Journal articles on the topic 'DCas9-VPR'
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Böhm, Sybille, Victoria Splith, Lisa Maria Riedmayr, René Dominik Rötzer, Gilles Gasparoni, Karl J. V. Nordström, Johanna Elisabeth Wagner, et al. "A gene therapy for inherited blindness using dCas9-VPR–mediated transcriptional activation." Science Advances 6, no. 34 (August 2020): eaba5614. http://dx.doi.org/10.1126/sciadv.aba5614.
Full textSchüller, Andreas, Lisa Wolansky, Harald Berger, Lena Studt, Agnieszka Gacek-Matthews, Michael Sulyok, and Joseph Strauss. "A novel fungal gene regulation system based on inducible VPR-dCas9 and nucleosome map-guided sgRNA positioning." Applied Microbiology and Biotechnology 104, no. 22 (October 2, 2020): 9801–22. http://dx.doi.org/10.1007/s00253-020-10900-9.
Full textBlanas, Athanasios, Lenneke A. M. Cornelissen, Maximilianos Kotsias, Joost C. van der Horst, Henri J. van de Vrugt, Hakan Kalay, Daniel I. R. Spencer, Rad P. Kozak, and Sandra J. van Vliet. "Transcriptional activation of fucosyltransferase (FUT) genes using the CRISPR-dCas9-VPR technology reveals potent N-glycome alterations in colorectal cancer cells." Glycobiology 29, no. 2 (October 22, 2018): 137–50. http://dx.doi.org/10.1093/glycob/cwy096.
Full textJosipović, Goran, Vanja Tadić, Marija Klasić, Vladimir Zanki, Ivona Bečeheli, Felicia Chung, Akram Ghantous, et al. "Antagonistic and synergistic epigenetic modulation using orthologous CRISPR/dCas9-based modular system." Nucleic Acids Research 47, no. 18 (August 14, 2019): 9637–57. http://dx.doi.org/10.1093/nar/gkz709.
Full textDing, Xiao, Lu Yu, Luo Chen, Yujie Li, Jinlun Zhang, Hanyan Sheng, Zhengwei Ren, et al. "Recent Progress and Future Prospect of CRISPR/Cas-Derived Transcription Activation (CRISPRa) System in Plants." Cells 11, no. 19 (September 28, 2022): 3045. http://dx.doi.org/10.3390/cells11193045.
Full textRiedmayr, Lisa M., Klara S. Hinrichsmeyer, Nina Karguth, Sybille Böhm, Victoria Splith, Stylianos Michalakis, and Elvir Becirovic. "dCas9-VPR-mediated transcriptional activation of functionally equivalent genes for gene therapy." Nature Protocols 17, no. 3 (February 7, 2022): 781–818. http://dx.doi.org/10.1038/s41596-021-00666-3.
Full textEwen-Campen, Ben, Donghui Yang-Zhou, Vitória R. Fernandes, Delfina P. González, Lu-Ping Liu, Rong Tao, Xingjie Ren, et al. "Optimized strategy for in vivo Cas9-activation in Drosophila." Proceedings of the National Academy of Sciences 114, no. 35 (August 14, 2017): 9409–14. http://dx.doi.org/10.1073/pnas.1707635114.
Full textLainšček, Duško, Lucija Kadunc, Mateja Manček Keber, Iva Hafner Bratkovič, Rok Romih, and Roman Jerala. "Delivery of an Artificial Transcription Regulator dCas9-VPR by Extracellular Vesicles for Therapeutic Gene Activation." ACS Synthetic Biology 7, no. 12 (December 4, 2018): 2715–25. http://dx.doi.org/10.1021/acssynbio.8b00192.
Full textBrancazio, S., C. Baez, L. Shan, T. H. Burdo, and R. Kaminski. "PP 4.12 – 00141 Enhancement of IL15/IL15RA signaling in immune cells using CRISPR-dCas9-VPR platform." Journal of Virus Eradication 8 (December 2022): 100220. http://dx.doi.org/10.1016/j.jve.2022.100220.
Full textHu, Wenbo, Xiaogang Wang, Sanyuan Ma, Zhangchuan Peng, Yang Cao, and Qingyou Xia. "CRISPR-Mediated Endogenous Activation of Fibroin Heavy Chain Gene Triggers Cellular Stress Responses in Bombyx mori Embryonic Cells." Insects 12, no. 6 (June 13, 2021): 552. http://dx.doi.org/10.3390/insects12060552.
Full textBui, Michelle, Elena Dalla Benetta, Yuemei Dong, Yunchong Zhao, Ting Yang, Ming Li, Igor A. Antoshechkin, et al. "CRISPR mediated transactivation in the human disease vector Aedes aegypti." PLOS Pathogens 19, no. 1 (January 19, 2023): e1010842. http://dx.doi.org/10.1371/journal.ppat.1010842.
Full textYilmaz, Ebru, Alisan Kayabolen, Semra Cemre Atalar, Buket Yigit, Burge Ulukan, Mujdat Zeybel, and Tugba Bagci-Onder. "Abstract 6255: CRISPRa-mediated induction of apoptosis in therapy-resistant glioblastoma cells via derepression of pro-apoptotic genes." Cancer Research 82, no. 12_Supplement (June 15, 2022): 6255. http://dx.doi.org/10.1158/1538-7445.am2022-6255.
Full textYang, Zhifen, and Francesco Marincola. "154 Context-dependent reversible modulation of cJUN expression by CAR T cells for cancer treatment." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (November 2021): A164. http://dx.doi.org/10.1136/jitc-2021-sitc2021.154.
Full textYang, Zhifen, Maggie Bobbins, Hana Choi, Ofir Stefanson, Jin Yang, Khristina Magallanes, Bing Wang, Lei Stanley Qi, and Francesco Marincola. "765 Contextual secretion of nanoscale interleukin (IL)-12 by CAR T cells for the treatment of cancer." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (November 2020): A813. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0765.
Full textYang, Zhifen, and Francesco Marincola. "153 Nanoscale, antigen-dependent, IL-12 delivery by CAR T cells plus PD-L1 blockade for cancer treatment." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (November 2021): A162—A163. http://dx.doi.org/10.1136/jitc-2021-sitc2021.153.
Full textGuo, Jimmy A., Jennifer Su, Ananya Jambhale, Julien Dilly, Connor J. Hennessey, Carina Shiau, Patrick Yu, et al. "Abstract A052: Systematic dissection of transcriptional states in pancreatic cancer." Cancer Research 82, no. 22_Supplement (November 15, 2022): A052. http://dx.doi.org/10.1158/1538-7445.panca22-a052.
Full textHwang, William L., Jennifer Su, Jimmy A. Guo, Carina Shiau, Jaimie L. Barth, Hannah I. Hoffman, Prajan Divakar, et al. "Abstract C052: Identifying mediators of perineural invasion in pancreatic cancer using spatial transcriptomics." Cancer Research 82, no. 22_Supplement (November 15, 2022): C052. http://dx.doi.org/10.1158/1538-7445.panca22-c052.
Full textOrtega-Yáñez, Andrea, Samantha Cruz-Ruiz, Martha Vázquez, and Mario Zurita. "Different transcriptional responses by the CRISPRa system in distinct types of heterochromatin in Drosophila melanogaster." Scientific Reports 12, no. 1 (July 9, 2022). http://dx.doi.org/10.1038/s41598-022-15944-7.
Full textBergenholm, David, Yasaman Dabirian, Raphael Ferreira, Verena Siewers, Florian David, and Jens Nielsen. "Rational gRNA design based on transcription factor binding data." Synthetic Biology, July 27, 2021. http://dx.doi.org/10.1093/synbio/ysab014.
Full textKlinnert, Sarah, Alex Chemnitzer, Peter Rusert, and Karin J. Metzner. "Systematic HIV-1 promoter targeting with CRISPR/dCas9-VPR reveals optimal region for activation of the latent provirus." Journal of General Virology 103, no. 6 (June 7, 2022). http://dx.doi.org/10.1099/jgv.0.001754.
Full textKarbassi, Elaheh, Alessandro Bertero, Shin Kadota, Paul Fields, Lil Pabon, Hans Reinecke, Stephen Hauschka, and Charles E. Murry. "Abstract 352: Optimization of a CRISPR Activation Human Pluripotent Stem Cell Line for Screening of Candidate Regulators of Cardiomyocyte Maturation." Circulation Research 127, Suppl_1 (July 31, 2020). http://dx.doi.org/10.1161/res.127.suppl_1.352.
Full textMózsik, László, Mirthe Hoekzema, Niels A. W. de Kok, Roel A. L. Bovenberg, Yvonne Nygård, and Arnold J. M. Driessen. "CRISPR-based transcriptional activation tool for silent genes in filamentous fungi." Scientific Reports 11, no. 1 (January 13, 2021). http://dx.doi.org/10.1038/s41598-020-80864-3.
Full textCui, Xuelian, Chao Zhang, Zhifang Xu, Shuaibin Wang, Xin Li, Erica Stringer-Reasor, Sejong Bae, et al. "Dual CRISPR interference and activation for targeted reactivation of X-linked endogenous FOXP3 in human breast cancer cells." Molecular Cancer 21, no. 1 (February 7, 2022). http://dx.doi.org/10.1186/s12943-021-01472-x.
Full textMijakovac, Anika, Julija Jurić, Wendy M. Kohrt, Jasminka Krištić, Domagoj Kifer, Kathleen M. Gavin, Karlo Miškec, et al. "Effects of Estradiol on Immunoglobulin G Glycosylation: Mapping of the Downstream Signaling Mechanism." Frontiers in Immunology 12 (May 25, 2021). http://dx.doi.org/10.3389/fimmu.2021.680227.
Full textPakalniškytė, Dalia, Tanja Schönberger, Benjamin Strobel, Birgit Stierstorfer, Thorsten Lamla, Michael Schuler, and Martin Lenter. "Rosa26-LSL-dCas9-VPR: a versatile mouse model for tissue specific and simultaneous activation of multiple genes for drug discovery." Scientific Reports 12, no. 1 (November 10, 2022). http://dx.doi.org/10.1038/s41598-022-23127-7.
Full textYang, Jiangeng, An Xia, Huajie Zhang, Qi Liu, Hongke You, Daoyuan Ding, Yonghua Yin, and Bo Wen. "Up-Regulating ERIC by CRISPR-dCas9-VPR Inhibits Cell Proliferation and Invasion and Promotes Apoptosis in Human Bladder Cancer." Frontiers in Molecular Biosciences 8 (March 29, 2021). http://dx.doi.org/10.3389/fmolb.2021.654718.
Full textGarcia-Perez, Elena, Borja Diego-Martin, Alfredo Quijano-Rubio, Elena Moreno-Giménez, Sara Selma, Diego Orzaez, and Marta Vazquez-Vilar. "A copper switch for inducing CRISPR/Cas9-based transcriptional activation tightly regulates gene expression in Nicotiana benthamiana." BMC Biotechnology 22, no. 1 (March 24, 2022). http://dx.doi.org/10.1186/s12896-022-00741-x.
Full textSchoger, Eric, Lavanya M. Iyer, Claudia Noack, Cheila Rocha, Mareike Jassyk, Orr Shomroni, Gabriela Salinas, and Laura C. Zelarayan. "Abstract 498: Krueppel-like Factor 15 Modulation: A Crispr-based Re-establishment of Homeostatic Transcription in Diseased Mouse and Human Cardiomyocytes." Circulation Research 127, Suppl_1 (July 31, 2020). http://dx.doi.org/10.1161/res.127.suppl_1.498.
Full textSchoger, Eric, Kim Rosa, Cheila Rocha, Mareike Jassyk, Shirin Doroudgar, Oliver Mueller, Lukas Cyganek, Wolfram H. Zimmermann, and Laura C. Zelarayan. "Abstract MP217: Nuclease-deficient Cas9 Transcription Factors Restore Krueppel-like Factor 15 Expression In Stressed Mouse And Human Cardiomyocytes." Circulation Research 129, Suppl_1 (September 3, 2021). http://dx.doi.org/10.1161/res.129.suppl_1.mp217.
Full textSchoger, E., L. Argyriou, W. H. Zimmermann, L. Cyganek, and L. C. Zelarayan. "Cutting-free application of CRISPR-mediated endogenous gene activation in human induced pluripotent stem cell derived cardiomyocytes and engineered human myocardium." European Heart Journal 42, Supplement_1 (October 1, 2021). http://dx.doi.org/10.1093/eurheartj/ehab724.3272.
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