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Wahlberg, Liljeström Karin. "Att följa decorum : rumsdispositionen i den stormaktstida högreståndsbostaden på landet /." Stockholm : Konstvetenskapliga institutionen, Stockholms universitet, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7145.
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Butler, Charles. "Spenser's allegorical decorum : analogical and exemplary allegory in 'The Faerie Queene'." Thesis, University of York, 1989. http://etheses.whiterose.ac.uk/10894/.
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Sampaio, Lilian Alves. "O riso e a náusea: a disputa simbólica encenada em um programa de televisão." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/8/8132/tde-21062013-105729/.
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A transmissão do Programa do Ratinho colocou em evidência uma antiga questão sobre a qualidade dos programas exibidos pela televisão brasileira, em que se traça uma distinção entre o que é de alto nível e o que é de baixo nível. A leitura dos artigos publicados na imprensa revela que o programa provoca um profundo mal-estar em determinados grupos, por outro lado, a etnografia do programa mostra que as rupturas, tanto das normas de conduta quanto das regras do gênero televisivo, são propositais e carregam uma dimensão cômica. É essa inter-relação entre o mal-estar e o riso que sugere o sentido das rupturas praticadas no programa. O diálogo indireto entre o conteúdo do programa e as críticas impressas nos jornais mostra a construção de uma identidade positiva em torno do ideal de autenticidade, que se opõe à imagem negativa, de degradação moral, veiculada pela imprensa. Nesse sentido, revela uma disputa simbólica que conjuga no mesmo movimento a distinção e a desqualificação do outro. O programa encena essa disputa, em que se define o que é desejável e o que é desprezível, o que dá dignidade e o que degrada o ser humano, simulando a inversão da escala de valores na qual aqueles que se incomodam são colocados como inferiores em relação ao apresentador e aqueles que apreciam o programa, os quais se apropriam das qualidades associadas à superioridade moral.The purpose of this essay is to analise the interconnections between the disgusting and the comic in Ratinho`s TV programme. This programme came up the old question about the quality of TV programmes in Brazil, where there is a clear distinction between the good level and the bad level. The reading of public papers shows that the programme causes a deep bad feeling in some groups of society. On the other hand, the programme´s ethnography shows that the breaking of behavior rules and TV rules is intentional and has a comic dimension. These interconnections between the disgusting and the comic are the aim of the breaking rules. The indirect comunication between the program content and the media`s critiques in the newspapers shows the construction of a positive identity of authenticity in contrast with the media´s negative image of moral degradation. Furthermore, it revels a symbolic war that causes the same movement of other´s distinction and desqualification. The programme is the scene of this war, in which one can define what is desirable and what is disgusting, what gives dignity and what gives degradation to human being. Ratinho´s programme simulates a inversion of moral rules, in which the one´s who criticize the programme are taken as inferiors to the one´s who like it, so, these can put themselves in a position of moral superiority.
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Fisher, David Lawrence. "Dulce et Decorum est| Moral Injury in the Poetry of Combat Veterans." Thesis, Pacifica Graduate Institute, 2019. http://pqdtopen.proquest.com/#viewpdf?dispub=13427381.
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Conventional studies of veterans’ longitudinal mental health approach the topic through the post-traumatic stress disorder (PTSD) lens. This qualitative study shifts the focus from a PTSD psychosomatic-centric approach to a psycho-spiritual examination of the sequela of war in the veteran psyche: this approach has been named in recent literature, moral injury. Utilizing a methodological approach situated in the philological region of hermeneutics, a Reductionist dialectic was selected. This study illustrates that the quotidian war poetry read by this researcher exhibits psycho-spiritual moral injury. The relevant emergent themes of the study include: (a) the function of memory, of not-forgetting, (b) the psychological torment of psychic dismemberment, (c) the acknowledgment of suffering in archetypal salt, and (d) the not-forgetting component of psychic re-memberment necessary for resolving moral injury. Reorienting the focus from PTSD to moral injury, this study finds critical implications to helping war veterans with their sequela of war. For instance, conventional treatments for PTSD such as prolonged exposure (PE) or cognitive behavior therapy (CBT), while effective for treating the co-morbid symptoms of PTSD, do not address the profound insights which can be gleaned from re-examination of the phenomena in terms of moral injury. Most importantly, moral injury as a psycho-spiritual dilemma is something for which the veteran must embrace primacy in seeking resolution, working outside of the typical evidenced-based therapies. This comports with the alchemists who cautioned: Only by working with intense focus on self-transformation can the lapis philosophorum be achieved.
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Jewell, Kaelin. "Architectural Decorum and Aristocratic Power in Late Antique Rome, Constantinople, and Ravenna." Diss., Temple University Libraries, 2018. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/526134.
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Art HistoryPh.D.
This dissertation explores in the ways in which decorum, or the appropriateness of form and behavior, served as an underlying principle in the patronage, design, and construction of monumental architecture, sculpture, and inscriptions by the aristocratic elite of late antique urban environments. Throughout the dissertation, I deliberately turn my attention away from imperial buildings like Emperor Justinian's (r. 527-565) Hagia Sophia and towards those projects financed by aristocrats and elites, with a focus placed upon those associated with the gens Anicii and their sphere. It is through the discussions of the built environments of Rome, Constantinople, and Ravenna in the fourth through sixth centuries CE, that my dissertation reveals the ways in which aristocrats and elites, like members of the gens Anicii and wealthy bankers like Julianus Argentarius, were able to concretize their power in periods of political change. Their employment of a decorum of architecture, based upon Vitruvian and Ciceronian ideals, demonstrates the central role these individuals played in the shaping of the visual culture of the late antique Mediterranean. It was through the patronage of statues and buildings that were thoughtfully dedicated, strategically located, and purposefully decorated that these wealthy patrons were able to galvanize their non-imperial authority. In historical moments wracked by war, plague, and political instability, the finance and construction of large-scale statuary on prominently inscribed plinths, as well as solid, immovable buildings afforded these elites with a sense of permanence and stability that, they hoped, would last in perpetuity.
Temple University--Theses
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Tini, Valéria. "A (in)discrição: aspectos do decoro em \'Dom Quixote\' de Miguel de Cervantes." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/8/8145/tde-27072007-114555/.
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Este trabalho tem o objetivo de verificar a presença do conceito de discrição em três capítulos da obra Don Quijote de la Mancha, de Miguel de Cervantes. Tais capítulos estão localizados na segunda parte da obra e se referem aos conselhos dados por Dom Quixote ao seu fiel escudeiro, Sancho Pança, antes que este assumisse seu governo na ilha Barataria. O conceito de discrição é bastante amplo e complexo. Fazem parte dele atitudes morais e sociais que visam a uma adequada atuação social do indivíduo no universo em que ele se encontra. O exercício da discrição requer o conhecimento de alguns elementos que funcionam como uma espécie de pré-requisito para a sua prática. Entre eles estão a prudência, o discernimento, a cultura e a erudição. Contribuem para a apreensão do conceito de discrição os tratados sobre comportamento social dos séculos XVI e XVII, sobre os quais teceremos comentários específicos, relacionando-os, sempre que possível, ao Quixote de Cervantes. Em nossas considerações, também verificaremos a maneira específica como Cervantes trabalha o conceito de discrição em sua narrativa. Por vezes, o autor subverte as regras do decoro literário, promovendo a quebra da rigidez do conceito, utilizando-o de uma maneira que demonstra variedade em sua aplicação.This dissertation aims at examining the presence of the concept of discretion in three chapters of Don Quijote de la Mancha by Miguel de Cervantes. Such chapters belong to the second part of mentioned book and they refer to the pieces of advice given by dom Quixote to Sancho Pança, before his faithful squire assumed the government of Barataria island. The concept of discretion is quite vast and complex. It includes moral and social attitudes wich provide for the individual\'s proper social behavior within the universe where he lives. In order to be put into practice, the exercise of discretion demands the knowledge of some elements that function as a kind of pré-requirements, such as prudence, discernment, education and erudition. Treatises on social behavior in the 16th and 17th centuries contribute to the understanding of the concept of discretion, and we are making specific comments on them in search, as far as posible, of their connections with Cervantes\'s Quixote. Along this study we are also examining the specific way Cervantes deals with the concept of discretion in his narrative. There are instances in which the writer subverts the rules of literary decorum causing a rupture in the rigidity of the concept by using it in such a way that demonstrates variety in its application.
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Harrison, Stuart, and stuart harrison@rmit edu au. "Designing Appropriately - Design projects to examine how contemporary civic buildings can be distinguishable in suburban and regional Australia." RMIT University. Architecture and Design, 2008. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080428.122307.
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This research investigates contemporary architecture's difficulty in distinguishing new civic buildings from commercial and other non-public building types. Historically, the desire to create a clear typological distinction for the civic has come and gone through periods of time and key practitioners. Through projects, the masters attempts to formulate strategies to speak of the civic in the contemporary condition. The research aims to consider architectural language and its use in the context of new public buildings to establish a sense of difference from dominant urban typologies, and be grounded within a contemporary reading of the civic. This project-based research features three principal resolved design projects - a Civic Centre in Mildura; Council Offices for the City of Hume, Broadmeadows; and a new 'civic school' in the Melbourne outer suburb of Mill Park. The design process undertaken for each project is subject to investigation of selected precedents, both contemporary and historical, and these are explored through an illustrated written chapter.
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Hunter, Mark C. ""--with the propriety and decorum which characterize the society of gentlemen" : the United States Naval Academy and its youth, 1845-1861 /." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0034/MQ47459.pdf.
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Chapman, Patricia Ann. "Two Laureates and a Whore Debate Decorum and Delight: Dryden, Shadwell, and Behn in a Decade of Comedy A-la-Mode." unrestricted, 2006. http://etd.gsu.edu/theses/available/etd-11202006-050335/.
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Thesis (M.A.)--Georgia State University, 2006.Title from title screen. Malinda Snow, committee chair; Tanya Caldwell, Paul Schmidt, committee members. Electronic text (81 p.) : digital, PDF file. Description based on contents viewed May 8, 2007. Includes bibliographical references (p. 79-81).
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Bastos, Rodrigo Almeida. "A maravilhosa fábrica de virtudes: o decoro na arquitetura religiosa de Vila Rica, Minas Gerais (1711-1822)." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/16/16133/tde-08092010-160646/.
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A tese é destinada a demonstrar que o decoro foi um preceito fundamental para a fábrica da arquitetura religiosa em Vila Rica, atual cidade de Ouro Preto, entre 1711 e 1822. É resultado de uma pesquisa mais abrangente, dedicada a compreender a fábrica artística na capitania de Minas Gerais a partir das doutrinas e preceitos exatamente contemporâneos à sua construção. Em detrimento, portanto, de categorias anacrônicas pós-iluministas e românticas, como evolução, progresso, originalidade etc., pretende-se reconstituir a história desses conjuntos arquitetônicos ao mesmo tempo em que se procura investigar e reconstituir também historicamente os preceitos do seu presente, como o decoro, a decência, a comodidade, a perfeição, a maravilha, a elegância, a discrição, o engenho, a agudeza, a sutileza, o asseio, a formosura etc. O exame das obras, das fontes documentais primárias e também dos tratados artísticos e teológicos vigentes no período evidencia uma aplicação habitual e generalizada desses preceitos, que importa muito compreender historicamente. À luz do decoro, essa reconstituição tem se mostrado extremamente profícua. Concernente a um regime mimético que caracterizava não apenas as artes ainda hoje reconhecidas pelo termo, mas todo o aparato teatral das práticas de representação correspondentes à razão de estado católica e à sociedade de corte, o decoro ocupava um papel central naquele tempo; em especial na invenção, disposição e ornamentação da arquitetura religiosa, onde se investiam os maiores esforços e cabedais. Representação permanente das virtudes cristãs, personagens e eventos das Sagradas Escrituras e do dogma católico, a fábrica da arquitetura era destinada não apenas a encenar decorosamente as matérias da fé, como também a conduzir virtuosamente o fiel na sua própria edificação cristã rumo à salvação. Foram analisados os seguintes templos: a Igreja Matriz de Nossa Senhora do Pilar e as Capelas das Ordens Terceiras de Nossa Senhora do Carmo e São Francisco de Assis.This thesis aims to demonstrate that decorum was a fundamental precept to the religious architecture fabric in Vila Rica, a town currently named Ouro Preto. It is the result of broader research based on precepts which are contemporary with the architectural complex studied. Instead of using anachronic post-enlightenment or post-romantic categories, such as evolution, progress, originality etc., we intend to reconstruct the history of these architectural complexes and at the same time investigate and reconstruct historically precepts of the time, such as decorum, decency, perfection, wonder, elegance, discretion, skill, wit, ingeniousness, subtlety, beauty etc. The examination of the architectural works and primary sources, as well as artistic and theological treaties in force at the time have shown a frequent and widespread employment of these precepts, which must be understood historically. In the light of decorum, such reconstruction has proved to be extremely fruitful. Decorum concerns not only a rhetorical-mimetic regime which characterizes what is currently referred to as art, but also the entire theatrical apparatus of representation practices which correspond to court society and to the Catholic raison dÉtat. At that historical period it had a central role in the invention, disposition and ornamentation of religious architecture and the greatest efforts and fortunes, both private and official. The fabric of architecture, which consisted of permanent representation of Christian virtues, characters and events of the Holly Bible and Catholic dogma, was meant to decorously portray matters of faith, as well as to guide the believer virtuously in his own path of Christian edification towards salvation. The following churches were studied: Igreja Matriz de Nossa Senhora do Pilar and Capelas das Ordens Terceiras do Monte do Carmo and São Francisco de Assis.
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Spoel, Philippa M. "Disciplinary and bodily decorum in eighteenth-century British elocution, a rhetorical study of works by Thomas Sheridan, John Walker, and Gilbert Austin." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq22240.pdf.
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D\'Acol, Mítia Ganade. "Decoro musical e esquemas galantes: um estudo de caso das seções de canto solo das Missas de Requiem de José Maurício Nunes Garcia e Marcos Portugal." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/27/27157/tde-23032017-153229/.
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Existe na musicologia luso-brasileira uma tese de que a música litúrgica composta para celebrações religiosas nas igrejas brasileiras e portuguesas apresenta uma grande interpenetração dos estilos teatral e eclesiástico. Tal fato é interpretado não só como uma necessidade de exibição simbólica do poder monárquico, mas também como um atraso musical por parte dos compositores luso-brasileiros, por não serem mais decorosos na escrita da música sacra. Desta forma, a questão do decoro vem sido revisitada por pesquisas recentes, que já enxergam não uma falta de decoro musical no ambiente litúrgico luso-brasileiro, mas sim uma interpretação errônea do contexto cultural na qual esta música está inserida. O objetivo geral deste trabalho é o de discutir o decoro musical lusófono a partir do estudo da tratadística setecentista dedicada à averiguação do três estilos musicais (teatral, de câmara e eclesiástico), e de um estudo de caso das partes de solo das missas de Requiem de José Maurício Nunes Garcia e Marcos Portugal. Neste estudo, utilizaremos a teoria dos esquemas musicais como forma de averiguação do discurso musical, da capacidade comunicacional dos compositores e, consequentemente, seu decoro.It exists in Luso-Brazilian musicology a thesis that the liturgical music composed for religious celebrations in Brazilian and Portuguese churches presents a great interpenetration of theatrical and ecclesiastical styles. This fact is interpreted not only as a need for symbolic display of monarchical power, but also as a \"musical backwardness\" of the Luso-Brazilian composers, for not being more decorous in writing sacred music. Thus, the question of decorum has been revisited by recent research, which denies the existence of a \"lack\" of musical decorum in the Luso-Brazilian liturgical settings, and sees the problem as a misinterpretation of the cultural context in which this music is inserted. The aim of this study is to discuss the Lusophone musical decorum from the study of eighteenth-century treatises dedicated to the investigation of the three musical styles (theater, chamber and church), and a case study of the solo parts in the Requiem Masses of José Maurício Nunes Garcia and Marcos Portugal. In this study, we use the theory of musical schema as a way of investigating the musical discourse, the communicative capacity of composers and consequently their decorum.
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Muller, Barbara. "Les métaphores dans les romances de William Shakespeare : 'Pericles', 'Cymbeline', 'The Winter’s Tale' et 'The Tempest' : des prescriptions rhétoriques à l’écriture dramatique." Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAC034.
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L’usage que fait Shakespeare des métaphores dans les romances (Pericles, Cymbeline, The Winter’s Tale et The Tempest) contrevient aux prescriptions des traités de rhétorique anglais du XVIe siècle quant à l’élaboration de cette « figure du transport ». Les métaphores dans les romances sont marquées par une forte promotion de l’hybridité, que ce soit celle de la figure elle-même ou celle que le trope induit. Les métaphores que les rhétoriciens auraient pu qualifier d’inconvenantes et de cherchées trop loin contribuent à enrichir le genre protéiforme des pièces et la palette des émotions suscitées chez le spectateur. Elles ont aussi pour fonction de produire des effets catoptriques, de construire des identités sociales et sexuelles fluctuantes et complexes et de créer une dialectique subtile entre le visuel de la scène et celui de l’œil intérieur. Dès lors, le déploiement des métaphores au-delà des règles érigées par les rhétoriciens permet au dramaturge de révéler au mieux la diaprure du monde et celle des êtresShakespeare’s use of metaphors in the romances (Pericles, Cymbeline, The Winter’s Tale and The Tempest) breaks the rules of decorum such as they were prescribed by sixteenth-century rhetoricians concerning the elaboration of this “figure of transport”. Metaphors in the romances tend to promote hybridity in a very powerful way. The figure, which relies on the art of grafting meanings, creates generic hybridity. Metaphors which may well have been deemed inappropriate and far-fetched by Renaissance rhetoricians are a means of strengthening the protean genre of these plays and producing an elaborate affective response in the audience. Moreover, they produce catoptric effects, build complex and fluctuating social and sexual identities and construct a dialectic relation that invites the spectator to approach the plays both with their physical and their inner eyes. Therefore, the development of metaphors beyond strict rhetorical rules enables the playwright to change perspectives and embrace a larger view of the world
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Rämgård, Östlund Stefan. "Två avböner & en revolt i syndarnas teater : En studie i apologia och kriskommunikation." Thesis, Uppsala universitet, Avdelningen för retorik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-172854.
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Soares, Alessandro de Oliveira. "Do processo de cassação de mandato parlamentar por quebra de decoro." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/2/2134/tde-15032013-083010/.
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A presente dissertação tem por objeto de estudo o instituto da cassação de mandato por quebra de decoro, conforme previsto no art. 55, II, da Constituição da República de 1988, que determina que perca o mandato o deputado ou senador cujo procedimento for declarado incompatível com o decoro parlamentar. Trata-se de um estudo no qual analisamos diversos aspectos jurídicos relevantes do instituto, entre esses podemos destacar a definição mínima do que podemos entender por comportamento ofensivo ao decoro parlamentar, a natureza jurídica dos processos de cassação, os limites do exercício dessa competência pelas Casas do Congresso Nacional, as regras específicas previstas nos regimentos internos, bem como os limites do controle exercido pelo Poder Judiciário. Muitas das análises elaboradas são polêmicas e de difícil solução e envolvem temas candentes, não só do ponto de vista jurídico, mas também político, já que a cassação de mandato por quebra de decoro diz respeito a uma forma de perda antecipada do mandato representativo, implicando num fenômeno que resvala em todo o sistema democrático.This dissertation is a study about the expel proceding a parliament member in case of offense to decorum according to art. 55 II of Republic Constitution of 1988, which states that lose the mandate the deputy or the senator who proceed in disorderly behavior with parliamentary decorum. We analyze various legal issues relevant to the institute, among these we can highlight the minimal definition of what we can call as an incompatible behavior with parliamentary decorum, the juridical nature of the legislative process of expulsion, limits for that jurisdiction by the Congress, the special rules of the Congress internal regulations and the limits of control exercised by the Judiciary. Many elaborated analysis are controversial and difficult to solve, involving political and legal questions, since the expel by an incompatible behavior with parliamentary decorum is a way to lose beforehand the representative mandate, implying a phenomenon that echoes in all the democratic system.
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Leon, Roberto Sebastian. "Accommodation, Decorum, and Disputatio: Matteo Ricci's The True Meaning of the Lord of Heaven as a Renaissance Humanist Disputation." BYU ScholarsArchive, 2017. https://scholarsarchive.byu.edu/etd/6610.
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Matteo Ricci's True Meaning of the Lord of Heaven (1603) has been studied extensively by scholars of the Jesuit China Mission, especially in terms of accommodation through means of Scholastic and Humanist arguments and translation choices. Few of these studies, however, discuss the genre of this work (disputation), nor consider this genre in relation to Renaissance rhetorical teachings and how this relationship informs Ricci's accommodative strategies. The purpose of this paper is to remedy this gap in early modern Jesuit scholarship. Through a review of the history of accommodations in disputations in the Aristotelian-Scholastic and Ciceronian-Humanist traditions, this paper claims that True Meaning is a Humanist disputation, not only because Ricci translated Christian terms into Chinese and draws references from classical sources, but also because this text follows strategies taught in the Humanist, but not the Scholastic curriculum. If True Meaning is a Humanist disputation, then Ricci's teachings should be reconsidered from the perspective of Renaissance rhetoric, which sheds further light on how Ricci's work fits into Renaissance culture and the transformation of the early modern disputation genre, as well as provides further explanation of the Western accommodation paradigm Ricci brought to China, which is prior to understanding how Ricci was transformed by China.
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Adams, Richard Yusuf. "Beyond the minaret : a space for the spirit, a place for the people : toward an integral design for a contemporary mosque via an embodied decorum or ethos." Thesis, Cardiff University, 2017. http://orca.cf.ac.uk/105108/.
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This work is intended primarily as an original contribution to knowledge in the field of architecture and subsequently as a useful text for architects and designers and grass roots Muslim community builders. Though written to serve in particular the Muslim communities who seek to establish socially dynamic places of work, and worship, the present study is intended to be of interest to those looking at approaches to build collectively and create a beneficial spaces and places of great architectural merit. Although the particular lived way or praxis that is served is Islam, which asserts unseen and seen realms and a life beyond this life, the present study is written from the human phenomenological perspective of being and dwelling in this world here and now, and addresses the cultural role of architecture today. Islam is equally concerned with the eternal now of the present moment. This open book exploration is enframed by a) the foil of a specific proposed mosque project and b) grounded in the history and living tradition of Islam, and c) the phenomenologically understood life patterns of those who would dwell in the mosque complex daily. Research is guided by a key thesis that the simplest and humblest edifice, the most basic mosque, is adorned by and serves an ethos, by human rhythms and behaviour that are contained by its walls, and walls that are the very ornamentation of that ethos. This ethos shall be known throughout the work as an embodied adab, or embodied ‘gathering of all good.’ This ethos describes both the best or desired intentions and actions of people and the architectural manifestation that appropriately responds to an architectural program to serve,shelter and sustain this intent. The methodology to explore the notion of an embodied adab is interpretive, and accepts the prejudices of the author as the only valid starting point, when asserting that architectural theory and practice is dialogical in nature, gathering to itself many inter-subjective and inter-objective realms in a hermeneutic cycle, which results in a reiterative design process. Personal intentionality and embodied experience therefore meet an interpretive reading of the Islamic Tradition to grasp the historicity of the mosque complex or imaret. Therefore it is important to state that research of the present work is grounded in over fifteen years of being a student of Islam and the integral practice of Sufism, studying and practising with a lineage that travels back from Spain through Morocco across North Africa to the source for Muslims that is the resting place and abode of the Prophet Muhammad in Madina al munawarra in modern Saudi Arabia. This immersive period has lead to an embodied understanding of Islam and Sufism and a deepening understanding of Islamic Architecture, and the need for the ethical role of architecture to be reappraised when contemplating mosque architecture, as either a historic subject or a live project. Prior to an independent and intensive study of Islam as an adult, was a gently Buddhist upbringing which philosophically prioritised not being contained by dogma or controlled by religious communities or spiritual leaders. Study of Pre-Islamic religious texts such the Upanishads and Buddhist sutras as well as various forms of Shamanism including the Bon Tradition of Tibet and the core lojong and tonglen practices of Buddhism have been investigated affirming the universal core message of most ethical ways of living, that of compassion and loving kindness. This is celebrated in the Islamic tradition by Muslims trusting that the Prophet Muhammad was quite literally sent by the Divine as rahma, a ‘mercy’ to existence. The author has studied Islamic belief, practice and spiritual excellence, or iman, islam, and ihsan, directly from traditional scholars from around the world, who together transcend any single ethnic or social identity. Some are direct descendants of the Prophet Muhammad, Peace and blessings be upon him and his family, and some are not of Arab descent. The priority of adab has come from a personal reflection on the value of life as a balance of vita activa et vita contemplativa, and is supported as a specific Islamic ethos by instruction from living masters and the great texts of Muslim scholars and mystics, commonly known as Sufis. All religious and philosophical studies have contributed to the notion of an ‘Ionian Enlightenment’ or the unity of knowledge, not as some simplistic single answer but as the value of interpretation and seeing realms of knowledge holistically and in relation to one another. This understanding mirrors the Muslim perspective that the Real, Allah, is One. Such a sentence is mystical poetics to some and reality to others. The subject of this PhD must negotiate both kinds of people, just as the proposed mosque complex must face the street on which anyone may walk. Poetically and ecologically our phenomenal earthly existence too is one, as observed by holistic and systems theories, living as we do as part of a single ecosphere. Despite being in danger of sounding rather lofty due to the nature of the subject itself, this declaration is a statement of intent and a personal acknowledgement, in the tradition of any phenomenologically hermeneutic methodology. The author’s interpretation is framed by the intent to see unity in multiplicity, the architectural paradox that is drawing order out of chaos, as much as to see each whole building as an interrelated sum of parts. Part of that intent is to convey to Muslim client builders, in more accessible works that will come from present research, the priority of a devotional ethos in the design of the dwelling that is a mosque complex; an ethos that may serve the community as a whole, in the context of any urban environment. For the Muslim this can be appreciated as both a spiritual and pragmatic imperative. This study and design process is a hermeneutic process of unfolding and interpretation by which the prayer becomes the means to reconfigure existing spaces, and a place for the practice of ethical halal business transactions can provide a successful urban node in the townscape. With clear justification, considering the current geo-political climate, the present work is polemical. Beyond the Minaret is an open exploration that gathers knowledges, in order to revive an understanding of adab as an embodied characteristic of a specifically Islamic ethos, and affirm the ethical role of architecture in general. The present work is concerned with how the Muslim worldview and the perspective of an embodied adab can inform our understanding of the mosque complex in the C21st. Despite the Arabic origin of the word itself, adab as the ethos that is the ‘gathering of all good’ transcends and includes any culture or language, if we but value the art of interpretation.
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Spathon, Daniel. "Dialektens retorik : En studie om dialekter som retorisk resurs." Thesis, Södertörns högskola, Institutionen för kultur och lärande, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-19657.
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This paper examines dialect as a rhetorical means of persuasion. A survey containing inquires about four different Swedish dialects have been handed out mainly in Södertörn University and Stockholm University, in order to research the values and connotations of theese dialects. The four chosen dialects are as following: Göteborgska, Stockholmska, Norrländska and Skånska. The results of the survey are processed and compiled to see which attitudes these values and connotations may indicate to each dialect. These attitudes and values are then discussed in correlation with five rhetorical theories: Attitude as a means of persuation, Ethos, Persona, Rhetorical Agency and Pierre Bourdieu’s theory of Field and Habitus. From this discussion, conclusions are drawn about whether dialect may be used as a means of persuasion. However, the values and attitudes presented from the survey represents only the survey participants, and cannot be regarded as a general opinion. Altough it is a small-scale survey, certain conclusions can be made. The author of this essay concludes that dialect may be used as a means of persuasion, based on the survey results and rhetorical theories presented above. Finally, a critical component for this rhetorical agent is the adjustment of the audience. Without knowing the audiences values and attitudes to the dialect, the outcome of the effect may be hard to predict.
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Ronan, Sean. "Netspeak som retoriskt verktyg : Skapar elementen inom netspeak mer påträngande problem än vad de löser?" Thesis, Södertörns högskola, Institutionen för kultur och lärande, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-19862.
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With inspiration from Bitzers situational analysis a phenomenografic method has been used, influenced by Brown & Levinsons´s theory of politeness, to find perceptions concerning constraints (in Bitzer´s sense in his model of the rhetorical situation) in Internet-based communication. Based on three qualitative interviews, this essay has found that the perceptions are closely linked to views of what constitutes formal and informal contexts, varying due to the gender or age of the informant. Netspeak is not considered appropriate, with some exceptions, in any formal situation. However, the perceptions regarding decorum in informal situations differ in nature, based mainly on what kinds of associations and connotations are produced by elements found in netspeak. Since perceptions regarding informal situations vary, there is a large risk of misunderstanding, which this essay aims to survey.
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Dehut, Julien. "Rhétorique et informatique : à la source des humanités numériques." Electronic Thesis or Diss., Normandie, 2023. http://www.theses.fr/2023NORMR084.
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Cette étude est consacrée aux liens entre l'informatique et la rhétorique, et plus particulièrement à la manière dont nous interagissons avec les interfaces. À cette fin, nous avons mobilisé une partie du corpus rhétorique antique que nous avons essayé de faire dialoguer avec certains écrits contemporains sur la question de l'interaction avec les interfaces informatiques. Nous avons ainsi d'abord interrogé la notion de rhétorique elle-même pour savoir s'il était envisageable de l'appliquer à l'informatique. Une fois ce cadre déterminé, nous avons cherché avec Cicéron, mais plus encore avec Aristote en quoi la perspective antique pouvait nous permettre de mettre en évidence certains mécanismes qui sont en jeu lors de notre utilisation des ordinateurs. Nous avons ainsi examiné le rôle du _decorum_, mais aussi de l'enthymème et de la métaphore. Chacune de ces notions que nous avons tenté d'approcher au plus près de la pensée de leurs auteurs nous permet d'éclairer la manière dont les utilisateurs comprennent quoi faire avec les interfaces des ordinateurs. Cette perspective nous permet également de mettre en évidence la présence de mécanismes implicites en leur sein, mais aussi certaines limites et même d'expliquer un certain nombre d'échecs à partir d'exemples. Une interface qui s'apparente à un traitement de texte a été ainsi réalisée dans le cadre de cette étude. Celle-ci permet notamment de produire des documents complexes indépendamment du format des fichiers. Il s'agit pour nous de valider un certain nombre de nos hypothèses et de proposer une application à notre démarcheThis study is dedicated to the links between computing and rhetoric, and more particularly to the way we interact with interfaces. To this end, we have mobilized a part of the ancient rhetoric's corpus which we have tried to create a discussion with some contemporary writing on this issue. We first questioned the notion of rhetoric itself to see if it was possible to apply it to computer science. Once a framework was determined, we looked with Cicero, but even more with Aristotle to apprehend in what the ancient perspective could allow us to highlight some mechanisms that are at stake when using computers. We examined the role of the _decorum_, but also of the enthymeme and metaphor. We have tried to approach each of these notions as closely as possible to the thinking of their authors in order to allow us to shed light on how users understand what to do with computer interfaces. This perspective also allows us to highlight implicit mechanism, but also limitations and even failures from a number of examples. An interface similar to a word processor has been created in this study. This makes it possible to produce complex documents independently of the file format. It is for us to validate a number of our hypotheses and to propose an application to our approach
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Almeida, Renato Ribeiro de. "Mandato político na origem das inelegibilidades." Universidade Presbiteriana Mackenzie, 2014. http://tede.mackenzie.br/jspui/handle/tede/1139.
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Previous issue date: 2014-02-10Universidade de São Paulo
This master dissertation aims to systematize and provide discussions on the chances of acquiring ineligibility that follow bad representatives, especially after the introduction or modification of conducts arranged in Complementary Law No. 135/2010, popularly titled lei da ficha limpa amending the Supplementary Law No. 64/1990. It aims to systematize, in a single text, all the situations covered by the new legislation restricting the eligibility of those who are already in the exercise of political elective office, discussing what are the main legal nuances that, while restricting eligibility, concern, in general, the whole Brazilian society. Besides the specific subject of great legal significance which concerns the hypotheses about the acquisition of ineligibility during the period of elective office, this work will hold a debate about the principle of good governance and how it has been dealed by the international doctrine. This principle postulated in the Federal Constitution in Article 37, but also found throughout the constitutional text, argues that public managers, especially those agents with electoral and political mandate, with special emphasis on those dealing with public funds, have, as a functional duty, the obligation of providing proper accountability and transparency in their political- administrative acts featuring what can be named positive provisions of the State.
A presente dissertação de mestrado tem por objetivo sistematizar e estabelecer discussões sobre as hipóteses de aquisição de inelegibilidade a que estão sujeitos os maus mandatários de cargos eletivos, sobretudo após a introdução ou alteração de condutas dispostas na Lei Complementar n° 135/2010, popularmente intitulada Lei da Ficha Limpa, que alterou a Lei Complementar nº 64/1990. Objetiva-se sistematizar, em um único texto, todas as situações previstas pela nova legislação que restrinjam a elegibilidade daqueles que já se encontram no exercício de mandato político-eletivo, discutindo quais são as principais nuances jurídicas que, ao restringir a elegibilidade, atingem, de forma geral, toda a sociedade brasileira. Além da temática específica e de grande relevância jurídica sobre hipóteses de aquisição de inelegibilidade no exercício de mandato eletivo, este trabalho terá como pano de fundo o debate acerca do princípio da boa governança ou good governance, como é tratado pela doutrina internacional. Tal princípio, postulado na Constituição Federal principalmente no artigo 37, mas encontrado também ao longo de todo texto constitucional, dispõe que os gestores públicos, sobretudo os agentes com mandato político-eleitoral, com especial ênfase naqueles que lidam com recursos públicos, possuem, como dever funcional, a devida prestação de contas e a transparência em seus atos político-administrativos, caracterizando, desta forma, o que se pode chamar de uma prestação positiva do Estado.
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Peixoto, Nelson Brissac. "Decors en ruines." Paris 1, 1988. http://www.theses.fr/1988PA010622.
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Il s'agit d'un essai, au travers d'oeuvres de la litterature et du cinema contemporains, sur la derive d'individus perdus dans un monde simule et imagetique. Le detective prive, le cowboy, le voyageur, l'etranger, rues obscures, deserts, lieux de bord de route et villes abandonnees : des personnages et decors qui, repris par le cinema et inscrits dans l'architecture urbaine, faconnent l'experience et la sensibilite contemporaines. Cette etude cherche a montrer comment le mouvement incessant des protagonistes dessine differentes phases de constitution de notre imagerie. La ville apparait ici comme decor, etant donne le caractere cinetique et iconographique de son architecture. Mais l'artificialite croissante de ce monde s'accompagne de la decadence immediate de tout ce qui est reste en arriere, depasse par le mouvement : ces decors brillants et colores se dressent au milieu de ruines.
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Mazé, Christelle. "Les marqueurs sociaux : représentation, identité, statut en Égypte ancienne : (IIIe millénaire – mi IIe millénaire avant notre ère)." Thesis, Lyon 2, 2010. http://www.theses.fr/2010LYO20102.
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Ces recherches mettent en évidence comment les anciens Égyptiens rendaient visibles leur position sociale d’une part dans la hiérarchie des rapports entre individus et d’autre part au sein de leur groupe d’appartenance. Les marqueurs sociaux considérés sont de nature matérielle mais aussi culturelle et peuvent prendre la forme concrète d’objets de luxe et de prestige ou l’aspect plus subjectif de manières de s’exprimer ou de se comporter en faisant appel à la culture développée par les élites. Il ne s’agit pas ici d’établir un catalogue exhaustif mais de montrer comment les individus, en fonction de leur appartenance à des catégories sociales différentes, utilisent et interprètent les marques d’identité, de pouvoir et de prestige créées et perpétuées par la royauté et par les élites placées à son service. En fonction de l’importance sociale des individus, de l’époque considérée et de la capacité du pouvoir central à s’affirmer comme source de légitimité, les comportements ne sont pas les mêmes et les valeurs dont sont porteurs certains objets, certaines manières ont changé en même tant que la société évoluait. L’importance matérielle et symbolique de certains marqueurs sociaux a en effet pu être remise en cause ou au contraire développée par l’intégration de références à de nouvelles sources de pouvoir, tels les ancêtres ou les gouverneurs locaux sous la Première Période intermédiaire. En ce sens, le mimétisme culturel permet d’observer comment des personnes situées en dehors des sphères institutionnelles de l’État parviennent malgré tout à s’approprier le discours officiel imposé par le pouvoir central. L’étude s’organise en trois temps : la place de l’héritage lignager dans l’affirmation de la position sociale ; la manière de se comporter et d’occuper l’espace, tant dans la topographie que lors de manifestations cérémonielles ; l’usage des objets comme témoins de l’appartenance sociale et moyens d’expression du statut et de l’identité via la culture matérielleThis research highlights how Ancient Egyptians displayed their social position, on the one hand according to the hierarchical relationships between individuals, and on the other hand according to their membership of different groups. Social markers are of both material as well as cultural kinds and can take concrete forms like objects of luxury and prestige, but also as subjective forms, like ways of expressing oneself and behaving through references to a culture developed by the elite. It is not a matter of presenting a complete catalogue here. The intellectual process consists of making understand how individuals, ddepending on their membership of different social classes, used and interpreted marks of identity, power and prestige, which had been created and sustained by the royalty and the elite at their service. Depending on the social importance of individuals, the considered time period, and the ability of the central government to assert itself as a source of legitimacy, personal and collective behaviours were not always the same, and values embodied in objects and manners have changed, as society has evolved. The material and symbolic significance of social markers could have been thrown into question during leadership crisis or on the contrary, it could have been developed by the adoption of references to new sources of power, such as ancestors and local governors during the First Intermediate Period. In this way, cultural imitation allows us to observe how persons who are not linked to the institutional spheres of the State manage to take up the official discourse imposed by the central government after all. This study is divided into three parts: the significance of lineage to assert a social position; the way ones behaves and occupies the space around, in topography or in ceremonial events; the use of objects as signs of social membership et means to express status and identity through material culture
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Sanches, Juliane Cristina Trevisan. "Estudo ultraestrutural e imunohistoquímico do estroma uterino durante a gestação de camundongos deficientes em decorim." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/42/42134/tde-09062009-103722/.
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No presente estudo realizamos uma análise ultraestrutural e imuhistoquímica da organização das fibrilas de colágeno no endométrio durante a gestação de camundongos silvestres e deficientes em decorim. Os resultados mostraram que as fibrilas de colágeno em ambos os genótipos sofrem grande variação de forma e tamanho. Observou-se variação significante, na percentagem de distribuição dos diâmetros das fibrilas de colágeno existentes na região decidualizada em ambos os genótipos, porém foi maior nos animais Dcn-/-. Estes animais também apresentam maior percentagem de fibrilas finas quando comparados aos animais Dcn+/+. Observamos ainda que biglicam é expresso no endométrio não decidualizado dos animais Dcn-/-, no 3º dia de gestação. A expressão de lumicam mostrou-se nítida no estroma decidualizado e não decidualizado nos animais Dcn-/- no 7º dia de gestação e foi ausente nos animais Dcn-/-. Estes resultados mostraram que a ausência do decorim promove distúrbios no processo de agregação lateral das fibrilas espessas de colágeno.The present study is an ultrastructural investigation into the organization of collagen fibrils in the pregnant endometrium of wild-type and decorin-deficient mice. Our results showed that collagen fibrils from both genotypes present a great variability of shape and size in cross section. Significant variation in the diameter of collagen fibrils exists in the decidualized endometrium from both groups of animals. In the decidualized endometrium, the diameter of collagen fibrils increases in both genotypes were higher in Dcn-/- than in Dcn+/+ animals. In the Dcn-/- animals the percentage of thin fibrils with diameter is also higher, when compared with Dcn+/+ animals. We also showed that Bgn is expressed in the non decidualized endometrium in the Dcn-/- animals, on day 3 of pregnancy. The expression of lumican showed a very sharp labeling in the decidualized stroma from day 7, and in the non decidualized estroma from Dcn-/- animals. These results suggest that the deficience of decorin may play a role on collagen fibrillogenesis in different stages of pregnancy.
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LIENHARD, LABAUNE CATHERINE. "Complications neurologiques au decours des transplantations hepatiques." Nice, 1993. http://www.theses.fr/1993NICE6574.
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Tucker, Hannah L. "Extracellular Proteoglycan Decorin in Bovine Mammary Physiology." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/79430.
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The majority of bovine mammary gland research focuses on the main cell types - mammary epithelial cells and fibroblasts. However, the extracellular matrix (ECM) within the mammary gland is also of importance for its ability to regulate cell shape, proliferation, polarity, differentiation, gene transcription, protein synthesis, and secretion. Decorin is an ECM proteoglycan known to impact mammary cell proliferation in humans and rodents. Prior to this work, very little was known about decorin in bovine mammary biology. A series of bovine mammary cell culture experiments was conducted. The first experiment demonstrated existence of decorin pathway molecules in immortalized bovine mammary cells, but stopped short of demonstrating mature decorin proteoglycan deposition into the extracellular space. During the investigation it was noted that when cultured under basal conditions, intracellular decorin core protein (DCP) localization patterns appeared to be coordinated with specific phases of the cell cycle. Therefore, the objective of the second set of experiments was to characterize DCP localization patterns in bovine mammary epithelial cells (BME) at known phases of the cell cycle. The work was carried out in two sequential experiments. The hypothesis of the first experiment was that DCP accumulates in BME during S-phase of the cell cycle; the research rejected this hypothesis. The hypothesis of the second experiment, formulated after completion of the first experiment for this objective, was that DCP accumulates in BME during metaphase of the cell cycle. However, the experiment was unable to confirm of reject this hypothesis. Major findings were that both BME and mammary fibroblasts produce DCP and known decorin pathway molecules. BME produce intracellular DCP, but it is not accumulated during the S-phase of the cell cycle. However, it is still unknown if DCP is accumulated in BME during metaphase. Future research should focus on further characterization of decorin and its associated pathway molecules to learn if decorin induces proliferation or apoptosis of bovine mammary epithelial cells. This is important because number and activity of mammary epithelial cells ultimately determine milk yield in dairy cows. Fundamental knowledge gained in this research area may one day be applied at the animal-level and lead to gains in milk production efficiency by altering the cellular composition of mammary glands.Ph. D.
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HOFFMAN-GLEMANE, HEDOUIN SABINE. "Hemochromatose idiopathique diagnostiquee au decours d'une yersiniose." Amiens, 1989. http://www.theses.fr/1989AMIEM021.
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Deniot, Joëlle. "Le decor ouvrier." Nantes, 1987. http://www.theses.fr/1987NANT3015.
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Cette recherche s'interesse aux logements de 70 familles de nantes et de la region de l'ouest. A travers une demarche ethno-sociologique utilisant photographies et interviews, l'etude elabore la notion de systemes decoratifs populaires. Gout pour les bibelots anthropomorphes, zoomorphes, censure des miroirs, afflux des motifs aux murs, photos d'auto-symbolisation familiale constituent les elements les mieux partages par l'ensemble des familles. Amenagements a l'ecart des logiques de la distinction avec leurs traces esthetiques du metier dans les objets auto-produits, avec leurs decors qui exhibent bien mieux le plaisir des liens noues au sein des proches que le prestige des biens marchands. Mais le plaisir des abondances baroques, des chromatismes brillants s'equilibre desormais avec de nouveaux apprentissages : disposition plus aeree des objets aux murs, sur les meubles, recherche d'effets colores moins soutenus, conversion aux valeurs du meuble artisanal hors serie, aux valeurs de l'objet ancien. Ce nouveau langage d'harmonies plus disciplinees, plus conscientes d'elles-memes, apparait notamment dans les menages en position sociale haute dans le milieu; la ou le mari est ouvrier qualifie, la femme salariee dans des emplois de bureau, les professions de coiffeuse ou de couturiereThis thesis is founded on the study of 70 workingclass households in nantes and the area around the city. It straddles the boundary between ethnology and sociology. It uses photographs and the result of many interviews conducted at intervals over a period of 6 years to develop and support the idea that there exists an elaborate discernable system of interior decoration in the homes of working families. A taste for curios figures of people and animals, the frequent use of motifs on walls, the ways in which photographs of members of the family are used and a general absence of mirrors constitute a pattern. There are differences which derive from the calling or trade of individuals, verying skills in handicraft, the values inherited from parents or adopted from neighbours and the accident of gifts which are often esteemed for themselves rather their beauty or value. The taste for brighshowy colours and elaborate ornamentation is changing in favour of a more restrained use of objects on walls and furniture, a search for softer colour combinations and a greater value attached to individuality and to the antique. The new taste for harmony and order and a more deliberate approach to decoration appears with greatest strength in households which verge on the middle class : for example where the husband is a skilled worker and the wife earns a salary from office work or is a hairdresser or couturiere
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Didraga, Mihaela Alina. "Analytical approaches towards structural characterization of human lung decorin a comparative study of decorin from control and emphysematous lungs /." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2008. http://irs.ub.rug.nl/ppn/.
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Fust, Anita. "Lung mechanics in mice : effect of decorin deficiency." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80268.
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Decorin is required for the normal fibrillogenesis and spatial arrangement of collagen. As collagen is important in determining the elastic behaviour of the lung, we hypothesized that lung tissue mechanics would be altered in decorin deficient (Dcn-/-) mice. Complex impedance, pressure-volume curves, and length-stress curves of lung parenchyma were measured in C57BL/6 mice, 6 Dcn-/- and 6 wildtype ( Dcn+/+), both in vivo and in vitro. Immunohistochemistry and Western blotting were performed to identify decorin and biglycan in the lung tissues. In vivo, airway resistance was decreased and lung compliance was increased in Dcn-/- mice. In vitro, length-stress curves showed increased compliance in the Dcn-/- mice. Immunohistochemistry showed decorin staining in the airway and vessel walls of Dcn+/+ but not Dcn-/- mice; Western blots showed that biglycan levels were not different in the Dcn-/- mice. These data support a critical role for decorin in the formation of the lung collagen network. Lack of decorin alters lung tissue mechanical behaviour. Additionally, the data from Dcn+/+ mice were compared to those from other species, and is consistent with the evidence in the literature that mouse lungs differ structurally from other species. Finally, differences observed in vivo vs. in vitro suggest that measurements made in the strip more accurately reflect lung tissue properties.
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Devlin, Steve. "Practical Decom List Switching." International Foundation for Telemetering, 1988. http://hdl.handle.net/10150/615238.
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International Telemetering Conference Proceedings / October 17-20, 1988 / Riviera Hotel, Las Vegas, NevadaWith more complex vehicle designs, the frequency and number of measurements contained in telemetry data streams has dramatically increased. One way of improving the use of bandwidth is to change the sample rate, quantity, or type of measurements dynamically. A telemetry front end must be programmable to handle different formats. In a front end that decommutates and routes measurements, a decom list is a control program, which defines the location, size, orientation, and identity of the measurements. To deal with dynamic format changes, a telemetry front end must be able to switch between decom lists. A practical approach to decom list switching must address the needs of error avoidance, packet switching, and the location of switching keys in any portion of the format. Switching between formats should not be restricted to a preprogrammed sequence, but should allow multiple destinations from a particular decom list. A practical and flexible implementation of decom list switching is detailed along with an explanation of how this implementation solves a variety of decommutation problems.
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Marchica, Cinzia Loreta 1984. "Allergen-induced asthma is decreased in decorin-deficient mice." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116096.
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Decorin, is an extracellular matrix proteoglycan with important biological functions. Decorin deficiency affects collagen fibrillogenesis, airway mechanics, airway-parenchymal interdependence, and airway smooth muscle proliferation and apoptosis. We questioned whether decorin deficiency would alter allergen-induced asthma in a mouse model. Decorin-/- and decorin+/+ mice (C57Bl/6) were sensitized and challenged with ovalbumin. Control animals received saline. Responsiveness was assessed at baseline and after delivery of increasing concentrations of methacholine. Histological analyses were also performed. Decorin deficiency resulted in more modest hyperresponsiveness. Respiratory resistance and elastance along with tissue damping and tissue elastance, were increased in ovalbumin decorin +/+ and decorin-/-, but more so in decorin+/+ . Airway resistance was increased in ovalbumin decorin+/+ only. Inflammation and collagen staining within the airway wall, were increased in ovalbumin decorin+/+ mice only; whereas biglycan was significantly increased in ovalbumin decorin-/- mice only. These results reflect the role of decorin in the development of allergen-induced asthma.
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Fiedler, Lorna. "Role of decorin in control of endothelial cell behaviour." Thesis, Cardiff University, 2007. http://orca.cf.ac.uk/55666/.
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Angiogenesis is a complex process regulated by co-ordination of extracellular matrix (ECM) and growth factor signalling (via integrins and growth factor receptors respectively). Dysregulated angiogenesis contributes to disease pathology and progression, while an adequate blood supply is crucial for successful tissue repair and reconstruction. Thus an understanding of the mechanisms by which ECM controls angiogenesis would contribute to development of therapeutic strategies. Decorin is a small leucine-rich repeat proteoglycan consisting of a core protein and a single glycosaminoglycan. Decorin has been reported to contribute to ECM organisation through interaction with numerous ECM components, including collagen types I, VI, XII and XIV, fibronectin, thrombospondin, tropoelastin and tenascin-X. Further, decorin influences growth factor activity, interacts with a2pl integrin, and can activate growth factor receptors. In the absence of decorin, angiogenesis is dysregulated however it is not known which of these interactions are responsible. This thesis investigates the role of decorin interactions with collagen type I, a2pl integrin (a collagen I receptor), and the IGF-I receptor in modulating endothelial cell behaviour. This thesis demonstrates that both collagen-bound and soluble decorin enhance endothelial cell adhesion and migration, and that the latter may involve activation of the IGF-I receptor, and the small GTPase Rac, by decorin. In accordance with this, decorin induced morphological changes consistent with activation of small GTPases. Further, decorin interacts with a2pl integrin via the GAG moiety, and may influence integrin activity in an allosteric manner, although the intact proteoglycan is required for modulation of endothelial cell behaviour. It was also demonstrated that decorin supports a2pl integrin activation in the presence of the specific inhibitor rhodocetin. Additionally, decorin activates transcription factors associated with long-term cell survival and quiescence. Together, these data implicate decorin as an important regulator of several aspects of angiogenesis pertinent to establishment of mature neo-vessels.
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Vieira, Sofia Daniela Peixoto. "Decorar a minha escola: tecnologias informáticas e padrões geométricos." Master's thesis, Universidade de Aveiro, 2010. http://hdl.handle.net/10773/3554.
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Mestrado em Multimédia em EducaçãoO contacto com as tecnologias informáticas começa desde tenra idade quando os brinquedos se tornam cada vez mais tecnológicos e passam a ser parte integrante da vida das crianças. A escola tem, por isso, o dever de integrar as tecnologias nas suas práticas logo nos primeiros anos escolares permitindo, assim, o desenvolvimento de competências essenciais nesta e outras áreas, tanto mais que essa integração beneficia o processo de ensino e de aprendizagem. As tecnologias podem funcionar como forte aliado na construção do conhecimento. Não obstante a sua importância, a Matemática é vista muitas vezes como enfadonha, difícil e totalmente desenquadrada da realidade. Experiências de aprendizagem com padrões geométricos, nomeadamente frisos, poderão constituir uma forma de incentivar à mudança deste preconceito negativo acerca da Matemática ao mesmo tempo que contribuem para o desenvolvimento da competência Matemática em geral e da geometria em particular. Nesta área, outra problemática presente nos primeiros anos de escolaridade é o escasso desenvolvimento de projectos e o trabalho entre pares, talvez por se achar que a pouca autonomia e capacidade de trabalho das crianças é um impedimento para a implementação destas práticas na sala de aula. Neste seguimento, com a investigação desenvolvida pretendeu-se avaliar o impacto do uso das tecnologias informáticas no 1º ano do 1º Ciclo do Ensino Básico, como suporte de uma abordagem centrada nos padrões matemáticos, num ambiente de trabalho de projecto, no desenvolvimento de competências matemáticas e tecnológicas. Atendendo aos objectivos que se perseguiam, optou-se por um estudo de caso múltiplo, essencialmente qualitativo, que se desenvolveu num contexto de investigação-acção, numa turma do 1º ano de uma escola do 1º Ciclo do Ensino Básico. As principais técnicas e instrumentos de recolha de dados consistiram na observação, directa e participante, apoiada por registo em vídeo e fotográfico e por um diário de bordo, onde foram anotados comentários, comportamentos e reacções das crianças, e na análise documental das produções dos alunos. No início do estudo foi também utilizado o inquérito por questionário com o objectivo de averiguar os conhecimentos prévios dos alunos a nível tecnológico. A análise dos dados, descritiva e interpretativa, foi apoiada em transcrições, digitalizações e fotografias representativas. Os dados de natureza quantitativa foram tratados por recurso ao programa Excel e apresentados em quadros. A investigação desenvolvida permite concluir que um trabalho de projecto desenvolvido com alunos de baixa faixa etária que concilie as tecnologias informáticas e a Matemática, mais concretamente padrões geométricos, contribui efectivamente para o desenvolvimento de competências matemáticas e tecnológicas.
Despite its importance, mathematics is often seen as boring, difficult and totally out of reality. From the very beginning, learning experiences with geometric patterns, namely strips, supported by informatics tools, can be a way to encourage a change on that negative preconception about mathematics at same time that contributes to the development of mathematics skills in general and of geometry in particular. On the other hand, in earliest years of schooling, there are insufficient development of projects and teamwork, maybe due to the believe that the limited autonomy and work capacity of children is an obstacle to the implementation of these practices in the classroom. Following this, this research aimed to assess the impact of the use of informatics tools in the elementary grade level (age 6-7), as a support for an approach focused on translational symmetry patterns, in an environment of work project, in the development of geometric and technological skills. We opted for a multiple case study, essentially qualitative, that was developed in a context of action research. The main techniques and tools for data collection consisted in the direct and participant observation, supported by video and photographic record and a logbook where comments, behaviours and reactions of students were noted, and documental analysis of students' productions. Data analysis, descriptive and interpretative, was supported in representative transcriptions, scans and photos. The developed research allows concluding that a project work with students from low age reconciling informatics tools and mathematics, more specifically frieze patterns, contributes, effectively, to the development of transversal and specific mathematical and technologies skills.
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GOURDIAT, ANNE. "Atteintes neurologiques au decours d'infections a campylobacter : cinq observations." Clermont-Ferrand 1, 1988. http://www.theses.fr/1988CLF13015.
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Burette, Stéphanie. "La règle et l'écart. Paradoxe et évolution de la vraisemblance dans les discours sur la peinture (théorie de l'art et critique d'art) aux XVIIe et XVIIIe siècles." Thesis, Paris 3, 2014. http://www.theses.fr/2014PA030177.
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Cette thèse propose l’examen des textes de théorie de l’art et de critique d’art portant sur la peinture en France, aux XVIIe et XVIIIe siècle, suivant l’angle de la vraisemblance. De nombreuses réflexions sur la légitimité de la critique de ceux qui ne pratiquent pas la peinture ont précédé la naissance de la critique d’art, et la question fait toujours débat au XVIIIe siècle. Or, la notion de vraisemblance, présente dans le discours des théoriciens (peintres ou non) du point de vue de la réalisation des œuvres, manifeste la prise en compte d’un regard porté sur le tableau, c’est-à-dire du point de vue de la réception : est-ce que l’ « on » peut croire à ce que le tableau représente ? Ce que nous souhaitons montrer est le rôle crucial que joue la vraisemblance dans la légitimation de la critique d’art. Si un spectateur, qui n’est pas peintre, n’est pas à même de juger la qualité du dessin ou du coloris dans une œuvre, il est en droit de dire si ce que le tableau lui présente est vraisemblable ou non.Notre étude cherche à comparer les différentes acceptions que le terme de vraisemblance prend sous la plume des théoriciens et des critiques, afin d’une part de mettre en évidence que cette notion est considérée des deux côtés comme une règle en peinture, et de préciser son évolution dans les discours au XVIIIe sThis thesis offers to examine theory of art and art criticism texts about painting in 17th and 18th c. France, via the angle of verisimilitude. Numerous thoughts upon the legitimacy of the criticism of those who do not practice painting have preceded the birth of art criticism, and the debate is still going on during the 18th c. However, the notion of verisimilitude, present in art theory discourses (by painters or not) about the creation of an art piece, manifests that the perception of the painting by someone looking at it is taken into account, this time from the point of view of reception: can “one” believe what the painting shows? We aim at proving the crucial role of verisimilitude in giving art critic legitimacy. If a spectator – who is not a painter – has no legitimacy to judge the quality of drawing or colour in an art piece, he can say whether the painting is credible or not.We compare and study the several acceptations of verisimilitude in theorists and critics’ writings in order to highlight that the notion is considered as a rule of painting on both sides, and analyse its evolution in 18th c. discourses
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Soares, Helena Cristina Mendes. ""The Chinese Phytotherapy: Oriental and Western Pathophysiological Aspects and Perpectives - The Example of Ephedrae Decotum"." Master's thesis, Instituto de Ciências Biomédicas Abel Salazar, 2009. http://hdl.handle.net/10216/26363.
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Soares, Helena Cristina Mendes. ""The Chinese Phytotherapy: Oriental and Western Pathophysiological Aspects and Perpectives - The Example of Ephedrae Decotum"." Dissertação, Instituto de Ciências Biomédicas Abel Salazar, 2009. http://hdl.handle.net/10216/26363.
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Brito, Jorge Alexandre Completo. "Equity research - Floor & Decor." Master's thesis, Instituto Superior de Economia e Gestão, 2020. http://hdl.handle.net/10400.5/20911.
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Mestrado em FinançasEste projeto consiste numa Equity Research sobre a FLOOR & DECOR (FND), uma empresa norte-americana do setor de Renovação de Casas cujo negócio se foca na oferta de pisos de superfície dura e acessórios relacionados ao lar. O artigo integra o projeto de trabalho final do Mestrado em Finanças do ISEG e segue as recomendações do formato do CFA Institute baseando-se na informação financeira da empresa publicamente disponível até 26 de dezembro de 2019. O modelo aplicado a este projeto de Equity Research foi o modelo de Fluxo de Caixa Descontado (DCF). O presente artigo contempla uma projeção de 5 anos, de 2020 a 2024, a partir de 2024 as projeções foram feitas por meio de uma avaliação terminal e como método de avaliação complementar foi escolhido o método de Avaliação Relativa. Esta avaliação concluiu um preço alvo de $ 91.09 por ação 2020YE, o que representa um potencial de aumento de 10% quando comparado com o valor de $ 83,01 por ação em 4 de novembro de 2020. A recomendação proposta por este artigo é uma recomendação de manutenção da carteira com risco médio. A empresa foi significativamente impactada pela pandemia COVID-19 desde março de 2020, que se refletirá nas suas vendas líquidas, porém espera-se que o mercado onde a FND se insere comece a ter uma recuperação progressiva a partir de 2021, à medida que a economia dos EUA recupera.
This project consists of an Equity Research on FLOOR & DECOR (FND), an U.S. company in the home improvement industry which business is focused on offering hard surface flooring and home related accessories. The article integrates the final work project of ISEG's Master in Finance and it follows the CFA Institute format recommendations and it is based on the company's publicly available financial information until the 26th of December 2019. The model applied to this equity research project was the Discounted Cash Flow (DCF) model. The time frame forecasted was 5 years, from 2020 to 2024, from 2024 onwards the projections were made using a terminal valuation and as a complementary valuation method, the Relative Valuation method was chosen. That valuation led to a price target of $91.09 per share 2020YE which represents an upside potential of 10% when comparing with the value of $83.01 per share on November 4, 2020. The recommendation proposed by this report is a Hold recommendation with medium risk. The Company was significantly impacted by the COVID-19 pandemic since March 2020 which will be reflected in its net sales, however it is expected that the market where FND belongs will start to make a progressive recovery starting 2021 as well as the U.S. economy.
info:eu-repo/semantics/publishedVersion
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Strazynski, Marco. "Induktion der Decorin-Synthese in Endothelzellen durch Wechselwirkung mit Fibroblasten." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969065841.
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Lavigne, Frédéric. "Sémantique isochronotopique : locus et decours temporel des processus d'interprétation sémantique." Paris, EHESS, 1996. http://www.theses.fr/1996EHES0312.
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Les phenomenes de construction du sens au cours de la comprehension d'enonces font intervenir de nombreux parametres relevant notamment des proprietes du langage et du systeme cognitif. Les bases minimales des interactions systemiques entre un lecteur et un enonce montrent l'interet interdisciplinaire d'apprehender les phenomenes semantiques par l'analyse conjointe de la structure linguistique anaphorique associative de l'enonce et des processus cognitifs interpretatifs. Les questions theoriques posees par les processus en temps reel de l'interpretation nous amenent a preciser empiriquement les interactions entre les representations que se fait le sujet de l'enonce et la structure semantique de l'enonce. L'analyse empirique des processus interpretatifs s'inscrit, en psychologie cognitive, dans la problematique des effets du contexte semantique sur la reconnaissance des mots, etudiee par une serie d'experiences d'enregistrement des mouvements oculaires pendant la lecture et de decision lexicale. Les resultats conduisent a distinguer plusieurs types d'interpretation du sens des mots en fonction du contexte qui les precede, et en fonction de la dimension temporelle des processus interpretatifs. Dans le cadre de l'analyse structurale des phenomenes d'isotopie, l'analyse de la temporalite des effets du contexte permet de degager des decours temporel distincts des processus activateurs et inhibiteurs du traitement semantique. Ces proprietes fonctionnelles sont analysees sur un plan qualitatif des types d'associations lexicales mises en jeu dans la phrase, puis sont elargies a un plan quantitatif vers la notion de thematique globale du niveau textuel. Un modele interpretatif psycholinguistique est propose pour rendre compte de maniere unifiee des processus interpretatifs activateurs et inhibiteurs. Des elements de formalisation sont proposes relativement aux proprietes structurales d'un reseau de neurones. Ce travail propose une approche interdisciplinaire d'une theorie semantique lexicale, structurale et temporelleSentence comprehension processes rely on semantic properties of the linguistic system and of the cognitive system. An analysis of systemic interactions between a text and a reader is proposed. This analysis defines the types of interactions between an associative anaphoric structure and an associative cognitive structure, usually investigated from different disciplinary point of views. On the basis of this theoretical anaysis, an experimental approach is proposed within the frame of semantic context effects studies in psycholinguistics. A set of eye movement recording experiments, and of lexical decision experiments, investigates the locus and time course of context effects on word processing. Results show that both the semantic structure of the context and the time course of the context effects can influence the processing of a target word. Results are discussed within the linguistic frame of isotopic phenomenon, and show that both activatory and inhibitory processes are involved, with different time courses. These results are extended from the reading of isolated sentences to the reading of texts. A psycholinguistic associative model is proposed within the frame of the current literature, which propose to analyse at an associative level the activatiry and inhibitory processes and their respective time courses
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Brown, Andrew S. "Two-dimensional Polyacrylamide Gel Electrophoresis (2D-PAGE) Characterization of Decorin." Youngstown State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1311873768.
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Guimarães, Maria de Fátima Araújo. "Ética, decoro parlamentar e a desscralização do Senado republicano." reponame:Repositório Institucional da UnB, 2010. http://repositorio.unb.br/handle/10482/8560.
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Tese (doutorado)–Universidade de Brasília, Departamento de História, 2010.Submitted by wiliam de oliveira aguiar (wiliam@bce.unb.br) on 2011-06-21T16:28:01Z No. of bitstreams: 1 2010_MariadeFátimaAraújoGuimarães.pdf: 1812621 bytes, checksum: ffb3bc7c02fcfa4431622034e0b8a2e2 (MD5)
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Esta Tese trata da reconstrução da trajetória republicana do Senado Federal, com o objetivo de demonstrar como a idéia de superioridade atribuída àquela Casa reduziu-se ao longo do tempo e como o Senado brasileiro afastou-se do ‘terreno sagrado’ que ocupava na fase inicial de sua existência, quando era visto como um ambiente ‘sério’ e composto por ‘dignos’ senhores e, por tais características, inviolável diante de sua honradez e respeitabilidade. As reflexões aqui apresentadas basearam-se em referências teóricas de pensadores vinculados à História Cultural. A partir de tal referencial analisou-se parte da documentação disponível sobre a trajetória republicana do Senado Federal, com foco na articulação do discurso sobre ética e decoro parlamentar no período de 120 anos (1889-2009) e na explicitação de como os códigos de conduta senatoriais foram construídos e alterados ao longo desses anos. Neste estudo foram analisados alguns casos representativos de práticas conflitantes com a ética e com o decoro parlamentar que resultaram em cassações e renúncias, em perdas de mandato. Nesta reflexão enfatizou-se as características fundamentais do discurso sobre ética e decoro produzido no seio da instituição parlamentar, bem como nos segmentos representativos da sociedade civil e repercutido nos principais veículos de comunicação brasileiros. O período republicano marca o distanciamento do Senado da idéia de ‘sacralidade’, de um ambiente intocado ostentado anteriormente, sendo decisivo para a construção desse novo cenário os fatos inerentes ao processo de democratização verificado no País nas últimas décadas do século XX e início do século XXI (1979-2009). Com a democratização explicitaram-se as conseqüências das interferências externas e as mazelas internas produzidas pela própria Instituição. Na democracia os escândalos envolvendo senadores se tornaram frequentes, fazendo com que a idéia de ‘superioridade’ do Senado fosse minimizada e que o status de Câmara Alta e de casa ‘aristocrática’ aos poucos se desfizesse, confirmando assim, o que aqui se denomina como a dessacralização do Senado brasileiro. _________________________________________________________________________________ ABSTRACT
This thesis is about the reconstruction of the republican pathway of the Brazilian Senate. Its goal is to demonstrate how the idea of superiority attributed to that Institution has been reduced all over these years and how the Brazilian Senate strayed of the ‘sacred land’ that it had occupied in the beginning of its existence, when it was seen as a ‘serious place’ which was composed by ‘dignified’ gentlemen and inviolable because of those features and before its honorableness and respectability. The reflections presented here had been based on theoretical references of thinkers linked to the Cultural History. From that referential, part of the available documentation of the Federal Senate was analyzed, focusing on the speech articulation about ethics and parliamentary decorum in the period of 120 years (1889-2009) and on the explanation of how the senatorial codes of behavior were built and modified throughout these years. In this study were analyzed some representative cases of conflicting practices with the ethic and the parliamentary decorum that resulted in abrogation, renouncements and mandates losses. In this reflection, were emphasized the basic characteristics of the speech on ethics and honor produced in the bosom of the parliamentary institution, as well as in the representative segments of the civil society, and that was reverberated in Brazilian main communication channels. The republican period marks the Senate detachment from the idea of ‘sacredness’ and of an untouched environment that was previously flaunted, being decisive for the construction of this new scene the inherent facts to the process of democratization verified in the Country in the last few decades of 20th century and the beginning of 21st century (1979-2009). With the democratization became explicit the consequences of the external interferences and of the internal wounds produced by the Institution. In democracy, scandals involving senators became frequent, minimizing the idea of Senate’s superiority and slowly undoing the status of Upper House and aristocratic house, thus confirming, what here is called the Brazilian Senate’s desecration.
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Fauvinet-Ranson, Valérie. "Decor civitatis, decor Italiae : monuments, travaux publics et spectacles au VIe siècle d'après les Variae de Cassiodore /." Bari : Edipuglia, 2006. http://www.loc.gov/catdir/toc/casalini06/06935980.pdf.
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Kelly, Dylan. "Crisis, Shell-Shock, and the Temporality of Trauma: Cultural Memory and the Great War Combatant Experience in Owen, Graves, and Barker." Honors in the Major Thesis, University of Central Florida, 2014. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/1604.
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The year 2014 will mark the centennial of the outbreak of World War I in August 1914. This historic anniversary will likely provoke several discussions from all fields in the humanities concerning the Great War's significance on contemporary culture through history, visual art, and in the case of this essay: literature. In light of this event, any serious discussion among scholars should undeniably begin with how the war continues to be represented today through a thorough, contemporary analysis of its many key literary texts. This essay will examine, in this regard, how past and contemporary discourses in literary theory-primarily concerned with how an individual combatant subject attempts to construct and understand their own traumatic experiences through poetic and literary discourse-can continue to incite discussion on why literature of the Great War and its influential role in defining how it has come to be understood in our cultural memory remains relevant even today. Under the guiding influence of Paul Fussell's classic The Great War and Modern Memory, I will discuss how three important works-a poetry collection, a memoir, and a modern work of historical fiction-all contribute to how the war has become represented as a tragic rupture in history that reversed the idea of human progress and left an entire generation disillusioned in its aftermath, regardless of the historical veracity of this legacy. The texts I will be examining include: select poems of Wilfred Owen, Goodbye to All That by Robert Graves, and Regeneration by Pat Barker. In addition to this, I will conclude with an analysis of how a contemporary reading of these texts can contribute to a larger discussion of the crisis of historicity in our current post-modern cultural landscape.B.A.
Bachelors
English
Arts and Humanities
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Islam, Mehwaesh. "Biochemical analysis of collagen binding by invertebrate SPARC and engineered monomeric decorin." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/24664.
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Collagens are a family of extracellular matrix proteins that are critically important for providing structural support to tissues and for regulating cell behaviour. The thesis describes the biochemical analysis of collagen binding by two globular proteins that profoundly influence collagen fibril formation in vivo, decorin and SPARC. Decorin is the archetypal small leucine-rich repeat proteoglycan and an important regulator of collagen fibrillogenesis. The crystal structure of decorin, published in 2004, revealed a dimeric structure in which the presumed collagen binding site was not accessible. Whether the dimer is functional has been controversial, however, and it has been claimed that biologically active decorin is monomeric. In order to resolve this controversy, I designed a number of decorin mutants to disrupt the crystallographic dimer, including two mutants which introduced glycosylation sites into the dimer interface. Size exclusion chromatography with multi-angle laser light scattering and analytical ultracentrifugation were used to determine the oligomeric states of decorin and the designed mutants. I found that wild-type decorin dimerises in solution with a dissociation constant of ~1 μM. The mutants with engineered glycosylation sites were pure monomers while other mutants remained dimeric. Thermal unfolding experiments showed that the engineered decorin monomers were as stable as wild-type decorin. Mutations on the concave face of decorin abolished collagen binding, regardless of whether the mutant proteins retained the ability to dimerise or not. Thus the concave face of decorin is involved in collagen binding and the dimer must dissociate in order to bind collagen. The crystal structure of human SPARC bound to a collagen-like triple-helical peptide was determined in the Hohenester lab in 2008. The key collagen binding residues are conserved between human and invertebrate (Drosophila and C. elegans) SPARCs. There is a key difference between the orthologues, however: high-affinity collagen binding to human SPARC requires proteolytic cleavage of an inhibitory loop that is absent from invertebrate SPARCs. To investigate the functional consequences of this structural difference for collagen binding, I compared the interactions of the different SPARCs with collagen I and IV, using solid-phase assays and surface plasmon resonance. I found that invertebrate SPARCs did not bind collagen more tightly than human SPARC, suggesting that the absence of the inhibitory loop does not confer a higher affinity for collagen in invertebrate SPARCs. I made several unsuccessful attempts to crystallise an invertebrate SPARC, including experiments in which the glycan was trimmed by endoglycosidase digestion or removed by mutagenesis of acceptor sites.
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Ribeiro, Bruno Leonardo Marroig de Freitas. "Análise imunohistoquímica dos proteoglicanossindecan, decorin e biglican na próstata normal e hiperplásica." Universidade do Estado do Rio de Janeiro, 2011. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=9080.
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Os mecanismos celulares envolvidos na hiperplasia prostática benigna (HPB) não são bem compreendidos e pouco se sabe sobre como os proteoglicanos estão relacionados com esta condição. Neste estudo foi avaliada a expressão de proteoglicanos de superfície celular e do estroma na HPB. As amostras de próstata com HPB foram colhidas de pacientes submetidos à prostatectomia aberta e ressecção transuretral da próstata (RTUP), enquanto as amostras do grupo controle consistiram na zona de transição de próstatas normais de adultos jovens. Foram usados anticorpos primários anti-sindecan-1, anti-biglican e anti-decorin. A imunomarcação foi avaliada determinando-se a área relativa marcada pelo anticorpo, ou usando-se um escore atribuído à intensidade da coloração. Os resultados mostraram que, no grupo controle, a expressão do sindecan-1 foi mínima ou nula. Na HPB, no entanto, a imunomarcação deste proteoglicano foi intensa e localizada principalmente nas células basais do ácino prostático e com menor intensidade na superfície basolateral das células secretoras. Como não houve diferença entre as amostras obtidas através da prostatectomia aberta e da RTUP, esses grupos foram combinados em um único grupo HPB. A área marcada pelo anticorpo anti-sindecan-1 no epitélio das amostras de HPB foi nove vezes maior do que na próstata normal (p<0,001), e não houve correlações significativas entre a marcação do sindecan-1naHPB e o volume da próstata, o PSA ou a idade do paciente. Quanto ao biglican e ao decorin, a marcação foi exclusivamente no estroma, tanto no grupo controle quanto no grupo HPB, e não houve diferença significativa na extensão e intensidade da coloração entre estes dois grupos. Em conclusão, a imunomarcação do sindecan-1 na HPB é intensa e está localizada no epitélio glandular exclusivamente, mas a intensidade não se correlaciona com o tamanho da próstata ou PSA. A expressão do decorin e do biglican, no entanto, não foi alterada na HPB.The cellular mechanisms involved in benign prostatic hyperplasia (BPH) are not well understood, and little is known about how proteoglycans are affected. Here we investigated the protein expression of stromal and cell surface proteoglycans in BPH. BPH samples were colected from open prostatectomy and transurethral resection of the prostate (TURP), while controls consisted of the transitional zone of normal prostates from young adults. We used primary antibodies against the proteoglycans syndecan-1, biglycan, and decorin. Immunolabeling was evaluated by determining the relative area of staining, or by using a score for staining intensity. The results showed that, in controls, syndecan-1 was mostly negative. In BPH, however, the labeling of this proteoglycan was intense and located mainly in acinar basal cells, but could extended into the secretory cells. As there were no differences in samples from open prostatectomy and TURP, these groups were combined into a BPH group. Syndecan-1 labeling area in the epithelium of BPH samples was nine times greater than that of controls (p<0,001), and there were no significant correlations between syndecan-1 labeling in BPH and prostate volume, PSA, or patients age. Biglycan and decorin labeling were in the stroma exclusively, in control and BPH samples, and there were no significant differences in extent and intensity of the staining between these two groups. In conclusion, syndecan-1 immunolabeling in BPH is prominent and is located in the glandular epithelium exclusively, but intensity does not correlate with prostate size or PSA. Decorin and biglycan labeling, however, were unchanged in BPH.
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DEPECKER, LAURENCE. "De la realite du syndrome autistique au decours du syndrome de west." Angers, 1990. http://www.theses.fr/1990ANGE1077.
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Modesto, Irene <1978>. "Decorso delle coliti severe: un confronto tra colite ulcerosa e di Crohn." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amsdottorato.unibo.it/5500/1/Decorso_delle_coliti_severe_-_un_confronto_tra_colite_ulcerosa_e_di_Crohn.pdf.
Full textAbstract:
Pochi sono i dati disponibili sul decorso clinico della malattia di Crohn del colon severa(CD). L'obiettivo è quello di descrivere il decorso clinico della colite di Crohn severa (CC) in una coorte di pazienti isolata con CD del colon o ileocolica, e di confrontarlo con il decorso clinico di pazienti affetti da colite ulcerosa severa (UC). 34 pazienti con CC severa sono stati identificati retrospettivamente nella nostra coorte di 593 pazienti ricoverati (2003-2012) attraverso la valutazione di CDAI score e HBI. 169 pazienti con UC severa sono stati identificati retrospettivamente in una coorte di 449 pazienti ricoverati (2003-2012) attraverso la valutazione del score di Lichtiger e di Truelove-Witts. Abbiamo valutato questi risultati: risposta agli steroidi, risposta ai farmaci biologici, tasso di colectomia acuta, tasso di colectomia durante il follow-up, megacolon e tasso di infezione da citomegalovirus. Non abbiamo trovato differenze significative nella risposta agli steroidi e biologici, della percentuale di infezione da citomegalovirus e di megacolon, mentre il tasso di colectomia in acuto è risultato essere maggiore nei pazienti con CC rispetto ai pazienti con UC; anche la differenza tra i tassi di colectomia alla fine del follow-up è risultata non significativa. Con l'analisi univariata la giovane età alla diagnosi è associata ad un aumentato rischio di colectomia in assoluto (p = 0,024) e in elezione (p = 0.022), ma non in acuto. Il tasso globale di colectomia nei pazienti con CC severa è superiore a quella dei pazienti con UC severa , ma questo dato non è supportato da una diversa risposta clinica alla terapia steroidea o terapia di salvataggio con biologici. Il vero decorso clinico della colite di Crohn severa necessita di essere chiarito da studi prospettici che includano un numero maggiore di pazienti con questo sottogruppo di malattia.Few data are available about the clinical course of severe colonic Crohn’s disease (CD). The aim is to describe the clinical course of severe Crohn’s colitis (CC) in a patients cohort with isolated colonic or ileocolonic CD, and to compare it with the clinical course of patients with severe ulcerative colitis (UC). 34 Patients with severe CC were retrospectively identified in our cohort of 593 hospitalized patients (2003-2012) through the evaluation of CDAI score and HBI. 169 Patients with severe UC were retrospectively identified in our cohort of 449 hospitalized patients (2003-2012) through the evaluation of Lichtiger score and Truelove-Witts score. We evaluated these outcomes: response to steroids, response to biologics, acute colectomy rate, colectomy rate during follow-up, megacolon and cytomegalovirus infection rate. We did not find significant differences in the response to steroids and to biologics, in the percentage of cytomegalovirus infection and of megacolon, while the rate of colectomy in acute turned out to be greater in patients with severe CC compared to patients with severe UC, and this difference appeared to be the limit of statistical significance (Chi square 3.31, p = 0.069, OR 0.39); the difference between the colectomy rates at the end of follow up was also not significant. By univariate analysis a young age at diagnosis is associated with an increased risk of colectomy in absolute (p = 0.024) and in election (p = 0.022), but not in acute. The overall rate of colectomy in patients with severe CC is greater than that of patients with severe UC, but this figure is not to be supported by a different clinical response to steroid therapy or rescue therapy with biologics.The real clinical course of severe CC requires to be clarified by prospective studies that include a larger number of patients in this subgroup of disease.
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Modesto, Irene <1978>. "Decorso delle coliti severe: un confronto tra colite ulcerosa e di Crohn." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amsdottorato.unibo.it/5500/.
Full textAbstract:
Pochi sono i dati disponibili sul decorso clinico della malattia di Crohn del colon severa(CD). L'obiettivo è quello di descrivere il decorso clinico della colite di Crohn severa (CC) in una coorte di pazienti isolata con CD del colon o ileocolica, e di confrontarlo con il decorso clinico di pazienti affetti da colite ulcerosa severa (UC). 34 pazienti con CC severa sono stati identificati retrospettivamente nella nostra coorte di 593 pazienti ricoverati (2003-2012) attraverso la valutazione di CDAI score e HBI. 169 pazienti con UC severa sono stati identificati retrospettivamente in una coorte di 449 pazienti ricoverati (2003-2012) attraverso la valutazione del score di Lichtiger e di Truelove-Witts. Abbiamo valutato questi risultati: risposta agli steroidi, risposta ai farmaci biologici, tasso di colectomia acuta, tasso di colectomia durante il follow-up, megacolon e tasso di infezione da citomegalovirus. Non abbiamo trovato differenze significative nella risposta agli steroidi e biologici, della percentuale di infezione da citomegalovirus e di megacolon, mentre il tasso di colectomia in acuto è risultato essere maggiore nei pazienti con CC rispetto ai pazienti con UC; anche la differenza tra i tassi di colectomia alla fine del follow-up è risultata non significativa. Con l'analisi univariata la giovane età alla diagnosi è associata ad un aumentato rischio di colectomia in assoluto (p = 0,024) e in elezione (p = 0.022), ma non in acuto. Il tasso globale di colectomia nei pazienti con CC severa è superiore a quella dei pazienti con UC severa , ma questo dato non è supportato da una diversa risposta clinica alla terapia steroidea o terapia di salvataggio con biologici. Il vero decorso clinico della colite di Crohn severa necessita di essere chiarito da studi prospettici che includano un numero maggiore di pazienti con questo sottogruppo di malattia.Few data are available about the clinical course of severe colonic Crohn’s disease (CD). The aim is to describe the clinical course of severe Crohn’s colitis (CC) in a patients cohort with isolated colonic or ileocolonic CD, and to compare it with the clinical course of patients with severe ulcerative colitis (UC). 34 Patients with severe CC were retrospectively identified in our cohort of 593 hospitalized patients (2003-2012) through the evaluation of CDAI score and HBI. 169 Patients with severe UC were retrospectively identified in our cohort of 449 hospitalized patients (2003-2012) through the evaluation of Lichtiger score and Truelove-Witts score. We evaluated these outcomes: response to steroids, response to biologics, acute colectomy rate, colectomy rate during follow-up, megacolon and cytomegalovirus infection rate. We did not find significant differences in the response to steroids and to biologics, in the percentage of cytomegalovirus infection and of megacolon, while the rate of colectomy in acute turned out to be greater in patients with severe CC compared to patients with severe UC, and this difference appeared to be the limit of statistical significance (Chi square 3.31, p = 0.069, OR 0.39); the difference between the colectomy rates at the end of follow up was also not significant. By univariate analysis a young age at diagnosis is associated with an increased risk of colectomy in absolute (p = 0.024) and in election (p = 0.022), but not in acute. The overall rate of colectomy in patients with severe CC is greater than that of patients with severe UC, but this figure is not to be supported by a different clinical response to steroid therapy or rescue therapy with biologics.The real clinical course of severe CC requires to be clarified by prospective studies that include a larger number of patients in this subgroup of disease.