Academic literature on the topic 'Degree Discipline: Cognitive and Behavioural Neuroscience'

As an emerging discipline, neuroeconomics faces considerable methodological and practical challenges. In this paper, I suggest that these challenges can be understood by exploring the similarities and dissimilarities between the emergence of neuroeconomics and the emergence of cognitive and computational neuroscience two decades ago. From these parallels, I suggest the major challenge facing theory formation in the neural and behavioural sciences is that of being under-constrained by data, making a detailed understanding of physical implementation necessary for theory construction in neuroeconomics. Rather than following a top-down strategy, neuroeconomists should be pragmatic in the use of available data from animal models, information regarding neural pathways and projections, computational models of neural function, functional imaging and behavioural data. By providing convergent evidence across multiple levels of organization, neuroeconomics will have its most promising prospects of success.

Abstract This article presents a novel approach to the study of primate personality and illustrates it with a study of capuchin monkeys. While most personality studies with capuchin monkeys have used rating questionnaires, the research method of this study relies instead on direct behaviour observations. In an effort to capitalize on the full richness of behavioural observation data, we used both statistical and non-statistical methods to analyse data from behavioural observations of a group of capuchin monkeys in captivity. Interest in capuchin monkeys as a species has increased due to their cognitive capacities, behavioural flexibility and complex social structure, as well as many similarities with great apes in dimensions of personality. In this study we focus in three aspects of personality: diversity, flexibility and complexity. Our results provide a detailed picture of these aspects of capuchins’ personality, including the degree of “predictability” and “unusualness” of individual capuchins’ behaviour.

This paper critically examines the recent impact of cognitivism upon the field of clinical psychology, and concludes that certain criteria of scientific adequacy have been compromised. The argument is developed that the introduction of information processing constructs to theoretical models of psychopathology has made a potentially valuable contribution to the discipline; but that the acceptance of mental events as dependent measures has severely undermined the scientific credibility of experimental attempts to evaluate such models. It is proposed that future progress will require the adoption of a particular methodological constraint. Specifically, it is suggested that cognitive explanations of psychopathology can only be tested adequately by evaluating the validity of the behavioural predictions that they generate. Using examples of recent research that has investigated the cognitive characteristics of vulnerability to anxiety and depression, an attempt is made to demonstrate that adherence to this proposed constraint not only is possible, but actually provides a far greater degree of understanding than could be attained through the use of alternative methodologies. It is postulated that the future scientific status of clinical psychology may depend upon our collective response to the issues that are raised in this paper.

Since the 1970s, social psychology has examined real human behaviour to an increasingly smaller degree. This article is an analysis of the reasons why this is so. The author points out that the otherwise valuable phenomenon of cognitive shift, which occurred in social psychology precisely in the 1970s, naturally boosted the interest of psychologists in such phenomena like stereotypes, attitudes, and values; at the same time, it unfortunately decreased interest in others, like aggression, altruism, and social influence. In recent decades, we have also witnessed a growing conviction among psychologists that explaining why people display certain reactions holds greater importance than demonstrating the conditions under which people display these reactions. This assumption has been accompanied by the spread of statistical analysis applied to empirical data, which has led to researchers today generally preferring to employ survey studies (even if they are a component of experiments being conducted) to the analysis of behavioural variables. The author analyses the contents of the most recent volume of “Journal of Personality and Social Psychology”, and argues that it is essentially devoid of presentations of empirical studies in which human behaviours are examined. This gives rise to the question of whether social psychology remains a science of behaviour, and whether such a condition of the discipline is desirable.

Several techniques to assisting in the drug design and discovery stages have been developed during the last several decades. The bulk of these techniques aimed to find novel chemical entities that had the greatest significant interaction with the targeted receptors or enzymes while providing the least degree of risk of unwanted interactions. This approach, on the other hand, is time-consuming and expensive, as it requires the screening of thousands of molecules for biological activity, with only one making it to market. The prodrug strategy, in which the active drug molecule is disguised by a promoiety to change its undesirable characteristics, is one of the most appealing and promising methods. The folate receptor (FR)-targeted systems may also open the path for more advanced drug conjugates, especially because this receptor is now being targeted by a variety of technological innovations, including nanoparticles, small molecules, and protein-based technologies, resulting in a wealth of experience in the discipline.

Abstract (1) An assessment of the structure of time perspective (TP) in a group of patients with neurotic and personality disorders (ICD-10: F4x, F60.x, F61) treated with group psychotherapy. (2) An analysis of the differences between the structure of TP in patients and the general population in order to expand the understanding of the relations between TP and mental health. Data were collected from 49 patients at the University Hospital Day Centre for the Treatment of Neurotic Disorders and Behavioural Syndromes. The measurement of TP was performed with the Zimbardo Time Perspective Inventory. A licensed psychiatrist conducted the diagnosis of neurotic and personality disorders, with additional data obtained from the Symptom Checklist KO ‘O’ and the Neurotic Personality Questionnaire KON-2006. The statistical analysis revealed significant differences in the structure of TP between patients and the general population. Among patients, the intensity of the past experienced negatively was significantly higher, and subsequently, the degree of the past experienced positively was lower. Patients remain in the negative past and concentrate much more on the pain and the worrying memories. They give much less attention to what was and what is valuable and pleasant in their life. Results of this research reveal distinct features of the structure of TP in the studied group. Findings underline the clinical relevance of TP at various stages of therapy. Restoring a balanced time perspective could be regarded as a tenable goal for psychotherapy and perhaps an innovative indicator of the treatment’s effectiveness.

AbstractMountain gorillas use elaborate, multi-stage procedures for dealing with plant defences. This paper investigates the use of mathematically-inspired, informational measures to gauge the complexity of one of these tasks, eating thistle Carduus nyassanus, from field observations of 38 adults and juveniles. Behaviour was analysed at two levels, a detailed, movementbased description of the form of actions, and an organizational description of techniques that were composed of a series of many actions. Complexity, as measured by counting the sizes of behavioural repertoires, correlated at the two levels. Repertoires were shown to be incomplete, but the rates of cumulative increase in actions differed between tasks. Thistle eating was the most complex, and apparently involved many more actions than even chimpanzee tool-use. Techniques were highly selective arrangements of actions, so that their organization (sequence, bimanual coordination, hierarchical structure) reflected cognitive capacity. Although ideally it would preferable to estimate complexity of task organization, this may seldom be feasible, and was not in this case. Instead, the length of a regularly occurring sequence of actions may be the best practical estimate of an underlying complexity of mental process. Confidence in this measure will be increased if it broadly agrees with other, independent estimates of task complexity; in the case of gorilla plant processing, both the size of repertoire of functionally distinct actions and the degree of lateral specialization were, like sequence length, greater for thistle processing than for other tasks studied to date.

This project aims to optimise outcomes for children with cerebral palsy (CP) and their families by testing the efficacy of two complementary interventions novel to the CP population: (1) parenting intervention (Stepping Stones Triple P, SSTP); and (2) parental stress management (Acceptance and Commitment Therapy, ACT) tailored for parents of children with CP. The efficacy of SSTP and the additional effects of ACT will be tested in a wait-list randomised controlled trial, with parents of children with CP (N= 110) randomised into three groups; SSTP, SSTP + ACT and wait-list control. Intervention delivery will combine group sessions with phone consultations. Outcomes will be assessed post-intervention with retention of effect examined at 6-month follow-up. Child outcomes will include: externalising behaviour (primary child outcome), functional performance, parent-reported child quality of life; and parent outcomes will include: dysfunctional parenting (primary parent outcome), parental confidence in performing disability-related parenting practices, degree of problems in performing disability-related parenting practices, parental adjustment, psychological flexibility and parental attitude to child emotions. The theoretical background, study design and study procedures are discussed. The validation of a parenting intervention and a parenting stress intervention for parents of children with CP is crucial to better support parents of children with CP in their parenting role and in providing evidence-based intervention for behavioural and emotional problems in children with CP.

Despite the desire to delve deeper into hallucinations of all types, methodological obstacles have frustrated development of more rigorous quantitative experimental techniques, thereby hampering research progress. Here, we discuss these obstacles and, with reference to visual phenomena, argue that experimentally induced phenomena (e.g. hallucinations induced by flickering light and classical conditioning) can bring hallucinations within reach of more objective behavioural and neural measurement. Expanding the scope of hallucination research raises questions about which phenomena qualify as hallucinations, and how to identify phenomena suitable for use as laboratory models of hallucination. Due to the ambiguity inherent in current hallucination definitions, we suggest that the utility of phenomena for use as laboratory hallucination models should be represented on a continuous spectrum, where suitability varies with the degree to which external sensory information constrains conscious experience. We suggest that existing strategies that group pathological hallucinations into meaningful subtypes based on hallucination characteristics (including phenomenology, disorder and neural activity) can guide extrapolation from hallucination models to other hallucinatory phenomena. Using a spectrum of phenomena to guide scientific hallucination research should help unite the historically separate fields of psychophysics, cognitive neuroscience and clinical research to better understand and treat hallucinations, and inform models of consciousness. This article is part of the theme issue ‘Offline perception: voluntary and spontaneous perceptual experiences without matching external stimulation’.

Prof. Zeman trained in Medicine at Oxford University Medical School, after a first degree in Philosophy and Psychology, and later in Neurology in Oxford, at The National Hospital for Neurology in Queen Square, London and Addenbrooke’s Hospital, Cambridge. He moved to Edinburgh in 1996, as a Consultant and Senior Lecturer (later Reader) in the Department of Clinical Neurosciences and to the Peninsula Medical School (now University of Exeter Medical School) in September 2005 as Professor of Cognitive and Behavioural Neurology. His specialised clinical work is in cognitive and behavioural neurology, including neurological disorders of sleep.His main research interests are disorders of visual imagery and forms of amnesia occurring in epilepsy. He has an active background interest in the science and philosophy of consciousness, publishing a wide-ranging review of the field in Brain (2001; 124:1263–1289) and an accessible introduction to the subject for a general readership (Consciousness: a user’s guide, Yale University Press, 2002). In 2008 he published an introduction to neurology for the general reader, A Portrait of the Brain (Yale UP), and in 2012, Epilepsy and Memory (OUP) with Narinder Kapur and Marilyn Jones-Gotman. From 2007–2010 he was Chairman of the British Neuropsychiatry Association. He launched and continues to direct its training course in neuropsychiatry.For most of us visual imagery is a conspicuous ingredient of the imaginative experience which allows us to escape from the here and now into the past, the future and the worlds conceived by science and art. But there appears to be wide inter-individual variation in the vividness of visual imagery. Although the British psychologist Galton together with the Parisian neurologist Charcot and his psychiatrist colleague Cotard - recognised that some individuals may lack wakeful imagery entirely, the existence of ‘extreme imagery’ has been oddly neglected since this early work. In 2015 we coined the term ‘aphantasia’ to describe the lack of the mind’s eye, describing 21 individuals who reported a lifelong inability to visualise (Cortex, 2015;73:378–80). Since then we have heard from around 14,000 people, most reporting lifelong aphantasia, or its converse hyperphantasia, but also less common ‘acquired’ imagery loss resulting from brain injury or psychological disorder. Preliminary analyses suggests association between vividness extremes, occupational preference and reported abilities in face recognition and autobiographical memory. Many people with lifelong aphantasia nevertheless dream visually. Imagery in other modalities is variably affected. Extreme imagery appears to run in families more often than would be expected by chance. I will describe the findings of our recent pilot study of neuropsychological and brain imaging signatures of extreme imagery, and place our study of a- and hyper-phantasia in the context of the Eye’s Mind project, an interdisciplinary collaboration funded by the AHRC (http://medicine.exeter.ac.uk/research/neuroscience/theeyesmind/). In addition to our work on extreme imagery, we have reviewed the intellectual history of visual imagery (MacKisack et al, Frontiers in Psychology, 515:1–16. doi: 10.3389/fpsyg.2016.00515), undertaken a recent ALE meta-analysis of functional imaging studies of visualisation (Winlove et al, Cortex, 20182018; 105:4–25) and organised an exhibition of work by artists with extreme imagery vividness (Extreme Imagination: inside the mind’s eye Exeter University Press, 2018.)