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Dissertations / Theses on the topic 'Daunorubicin'

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Published: 4 June 2021
Last updated: 25 July 2025

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1

Golightly, L. "Trypanosmoma brucei : Studies on the uptake and effects of daunorubicin and daunorubicin carrier preparations." Thesis, University of Sunderland, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375648.

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2

Hardman, Mark Alan. "Design of potential antiprotozoal daunorubicin derivatives." Thesis, De Montfort University, 1985. http://hdl.handle.net/2086/10737.

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Daunorubicin is an antitumour antibiotic which is highly active against the sleeping sickness parasite Trypanosoma rhodesiense in vitro, but which lacks in vivo activity. The object of this work was to modify daunorubicin so as to promote in vivo activity, and to study the mechanism by which daunorubicin is trypanocidal. A series of daunorubicin analogues, and derivatives in which daunorubicin was linked to a macromolecular carrier (known as daunorubicin conjugates) were prepared, and tested against trypanosome infected mice. Only daunorubicin conjugates in which drug was linked to the carrier
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3

Mohammed, Lina Yousif. "Studies on daunorubicin and actinorhodin type II polyketide synthases." Thesis, University of Bristol, 2018. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.761209.

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4

Wattana-Amorn, Pakorn. "Studies on the actinorhodin and daunorubicin type II polyketide synthases." Thesis, University of Bristol, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441375.

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Bartels, Anna-Maria. "Durchflusszytometrische Untersuchungen zur zellulären Pharmakokinetik von freien und liposomal verkapseltem Daunorubicin." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=965428001.

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6

Maharaj, Vanitha. "A vibrational circular dichroism study of deoxyoctanucleotides and their daunorubicin complexes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/nq20751.pdf.

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7

Bartels, Anna-Maria. "Durchflußzytometrische Untersuchungen zur zellulären Pharmakokinetik von freien und liposomal verkapseltem Daunorubicin." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2002. http://dx.doi.org/10.18452/14780.

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In dieser Arbeit wurde die zelluläre Pharmakokinetik mit den Teilaspekten Invasion, Evasion und intrazellulärer Verteilung sowie die Apoptoseinduktion als Parameter der Pharmakodyna- mik von zwei Anthrazyklinen, dem freien und liposomal verkapseltem Daunorubicin unter- sucht. Die Versuche wurden anhand einer T-lymfatischen Zelllinie, den CEM-Zellen, durchgeführt. Mittels Durchflußzytometer und konfokaler Lasermikroskop wurde die intrazelluläre Fluoreszenz gemessen, die der intrazellulären Konzentration entsprach. Es zeigte sich, dass freies Daunorubicin anfangs deutlich schneller in die Zell
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8

Battisti, Robert F. "Modifying the sugar moieties of daunorubicin overcomes P-gp-mediated multidrug resistance." Connect to resource, 2007. http://hdl.handle.net/1811/25067.

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Thesis (Honors)--Ohio State University, 2007.<br>Title from first page of PDF file. Document formatted into pages: contains 48 p.; also includes graphics. Includes bibliographical references (p. 46-48). Available online via Ohio State University's Knowledge Bank.
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9

Masquelier, Michèle. "Leukemia chemotherapy : experimental studies on pharmacological optimisation /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-046-X/.

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10

Knaust, Eva. "Experimental studies on multidrug resistance in human leukaemia : role of cellular heterogeneity for daunorubicin kinetics /." Linköping : Dept. of Medicine and Care, Univ, 2005. http://www.bibl.liu.se/liupubl/disp/disp2005/med901s.pdf.

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11

Bains, Onkar Singh. "Altered metabolism of daunorubicin and doxorubicin by genetic variants of human aldo-keto and carbonyl reductases." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/29557.

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The anthracyclines, doxorubicin (DOX) and daunorubicin (DAUN) are commonly used to treat a variety of cancers. Their use is associated with life-threatening adverse events, especially chronic cardiotoxicity, in some patients. There may be a genetic basis for this variation, arising from altered metabolism by non-synonymous single nucleotide polymorphisms (ns-SNPs) in genes encoding for the aldo-keto reductase (AKR) and carbonyl reductase (CBR) enzymes, which are responsible for the biotransformation of these two drugs. The first two studies (Chapters 2 and 3) of this thesis examined the effe
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12

Schröder, Anke. "In-vitro-Toxizität der liposomal verkapselten Anthrazykline Daunorubicin (Daunoxome) und Doxorubicin (Caelyx) auf vier verschiedenen Ewing-Sarkom-Zelllinien." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=971791562.

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13

Turnbull, Kenneth James. "The effect of Daunorubicin on human lymphoblastic leukaemia cells and the role of ceramide and ceramide-sensitive protein kinases." Thesis, University of Sheffield, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312330.

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14

Walczak, Robbie J. "Analyses of antibiotic biosyntheses in Streptomyces spp. : the molecular biology of nonactin biosynthesis and the novel biochemistry of daunorubicin biosynthesis /." The Ohio State University, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=osu1488205318510564.

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15

Chen, Wenlan. "Design, Synthesis and Immunological Evaluation of Glycoceramides and Glycoproteins for Cancer Immunotherapy & Structure Activity Relationship Study of Daunorubicin Analogues with Uncommon Sugars." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1280856149.

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16

Löfgren, Christina. "Pharmacological and clinical studies of new ways to improve cytostatic treatment of acute myelocytic leukemia : in vitro and in vivo studies /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-183-0/.

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17

Ghirmai, Senait. "Synthesis of Organic Compounds for Nuclide Therapy : Derivatives of Carboranes, 9-Aminoacridine and Anthracyclines." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4264.

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18

Koeniguer, Sylvie. "Mise au point d'une méthode de dosage par CLHP de la daunorubicine, de l'idarubicine et de leurs métabolites, daunorubicinol et idarubicinol, dans les prélévements pédiatriques." Paris 5, 1998. http://www.theses.fr/1998PA05P122.

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19

Mume, Eskender. "Radiohalogenated Compounds for Tumor Targeting : Synthesis and Radiolabeling." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4817.

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20

Contente, Thaís Costa. "Associação do quimioterápico daunorrubicina a uma nanoemulsão rica em colesterol: estudos de regressão tumoral e farmacocinética." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5166/tde-01022011-183828/.

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A nanoemulsão lipídica (LDE) se concentra nas células neoplásicas e pode ser utilizada como transportador de derivado lipofílico da daunorrubicina, como o Noleil- daunorrubicina (oDNR). Neste estudo, a LDE-oDNR foi preparada por homogeneização em alta pressão e sua toxicidade e atividade anti-tumoral testadas. A associação LDE-oDNR teve rendimento elevado e permaneceu estável por longo período. Em camundongosC57BL/6J, a dose máxima tolerada (DMT) foi 65 vezes maior e a DL50 48 vezes maior no tratamento LDE-oDNR comparado ao tratamento DNR comercial, resultando em alta redução da toxicidade. Em
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21

Flan, Benoît. "La glycosyl-daunorubicine, un modèle d'étude pour le ciblage cellulaire de medicaments." Lille 1, 1990. http://www.theses.fr/1990LIL10059.

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L'existence dans le règne animal de lectines membranaires conduisant à l'endocytose de leur ligand et à son hydrolyse dans les lysosomes, a permis d'envisager le couplage sur le ligand d'un principe actif afin de diriger celui-ci dans l'organisme et de lui permettre d'atteindre sa cible endocellulaire après libération dans le lysosome. Afin d'envisager l'utilisation des glycannes dans le ciblage des médicaments par glycosylation, nous démontrons que ceux-ci interagissent avec le récepteur du galactose des hépatocytes de rat de la même manière que les glycoprotéines et les glycopeptides et que
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22

Haidar, Julie. "Rôle du galactosylcéramide dans l'inhibition de l'apoptose induite par la daunorubicine : implication potentielle des cavéoles." Toulouse 3, 2011. http://www.theses.fr/2011TOU30119.

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La daunorubicine (DNR) est une anthracycline largement utilisée dans le traitement du cancer. Bien que pendant longtemps, on ait considéré que la cytotoxicité de la DNR était essentiellement due aux dommages induits à l'ADN, il est maintenant établi que la DNR peut tuer les cellules selon une modalité de mort programmée, l'apoptose, en activant une voie métabolique. La nature de(s) voie(s) de signalisation impliquée(s) dans l'initiation de l'apoptose induite par la DNR est importante pour la détermination de la chimiosensibilité des cellules tumorales. En effet, la DNR active une voie de signa
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23

Pagé, Brigitte. "Évaluation de la cytotoxicité de conjugués anticorps-peptide-daunorubicine sur des cellules résistantes d'un cancer ovarien." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0005/NQ39386.pdf.

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24

Bailly, Jean-Denis. "Caractérisation des mécanismes de résistance à la daunorubicine et à la mitoxantrone dans des cellules de leucémie aigue myéloi͏̈de de phénotype précoce." Toulouse 3, 1995. http://www.theses.fr/1995TOU30214.

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Les leucemies aigues myeloides representent l'expansion clonale de cellules leucemiques bloquees a un stade donne de la differenciation granulo-monocytaire. Malgre son uniformite apparente, le clone leucemique est organise sur un mode similaire a celui de l'hematopoiese normale avec un compartiment de cellules souches (de phenotype precoce) alimentant le compartiment plus mature des blastes en division terminale, qui constituent la vaste majorite des cellules leucemiques observees dans le sang et la moelle des patients. Les protocoles actuels de chimiotherapie font couramment appel a la daunor
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25

Maestre, Nicolas. "Implication des phospholipides à choline dans la réponse des cellules leucémiques aux agents antitumoraux(daunorubicine, taxotère et aracytine)." Toulouse 3, 2001. http://www.theses.fr/2001TOU30041.

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26

Benzineb, Koulder. "Activation par radiolyse pulsée et gamma d'un médicament antitumoral, la daunorubicine, en présence de peptides et de protéines." Grenoble 2 : ANRT, 1988. http://catalogue.bnf.fr/ark:/12148/cb376118361.

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27

BENZINEB, KOUIDER, and Christiane Bonnelle. "Activation par radiolyse pulsee et par radiolyse gamma d'un medicament antitumoral : la daunorubicine, en presence de peptides et de proteines." Paris 6, 1988. http://www.theses.fr/1988PA066071.

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28

Rojas, Amadó Marta. "Efectes de fàrmacs intercalants del DNA en l'Expressió Gènica a "Saccharomyces cerevisiae"." Doctoral thesis, Universitat de Barcelona, 2007. http://hdl.handle.net/10803/1007.

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S'han estudiat els efectes de dos fàrmacs intercalants al DNA, Daunorubicina (usat com antitumoral) i Criptolepina (amb elevada citotoxicitat i usat com antimalàric), en el llevat "S.cerevisiae".<br/><br/>Ambdues molècules s'uneixen al DNA però amb diferent preferència de seqüència: mentre que la Daunorubicina reconeix preferentment regions 5'(A/T)CG3', la Criptolepina s'uneix a 5'GG3'. S'han descrit nombroses regions reguladores riques en aquest tipu de seqüències, pel que ambdós fàrmacs podrien competir amb factors de transcripció nuclears, modificant l'expressió gènica.<br/><br/>Els princip
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29

Mas, Véronique de. "Role des seconds messagers lipidiques dans la reponse des cellules de leucemies aigues myeloides a la daunorubicine : implication potentielle dans la resistance des progeniteurs leucemiques." Toulouse 3, 1998. http://www.theses.fr/1998TOU30208.

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L'observation clinique suggere que, dans les leucemies aigues myeloides, les progeniteurs leucemiques sont plus resistants au traitement (daunorubicine (dnr)/cytosine arabinoside (ara-c) que les blastes en division terminale. A partir de lignees leucemiques representatives de la differenciation myeloide, nous avons confirme cette observation et montre que la resistance naturelle a la dnr pouvait etre liee a une regulation negative de l'apoptose. Pour comprendre les mecanismes de resistance impliques dans les cellules immatures, nous avons caracterise, dans les cellules matures (sensibles) u937
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30

Udomtanakonchai-Loetchutinat, Chatchanok. "Résistance multiple aux antitumoraux : quantification de l'accumulation de sondes fluorescentes dans différents compartiments intracellulaires par combinaison de la spectrofluorescence conventionnelle et de la cytomètrie en flux." Paris 6, 2001. http://www.theses.fr/2001PA066486.

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31

Dessinges, Aimée. "Synthèse d'hydrates de carbone fluorés et applications biologiques (médecine nucléaire, antibiotiques, inhibiteurs d'enzymes) : les isotopes de l'oxygène en chimie des substances naturelles." Paris 11, 1986. http://www.theses.fr/1986PA112018.

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Cette thèse comporte quatre chapitres distincts. Le premier chapitre traite d'une nouvelle synthèse stéréospécifique du 2-déoxy-2-fluoro-D-glucose et des modifications appropriées 18 à la préparation de son anal gue radioactif, le 2-déoxy-2-[18F] fluoro-D-glucose, utilisé en médecine nucléaire. Dans le deuxième chapitre est rapportée la synthèse de composés fluorés apparentés à l'antibiotique antitumoral, la daunorubicine. Le troisième chapitre traite de la préparation stéréospécifique d'hydrates de carbone dont le carbone-2 est quaternaire et porte les fonctions nitrile et amine ; ceci dans l
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Stierlé, Vérène. "Reversion du phénotype de résistance multiple aux antitumoraux par les petits ARNs interférents." Paris 6, 2005. http://www.theses.fr/2005PA066612.

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33

Boulanger, Mathias. "SUMOylation et contrôle de l’expression des gènes : implication dans la réponse à la chimiothérapie d’induction des Leucémies Aigües Myéloïdes." Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTT067.

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Les Leucémies Aigues Myéloïdes (LAM) sont des hémopathies malignes au pronostic sombre. Leur traitement repose sur une chimiothérapie composée d’une anthracycline (daunorubicine [DNR] ou idarubicine) et d’un analogue de nucléotide (AraC). Cependant, les taux de rechutes sont très élevés. Il est donc critique de mieux comprendre les mécanismes d’actions de ces drogues chimiothérapeutiques pour mieux surmonter la chimiorésistance. Un aspect, essentiel à leur action thérapeutique mais encore mal connu, concerne leur capacité à réguler l’expression de gènes spécifiques qui participent à leur effet
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34

Wilhelm, Matthieu. "Aspects mécanistiques et énergétiques des interactions entre l'ADN et une molécule intercalante." Thesis, Lyon 1, 2012. http://www.theses.fr/2012LYO10108/document.

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L'ADN est au cœur de nombreux processus biologiques. De ce fait, il est la cible de nombreuses molécules pharmacologiques employées notamment dans les thérapies anticancer. Parmi celles-ci, la daunomycine va interagir avec la double hélice d'ADN en s'intercalant entre deux paires de bases, bloquant ainsi la réplication. Malgré l'efficacité reconnue des molécules intercalantes, et de nombreuses études à ce sujet, le mécanisme du processus d'intercalation n'est pas clairement déterminé à l'heure actuelle. Basés sur l'utilisation de la dynamique moléculaire avec une représentation tout atome des
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35

"Daunorubicin kinetics and drug resistance in leukaemia." Thesis, University of Technology, Sydney. Faculty of Science, 1996. http://hdl.handle.net/10453/20146.

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University of Technology, Sydney. Faculty of Science.<br>The aims of this thesis were to examine: (1) plasma and cellular pharmacokinetics of daunorubicin and its major metabolite daunorubicinol in patients with acute leukaemia, and the relationships between pharmacokinetics, patient response and the presence of P glycoprotein; (2) actions of the multidrug resistance reversing agents cyclosporin A and trifluoperazine, at clinically achievable concentrations, on daunorubicin accumulation and retention in human leukaemia cell lines and patients with acute leukaemia; and (3) effect of daunorubici
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"Daunorubicin Kinetics and Drug Resistance in Leukaemia." University of Technology, Sydney. Faculty of Science, 1996. http://hdl.handle.net/2100/247.

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The aims of this thesis were to examine: (1) plasma and cellular pharmacokinetics of daunorubicin and its major metabolite daunorubicinol in patients with acute leukaemia, and the relationships between pharmacokinetics, patient response and the presence of P glycoprotein; (2) actions of the multidrug resistance reversing agents cyclosporin A and trifluoperazine, at clinically achievable concentrations, on daunorubicin accumulation and retention in human leukaemia cell lines and patients with acute leukaemia; and (3) effect of daunorubicin on the cell membrane of both sensitive and resistant ce
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37

Yen-Chun, Peng, and 彭彥鈞. "The Molecular Mechanism of Daunorubicin on the Inhibition of Hepatocellular Growth." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/77295182605923492284.

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碩士<br>中國醫藥學院<br>醫學研究所<br>91<br>Abstract Daunorubicin (DNR), an inhibitor of DNA topoisomerase II, was considered as the treatment of choice for hepatocellular carcinoma. Recent studies found that the therapeutic effect of DNR might be through mitogen-activated protein kinase pathway, apoptosis, and cell cycle arrest; however, the molecular basis of DNR on hepatocellular transformation is still unclear. To evaluate the anti-tumor mechanism of DNR on hepatocytes, we examined the effects of DNR on hepatocellular transformation by anchorage-independent transformation assay. Treatment of
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Chung-Ta, CHANG, and 張仲達. "Study on the Molecular Mechanism of Interaction Between Flavonoids and Daunorubicin." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/25556402962729369290.

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碩士<br>中國醫藥學院<br>醫學研究所<br>91<br>Abstract Primary hepatocellular carcinoma (HCC) is one of the most common tumors in the world. It is especially prevalent in Taiwan, where the annual incidence is up to 28.71 cases per 100,000 population. The most important reason for the high incidence of HCC is the frequency of chronic infection with hepatitis B virus and hepatitis C virus. In addition, alcohol abuse contributes to the development of HCC. There are many therapeutic strategies for the treatment of HCC. For patients who combined with liver cirrhosis or extra-hepatic metastasis, tra
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39

Andreev, Emil. "The human organic cation transporter OCT1 mediates high affinity uptake of the anticancer drug daunorubicin." Thèse, 2016. http://hdl.handle.net/1866/16273.

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Les anthracyclines tels que la doxorubicin et la daunorubicin sont une famille de médicaments anticancéreux hydrophiles qui doivent être transportés dans les cellules afin d’exercer leur action par intercalation à l’ADN dans le noyau cellulaire. Ceci mène à la perturbation du métabolisme de l’ADN et entraine la mort cellulaire. Les anthracyclines sont utilisés pour le traitement d’une variété de cancers incluant la leucémie, les lymphomes, le cancer du sein, le cancer des poumons et le cancer des ovaires. Étant donné que le transport actif des anthracyclines dans les cellules a partiellement é
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40

Bartels, Anna-Maria [Verfasser]. "Durchflußzytometrische Untersuchungen zur zellulären Pharmakokinetik von freien und liposomal verkapseltem Daunorubicin / Anna-Maria Bartels, geb. Hoffmann." 2002. http://d-nb.info/965428001/34.

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41

Sandkötter, Julia [Verfasser]. "In-vitro-Toxizität der Anthrazykline Daunorubicin und Doxorubicin auf vier verschiedenen Ewing-Sarkom-Zelllinien / vorgelegt von Julia Sandkötter." 2008. http://d-nb.info/991567463/34.

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42

伊藤, 裕美. "Transcriptional regulation of neutral sphingomyelinase 2 gene expression of a human breast cancer cell line, MCF-7, induced by the anti-cancer drug, daunorubicin." Thesis, 2011. http://hdl.handle.net/2237/14839.

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43

Lakomá, Petra. "Vliv alisertibu a brigatinibu na aktivitu vybraných lidských karbonylredukujících enzymů." Master's thesis, 2020. http://www.nusl.cz/ntk/nusl-411828.

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Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Petra Lakomá Supervisor: RNDr. Eva Novotná, Ph.D. Title of diploma thesis: The effect of alisertib and brigatinib on the activity of selected human carbonyl reducing enzymes Key words: brigatinib, alisertib, daunorubicin, inhibition, carbonyl-reducing enzymes Protein kinases are enzymes, whose main function is based on a transfer of phosphate group from ATP to protein substrate. This common posttranslational modification is involved in the regulation of intracellular processes and cell signal
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Homerová, Andrea. "Interakce přírodních látek s lidskou aldo-ketoreduktasou 7A2 a dalšími významnými karbonylredukujícími enzymy." Master's thesis, 2019. http://www.nusl.cz/ntk/nusl-396873.

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Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Andrea Homerová Supervisor: RNDr. Eva Novotná, Ph.D. Title of diploma thesis: Interaction of natural substances with human aldo-keto reductase 7A2 and other important carbonyl reducing enzymes Reduction of carbonyl group is one of the phase I metabolism reactions, which is responsible for production of more polar metabolites, enables conjugation in process of biotransformation, excretion of the molecule and it also causes decrease in reactivity and biological activity of the molecule. Endogen
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Tomanová, Alžbeta. "Vliv vybraných inhibitorů tyrosinkinas na aktivitu lidských enzymů redukujících karbonylovou skupinu." Master's thesis, 2019. http://www.nusl.cz/ntk/nusl-404713.

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Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Alžbeta Tomanová Supervisor: RNDr. Eva Novotná, Ph.D. Title of diploma thesis: Effect of selected tyrosine kinase inhibitors on the activity of human carbonyl reducing enzymes Key words: tyrosin kinases, screening, carbonyl, daunorubicin, inhibition Tyrosine kinases are a subclass of protein kinases, catalysing the transfer of ATP phosphate residue to a protein, thereby playing an important role in cellular signaling. Abnormal tyrosine kinase activity is present in various malignancies. I
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"Sphingosine kinase 1 expression is involved in leukemogenesis and modulates cellular sphingolipid rheostat, which is a good predictive marker of daunorubicin sensitivity." Thesis, 2008. http://hdl.handle.net/2237/9693.

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祖父江, 沙矢加, and Sayaka SOBUE. "Sphingosine kinase 1 expression is involved in leukemogenesis and modulates cellular sphingolipid rheostat, which is a good predictive marker of daunorubicin sensitivity." Thesis, 2008. http://hdl.handle.net/2237/9693.

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48

Schröder, Anke [Verfasser]. "In-vitro-Toxizität der liposomal verkapselten Anthrazykline Daunorubicin (Daunoxome) und Doxorubicin (Caelyx) auf vier verschiedenen Ewing-Sarkom-Zelllinien / vorgelegt von Anke Schröder." 2004. http://d-nb.info/971791562/34.

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49

Adamíková, Klára. "HPLC analýza daunorubicinu a jeho metabolitu." Master's thesis, 2013. http://www.nusl.cz/ntk/nusl-322723.

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At present, the High Performance Liquid Chromatography (HPLC) is still the dominant separation method, it is widely used in all areas of drug analysis. HPLC provides qualitative and quantitative evaluation of the separated components. This thesis describes the development of the method for HPLC analysis of daunorubicin (DAU) and its metabolite daunorubicinol (DAU-OL) in a rabbit plasma. The analyzed compounds were first separated from interfering substances in plasma due the deproteinization. For a precipitation was chosen methanol (600 μl) with the highest extraction efficiency. The separatio
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50

Nováková, Mária. "Hodnocení stability daunorubicinu a doxorubicinu pomocí HPLC." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-356255.

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The purpose of this thesis was to determine the stability of doxorubicin and daunorubicin, both in the form of hydrochloride, in water, in a rabbit application solution (0.9% NaCl solution), and culture medium using HPLC with a fluorescence detector. Doxorubicin and daunorubicin belong to the group of anthracycline antibiotics used in the treatment of various types of cancer. The stability of the substances has been investigated in water and 0.9% NaCl stored in glass and plastic (polypropylene) at room temperature in light and dark for 24 hours, in a refrigerator (8řC) for 3 months, in a freez
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