Journal articles on the topic 'Degree Discipline: Biomedical Genetics'
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Xenophontos, Stavroulla, Margarita Zachariou, Pavlos Polycarpou, Elena Ioannidou, Vera Kazandjian, Maria Lagou, Anna Michaelidou, George M. Spyrou, Marios A. Cariolou, and Leonidas Phylactou. "The Cyprus Institute of Neurology and Genetics, an emerging paradigm of a gender egalitarian organisation." PLOS ONE 17, no. 9 (September 15, 2022): e0274356. http://dx.doi.org/10.1371/journal.pone.0274356.
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Females are underrepresented in the science, technology, engineering, mathematics and medicine (STEMM) disciplines globally and although progress has been made, the gender gap persists. Our aim was to explore gender parity in the context of gender representation and internal collaboration at the Cyprus Institute of Neurology and Genetics (CING), a leading national biomedical organisation accredited as an equal opportunity employer. Towards this aim we (1) explored trends in gender parity within the different departments, positions and qualifications and in student representation in the CING’s postgraduate school and, (2) investigated the degree of collaboration between male and female researchers within the Institute and the degree of influence within its co-authorship network. We recorded an over-representation of females both in the CING employees and the postgraduate students. The observed female over-representation in pooled CING employees was consistent with a similar over-representation in less senior positions and was contrasted with an observed male over-representation in only one middle rank and culminated in gender equality in the top rank in employee hierarchy. In terms of collaboration, both males and females tended to collaborate with each other without any significant preference to either inter-group or intra-group collaboration. Further comparison of the two groups with respect to their influence in the network in terms of occupying the positions of highest centrality scores, indicated that both gender and seniority level (head vs non-head) were significant in shaping the authors’ influence, with no significant difference in those belonging in the same seniority level with respect to their gender. To conclude, our study has validated the formal recognition of the CING’s policies and procedures pertinent to its egalitarian culture through the majority of the metrics of gender equality assessed in this study and has provided an extendable paradigm for evaluating gender parity in academic organizations.
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Sharpe, Eva. "A degree of choice." Biochemist 33, no. 4 (August 1, 2011): 54–55. http://dx.doi.org/10.1042/bio03304054.
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Students choosing courses in chemistry, physics and engineering can opt for degrees that are accredited by the relevant professional body. With the exception of biomedical science courses, students who are choosing biological science degrees don't currently have that option.
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Parciak, Marcel, Theresa Bender, Ulrich Sax, and Christian Robert Bauer. "Applying FAIRness: Redesigning a Biomedical Informatics Research Data Management Pipeline." Methods of Information in Medicine 58, no. 06 (December 2019): 229–34. http://dx.doi.org/10.1055/s-0040-1709158.
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Abstract Background Managing research data in biomedical informatics research requires solid data governance rules to guarantee sustainable operation, as it generally involves several professions and multiple sites. As every discipline involved in biomedical research applies its own set of tools and methods, research data as well as applied methods tend to branch out into numerous intermediate and output data objects, making it very difficult to reproduce research results. Objectives This article gives an overview of our implementation status applying the Findability, Accessibility, Interoperability and Reusability (FAIR) Guiding Principles for scientific data management and stewardship onto our research data management pipeline focusing on the software tools that are in use. Methods We analyzed our progress FAIRificating the whole data management pipeline, from processing non-FAIR data up to data usage. We looked at software tools for data integration, data storage, and data usage as well as how the FAIR Guiding Principles helped to choose appropriate tools for each task. Results We were able to advance the degree of FAIRness of our data integration as well as data storage solutions, but lack enabling more FAIR Guiding Principles regarding Data Usage. Existing evaluation methods regarding the FAIR Guiding Principles (FAIRmetrics) were not applicable to our analysis of software tools. Conclusion Using the FAIR Guiding Principles, we FAIRificated relevant parts of our research data management pipeline improving findability, accessibility, interoperability and reuse of datasets and research results. We aim to implement the FAIRmetrics to our data management infrastructure and—where required—to contribute to the FAIRmetrics for research data in the biomedical informatics domain as well as for software tools to achieve a higher degree of FAIRness of our research data management pipeline.
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Pettini, Francesco, Anna Visibelli, Vittoria Cicaloni, Daniele Iovinelli, and Ottavia Spiga. "Multi-Omics Model Applied to Cancer Genetics." International Journal of Molecular Sciences 22, no. 11 (May 27, 2021): 5751. http://dx.doi.org/10.3390/ijms22115751.
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In this review, we focus on bioinformatic oncology as an integrative discipline that incorporates knowledge from the mathematical, physical, and computational fields to further the biomedical understanding of cancer. Before providing a deeper insight into the bioinformatics approach and utilities involved in oncology, we must understand what is a system biology framework and the genetic connection, because of the high heterogenicity of the backgrounds of people approaching precision medicine. In fact, it is essential to providing general theoretical information on genomics, epigenomics, and transcriptomics to understand the phases of multi-omics approach. We consider how to create a multi-omics model. In the last section, we describe the new frontiers and future perspectives of this field.
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Wagner, PhD, BCE, ME, Vaughn E., and Elichia A. Venso, PhD. "Chemical and bioterrorism: An integrated emergency management approach at the undergraduate level." Journal of Emergency Management 2, no. 4 (October 1, 2004): 50. http://dx.doi.org/10.5055/jem.2004.0045.
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The accredited Environmental Health Science BS degree program at Salisbury University, a member institution of the University System of Maryland, has developed an integrated chemical and bioterrorism course for undergraduate students and emergency management professionals. The one-credit class meets once a week. Course design is adapted from the Federal Emergency Management Agency’s (FEMA) integrated approach to chemical and bioterrorist defensive training strategies. Course objectives are to gain knowledge of specific chemical and biological agents; become familiar with peacetime equivalents and surrogate agents; understand biomedical and environmental factors related to agent exposures; become familiar with integrated response strategies; and gain understanding of government policy issues, agency coordination, and field operations.Student input is based on specific discipline group response and participation in a simulated bioagent release. Discipline groups include public and emergency health, media, critical incident stress analysis, and conflict resolution. Student evaluations of the first course offered in the fall semester of 2002 indicated that the simulated release exercise gave each student an increased awareness of multiagency response necessary to mitigate bioterrorist-initiated events. Evaluation results also suggested the following modifications: include at least one community professional in each discipline group, extend the course to two credits, and schedule the class in late afternoon to accommodate working professionals.
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Poon, Randy Y. C. "Biomedical research in Hong Kong." Biochemist 33, no. 5 (October 1, 2011): 24–25. http://dx.doi.org/10.1042/bio03305024.
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The first paper from China published in a journal of the Biochemical Society is from as early as 1926. Ernest Tso from the Peking Union Medical College published in the Biochemical Journal a study on the stability of vitamins in Pidan 1. ‘Pidan’ are preserved duck eggs (also called century eggs, thousand-year eggs or millennium eggs, depending on the degree of exaggeration). The yolk (dark green, by the way) is encased in a white that resembles amber. A rather popular cuisine ingredient, Pidan, as nicely observed by Tso “… is perhaps as much used on the table as is cheese in Western countries”.
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Troy, Jesse D., Megan L. Neely, Steven C. Grambow, and Gregory P. Samsa. "The Biomedical Research Pyramid: A Model for the Practice of Biostatistics." Journal of Curriculum and Teaching 10, no. 1 (February 9, 2021): 10. http://dx.doi.org/10.5430/jct.v10n1p10.
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Biostatisticians apply statistical methods to solve problems in the biological sciences. Successful practioners of biostatistics have advanced technical knowledge, are skilled communicators, and can seamlesslessly integrate with interdisciplinary scientific teams. Despite the breadth of skills required for success in this field, most biostatistics education programs place heavier emphasis on development of technical skills than skills necessary for collaborative work, including critical thinking, writing, and public speaking. Our master’s degree program in biostatistics aims for stronger integration of education in collaborative work alongside development of technical knowledge in biostatistics. Toward that end, we propose a model that provides students with a mental map for practicing biostatistics, and that can serve as a tool for faculty to create hands-on learning experiences for biostatistics students. The model helps students organize their knowledge of biostatistics, unifying the technical and collaborative aspects of the discipline in a single framework that can be applied across the broad array of activities that biostatisticians engage in. In this article we describe the model in detail and provide an initial assessment of whether the model might meet its intended purpose by applying the model to a common task for practicing biostatisticians and biostatistics students: describing the results of a medical research study.
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Pessoa et al, R. G. G. "INTERACTIVE SEMINARS IN BIOCHEMISTRY DISCIPLINE FOR UNDERGRADUATE DEGREE IN BIOMEDICINE: BENEFITS AND PROBLEMS OF CARBOHYDRATES ASSOCIATED WITH MODERN LIFE." Revista de Ensino de Bioquímica 13 (August 24, 2015): 12. http://dx.doi.org/10.16923/reb.v13i2.580.
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The present project is part of the course in biochemistry for biomedical undergraduate students of the Federal University of Pernambuco - UFPE, which comprises theoretical and practical classes and interactive seminars prepared by students on studied topics to supplement learning. The aim of this research was to encourage students to innovate their search for knowledge, presenting an interactive strategy to demonstrate the importance of carbohydrates, as well as other energy fuels, for undergraduates students attending classes of biochemistry at the first semester at the university, in order to clarify the importance of maintaining a healthy way of life. The methodology used was a field research, documented in videos in which the opinions of a few people were registered in different places, such as in a fast-food restaurant, on the importance of carbohydrates. Records acquired were associated with a slide presentation on the subject, based on scientific books and articles, which were presented to the students of the discipline. It was also developed a dynamic to illustrate the consumption of carbohydrates in daily life and in different situations. After the project exhibition, a review of the research was conducted to the audience to express innovations or additions to their pre-existing concepts, on consumption of carbohydrates. The results of our work were very promising and the main goal of the project was achieved, since 88.2% of the respondents said there was an improvement in their knowledge, both theoretical and practical, on the subject, while only 11.8% reported no improvement at all. In conclusion, there was a greater involvement of students during the presentation of the subject and a higher participation during the group dynamic on the consumption of carbohydrates.
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Nerio, Ron, Althea Webber, Effie MacLachlan, David Lopatto, and Avrom J. Caplan. "One-Year Research Experience for Associate’s Degree Students Impacts Graduation, STEM Retention, and Transfer Patterns." CBE—Life Sciences Education 18, no. 2 (June 2019): ar25. http://dx.doi.org/10.1187/cbe.19-02-0042.
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The CUNY Research Scholars Program (CRSP) provides a yearlong faculty-mentored research experience to associate’s degree students. The program takes place at all 10 associate’s degree–granting colleges within the City University of New York system. We report on a mixed-methods study of 500 students who participated in the program during its initial 3 years. Quantitative longitudinal assessments revealed that students who engaged in CRSP were more likely to be retained in a science, technology, engineering, and mathematics (STEM) discipline or to graduate with a STEM degree than their counterparts in a matched comparison group. Furthermore, students who participated in CRSP demonstrated an increased likelihood of transferring to the more research-intensive 4-year schools within the CUNY system and to R1 universities outside the CUNY system. CRSP students reported an increased sense of belonging in college based on survey data, and focus groups with their mentors provided insight into the factors that led to the gains listed above. These combined results—of student data analysis, student surveys, and mentor focus groups—provide evidence that early research experiences for associate’s degree students contribute to their academic success.
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McGivern, Gerry, and Sue Dopson. "Inter-epistemic Power and Transforming Knowledge Objects in a Biomedical Network." Organization Studies 31, no. 12 (December 2010): 1667–86. http://dx.doi.org/10.1177/0170840610380808.
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We examine a multidisciplinary network established to translate genetics science into practice in the British NHS. Drawing on theory about epistemic communities and objects, we describe three stages in their lifecycle (vision/formation, transformation and reincarnation) and epistemic clashes over knowledge objects. Medical academics captured jurisdiction over the network at formation, through their superior knowledge of the nascent genetics discipline, producing epistemic objects reflecting their interests. A governmental community challenged medical academics for jurisdiction but, unable to transform objects by changing their space of representation in performance reporting, ceased funding the network, which then closed. Afterwards, however, a NHS community successfully ‘reincarnated’ a discarded epistemic object into a technical object in NHS practice. We make a theoretical contribution by developing a processual framework for understanding biomedical innovation, focusing on transforming objects situated between different wider knowledge/power structures. This explains how objects were transformed at micro-level through the interaction and relative power of local communities, influenced by macro-level rules about knowledge formation in wider epistemic, organizational and governmental communities.
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Dyer, Michael G. "Toward Synthesizing Artificial Neural Networks that Exhibit Cooperative Intelligent Behavior: Some Open Issues in Artificial Life." Artificial Life 1, no. 1_2 (October 1993): 111–34. http://dx.doi.org/10.1162/artl.1993.1.1_2.111.
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The tasks that animals perform require a high degree of intelligence. Animals forage for food, migrate, navigate, court mates, rear offspring, defend against predators, construct nests, and so on. These tasks commonly require social interaction/cooperation and are accomplished by animal nervous systems, which are the result of billions of years of evolution and complex developmental/learning processes. The Artificial Life (AL) approach to synthesizing intelligent behavior is guided by this biological perspective. In this article we examine some of the numerous open problems in synthesizing intelligent animal behavior (especially cooperative behavior involving communication) that face the field of AL, a discipline still in its infancy.
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Drinkwater, Michael J., Kelly E. Matthews, and Jacob Seiler. "How Is Science Being Taught? Measuring Evidence-Based Teaching Practices across Undergraduate Science Departments." CBE—Life Sciences Education 16, no. 1 (March 2017): ar18. http://dx.doi.org/10.1187/cbe.15-12-0261.
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While there is a wealth of research evidencing the benefits of active-learning approaches, the extent to which these teaching practices are adopted in the sciences is not well known. The aim of this study is to establish an evidential baseline of teaching practices across a bachelor of science degree program at a large research-intensive Australian university. Our purpose is to contribute to knowledge on the adoption levels of evidence-based teaching practices by faculty within a science degree program and inform our science curriculum review in practical terms. We used the Teaching Practices Inventory (TPI) to measure the use of evidence-based teaching approaches in 129 courses (units of study) across 13 departments. We compared the results with those from a Canadian institution to identify areas in need of improvement at our institution. We applied a regression analysis to the data and found that the adoption of evidence-based teaching practices differs by discipline and is higher in first-year classes at our institution. The study demonstrates that the TPI can be used in different institutional contexts and provides data that can inform practice and policy.
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Hart, Jack, and Caleb C. McKinney. "An institutional analysis of graduate outcomes reveals a contemporary workforce footprint for biomedical master’s degrees." PLOS ONE 15, no. 12 (December 7, 2020): e0243153. http://dx.doi.org/10.1371/journal.pone.0243153.
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There is continued growth in the number of master’s degrees awarded in the life sciences to address the evolving needs of the biomedical workforce. Academic medical centers leverage the expertise of their faculty and industry partners to develop one to two year intensive and multidisciplinary master’s programs that equip students with advanced scientific skills and practical training experiences. However, there is little data published on the outcomes of these graduates to evaluate the effectiveness of these programs and to inform the return on investment of students. Here, the authors show the first five-year career outlook for master of science graduates from programs housed at an academic medical center. Georgetown University Biomedical Graduate Education researchers analyzed the placement outcomes of 1,204 graduates from 2014–2018, and the two-year outcomes of 412 graduates from 2016 and 2017. From the 15 M.S. programs analyzed, they found that 69% of graduates entered the workforce, while 28% entered an advanced degree program such as a Ph.D., allopathic or osteopathic medicine (M.D. or D.O.), or health professions degree. International students who pursue advanced degrees largely pursued Ph.D. degrees, while domestic students represent the majority of students entering into medical programs. Researchers found that a majority of the alumni that entered the workforce pursue research-based work, with 59% of graduates conducting research-based job functions across industries. Forty-nine percent of employed graduates analyzed from 2016 and 2017 changed employment positions, while 15% entered advanced degree programs. Alumni that changed positions changed companies in the same job function, changed to a position of increasing responsibility in the same or different organization, or changed to a different job function in the same or different company. Overall, standalone master’s programs equip graduates with research skills, analytical prowess, and content expertise, strengthening the talent pipeline of the biomedical workforce.
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Bolt, Taylor, Jason S. Nomi, Danilo Bzdok, and Lucina Q. Uddin. "Educating the future generation of researchers: A cross-disciplinary survey of trends in analysis methods." PLOS Biology 19, no. 7 (July 29, 2021): e3001313. http://dx.doi.org/10.1371/journal.pbio.3001313.
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Methods for data analysis in the biomedical, life, and social (BLS) sciences are developing at a rapid pace. At the same time, there is increasing concern that education in quantitative methods is failing to adequately prepare students for contemporary research. These trends have led to calls for educational reform to undergraduate and graduate quantitative research method curricula. We argue that such reform should be based on data-driven insights into within- and cross-disciplinary use of analytic methods. Our survey of peer-reviewed literature analyzed approximately 1.3 million openly available research articles to monitor the cross-disciplinary mentions of analytic methods in the past decade. We applied data-driven text mining analyses to the “Methods” and “Results” sections of a large subset of this corpus to identify trends in analytic method mentions shared across disciplines, as well as those unique to each discipline. We found that the t test, analysis of variance (ANOVA), linear regression, chi-squared test, and other classical statistical methods have been and remain the most mentioned analytic methods in biomedical, life science, and social science research articles. However, mentions of these methods have declined as a percentage of the published literature between 2009 and 2020. On the other hand, multivariate statistical and machine learning approaches, such as artificial neural networks (ANNs), have seen a significant increase in the total share of scientific publications. We also found unique groupings of analytic methods associated with each BLS science discipline, such as the use of structural equation modeling (SEM) in psychology, survival models in oncology, and manifold learning in ecology. We discuss the implications of these findings for education in statistics and research methods, as well as within- and cross-disciplinary collaboration.
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Riabushko, O. B. "EPONYMOUS TERMS IN MEDICAL GENETICS." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 20, no. 1 (April 9, 2020): 172–76. http://dx.doi.org/10.31718/2077-1096.20.1.172.
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Reforming of higher medical education in Ukraine requires reconsidering of existing learning technologies and tools as well as creating the approaches meeting up-to-date demands in order to improve the professional training of highly qualified specialists who can compete in the global medical services market. Medical biology is one of the fundamental biomedical disciplines aimed at familiarizing students with concepts about the basic laws of functioning of living beings at all organizational levels. The knowledge students have gained when studying this discipline is of great practical importance, since theoretical material is associated with a range of clinical disciplines. Modern textbooks, manuals, dictionaries of scientific terms in medical biology contains many eponymous terms. These terms are also used in international publications. The eponymous terms are widely common in biology, anatomy, histology, cytology, embryology, physiology that enables to develop interdisciplinary integral relationships and contributes to the formation of a scientific worldview. The knowledge of these names and their appropriate usage even at the beginning of the special training of future doctors leads to an increase in the intellectual level, contributes to a deeper understanding of the scientific foundations of disciplines through the mastering professional terminology and the language of specialists. The clear perception of eponymous names from different branches of medicine is important for doctors of any speciality. This will facilitate their professional growth through communication with colleagues, help in working with special scientific literature, and stimulate the need for self-education and self-improvement. Eponymous terms are difficult to remember, difficult to transcribe and transliterate, but they help preserve traditions and history, glory the names of scientists and doctors who have made invaluable contributions to the development of medicine. The purpose of the publication is to analyze and highlight the role of eponymous terms that are used through the course of medical biology, in particular, the section of medical genetics, to focus on the structural features of these terminological units.
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Ben-yi, Li, Zhou Xi-cai, and Zhang Yong-shang. "The relationship between the energy levels of shock waves and the degree of renal damage after ESWL: A prospective clinical matching trail." Journal of Huazhong University of Science and Technology [Medical Sciences] 14, no. 2 (June 1994): 114–18. http://dx.doi.org/10.1007/bf02886787.
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Thompson, Nancy L., and Andrew G. Campbell. "Addressing the Challenge of Diversity in the Graduate Ranks: Good Practices Yield Good Outcomes." CBE—Life Sciences Education 12, no. 1 (March 2013): 19–29. http://dx.doi.org/10.1187/cbe.12-04-0054.
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In this paper, we examine the impact of implementing three systemic practices on the diversity and institutional culture in biomedical and public health PhD training at Brown University. We hypothesized that these practices, designed as part of the National Institutes of Health–funded Initiative to Maximize Student Development (IMSD) program in the Division of Biology and Medicine, would have a positive effect on underrepresented minority (URM) recruitment and retention and objective measures of student success. These practices include: 1) develop strategic partnerships with selected undergraduate institutions; 2) provide a personalized education program of student support and skill-based modules to supplement discipline-based course work; and 3) transform institutional culture by engaging faculty in supporting diversity-related goals and practices. Data comparing URM numbers and key academic milestones before and after implementation of IMSD practices support the initial hypothesis and effectiveness of these practices at Brown. Program components are broadly applicable as best practices for others seeking to improve URM recruitment and achievements of graduate students traditionally underrepresented in the sciences.
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Li, Jia, Zhu Xianglei, and Xu Guoliang. "Research status and development trend of altruism in the biological field - knowledge graph analysis based on CiteSpace." Journal of Biology and Medicine 6, no. 1 (December 1, 2022): 042–47. http://dx.doi.org/10.17352/jbm.000034.
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Based on the visualization analysis of foreign literature on altruistic behavior in recent ten years (2012-2022) by CiteSpace, it is found that the research on altruistic behavior in the field of biology abroad has experienced the initial exploratory stage, the outbreak stage, and now enters the stable and deepening stage. The discipline distribution is mainly behavioral ecology, supplemented by evolutionary biology, biomathematics, and genetics. The author has three main cooperative groups, and a relatively tight cooperative network has been formed locally in related fields. From the perspective of cooperation degree, the cooperation density of major research institutions is high, and relevant research has been relatively mature. Judging from the period calculated in the software, altruism, cooperation, kin Selection, reciprocity, and inclusive fitness emerged earlier. In recent years, constitutive theory, density dependence, and Habitat construction have emerged, which may become a new direction for future research. Therefore, future research can expand the scope of disciplines, strengthen the cooperation between authors and units, and explore other research hotspots.
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Graves, Joseph L. "The Myth of the Genetically Sick African." Genealogy 6, no. 1 (February 11, 2022): 15. http://dx.doi.org/10.3390/genealogy6010015.
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Western medicine has an unfortunate history where it has been applied to address the health of African Americans. At its origins, it was aligned with the objectives of colonialism and chattel slavery. The degree to which medical “science” concerned itself with persons of African descent was to keep them alive for sale on the auction block, or to keep them healthy as they toiled to generate wealth for their European owners. Medicine in early America relied upon both dead and live African bodies to test its ideas to benefit Europeans. As medicine moved from quackery to a discipline based in science, its understanding of human biological variation was flawed. This was not a problem confined to medicine alone, but to the biological sciences in general. Biology had no solid theoretical basis until after 1859. As medicine further developed in the 20th century, it never doubted the difference between Europeans and Africans, and also asserted the innate inferiority of the latter. The genomic revolution in the latter 20th century produced tools that were deployed in a biomedical culture still mired in “racial” medicine. This lack of theoretical perspective still misdirects research associated with health disparity. In contrast to this is evolutionary medicine, which relies on a sound unification of evolutionary (ultimate) and physiological, cellular, and molecular (proximate) mechanisms. Utilizing the perspectives of evolutionary medicine is a prerequisite for an effective intervention in health disparity and finally dispelling the myth of the genetically sick African.
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Mohamed, Sofia B., Sumaya Kambal, Sabah A. E. Ibrahim, Esra Abdalwhab, Abdalla Munir, Arwa Ibrahim, and Qurashi Mohamed Ali. "Bioinformatics in Sudan: Status and challenges case study: The National University-Sudan." PLOS Computational Biology 17, no. 10 (October 21, 2021): e1009462. http://dx.doi.org/10.1371/journal.pcbi.1009462.
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The ever increasing applications of bioinformatics in providing effective interpretation of large and complex biological data require expertise in the use of sophisticated computational tools and advanced statistical tests, skills that are mostly lacking in the Sudanese research community. This can be attributed to paucity in the development and promotion of bioinformatics, lack of senior bioinformaticians, and the general status quo of inadequate research funding in Sudan. In this paper, we describe the challenges that have encountered the development of bioinformatics as a discipline in Sudan. Additionally, we highlight on specific actions that may help develop and promote its education and training. The paper takes the National University Biomedical Research Institute (NUBRI) as an example of an institute that has tackled many of these challenges and strives to drive powerful efforts in the development of bioinformatics in the country.
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Kouskoumvekaki, Irene, and Gianni Panagiotou. "Navigating the Human Metabolome for Biomarker Identification and Design of Pharmaceutical Molecules." Journal of Biomedicine and Biotechnology 2011 (2011): 1–19. http://dx.doi.org/10.1155/2011/525497.
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Metabolomics is a rapidly evolving discipline that involves the systematic study of endogenous small molecules that characterize the metabolic pathways of biological systems. The study of metabolism at a global level has the potential to contribute significantly to biomedical research, clinical medical practice, as well as drug discovery. In this paper, we present the most up-to-date metabolite and metabolic pathway resources, and we summarize the statistical, and machine-learning tools used for the analysis of data from clinical metabolomics. Through specific applications on cancer, diabetes, neurological and other diseases, we demonstrate how these tools can facilitate diagnosis and identification of potential biomarkers for use within disease diagnosis. Additionally, we discuss the increasing importance of the integration of metabolomics data in drug discovery. On a case-study based on the Human Metabolome Database (HMDB) and the Chinese Natural Product Database (CNPD), we demonstrate the close relatedness of the two data sets of compounds, and we further illustrate how structural similarity with human metabolites could assist in the design of novel pharmaceuticals and the elucidation of the molecular mechanisms of medicinal plants.
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Mathieson, Iain, Federico Abascal, Lasse Vinner, Pontus Skoglund, Cristina Pomilla, Peter Mitchell, Charles Arthur, et al. "An Ancient Baboon Genome Demonstrates Long-Term Population Continuity in Southern Africa." Genome Biology and Evolution 12, no. 4 (February 5, 2020): 407–12. http://dx.doi.org/10.1093/gbe/evaa019.
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Abstract Baboons are one of the most abundant large nonhuman primates and are widely studied in biomedical, behavioral, and anthropological research. Despite this, our knowledge of their evolutionary and demographic history remains incomplete. Here, we report a 0.9-fold coverage genome sequence from a 5800-year-old baboon from the site of Ha Makotoko in Lesotho. The ancient baboon is closely related to present-day Papio ursinus individuals from southern Africa—indicating a high degree of continuity in the southern African baboon population. This level of population continuity is rare in recent human populations but may provide a good model for the evolution of Homo and other large primates over similar timespans in structured populations throughout Africa.
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Anderson, Gwen, and Mary Varney Rorty. "Key Points for Developing an International Declaration on Nursing, Human Rights, Human Genetics and Public Health Policy." Nursing Ethics 8, no. 3 (May 2001): 259–71. http://dx.doi.org/10.1177/096973300100800310.
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Human rights legislation pertaining to applications of human genetic science is still lacking at an international level. Three international human rights documents now serve as guidelines for countries wishing to develop such legislation. These were drafted and adopted by the United Nations Educational, Scientific and Cultural Organization, the Human Genome Organization, and the Council of Europe. It is critically important that the international nursing community makes known its philosophy and practice-based knowledge relating to ethics and human rights, and contributes to the globalization of genetics. Nurses have particular expertise because they serve in a unique role at grass roots level to mediate between genetic science and its application to public health policies and medical interventions. As a result, nurses worldwide need to focus a constant eye on human rights ideals and interpret these within social, cultural, economic and political contexts at national and local levels. The purpose of this article is to clarify and legitimate the need for an international declaration on nursing, human rights, human genetics and public health policy. Because nurses around the world are the professional workforce by which genetic health care services and genetic research protocols will be delivered in the twenty-first century, members of the discipline of nursing need to think globally while acting locally. Above all other disciplines involved in genetics, nursing is in a good position to articulate an expanded theory of ethics beyond the principled approach of biomedical ethics. Nursing is sensitive to cultural diversity and community values; it is sympathetic to and can introduce an ethic of caring and relational ethics that listen to and accommodate the needs of local people and their requirements for public health.
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Casad, Bettina J., Amy L. Chang, and Christine M. Pribbenow. "The Benefits of Attending the Annual Biomedical Research Conference for Minority Students (ABRCMS): The Role of Research Confidence." CBE—Life Sciences Education 15, no. 3 (September 2016): ar46. http://dx.doi.org/10.1187/cbe.16-01-0048.
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The Annual Biomedical Research Conference for Minority Students (ABRCMS) is designed to support undergraduate students’ professional development as future scientists. Juniors, seniors, and postbaccalaureates who attended ABRCMS during 2008–2011 were emailed a link to an online questionnaire in which they reported their experiences at the conference. Attendees reported many ABRCMS-provided benefits. Frequency of attending or presenting at ABRCMS is positively related to science self-efficacy, research confidence, sense of belonging in science, and intentions to pursue a research degree in graduate school. Increased research confidence predicts graduate school plans and intentions for a research career in science; however, men were slightly more likely to intend to pursue a research career than women, likely due to higher research confidence. Although all attendees benefited from ABRCMS, underrepresented minority (URM) students had higher science self-efficacy and sense of belonging in science after attending ABRCMS than non-URM students. This finding demonstrates the effectiveness of ABRCMS as an intervention to increase the representation and success of URMs in science. Results highlight the importance of attending a minority-oriented research conference where URMs can develop their science self-efficacy, research confidence, and sense of belonging in science. However, changes to the conference and undergraduate research experiences may be necessary to reduce gender gaps.
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Córdova-Martínez, Alfredo, Alberto Caballero-García, Hugo J. Bello, Daniel Perez-Valdecantos, and Enrique Roche. "Effects of Eccentric vs. Concentric Sports on Blood Muscular Damage Markers in Male Professional Players." Biology 11, no. 3 (February 22, 2022): 343. http://dx.doi.org/10.3390/biology11030343.
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Background: Repetitive eccentric contractions can lead to higher degree of damage compared to repetitive concentric contractions. However, this type of exercise does not reproduce the real situations during the season in competitive sport disciplines. Methods: We analyzed the pattern of muscle damage blood markers in male professionals from three disciplines: cycling (n = 18), mainly concentric, vs. basketball (n = 12) and volleyball (n = 14), both mainly eccentric. Circulating muscle markers were analyzed in two moments of the regular season: after a 20-day training (no competition) period (T1) and after a 20-day period of high demanding competition (T2). Results: Blood levels of creatine kinase and myoglobin (muscle markers) increased in all groups at T2 compared to T1 as a result of competition intensity. The lower increases were noticed in cyclists at the end of both periods. Testosterone levels decreased at T2 compared to T1 in all disciplines, with lower levels found in cyclists. However, cortisol plasma levels decreased in basketball and volleyball players at T2, but increased significantly in cyclists, suggesting a limited adaptation to the effort. Conclusions: The pattern of circulating muscle markers is different depending of the demanding efforts (training vs. competition) of each particular discipline.
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Zenebe, Chirotaw Getem. "A Review on the Role of Wollastonite Biomaterial in Bone Tissue Engineering." BioMed Research International 2022 (December 13, 2022): 1–15. http://dx.doi.org/10.1155/2022/4996530.
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Millions of people around the world have bone-tissue defects. Autologous and allogeneic bone grafting are frequent therapeutic techniques; however, none has produced the best therapeutic results. This has inspired researchers to investigate novel bone-regeneration technologies. In recent years, the development of bone tissue engineering (BTE) scaffolds has been at the forefront of this discipline. Due to their limitless supply and lack of disease transmission, engineered bone tissue has been advanced for the repair and reconstruction of bone deformities. Bone tissue is a highly vascularized, dynamic tissue that constantly remodels during an individual’s lifetime. Bone tissue engineering is aimed at stimulating the creation of new, functional bone by combining biomaterials, cells, and factor treatment synergistically. This article provides a review of wollastonite’s biomaterial application in bone tissue engineering. This work includes an explanation of wollastonite minerals including mining, raw materials for the synthesis of artificial wollastonite with various methods, its biocompatibility, and biomedical applications. Future perspectives are also addressed, along with topics like bone tissue engineering, the qualities optimal bone scaffolds must have, and the way a scaffold is designed can have a big impact on how the body reacts.
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Bourell, D. L., and H. L. Marcus. "The College-Wide Interdisciplinary Materials Science and Engineering Graduate Program." MRS Bulletin 15, no. 8 (August 1990): 46–48. http://dx.doi.org/10.1557/s0883769400058954.
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The college-wide interdisciplinary graduate program approach to graduate education is a viable alternative to the departmental structure for areas of study that span two or more traditional disciplines. This article will explore the nature of this organizational style using materials science and engineering as the example discipline. We will discuss the advantages and disadvantages of the graduate program approach in the light of more than 18 years of experience at the University of Texas at Austin.The primary task of any center for higher learning is the education of students in an environment conducive to the open exchange and dissemination of ideas and knowledge. Traditionally, the university has approached this task by assembling scholars with common foundations of expertise into a collective group, the department. Besides the obvious function of providing a structured setting for the concentration of scholars with similar interests, the department also serves as the front line of faculty governance for matters including tenure, promotion, salary, resource management, and distribution. For example, course content and degree requirements are initiated at the department level. Thus the organizational structure of the college, and hence of the university, is firmly built on the traditional concept of department, a concept that has served education well.However, there are liabilities to the departmental structure since its natural tendency is to compartmentalize knowledge with the concomitant academic provincialism. This mindset poses a particularly serious problem for a number of subject areas that are intrinsically multidisciplinary. Several examples in the field of engineering science are biomedical engineering, manufacturing and industrial engineering, nuclear engineering, environmental engineering and also materials science and engineering.
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Chistova, Viktoriya V., Ekaterina V. Logunova, Ksenia O. Pashinskaya, Elena M. Ryzhikova, Ekaterina D. Romanova, Alexander G. Vasiliev, and Alexander N. Udalov. "EFFECTIVE MANAGEMENT OF ARCTIC TOURISM SAFETY BASED ON BIOMEDICAL PREDICTIVE MODELS OF ADAPTATION TO EXTREME CONDITIONS." Siberian Journal of Life Sciences and Agriculture 13, no. 4 (August 31, 2021): 297–315. http://dx.doi.org/10.12731/2658-6649-2021-13-4-297-315.
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The article analyzes the literature on the organization of tourist health safety in the Arctic. The Arctic territories of the Russian Federation have the potential and prospects for the development of tourism. Some people staying for the purpose of tourism in the Arctic have a high degree of vulnerability to the action of natural environmental factors even when creating comfortable conditions, which is determined when assessing the level of health and the adaptive potential of the body. In the Arctic, there is a threat to health safety, which is expressed by a deterioration in the functional state and exacerbation of chronic diseases. Methods for assessing the psycho-functional state of the human body in the Arctic are presented, which make it possible to identify early adaptation disorders and determine the characteristics of chronic diseases. It is concluded that it is necessary, from the standpoint of an integrated approach, to study the level of health of tourists and develop a program that will prevent the development of maladjustment and associated pathological conditions. Maintaining the initial level of health and preventing the development of maladjustment and associated pathological conditions will contribute to ensuring health safety when a tourist is in the territories that are part of the Arctic and Arctic zones of the Russian Federation.
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McGlennen, Ronald C. "Miniaturization Technologies for Molecular Diagnostics." Clinical Chemistry 47, no. 3 (March 1, 2001): 393–402. http://dx.doi.org/10.1093/clinchem/47.3.393.
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Abstract Background: Molecular diagnostics devices are becoming smaller. With the advancement of miniaturization technologies, microchip-based systems will soon be available for genetic testing. The purpose of this review is to highlight the underlying principles in miniaturization, the strategies being developed for bioanalysis, and the potential impact on the practice of this rapidly growing medical discipline. Approach: The author discusses DNA microchips and their practical importation into the clinical laboratory, based on his background in medical device and microchip design and development. His discussion is supported by a body of literature covering both biomedical and electrical engineering and more recent publications in the field of molecular genetics and pathology. Content: This review is descriptive and intended to outline the technologic and methodologic approaches to the creation of an integrated genetic analysis instrument based on miniature components. The review draws on published scientific evaluations of these devices without regard to the companies involved in their development. Summary: The intent of this review is that the reader will better understand the variety of technical approaches toward the miniaturization of molecular genetic testing for the clinical laboratory. With insight into the principles underlying the operation of these chips and the integrated systems, the end user can better evaluate the value to the field in terms of making molecular genetics testing simpler, faster, and less expensive.
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Murray, Debra, and Susan Fernbach. "Abstract LB073: Improving early career faculty research programs: Underrepresented Biomedical Researcher Scholars Program." Cancer Research 82, no. 12_Supplement (June 15, 2022): LB073. http://dx.doi.org/10.1158/1538-7445.am2022-lb073.
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Abstract According to the U.S. Department of Education in Fall 2018, full-time faculty in degree-granting postsecondary institutions were ~40% White males; 35% White females; 7% Asian/Pacific Islander males; 5% Asian/Pacific Islander females; and 3% each Black males, Black females, Hispanic males, and Hispanic females.1 Under-representation is one of the barriers to success for African American and Hispanic faculty. Barriers to women’s career advancement from underrepresented groups in academic medicine, science, and engineering and obtaining external research funding support for African American faculty do not occur in a vacuum and co-exist with barriers to research productivity overall.2 This data establishes the necessity of increasing representation, creating more accessible research opportunities, building networks, mentoring relationships in STEM-related fields, obtaining a diverse scientific workforce, and ensuring the success of all underrepresented in biomedical research (UBR) trainees and early career faculty. The All of Us Evenings with Genetics (AoUEwG) Research Program provides training to support Early Career Faculty and Senior Postdoctoral fellowship in cancer research. This engagement program includes Evenings With Genetics seminars, where regional and national campus audiences will be introduced to research opportunities available through the All of Us research hub; the Underrepresented Biomedical Researcher Faculty Summit UBRFS), where summit attendees will take part in using the All of Us research hub and receive data science training and professional development; and the UBRFS Scholars Program, where conference participants will receive yearlong support after the summit, including monthly multidisciplinary research team meetings, quarterly meetings, and mentor support. The AoUEwG Research Program aims to increase research productivity among UBR early career faculty and support their promotion to the next career level. Citation Format: Debra Murray, Susan Fernbach. Improving early career faculty research programs: Underrepresented Biomedical Researcher Scholars Program [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr LB073.
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Stone, Robert J. "The (human) science of medical virtual learning environments." Philosophical Transactions of the Royal Society B: Biological Sciences 366, no. 1562 (January 27, 2011): 276–85. http://dx.doi.org/10.1098/rstb.2010.0209.
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The uptake of virtual simulation technologies in both military and civilian surgical contexts has been both slow and patchy. The failure of the virtual reality community in the 1990s and early 2000s to deliver affordable and accessible training systems stems not only from an obsessive quest to develop the ‘ultimate’ in so-called ‘immersive’ hardware solutions, from head-mounted displays to large-scale projection theatres, but also from a comprehensive lack of attention to the needs of the end users. While many still perceive the science of simulation to be defined by technological advances, such as computing power, specialized graphics hardware, advanced interactive controllers, displays and so on, the true science underpinning simulation—the science that helps to guarantee the transfer of skills from the simulated to the real—is that of human factors, a well-established discipline that focuses on the abilities and limitations of the end user when designing interactive systems, as opposed to the more commercially explicit components of technology. Based on three surgical simulation case studies, the importance of a human factors approach to the design of appropriate simulation content and interactive hardware for medical simulation is illustrated. The studies demonstrate that it is unnecessary to pursue real-world fidelity in all instances in order to achieve psychological fidelity—the degree to which the simulated tasks reproduce and foster knowledge, skills and behaviours that can be reliably transferred to real-world training applications.
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Cazzaniga, Alessandra, Claudia Moscheni, Jeanette AM Maier, and Sara Castiglioni. "Culture of human cells in experimental units for spaceflight impacts on their behavior." Experimental Biology and Medicine 242, no. 10 (December 14, 2016): 1072–78. http://dx.doi.org/10.1177/1535370216684039.
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Because space missions produce pathophysiological alterations such as cardiovascular disorders and bone demineralization which are very common on Earth, biomedical research in space is a frontier that holds important promises not only to counterbalance space-associated disorders in astronauts but also to ameliorate the health of Earth-bound population. Experiments in space are complex to design. Cells must be cultured in closed cell culture systems (from now defined experimental units (EUs)), which are biocompatible, functional, safe to minimize any potential hazard to the crew, and with a high degree of automation. Therefore, to perform experiments in orbit, it is relevant to know how closely culture in the EUs reflects cellular behavior under normal growth conditions. We compared the performances in these units of three different human cell types, which were recently space flown, i.e. bone mesenchymal stem cells, micro- and macrovascular endothelial cells. Endothelial cells are only slightly and transiently affected by culture in the EUs, whereas these devices accelerate mesenchymal stem cell reprogramming toward osteogenic differentiation, in part by increasing the amounts of reactive oxygen species. We conclude that cell culture conditions in the EUs do not exactly mimic what happens in a culture dish and that more efforts are necessary to optimize these devices for biomedical experiments in space. Impact statement Cell cultures represent valuable preclinical models to decipher pathogenic circuitries. This is true also for biomedical research in space. A lot has been learnt about cell adaptation and reaction from the experiments performed on many different cell types flown to space. Obviously, cell culture in space has to meet specific requirements for the safety of the crew and to comply with the unique environmental challenges. For these reasons, specific devices for cell culture in space have been developed. It is important to clarify whether these alternative culture systems impact on cell performances to allow a correct interpretation of the data.
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Brandt, Patrick D., Susi Sturzenegger Varvayanis, Tracey Baas, Amanda F. Bolgioni, Janet Alder, Kimberly A. Petrie, Isabel Dominguez, et al. "A cross-institutional analysis of the effects of broadening trainee professional development on research productivity." PLOS Biology 19, no. 7 (July 15, 2021): e3000956. http://dx.doi.org/10.1371/journal.pbio.3000956.
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PhD-trained scientists are essential contributors to the workforce in diverse employment sectors that include academia, industry, government, and nonprofit organizations. Hence, best practices for training the future biomedical workforce are of national concern. Complementing coursework and laboratory research training, many institutions now offer professional training that enables career exploration and develops a broad set of skills critical to various career paths. The National Institutes of Health (NIH) funded academic institutions to design innovative programming to enable this professional development through a mechanism known as Broadening Experiences in Scientific Training (BEST). Programming at the NIH BEST awardee institutions included career panels, skill-building workshops, job search workshops, site visits, and internships. Because doctoral training is lengthy and requires focused attention on dissertation research, an initial concern was that students participating in additional complementary training activities might exhibit an increased time to degree or diminished research productivity. Metrics were analyzed from 10 NIH BEST awardee institutions to address this concern, using time to degree and publication records as measures of efficiency and productivity. Comparing doctoral students who participated to those who did not, results revealed that across these diverse academic institutions, there were no differences in time to degree or manuscript output. Our findings support the policy that doctoral students should participate in career and professional development opportunities that are intended to prepare them for a variety of diverse and important careers in the workforce.
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Barnes, Taylor, Kirstin M. Burnett, W. Shawn Ramsey, and Kathrin Dunlap. "252 Better Preparing Animal Science Students for Education Associated Careers." Journal of Animal Science 98, Supplement_4 (November 3, 2020): 186. http://dx.doi.org/10.1093/jas/skaa278.343.
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Abstract An Animal Science degree prepares students for a broad range of career opportunities yet the two most discussed in the literature and assumed by society are in animal science industry or veterinary medicine. However, studies indicate that -60% of our students enter into education as a career path, yet animal science departments typically do not emphasize educational careers or provide opportunities for students to develop skills in methods relevant for animal science related teaching. To combat this lack of representation for educational career opportunities, our research university’s animal science department has acted in two ways:-Developed a laboratory teaching methods course that allows undergraduate students to serve as teaching assistants for an animal handling lab with support and supervision from the course and graduate student lab instructors-Performed a content analysis to identify the type, frequency, and way educational career paths are discussed and/or assessed in introductory animal science courses. These are the first steps in ensuring that students are as prepared for pursuit of a possible educational career at a level equal to that for industry or veterinary careers. Sustainability of animal science includes retaining students in educational careers and actively improving our educational practices within the discipline. These changes better prepare our undergraduate students to have more realistic job expectations and competence in teaching when they pursue graduate school or animal science related educational career options. The university animal science program also benefits, as the undergraduate teaching assistants improve the instructor-to-student ratio thus positively impacting safety and logistics of hands-on large animal labs while increasing one-on-one instruction time with students. These practices increase student engagement and learning. Additionally, the field of animal science will prosper from increased competence in pedagogical techniques providing a richer, more complete educational experience for our students both in and out of university settings.
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Metri, Lidya, and Afriwardi Afriwardi. "The Correlation Between the Degree of Pain with Estradiol Hormone Levels, Interleukin 1β (il-1β) Levels and Nitrite Oxide in Blood Serum of Endometriosis Patients." Revista de Chimie 73, no. 3 (July 29, 2022): 82–86. http://dx.doi.org/10.37358/rc.22.3.8537.
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Endometriosis is the chronic disease, in which the glandular and stromal-like endometrium grows outside the uterine cavity, Endometriosis is inflammatory and estrogen-dependent that affects 6-10% of women during their reproductive years and up to 50% of women receiving fertility treatment. The purpose of this study was to determine the correlation between the degree of pain with estradiol hormone levels, interleukin-1β (IL-1β) levels and Nitrite Oxide (NO) in the blood serum of patients with endometriosis. This type of research is an observational analytic with a cross sectional comparative study design in which the dependent and independent variables are obtained simultaneously. The research was conducted in type B and C hospitals. To take blood serum samples for endometriosis patients and the Biomedical Laboratory of FK Unand to check levels of estradiol hormone, levels of Interleukin-1β (IL-1β) and NO. The study was conducted in January - November 2020. The population was all patients who doing examination at the obstetrics gynecology department of the hospital. Samples were taken consecutively that met the inclusion and exclusion criteria with a total sample of 40 people. Data analysis using analyzed by univariate, bivariate and multivariate with chi-square test. The research results were obtained The mean age of endometriosis patients was 38.85 years, the mean pain degree of patients and the distribution of levels of estradiol, interleukin, 1β (IL-1β) and Nitric oxide. The results of the bivariate analysis showed that there were differences degree of pain with each Estradiol level, interleukin, 1β (IL-1β) as well as nitric oxide. The results of the multivariate analysis showed that there was a difference in the degree of pain with the three Estradiol levels. interleukin, 1β (IL-1β) and nitric oxide in the blood serum of people with endometriosis (P = 0,000 then p [α (0.05). From the research results it can be concluded that there are the relationship between degree of pain and level Estradiol, interleukin, 1β (IL-1β) and nitric oxide in the blood serum of people with endometriosis.
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Rozenfeld, Alejandro F., Sophie Arnaud-Haond, Emilio Hernández-García, Víctor M. Eguíluz, Manuel A. Matías, Ester Serrão, and Carlos M. Duarte. "Spectrum of genetic diversity and networks of clonal organisms." Journal of The Royal Society Interface 4, no. 17 (May 2007): 1093–102. http://dx.doi.org/10.1098/rsif.2007.0230.
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Clonal reproduction characterizes a wide range of species including clonal plants in terrestrial and aquatic ecosystems, and clonal microbes such as bacteria and parasitic protozoa, with a key role in human health and ecosystem processes. Clonal organisms present a particular challenge in population genetics because, in addition to the possible existence of replicates of the same genotype in a given sample, some of the hypotheses and concepts underlying classical population genetics models are irreconcilable with clonality. The genetic structure and diversity of clonal populations were examined using a combination of new tools to analyse microsatellite data in the marine angiosperm Posidonia oceanica . These tools were based on examination of the frequency distribution of the genetic distance among ramets, termed the spectrum of genetic diversity (GDS), and of networks built on the basis of pairwise genetic distances among genets. Clonal growth and outcrossing are apparently dominant processes, whereas selfing and somatic mutations appear to be marginal, and the contribution of immigration seems to play a small role in adding genetic diversity to populations. The properties and topology of networks based on genetic distances showed a ‘small-world’ topology, characterized by a high degree of connectivity among nodes, and a substantial amount of substructure, revealing organization in subfamilies of closely related individuals. The combination of GDS and network tools proposed here helped in dissecting the influence of various evolutionary processes in shaping the intra-population genetic structure of the clonal organism investigated; these therefore represent promising analytical tools in population genetics.
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Rose, Steven. "Précis of Lifelines: Biology, freedom, determinism." Behavioral and Brain Sciences 22, no. 5 (October 1999): 871–85. http://dx.doi.org/10.1017/s0140525x99002204.
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There are many ways of describing and explaining the properties of living systems; causal, functional, and reductive accounts are necessary but no one account has primacy. The history of biology as a discipline has given excessive authority to reductionism, which collapses higher level accounts, such as social or behavioural ones, into molecular ones. Such reductionism becomes crudely ideological when applied to the human condition, with its claims for genes “for” everything from sexual orientation to compulsive shopping. The current enthusiasm for genetics and ultra-Darwinist accounts, with their selfish-gene metaphors for living processes, misunderstand both the phenomena of development and the interactive role that DNA and the fluid genome play in the cellular orchestra. DNA is not a blueprint, and the four dimensions of life (three of space, one of time) cannot be read off from its one-dimensional strand. Both developmental and evolutionary processes are more than merely instructive or selective; the organism constructs itself, a process known as autopoiesis, through a lifeline trajectory. Because organisms are thermodynamically open systems, living processes are homeodynamic, not homeostatic. The self-organising membrane-bound and energy-utilising metabolic web of the cell must have evolved prior to so-called naked replicators. Evolution is constrained by physics, chemistry, and structure; not all change is powered by natural selection, and not all phenotypes are adaptive. Finally, therefore, living processes are radically indeterminate; like all other living organisms, but to an even greater degree, we make our own future, though in circumstances not of our own choosing.
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Bayer, Ilker S. "A Review of Sustained Drug Release Studies from Nanofiber Hydrogels." Biomedicines 9, no. 11 (November 4, 2021): 1612. http://dx.doi.org/10.3390/biomedicines9111612.
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Polymer nanofibers have exceptionally high surface area. This is advantageous compared to bulk polymeric structures, as nanofibrils increase the area over which materials can be transported into and out of a system, via diffusion and active transport. On the other hand, since hydrogels possess a degree of flexibility very similar to natural tissue, due to their significant water content, hydrogels made from natural or biodegradable macromolecular systems can even be injectable into the human body. Due to unique interactions with water, hydrogel transport properties can be easily modified and tailored. As a result, combining nanofibers with hydrogels would truly advance biomedical applications of hydrogels, particularly in the area of sustained drug delivery. In fact, certain nanofiber networks can be transformed into hydrogels directly without the need for a hydrogel enclosure. This review discusses recent advances in the fabrication and application of biomedical nanofiber hydrogels with a strong emphasis on drug release. Most of the drug release studies and recent advances have so far focused on self-gelling nanofiber systems made from peptides or other natural proteins loaded with cancer drugs. Secondly, polysaccharide nanofiber hydrogels are being investigated, and thirdly, electrospun biodegradable polymer networks embedded in polysaccharide-based hydrogels are becoming increasingly popular. This review shows that a major outcome from these works is that nanofiber hydrogels can maintain drug release rates exceeding a few days, even extending into months, which is an extremely difficult task to achieve without the nanofiber texture. This review also demonstrates that some publications still lack careful rheological studies on nanofiber hydrogels; however, rheological properties of hydrogels can influence cell function, mechano-transduction, and cellular interactions such as growth, migration, adhesion, proliferation, differentiation, and morphology. Nanofiber hydrogel rheology becomes even more critical for 3D or 4D printable systems that should maintain sustained drug delivery rates.
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Taha, Kamal, Ramana Davuluri, Paul Yoo, and Jesse Spencer. "Personizing the prediction of future susceptibility to a specific disease." PLOS ONE 16, no. 1 (January 6, 2021): e0243127. http://dx.doi.org/10.1371/journal.pone.0243127.
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A traceable biomarker is a member of a disease’s molecular pathway. A disease may be associated with several molecular pathways. Each different combination of these molecular pathways, to which detected traceable biomarkers belong, may serve as an indicative of the elicitation of the disease at a different time frame in the future. Based on this notion, we introduce a novel methodology for personalizing an individual’s degree of future susceptibility to a specific disease. We implemented the methodology in a working system called Susceptibility Degree to a Disease Predictor (SDDP). For a specific disease d, let S be the set of molecular pathways, to which traceable biomarkers detected from most patients of d belong. For the same disease d, let S′ be the set of molecular pathways, to which traceable biomarkers detected from a certain individual belong. SDDP is able to infer the subset S′′ ⊆{S-S′} of undetected molecular pathways for the individual. Thus, SDDP can infer undetected molecular pathways of a disease for an individual based on few molecular pathways detected from the individual. SDDP can also help in inferring the combination of molecular pathways in the set {S′+S′′}, whose traceable biomarkers collectively is an indicative of the disease. SDDP is composed of the following four components: information extractor, interrelationship between molecular pathways modeler, logic inferencer, and risk indicator. The information extractor takes advantage of the exponential increase of biomedical literature to automatically extract the common traceable biomarkers for a specific disease. The interrelationship between molecular pathways modeler models the hierarchical interrelationships between the molecular pathways of the traceable biomarkers. The logic inferencer transforms the hierarchical interrelationships between the molecular pathways into rule-based specifications. It employs the specification rules and the inference rules for predicate logic to infer as many as possible undetected molecular pathways of a disease for an individual. The risk indicator outputs a risk indicator value that reflects the individual’s degree of future susceptibility to the disease. We evaluated SDDP by comparing it experimentally with other methods. Results revealed marked improvement.
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Jurkiewicz, Karolina, Michał Kamiński, Wojciech Glajcar, Natalia Woźnica, Fanon Julienne, Piotr Bartczak, Jarosław Polański, Józef Lelątko, Maciej Zubko, and Andrzej Burian. "Paracrystalline structure of gold, silver, palladium and platinum nanoparticles." Journal of Applied Crystallography 51, no. 2 (March 12, 2018): 411–19. http://dx.doi.org/10.1107/s1600576718001723.
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Metallic nanoparticles are of great importance because of their unique physical, chemical, antimicrobial, diagnostic, therapeutic, biomedical, sensing, biosensing, catalytic and optical properties. Detailed knowledge of the atomic scale structure of these materials is essential for understanding their activities and for exploiting their potential. This paper reports structural studies of silica-supported silver, gold, palladium and platinum nanoparticles using X-ray diffraction and high-resolution transmission electron microscopy. Electron microscopy observation allowed the determination of nanoparticle sizes, which were estimated to be in the range of 45–470 Å, and their distribution. The obtained histograms exhibit a multimodal distribution of the investigated nanoparticle sizes. The X-ray diffraction data were analyzed using the Rietveld method in the form of Williamson–Hall plots, thePDFguifitting procedure and model-based simulation. The Williamson–Hall plots provide evidence for the presence of strain in all investigated samples. ThePDFguifitting results indicate that the investigated nanoparticles consist of atomic clusters with different sizes and degrees of disorder as well as slightly different lattice parameters. The detailed structural characterization performedviamodel-based simulations proves that all samples exhibit a face-centered cubic type structure with paracrystalline distortion. The degree of disorder predicted by the paracrystalline theory is correlated with the sizes of the nanoparticles. The catalytic properties of the investigated noble metals are discussed in relation to their disordered structure.
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Bremer, Martina, and R. W. Doerge. "The KM-Algorithm Identifies Regulated Genes in Time Series Expression Data." Advances in Bioinformatics 2009 (October 7, 2009): 1–10. http://dx.doi.org/10.1155/2009/284251.
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We present a statistical method to rank observed genes in gene expression time series experiments according to their degree of regulation in a biological process. The ranking may be used to focus on specific genes or to select meaningful subsets of genes from which gene regulatory networks can be built. Our approach is based on a state space model that incorporates hidden regulators of gene expression. Kalman (K) smoothing and maximum (M) likelihood estimation techniques are used to derive optimal estimates of the model parameters upon which a proposed regulation criterion is based. The statistical power of the proposed algorithm is investigated, and a real data set is analyzed for the purpose of identifying regulated genes in time dependent gene expression data. This statistical approach supports the concept that meaningful biological conclusions can be drawn from gene expression time series experiments by focusing on strong regulation rather than large expression values.
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BEHERA, U. K., C. M. YATES, E. KEBREAB, and J. FRANCE. "Farming systems methodology for efficient resource management at the farm level: a review from an Indian perspective." Journal of Agricultural Science 146, no. 5 (August 7, 2008): 493–505. http://dx.doi.org/10.1017/s0021859608007995.
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SUMMARYFarming systems research is a multi-disciplinary holistic approach to solve the problems of small farms. Small and marginal farmers are the core of the Indian rural economy constituting 0·80 of the total farming community but possessing only 0·36 of the total operational land. The declining trend of per capita land availability poses a serious challenge to the sustainability and profitability of farming. Under such conditions, it is appropriate to integrate land-based enterprises such as dairy, fishery, poultry, duckery, apiary, field and horticultural cropping within the farm, with the objective of generating adequate income and employment for these small and marginal farmers under a set of farm constraints and varying levels of resource availability and opportunity. The integration of different farm enterprises can be achieved with the help of a linear programming model. For the current review, integrated farming systems models were developed, by way of illustration, for the marginal, small, medium and large farms of eastern India using linear programming. Risk analyses were carried out for different levels of income and enterprise combinations. The fishery enterprise was shown to be less risk-prone whereas the crop enterprise involved greater risk. In general, the degree of risk increased with the increasing level of income. With increase in farm income and risk level, the resource use efficiency increased. Medium and large farms proved to be more profitable than small and marginal farms with higher level of resource use efficiency and return per Indian rupee (Rs) invested. Among the different enterprises of integrated farming systems, a chain of interaction and resource flow was observed. In order to make farming profitable and improve resource use efficiency at the farm level, the synergy among interacting components of farming systems should be exploited. In the process of technology generation, transfer and other developmental efforts at the farm level (contrary to the discipline and commodity-based approaches which have a tendency to be piecemeal and in isolation), it is desirable to place a whole-farm scenario before the farmers to enhance their farm income, thereby motivating them towards more efficient and sustainable farming.
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Cascajares, Mila, Alfredo Alcayde, Esther Salmerón-Manzano, and Francisco Manzano-Agugliaro. "Transfer of Agricultural and Biological Sciences Research to Patents: The Case of EU-27." Agronomy 11, no. 2 (January 29, 2021): 252. http://dx.doi.org/10.3390/agronomy11020252.
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Agriculture as an economic activity and agronomy as a science must provide food for a constantly growing population. Research in this field is therefore becoming increasingly essential. Much of the research is carried out in academic institutions and then developed in the private sector. Patents do not have to be issued through scientific institutions. Patents from scientific institutions are intended to have a certain economic return on the investment made in research when the patent is transferred to industry. A bibliometric analysis was carried out using the Scopus and SciVal databases. This study analyses all the research carried out in the field of agronomy and related sciences (Agricultural and Biological Sciences category of Scopus database) by EU-27 countries, which has been cited in at least one international patent. The data show that out of about 1 million published works only about 28,000 have been used as a source of patents. This study highlights the main countries and institutions in terms of this transfer. Among these, Germany, France and Spain stand out in absolute terms, but considering the degree of specialization. Regarding their specialization the institution ranking is led by Swedish University of Agricultural Sciences (58%), AgroParisTech (52%), Wageningen University & Research (48%), and INRAE (38%). It also analyses which journals used for this transfer are most important. For these publications more than 90% of the articles have had a higher-than-expected citation level for the year of publication, the type of publication and the discipline in which they are categorized. The most-obtained research fields can be distinguished as those related to genetics or mo-lecular biology, those related to specific foods, such as cheeses, milk, breads or oils, and, thirdly, the group covering food-related constituents such as caseins, probiotics, glutens, or starch.
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Tregellas, Jason R., Jason Smucny, Donald C. Rojas, and Kristina T. Legget. "Predicting academic career outcomes by predoctoral publication record." PeerJ 6 (October 4, 2018): e5707. http://dx.doi.org/10.7717/peerj.5707.
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Background For students entering a science PhD program, a tenure-track faculty research position is often perceived as the ideal long-term goal. A relatively small percentage of individuals ultimately achieve this goal, however, with the vast majority of PhD recipients ultimately finding employment in industry or government positions. Given the disparity between academic career ambitions and outcomes, it is useful to understand factors that may predict those outcomes. Toward this goal, the current study examined employment status of PhD graduates from biomedical sciences programs at the University of Colorado Anschutz Medical Campus (CU AMC) and related this to metrics of predoctoral publication records, as well as to other potentially important factors, such as sex and time-since-degree, to determine if these measures could predict career outcomes. Methods Demographic information (name, PhD program, graduation date, sex) of CU AMC biomedical sciences PhD graduates between 2000 and 2015 was obtained from University records. Career outcomes (academic faculty vs. non-faculty) and predoctoral publication records (number and impact factors of first-author and non-first-author publications) were obtained via publicly available information. Relationships between predoctoral publication record and career outcomes were investigated by (a) comparing faculty vs. non-faculty publication metrics, using t-tests, and (b) investigating the ability of predoctoral publication record, sex, and time-since-degree to predict career outcomes, using logistic regression. Results Significant faculty vs. non-faculty differences were observed in months since graduation (p < 0.001), first-author publication number (p = 0.001), average first-author impact factor (p = 0.006), and highest first-author impact factor (p = 0.004). With sex and months since graduation as predictors of career outcome, the logistic regression model was significant (p < 0.001), with both being male and having more months since graduation predicting career status. First-author related publication metrics (number of publications, average impact factor, highest impact factor) all significantly improved model fit (χ2 < 0.05 for all) and were all significant predictors of faculty status (p < 0.05 for all). Non-first-author publication metrics did not significantly improve model fit or predict faculty status. Discussion Results suggest that while sex and months since graduation also predict career outcomes, a strong predoctoral first-author publication record may increase likelihood of obtaining an academic faculty research position. Compared to non-faculty, individuals employed in faculty positions produced more predoctoral first-author publications, with these being in journals with higher impact factors. Furthermore, first-author publication record, sex, and months since graduation were significant predictors of faculty status.
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Mahendra, S. J., Viswanath Talasila, Abhilash G. Dutt, Mukund Balaji, and Abhishek C. Mouli. "A Functional Electrical Stimulator to Enable Grasping Through Wrist Flexion." International Journal of Biology and Biomedical Engineering 16 (January 3, 2022): 19–29. http://dx.doi.org/10.46300/91011.2022.16.4.
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Functional electrical stimulation is an assistive technique that utilizes electrical discharges to produce functional movements in patients suffering from neurological impairments. In this work, a biphasic, programmable current- controlled functional electrical stimulator system is designed to enable hand grasping facilitated by wrist flexion. The developed system utilizes an operational amplifier based current source and is supported by a user interface to adjust stimulation parameters. The device is integrated with an accelerometer to measure the degree of stimulated movement. The system is validated, firstly, on two passive electrical loads and subsequently on four healthy volunteers. The device is designed to deliver currents between 0-30mA, and the error between the measured current and simulated current for two loads were -0.967±0.676mA and -0.995±0.97mA. The angular data from the accelerometer provided information regarding variations in movement between the subjects. The architecture of the proposed system is such that it can, in principle, automatically adjust the parameters of simulation to induce the desired movement optimally by measuring a stimulated movement artifact (e.g., angular position) in real time.
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Medvedev, I. N., V. Yu Karpov, O. N. Makurina, M. V. Eremin, A. V. Dorontsev, F. R. Sibgatulina, and D. A. Ivanov. "Functional Reaction of the Cardiovascular System to Irritation of Vestibular Receptors in Students Engaged in Different Types of Martial Arts." International Journal of Biology and Biomedical Engineering 16 (January 3, 2022): 96–104. http://dx.doi.org/10.46300/91011.2022.16.12.
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Regular dosed physical activity in all cases has a tonic and healing effect on a person. Feasible muscle activity helps to improve the function of the heart, lungs, blood vessels and the nervous system. In martial arts, the reactivity of the vestibular apparatus is of great importance, providing the flow of information about the current position of the body in space, the success of movement in it and maintaining the stability of the posture due to the effective redistribution of muscle tone. Purpose of the work: to find out the dependence of the reaction of the cardiovascular system to the arising vestibular irritation in different types of martial arts. Martial arts classes help to increase the degree of vestibular stability. The statokinetic stability is very pronounced and increases in the course of hand-to-hand combat, which has a lot of moments with different severity of angular accelerations. The peculiarities of motor activity in any kind of martial arts inevitably affect the peculiarities of the reaction to the test with a change in the position of the head.
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Çamoğlu, Orhan, Tolga Can, and Ambuj K. Singh. "Accurate and Scalable Techniques for the Complex/Pathway Membership Problem in Protein Networks." Advances in Bioinformatics 2009 (February 23, 2009): 1–9. http://dx.doi.org/10.1155/2009/787128.
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A protein network shows physical interactions as well as functional associations. An important usage of such networks is to discover unknown members of partially known complexes and pathways. A number of methods exist for such analyses, and they can be divided into two main categories based on their treatment of highly connected proteins. In this paper, we show that methods that are not affected by the degree (number of linkages) of a protein give more accurate predictions for certain complexes and pathways. We propose a network flow-based technique to compute the association probability of a pair of proteins. We extend the proposed technique using hierarchical clustering in order to scale well with the size of proteome. We also show that top-k queries are not suitable for a large number of cases, and threshold queries are more meaningful in these cases. Network flow technique with clustering is able to optimize meaningful threshold queries and answer them with high efficiency compared to a similar method that uses Monte Carlo simulation.
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Martusevich, Andrew K., Konstantin A. Karuzin, Ivan V. Bocharin, and Alexandra V. Surovegina. "Monitoring the Effectiveness of Personalized Metabolic Correction in Athletes Using Biocrystallomics Techniques." International Journal of Biology and Biomedical Engineering 16 (January 21, 2022): 175–78. http://dx.doi.org/10.46300/91011.2022.16.23.
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The aim of this study was to estimate the effect of personalized metabolic support on the character of dehydration structuring of blood serum of qualified athletes. The study included 55 athletes with the category of cyclical sports. The random number test subjects were divided into 2 groups: the main group (n=23), where individualized metabolic correction was performed, and the comparison group (n=22), whose received placebo. Blood samples were obtained from athletes of both groups before the course and immediately after its completion. Then micro-preparations were prepared using the technology of classical crystalloscopy. Crystalloscopic facias were estimated with own system of visuamitric parameters. The study allowed us to establish that in qualified athletes, the course of taking biologically active agents, individualized on the basis of a multiparametric assessment of the state of oxidative metabolism of blood, contributed to the optimization of the crystallogenic properties of blood serum. This was manifested in the transformation of the structure of the main elements of the picture in the direction of reducing their size with a proportional increase in density, as well as in reducing the degree of destruction of crystals and expanding the marginal zone of the micropreparation.
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Srivastava, Sheenal, Yumi Patton, David W. Fisher, and Graham R. Wood. "Cotranslational Protein Folding and Terminus Hydrophobicity." Advances in Bioinformatics 2011 (June 6, 2011): 1–8. http://dx.doi.org/10.1155/2011/176813.
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Peptides fold on a time scale that is much smaller than the time required for synthesis, whence all proteins potentially fold cotranslationally to some degree (followed by additional folding events after release from the ribosome). In this paper, in three different ways, we find that cotranslational folding success is associated with higher hydrophobicity at the N-terminus than at the C-terminus. First, we fold simple HP models on a square lattice and observe that HP sequences that fold better cotranslationally than from a fully extended state exhibit a positive difference (N−C) in terminus hydrophobicity. Second, we examine real proteins using a previously established measure of potential cotranslationality known as ALR (Average Logarithmic Ratio of the extent of previous contacts) and again find a correlation with the difference in terminus hydrophobicity. Finally, we use the cotranslational protein structure prediction program SAINT and again find that such an approach to folding is more successful for proteins with higher N-terminus than C-terminus hydrophobicity. All results indicate that cotranslational folding is promoted in part by a hydrophobic start and a less hydrophobic finish to the sequence.
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Simons, G., E. Janssen, J. Veldwijk, R. Disantostefano, M. Englbrecht, C. Radawski, L. Valor, et al. "POS0591 TREATMENTS TO PREVENT RHEUMATOID ARTHRITIS IN FIRST DEGREE RELATIVES: DEMOGRAPHIC AND PSYCHOLOGICAL PREDICTORS OF RISK TOLERANCES." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 562.1–562. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1611.
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BackgroundThere is a growing research focus on the development of interventions to reduce risk of rheumatoid arthritis (RA) in at-risk groups.(1) RA patients’ first-degree relatives (FDRs) have an elevated risk of developing RA and are potential candidates for preventive interventions. Recent studies have quantified the preferences of at risk groups for preventive treatments.(2-4) Little is known about predictors of preference heterogeneity in this context.ObjectivesAssess the extent to which FDR characteristics and beliefs predict risk tolerances for preventive treatments.MethodsAdult FDRs of patients with confirmed RA in the UK were invited to take part in a web-based survey. FDRs enrolled in a UK prospective cohort (PREVeNT-RA) were also invited. Survey development, including attribute selection and presentation, was informed by qualitative research, ranking surveys, literature review, and expert opinion including patient research partners. Respondents received information about RA, questions to check comprehension, and an introduction to the survey. Participants were asked to imagine they were experiencing arthralgia and had positive autoantibody tests indicating a 60% chance of developing RA within two years. Using a probabilistic threshold technique, participants made choices between no treatment (no benefit and no risks) or a preventive treatment option. Treatment options were defined by a fixed level of benefit (reduction in risk of RA from 60% to 20%) and varying levels of risks (Table 1). For each treatment risk, participants made a series of choices where the risk was systematically increased or decreased until they switched their choice. This procedure was repeated for each of the remaining risks. Participants also completed items assessing demographics, perceived risk of developing RA, health literacy, subjective numeracy, the Brief Illness Perception Questionnaire (IPQ) and the Beliefs about Medicines Questionnaire General (BMQ-G). The maximum acceptable risk (MAR) respondents were willing to accept for a 40% (60% to 20%) point risk reduction in developing RA was summarized across participants using descriptive statistics. Associations between MARs and participants’ characteristics and illness/medication beliefs were assessed using interval regression. Independent variables were dichotomized and effects coded.Table 1.Attributes and levels of treatment optionsTreatment attributeLevels describing no treatment optionLevels describing treatment optionChance of developing RA60%20%Chance of mild side effects0%2%; 4%; 5%; 7% or 10%Chance of a serious infection due to treatment0%1%; 1.5%; 2%; 3% or 5%Chance of a serious side effect that is potentially irreversible0%0.001%; 0.01%; 0.02%; 0.05% or 0.1%Results289 FDRs (80 male) responded. The mean (SE) MAR for mild side effects, serious infection, and serious side effects was 29.08 (1.52), 9.09 (0.60) and 0.85 (0.27), respectively. Participants aged over 60 years were less tolerant of risk of serious infection than average (mean MAR - 2.06 (0.78)) and younger participants were more tolerant of risk of serious infection than average (mean MAR + 2.06 (0.78)). Risk of mild side effects was less acceptable to participants who perceived they were likely/very likely to develop RA (mean MAR - 3.34 (1.55)) than to those who did not (mean MAR + 3.34 (1.55)). Education level, health literacy, numeracy, IPQ and BMQ-G subscales were not predictors of risk tolerance.ConclusionAge and perceived risk of RA had a significant impact on FDRs’ tolerance for specific, but not all, included risks. Cognitive ability and beliefs about RA/medicine did not explain preference heterogeneity. This is informative for drug development and the development of tailored risk communication resources to support preventive approaches.References[1]Mankia et al. Ann Rheum Dis. 2021;80(10):1286-98.[2]Simons et al. Ann Rheum Dis. 2021;80:96-7.[3]Harrison et al. Plos One. 2009; 14(4): e0216075.[4]Finckh et al. Curr Rheumatol Rep. 2016;18: 51.AcknowledgementsOn behalf of the PREFER project. PREFER received funding from the IMI 2 Joint Undertaking (grant No. 115966), which receives support from the EU’s Horizon 2020 research and innovation program and European Federation of Pharmaceutical Industries and Associations (EFPIA). K. Raza is supported by the NIHR Birmingham Biomedical Research Centre.Disclosure of InterestsGwenda Simons: None declared, Ellen Janssen Shareholder of: Johnson & Johnson, Employee of: Janssen Research and Development, Jorien Veldwijk: None declared, Rachael DiSantostefano Shareholder of: Johnson & Johnson, Employee of: Janssen Research and Development, Matthias Englbrecht Speakers bureau: Abbvie, Chugai, Eli Lilly, Novartis, Roche, Sanofi, Mundipharma, Paid instructor for: Abbvie, Chugai, Roche, Consultant of: Abbvie, Novartis, Roche, Sanofi, Grant/research support from: Roche, Chugai, Christine Radawski Shareholder of: Eli Lilly, Employee of: Eli Lilly, Larissa Valor: None declared, Jenny Humphreys: None declared, Ian N. Bruce: None declared, Brett Hauber Shareholder of: Pfizer Inc., Employee of: Pfizer Inc., Karim Raza Consultant of: Abbvie, Sanofi, Grant/research support from: Bristol Myers Squibb, Marie Falahee: None declared.