recognised under one name all over the world. Materials and Methods: Keeping in view the above scenario, a classification system is being proposed for ayurvedic products. The ayurvedic formulations and their site of action have been searched from various Ayurvedic texts. Internet sources such as Pubmed, Google Scholar, JSTOR etc. Results: The major reason for adopting similar classification for herbal medicines is that ayurvedic texts given by various scholars are published in Sanskrit or in the local/regional languages which make it difficult for the researchers to access, understand and interpret the knowledge shared. Conclusion: It is utmost important to generate such classification for herbal medicines as it will generate a classification data which can further be exploited for safety, efficacy as well as quality control purposes. Moreover, innovative classification will be helpful to provide standardized as well as a uniform way to classify the various herbal drugs and to generate new avenues for further ayurvedic research with more degree of precision. The classification will enable a product to be known under one banner/name at international level. Since the market is flooded with formulations related with neural disorders, hence herbal products used in neural disorders have been taken in the first phase.
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Gafforelli, Leonardo Gonçalves, Giuseppa Filippello, Mary Ellen Toffle, and Antonina Viviana Mafodda. "THE ATTACHMENT STYLE AND EMOTIONAL EXPERIENCE OF UNIVERSITY FOREIGN STUDENTS OF THE UNIVERSITY OF MESSINA." Revista Conhecimento Online 2 (May 28, 2020): 17. http://dx.doi.org/10.25112/rco.v2i0.2122.
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RESUMOEste trabalho relata a pesquisa que foi objeto da tese de mestrado de um estudante brasileiro, formado pela Universidade de Messina em Psicologia Clínica e da Saúde no Ciclo de Vida - A. A. 2018/2019. Estudar no exterior não é uma escolha simples. Os estudantes que decidem enfrentar esse tipo de experiência encontram grandes desafios cognitivos, físicos e pessoais. Esse tipo de mudança pode expor o aluno à vulnerabilidade emocional, favorecendo o surgimento de dificuldades, como gerenciar tarefas diárias, lidar com a carga de estudos, exames e gestão do dinheiro (FORBES-MEWETT; SAWYER, 2016). O objetivo da pesquisa foi examinar a relação entre estilo de apego e experiência emocional em uma amostra de estudantes universitários estrangeiros; especificamente sintomas relacionados à ansiedade de separação e sintomas depressivos. O estudo envolveu 80 estudantes estrangeiros da Universidade de Messina matriculados em um curso de três anos; mestrado ou doutorado. Os participantes responderam a um questionário estruturado relacionado à experiência de estudar no exterior, um instrumento que verificava o estilo de apego (Revised attachment scale for adults - Version for close relationships, Collins, 1996); um instrumento que avaliava a presença de sintomas de ansiedade (Measure of severity for separation anxiety disorder – adult, APA, 2013) e um instrumento para verificar a presença de sintomas de depressão (Beck Depression Inventory II, Beck, Steer e Brown, 1967). Os resultados desta pesquisa oferecem ideias para melhorar os serviços oferecidos aos estudantes estrangeiros, a fim de incentivar a integração na Universidade de Messina e o bom resultado dos estudos.Palavras-chave: Apego. Estudantes estrangeiros. Ansiedade. Depressão. ABSTRACTThis work reports the research that was the subject of the master’s thesis of a Brazilian student, graduated from the University of Messina in Clinical and Health Psychology in the Life Cycle - A. A. 2018/2019. Studying abroad is not a simple choice. Students who decide to face this type of experience undergo great cognitive, physical and personal challenges. This type of change can expose the student to emotional vulnerability, favoring the onset of difficulties such as managing daily tasks, coping with the load of studies, exams and money management (Forbes-Mewett & Sawyer, 2016). The objective of the research was to examine the relationship between attachment style and emotional experience in a sample of university foreign students; specifically symptoms related to separation anxiety and depressive symptoms. The study involved 80 foreign students enrolled at the University of Messina in a three-year degree course; master degree or Ph.D. Participants answered a structured questionnaire related to their experience of studying abroad, as well as an instrument that checked the attachment style (Revised attachment scale for adults - Version for close relationships, Collins, 1996); an instrument that assessed the presence of anxiety symptoms (Measure of severity for separation anxiety disorder - adult, APA, 2013) and an instrument to verify the presence of depression symptoms (Beck Depression Inventory – II, Beck, Steer e Brown, 1967). The results of this research offer ideas for improving the services offered to foreign students, in order to encourage integration at the University of Messina and the successful outcome of studies.Keywords: Attachment. Foreign students. Anxiety. Depression.
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Rothstein, Jules M. "Journeys Beyond the Horizon." Physical Therapy 81, no. 11 (November 1, 2001): 1817–28. http://dx.doi.org/10.1093/ptj/81.11.1817.
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Jules M Rothstein, clinician, researcher, educator, author, and speaker, entered into the field of physical therapy in 1975 following graduation from the Department of Physical Therapy at New York University. He completed his Master of Arts Degree in Kinesiology in 1979 and his Doctor of Philosophy in Physical Therapy in 1983, also at New York University. During his training, he worked as Staff Physical Therapist at Peninsula Hospital Center in Queens, as Research Fellow with the Arthritis Foundation, and in private practice in Cedarhurst, New York. From 1977 to 1980, Dr Rothstein was Adjunct Instructor in the Department of Physical Therapy at New York University. From 1980 to 1983, he was Instructor and Coordinator of Clinical Research and Training Programs at Washington University School of Medicine, and from 1984 to 1990, he was Associate Professor at the Medical College of Virginia. A tenured professor at the University of Illinois at Chicago since 1990, Dr Rothstein also served as Head of the Department of Physical Therapy at the University of Illinois at Chicago and as Chief of Physical Therapy Services at the University of Illinois Hospital in Chicago until 1999. During that period, the department obtained more than $6 million in research funding and received APTA's 1997 Minority Initiative Award for consistently recruiting and maintaining ethnic and racial diversity among its students. He continues to serve as Professor in the Department of Physical Therapy and remains active in all areas of physical therapy, practice, research, and service. Dr Rothstein's expertise in measurement and research design has been used by many professionals—across disciplines—in the allied health community. He is in great demand as an invited guest speaker, having given professional presentations and keynote speeches on the topic of rehabilitation sciences at numerous national and international forums, including Sweden, Denmark, Iceland, Japan, and Saudi Arabia. He has also served as a consultant and visiting professor in South Africa, the Netherlands, and Poland. Dr Rothstein has made extensive contributions to the physical therapy profession's body of knowledge, including the publication of more than 60 refereed articles and abstracts. In 1985, he edited the text Measurement in Physical Therapy. He chaired the APTA Task Force on Standards for Measurement in Physical Therapy that produced the first APTA Standards for Tests and Measurements in Physical Therapy Practice in 1993. As part of that task force, he co-authored the Primer on Measurement: An Introductory Guide to Measurements Issues. Since 1989, Dr Rothstein has served as Editor of Physical Therapy and has been appointed to that position for three 5-year terms by the APTA Board of Directors. Dr Rothstein is a Catherine Worthingham Fellow of the American Physical Therapy Association. He is the recipient of numerous awards, including the Golden Pen Award, the Outstanding Service Award for Research, the Outstanding Service Award for Continuing Education, and the Outstanding Therapist Award in the State of Illinois. [Rothstein JM. Thirty-Second Mary McMillan Lecture: Journeys beyond the horizon. Phys Ther. 2001;81:1817–1829.]