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Muylwyk, Quirien. "Evaluation of six methods to estimate Giardia inactivation, a comparison with respect to chemical requirements, DBP formation, and DBP-related health risks." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ29393.pdf.
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Ryan, Brendan J. "The microbial degradation of the DDT metabolite dichlorobenzophenone (DBP)." Thesis, University of Canterbury. Microbiology, 1995. http://hdl.handle.net/10092/8554.
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Soil samples which had been previously exposed to chlorinated aromatics were screened for ability to degrade dichlorobenzophenone (DBP). Of the samples tested soil from the Dow Elanco Agricultural Farm and soil from the AgResearch Winchmore Research Station showed apparent degradative capabilities. Degradation was not sustainable in these soil samples and a time scale study showed DBP was stable in soil over a 24 week period. Samples from Winchmore were further used to establish enrichment cultures capable of degrading DBP and its non-chlorinated analogue benzophenone (BP) through selection pressure. BP proved to be readily degraded but
DBP degradation was only achieved after fungal suppressants were used. Degradation of DBP was enhanced with the addition of yeast extract and sodium salicylate to the enrichment cultures. Degradation of DBP was confirmed by capillary gas chromatography and the detection of the metabolite p-chlorophenyl acetic acid by gas chromatography-mass spectroscopy and thin layer chromatography. The enrichment cultures established on DBP also extensively degraded BP, p-chlorobenzophenone and p-chlorobenzoic acid. When inoculated back into soil, the enrichment cultures degradative capabilities were significantly reduced due to competition from other organisms, availability of alternative carbon sources and the bioavailability of DBP due to binding to soil particles.
Two organisms capable of degrading BP as sole carbon source were isolated and identified as a Rhodococcus spp. and a Streptomyces spp. BP degradative capabilities were not maintained by these organisms and lost when subculturing on nutrient media
Three presumptive DBP degraders were isolated and presumptively identified as two separate Streptomyces spp. and a Pseudomonas vesicularis. Of the three none were able to degrade DBP as sole carbon source in liquid culture although the P. vesicularis was able to co-metabolise DBP with the addition of yeast extract and sodium salicylate.
Preliminary genetical studies of the P. vesicularis isolated were carried out.
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Yang, Xin. "DBP formation from chlorination of water containing ammonia, bromide and organic nitrogen /." View abstract or full-text, 2004. http://library.ust.hk/cgi/db/thesis.pl?CIVL%202004%20YANG.
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Thesis (M. Phil.)--Hong Kong University of Science and Technology, 2004.Includes bibliographical references (leaves 100-118). Also available in electronic version. Access restricted to campus users.
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Cardona, Jaramillo Luis Ignacio. "Le logiciel EfiCoS dans un contexte de dimensionnement basé sur la performance (DBP)." [S.l. : s.n.], 2008.
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Mendiburu, Díaz Henry A. "Diseño de un neurocontrolador dinámico (DBP) aplicado a un reactor químico continuo (CSTR)." Master's thesis, Pontificia Universidad Católica del Perú, 2005. http://tesis.pucp.edu.pe/repositorio/handle/123456789/138.
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La presente tesis se compone de cuatro capítulos: en el primer capítulo se plantea los objetivos de la esta investigación y se realiza una recopilación de información referente a investigaciones relacionadas con el control y la automatización de reactores químicos CSTR. En el segundo capítulo realiza una introducción teórica sobre el reactor tanque agitado continuo, así mismo se desarrolla el modelo matemático de un reactor químico de este tipo, el cual servirá para la simulación del sistema a controlar. En el tercer capítulo se lleva a cabo el desarrollo de los criterios de diseño y parámetros de sintonización de los diversos controladores implementados para aplicarlos al reactor. En el cuarto capítulo se presentan las simulaciones del sistema sometido a la acción de control de los diversos controladores, para luego elaborar un análisis de la performance de cada uno, y finalmente establecer la superioridad del neurocontrolador dinámico frente a otros controladores.Tesis
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Lourenço, Ana Carolina dos Santos. "Influência de diferentes veículos oleosos na toxicidade reprodutiva do Di-Butil Ftalato (DBP)." reponame:Repositório Institucional da UFPR, 2011. http://hdl.handle.net/1884/26189.
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Resumo: Alguns esteres de ftalatos podem alterar o desenvolvimento do trato reprodutivo masculino quando administrados a ratos in utero, induzindo efeitos similares aos disturbios que fazem parte da Sindrome da Disgenesia Testicular humana (TDS). A incidencia e severidade das respostas toxicas induzidas pelos ftalatos durante o periodo pre-natal se mostram significativamente variaveis entre diferentes laboratorios, o que poderia ser explicado por diversos fatores, incluindo linhagem de ratos, condicoes laboratoriais, dieta e tipo de veiculo oleoso utilizado. Assim, tem sido proposto que a suplementacao com oleos contendo altos niveis de acidos graxos Omega-3 (encontrados em oleo de peixe e canola) poderia reverter alguns dos efeitos reprodutivos adversos induzidos por ftalatos. Para determinar o possivel efeito dos veiculos oleosos na toxicidade dos ftalatos, ratas Wistar prenhes foram tratadas com di-butil ftalato (DBP) diluido em tres diferentes veiculos: oleo de milho, canola ou peixe. Tres grupos controle receberam somente veiculos, e tres grupos foram expostos a 500 mg/kg/dia, diluido em oleo de milho, canola ou peixe. O tratamento se deu via oral (gavage) dos dias 13 a 20 de gestacao e o volume administrado foi de 5 mL/kg/dia para todos os grupos. As femeas foram pesadas durante a gestacao e eutanasiadas no dia 20 de gestacao, duas horas apos a ultima administracao de DBP ou veiculos. A distancia anogenital (AGD) foi medida em fetos machos e femeas. Apos serem decapitados, tres fetos machos por ninhada tiveram seus testiculos coletados para imunohistoquimica, histologia e dosagem de testosterona testicular e de lipideos. A exposicao ao DBP reduziu significativamente os niveis de testosterona testicular e a distancia anogenital em fetos machos, independente do veiculo utilizado. Foi observado um aumento no percentual de cordoes seminiferos contendo gonocitos multinucleados (MNGs) e no diametro dos cordoes seminiferos em grupos expostos ao DBP, sem haver diferenca entre esses grupos. No entanto, nao houve diferenca significativa entre o grupo tratado com DBP diluido em oleo de canola e seu respectivo controle em relacao a presenca de MNGs. Alem disso, o grupo tratado com DBP diluido em oleo de peixe nao diferiu do seu grupo controle na analise de diametro de cordoes seminiferos. Para avaliacao dos clusters de celulas de Leydig, foi realizada imunohistoquimica com anti-3ƒÀ-HSD. Houve significativa diminuicao na contribuicao de clusters pequenos para a area total de clusters em todos os grupos expostos ao DBP. No entanto, nao houve influencia do veiculo oleoso nesse parametro. O perfil lipidico determinado por HPLC indicou que a administracao dos oleos de peixe e canola foi capaz de aumentar a quantidade de acidos graxos Omega-3 no testiculo fetal. No entanto, a incorporacao de Omega-3 foi reduzida em grupos tratados com DBP, quando comparados aos controles. Juntos, esses resultados indicam que mesmo os oleos de canola e peixe tendo sido incapazes de alterar a deficiencia de testosterona induzida por DBP ou a diminuicao da distancia anogenital, mudancas sutis na histologia testicular puderam ser observadas. Os efeitos de uma suplementacao mais prolongada com oleos ricos em Omega-3 ainda precisam ser determinados.
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Cardona, Jaramillo Luis Ignacio. "Le logiciel EfiCoS dans un contexte de dimensionnement basé sur la performance (DBP)." Mémoire, Université de Sherbrooke, 2008. http://savoirs.usherbrooke.ca/handle/11143/1419.
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Aujourd'hui, les analyses sismiques sont de plus en plus dirigées vers un dimensionnement basé sur la performance (DBP). En effet, il y a un consensus que le DBP deviendra la méthode à employer dans un futur proche en ce qui concerne le dimensionnement parasismique des structures. Donc, un outil est nécessaire pour obtenir l'évolution, l'évaluation et la localisation de l'endommagement avec precision. Dans cette idée, le présent projet de recherche avait pour but d'étudier la performance du logiciel EFiCoS face à la prédiction de la réponse globale (force-déplacement en tête) et locale d'une série de 21 poteaux testés à l'Université de Sherbrooke et de proposer une matrice d'endommagement qui permet de relier l'endommagement prédit par EFiCoS, aux états limites associés aux niveaux de performance décrits par la plus part des comités les plus connus (ATC 40, FEMA, SEAOC entre autres). Des nombreuses améliorations ont été apportées au code source d'EFiCoS afin d'obtenir une meilleure performance de celui-ci. Parmi les améliorations les plus significatives se trouve l'insertion de deux nouvelles lois de comportement pour l'acier d'armature. La première de ces lois est celle développée par Dodd et Restrepo-Posada (1995). La deuxième loi est une version simplifiée de cette dernière qui a été développée au cours de ce projet de recherche. Plusieurs outils informatiques ont été créés dans le cadre de cette recherche. Le plus pertinent est l'outil EFiLIC, lequel est un post-processeur destiné à traiter les données de sortie d'EFiCoS. Les résultats d'analyse obtenus avec EFiCoS ont démontré la capacité de celui-ci à prédire adéquatement le comportement des poteaux étudiés. Ceci fait d'EFiCoS un outil pertinent pour le dimensionnement basé sur la performance (DBP) Finalement, grâce aux prédictions d'endommagement d'EFiCoS, des cartes d'endommagement ont été obtenues tant pour le béton confiné que non confiné. Ces cartes ont été élaborées en termes de déplacement relatif ("drift") mais aussi en termes de ductilité structurale de déplacement. De cette façon, les cartes développées permettent de faire une lien directe entre l'endommagement prédit par EFiCoS et les niveaux de performances établis.
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Pollett, Jonathan Barclay. "The role of the PAR proteins, HLF and DBP, in transactivation and liver differentiation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ28247.pdf.
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Fischer, William D. "Enhancing network communication in NPSNET-V virtual Environments using XML: Described dynamic Behavior (DBP) Protocols/." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2001. http://handle.dtic.mil/100.2/ADA397348.
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Thesis (M.S. in Computer Science)-- Naval Postgraduate School, Sept. 2001."September 2001." Thesis advisor(s)McGregor, Don ; Brutzman, Don. Includes bibliographical references (p. 127-128). Also Available online.
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Seubert, Niko [Verfasser], and Andreas [Akademischer Betreuer] Kronenburg. "LES-PDF modelling of nucleation and growth of DBP droplets / Niko Seubert ; Betreuer: Andreas Kronenburg." Stuttgart : Universitätsbibliothek der Universität Stuttgart, 2019. http://d-nb.info/1191182614/34.
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LAING, CHRISTOPHER JAMES. "Comparative Studies on Plasma Vitamin D Binding Protein." University of Sydney, 2000. http://hdl.handle.net/2123/359.
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The plasma vitamin D binding protein (DBP) is an a-glycoprotein, synthesised and secreted by the liver, which binds specifically vitamin D and its metabolites. The DBP molecule, has a single high affinity binding site for its ligands, and is present in blood in concentrations about 1000-fold greater than the sum of all its vitamin D ligands. Previous studies have not found any change in the concentration of DBP related to various derangements in mineral homeostasis. Therefore the general view is that DBP has a passive role in the physiology of vitamin D and its metabolites, and simply acts to solubilise and transport these hydrophobic ligands in the aqueous extracellular fluid. However, differences which have been described in its affinity for various vitamin D metabolites suggest that there have been evolutionary influences on the properties of this protein. Furthermore, plasma DBP concentration has been found to change in response to a number of physiological factors, such as changing sex steroid hormone secretion. The aim of the studies presented in this thesis was to investigate variation in the plasma concentration of the DBP in a range of vertebrate species, and in response to a variety of physiological factors. The results suggest that DBP may have an active role in regulating the bioavailability, and hence the utilisation and metabolism of its ligands. DBP concentration has traditionally been measured using immunological techniques. These techniques, although fast and simple, have a number of draw-backs which can be overcome by the use of assays which rely upon functional aspects of the DBP. A saturation binding assay was modified from those described previously. Using this technique, it was found that both the circulating concentration of the DBP and its affinity for 25-hydroxyvitamin D3 (25(OH)D3) varied significantly among a wide range of species of reptiles and birds. This variation did not reflect phylogenetic relationships among the study species, suggesting that the variation was more likely to be the result of selective pressure in response to individual ecological or physiological circumstance, rather than to random mutation. In support of this, both the plasma concentration of DBP, and its affinity for 25(OH)D3 were significantly associated with a number of ecological factors which might be considered to have some significance to vitamin D and calcium homeostasis. In addition, comparative binding data suggests that the ability of the DBP to bind 25-hydroxyvitamin D2 with equal affinity to 25(OH)D3 is an evolutionary innovation of mammalian vertebrates. In order to extend the idea of genetic variation in the concentration and affinity of plasma DBP, two strains of broiler (meat-type) chickens were studied. It was found that both the concentration and the affinity of plasma DBP for 25(OH)D3 was characteristic for each strain, emphasising the sensitivity of DBP to genetic variation. A number of factors have been found to modulate the genetically determined plasma concentration of DBP. Deficiencies of dietary protein and dietary energy, and variation in concentrations of sex steroids were found to affect the circulating concentration of DBP. However, species differences were still apparent, suggesting that the sensitivity of DBP to these physiological modifiers may have developed independently in different species, and may be secondary to genetic determinants of DBP properties. The plasma DBP concentration and specific binding affinity both determine the availability of its ligands for cellular uptake. It is likely that this process is complex, and involves a combination of protein mediated and non-mediated uptake events. This makes DBP a potentially important determinant of the biological actions of its ligands. The studies in this thesis have produced two main lines of argument supporting an active role for DBP in the regulation of vitamin D metabolism and utilisation. The first is that genetic variation in the properties of plasma DBP appears to be genetically determined, and is selected for, both at the between-species, and the within-species level, than it is to random mutation. Secondly, the ability of physiological and environmental factors to modify the circulating concentration of DBP suggests that this protein is responsive to homeostatic processes. It is proposed that DBP is an active regulator of the physiological economy of vitamin D and its metabolites by being itself regulated by a number of genetic and non-genetic factors.
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Less, John Ryan. "Comparison of Natural Organic Matter (NOM) Removal Processes on Disinfection Byproduct (DBP) Formation During Drinking Water Treatment." University of Akron / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=akron1293217404.
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Castelló, Llopis María José. "Identificación y caracterización de la familia de factores DBP, nuevos reguladores de la expresión génica en plantas." Doctoral thesis, Universitat Politècnica de València, 2009. http://hdl.handle.net/10251/6363.
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El factor de transcripción DBP1 de Nicotiana tabacum, es el primer miembro de una nueva familia de reguladores transcripcionales que poseen, además de capacidad de unión al ADN, actividad proteín-fosfatasa de tipo 2C. En este trabajo hemos abordado la caracterización funcional del factor regulador DBP1, determinando que su capacidad de unión al ADN reside en el motivo DNC, el cual se localiza en la región N-terminal de la proteína y está conservado entre las proteínas DBP de diferentes plantas mono y dicotiledóneas. Así mismo hemos llevado a cabo una búsqueda de factores proteicos que interaccionan con DBP1. Así, la isoforma G de la proteína 14-3-3 se presenta como el primer interactor de DBP1, comprometiendo en dicha interacción una zona del dominio N-terminal adyacente al motivo DNC. Mediante expresión transitoria en N. benthamiana hemos podido comprobar que la isoforma G de la 14-3-3 es capaz de promover la exclusión nuclear de DBP1, modificando la distribución núcleo-citoplasma que presenta en condiciones basales y participando así de manera indirecta en la regulación de genes diana de DBP1 como CEVI1.
De los cuatro homólogos estructurales de DBP1 identificados en A. thaliana, AtDBP1 es el representante estructuralmente más semejante a DBP1 de tabaco. AtDBP1 mantiene la capacidad de unirse al ADN así como la actividad fosfatasa 2C característica de esta familia, y es capaz de interaccionar a través de su región N-terminal con la proteína GRF6, homóloga a la 14-3-3 G de tabaco. Con el objetivo de identificar dianas de AtDBP1 tanto a nivel transcripcional como post-transcripcional para así averiguar los procesos biológicos en los que están implicados estos factores, se ha realizado un análisis proteómico comparativo entre plantas Col-0 y mutantes atdbp1 que ha puesto de manifiesto una baja acumulación de una de las isoformas del factor de inicio de la traducción 4E, eIF(iso)4E, en el mutante atdbp1.Castelló Llopis, MJ. (2008). Identificación y caracterización de la familia de factores DBP, nuevos reguladores de la expresión génica en plantas [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/6363
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Ackerson, Nana Osei Bonsu. "Iopamidol as a Precursor to DBP Formation in Drinking Water as a Function of Natural Matter and Bromide." University of Akron / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=akron1499332403354556.
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Ylianttila, M. (Mari). "Structure-function studies of the peroxisomal multifunctional enzyme type 2 (MFE-2)." Doctoral thesis, University of Oulu, 2005. http://urn.fi/urn:isbn:9514278968.
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Abstract
Multifunctional enzyme type 2 (MFE-2) catalyses the second and the third reactions in the eukaryotic peroxisomal β-oxidation cycle, which degrades fatty acids by removing a two-carbon unit per each cycle. In addition to the 2-enoyl-CoA hydratase 2 and (3R)-hydroxyacyl-CoA dehydrogenase activities, mammalian MFE-2 has also a sterol carrier protein type 2-like (SCP-2L) domain. In contrast, yeast MFE-2 has two (3R)-hydroxyacyl-CoA dehydrogenases, one 2-enoyl-CoA hydratase 2 and no SCP-2L domain.
The physiological roles of yeast (3R)-hydroxyacyl-CoA dehydrogenases (A and B) were tested by inactivating them in turn by site-directed mutagenesis and testing the complementation of Saccharomyces cerevisiae fox-2 cells (devoid of endogenous MFE-2) with mutated variants of Sc MFE-2. Growth rates were lower for fox-2 cells expressing only a single functional domain than for those expressing the Sc MFE-2. Kinetic studies with purified Candida tropicalis MFE-2 and its mutated variants show that dehydrogenase A catalyzes the reaction more efficiently with the medium- and long-chain substrates than dehydrogenase B, which in turn is the only one active with the short chain fatty acids.
The structural basis of the substrate specificity difference of these two dehydrogenases was solved by X-ray crystallography together with docking studies. Protein engineering was used to produce a stabile, homogenous recombinant protein of C. tropicalis dehydrogenases in one polypeptide. The heterodimeric structure contains the typical fold of the short-chain alcohol dehydrogenase/reductase (SDR) family. Docking studies suggest that dehydrogenase A binds medium chain-length substrates as bended, whereas short chain substrates are dislocated, because they do not reach the hydrophobic contacts needed for anchoring the substrate to the active site, but are instead attracted by L44. Dehydrogenase B has a more shallow binding pocket and thus locates the short chain-length substrates correctly for catalysis. Thus the data provide clues for structural basis of the different substrate specificities.
The molecular basis of the patient mutations of MFE-2 (DBP deficiency) was studied using the recently solved crystal structures of rat (3R)-hydroxyacyl-CoA dehydrogenase, human 2-enoyl-CoA hydratase and SCP-2L. The predicted effect of the mutations on protein structure could in several cases be explained, and these data supported the conclusion that a genotype-phenotype correlation exists for DBP deficiency.
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Bales, Dustin William. "Optimization of an Advanced Water Treatment Plant: Bromate Control and Biofiltration Improvement." Scholar Commons, 2012. http://scholarcommons.usf.edu/etd/4286.
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The David L. Tippin Water Treatment Facility (DLTWTF) serving the city of Tampa, Florida is an advanced drinking water treatment facility consisting of coagulation/flocculation, ozonation, granular activated carbon biofiltration, and disinfection by chloramine. New regulations and the recent economic crisis pushed the facility to investigate methods to decrease costs and meet regulatory requirements easier.
The two major issues identified as priorities for investigation were the optimization of the biofiltration system and the use of a novel process to reduce the formation of bromate during ozonation.
Optimization of the biofiltration system is needed to remove more of the assorted particles that cause biofilms, nitrification in the distribution system, and high chloramine demand. Previous work improved the removal of particles that cause biofilms and nitrification, but was not able address the removal of particles that cause high chloramine demand to a satisfactory degree. Possible factors affecting this high chloramine decay were identified and evaluated at the pilot scale, including filter depth, chloramination of filter backwash water, media material, and nutrient addition. Non-chlorinated backwash water reduced chloramine demand by approximately 30% for GAC filters, and by approximately 50% for anthracite. Generally, anthracite performed slightly worse than GAC. Nutrient addition showed no effect. Filter depth improved chloramine decay, but not significantly enough to warrant the increased material required
Bromate control is necessary to prevent the formation of bromate, a regulated carcinogen. Traditional bromate control methods use pH depression. While effective, at the DLTWTF, this forces the increased use of more expensive caustic soda over lime for raising the pH of process water. A novel process known as the chlorine-ammonia process was investigated at the bench scale to identify the ideal ratio of chlorine and ammonia to decrease the formation of bromate to ensure regulatory compliance and allow greater use of lime to decrease costs. The best ratio in this study is 0.45 mg/L NH3 to 0.75 mg/L Cl2 which produced 1.09 ppb bromate at a CT of 6.8 min*mg/L, representing a 84% improvement over the control.
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Golden, Nicholas Scott. "THE EFFECT OF NATURAL ORGANIC MATTER VARIATION AND PIPE DEPOSIT MATERIAL ON DISINFECTION BYPRODUCT FORMATION." University of Akron / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=akron1125003937.
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Wannamaker, Christopher L. "Chlorine Decay and Disinfection By-product Formation of Dissolved Organic Carbon Fractions with Goethite." University of Akron / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=akron1208476198.
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Machek, Edward Joseph Jr. "Iopamidol as a Precursor to Iodinated Disinfection Byproduct (DBP) Formation as a Function of NOM concentration, pH, and Chlorinated Oxidants." University of Akron / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=akron1439045967.
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Wang, Fang. "Chlorine Contribution to Quantitative Structure and Activity Relationship Models of Disinfection By-Products' Quantum Chemical Descriptors and Toxicities." FIU Digital Commons, 2009. http://digitalcommons.fiu.edu/etd/174.
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Quantitative Structure-Activity Relationship (QSAR) has been applied extensively in predicting toxicity of Disinfection By-Products (DBPs) in drinking water. Among many toxicological properties, acute and chronic toxicities of DBPs have been widely used in health risk assessment of DBPs. These toxicities are correlated with molecular properties, which are usually correlated with molecular descriptors. The primary goals of this thesis are: 1) to investigate the effects of molecular descriptors (e.g., chlorine number) on molecular properties such as energy of the lowest unoccupied molecular orbital (ELUMO) via QSAR modelling and analysis; 2) to validate the models by using internal and external cross-validation techniques; 3) to quantify the model uncertainties through Taylor and Monte Carlo Simulation. One of the very important ways to predict molecular properties such as ELUMO is using QSAR analysis. In this study, number of chlorine (NCl) and number of carbon (NC) as well as energy of the highest occupied molecular orbital (EHOMO) are used as molecular descriptors. There are typically three approaches used in QSAR model development: 1) Linear or Multi-linear Regression (MLR); 2) Partial Least Squares (PLS); and 3) Principle Component Regression (PCR). In QSAR analysis, a very critical step is model validation after QSAR models are established and before applying them to toxicity prediction. The DBPs to be studied include five chemical classes: chlorinated alkanes, alkenes, and aromatics. In addition, validated QSARs are developed to describe the toxicity of selected groups (i.e., chloro-alkane and aromatic compounds with a nitro- or cyano group) of DBP chemicals to three types of organisms (e.g., Fish, T. pyriformis, and P.pyosphoreum) based on experimental toxicity data from the literature. The results show that: 1) QSAR models to predict molecular property built by MLR, PLS or PCR can be used either to select valid data points or to eliminate outliers; 2) The Leave-One-Out Cross-Validation procedure by itself is not enough to give a reliable representation of the predictive ability of the QSAR models, however, Leave-Many-Out/K-fold cross-validation and external validation can be applied together to achieve more reliable results; 3) ELUMO are shown to correlate highly with the NCl for several classes of DBPs; and 4) According to uncertainty analysis using Taylor method, the uncertainty of QSAR models is contributed mostly from NCl for all DBP classes.
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Rocha, Márcia Andrade da. "Identificação de polimorfismos do gene DBP (vitamin Dbinding protein) em pacientes com tuberculose pulmonar ativa no Estado do Rio de Janeiro." reponame:Repositório Institucional da FIOCRUZ, 2007. https://www.arca.fiocruz.br/handle/icict/14278.
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Previous issue date: 2007Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil
A tuberculose (TB) é a principal causa de morbi-mortalidade por doença infecciosa no mundo. Um terço da população mundial está infectada com o Mycobacterium tuberculosis (Mtb) e a cada ano ocorrem cerca de 9 milhões de novos casos com cerca de 2 milhões de mortes. Uma das principais perguntas ainda sem resposta na TB é o porquê de somente 1 em cada 10 indivíduos infectados desenvolvem esta doença. Existem três fatores de risco principais que contribuem no desenvolvimento desta infecção:i) o agente patogênico (principalmente seu grau de virulência), ii) fatores ambientais em que vive o hospedeiro e iii) o grau de susceptibilidade ao patógeno, vinculado a fatores genéticos. A associação destes três fatores determinam o grau de risco à infecção e adoecimento na tuberculose. Desta forma, este trabalho tem como objetivo identificar uma possível associação entre os polimorfismos do gene DBP codificador da proteína de transporte da vitamina D (VDBP) à susceptibilidade ou resistência ao Mtb. A VBDP é sintetizada no fígado e é uma proteína sérica multifuncional, cuja principal função é se ligar e transportar a VD até as células e tecidos alvo. Além disso, possui um importante papel na ativação de macrófagos (Gc- MAF), independente da sua ligação com a VD. Para realizar esse estudo, foram incluídos 160 pacientes com TB pulmonar HIV-1 negativos e 95 indivíduos controle. Dois polimorfismos no gene DBP localizados na posição 416 (HaeIII) e 420 (StyI) foram tipados Não observamos diferenças entre estes grupos em relação aos genótipos, apesar de encontrarmos valores próximos a significância para o HH (p=0,08; OR=1,6) e SS (p=0,06; OR=1,6), o que foi observado quando analisamos o fenótipo F/F (HS/HS, Asp/Thr-Asp/Thr) pode estar relacionado à susceptibilidade ao Mtb, uma vez que este fenótipo foi encontrado com maior frequência nos pacientes com TB do que nos indivíduos controle (p=0,004, OR=2,81). Nenhuma outra associação foi evidenciada em relação a outros fenótipo de VDBP. De modo interessante, quando indivíduos controles foram subdivididos em sadios (baixa exposição ao Mtb) e contactantes (alta exposição ao Mtb), vale salientar que esses dois grupos são compostos por indivíduos saudáveis, observamos que o fenótipo S/S (hS/hS, Glu/Thr \2013Glu/Thr) pode estar relacionado a resistência, pois os indivíduos sadios mostraram uma maior frequência deste fenótipo (p=0,01, OR=0,4). O presente estudo demonstrou, pela primeria vez, uma possível associação entre os polimorfismos no gene DBP nas posições 416 e 420 com TB, assim, a combinação destes genótipos e consequentes fenótipos poderá induzir uma forte associação com a susceptibilidade. Aspectos funcionais desta associação merecem mais estudos, bem como determinar o papel destes genótipos no controle intracelular do M. tuberculosis e os níveis de vitamina D em pacientes com tuberculose
The tuberculosis (TB) is the main cause of mortalit y infections diseases worldwide. One third of world population is infecte d with Mycobacterium tuberculosis (Mtb) and about 9 million new cases occur each year with 2 million deaths. One of the main questions of TB is why only 1 out of 10 infect ed people develop the disease. There are three important risk factors that contrib ute to the development of this infection: i) the pathogenic agent (its virulence), ii) the environment where the host lives and iii) his/her susceptibility to the pathogen. Th e association among these 3 factors determines the risk factor degree to infection and illness to TB. Thus, this study had the objective to identify possible association among DBP gene polymorphisms that codifies the vitamin D binding protein (VDBP) to susceptibil ity or resistance to TB. The VDBP is synthesized in the liver and it is a multifunctiona l protein, which the most important function is to bind and transport the Vitamin D (VD ) to the target cells and tissues. Besides, it has an important role on macrophages (G c-MAF), independently of its association with the VD. This study included patien ts with pulmonary tuberculosis, HIV- 1 negative and control individuals. We identified t wo polymorphisms on DBP gene localized in the 416 ( HaeIII ) and 420 ( StyI )) codons. We couldn’t observe differences in these two groups in relation to the DBP genotypes, in spite of, we almost found the significance value to HH (p=0.08; OR=1.6) and SS (p =0.06; OR=1.6). The FF phenotype (HS/HS, Asp/Thr-Asp/Thr) could be related to susceptibility to TB, since this phenotype was observed in higher frequency in our p ulmonary TB patients compared to the control group (p=0.004, OR=2.81). No more si gnificance was found when we analyzed, in the specific groups, the others VDBP p henotypes. In interesting way, the phenotypes S/S (hS/hS, Glu/Thr –Glu/Thr) could be r elated to resistence to TB, once we observed a higher frequency in the healthy group (low TB exposition) compared to the contact group (high TB exposition) and is worth saying that in both subgroups the subjects are healthy. For the first time this study demonstrated an association between the 416 and 420 polymorphisms on the DBP gene with susceptibility to TB. Further studies are necessary to evaluate the functinal asp ects of this association as well as to determine the role of this genotypes in combat the intracellular Mtb and also, to measure the levels of Vitamin D in each TB patient
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Silva, Roberta Bozi da. "Análise do potencial imunogênico de variantes polimórficas da proteína de ligação ao antígeno Duffy (DBP) do Plasmodium vivax em modelos murinos." Universidade Federal de Minas Gerais, 2013. http://hdl.handle.net/1843/BUOS-9AKHXB.
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Malaria is a parasitic disease that affects millions of people worldwide, and species of protozoa that cause human malaria, Plasmodium vivax is the species that has the highest worldwide distribution. In this species, so that the merozoite invades erythrocytes are required specific interactions involving proteins of the parasite and receptors present on the host cell surface, and this invasion mediated by the interaction between the binding protein to Duffy antigen (Duffy Binding Protein - PvDBP) and its receptor on the surface of Duffy positive erythrocytes. In endemic areas of Brazil, MT and PA polymorphisms were shown to be responsible for the vast majority of human infections, becoming interesting targets for vaccine in this study, which were cloned and expressed as recombinant proteins and also conjugated to recombinant adenoviruses, being used in immunization protocols prime/boost in mice. The results obtained showed that the polymorphisms are able to strongly stimulate the immune system, demonstrating that DBP of P. vivax is a promising vaccination target, with the adjuvant Montanide ISA 720 and human adenovirus type 5, promoting the production of high titers of functional antibodies. It was also verified a synergistic action between the two polymorphisms in the maintenance of antibody titers months after mice immunization.A malária é uma doença parasitária que afeta milhões de pessoas em todo o mundo, e das espécies de protozoários causadores da malária humana, o Plasmodium vivax é a espécie que apresenta maior distribuição mundial. Nesta espécie, para que o merozoíto invada o eritrócito são necessárias interações específicas envolvendo proteínas do parasito e receptores presentes na superfície da célula hospedeira, sendo essa invasão mediada pela interação entre a proteína de ligação ao antígeno Duffy (Duffy Binding Protein - PvDBP) e seu receptor na superfície dos eritrócitos Duffy-positivos. Na área endêmica brasileira, os polimorfismos MT e PA mostraram-se responsáveis pela grande maioria das infecções humanas, tormando-se alvos vacinais interessantes para este estudo, os quais foram clonados e expressados como proteínas recombinantes e também conjugados a adenovírus recombinantes, sendo utilizados em protocolos de imunização dose/reforço em camundongos. A análise dos resultados obtidos mostrou que os polimorfismos estudados são capazes de estimular o sistema imune fortemente, demonstrando que a DBP do P. vivax é um alvo vacinal promissor, juntamente com o adjuvante vacinal Montanide ISA 720 e adenovírus humano tipo 5, promovendo a produção de altos títulos de anticorpos funcionais. Foi possível verificar também uma ação sinérgica entre os dois polimorfismos estudados na manutenção dos títulos de anticorpos meses após a imunização dos camundongos.
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Skeriotis, Andrew Theodoros. "Fluorescence and UV Methods for Predicting Dissolved Organic Carbon and Disinfection By-Product Formation in Drinking Water." University of Akron / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=akron1321458958.
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Johnstone, David Weston. "Drinking Water Disinfection Byproduct Formation Assessment Using Natural Organic Matter Fractionation and Excitation Emission Matrices." University of Akron / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=akron1247802154.
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Killinger, Alexis. "Iodinated X-ray contrast media (ICM) as precursors to disinfection byproduct (DBP) formation and enhanced toxicity as a function of pH and chlorinated oxidant." University of Akron / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=akron1460375515.
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Santos, Talita de Mello [UNESP]. "Morfogênese da próstata de ratos expostos ao Di-n-Butil-Ftalato (DBP) no período gestacional e lactacional: expressão de proteínas regulatórias sobre a diferenciação glandular." Universidade Estadual Paulista (UNESP), 2015. http://hdl.handle.net/11449/144032.
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000868481.pdf: 1768402 bytes, checksum: f07378e2171ada5ea90dafd13bd75e47 (MD5)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Os ftalatos são ésteres utilizados na fabricação de plásticos transparentes empregados na indústria e são amplamente encontrados como substâncias contaminantes no meio ambiente, sendo o tipo mais encontrado, o Di-n-Butil-Ftalato (DBP). Diversos estudos têm mostrado efeitos antiandrogênicos do DBP em ratos expostos durante a vida fetal, refletindo em alterações morfofuncionais sobre órgãos reprodutivos. A morfogênese da próstata é um processo dependente de andrógeno resultante das interações entre mesênquima e epitélio, modulada por fatores de crescimento e algumas moléculas de sinalização. Dentre elas, estão as BMPs que controlam o desenvolvimento de vários tecidos e sofrem influência hormonal. O objetivo deste estudo foi avaliar os efeitos da exposição gestacional e lactacional ao DBP em duas doses (100 e 500mg/kg), sobre a morfogênese inicial e intermediária da próstata de ratos. Assim, fêmeas prenhes da linhagem Wistar foram divididas em 3 grupos experimentais (n=10): CN (controle negativo); DBP100 (DBP; 100 mg/kg) e DBP500 (DBP; 500 mg/kg). Os animais tratados foram expostos ao DBP do 15º dia de gestação (DG15) até o 21º dia pósnatal (DPN21) por gavagem, enquanto os animais CN receberam óleo de milho (veículo). Os animais da geração F1 foram eutanasiados por decapitação nos DPN1 e DPN21, e procedeuse a coleta do sangue para a análise sérica de testosterona. A parte pélvica da uretra (DPN1) e a próstata ventral (DPN21) foram submetidas às análises histológica e imuno-histoquímica para a detecção de AR (receptor de andrógeno), antígeno P63 e α-actina; enquanto que os níveis das proteínas: AR, BMP-4 e PCNA foram avaliados por Western Blot. No DPN1, houve redução na distância anogenital e nos níveis de testosterona nos animais tratados com DPB, e a reconstrução 3D mostrou redução nos números e comprimentos dos brotos no grupo DBP500. A imunomarcação para AR e α-actina foi...
Phthalate esters such as Di-n-butyl phthalate (DBP) are used in the manufacture of transparent plastics and they are widely found as contaminants in the environment. Previous studies have shown anti-androgens effects of DBP in rats exposed during fetal life, which presented morphological changes on the reproductive organs. Morphogenesis of the prostate is an androgen-dependent process that depends on interactions between mesenchymal and epithelial cells and it is modulated by growth factors and signaling molecules. Among these molecules, BMPs are important morphogenetic proteins, which are influenced by hormonal levels. These proteins have been implicated in the regulation of prostatic branching morphogenesis. The aim of this study was to evaluate the effects of gestational and lactational exposure to DBP in two doses (100 and 500 mg/kg b.w.) on the initial and intermediate morphogenesis in prostate of rats. Thus, pregnant female rats were divided into 3 groups (n = 10): CN (negative control); DBP100 (BPD; 100 mg/kg) and DBP500 (BPD; 500 mg/kg). Treated animals were exposed from 15th gestation day (GD15) to 21st postnatal day (PND21) by gavage, while the CN animals received corn oil (vehicle). F1 male rats were sacrificed by decapitation in PND1 and PND21 to proceed the blood collect to analysis the testosterone serum levels. The prostatic urethra (DPN1) and the ventral prostate (DPN21) were subjected to histological and immunohistochemical detection for AR (androgen receptor), p63 antigen and α-actin; whereas protein levels: AR, BMP-4 and PCNA were assessed by Western Blot assay. In DPN1, anogenital distance and testosterone levels decreased in animals treated with DBP, and on three-dimensional reconstruction of the prostate, the number of prostatic buds was lower in DBP500 than CN. Immunostaining for AR and α-actin were reduced in the mesenchyme in differentiation, and protein expression of AR and BMP-4 were lower, especially in...
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Santos, Talita de Mello. "Morfogênese da próstata de ratos expostos ao Di-n-Butil-Ftalato (DBP) no período gestacional e lactacional : expressão de proteínas regulatórias sobre a diferenciação glandular." Botucatu, 2015. http://hdl.handle.net/11449/144032.
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Orientador: Raquel Fantin DomeniconiBanca: Wellerson Rodrigo Scarano
Banca: Sebastião Toboga
Banca: Luis Antônio Justilin Jr.
Resumo: Os ftalatos são ésteres utilizados na fabricação de plásticos transparentes empregados na indústria e são amplamente encontrados como substâncias contaminantes no meio ambiente, sendo o tipo mais encontrado, o Di-n-Butil-Ftalato (DBP). Diversos estudos têm mostrado efeitos antiandrogênicos do DBP em ratos expostos durante a vida fetal, refletindo em alterações morfofuncionais sobre órgãos reprodutivos. A morfogênese da próstata é um processo dependente de andrógeno resultante das interações entre mesênquima e epitélio, modulada por fatores de crescimento e algumas moléculas de sinalização. Dentre elas, estão as BMPs que controlam o desenvolvimento de vários tecidos e sofrem influência hormonal. O objetivo deste estudo foi avaliar os efeitos da exposição gestacional e lactacional ao DBP em duas doses (100 e 500mg/kg), sobre a morfogênese inicial e intermediária da próstata de ratos. Assim, fêmeas prenhes da linhagem Wistar foram divididas em 3 grupos experimentais (n=10): CN (controle negativo); DBP100 (DBP; 100 mg/kg) e DBP500 (DBP; 500 mg/kg). Os animais tratados foram expostos ao DBP do 15º dia de gestação (DG15) até o 21º dia pósnatal (DPN21) por gavagem, enquanto os animais CN receberam óleo de milho (veículo). Os animais da geração F1 foram eutanasiados por decapitação nos DPN1 e DPN21, e procedeuse a coleta do sangue para a análise sérica de testosterona. A parte pélvica da uretra (DPN1) e a próstata ventral (DPN21) foram submetidas às análises histológica e imuno-histoquímica para a detecção de AR (receptor de andrógeno), antígeno P63 e α-actina; enquanto que os níveis das proteínas: AR, BMP-4 e PCNA foram avaliados por Western Blot. No DPN1, houve redução na distância anogenital e nos níveis de testosterona nos animais tratados com DPB, e a reconstrução 3D mostrou redução nos números e comprimentos dos brotos no grupo DBP500. A imunomarcação para AR e α-actina foi...
Abstract: Phthalate esters such as Di-n-butyl phthalate (DBP) are used in the manufacture of transparent plastics and they are widely found as contaminants in the environment. Previous studies have shown anti-androgens effects of DBP in rats exposed during fetal life, which presented morphological changes on the reproductive organs. Morphogenesis of the prostate is an androgen-dependent process that depends on interactions between mesenchymal and epithelial cells and it is modulated by growth factors and signaling molecules. Among these molecules, BMPs are important morphogenetic proteins, which are influenced by hormonal levels. These proteins have been implicated in the regulation of prostatic branching morphogenesis. The aim of this study was to evaluate the effects of gestational and lactational exposure to DBP in two doses (100 and 500 mg/kg b.w.) on the initial and intermediate morphogenesis in prostate of rats. Thus, pregnant female rats were divided into 3 groups (n = 10): CN (negative control); DBP100 (BPD; 100 mg/kg) and DBP500 (BPD; 500 mg/kg). Treated animals were exposed from 15th gestation day (GD15) to 21st postnatal day (PND21) by gavage, while the CN animals received corn oil (vehicle). F1 male rats were sacrificed by decapitation in PND1 and PND21 to proceed the blood collect to analysis the testosterone serum levels. The prostatic urethra (DPN1) and the ventral prostate (DPN21) were subjected to histological and immunohistochemical detection for AR (androgen receptor), p63 antigen and α-actin; whereas protein levels: AR, BMP-4 and PCNA were assessed by Western Blot assay. In DPN1, anogenital distance and testosterone levels decreased in animals treated with DBP, and on three-dimensional reconstruction of the prostate, the number of prostatic buds was lower in DBP500 than CN. Immunostaining for AR and α-actin were reduced in the mesenchyme in differentiation, and protein expression of AR and BMP-4 were lower, especially in...
Mestre
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Bob, Mustafa M. "Enhanced removal of natural organic matter during lime-soda softening." Connect to this title online, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1047486107.
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Thesis (Ph. D)--Ohio State University, 2002.Title from first page of PDF file. Document formatted into pages; contains xxii, 119 p.: ill. Includes abstract and vita. Advisor: Harold W. Walker, Civil Engineering Program. Includes bibliographical references (p. 115-119).
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Cooper, James P. "Development of a Chlorine Decay and Trihalomethane Formation Modeling Protocol Using Initial Distribution System Evaluation Data." University of Akron / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=akron1258074886.
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Manigault, Andrew W. "A Test of the Independent and Interactive Effects of Domain-Specific Awareness and Acceptance Manipulations on Cardiovascular Responses to Acute Stress." Ohio University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1575640418648436.
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Liu, Xingjian. "Membrane Electrochemical Treatment of Landfill Leachate: Processes, Performance and Challenges." Diss., Virginia Tech, 2020. http://hdl.handle.net/10919/105173.
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Landfilling is the most common approach to dispose of municipal solid wastes but inevitably leads to leachate formation. Persistent UV quenching substances (UVQS) in landfill leachate can affect the effectiveness of UV disinfection in municipal wastewater treatment systems when leachate co-treatment is applied. Membrane electrochemical reactor (MER) treatment was investigated to reduce the UV quenching capability and simultaneously recover resources in the leachate as an effective onsite pre-treatment. Ion-selective membranes were used in this MER to create two different conditions: a low-pH anolyte for organic oxidation and a high-pH catholyte for ammonia recovery. The MER achieved significantly higher removals of both dissolved organic carbon and UV254nm absorbance than membrane-less electrochemical treatment. The MER was able to remove a large percentage of total nitrogen from the leachate while recovering about half of the influent ammonia in the catholyte with less specific energy consumption. The second study coupled MER with Fenton oxidation through providing synergistic benefits with the low solution pH, reduced organics, and ammonia removal. This two-stage coupled system reduced the more leachate COD than the standalone Fenton process treating raw leachate. Also, the usage of chemicals as Fenton reagents has been greatly reduced: FeSO4 and H2O2 by 39%, H2SO4 by 100%, and NaOH by 55%. Consequently, the sludge production was reduced by 51% in weight and 12% in volume. Despite electricity consumption by the MER, the coupled system cost $4.76 per m3 leachate less than the standalone Fenton treatment. More notably, direct Fenton oxidation removed only 21% of ammonia; in comparison, the MER-Fenton system removed ammonia by 98% with the possibility for recovery at a rate of 30.6 -55.2 kg N m-3 reactor d-1. Those results demonstrated that coupling MER with the Fenton process could mitigate some inherent drawbacks of Fenton oxidation such as ineffective ammonia removal, high acid and chemical reagents dose requirements, and a large amount of sludge generation. The third study investigated the formation of total halogenated organics (DBP) and the associated toxicity as the side effect of leachate treatment in the MER. Compared to the 4538±100 µg L-1 from the control membrane-less electrochemical oxidation reactor, the amount of DBP generated in the MER only accounted for 19.1±4.5 % after the same treatment period. The total toxicity value (26.6 ×10-3 ) was low for MER effluent, only 15.1% of that in the control group. Both high pH and high ammonia concentration introduced more DBP mass and toxicity production after MER treatment. DBP concentrations were shown to increase with applied current density and possible temperature raise. With 67.5% of DBP mass concentration and 74.4% of the additive toxicity removal, the granular activated carbon (GAC) electrode system was shown more effective than GAC adsorption alone in remediating DBP harmful effects. This dissertation introduced MER as a promising technology for the treatment of leachate through performance demonstration, process integration and by-product remediation.Doctor of Philosophy
Municipal solid waste is often disposed of in landfills because of the most economics and convenience. However, one of the most challenging problems is the leachate formation and treatment. In the US, leachate is currently often diluted in domestic wastewater treatment systems; meanwhile, the persistent contaminants in landfill leachate can lower the effectiveness of UV disinfection and result in high cost and permit violation. In this study, the membrane electrochemical reactor (MER) using electricity as the driving force was applied to solve the issue and simultaneously recover valuable resources in the leachate. Membranes as a barrier for selective ions were used in this MER to create two different conditions with different purposes: a low-pH anolyte for organic oxidation and a high-pH catholyte for ammonia recovery. The MER achieved significantly higher contaminants removals than membrane-less electrochemical treatment. The second study coupled MER with one of the established advanced oxidation processes, also known as Fenton oxidation through providing mutual benefits with the low solution pH, reduced organics, and ammonia removal/recovery. This two-stage coupled system reduced the leachate contaminants effectively towards the direct discharge standard. In addition, the usage of chemical reagents, as well as the amount of process residual, has significantly been reduced. The third study investigated the formation of by-products as the side effect of leachate treatment in the MER. Compared to the membrane-less reactor, the undesirable by-products generated in the MER only accounted for one fifth after the same treatment period. A granular activated carbon electrode system was shown effective in remediating the harmful effects. This dissertation introduced MER as a promising technology for the treatment of leachate as one of the toughest wastewaters.
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Júnior, Adalfredo Rocha Lobo. "Melanina na pele e metabólitos da vitamina D3 no plasma associados com polimorfismos nos genes MC1R (loco Extension) e DBP influenciam maciez e cor de carne de bovinos Nelore sem efeito sobre cálcio plasmático e muscular." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/74/74131/tde-23052013-150040/.
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Amaciamento natural devido proteólise miofibrilar pelas enzimas calpaínas (cálcio-dependentes) e descoloração devido oxidação do pigmento mioglobina podem ocorrer em carne maturada. Em bovinos, o tipo biológico Bos indicus apresenta maior atividade de calpastatina (CAST, inibidora das calpaínas) no músculo e concentração de melanina (modulador de vitamina D3) na pele do que Bos taurus. Maior concentração de melanina na pele reduz fotossíntese de vitamina D3 e, subsequentemente, poderia reduzir as concentrações de seus metabólitos 25-hidróxivitamina D3 (25-D) e 1,25-di-hidróxi-vitamina D3 (1,25-D; modulador de cálcio) no plasma de Bos indicus. Nos casos de maiores concentrações de 1,25-D plasmático, uma melhor absorção de cálcio da dieta com aumento de suas concentrações no plasma e músculo poderia resultar em atividade melhorada das calpaínas. Além disso, maiores concentrações de 1,25-D plasmático poderiam colaborar para minimizar oxidação de carne devido sua propriedade antioxidante. Então, além da maior atividade de CAST no músculo, os Bos indicus poderiam ter mais duas desvantagens para produzir carne mais macia e menos oxidada: concentrações maiores de melanina na pele e menores de 1,25-D no plasma. Desta forma, o objetivo deste trabalho foi estudar as relações entre as concentrações de melanina total (MELT) e suas frações [faeumelanina (FAE) e eumelanina (EUM)] na pele, metabólitos da vitamina D3 (25-D e 1,25-D) no plasma, cálcio plasmático e muscular e maciez [Índice de Fragmentação Miofibrilar (MFI) e força de cisalhamento (FC)] e cor (valores de L*, a* e b*) em carne maturada (1, 7 e 14 dias) e suas associações com polimorfismos de um único nucleotídeo (SNPs) nos genes candidatos receptor da melanocortina-1 [MC1R; rs109688013 (C/T) e rs110710422 (G/-)], proteína ligante à vitamina D3 [DBP; rs136359868 (T/C) e rs135330728 (T/C)] e CAST [rs109384915 (T/C)]. Bovinos Nelore (n=86), abatidos com 516 ± 39 kg aos 24 ± 1 meses, foram usados para determinação dos genótipos e mensuração das características. Na pele, a fração EUM foi positivamente correlacionada com MELT, mais do que a fração FAE. As frações de melanina na pele foram correlacionadas negativamente. A fração FAE foi correlacionada negativamente com 1,25-D plasmático, mas não foi correlacionada com 25-D plasmático. Melanina e suas frações na pele e metabólitos da vitamina D3 no plasma não foram correlacionadas com cálcio plasmático e muscular. Todavia, cálcio no plasma e músculo foram correlacionados positivamente com MFI e valores de L* e b* e negativamente com FC e valores de a*. A EUM e MELT na pele foram correlacionadas negativamente com FC e valores de a* e b* e positivamente com valores de L*, enquanto que 25-D no plasma foi correlacionada positivamente com MFI e valores de a* e b* e negativamente com valores de L*. A FAE foi correlacionada positivamente com MFI e negativamente com os valores de L*, a* e b*. No gene MC1R, o alelo T do SNP rs109688013 apresentou-se fixado (100%) na população, enquanto que o alelo G e sua deleção (-) do SNP rs110710422 tiveram frequência de 97,7 e 2,3%, respectivamente. SNPs do gene MC1R resultaram nos genótipos do loco Extension (E/E = T/T + G/G e E/e = T/T + G/-), que foi associado com 1,25-D plasmático e valores de b* no dia 1. No gene DBP, o alelo C do SNP rs136359868 foi menos frequente (3,5%) do que o alelo T, enquanto que os alelos C e T do SNP rs135330728 tiveram uma frequência de 73,8 e 26,2%, respectivamente. SNPs do gene DBP foram associados com MELT na pele e valores de L* e a* em diferentes dias. No gene CAST, os alelos C e T do SNP rs109384915 tiveram a mesma frequência. O SNP rs109384915 foi associado com MFI ao dia 7 e a substituição do alelo T por C reduziu os valores de MFI e a* no dia 7 e os valores de b* no dia 1. Ao final, maiores concentrações de FAE na pele e 25-D no plasma melhoraram proteólise miofibrilar e cor de carne, enquanto as maiores concentrações de EUM e MELT na pele resultaram em uma carne mais macia com uma pior cor. Associações do loco Extension e dos SNPs no gene DBP com cor de carne parecem consequência das diferenças em 1,25-D no plasma e melanina na pele. SNP do CAST associou-se com proteólise miofibrilar e cor de carne maturada, mas não com FC.Natural tenderization by myofibrillar proteolysis through the calpains enzymes (calcium-dependent) and discoloration by oxidation of myoglobin pigment may occur in aged meat. In cattle, the Bos indicus biological type has higher calpastatin activity (CAST, inhibitor of calpains) in muscle and melanin concentration (modulator of vitam in D3) in skin than Bos taurus. Higher melanin concentration in skin reduces photosynthesis of vitamin D3 and, subsequently, could reduce the concentrations of its metabolites 25-hydroxy-vitamin D3 (25-D) and 1,25-di-hydroxy-vitamin D3 (1,25-D; modulator of calcium) in plasma from Bos indicus cattle. In cases of higher plasma 1,25-D concentrations, an improved absorption of calcium from the diet followed by increased plasma calcium concentrations could result in enhanced activity of calpains. Furthermore, higher plasma 1,25-D concentrations could collaborate to minimize meat oxidation due to its antioxidant propriety. Then, in addition to higher CAST activity in muscle, the Bos indicus cattle could have two more disadvantages to produce tender and less oxidized meat: higher melanin concentrations in skin and lower 1,25-D concentrations in plasma. Hence, the objective of this work was to study the relationships between the concentrations of total melanin (MELT) and its fractions [pheomelanin (PHEO) and eumelanin (EUM)] in skin, vitamin D3 metabolites (25-D and 1,25-D) in plasma, plasma and muscle calcium, and tenderness [Myofibrillar Fragmentation Index (MFI) and shear force (SF)] and color (L*, a*, and b* values) in aged meat (1, 7, and 14 days) and their associations with single nucleotide polymorphisms (SNPs) in candidate genes as melanocortin-1 receptor [MC1R; rs109688013 (C/T) and rs110710422 (G/-)], vitamin D3-binding protein [DBP; rs136359868 (T/C) and rs135330728 (T/C)], and CAST [rs109384915 (T/C)]. Nellore cattle (n=86), slaughtered with 516 ± 39 kg at 24 ± 1 months, were used for genotyping and traits measurements. In skin, the EUM fraction was positively correlated with MELT than the PHEO fraction. The melanin fractions in skin were negatively correla ted. The PHEO fraction was negatively correlated with plasma 1,25-D, but not with plasma 25-D. Melanin and its fractions in skin and vitamin D3 metabolites in plasma were not correlated with plasma and muscle calcium. Nevertheless, plasma and muscle calcium were positively correlated with MFI, and L* and b* values and negatively correlated with SF and a* values. The EUM and MELT in skin were negatively correlated with SF, and a* and b* values and positively correlated with L* values, while 25-D in plasma was positively correlated with MFI, and a* and b* values and negatively correlated with L* values. The PHEO was positively correlated with MFI and negatively correlated with L*, a*, and b* values. In MC1R gene, the rs109688013 SNP allele T was fixed (100%) in the population, while the rs110710422 SNP allele G and its deletion (-) had a frequency of 97.7 and 2.3%, respectively. MC1R SNPs resulted in genotypes of the Extension locus (E/E = T/T + G/G and E/e = T/T + G/-), which was associated with plasma 1,25-D and b* values at the day 1. In DBP gene, the rs136359868 SNP allele C was less frequent (3.5%) than allele T, while rs135330728 SNP alleles C and T had a frequency of 73.8 and 26.2%, respectively. DBP SNPs were associated with MELT in skin, and L* and a* values at different days. In CAST gene, the rs109384915 SNP alleles C and T had a similar frequency. The rs109384915 SNP was associated with MFI at the day 7 and the substitution from allele T to C reduced the MFI and a* values at the day 7 and the b* values at the day 1. At last, higher skin PHEO and plasma 25-D concentrations improved the myofibrillar proteolysis and meat color, while higher skin EUM and MELT concentrations resulted in a meat with improved tenderness and worsened color. Associations of the Extension locus and polymorphisms in DBP gene with the meat color seem to be a consequence of the differences in plasma 1,25-D and skin melanin. CAST SNP is associated with myofibrillar proteolysis and meat color, but not with SF.
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Churampi, Munguia Rodolfo Masias. "Descarte de síndrome de Down mediante la relación diámetro biparietal / hueso nasal (dbp/hn) en el segundo trimestre de gestación, en el Centro Materno Infantil “Juan Pablo II” (MINSA) en los meses de noviembre – diciembre 2015." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2016. https://hdl.handle.net/20.500.12672/4945.
Full textAbstract:
Demuestra que la medición del hueso nasal y del diámetro biparietal con la relación DBP/HN en el segundo trimestre de la gestación es confiable para el descarte de fetos con alto riesgo de síndrome de Down por evaluación ultrasonográfica en el Centro Materno Infantil Juan Pablo II, en los meses de noviembre y diciembre de 2015. Es un estudio tipo retrospectivo, longitudinal, cohorte, de tipo descriptivo. Se selecciona 100 informes ecográficos obstétricos entre 14 a 27 semanas de gestación con sus respectivas historias clínicas del neonato, se recolecta la información con un formato de recolección de datos; tomando en cuenta las variables de la medida del hueso nasal, diámetro biparietal y síndrome de Down. Obtiene los siguientes resultados: La edad promedio de madres gestantes es 32.2 años, la longitud promedio del hueso nasal es de 6.3mm, con un valor mínimo de 4.39mm y máximo de 11.1mm.; el coeficiente promedio DBP/HN es de 6.47, con un valor mínimo de 4.22 y máximo de 7.68mm por lo que ninguno de los neonatos tiene síndrome de Down. Concluye que la sensibilidad y el valor predictivo positivo no pudieron ser determinados ya que no se encontraron verdaderos positivos; la especificidad y el valor predictivo negativo fueron de un 100%.Tesis
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Petrov, Brawnie Rebecca. "A New Role for Vitamin D Binding Protein in Bipolar Disorder." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1492642404941773.
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Gramlich, Ludwig. "Die Zukunft der Postdienste in der EG : Zum neuen Grünbuch der EG-Kommission." Universitätsbibliothek Chemnitz, 2009. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-200900491.
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Das von der EG-Kommission 1992 vorgelegte "Grünbuch" zur Liberalisierung der Postdienste wird in Beziehung zum vorausgegangenen Programm für den parallelen Telekommunikationssektor gesetzt und im Hinblick auf die schrittweise Realisierung von Grundfreiheiten gewürdigt. Daneben erfolgt eine Skizze des Neuregelungs- und Änderungsbedarfs im deutschen Postrecht.
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Rignanese, Luigi Pio. "Sviluppo di un sistema di rivelazione per l'esperimento FAMU (fisica degli atomi muonici) basato su scintillatore LaBr3 con fotomoltiplicatore UQE e sistema spettrometrico DSP." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amslaurea.unibo.it/8336/.
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In questa tesi si sono studiati e sviluppati i rivelatori di fotoni x per l’esperimento FAMU (Fisica degli Atomi Muonici gruppo 3 dell’INFN) che indaga sulla natura e la struttura del protone. I rivelatori sono stati assemblati e testati con elementi che rappresentano lo stato dell’arte nel campo dei rivelatori di radiazione (scintillatori LaBr3(Ce) e fotomoltiplicatori Hamamatsu™ Ultra Bi-Alcali). È stata anche studiata e sviluppata parte della catena di formatura del segnale. Questa è stata implementata su un chip FPGA dell’ALTERA™ con buoni risultati per quanto riguarda la qualità del filtro; le performance dell’FPGA non hanno consentito di raggiungere la velocità di 500MHz richiesta dall’esperimento costringendo l’implementazione ad una velocità massima di 320MHz.
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Warfel, Regina M. "Effects of Priming Family versus Friend Support and Non-support on Subsequent Cardiovascular Reactivity to Acute Psychological Stress." Ohio University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1248985718.
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Wujcik, Evan K. "Discovery of Nanostructured Material Properties for Advanced Sensing Platforms." University of Akron / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=akron1374414126.
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Stinson, Jill D. "Got DBT? Understanding and Applying DBT in Sex Offender Treatment." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/7985.
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Stinson, Jill D. "Got DBT? Understanding and Applying DBT in Sex Offender Treatment." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/7981.
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Flemming, Arend. "DBV – LV Sachsen." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-118993.
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Die auf Bundesebene unter breiter Zustimmung der Bibliotheken des Landesverbandes Sachsen beschlossenen Beitragserhöhungen zur weiteren Professionalisierung der Verbandsarbeit insbesondere auf den Gebieten der Lobby- und Öffentlichkeitsarbeit ließen den Fokus des Vorstands natürlich zuerst auf die Mitgliederentwicklung legen.
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Santivañez, Arenas Luis Mauricio. "Evaluación experimental del consumo de combustible y las emisiones gaseosas de un motor diesel utilizando 3 mezclas de diesel y biodiesel: DB5, DB7, 5 y DB10." Bachelor's thesis, Pontificia Universidad Católica del Perú, 2016. http://tesis.pucp.edu.pe/repositorio/handle/123456789/7035.
Full textAbstract:
En la actualidad, el biodiesel constituye una alternativa y un complemento al
diesel para reducir la contaminación ambiental y la escasez de combustibles
fósiles, siendo un medio de energía renovable menos contaminante que el
diesel convencional. Las características de este combustible lo hacen
apropiado para funcionar en motores de encendido por compresión, sin tener
que realizar cambios importantes al diseño del motor.
En el presente trabajo se realizó una evaluación experimental del efecto de la
utilización de 3 mezclas de diesel y biodiesel en porcentajes volumétricos de
5%, 7,5% y 10% (DB5, DB7,5 y DB10) sobre los parámetros relacionados al
consumo de combustible y las emisiones contaminantes. Las pruebas
experimentales se realizaron en un motor Cummins de encendido por
compresión, 6 cilindros, 6.7 litros, turbo cargado; instalado en un banco de
pruebas dinamométrico en el Laboratorio de Energía de la Pontificia
Universidad Católica del Perú.
Las pruebas experimentales consideraron 4 regímenes de giro (1000, 1300,
1600 y 2000 rpm) y 4 niveles de carga: 9.4, 18.8, 28.2 y 37.5 kPa, en términos
de presión media efectiva. Ambas variables fueron establecidas como datos de
entrada para cada ensayo y a partir de estas se midieron y calcularon los
parámetros requeridos.
En términos de desempeño del motor, se calculó la potencia efectiva, el
consumo específico de combustible y el rendimiento efectivo para las 3
mezclas de diesel y biodiesel utilizadas. Los resultados indicaron que la
potencia efectiva aumentó conforme se incrementó la velocidad de giro y carga
del motor, pero se mantuvo constante para las tres mezclas. El consumo
específico de combustible aumentó conforme se incrementó el porcentaje de
biodiesel en la mezcla. El rendimiento efectivo presentó un aumento conforme
se incrementó la carga en los ensayos, pero disminuyó al utilizarse más
biodiesel en la mezcla.
Respecto a los contaminantes gaseosos, se midieron el monóxido de carbono
(CO), dióxido de carbono (CO2) y óxidos de nitrógeno (NOx). A partir de los
valores registrados, se obtuvieron las variaciones porcentuales más
significativas entre las emisiones encontradas para las 3 mezclas empleadas.
Las emisiones de CO y CO2 disminuyeron a medida que se aumentó el
contenido de biodiesel en las mezclas, presentando el CO las variaciones más
significativas. Por otro lado, las emisiones de NOx aumentaron conforme se
incrementó el porcentaje de biodiesel en la mezcla. Los aumentos porcentuales
más altos se encontraron a mayores cargas y velocidades más altas.Tesis
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NAMIKOSHI, Michio, 通夫 浪越, 輝昭 西川, Teruaki NISHIKAWA, 和代 鵜飼, and Kazuyo UKAI. "3種類の海藻ワカメ,マコンブおよびアオサから分離したジブチルフタレート(DBP)およびジ(2-エチルヘキシル)フタレート(DEHP)の^<14>C測定結果の解析(タンデトロン加速器質量分析計業績報告2006(平成18)年度)." 名古屋大学年代測定資料研究センター, 2007. http://hdl.handle.net/2237/13720.
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Aigner, Hans-Jörgen. "Hinzurechnungsbesteuerung und DBA-Recht /." Wien : Linde, 2004. http://www.gbv.de/dms/spk/sbb/recht/toc/385301790.pdf.
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Aigner, Hans J. "Hinzurechnungsbesteuerung und DBA-Recht /." Wien : Linde Verlag, 2004. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=014700983&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
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Weason, Núñez Felipe. "OneChapterOne color - DBZ : http:." Tesis, Universidad de Chile, 2014. http://www.repositorio.uchile.cl/handle/2250/116827.
Full textAbstract:
Magíster en artes medialesEl presente texto tiene como objetivo entregar al lector las claves y nodos que se ubican en los vértices exteriores e interiores (rizoma) del trabajo “onechapteronecolor - dbz” (http://onechapteronecolor-dbz.blogspot.com/) de los cuales se puede bajo las condiciones actuales dibujar parte de sus límites o parte del mundo de conocimiento que lo rodea. Del mismo modo intenta traducir las operaciones, reflexiones y elecciones de índole visual y por definición no verbales a un texto, sin ánimos de que en la traducción se traicione el espacio de silencio propio de su condición, ni tampoco la forma y fondo del modo de reflexión del artista, que no pretende ser ni un periodista, ni antropólogo ni historiador ni menos un teórico del arte de su propio hacer, ya que el conocimiento que se juega aquí no tiene la misma naturaleza ni mucho menos el mismo método de las disciplinas nombradas. Aunque todo pareciera indicar que la traducción tiende hacia la traición. De modo alguno este texto constituye un manual de lectura, base o plataforma de la obra, ni en intención ni en forma. Es con suerte un punto de convergencia anexa, que sustenta su estructura en la performance del artista como relator de su propia obra, como investigador de su propio crimen, con las consecuentes cegueras, autoengaños, egocentrismo y todas aquellas cosas que convierten a un Artista o a su personaje en un pésimo científico.
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Ghorbanian, Sara, and Glenn Fryklund. "Improving DLP system security." Thesis, Blekinge Tekniska Högskola, Institutionen för datalogi och datorsystemteknik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-5453.
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Context. Data leakage prevention (DLP), a system designed to prevent leakage and loss of secret sensitive data and at the same time not affect employees workflow. The aim is to have a system covering every possible leakage point that exist. Even if these are covered, there are ways of hiding information such as obfuscating a zip archive within an image file, detecting this hidden information and preventing it from leaking is a difficult task. Companies pay a great deal for these solutions and yet, as we uncover, the information is not safe. Objectives. In this thesis we evaluate four different existing types of DLP systems out on the market today, disclosing their weaknesses and found ways of improving their security. Methods. The four DLP systems tested in this study cover agentless, agent based, hybrids and regular expression DLP tools. The test cases simulate potential leakage points via every day used file transfer applications and media such as USB, Skype, email, etc. Results. We present a hypothetical solution in order to amend these weaknesses and to improve the efficiency of DLP systems today. In addition to these evaluations and experiments, a complementing proof of concept solution has been developed that can be integrated with other DLP solutions. Conclusions. We conclude that the exisiting DLP systems are still in need of improvement, none of the tested DLP solutions fully covered the possible leakage points that could exist in the corporate world. There is a need for continued evaluation of DLP systems, aspects and leakage points not covered in this thesis as well as a follow up on our suggested solution.
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Dürr, Arndt Christian. "Growth and structure of DIP thin films and Au contacts on DIP thin films." [S.l. : s.n.], 2002. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB10277647.
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Nyström, Daniel. "Multispectral Color Reproduction Using DLP." Thesis, Linköping University, Department of Science and Technology, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1291.
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The color gamut, i.e. the range of reproducible colors, is in most conventional display systems not sufficient for accurate color reproduction of highly saturated colors. Any conventional three-primary display suffers from a color gamut limited within the triangle spanned by the primary colors. Even by using purer primaries, enlarging the triangle, there will still be a problem to cover all the perceivable colors. By using a system with more than three primary colors, in printing denoted Hi-Fi color, the gamut will be expanded into a polygon, yielding a larger gamut and better color reproduction.
Digital Light Processing (DLP) is a projection technology developed by Texas Instrument. It uses a chip with an array of thousands of individually controllable micromirrors, each representing a single pixel in the projected image. A lamp illuminates the micromirrors, and by controlling the amount of time each mirror reflect the light, using pulse width modulation, the projected image is created. Color reproduction is achieved by letting the light pass through color filters, corresponding to the three primaries, mounted in a filter wheel.
In this diploma work, the DLP projector InFocus® LP™350 has been evaluated, using the Photo Research® PR®-705 Spectroradiometer. The colorimetric performance of the projector is found to be surprisingly poor, with a color gamut noticeably smaller then that of a CRT monitor using standardized phosphors. This is due to the broad banded filters used, yielding increased brightness at the expense of the pureness of the primaries.
With the intention of evaluating the potential for the DLP technology in multi- primary systems, color filters are selected for additional primary colors. The filters are selected from a set of commercially available filters, the Kodak Wratten filters for science and technology. Used as performance criteria for filter selection is the volume of the gamut in the CIE 1976 (L*u*v*) uniform color space.
The selected filters are measured and evaluated in combination with the projector, verifying the theoretical results from the filter selection process. Colorimetric performance of the system is greatly improved, yielding an expansion of the color gamut in CIE 1976 (L*u*v*) color space by 79%, relative the original three-primary system. These results indicate the potential for DLP in multiprimary display systems, with the capacity to greatly expand the color gamut, by using carefully selected filters for additional primary colors.
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Stinson, Jill D. "DBT in Practice: Part III." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etsu-works/7991.
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