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Journal articles on the topic 'DDR II'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Krüger, W., and L. Schubert. "Spannbetonberechnung im Zustand II nach DDR-Vorschriften." Beton- und Stahlbetonbau 84, no. 5 (1989): 109–15. http://dx.doi.org/10.1002/best.198900180.

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2

Wang, Xiaoyan, Fengmin Li, Pedro A. Jose, and Carolyn M. Ecelbarger. "Reduction of renal dopamine receptor expression in obese Zucker rats: role of sex and angiotensin II." American Journal of Physiology-Renal Physiology 299, no. 5 (2010): F1164—F1170. http://dx.doi.org/10.1152/ajprenal.00604.2009.

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Dopamine produced by renal proximal tubules increases sodium excretion via a decrease in renal sodium reabsorption. Dopamine natriuresis is impaired in obese Zucker rats; however, the mechanism is not fully understood. To test the hypothesis that renal expression of one or more of the subtypes are altered in these rats, we measured whole kidney protein levels by immunoblotting of D1-like (D1R and D5R) and D2-like (D2R, D3R, and D4R) dopamine receptors in both male and female obese and lean Zucker rats. In obese males on 1% NaCl diet, D1R, D2R, D4R, and D5R were decreased, while D3R was increas

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3

Schönherr, M., R. Grunow, and G. Vetterlein. "II. Symposium DDR - UdSSR „Gentechnik in der Biotechnologie”︁." Acta Biotechnologica 6, no. 1 (1986): 3–5. http://dx.doi.org/10.1002/abio.370060102.

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4

Golan, Talia, Gauri R. Varadhachary, Tal Sela, et al. "Phase II study of olaparib for BRCAness phenotype in pancreatic cancer." Journal of Clinical Oncology 36, no. 4_suppl (2018): 297. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.297.

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297 Background: The subtype of pancreatic ductal adenocarcinoma cancer (PDAC) patients with DNA damage repair (DDR) deficiency from BRCA1/2 mutations has a favorable prognosis and is sensitive to platinum analogues and PARP inhibition. About 10-20% of PDAC patients have DDR deficiency without BRCA mutations (BRCA ness). The efficacy of olaparib in this population is unknown. Methods: Two parallel phases II trials (Israel and U.S.) are ongoing to determine the efficacy of olaparib in advanced PDAC with BRCA ness. Inclusion criteria: ≥ 1 prior systemic therapy for advanced PDAC, ECOG 0-1, germli

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5

Silomon, Anke. "Lebenswege In Der DDR: II. Persönlichkeiten Aus Dem Staatlichen Bereich." Verkündigung und Forschung 43, no. 1 (1998): 40–51. http://dx.doi.org/10.14315/vf-1998-0105.

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6

Owens, Gary K. "Determinants of angiotensin II-induced hypertrophy versus hyperplasia in vascular smooth muscle." Drug Development Research 29, no. 2 (1993): 83–87. http://dx.doi.org/10.1002/ddr.430290203.

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7

Kosmider, Beata, and Regina Osiecka. "Flavonoid compounds: a review of anticancer properties and interactions withcis-diamminedichloroplatinum(II)." Drug Development Research 63, no. 4 (2004): 200–211. http://dx.doi.org/10.1002/ddr.10421.

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8

Harboe-SØrensen, Reno, F. X. Guerre, and G. Lewis. "Heavy-Ion SEE Test Concept and Results for DDR-II Memories." IEEE Transactions on Nuclear Science 54, no. 6 (2007): 2125–30. http://dx.doi.org/10.1109/tns.2007.909747.

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9

Luan, Zhaoji, Baoliang Liu, and Lina Shi. "Angiotensin II‐induced micro RNA‐21 culprit for non‐small‐cell lung adenocarcinoma." Drug Development Research 80, no. 8 (2019): 1031–39. http://dx.doi.org/10.1002/ddr.21597.

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10

Pannirselvam, Malarvannan, Todd J. Anderson, and Chris R. Triggle. "Endothelial cell dysfunction in type I and II diabetes: The cellular basis for dysfunction." Drug Development Research 58, no. 1 (2003): 28–41. http://dx.doi.org/10.1002/ddr.10127.

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11

Phillips, Cameron, Giulio Francia, Robert S. Kerbel, and Urban Emmenegger. "Personalized use of metronomic cyclophosphamide for DNA repair deficient castration-resistant prostate cancer: A phase II trial." Journal of Clinical Oncology 37, no. 7_suppl (2019): TPS346. http://dx.doi.org/10.1200/jco.2019.37.7_suppl.tps346.

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TPS346 Background: There is a continued need to identify novel targets for the treatment of metastatic, castration-resistant prostate cancer (mCRPC). DNA damage repair (DDR) aberrations are emerging as such a target: 20%-30% of mCRPCs harbor DDR gene aberrations, rendering tumors particularly sensitive to DNA damaging agents and poly ADP-ribose polymerase inhibitor (PARPi) therapy. 88% of men with DDR deficient mCRPC responded to the PARPi olaparib in a phase II trial, whereas in unselected mCRPC patients the metronomic use of the DNA damaging agent cyclophosphamide (CPA) resulted in response

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12

Dworkin, Steven I., Stephen T. Higgins, and Warren K. Bickel. "Contemporary research in behavioral pharmacology. Part II: Classical conditioning. Part III: Discriminative and reinforcing effects." Drug Development Research 20, no. 2 (1990): 141–44. http://dx.doi.org/10.1002/ddr.430200202.

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13

Chang, Raymond S. L., Robert J. Bendesky, Tsing-B. Chen, et al. "In vitro phamacology of MK-996, a new potent and selective angiotensin II (AT1) receptor antagonist." Drug Development Research 32, no. 3 (1994): 161–71. http://dx.doi.org/10.1002/ddr.430320306.

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14

Pershadsingh, Harrihar A. "New generation angiotensin II type 1 receptor antagonists that selectively modulate peroxisome proliferator-activated receptor-γ". Drug Development Research 67, № 8 (2006): 687–97. http://dx.doi.org/10.1002/ddr.20142.

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15

Witkin, Jeffrey M., and William J. A. Eiler II. "Antagonism of metabotropic glutamate group II receptors in the potential treatment of neurological and neuropsychiatric disorders." Drug Development Research 67, no. 9 (2006): 757–69. http://dx.doi.org/10.1002/ddr.20144.

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16

Silas, Yardena, Esti Singer, Koyeli Das, Norbert Lehming та Ophry Pines. "A combination of Class-I fumarases and metabolites (α-ketoglutarate and fumarate) signal the DNA damage response in Escherichia coli". Proceedings of the National Academy of Sciences 118, № 23 (2021): e2026595118. http://dx.doi.org/10.1073/pnas.2026595118.

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Class-II fumarases (fumarate hydratase, FH) are dual-targeted enzymes occurring in the mitochondria and cytosol of all eukaryotes. They are essential components in the DNA damage response (DDR) and, more specifically, protect cells from DNA double-strand breaks. Similarly, the gram-positive bacterium Bacillus subtilis class-II fumarase, in addition to its role in the tricarboxylic acid cycle, participates in the DDR. Escherichia coli harbors three fumarase genes: class-I fumA and fumB and class-II fumC. Notably, class-I fumarases show no sequence similarity to class-II fumarases and are of dif

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17

Pishvaian, Michael J., Hongkun Wang, Sarah Parenti, et al. "Final report of a phase I/II study of veliparib (Vel) in combination with 5-FU and oxaliplatin (FOLFOX) in patients (pts) with metastatic pancreatic cancer (mPDAC)." Journal of Clinical Oncology 37, no. 15_suppl (2019): 4015. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.4015.

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4015 Background: 17 – 25% of mPDACs harbor DNA damage response (DDR) mutations, the presence of which can be predictive of a response to platinum and PARP inhibitor-based therapy. The PARP inhibitor, Vel is a potent sensitizing agent for, and has been safely combined with DNA-damaging chemotherapies. Methods: We initiated a Phase I/II trial of Vel + FOLFOX in pts with mPDAC. Pts received standard mFOLFOX6 except without the 5FU bolus, Q2 weeks. For the Phase I portion, a 3+3 dose escalation of Vel identified a recommended Phase II dose of 200mg orally BID, days 1-7, Q2 weeks. For the Phase II

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18

Singh, Jai Pal, Todd R. Wiernicki, and Shalley K. Gupta. "Role of serine/threonine kinase casein kinase-II in vascular smooth muscle cell proliferation and inhibition by heparin." Drug Development Research 29, no. 2 (1993): 129–36. http://dx.doi.org/10.1002/ddr.430290208.

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19

Barbi, Giorgio, Clinton N. Corder, Eugen Koren, Walter McConathy, S. Q. Ye, and Paul Wilson. "Effect of pravastatin and cholestyramine on triglyceride-rich lipoprotein particles and Lp(a) in patients with type II hypercholesterolemia." Drug Development Research 27, no. 3 (1992): 297–306. http://dx.doi.org/10.1002/ddr.430270309.

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20

Wendt, Hella. "Beiträge zur Insektenfauna der DDR: Coleoptera - Bruchidae (Chrysomeloidea). II. Bestimmungstabellen der heimischen Arten." Mitteilungen aus dem Museum für Naturkunde in Berlin. Zoologisches Museum und Institut für Spezielle Zoologie (Berlin) 64, no. 2 (1988): 311–18. http://dx.doi.org/10.1002/mmnz.19880640207.

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21

Wendt, Hella. "Beiträge zur Insektenfauna der DDR: Coleoptera – Bruchidae (Chrysomeloidea). II. Bestimmungstabellen der heimischen Arten." Mitteilungen aus dem Museum für Naturkunde in Berlin. Zoologisches Museum und Institut für Spezielle Zoologie 〈Berlin〉 64, no. 2 (1988): 311–18. http://dx.doi.org/10.1002/mmnz.4830640207.

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22

Giardina, William J., Steven A. Buckner, Michael E. Brune, et al. "A-80426, a potent and selective ?2-adrenoceptor antagonist with serotonin uptake-blocking activity and putative antidepressant-like effects: II. Pharmacology profile." Drug Development Research 35, no. 4 (1995): 246–60. http://dx.doi.org/10.1002/ddr.430350406.

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23

Thota, Ramya, Gail Fulde, Mark Andrew Lewis, et al. "DNA damage repair (DDR) pathway defects in gastrointestinal (GI) malignancies." Journal of Clinical Oncology 36, no. 4_suppl (2018): 647. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.647.

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647 Background: The clinical significance of the genomic alterations associated with DDR pathway in GI tumors (besides MMR defects) is largely unknown. These patients can potentially derive benefit from targeted therapy with poly ADP ribose polymerase (PARP) inhibitors, which have already shown promising activity in ovarian, breast and prostate cancers. In this study, we investigated the frequency and clinical significance of DDR repair defects (other than MMR defects) in GI tumors. Methods: We performed a retrospective analysis of all patients who had tumor next generation sequencing performe

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24

Saavedra, Juan M., and Jaroslav Pavel. "Angiotensin II AT1 receptor antagonists inhibit the angiotensin-CRF-AVP axis and are potentially useful for the treatment of stress-related and mood disorders." Drug Development Research 65, no. 4 (2005): 237–69. http://dx.doi.org/10.1002/ddr.20027.

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25

Li, Wenliang, Zhu Zhu, Ning Xu, et al. "Alterations of DNA damage repair genes in Chinese colorectal cancer patients." Journal of Clinical Oncology 38, no. 15_suppl (2020): e16121-e16121. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e16121.

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e16121 Background: Colorectal cancer (CRC) is the second most common cancer in women and third in men. DNA damage repair (DDR) deficiency has emerged as a predictive biomarker for chemotherapy, PARP and immune checkpoint inhibitors. However, comprehensive molecular characteristics of DDR variants in Chinese CRC patients is lacking. Methods: Formalin fixed, paraffin embedded (FFPE) tumor tissues and matched blood samples were collected for targeted next-generation sequencing (NGS) assay. The testing was carried out in a College of American Pathologists (CAP) accredited and Clinical Laboratory I

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26

Prescott, Margaret Forney, and Wilbur K. Sawyer. "ACE inhibition versus angiotensin II, AT1 receptor antagonism: A review of effects on intimal lesion formation in animal models of vascular injury, restenosis, and atherosclerosis." Drug Development Research 29, no. 2 (1993): 88–93. http://dx.doi.org/10.1002/ddr.430290204.

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27

Fossa, Anthony A., Michael J. Depasquale, Laura J. Ringer, and Roxanne L. Winslow. "Synergistic effect on reduction in blood pressure with coadministration of a renin inhibitor or an angiotensin-converting enzyme inhibitor with an angiotensin II receptor antagonist." Drug Development Research 33, no. 4 (1994): 422–28. http://dx.doi.org/10.1002/ddr.430330405.

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28

Ma, Ke, Jun Peng, Huachuan Zhang, et al. "Contribution of DNA damage repair gene mutations and concomitant TP53 variations to the efficacy of platinum-based chemotherapy as initial therapeutic option in Chinese NSCLC patients." Journal of Clinical Oncology 38, no. 15_suppl (2020): e21002-e21002. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e21002.

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e21002 Background: Though targeted, immune-, even combinational therapies have been applied widely, platinum-based chemotherapy still plays irreplaceable role as initial management for patient with either resected or advanced NSCLC without actionable target. Platinum is sought to increase DNA damage burden inducing cell death, especially in cells with intrinsic DNA damage repair (DDR) dysfunction. This study aims to explore impact of DDR genes as well as co-occurrence of TP53 mutations on prognosis of NSCLC patients. Methods: 110 NSCLC patients were consecutively recruited from 2016-2018. 508

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29

Golan, Talia, Sharon Halparin, Chani Stossel, et al. "ATM as a biomarker for DNA damage repair deficiency in pancreatic ductal adenocarcinoma." Journal of Clinical Oncology 35, no. 4_suppl (2017): 308. http://dx.doi.org/10.1200/jco.2017.35.4_suppl.308.

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308 Background: Approximately 15% of PDAC tumors display DNA damage repair (DDR) deficiency. Germline BRCA (gBRCA) mutation serves as a robust biomarker for the DDR deficiency. A subset of patients displays a similar clinical phenotype but lack the gBRCA mutation. Identification of these BRCA-like subset of patients remains a challenge and an alternative approach may include DDR functional assays. Here we suggest loss of the ATM protein as one of the biomarkers for the identification of the DDR deficiency signature in PDAC. Methods: Patients were identified from the Sheba pancreatic cancer dat

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30

Fiedler, E. "Die Entwicklung des Stahlbrückenbaues in der DDR bis zum Zeitpunkt der Wende - ein Rückblick (Teil II)." Stahlbau 70, no. 5 (2001): 317–28. http://dx.doi.org/10.1002/stab.200101210.

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31

Torrecilla, Ignacio, Judith Oehler, and Kristijan Ramadan. "The role of ubiquitin-dependent segregase p97 (VCP or Cdc48) in chromatin dynamics after DNA double strand breaks." Philosophical Transactions of the Royal Society B: Biological Sciences 372, no. 1731 (2017): 20160282. http://dx.doi.org/10.1098/rstb.2016.0282.

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DNA double strand breaks (DSBs) are the most cytotoxic DNA lesions and, if not repaired, lead to chromosomal rearrangement, genomic instability and cell death. Cells have evolved a complex network of DNA repair and signalling molecules which promptly detect and repair DSBs, commonly known as the DNA damage response (DDR). The DDR is orchestrated by various post-translational modifications such as phosphorylation, methylation, ubiquitination or SUMOylation. As DSBs are located in complex chromatin structures, the repair of DSBs is engineered at two levels: (i) at sites of broken DNA and (ii) at

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32

Iyer, Gopa, Arjun V. Balar, Matthew I. Milowsky, et al. "Multicenter Prospective Phase II Trial of Neoadjuvant Dose-Dense Gemcitabine Plus Cisplatin in Patients With Muscle-Invasive Bladder Cancer." Journal of Clinical Oncology 36, no. 19 (2018): 1949–56. http://dx.doi.org/10.1200/jco.2017.75.0158.

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Purpose Neoadjuvant chemotherapy followed by radical cystectomy (RC) is a standard of care for the management of muscle-invasive bladder cancer (MIBC). Dose-dense cisplatin-based regimens have yielded favorable outcomes compared with standard-dose chemotherapy, yet the optimal neoadjuvant regimen remains undefined. We assessed the efficacy and tolerability of six cycles of neoadjuvant dose-dense gemcitabine and cisplatin (ddGC) in patients with MIBC. Patients and Methods In this prospective, multicenter phase II study, patients received ddGC (gemcitabine 2,500 mg/m2 on day 1 and cisplatin 35 m

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33

Schiemann, X. "Die Geschäftsbeziehungen zwischen der Kunst und Antiquitäten GmbH der DDR und dem Londoner Auktionshaus Christie’s (Teil II)." KUR - Kunst und Recht 22, no. 3-4 (2020): 77–81. http://dx.doi.org/10.15542/kur/2020/3-4/3.

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34

Wartlick, Friedrich, Anita Bopp, Christian Henninger, and Gerhard Fritz. "DNA damage response (DDR) induced by topoisomerase II poisons requires nuclear function of the small GTPase Rac." Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1833, no. 12 (2013): 3093–103. http://dx.doi.org/10.1016/j.bbamcr.2013.08.016.

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35

Chau, Vincent, Ravi Amrit Madan, Marijo Bilusic, et al. "Anaplastic features (AnaF) and DNA-damage repair pathway (DDR) mutations in metastatic castration-resistant prostate cancer (mCRPC)." Journal of Clinical Oncology 39, no. 6_suppl (2021): 92. http://dx.doi.org/10.1200/jco.2021.39.6_suppl.92.

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92 Background: Anaplastic prostate cancer displays features of small-cell carcinoma, a type of neuroendocrine tumor. Treatments for anaplastic prostate cancer are based on small cell lung cancer regimens. Both AnaF and mutations in DDR pathways, including BRCA2 confer an aggressive phenotype. For patients (pts) with certain DDR mutations, olaparib (O) was recently FDA approved, and an ongoing study is evaluating whether the addition of durvalumab (D) confers additional benefit in mCRPC (NCT02484404). We evaluate a potential preliminary relationship between DDR mutations, treatment with D and O

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36

Schroeder, Friedrich-Christian. "I. Fahnenschmidt, Willi, DDR-Funktionäre vor Gericht. Die Strafverfahren wegen Amtsmissbrauch und Korruption im letzten Jahr der DDR und nach der Vereinigung. II. Rummler, Toralf, Die Gewalttaten an der deutsch-deutschen Grenze vor Gericht. III. Thiemrodt, Ivo, Strafjustiz und DDR-Spionage. Zur Strafverfolgung ehemaliger DDR-Bürger wegen Spionage gegen die Bundesrepublik. IV. Hohoff, Ute, An den Grenzen des Rechtsbeugungstatbestandes. Eine Studie zu den Strafverfahren gegen DDR-Juristen. V. Müller, Jan, Symbol 89 – Die DDR-Wahlfälschungen und ihre strafrechtliche Aufarbeitung." Zeitschrift der Savigny-Stiftung für Rechtsgeschichte: Germanistische Abteilung 119, no. 1 (2002): 1046–47. http://dx.doi.org/10.7767/zrgga.2002.119.1.1046b.

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37

Yura, Yoshimitsu, Emiri Miura-Yura, Yasufumi Katanasaka, et al. "The Cancer Therapy-Related Clonal Hematopoiesis Driver Gene Ppm1d Promotes Inflammation and Non-Ischemic Heart Failure in Mice." Circulation Research 129, no. 6 (2021): 684–98. http://dx.doi.org/10.1161/circresaha.121.319314.

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Rationale: Cancer therapy can be associated with short- and long-term cardiac dysfunction. Patients with cancer often exhibit therapy-related clonal hematopoiesis (t-CH), an aggressive form of clonal hematopoiesis that can result from somatic mutations in genes encoding regulators of the DNA-damage response (DDR) pathway. Gain-of-function mutations in exon 6 of the protein phosphatase Mg2+/Mn2+ dependent 1D ( PPM1D ) gene are the most frequently mutated DNA-damage response gene associated with t-CH. Whether t-CH can contribute to cardiac dysfunction is unknown. Objective: We evaluated the caus

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38

Congdon, Lee, and Jan Herman Brinks. "Die DDR-Geschichtswisenschaft auf dem Weg zur deutschen Einheit: Luther, Friedrich II und Bismarck als Paradigmen Politischen Wandels." American Historical Review 100, no. 2 (1995): 546. http://dx.doi.org/10.2307/2169102.

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39

Otto, Martin. "II. Booß, Christian, Im goldenen Käfig. Zwischen SED, Staatssicherheit, Justizministerium und Mandant – die DDR-Anwälte im politischen Prozess." Zeitschrift der Savigny-Stiftung für Rechtsgeschichte: Germanistische Abteilung 135, no. 1 (2018): 452. http://dx.doi.org/10.26498/zrgga-2018-1350128.

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40

Mateo, Joaquin, Nuria Porta, Ursula Brigid McGovern, et al. "TOPARP-B: A phase II randomized trial of the poly(ADP)-ribose polymerase (PARP) inhibitor olaparib for metastatic castration resistant prostate cancers (mCRPC) with DNA damage repair (DDR) alterations." Journal of Clinical Oncology 37, no. 15_suppl (2019): 5005. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.5005.

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5005 Background: We previously reported the antitumor activity of olaparib (400mg BID) against molecularly unselected mCRPC (TOPARP-A; Mateo et al NEJM 2015). We now report TOPARP-B, a phase II trial for patients with mCRPC preselected for putatively pathogenic DDR alterations. Methods: Patients with mCRPC progressing after ≥ 1 taxane chemotherapy underwent targeted sequencing of tumor biopsies and were deemed eligible when alterations (germline or somatic; mono- or bi-allelic) in any DDR gene were detected. Patients were randomized 1:1 under a “pick-the-winner” design to 400mg or 300mg of ola

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41

Jang, Yumi, Zeinab Elsayed, Rebeka Eki, et al. "Intrinsically disordered protein RBM14 plays a role in generation of RNA:DNA hybrids at double-strand break sites." Proceedings of the National Academy of Sciences 117, no. 10 (2020): 5329–38. http://dx.doi.org/10.1073/pnas.1913280117.

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Accumulating evidence suggests participation of RNA-binding proteins with intrinsically disordered domains (IDPs) in the DNA damage response (DDR). These IDPs form liquid compartments at DNA damage sites in a poly(ADP ribose) (PAR)-dependent manner. However, it is greatly unknown how the IDPs are involved in DDR. We have shown previously that one of the IDPs RBM14 is required for the canonical nonhomologous end joining (cNHEJ). Here we show that RBM14 is recruited to DNA damage sites in a PARP- and RNA polymerase II (RNAPII)-dependent manner. Both KU and RBM14 are required for RNAPII-dependent

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42

Ji, Jae-Hoon, Sunwoo Min, Sunyoung Chae, et al. "De novo phosphorylation of H2AX by WSTF regulates transcription-coupled homologous recombination repair." Nucleic Acids Research 47, no. 12 (2019): 6299–314. http://dx.doi.org/10.1093/nar/gkz309.

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Abstract Histone H2AX undergoes a phosphorylation switch from pTyr142 (H2AX-pY142) to pSer139 (γH2AX) in the DNA damage response (DDR); however, the functional role of H2AX-pY142 remains elusive. Here, we report a new layer of regulation involving transcription-coupled H2AX-pY142 in the DDR. We found that constitutive H2AX-pY142 generated by Williams-Beuren syndrome transcription factor (WSTF) interacts with RNA polymerase II (RNAPII) and is associated with RNAPII-mediated active transcription in proliferating cells. Also, removal of pre-existing H2AX-pY142 by ATM-dependent EYA1/3 phosphatases

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43

Schmidt, T. "'Unsere Geschichte'? Probleme der Holocaust-Darstellung unter DDR-Bedingungen: Peter Edel, Fred Wander, Jurek Becker (Teil II und Schluss)." Monatshefte XCVIII, no. 3 (2006): 403–25. http://dx.doi.org/10.3368/m.xcviii.3.403.

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44

Beer, Matthias. "Vertriebene und “Umsiedlerpolitik.” Integrationskonflikte in der deutschen Nachkriegsgesellschaft und die Assimilationsstrategien in der SBZ/DDR 1945-1961." Central European History 39, no. 1 (2006): 169–71. http://dx.doi.org/10.1017/s0008938906370069.

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Among forced population transfers in the twentieth century, the expulsion of the German population from East Central Europe at the end of World War II was remarkable. More than twelve million Germans were expelled from the eastern parts of the German Reich and some eastern European states. These refugees arrived in a defeated, occupied, destroyed, and divided country. Initially, the percentage of expelled persons in the Soviet Occupation Zone was much higher than in the western zones. With almost 4.5 million individuals, the expellees made up twenty-four percent of the total population in the

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45

Yamasaki, Nobuyuki. "Design Concept of Responsive Multithreaded Processor for Distributed Real-Time Control." Journal of Robotics and Mechatronics 16, no. 2 (2004): 194–99. http://dx.doi.org/10.20965/jrm.2004.p0194.

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This paper describes the design concept of Responsive MultiThreaded (RMT) Processor for distributed real-time control that controls various embedded systems including robots, home automation, factory automation, etc. RMT processor integrates an 8-way multithreaded processor (RMT processing unit) for real-time processing, four sets of Responsive Link II for real-time communication, and I/O peripherals including DDR SDRAM I/Fs, DMAC, PCI64, USB2.0, IEEE1394, PWM generators, pulse counters, etc., into an ASIC chip. System designers can use various on-chip functions easily by connecting required I

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46

Ramazanov, B. R., R. R. Khusnutdinov, A. R. Galembikova, P. D. Dunaev, and S. V. Boichuk. "Role of P53 protein in activation of atm- and parp-mediated dna damage repair (DDR) pathways induced by topoisomerase type II inhibitors." Kazanskiy meditsinskiy zhurnal 97, no. 2 (2016): 245–49. http://dx.doi.org/10.17750/kmj2015-245.

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47

Walz-Jung, H., I. Krämer, and W. Kamin. "Aerosolcharakteristika ausgewählter Druckluftvernebler für Erwachsene in Simulationsmodellen und Verneblung von Salbutamol." Pneumologie 72, no. 12 (2018): 820–31. http://dx.doi.org/10.1055/a-0749-5520.

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Zusammenfassung Ziel Der Erfolg einer Inhalationstherapie wird durch Menge und Qualität des inhalierten Aerosols bestimmt. Die Auswahl eines Verneblers bedarf der Kenntnis der entsprechenden Aerosolcharakteristika. Methoden Die Aerosolperformance von 9 marktüblichen Druckluftverneblern wurde in vitro in 2 Simulationsmodellen geprüft. Salbutamol (Sultanol forte® Fertiginhalat 2,5 mg/2,5 ml; GSK) wurde über 4 Minuten vernebelt. Die Outputparameter wurden mit dem Atemzugsimulator PARI Compas II (Erwachsenenmanöver nach Ph.Eur.9.0; n = 5/6 Verneblungen) und die aerodynamische Partikelgrößenverteil

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Fennell, Dean A., Jason Francis Lester, Sarah Danson, et al. "A randomized phase II trial of olaparib maintenance versus placebo monotherapy in patients with chemosensitive advanced non-small cell lung cancer." Journal of Clinical Oncology 38, no. 15_suppl (2020): e21649-e21649. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e21649.

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e21649 Background: Impaired DNA damage response (DDR) is a common feature of cancer, however therapeutic exploitation has been limited to cancers harbouring somatic inactivation of BRCA1/2 which causes homologous recombination deficiency (HRD). We hypothesized that patients (pts) with metastatic non-small cell lung cancer responding to platinum doublet based chemotherapy, might enrich for impaired DDR encompassing HRD, rendering these tumours more sensitive to inhibition of poly-ADP ribose polymerase (PARP) inhibition by olaparib. Methods: PIN was a multicentre double-blind placebo controlled

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ali, azka, David L. DeRemer, Ji-Hyun Lee, et al. "Phase II trial of the PARP inhibitor, niraparib, in BAP1 and other DNA damage response (DDR) pathway deficient neoplasms (NCT03207347)." Journal of Clinical Oncology 38, no. 15_suppl (2020): e22061-e22061. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e22061.

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e22061 Background: BRCA-associated protein-1 (BAP1) is a ubiquitin ligase associated with regulating cell cycle, cell proliferation, DNA damage pathway, and cell death. It also acts as a tumor suppressor gene as seen in hereditary cancer syndrome associated with germline mutations in BAP1. Preclinical studies have shown that PARP-inhibitor treatment of BAP1 mutant cell lines demonstrated significant synthetic lethality, independent of underlying BRCA status suggesting this mutation confers a BRCA-like phenotype. BAP1 is mutated, leading to a loss of functional protein, in up to 30% of several

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Chiorean, E. Gabriela, Katherine A. Guthrie, Philip Agop Philip, et al. "Randomized phase II study of second-line modified FOLFIRI with PARP inhibitor ABT-888 (Veliparib) (NSC-737664) versus FOLFIRI in metastatic pancreatic cancer (mPC): SWOG S1513." Journal of Clinical Oncology 37, no. 15_suppl (2019): 4014. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.4014.

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4014 Background: PC is characterized by DNA Damage Repair (DDR) deficiencies, including in BRCA1/2, ATM, and FANC genes. Given preclinical synergism between veliparib with irinotecan, safety and preliminary efficacy, we designed a randomized phase II study of mFOLFIRI (no 5-FU bolus) + veliparib vs FOLFIRI alone for 2nd line mPC patients (pts). Methods: Eligible pts had mPC, adequate organ function, ECOG PS 0-1, and 1 prior non-irinotecan systemic therapy.143 pts were to be randomized (1:1) to veliparib vs control. Primary endpoint was overall survival (OS). All pts had blood and tumor biopsie

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