Journal articles on the topic 'DARE programme'
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Bean, Philip. "Drug Prevention and the DARE Programme in Britain." International Review of Law, Computers & Technology 12, no. 3 (October 1998): 487–500. http://dx.doi.org/10.1080/13600869855324.
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Lindström, Peter, and Robert Svensson. "Attitudes towards drugs among school youths: An evaluation of the Swedish DARE programme." Nordic Studies on Alcohol and Drugs 15, no. 1_suppl (February 1998): 7–23. http://dx.doi.org/10.1177/145507259801501s01.
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Illicit drug use among high school students is on the rise in Sweden as well as in other countries. This fact has put high demand on the police, who are not only expected to reduce the availability of drugs but also to take part in the effort to affect the students' demand for drugs. The aim of this study was to analyse what impact students' demand for and perceived availability of illicit drugs in the seventh grade have on their attitudes towards and experience with drugs in the eighth grade. Moreover, the purpose was to investigate to what extent a specific police-led school-based drug prevention programme, the project DARE (Drug Abuse Resistance Education), affects students' attitudes and experiences regarding drugs. As a part in an ongoing evaluation of the Swedish DARE programme (called VÅGA) about 1,800 students in 22 Swedish junior high schools on three occasions anonymously answered questions about their attitudes towards and experiences with drugs. Contextual analysis was used to estimate the significance of various student-level risk-factors (such as family bonding, school involvement, and peer activity) and school aggregated contextual factors. The results show that students' curiosity and perceived availability of illicit drugs at the school-level have statistically significant effects on drug-related attitudes and experiences at the individual-student level. The attitudes towards and experiences with drugs in the eighth grade of students who participated in the DARE programme in the seventh grade were not different from those students who did not participate in the programme. A brief discussion of what measures the police should conduct in order to block the availability of drugs and what their role in schools should be are finally presented.
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Yong, Wei Wei Dayna, Phek Hui Jade Kua, Swee Sung Soon, Pin Pin Maeve Pek, and Marcus Eng Hock Ong. "DARE Train-the-Trainer Pedagogy Development Using 2-Round Delphi Methodology." BioMed Research International 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/5460964.
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The Dispatcher-Assisted first REsponder programme aims to equip the public with skills to perform hands-only cardiopulmonary resuscitation (CPR) and to use an automated external defibrillator (AED). By familiarising them with instructions given by a medical dispatcher during an out-of-hospital cardiac arrest call, they will be prepared and empowered to react in an emergency. We aim to formalise curriculum and standardise the way information is conveyed to the participants. A panel of 20 experts were chosen. Using Delphi methodology, selected issues were classified into open-ended and close-ended questions. Consensus for an item was established at a 70% agreement rate within the panel. Questions that had 60%–69% agreement were edited and sent to the panel for another round of voting. After 2 rounds of voting, 70 consensus statements were agreed upon. These covered the following: focus of CPR; qualities and qualifications of trainers; recognition of agonal breathing; head-tilt-chin lift; landmark for chest compression; performance of CPR when injuries are present; trainers’ involvement in training lay people; modesty of female patients during CPR; AED usage; content of trainer’s manual; addressing of questions and answers; updates-dissemination to trainers and attendance of refresher courses. Recommendations for pedagogy for trainers of dispatcher-assisted CPR programmes were developed.
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Misilei, Jolene, and Chern Li Liew. "Perceived value of digital components in library programmes: The case of Auckland Libraries' Dare to Explore summer reading programme." Library & Information Science Research 40, no. 3-4 (July 2018): 219–36. http://dx.doi.org/10.1016/j.lisr.2018.09.004.
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Bannigan, Katrina. "Clinical Effectiveness: Systematic Reviews and Evidence-Based Practice in Occupational Therapy." British Journal of Occupational Therapy 60, no. 11 (November 1997): 479–83. http://dx.doi.org/10.1177/030802269706001105.
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Evidence-based health care can be defined as an approach to health care that involves finding and using up-to-date research into the effectiveness of health care interventions to inform decision making (Entwistle et al, 1996). For many occupational therapists, the practicalities of keeping up to date with the best research evidence is difficult; however, through the National Health Service Centre for Reviews and Dissemination (NHS CRD), the NHS Research and Development (R&D) Programme is aiming to improve the availability of high quality research evidence to all health care professionals. The NHS CRD carries out and commissions systematic reviews. Systematic reviews are a means of pulling together large quantities of research information and are considered to be one of the most reliable sources of information about effectiveness (Chalmers and Altman, 1995). The NHS CRD also disseminates the findings of systematic reviews, one method of which is through the Database of Abstracts of Reviews of Effectiveness (DARE). The relevance of systematic reviews to the clinical practice of occupational therapists is explored in this paper using two examples: a poor quality and a high quality systematic review identified from the abstracting process for DARE. Both reviews are directly relevant to occupational therapy, being about sensory integration and falls in the elderly respectively. The implications of these reviews for evidence-based practice in occupational therapy are discussed.
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Ab. Latif, Nur Afiqah, and Che Nooryohana Zulkifli. "Peer-Tutoring: An Approach to Enhance Students’ Motivation to Learn English." Sains Insani 5, no. 2 (November 30, 2020): 25–31. http://dx.doi.org/10.33102/sainsinsani.vol5no2.204.
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English language has always been a challenging subject for some students in Malaysia (Normazidah Che Musa, Lie & Hazita Azman, 2012). Despite the fact that these students have learned English for almost ten years in school, they are still facing problems to learn it mostly due to language anxiety (Nur Afiqah Ab. Latif, 2015). This study was conducted to identify the effectiveness of peer-tutoring approach as one way to lower the students’ anxiety level as well as to boost their motivation in learning English language. This study was conducted in a public university in Malaysia where seventeen pre-diploma students were selected to join a ‘Mentor-mentee’ programme as the mentees while five diploma (semester three) students were chosen to be the mentors. The mentors were asked to coach the pre-diploma students in learning English language by using four interesting and interactive English games namely ‘Truth or Dare’, ‘Roll the Dice, ‘Spot the Error’ and ‘Once upon a Time’. The researchers used a google form to get responses from the participants and the results show that the peer-tutoring programme has appeared to create a more relaxed and friendly environment for the students to learn English, thus boost their motivation in learning English.
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Donadel, Marcia. "Online education and the feeling of (dis)embodiment: A somatic perspective of a learning experience." Journal of Dance & Somatic Practices 12, no. 1 (August 1, 2020): 155–61. http://dx.doi.org/10.1386/jdsp_00019_7.
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The thinking in this short report emerged from the author’s participation as an online learner in the TBI 101 course on Mabel Elsworth Todd by Pamela Matt, The Thinking Body Institute.2 Participation in this course, during a Ph.D. internship period at C-DaRE, Coventry University as a visiting researcher in 2018, prompted reflections on e-learning and feelings of embodied or disembodied experience, particularly in close connection to the author’s doctoral research on sensory and creative possibilities of a somatic approach to improvisation in performer training. This report reviews the pedagogical and technological challenges of the TBI 101 study programme in order to better understand the potential connections between (dis)embodied research and online learning, and to offer a foundation for a somatic point of view on e-learning. The thinking offered here investigates different levels of (dis)embodied engagement, suggesting it is dependent on the synergy of the participant’s learning style, the technological platform and the pedagogical approach.
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Burger-Stritt, Stephanie, Annemarie Eff, Marcus Quinkler, Tina Kienitz, Bettina Stamm, Holger S. Willenberg, Gesine Meyer, et al. "Standardised patient education in adrenal insufficiency: a prospective multi-centre evaluation." European Journal of Endocrinology 183, no. 2 (August 2020): 119–27. http://dx.doi.org/10.1530/eje-20-0181.
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Objective Patients with adrenal insufficiency (AI) suffer from impaired quality of life and are at risk of adrenal crisis (AC) despite established replacement therapy. Patient education is regarded an important measure for prevention of AC and improvement of AI management. A standardized education programme was elaborated for patients with chronic AI in Germany. Design Longitudinal, prospective, questionnaire-based, multi-centre study. Methods During 2-h sessions, patients (n = 526) were provided with basic knowledge on AI, equipped with emergency cards and sets and trained in self-injection of hydrocortisone. To evaluate the education programme, patients from eight certified centres completed questionnaires before, immediately after and 6–9 months after training. Results 399 completed data sets were available for analysis. Questionnaire score-values were significantly higher after patient education, indicating successful knowledge transfer (baseline: 17 ± 7.1 of a maximum score of 29; after training: 23 ± 4.2; P < 0.001), and remained stable over 6–9 months. Female sex, younger age and primary cause of AI were associated with higher baseline scores; after education, age, cause of AI and previous adrenal crisis had a significant main effect on scores. 91% of patients would dare performing self-injection after training, compared to 68% at baseline. An improvement of subjective well-being through participation in the education programme was indicated by 95% of the patients 6–9 months after participation. Conclusion Patient group education in chronic AI represents a helpful tool for the guidance of patients, their self-assurance and their knowledge on prevention of adrenal crises. Repeated training and adaptation to specific needs, for example, of older patients is needed.
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Hashem, Ferhana, Charlotte Brigden, Patricia Wilson, and Claire Butler. "Understanding what works, why and in what circumstances in hospice at home services for end-of-life care: Applying a realist logic of analysis to a systematically searched literature review." Palliative Medicine 34, no. 1 (December 18, 2019): 16–31. http://dx.doi.org/10.1177/0269216319867424.
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Background: We have undertaken a systematically searched literature review using a realist logic of analysis to help synthesise the diverse range of literature available on hospice at home services. Aim: To find out in the existing literature what features of hospice at home models work best, for whom and under what circumstances. Design: A realist logic of analysis was applied to synthesise the evidence focusing on mechanisms by which an intervention worked (or did not work). An initial programme theory was developed using the National Association for Hospice at Home standards, Normalisation Process Theory and through refinement using stakeholder engagement. Data sources: PubMed, Science Direct, AMED, BNI, CINAHL, EMBASE, Health Business Elite, HMIC, Medline, PsychINFO, SCOPUS, Web of Science, DARE, Google Scholar, NHS Evidence, NIHR CRN portfolio database, NIHR journal library of funded studies, including searches on websites of relevant professional bodies (August 2014, June 2017, June 2019). Results: Forty-nine papers were reviewed, of which 34 contributed evidence to at least one of the eight theory areas: marketing and referral, sustainable funding model, service responsiveness and availability, criteria for service admission, knowledge and skills of care providers, integration and coordination, anticipatory care, support directed at carers. Conclusions: Our literature review showed how it was possible to develop a coherent framework and test it against 34 published papers and abstracts. Central to this review was theory building, and as further evidence emerges, our programme theories can be refined and tested against any new empirical evidence.
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Rajesh, Mudivedu Shroff, and Nandikotkur Padmaja. "Now I know Dorothy!" Acta Crystallographica Section A Foundations and Advances 70, a1 (August 5, 2014): C1314. http://dx.doi.org/10.1107/s2053273314086859.
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"Our message is – dare I say – crystal clear," observed UNESCO Director-General Irina Bokova in her opening remarks at UNESCO headquarters in Paris on 20 January 2014. At exactly the same time some 6480.2 miles away in a school at Hyderabad, India echoed a message "Now I know Dorothy" this was an excited exclamation from hundreds of high school children. The occasion was an IYCr2014 outreach programme motivated and supported by the President of the International Union of Crystallography (IUCr) Professor Gautam R. Desiraju. The occasion was an IYCr2014 outreach programme that matched IYCr2014 goals and objectives. The project next moved to smaller places. To make IYCr2014 relevant specifically to young students in villages and small towns, it was thought that the student audience must be comprised from non-English medium schools. This prompted translating "Crystallography Matters!" from English to a widely spoken (60 million) South Indian language called Telugu. the next step was to prepare power point presentations in Telugu, prepare crystallography related simple multiple choice questions, quiz papers, buy chocolates to represent crystallization process in making chocolates, sugar candy (Kalkand) to show them real crystals so that students connect to the subject with ease. Then travel to schools and start with an introduction to what and why is IYCr, demonstrate uses of crystals with examples, tell them why we cannot use microscope to "see" the inside of crystals, lecture, demo interactive sessions and so on .The presentation involved introducing science behind crystallography, explaining how to grow crystals, relevance to everyday life with references to NaCl and other medical uses. Sessions end with taking questions, ask mass questions like who is Dorothy, poster readings, who is Bragg, valuations of quiz papers and distribution of prizes, chocolates and sugar candy. Finally Crystallography Matters! books are given to the students and copies to school libraries.
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MacDonald, Calum. "Birmingham: John Foulds at Symphony Hall." Tempo 58, no. 229 (July 2004): 75–77. http://dx.doi.org/10.1017/s0040298204250240.
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The City of Birmingham Symphony Orchestra's conductor, Sakari Oramo, took up the cause of the long-neglected and little-regarded British composer John Foulds (1880–1939) in the late 1990s, as soon as he was appointed to his present post. This February saw his most high-profile push on Foulds's behalf so far, with performances of three Foulds works – one of them a UK and concert première, another a world première – in three Symphony Hall concerts, two of them broadcast on BBC Radio 3. This was followed by a CD recording for Warner Classics of these three pieces plus a fourth, Foulds's early elegy for violin and orchestra, Apotheosis. Intervening in one of the pre-concert talks, Oramo stated his conviction that after decades of misunderstanding during his lifetime, and half a century of neglect thereafter, ‘we owe it to this remarkable composer to play his music – and play it often’. It is difficult to think that any London orchestra would dare to programme anything so distant from their narrow core repertoire and so utterly contrary to contemporary fashions. Yet three near-capacity audiences were plainly both surprised and enthralled by the music, and many members of the public expressed a desire to hear more.
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Young, Pat. "'Scholarship is the word that dare not speak its name' Lecturers' Experiences of Teaching on a Higher Education Programme in a Further Education College." Journal of Further and Higher Education 26, no. 3 (August 2002): 273–86. http://dx.doi.org/10.1080/03098770220149620a.
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Cowie, Julie, Pauline Campbell, Elena Dimova, Avril Nicoll, and Edward A. S. Duncan. "Improving the sustainability of hospital-based interventions: a study protocol for a systematic review." BMJ Open 8, no. 9 (September 2018): e025069. http://dx.doi.org/10.1136/bmjopen-2018-025069.
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IntroductionSustaining effective interventions in hospital environments is essential to improving health outcomes, and reducing research waste. Current evidence suggests many interventions are not sustained beyond their initial delivery. The reason for this failure remains unclear. Increasingly research is employing theoretical frameworks and models to identify critical factors that influence the implementation of interventions. However, little is known about the value of these frameworks on sustainability. The aim of this review is to examine the evidence regarding the use of theoretical frameworks to maximise effective intervention sustainability in hospital-based settings in order to better understand their role in supporting long-term intervention use.Methods and analysisSystematic review. We will systematically search the following databases: Medline, AMED, CINAHL, Embase and Cochrane Library (CENTRAL, CDSR, DARE, HTA). We will also hand search relevant journals and will check the bibliographies of all included studies. Language and date limitations will be applied. We will include empirical studies that have used a theoretical framework (or model) and have explicitly reported the sustainability of an intervention (or programme). One reviewer will remove obviously irrelevant titles. The remaining abstracts and full-text articles will be screened by two independent reviewers to determine their eligibility for inclusion. Disagreements will be resolved by discussion, and may involve a third reviewer if required. Key study characteristics will be extracted (study design, population demographics, setting, evidence of sustained change, use of theoretical frameworks and any barriers or facilitators data reported) by one reviewer and cross-checked by another reviewer. Descriptive data will be tabulated within evidence tables, and key findings will be brought together within a narrative synthesis.Ethics and disseminationFormal ethical approval is not required as no primary data will be collected. Dissemination of results will be through peer-reviewed journal publications, presentation at an international conference and social media.PROSPERO registration numberCRD42017081992.
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Nicoletta, Ricciardulli, and Tenna Fabrizio. "L'applicazione delle metodologie proposte dal manuale del Quadro Comune di Monitoraggio e Valutazione (QCMV) alla Valutazione dei Programmi di Sviluppo Rurale 2007-2013: limiti attuali e spunti di riflessione per il futuro." RIV Rassegna Italiana di Valutazione, no. 48 (January 2012): 103–13. http://dx.doi.org/10.3280/riv2010-048008.
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Il manuale del Quadro Comune di Monitoraggio e Valutazione (d'ora in poi QCMV) definisce la valutazione come "un processo [di ricerca] che permette di giudicare gli interventi in funzione dei risultati e degli impatti [da essi determinati] e dei fabbisogni che intendono soddisfare". Questo paradigma č definito all'interno del regolamento per lo sviluppo rurale per consentire, attraverso la misurazione degli indicatori, di valutare la situazione di partenza nonché l'esecuzione finanziaria, i prodotti, i risultati e l'impatto dei programmi, verificando l'andamento, l'efficienza e l'efficacia dei programmi di sviluppo rurale rispetto ai loro obiettivi. L'articolo entra nel merito del meccanismo che la Commissione ha messo in piedi per il monitoraggio e la valutazione dei Programmi di sviluppo rurale, analizzandone le ripercussioni rispetto a ciň che dovrebbe essere la funzione degli indicatori nella valutazione e il loro senso in funzione della programmazione. Vi č un potenziale cortocircuito nella scelta di indicatori di programma, i cui target sono ancorati a stime poco consistenti, e nel dare mandato alla valutazione di basarsi sulla performance di tali indicatori per verificare l'efficienza e l'efficacia del programma. Gli autori affrontano con esempi concreti i limiti metodologici e suggeriscono un approccio alternativo per la futura programmazione.
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Puchta, Artur. "Podróże kształcą. Wymiana studencka w ramach programu Erasmus LLP – na przykładzie Szkoły Głównej Gospodarstwa Wiejskiego w Warszawie." Zeszyty Naukowe. Turystyka i Rekreacja 16, no. 2 (December 10, 2015): 165–78. http://dx.doi.org/10.5604/01.3001.0008.2391.
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Program Erasmus LLP stanowił jeden z najpopularniejszych systemów wymiany studentów w Europie. Wraz z otwarciem nowej perspektywy Erasmus+ warto sobie zadać pytanie o kształt oraz zasięg kończącego się programu Erasmus Lifelong Learning Programme w ramach europejskiego systemu edukacji. Artykuł koncentruje się na przedstawieniu różnic w partycypacji w programie w różnych krajach Europy, które stanowią swoiste tło dla szerszych porównań dotyczących już bardzo konkretnego obszaru uczelni rolniczych. Głównym celem artykułu jest zweryfikowanie tezy o statystycznym podobieństwie uczestników programu Erasmus LLP pochodzących ze Szkoły Głównej Gospodarstwa Wiejskiego i stypendystów wybranych europejskich szkół rolniczych w oparciu o dane z roku akademickiego 2013/14.
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Kelly, Peter, Xinghua Li, Johan Vanparys, and Carole Zimmer. "A comparison of the perceptions and practices of Chinese and French-speaking Belgian university students in the learning of English." ITL - International Journal of Applied Linguistics 113-114 (January 1, 1996): 275–303. http://dx.doi.org/10.1075/itl.113-114.05kel.
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Abstract This paper describes the first stage of a pedagogically oriented programme of research, the ultimate objective being to facilitate the learning of lexis within the context of the language learning programmes already developed within our respective universities, namely, the Facultés Universitaires Notre-Dame de la Paix (Namur, Belgium) and Wuhan University of Hydraulic and Electrical Engineering (Wuhan, China). This first stage consists in exploring the personal language learning practices and perceptions of the student populations concerned. We have already completed the second stage which attempts to highlight the most salient and persistent difficulties encountered by our respective student populations. At present, we are investigating various exercises and techniques which, in the light of theoretical and empirical findings, should facilitate their learning of lexis; if proved effective, they would eventually be integrated into the existing language programmes.
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Hanratty, Barbara, Dawn Craig, Katie Brittain, Karen Spilsbury, John Vines, and Paul Wilson. "Innovation to enhance health in care homes and evaluation of tools for measuring outcomes of care: rapid evidence synthesis." Health Services and Delivery Research 7, no. 27 (July 2019): 1–178. http://dx.doi.org/10.3310/hsdr07270.
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BackgroundFlexible, integrated models of service delivery are being developed to meet the changing demands of an ageing population. To underpin the spread of innovative models of care across the NHS, summaries of the current research evidence are needed. This report focuses exclusively on care homes and reviews work in four specific areas, identified as key enablers for the NHS England vanguard programme.AimTo conduct a rapid synthesis of evidence relating to enhancing health in care homes across four key areas: technology, communication and engagement, workforce and evaluation.Objectives(1) To map the published literature on the uses, benefits and challenges of technology in care homes; flexible and innovative uses of the nursing and support workforce to benefit resident care; communication and engagement between care homes, communities and health-related organisations; and approaches to the evaluation of new models of care in care homes. (2) To conduct rapid, systematic syntheses of evidence to answer the following questions. Which technologies have a positive impact on resident health and well-being? How should care homes and the NHS communicate to enhance resident, family and staff outcomes and experiences? Which measurement tools have been validated for use in UK care homes? What is the evidence that staffing levels (i.e. ratio of registered nurses and support staff to residents or different levels of support staff) influence resident outcomes?Data sourcesSearches of MEDLINE, CINAHL, Science Citation Index, Cochrane Database of Systematic Reviews, DARE (Database of Abstracts of Reviews of Effects) and Index to Theses. Grey literature was sought via Google™ (Mountain View, CA, USA) and websites relevant to each individual search.DesignMapping review and rapid, systematic evidence syntheses.SettingCare homes with and without nursing in high-income countries.Review methodsPublished literature was mapped to a bespoke framework, and four linked rapid critical reviews of the available evidence were undertaken using systematic methods. Data were not suitable for meta-analysis, and are presented in narrative syntheses.ResultsSeven hundred and sixty-one studies were mapped across the four topic areas, and 65 studies were included in systematic rapid reviews. This work identified a paucity of large, high-quality research studies, particularly from the UK. The key findings include the following. (1) Technology: some of the most promising interventions appear to be games that promote physical activity and enhance mental health and well-being. (2) Communication and engagement: structured communication tools have been shown to enhance communication with health services and resident outcomes in US studies. No robust evidence was identified on care home engagement with communities. (3) Evaluation: 6 of the 65 measurement tools identified had been validated for use in UK care homes, two of which provide general assessments of care. The methodological quality of all six tools was assessed as poor. (4) Workforce: joint working within and beyond the care home and initiatives that focus on staff taking on new but specific care tasks appear to be associated with enhanced outcomes. Evidence for staff taking on traditional nursing tasks without qualification is limited, but promising.LimitationsThis review was restricted to English-language publications after the year 2000. The rapid methodology has facilitated a broad review in a short time period, but the possibility of omissions and errors cannot be excluded.ConclusionsThis review provides limited evidential support for some of the innovations in the NHS vanguard programme, and identifies key issues and gaps for future research and evaluation.Future workFuture work should provide high-quality evidence, in particular experimental studies, economic evaluations and research sensitive to the UK context.Study registrationThis study is registered as PROSPERO CRD42016052933, CRD42016052933, CRD42016052937 and CRD42016052938.FundingThe National Institute for Health Research Health Services and Delivery Research programme.
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Kwiatkowska, Elżbieta. "Drama w przedszkolu – jej zintegrowany potencjał." Annales Universitatis Paedagogicae Cracoviensis | Studia de Cultura 11, no. 2 (July 7, 2019): 123–38. http://dx.doi.org/10.24917/20837275.11.2.10.
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Artykuł stanowi rozważania na temat stosowania metod dramowych w edukacji przedszkol- nej. Specyfika rozwoju dziecka w tym okresie oraz obowiązujący w edukacji dzieci młod- szych w Polsce tzw. zintegrowany model nauczania stwarza szerokie pole zastosowań dramy w pracy z najmłodszymi dziećmi. Przytoczone w artykule dane potwierdzają, iż aktywny udział w zajęciach dramowych (na przykładzie grupy wiekowej 13–16 lat) znacząco podwyż- sza funkcjonowanie w szkole, w domu, rozwija wyobraźnię, daje lepsze efekty uczenia się, rozwija postawy przedsiębiorcze, wpływa na rozwój empatii, zaangażowania, uczestnictwo w kulturze itd. Przedstawiony model pracy z wykorzystaniem dramy w programie wycho- wania w przedszkolu, wskazuje na wybrane spośród dużej puli aspekty wspierające, sty- mulujące rozwój dziecka. Drama w ujęciu projektowym to spektrum aktywności związanych z aktywnością plastyczną, muzyczną, literacką, społeczną, fizyczną, poznawczą itd. Ostatnia część artykułu skupia się na postaci nauczyciela edukacji przedszkolnej. Przedstawiono efek- ty pilotażowego sondażu diagnostycznego, którego wyniki mogą stać się podstawą do dalszych eksploracji badawczych.
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Whiting, Penny, Maiwenn Al, Marie Westwood, Isaac Corro Ramos, Steve Ryder, Nigel Armstrong, Kate Misso, Janine Ross, Johan Severens, and Jos Kleijnen. "Viscoelastic point-of-care testing to assist with the diagnosis, management and monitoring of haemostasis: a systematic review and cost-effectiveness analysis." Health Technology Assessment 19, no. 58 (July 2015): 1–228. http://dx.doi.org/10.3310/hta19580.
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BackgroundPatients with substantive bleeding usually require transfusion and/or (re-)operation. Red blood cell (RBC) transfusion is independently associated with a greater risk of infection, morbidity, increased hospital stay and mortality. ROTEM (ROTEM®Delta, TEM International GmbH, Munich, Germany;www.rotem.de), TEG (TEG®5000 analyser, Haemonetics Corporation, Niles, IL, USA;www.haemonetics.com) and Sonoclot (Sonoclot®coagulation and platelet function analyser, Sienco Inc., Arvada, CO) are point-of-care viscoelastic (VE) devices that use thromboelastometry to test for haemostasis in whole blood. They have a number of proposed advantages over standard laboratory tests (SLTs): they provide a result much quicker, are able to identify what part of the clotting process is disrupted, and provide information on clot formation over time and fibrinolysis.ObjectivesThis assessment aimed to assess the clinical effectiveness and cost-effectiveness of VE devices to assist with the diagnosis, management and monitoring of haemostasis disorders during and after cardiac surgery, trauma-induced coagulopathy and post-partum haemorrhage (PPH).MethodsSixteen databases were searched to December 2013: MEDLINE (OvidSP), MEDLINE In-Process and Other Non-Indexed Citations and Daily Update (OvidSP), EMBASE (OvidSP), BIOSIS Previews (Web of Knowledge), Science Citation Index (SCI) (Web of Science), Conference Proceedings Citation Index (CPCI-S) (Web of Science), Cochrane Database of Systematic Reviews (CDSR), Cochrane Central Register of Controlled Trials (CENTRAL), Database of Abstracts of Reviews of Effects (DARE), Health Technology Assessment (HTA) database, Latin American and Caribbean Health Sciences Literature (LILACS), International Network of Agencies for Health Technology Assessment (INAHTA), National Institute for Health Research (NIHR) HTA programme, Aggressive Research Intelligence Facility (ARIF), Medion, and the International Prospective Register of Systematic Reviews (PROSPERO). Randomised controlled trials (RCTs) were assessed for quality using the Cochrane Risk of Bias tool. Prediction studies were assessed using QUADAS-2. For RCTs, summary relative risks (RRs) were estimated using random-effects models. Continuous data were summarised narratively. For prediction studies, the odds ratio (OR) was selected as the primary effect estimate. The health-economic analysis considered the costs and quality-adjusted life-years of ROTEM, TEG and Sonoclot compared with SLTs in cardiac surgery and trauma patients. A decision tree was used to take into account short-term complications and longer-term side effects from transfusion. The model assumed a 1-year time horizon.ResultsThirty-one studies (39 publications) were included in the clinical effectiveness review. Eleven RCTs (n = 1089) assessed VE devices in patients undergoing cardiac surgery; six assessed thromboelastography (TEG) and five assessed ROTEM. There was a significant reduction in RBC transfusion [RR 0.88, 95% confidence interval (CI) 0.80 to 0.96; six studies], platelet transfusion (RR 0.72, 95% CI 0.58 to 0.89; six studies) and fresh frozen plasma to transfusion (RR 0.47, 95% CI 0.35 to 0.65; five studies) in VE testing groups compared with control. There were no significant differences between groups in terms of other blood products transfused. Continuous data on blood product use supported these findings. Clinical outcomes did not differ significantly between groups. There were no apparent differences between ROTEM or TEG; none of the RCTs evaluated Sonoclot. There were no data on the clinical effectiveness of VE devices in trauma patients or women with PPH. VE testing was cost-saving and more effective than SLTs. For the cardiac surgery model, the cost-saving was £43 for ROTEM, £79 for TEG and £132 for Sonoclot. For the trauma population, the cost-savings owing to VE testing were more substantial, amounting to per-patient savings of £688 for ROTEM compared with SLTs, £721 for TEG, and £818 for Sonoclot. This finding was entirely dependent on material costs, which are slightly higher for ROTEM. VE testing remained cost-saving following various scenario analyses.ConclusionsVE testing is cost-saving and more effective than SLTs, in both patients undergoing cardiac surgery and trauma patients. However, there were no data on the clinical effectiveness of Sonoclot or of VE devices in trauma patients.Study registrationThis study is registered as PROSPERO CRD42013005623.FundingThe NIHR Health Technology Assessment programme.
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Westwood, Marie, Bram Ramaekers, Shona Lang, Nigel Armstrong, Caro Noake, Shelley de Kock, Manuela Joore, Johan Severens, and Jos Kleijnen. "ImmunoCAP® ISAC and Microtest for multiplex allergen testing in people with difficult to manage allergic disease: a systematic review and cost analysis." Health Technology Assessment 20, no. 67 (September 2016): 1–178. http://dx.doi.org/10.3310/hta20670.
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BackgroundAllergy is a form of immune-mediated exaggerated sensitivity (hypersensitivity) to a substance that is either inhaled, swallowed, injected or comes into contact with the skin. Foreign substances that provoke allergies are called allergens. It has been claimed that multiplex allergen testing may help in diagnosing the cause of symptoms in patients with an unclear cause of allergy or who are allergic to more than one substance.ObjectivesTo evaluate multiplex allergen testing [devices that can measure the presence of multiple immunoglobulin E (IgE) antibodies in a patient’s blood at the same time], by assessing (1) clinical effectiveness (allergy symptoms, incidence of acute exacerbations, mortality, adverse events of testing and treatment, health-care presentations or admissions, health-related quality of life); (2) effects on treatment (diet, immunotherapy medications, other potential testing); (3) any additional diagnostic information provided by multiplex allergen testing; and (4) cost-effectiveness (cost of different assessment strategies).MethodsFifteen databases were searched from 2005 to April 2015, including MEDLINE (via OvidSp), MEDLINE In-Process Citations, MEDLINE Daily Update, PubMed (National Library of Medicine), EMBASE, Cochrane Database of Systematic Reviews (CDSR), Cochrane Central Register of Controlled Trials (CENTRAL), Database of Abstracts of Reviews of Effects (DARE), Health Technology Assessment (HTA) database, Science Citation Index (SCI), Conference Proceedings Citation Index-Science (CPCI-S), BIOSIS Previews, Latin American and Caribbean Health Sciences Literature (LILACS), National Institute for Health Research (NIHR) HTA programme, and the US Food and Drug Administration (FDA); supplementary searches of conference proceedings and trials registries were performed. Review methods followed published guidance from the Cochrane Collaboration and the Centre for Reviews and Dissemination, University of York, UK. The methodological quality of included studies was assessed using appropriate published tools or a review-specific tool designed by the project team. Studies were summarised in a narrative synthesis. Owing to a lack of data on the clinical effectiveness of multiplex allergen testing, no long-term cost-effectiveness model was developed. A conceptual model structure was developed and cost analyses were performed to examine the short-term costs of various possible diagnostic pathways.ResultsFifteen studies were included in the review. The very limited available data indicated that the addition of multiplex allergen testing [ImmunoCAP®Immuno Solid-phase Allergen Chip (ISAC), Thermo Fisher Scientific/Phadia AB, Uppsala, Sweden] to standard diagnostic work-up can change the clinicians’ views on the diagnosis, management and treatment of patients. There was some indication that the use of ImmunoCAP ISAC testing may be useful to guide decisions on the discontinuation of restrictive diets, the content of allergen-specific immunotherapy (SIT) prescriptions, and whether or not patients should receive SIT. However, none of the studies that we identified reported any information on clinical outcomes subsequent to changes in treatment or management. There was some evidence that ImmunoCAP ISAC may be useful for discriminating allergens that are structurally similar and are recognised by the same IgE antibody (cross-immunoreactive). No data were available for Microtest (Microtest Matrices Ltd, London, UK). Detailed cost analyses suggested that multiplex allergen testing would have to result in a substantial reduction of the proportions of patients receiving single IgE testing and oral food challenge tests in order to be cost-saving in the short term.ConclusionsNo recommendations for service provision can be made based on the analyses included in this report. It is suggested that a consensus-based protocol for the use of multiplex allergen testing be developed. The clinical effectiveness and cost-effectiveness of the proposed protocol should then be assessed by comparing long-term clinical and quality of life outcomes and resource use in patients managed using the protocol with those managed using a standard diagnostic pathway.Study registrationThis study is registered as PROSPERO CRD42015019739.FundingThis project was a Diagnostic Assessment Report commissioned by the NIHR HTA programme on behalf of the National Institute for Health and Care Excellence.
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Guérineau, Julie. "Ils combattent l’obsolescence programmée avec un label." DARD/DARD N° 1, no. 1 (November 8, 2019): 118–24. http://dx.doi.org/10.3917/dard.001.0118.
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Dyduch, Jan. "Zadania wiernych świeckich w dokumentach roboczych II Polskiego Synodu Plenarnego." Prawo Kanoniczne 36, no. 3-4 (December 10, 1993): 21–37. http://dx.doi.org/10.21697/pk.1993.36.3-4.02.
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I documenti di lavoro del II Sinodo Plenario della Polonia indicano il programma del rinnovamento della vita religiosa in Polonia. Essi presentano anche il ruolo e i compiti dei laci sulla base dell’insegnamento del Vaticano II. I laici realizzano i loro doveri cristiani partecipando all’attività apostolica, impegnandosi nella vita parrocchiale e diocesana, contribuendo al rinnovamento della vita sociale, politica, economica e culturale del paese. II Sinodo tende, non soltanto a dare il programma per i laici, ma anche a mobilizzare le forze per realizzarlo. A questo scopo servono i documenti di lavoro intensi come le proposte per lo studio, le discussioni, dando le possibilità di riflessione e di attività apostolica e pastorale.
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Tatì, Elisabetta. "Il Programma InvestEU e la Banca europea degli investimenti nella governance economica europea." DIRITTO COSTITUZIONALE, no. 2 (July 2022): 50–62. http://dx.doi.org/10.3280/dc2022-002004.
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Nel contesto del Next Generation EU, un ruolo di primo piano è ricoperto dal nuovo programma InvestEU. Attraverso una rapida analisi del suo regolamento istitutivo, il presente contributo intende ricostruirne la governance e, in particolare, dare conto del ruolo della Banca Europea degli Investimenti (BEI), della Commissione europea e della rete degli istituti nazionali di promozione. Non si tratta certamente di nuove istituzioni ma rinnovato, o rafforzato, appare il loro ruolo nella politica economica dell'Unione, anche alla luce della crisi pandemica. Dopo l'introduzione di cui al paragrafo 1, il paragrafo 2 metterà a confronto il programma InvestEU con il suo predecessore, il c.d. Piano Juncker. Nel paragrafo 3 si analizzerà quindi la governance. Con il paragrafo 4, infine, si tenterà di delineare le conseguenze che tale programma avrà specialmente sul posizionamento della BEI nella governance economica europea.
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Prabhu, Tarun, and William Gropp. "DAME: Runtime-compilation for data movement." International Journal of High Performance Computing Applications 32, no. 5 (April 18, 2017): 760–74. http://dx.doi.org/10.1177/1094342017695444.
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Modern machines consist of multiple compute devices and complex memory hierarchies. For many applications, it is imperative that any data movement between and within the various compute devices be done as efficiently as possible in order to obtain maximum performance. However, hand-optimizing code for one architecture will likely sacrifice both performance portability and software maintainability. In addition, some optimization decisions are best made at runtime. This suggests that the problem ought to be tackled on two fronts. First, provide the programmer with a declarative language to describe data layouts and data motion. This would allow the runtime system to be tuned for each architecture by a specialist and free the programmer to concentrate on the application itself. Second, exploit the execution time information to optimize the data movement code further. MPI derived datatypes accomplish the former task and Just In Time (JIT) compilation can be used for the latter. In this paper, we present DAME—a language and interpreter designed to be used as the backend for MPI derived datatypes. We also present DAME-L and DAME-X, two JIT-enabled implementations of DAME, all of which have been integrated into MPICH. We evaluate their performance on DDTBench and two mini-applications written with MPI derived datatypes and obtain communication speedups of up to 20× and mini-application speedups of up to 3×.
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Grassi, Gaddomaria. "Mental Health Department accreditation. Classification and assessment criteria." Epidemiologia e Psichiatria Sociale 13, no. 2 (June 2004): 126–33. http://dx.doi.org/10.1017/s1121189x00003353.
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SummaryAims – To compare different accreditation categories in Italy and to suggest some criteria to assess them. Methods – The A. compare specific characteristics of different model of normative and professional accreditation and suggest some criteria to distinguish different type of accreditation programme and to assess quality and usefulness of an accreditation programme. Results and Conclusions – Different types of accreditation are attributed to some basic criteria: voluntary/by law, high/low stan- dard, assessment object. Criteria to assess the usefulness are: check list accuracy, support to quality improvement, documental bur- den, services impact.
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Osman, Wan Nadzri, Kamaruddin Radzuan, Faisal Zulhumadi, and Mohd Nasrun Mohd Nawi. "RESEARCH ON THE POTENTIAL FOR ACADEMICIANS TO WORK FROM HOME: RESEARCH IN A MALAYSIAN PUBLIC UNIVERSITY." Journal of Information System and Technology Management 5, no. 18 (September 15, 2020): 61–71. http://dx.doi.org/10.35631/jistm.518006.
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The year 2020 has witnessed the world being swept by the Covid-19 pandemic that has greatly changed the social and economic landscapes of many countries globally. Among the changes brought upon by this pandemic involves the way one works. With the spread of this pandemic, residents in many areas have begun to benefit from the use of various technologies in many activities, including sales and purchase, and performing work in order to minimise from being exposed to activities outside the house. This research was performed with the aim to look at the potential of implementing a work from home programme among the academic staff in a public university in Malaysia. A questionnaire was distributed to observe the feedback regarding the implementation of this programme, and it was revealed that almost all academic staff believed that this programme can be established for academic staff and they stated their readiness to be involved and support the implementation of such a programme.
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Osman, Wan Nadzri, Kamaruddin Radzuan, Faisal Zulhumadi, and Mohd Nasrun Mohd Nawi. "RESEARCH ON THE POTENTIAL FOR ACADEMICIANS TO WORK FROM HOME: RESEARCH IN A MALAYSIAN PUBLIC UNIVERSITY." Journal of Information System and Technology Management 5, no. 19 (December 7, 2020): 93–103. http://dx.doi.org/10.35631/jistm.519008.
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The year 2020 has witnessed the world being swept by the Covid-19 pandemic that has greatly changed the social and economic landscapes of many countries globally. Among the changes brought upon by this pandemic involves the way one works. With the spread of this pandemic, residents in many areas have begun to benefit from the use of various technologies in many activities, including sales and purchase, and performing work in order to minimise from being exposed to activities outside the house. This research was performed with the aim to look at the potential of implementing a work from home programme among the academic staff in a public university in Malaysia. A questionnaire was distributed to observe the feedback regarding the implementation of this programme, and it was revealed that almost all academic staff believed that this programme can be established for academic staff and they stated their readiness to be involved and support the implementation of such a programme.
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Vadnjal, Jaka. "Mehke veščine v visokošolskem izobraževanju." Andragoška spoznanja 19, no. 1 (March 7, 2013): 45. http://dx.doi.org/10.4312/as.19.1.45-57.
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Čeprav Evropska komisija v strateških dokumentih daje vse večji poudarek mehkim veščinam, ki naj bi bile ključne za doseganje ciljev bolonjskega procesa, se zdi, da te veščine še niso našle prave poti v visokošolske izobraževalne programe. Razlog je deloma v tradicionalistični usmeritvi visokošolskega prostora, ki daje prednost znanstvenim podlagam študijskih programov pred njihovo aplikativno vrednostjo. Študija se ukvarja z vprašanjem ključnih mehkih veščin, ki bi jih bilo smiselno povezati s študijskimi programi bodisi kot sestavni del študijskih programov (del modulov ali samostojni modul) bodisi kot zunajštudijskeoblike. Na podlagi raziskave, ki je bila opravljena med kadrovskimi strokovnjaki v šestih državah, je bil prepoznan relativni pomen posameznih mehkih veščin, ki so bile razvrščene v tri ključne skupine: osebne, socialne in metodološko/kontekstualne. V zaključnem delu študije so podani predvideni študijski cilji pri vključevanju mehkih veščin v visokošolske študijske programe.
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Brennan, Kieran, Katrine F. Iversen, Alfonso Blanco-Fernández, Thomas Lund, Torben Plesner, and Margaret M. Mc Gee. "Extracellular Vesicles Isolated from Plasma of Multiple Myeloma Patients Treated with Daratumumab Express CD38, PD-L1, and the Complement Inhibitory Proteins CD55 and CD59." Cells 11, no. 21 (October 25, 2022): 3365. http://dx.doi.org/10.3390/cells11213365.
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Daratumumab (DARA) has improved the outcome of treatment of multiple myeloma (MM). DARA acts via complement-dependent and -independent mechanisms. Resistance to DARA may result from upregulation of the complement inhibitory proteins CD55 and CD59, downregulation of the DARA target CD38 on myeloma cells or altered expression of the checkpoint inhibitor ligand programmed death ligand-1 (PD-L1) or other mechanisms. In this study, EVs were isolated from peripheral blood (PB) and bone marrow (BM) from multiple myeloma (MM) patients treated with DARA and PB of healthy controls. EV size and number and the expression of CD38, CD55, CD59 and PD-L1 as well as the EV markers CD9, CD63, CD81, CD147 were determined by flow cytometry. Results reveal that all patient EV samples express CD38, PD-L1, CD55 and CD59. The level of CD55 and CD59 are elevated on MM PB EVs compared with healthy controls, and the level of PD-L1 on MM PB EVs is higher in patients responding to treatment with DARA. CD147, a marker of various aspects of malignant behaviour of cancer cells and a potential target for therapy, was significantly elevated on MM EVs compared with healthy controls. Furthermore, mass spectrometry data suggests that MM PB EVs bind DARA. This study reveals a MM PB and BM EV protein signatures that may have diagnostic and prognostic value.
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Plourde, Julie. "Un genre en construction : féminité et théâtre à la Congrégation Notre-Dame de Montréal." Cahiers d'histoire 32, no. 1 (November 26, 2013): 35–56. http://dx.doi.org/10.7202/1020230ar.
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Le théâtre et la construction du genre féminin, dans la Congrégation Notre-Dame (CND), semblent avoir été intrinsèquement liés. Genre littéraire pouvant s’exercer à l’oral et s’analyser à l’écrit, le théâtre présentait donc un double intérêt que cette institution éducative sut exploiter afin de former des jeunes filles en accord avec les conventions sociales de l’époque. En examinant l’esprit des fondateurs, en situant le théâtre au sein du programme scolaire et en analysant plusieurs productions écrites de jeunes filles, nous explorerons le pourquoi et le comment de l’utilisation de l’art dramatique par la Congrégation de Notre-Dame. Nous tenterons par là de cerner certaines caractéristiques du genre féminin qui sont transmises à travers cette pratique artistique.
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Csepeli, György. "A mesterséges intelligencia emberi arca." Scientia et Securitas 3, no. 2 (November 10, 2022): 113–17. http://dx.doi.org/10.1556/112.2022.00098.
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Összefoglalás. A cikk az emberi intelligencia és az ember által létrehozott mesterséges intelligencia párhuzamaival, összefonódásaival foglalkozik, áttekintve a mesterséges intelligencia kialakulását a Turing és Neumann által fémjelzett kezdetektől a megismerésben és a cselekvésben az ember versenytársaként fellépő autonóm „Robot sapiens” megjelenéséig. A digitalizáció és a datafikáció által teremtett techno-ökölógiai környezetben az erős mesterségesintelligencia-programok behatolása a társadalomba a rendszerszintű és életvilágszintű működések átalakulását eredményezik. A veszély a machináció létrejöttével a társadalom totális ellenőrzésére alkalmas adatalapú megfigyelő rendszer megjelenésében van, mely a hagyományos diktatúrákkal ellentétben a megfigyeltek aktív közreműködésére épít. A machináció ellenszere a „merj élni!” nietzschei parancsa, mely a létfelejtés által értékek és értelmek keresésére int. Summary. The paper discusses the parallels and confluences between human intelligence and artificial intelligence created by human intelligence. The paper reviews the development of artificial intelligence from the beginnings by the works of Turing and Neumann till the emergence of the autonomous robot sapiens that will likely be in cognition and action challenger of the human being. Artificial intelligence programmes initially were able to solve simple tasks defined by men. Well known examples of the early successes of the artificial intelligence programmes had demonstrated in chess, go and Jeopardy the dominance of these programmes over human intelligence. Programmed by natural language strong artificial intelligence programs able to learn and deal with uncertainty had emerged later. These programmes were successfully connected to the internet based network of people and things. Without strong artificial intelligence programmes no autonomous operation of robots can be expected in cognition and action. In the new techno-ecological environment created by the digitalisation and datafication the intrusion of weak and strong artificial intelligence programmes into the society has resulted profound transformations in the system and in the life-world. Artificial intelligence will likely transform the areas of economy, commerce, transport, politics, culture an education, internal and external security, media and finances. The intelligent autonomous communication bots and action robots change the social life of people including the social and sexual life, enhance the level of services such as health care, and entertainment. All programmes set for the system and life world pass easily the Turing test that raises the problem of the boundaries between human and artificial intelligence. Machines seem as humans and humans seem as machines. The real danger of the digital transformation of society is the emergence of a total surveillance system that in contrast with the dictatorial regimes installs control and repression with the consent of the people using the services of the the digitalised system and life world operations. The threats of the total surveillance system or “machination”, however, can be fended off by fulfilling the command of “Dare to live!” suggested by Friedrich Nietzsche.
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Canainn, Aodh ó. "Massachusetts nua darb ainm Caillimh?Athchultúrú fhochomhlachtaí: Digital Equipment Corporation." Irish Journal of Sociology 5, no. 1 (May 1995): 89–109. http://dx.doi.org/10.1177/079160359500500105.
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This paper examines the acculturation programme which Digital Equipment Corporation has used with success to co-ordinate its world-wide activities. It is critical of the misuse of cultural concepts by some management authors and questions their talk of ‘shared values’. Employees accept the official values of the company as coordinates of work rather than internalising them. In Digital this is not difficult as the declared values are such that most people are happy to accept them as guidelines for management practices. Taking the former hardware manufacturing operation of the Ballybrit factory as an example, the aims of an acculturation programme are examined. The question of whether or not a local culture can be a match for a strong organisational culture is considered. The author concludes that Irish culture is no match for Digital culture in the workplace but that company culture has little or no influence outside it.
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Brook, Angus, Sandra Lynch, and Moira Debono. "Using standards rubrics to assure graduate capabilities within the context of undergraduate liberal arts programmes." Journal of Teaching and Learning for Graduate Employability 4, no. 1 (December 18, 2013): 23–38. http://dx.doi.org/10.21153/jtlge2013vol4no1art559.
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This paper discusses the challenges and opportunities that have arisen out of developing graduate capability standards rubrics for the LOGOS Programme; a liberal education core curriculum programme in philosophy, ethics, and theology that all students at the University of Notre Dame Australia are required to undertake. The paper will focus upon the specific challenges which face liberal education Catholic universities in promoting, fostering and forming graduate attributes amongst their students. In doing so, we will attempt to demonstrate the usefulness of developing standards rubrics as a basis for careful and systematic review of our pedagogical approach, curriculum and assessment design oriented towards assuring graduate attributes and capabilities.
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Baldassarre, Laura, and Chiara Curto. "Garantire i diritti dei bambini e dei minorenni senza alcuna discriminazione: dalle Osservazioni conclusive del Comitato Onu alla sperimentazione in Italia della Garanzia europea per l'Infanzia." MINORIGIUSTIZIA, no. 4 (July 2022): 59–66. http://dx.doi.org/10.3280/mg2021-004007.
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In seguito all'approvazione della Garanzia europea per l'Infanzia da parte del Consiglio dell'Unione Europea nel giugno 2021, la Commissione Europea ha collaborato con l'UNICEF per testare la misura in 7 Paesi dell'Unione, tra cui l'Italia. La Garanzia europea per l'Infanzia è un programma pilota biennale che contribuirà a sviluppare una cornice comune tramite la redazione di Piani Nazionali d'Azione sulla prevenzione e il contrasto della povertà ed esclusione sociale minorile. Da luglio 2020 l'UNICEF sta lavorando col Governo italiano ed altri attori nazionali e locali, incluse le Organizzazioni del Terzo Settore e i bambini stessi, per dare attuazione al programma nell'ambito delle aree e dei beneficiari individuati come prioritari, tra i quali vi sono anche i minorenni con disabilità. In Italia, l'UNICEF in collaborazione col Governo e i partners - sta inoltre supportando il coinvolgimento attivo dei minorenni nei percorsi di redazione, monitoraggio e valutazione d'impatto del Piano Nazionale d'Azione sulla Garanzia Europea, tramite la creazione di uno Youth Advisory Board (YAB) avente funzioni consultive.
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Westwood, M., M. Al, L. Burgers, K. Redekop, S. Lhachimi, N. Armstrong, H. Raatz, K. Misso, J. Severens, and J. Kleijnen. "A systematic review and economic evaluation of new-generation computed tomography scanners for imaging in coronary artery disease and congenital heart disease: Somatom Definition Flash, Aquilion ONE, Brilliance iCT and Discovery CT750 HD." Health Technology Assessment 17, no. 9 (March 2013): 1–243. http://dx.doi.org/10.3310/hta17090.
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BackgroundComputed tomography (CT) is important in diagnosing and managing many conditions, including coronary artery disease (CAD) and congenital heart disease. Current CT scanners can very accurately diagnose CAD requiring revascularisation in most patients. However, imaging technologies have developed rapidly and new-generation computed tomography (NGCCT) scanners may benefit patients who are difficult to image (e.g. obese patients, patients with high or irregular heart beats and patients who have high levels of coronary calcium or a previous stent or bypass graft).ObjectiveTo assess the clinical effectiveness and cost-effectiveness of NGCCT for diagnosing clinically significant CAD in patients who are difficult to image using 64-slice computed tomography and treatment planning in complex congenital heart disease.Data sourcesBibliographic databases were searched from 2000 to February/March 2011, including MEDLINE, MEDLINE In-Process and Other Non-Indexed Citations, EMBASE, Cochrane Database of Systematic Reviews (CDSR), Cochrane Central Register of Controlled Trials (CENTRAL), Database of Abstracts of Reviews of Effects (DARE), NHS Economic Evaluation Database (NHS EED), Health Technology Assessment (HTA) database and Science Citation Index (SCI). Trial registers and conference proceedings were searched.Review methodsSystematic review methods followed published guidance. Risk of bias was assessed using QUADAS-2. Results were stratified by patient group. Summary sensitivity and specificity were calculated using a bivariate summary receiver operating characteristic, or random effects model. Heterogeneity was assessed using the chi-squared statistic andI2-statistic. Cost-effectiveness of NGCCT was modelled separately for suspected and known CAD, evaluating invasive coronary angiography (ICA) only, ICA after positive NGCCT (NGCCT–ICA), and NGCCT only. The cost-effectiveness of NGCCT, compared with 64-slice CT, in reducing imaging-associated radiation in congenital heart disease was assessed.ResultsTwenty-four studies reported accuracy of NGCCT for diagnosing CAD in difficult-to-image patients. No clinical effectiveness studies of NGCCT in congenital heart disease were identified. The pooled per-patient estimates of sensitivity were 97.7% [95% confidence interval (CI) 88.0% to 99.9%], 97.7% (95% CI 93.2% to 99.3%) and 96.0% (95% CI 88.8% to 99.2%) for patients with arrhythmias, high heart rates and previous stent, respectively. The corresponding estimates of specificity were 81.7% (95% CI 71.6% to 89.4%), 86.3% (95% CI 80.2% to 90.7%) and 81.6% (95% CI 74.7% to 87.3%), respectively. In patients with high coronary calcium scores, previous bypass grafts or obesity, only per-segment or per-artery data were available. Sensitivity estimates remained high (> 90% in all but one study). In patients with suspected CAD, the NGCCT-only strategy appeared most cost-effective; the incremental cost-effectiveness ratio (ICER) of NGCCT–ICA compared with NGCCT only was £71,000. In patients with known CAD, the most cost-effective strategy was NGCCT–ICA (highest cost saving, dominates ICA only). The ICER of NGCCT only compared with NGCCT–ICA was £726,230. For radiation exposure only, the ICER for NGCCT compared with 64-slice CT in congenital heart disease ranged from £521,000 for the youngest patients to £90,000 for adults.LimitationsAvailable data were limited, particularly for obese patients and patients with previous bypass grafts. All studies of the accuracy of NGCCT assume that the reference standard (ICA) is 100% sensitive and specific; however, there is some evidence that ICA may sometimes underestimate the extent and severity of stenosis. Patients with more than one criterion that could contribute to difficulty in imaging were often excluded from studies; the effect on test accuracy of multiple difficult to image criteria remains uncertain.ConclusionsNGCCT may be sufficiently accurate to diagnose clinically significant CAD in some or all difficult-to-image patient groups. Economic analyses suggest that NGCCT is likely to be considered cost-effective for difficult-to-image patients with CAD, at current levels of willingness to pay in the NHS. For patients with suspected CAD, NGCCT only would be most favourable; for patients with known CAD, NGCCT–ICA would be most favourable. No studies assessing the effects of NGCCT on therapeutic decision making, or subsequent patient outcomes, were identified. The ideal study to address these questions would be a large multi-centre RCT. However, one possible alternative might be to establish a multicentre tracker study. High-quality test accuracy studies, particularly in obese patients, patients with high coronary calcium, and those with previous bypass grafts are needed to confirm the findings of our systematic review. These studies should include patients with multiple difficult to image criteria.FundingThe National Institute for Health Research Health Technology Assessment programme. This project was funded by the HTA programme, on behalf of NICE, as project number 10/107/01.
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Richardson, Paul G., William Bensinger, Katja C. Weisel, Kevin Boyd, Karthik Ramasamy, Esther Gonzalez, Linda Favre-Kontula, et al. "Durvalumab (DURVA) plus daratumumab (DARA) in patients (pts) with relapsed and refractory multiple myeloma (RRMM)." Journal of Clinical Oncology 35, no. 15_suppl (May 20, 2017): TPS8054. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.tps8054.
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TPS8054 Background: DARA, a monoclonal antibody (mAb) against CD38, is approved for RRMM. Combination treatment (Tx) with DARA + DURVA, a mAb against programmed death ligand-1 (PD-L1), may enhance host anti-MM immunity and response. DARA and PD-L1 mAbs have each demonstrated clinical activity in combination with pomalidomide (POM) + low-dose dexamethasone (LoDEX) in MM. Thus, the phase 2 MEDI4736-MM-003 trial is evaluating DURVA + DARA in RRMM, and, in an exploratory analysis, the addition of POM + LoDEX to DARA + DURVA either upon progressive disease (PD) with DARA + DURVA or as up-front Tx will be assessed. Methods: ≈ 144 pts with RRMM are being enrolled. Pts with measurable MM who received ≥ 3 prior anti-MM Txs, including a protease inhibitor and an immunomodulatory agent, or are double-refractory to these 2 agents will be included. Exclusion criteria include allogeneic stem cell transplant (SCT), autologous SCT ≤ 12 weeks, and prior DARA or other CD38 antibody therapies. Primary endpoints are overall response rate (ORR) and safety. Secondary endpoints are time to response, duration of response, progression-free survival, and pharmacokinetics. The study includes a 3 + 3 safety run-in phase to confirm the tolerability of the recommended phase 2 doses (RP2Ds) of DURVA and DARA. Dose-limiting toxicities will be evaluated during the first Tx cycle. Safety and efficacy will be assessed by a Simon 2-stage design (Table). POM + LoDEX may be added to DARA + DURVA in pts who received ≥ 2 cycles of DARA + DURVA and had confirmed PD. Based on preliminary safety and efficacy, the 4-drug regimen may be explored as up-front Tx. Tx with either the 2- or 4-drug regimens will continue until PD or unacceptable toxicity. Pts treated with POM will be followed for second primary malignancies every 6 mos until the end of the trial. To date, 6 pts have enrolled in the run-in phase. Clinical trial information: NCT02807454. [Table: see text]
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Wade, R., E. Spackman, M. Corbett, S. Walker, K. Light, R. Naik, M. Sculpher, and A. Eastwood. "Adjunctive colposcopy technologies for examination of the uterine cervix – DySIS, LuViva Advanced Cervical Scan and Niris Imaging System: a systematic review and economic evaluation." Health Technology Assessment 17, no. 8 (March 2013): i—239. http://dx.doi.org/10.3310/hta17080.
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BackgroundWomen in England (aged 25–64 years) are invited for cervical screening every 3–5 years to assess for cervical intraepithelial neoplasia (CIN) or cancer. CIN is a term describing abnormal changes in the cells of the cervix, ranging from CIN1 to CIN3, which is precancerous. Colposcopy is used to visualise the cervix. Three adjunctive colposcopy technologies for examination of the cervix have been included in this assessment: Dynamic Spectral Imaging System (DySIS), the LuViva Advanced Cervical Scan and the Niris Imaging System.ObjectiveTo determine the clinical effectiveness and cost-effectiveness of adjunctive colposcopy technologies for examination of the uterine cervix for patients referred for colposcopy through the NHS Cervical Screening Programme.Data sourcesSixteen electronic databases [Allied and Complementary Medicine Database (AMED), BIOSIS Previews, Cochrane Database of Systematic Reviews (CDSR), Cochrane Central Register of Controlled Trials (CENTRAL), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Database of Abstracts of Reviews of Effects (DARE), EMBASE, Health Management Information Consortium (HMIC), Health Technology Assessment (HTA) database; Inspec, Inside Conferences, MEDLINE, NHS Economic Evaluation Database (NHS EED), PASCAL, Science Citation Index Expanded (SCIE) and Science Citation Index (SCI) – Conference Proceedings], and two clinical trial registries [ClinicalTrials.gov and Current Controlled Trials (CCT)] were searched to September–October 2011.Review methodsStudies comparing DySIS, LuViva or Niris with conventional colposcopy were sought; a narrative synthesis was undertaken. A decision-analytic model was developed, which measured outcomes in terms of quality-adjusted life-years (QALYs) and costs were evaluated from the perspective of the NHS and Personal Social Services with a time horizon of 50 years.ResultsSix studies were included: two studies of DySIS, one study of LuViva and three studies of Niris. The DySIS studies were well reported and had a low risk of bias; they found higher sensitivity with DySIS (both the DySISmap alone and in combination with colposcopy) than colposcopy alone for identifying CIN2+ disease, although specificity was lower with DySIS. The studies of LuViva and Niris were poorly reported and had limitations, which indicated that their results were subject to a high risk of bias; the results of these studies cannot be considered reliable. The base-case cost-effectiveness analysis suggests that both DySIS treatment options are less costly and more effective than colposcopy alone in the overall weighted population; these results were robust to the ranges tested in the sensitivity analysis. DySISmap alone was more costly and more effective in several of the referral groups but the incremental cost-effectiveness ratio (ICER) was never higher than £1687 per QALY. DySIS plus colposcopy was less costly and more effective in all reasons for referral. Only indicative analyses were carried out on Niris and LuViva and no conclusions could be made on their cost-effectiveness.LimitationsThe assessment is limited by the available evidence on the new technologies, natural history of the disease area and current treatment patterns.ConclusionsDySIS, particularly in combination with colposcopy, has higher sensitivity than colposcopy alone. There is no reliable evidence on the clinical effectiveness of LuViva and Niris. DySIS plus colposcopy appears to be less costly and more effective than both the DySISmap alone and colposcopy alone; these results were robust to the sensitivity analyses undertaken. Given the lack of reliable evidence on LuViva and Niris, no conclusions on their potential cost-effectiveness can be drawn. There is some uncertainty about how generalisable these findings will be to the population of women referred for colposcopy in the future, owing to the introduction of the human papillomavirus (HPV) triage test and uptake of the HPV vaccine.Study registrationPROSPERO Record CRD42011001614.FundingThe National Institute for Health Research Health Technology Assessment programme.
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O’Mara-Eves, A., G. Brunton, D. McDaid, S. Oliver, J. Kavanagh, F. Jamal, T. Matosevic, A. Harden, and J. Thomas. "Community engagement to reduce inequalities in health: a systematic review, meta-analysis and economic analysis." Public Health Research 1, no. 4 (November 2013): 1–526. http://dx.doi.org/10.3310/phr01040.
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BackgroundCommunity engagement has been advanced as a promising way of improving health and reducing health inequalities; however, the approach is not yet supported by a strong evidence base.ObjectivesTo undertake a multimethod systematic review which builds on the evidence that underpins the current UK guidance on community engagement; to identify theoretical models underpinning community engagement; to explore mechanisms and contexts through which communities are engaged; to identify community engagement approaches that are effective in reducing health inequalities, under what circumstances and for whom; and to determine the processes and costs associated with their implementation.Data sourcesDatabases including the Cochrane Database of Systematic Reviews (CDSR), The Campbell Library, the Database of Abstracts of Reviews of Effects (DARE), the Health Technology Assessment (HTA) database, the NHS Economic Evaluation Database (NHS EED) and EPPI-Centre’s Trials Register of Promoting Health Interventions (TRoPHI) and Database of Promoting Health Effectiveness Reviews (DoPHER) were searched from 1990 to August 2011 for systematic reviews and primary studies. Trials evaluating community engagement interventions reporting health outcomes were included.Review methodsStudy eligibility criteria: published after 1990; outcome, economic, or process evaluation; intervention relevant to community engagement; written in English; measured and reported health or community outcomes, or presents cost, resource, or implementation data characterises study populations or reports differential impacts in terms of social determinants of health; conducted in an Organisation for Economic Co-operation and Development (OECD) country. Study appraisal: risk of bias for outcome evaluations; assessment of validity and relevance for process evaluations; comparison against an economic evaluation checklist for economic evaluations. Synthesis methods: four synthesis approaches were adopted for the different evidence types: theoretical, quantitative, process, and economic evidence.ResultsThe theoretical synthesis identified key models of community engagement that are underpinned by different theories of changes. Results from 131 studies included in a meta-analysis indicate that there is solid evidence that community engagement interventions have a positive impact on health behaviours, health consequences, self-efficacy and perceived social support outcomes, across various conditions. There is insufficient evidence – particularly for long-term outcomes and indirect beneficiaries – to determine whether one particular model of community engagement is likely to be more effective than any other. There are also insufficient data to test the effects on health inequalities, although there is some evidence to suggest that interventions that improve social inequalities (as measured by social support) also improve health behaviours. There is weak evidence from the effectiveness and process evaluations that certain implementation factors may affect intervention success. From the economic analysis, there is weak but inconsistent evidence that community engagement interventions are cost-effective. By combining findings across the syntheses, we produced a new conceptual framework.LimitationsDifferences in the populations, intervention approaches and health outcomes made it difficult to pinpoint specific strategies for intervention effectiveness. The syntheses of process and economic evidence were limited by the small (generally not rigorous) evidence base.ConclusionsCommunity engagement interventions are effective across a wide range of contexts and using a variety of mechanisms. Public health initiatives should incorporate community engagement into intervention design. Evaluations should place greater emphasis on long-term outcomes, outcomes for indirect beneficiaries, process evaluation, and reporting costs and resources data. The theories of change identified and the newly developed conceptual framework are useful tools for researchers and practitioners. We identified trends in the evidence that could provide useful directions for future intervention design and evaluation.FundingThe National Institute for Health Research Public Health Research programme.
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Smith, Toby O., Oluseyi F. Jimoh, Jane Cross, Louise Allan, Anne Corbett, Euan Sadler, Mizanur Khondoker, Jennifer Whitty, Jose M. Valderas, and Christopher Fox. "Social Prescribing Programmes to Prevent or Delay Frailty in Community-Dwelling Older Adults." Geriatrics 4, no. 4 (November 27, 2019): 65. http://dx.doi.org/10.3390/geriatrics4040065.
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The increasing incidence of frailty is a health and social care challenge. Social prescription is advocated as an important approach to allow health professionals to link patients with sources of support in the community. This study aimed to determine the current evidence on the effectiveness of social prescribing programmes, to delay or reduce frailty in frail older adults living in the community. A systematic literature review of published (DARE, Cochrane Database of Systematic Reviews, MEDLINE, EMBASE, CINAHL, NICE and SCIE, National Health Service (NHS) Economic Evaluation Database) and unpublished databases (OpenGrey; WHO Clinical Trial Registry; ClinicalTrials.gov) were searched to July 2019. Studies were eligible if they reported health, social or economic outcomes on social prescribing, community referral, referral schemes, wellbeing programmes or interventions when a non-health link worker was the intervention provider, to people who are frail living in the community. We screened 1079 unique studies for eligibility. No papers were eligible. There is therefore a paucity of evidence reporting the effectiveness of social prescribing programmes for frail older adults living in the community. Given that frailty is a clinical priority and social prescribing is considered a key future direction in the provision of community care, this is a major limitation.
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Bernhart, Toni, and Sandra Richter. "Frühe digitale Poesie." Informatik Spektrum 44, no. 1 (February 2021): 11–18. http://dx.doi.org/10.1007/s00287-021-01329-z.
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ZusammenfassungDie Idee, Poesie maschinell zu generieren, ist so alt wie die Maschinen selbst. Sie lässt sich seit dem Mittelalter beobachten und setzt sich fort bis in die Gegenwart, in der Storytelling-Experimente Algorithmen zur natürlichsprachigen Textgenerierung (NLG) nutzen. Die weltweit ersten Versuche, Poesie digital herzustellen, gelangen in den 1950er Jahren den Mathematikern Christopher Strachey (1916–1975) in Manchester und Theo Lutz (1932–2010) in Stuttgart. Durch zufallsmäßige Auswahl passfähiger Wörter und Sätze erzeugte Strachey 1952 auf einer Ferranti Mark I kurze Liebesbriefe. Dazu verwendete er das Programmierhandbuch von Alan Turing (1912–1954). Daneben schrieb Strachey Programme für das Dame-Spiel und zur computationellen Erzeugung von Musik. Lutz stellte 1959 mithilfe eines Programms im Freiburger Code auf einer Zuse Z 22 seine Stochastischen Texte her, wofür er Wortmaterial aus Franz Kafkas Roman Das Schloss (1926) verwendete und wobei er mit dem Philosophen Max Bense (1910–1990) und dem späteren Informatik-Pionier Rul Gunzenhäuser (1933–2018) kooperierte. Weil Lutz’ Arbeitsunterlagen nahezu vollständig erhalten und im Deutschen Literaturarchiv Marbach für die Forschung zugänglich sind, gilt Lutz als ein literatur- und informatikgeschichtlich bedeutsamer Vertreter früher digitaler Poesie, die lange Zeit fast nur in avantgardistischen Zirkeln diskutiert wurde und kaum den Weg in eine breitere Öffentlichkeit fand. Erst aktuelle Debatten um sogenannte Künstliche Intelligenz (KI) lenken wieder die Aufmerksamkeit auf diese frühen Experimente, die ein faszinierender Mosaikstein der Technik‑, Kultur- und Literaturgeschichte sind.
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Calza Bini, Paolo, and Caterina Cortese. "Sistemi di regolazione locale in una prospettiva di governance: proposte per l'analisi." ARGOMENTI, no. 33 (December 2011): 51–73. http://dx.doi.org/10.3280/arg2011-033003.
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Il saggio propone una rivisitazione del concetto di governance al fine di analizzare la sua validitŕ come modello per l'analisi dei sistemi locali di sviluppo. La riflessione inizia evidenziando le continuitŕ che esso dimostra di avere con sistemi pregressi di regolazione locale (modello distrettuale) nei quali i fattori socio-relazionali rappresentavano l'anello forte dello sviluppo e si conclude proponendo di utilizzare il modello di governance per osservare gli impatti socio-economici dei piů recenti programmi integrati territoriali. Tra limiti e opportunitŕ, gli autori convergeranno nell'osservare come l'utilizzo di una prospettiva propria della sociologia economica nello studio della governance locale possa rappresentare un'occasione per continuare a dare un'attenzione specifica alla dimensione meso (istituzioni) e micro (attori) dei processi che entrano nelle dinamiche dello sviluppo locale studiandone il sistema di relazioni e le pratiche di coordinamento.
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Clark-Burg, Karen. "Future Perioperative Registered Nurses: An Insight into a Perioperative Programme for Undergraduate Nursing Students." Journal of Perioperative Practice 18, no. 10 (October 2008): 432–35. http://dx.doi.org/10.1177/175045890801801001.
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An Australian College of Operating Room Nurses (ACORN) submission (ACORN 2002–2008) recently stated that the specialities that suffered significantly from the transition of hospital-based nursing training to university training were the perioperative specialty, critical care and emergency. The main reason for this was that perioperative nursing was not included in the undergraduate nursing curriculum. Less than a handful of universities in Australia offer the subject as a compulsory unit. The University of Notre Dame Australia (UNDA) is one of these universities. This paper will provide an insight into the perioperative nursing care unit embedded within the Bachelor of Nursing (BN) undergraduate curriculum.
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Shearer, James, Hiong Tie, and Sarah Byford. "Economic evaluations of contingency management in illicit drug misuse programmes: A systematic review." Drug and Alcohol Review 34, no. 3 (February 8, 2015): 289–98. http://dx.doi.org/10.1111/dar.12240.
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Ikase, Laila, Inese Drudze, and Gunārs Lācis. "Current Achievements of the Latvian Apple Breeding Programme." Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences. 76, no. 4 (August 1, 2022): 424–31. http://dx.doi.org/10.2478/prolas-2022-0066.
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Abstract The commercial apple growing industry in Latvia has a lack of climate adapted modern cultivars. The Latvian apple breeding programme is targeted at cultivars adapted to the cool climate of Baltic countries and Scandinavia, with fruit quality and storage suitable for commercial production. Since 1989, scab resistance (Rvi6, Rvi5) donors are included in crosses. Several cultivars already show commercial promise — ‘Dace’, ‘Gita’, ’Monta’ (Rvi6) and the polygenic resistant ‘Laila’ and ‘Pure Ametist’. However, in 2020, the Rvi6 resistance was overcome in Latvia. Donors of polygenic scab tolerance may prove a better alternative. The most successful donors have been ‘Iedzēnu’, ‘Eksotika’, ‘Alesya’, and ‘Bohemia’. Marker assisted gene pyramiding was started, including markers linked to the resistance genes Rvi5 and Rvi6. Scab resistant cultivars ‘Edite’, ‘Felicita’, ‘Ligita’, and ‘Paulis’ show low susceptibility to Neonectria ditissima canker. To achieve high fruit quality and good storage, worldwide commercial cultivars are crossed with local adapted cultivars. Such crosses that have been registered include ‘Inta’, ‘Lora’, and ‘Saulesmeita’. Recent crosses for quality include ‘Honeycrisp’, where H-1-07-36 and H-1-07-42 show most promise. Improved biochemical content and flesh structure is one of the main targets. An additional line of breeding is aimed at ornamental and cider apples. The scab resistant Nr.19-97-154 (Cidross) was selected for cider. The red leaf columnar apple ‘Karlens’ and the compact red-leaf crab ‘Auce’ have been registered.
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Isaacs, Marie E. "Hebrews 13.9–16 Revisited." New Testament Studies 43, no. 2 (April 1997): 268–84. http://dx.doi.org/10.1017/s0028688500023262.
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Many years ago I watched a television programme on the art of acting. It was a ‘Masterclass’ conducted by Dame Flora Robson. She took a group of Royal Academy of Dramatic Arts’ students, divided them into four separate groups, and then asked each to act out a scene. Each separate cast was given the same script, but, unbeknown to the others, each group was given an entirely different background to the setting of the scene. We then saw the results; four readings, each with the same lines but understood completely differently.
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Pillai, Rathi Narayana, Suresh S. Ramalingam, David P. Carbone, Luis G. Paz-Ares, Meena Thayu, Patricia Watson, Nushmia Z. Khokhar, and Martin Reck. "Randomized, open-label phase Ib/II study of atezolizumab with or without daratumumab in previously treated advanced or metastatic non-small cell lung cancer (NSCLC)." Journal of Clinical Oncology 35, no. 15_suppl (May 20, 2017): TPS9102. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.tps9102.
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TPS9102 Background: Daratumumab (DARA), a human CD38 monoclonal antibody, is approved for treatment of relapsed/refractory multiple myeloma (RRMM). DARA produces deep clinical responses in RRMM and induces T-cell expansion through reduction of immune suppressive cell populations (CD38+ myeloid-derived suppressor cells and regulatory T and B cells). Atezolizumab (atezo) blocks programmed death-ligand 1 (PD-L1) and was recently approved for metastatic NSCLC that progressed on or during platinum therapy based on data showing improved overall survival (OS) in the atezo vs docetaxel treatment arm. A combination of DARA and atezo may improve clinical responses in NSCLC by enhancing anti-tumor T-cell responses facilitated by checkpoint inhibition. This study will assess the anti-tumor activity and safety profile of DARA plus atezo vs atezo alone in patients (pts) with previously treated advanced or metastatic NSCLC. Methods: This is an ongoing phase 1b/2 randomized, open-label, multicenter study of atezo (1200 mg intravenous [IV]; Day 2 of Cycle 1 and Day 1 of each 21-day cycle thereafter) alone or in combination with DARA (16 mg/kg IV weekly for 3 cycles [Days 1, 8, and 15] and then Day 1 of each 21-day cycle thereafter). Eligible pts (≥18 years) must have advanced or metastatic NSCLC and received standard platinum-based therapy with disease progression or intolerance to therapy. ECOG performance status of ≤1 and known PD-L1 tumor status are required. Pts previously treated with anti-CD38 therapy, including DARA, CD137 agonists, or immune checkpoint inhibitors are excluded. The primary endpoint is overall response rate. Secondary outcomes include safety, duration of response, clinical benefit rate (≥16 weeks duration), progression-free survival, OS, and pharmacokinetics and immunogenicity of DARA and atezo when given in combination. Approximately 96 pts will be enrolled; 6 pts will receive combination therapy in a safety run-in cohort for evaluation of dose-limiting toxicity followed by 90 pts randomly (1:1) assigned to the 2 treatments. Clinical trial information: NCT03023423.
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Thibodeau-Gervais, Suzanne, Daniel Latulippe, and Claudette Vincent. "Réinsertion sociale : programme d’action pour permettre aux patients psychiatriques d’acquérir des habiletés fonctionnelles et relationnelles." Santé mentale au Québec 19, no. 1 (September 11, 2007): 145–56. http://dx.doi.org/10.7202/032300ar.
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RÉSUMÉ Depuis l'élaboration de nouvelles politiques en matière de santé mentale, un rapprochement avec le milieu communautaire s'amorce pour faciliter le processus de réinsertion sociale des personnes ayant des problèmes psychiatriques. Cet article décrit un projet d'intervention pour favoriser le développement d'habiletés fonctionnelles et relationnelles des malades dans un milieu parahospitalier: les appartements supervisés. L'objectif de cette action est de favoriser chez l'individu une réflexion sur sa situation et surtout lui permettre d'acquérir et d'expérimenter un certain savoir-faire pour s'intégrer dans son milieu. Ce projet d'intervention a été réalisé par le service social psychiatrique de l'hôpital Notre-Dame, département de psychiatrie et Maison l'Échelon Inc., organisme sans but lucratif gérant des groupes d'appartements supervisés pour des patients psychiatriques.
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Strapko, Michal, and Radek Tichánek. "Engine control unit based on the Ni compactrio platform." Journal of Middle European Construction and Design of Cars 9, no. 3 (December 1, 2011): 47–54. http://dx.doi.org/10.2478/v10138-011-0019-8.
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SHRNUTÍ Byla vyvinuta programovatelna řidici jednotka na platformě CompactRIO s programem vytvořenym v prostředi LabVIEW. Jednotka byla vyvijena jako univerzalni a byla testovana při řizeni maleho zažehoveho motoru YAMAHA YZF R6. Jednotka je dale použitelna pro zažehove motory různe koncepce, přeplňovane i nepřeplňovane. Požadavku na univerzalnost jednotky byl přizpůsoben řidici program, ktery je uspořadan ve vzajemně komunikujicich samostatnych blocich. Zařizeni je rozšiřitelne o dalši I/O moduly, což umožňuje použiti dalšich snimačů, aktuatorů nebo modulů pro komunikaci. Rozhrani pro zesileni vystupů napajejicich zapalovani a vstřikovače bylo vyvinuto pro řizeni motoru YAMAHA YZF R6. Toto zařizeni zaroveň stabilizuje napajeni snimačů motoru a filtruje jejich vystupni signaly. Članek je shrnutim procesu vyvoje řidici jednotky motoru, obsahuje přehled použitych zařizeni, seznamuje s řidicim programem a zkušenostmi z testovani na motoru.
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Singh, Naresh. "Reidar Dale: ‘People’s Development Through People’s Institutions: The Social Mobilisation Programme Hambantota, Sri Lanka’." AI & SOCIETY 21, no. 3 (June 30, 2006): 383–85. http://dx.doi.org/10.1007/s00146-006-0055-4.
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Fischer, Jane A., Ann M. Roche, and Victoria Kostadinov. "Operationalising the quality of life construct in studies of alcohol and drug residential rehabilitation programme clients: A systematic review." Drug and Alcohol Review 38, no. 6 (September 2019): 674–89. http://dx.doi.org/10.1111/dar.12981.
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