Dissertations / Theses on the topic 'DAPL'
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Dew, Robert, and mikewood@deakin edu au. "The development of DAL and DAPL languages for building distributed applications." Deakin University. School of Information Technology, 2002. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20050826.101627.
Full textGaston, Emilia. "Framing a Sacred Fight: Framing Analysis and Collective Identity of the #noDAPL Movement." Thesis, University of North Texas, 2020. https://digital.library.unt.edu/ark:/67531/metadc1703426/.
Full textChou, Danielle 1981. "Dahl friction modeling." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/32826.
Full textIncludes bibliographical references (p. 22).
The drive behind improved friction models has been better prediction and control of dynamic systems. The earliest model was of classical Coulomb friction; however, the discontinuity during force reversal of the Coulomb friction model has long been a point of contention since such a discontinuity does not accurately portray the behavior of real systems. Other models have been suggested, but variations of the Dahl solid friction model remain some of the simplest yet most useful. Dahl's original theory proposed that friction behaved as a stress acting upon the quantum mechanical bonds at the interface. Thus, the relationship between frictional force and position would be analogous to a stress-strain curve, complete with hysteresis should there be permanent displacement akin to plastic deformation in materials. This project reviews the variations of Dahl friction models popular in the literature and then demonstrates it both analytically via Matlab and Simulink simulations and experimentally by observing the behavior of a limited angle torque motor.
by Danielle Chou.
S.B.
Lin, Yao. "Control of DAPK-1 degradation." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4189.
Full textTerwilliger, Miranda Lilian Naeser. "Population and habitat analyses for Dall's sheep (Ovis dalli) in Wrangell-St. Elias National Park and Preserve." PURL, 2005. http://www.arlis.org/docs/vol1/71013833.pdf.
Full textFlynn, Patrick G. "Activation of Non-Muscle Myosin IIB Helps Mediate TNF-Alpha Cell Death Signaling." Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_dissertations/369.
Full textPunzet, Robert. "99mTc-HYNIC-DAPI-DNA-Bindungsnachweis und Nachweis von DNA-Doppelstrangbrüchen durch 99mTc-HYNIC-DAPI mittels Agarose-Gelelektrophorese." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-146456.
Full textIntroduction and aim of the study: A radionuclide commonly used in diagnostic nuclear medicine is 99mTc. It emits gamma rays with a relatively low energy (140 keV) and has a short half-time (6h). In addition to gamma rays, 99mTc radiates so called Auger-electrons with low energy, low range and high linear energy transfer. Due to the high-LET Auger-electrons have a sufficient energy deposition to induce direct double-strand breaks to the DNA. In these experiments we used plasmid DNA to evaluate damage induced to biological systems by different chemotoxical substances and radionuclides as well as external radiation. By using plasmids instead of cell cultures we avoid lots of unexplored signal pathways in cells and it is possible to quantify chemotoxical and radiation damage to the DNA. Materials and methods: The double-stranded plasmid pUC 19 with 2686 bp is used in all experiments. It is a synthetically produced bacterial plasmid without any proteins. To distinguish between directly and indirectly (radical induced) induced damage we used the radical scavenger DMSO. Indirectly induced damage via reactive oxygen species (ROS) can be prevented by DMSO. The quantification of supercoiled forms, single strand breaks (SSB) and double strand breaks (DSB) was measured by the method of agarose gel electrophoresis. After the electrophoresis, agarose gels are dyed in ethidium bromide and imaged with a ccd-camera using ultraviolet transillumination. The bands of the different plasmid forms were quantified through the FIJI computer program. Results: First of all a correlation between plasmid mass and fluorescence intensity was shown. In a pretrial no damaging effect to the plasmid from incubation temperature, pH-value and radical scavenger DMSO appeared. Afterwards we examined chemotoxical SnCl2, external x-rays, the alpha emitter 223Ra, the beta emitter 188Re, gamma- and Auger-emitter 99mTc and the DNA-bound 99mTc-HYNIC-DAPI. The radical scavenger DMSO was used to differentiate between indirect (radical induced) and direct DNA-damage. All different radiation qualities showed an increasing DNA-damage with increasing energy dose. For the low-LET radiation qualities like chemotoxical SnCl2, external x-rays, the beta emitter 188Re and not DNA-bound 99mTc, DMSO showed the quality to prevent the damage. After the deposition of an energy dose ≥ 600 Gy DMSO showed a limitation in his scavenger capacity. During radiation with high-LET beams like 223Ra or DNA-bound 99mTc-HYNIC-DAPI DMSO showed less or nearly no ability to prevent DNA-damage. A 4 Gy dose of 99mTc-HYNIC-DAPI was able to induce DSB into the plasmid. These DSB could not be prevented by DMSO. The lower ESB:DSB ratio for high-LET beams also displays that direct damage is more likely to create DSB than indirect damage. Conclusion: In conclusion we can say that DNA-bound 99mTc-HYNIC-DAPI was most appropriate to induce DSB via a direct effect. It was impossible to prevent this damage due to adding the 69 radical scavenger DMSO. We attribute this to low range, low-LET Auger-electrons and suppose that it may be possible to use DNA-bound 99mTc for therapeutic purpose. Further research has to show if 99mTc can be targeted to the DNA of intact cells and if suitable tracers can be found to safely target and kill tumor cells
Smith, Joel W. S. "Investigating the mechanism of translational stimulation by Deleted in Azoospermia-like." Thesis, University of Edinburgh, 2008. http://hdl.handle.net/1842/4849.
Full textCarnino, Cecilia. "Dal lusso al consumo." Paris 1, 2012. http://www.theses.fr/2012PA010602.
Full textEdwards, Jennifer Somerville 1967. "Louise Dahl-Wolfe: A fashion photographer redefined." Thesis, The University of Arizona, 1996. http://hdl.handle.net/10150/291450.
Full textGill, Mark E. "Dazl regulates mouse embryonic germ cell development." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/58372.
Full textCataloged from PDF version of thesis.
Includes bibliographical references.
In the mouse, germ cells can undergo differentiation to become either oocytes or spermatozoa in response to sex of their gonadal environment. The nature of the germ cell-intrinsic aspects of this signaling have not been well studied. The earliest known sex-specific difference in germ cells is the initiation of meiosis in female, but not male, embryonic germ cells. Experiments were performed showing that germ cells of both sexes transit through a state, the meiosis competent germ cell, that is required for initiation of meiosis. Acquisition of this state requires the function of the germ cellspecific RNA binding protein DAZL. The sufficiency for the absence of meiosis to drive male germ cell differentiation was then tested by examining non-meiotic XX germ cells in the Dazl-deficient ovary. These cells did not exhibit male differentiation indicating that the absence of meiosis is not sufficient for male differentiation. XX Dazl-deficient germ cells also failed to exhibit normal female differentiation. In addition, XY Dazl-deficient germ cells do not display characteristics of either male or female germ cells. Taken together, these results indicate that germ cells must first undergo a sex non-specific differentiation step prior to acquiring sexual fate.
by Mark E. Gill.
Ph.D.
Barros, Leila de Almeida. "Darl, o homem de gênio em Faulkner." Universidade Estadual de Londrina. Centro de Letras e Ciências Humanas. Programa de Pós-Graduação em Letras, 2014. http://www.bibliotecadigital.uel.br/document/?code=vtls000194230.
Full textConsidered by critics as one of the most enigmatic creations of William Faulkner, the character Darl Bundren in As I Lay Dying (1930) is here examined in the light of the thought of the German philosopher Arthur Schopenhauer, especially with regard to the notion of the genius as presented in the third book of The World as Will and Representation (1819). In As I Lay Dying, the author takes to the extreme his fictional experimentations through 59 monologues of fifteen narrators who take turns to tell the journey of the Bundren family, in which they participate directly or indirectly. In a wagon, the family of small farmers carries the corpse of their matriarch to Jefferson, the capital of the fictional Yoknapatawpha County, in order to fulfill the promise to bury her with the rest of her family. Later on, it is observed that what might be called a genuine odyssey is not finished by most of the Bundrens for honor of the memory of the mother, but because of their personal ambitions. While the other Bundrens, in schopenhaeurian terms, remain trapped in the world of concept and abstraction, Darl contemplates the same objects for their truth, disregarding the superficial reflection on the utility that they would have in the phenomenal world. Thus, the character could be compared to the genius, the pure subject of knowing (SCHOPENHAUER, 2005, p. 254), the only one who has an artistic sensibility and surrenders to his tragic destiny because the world to which his family is confined is not his world (FAULKNER, 2002, p. 223). In order to make this approximation between Schopenhauer's thought and the Faulknerian hero, this dissertation is divided into four chapters. The introductory chapter briefly discusses the American modernist movement, its historical context, the problems addressed in it, and its diversity of themes. In addition, it discusses Faulkners context of production, with an extensive literature review on the specificities of his work and his main literary concerns. A literature review of As I Lay Dying is offered in the first chapter. In the second one, a description of The World is presented in order to better understand the theory of the genius. Here, the objective is also to connect Schopenhauer's philosophy to the work of Faulkner through the discussion of works that have managed to intersect one or another of his aesthetic concerns to the premises of the Frankfurt philosopher. Finally, in the third chapter, an analysis of the novel from the schopenhauerian notion of the genius is performed.
Herndon, Karlie E. "Food and power in Roald Dahl's James and the giant peach and Neil Gaiman's Coraline." View electronic thesis (PDF), 2009. http://dl.uncw.edu/etd/2009-1/herndonk/karlieherndon.pdf.
Full textBanna, Christopher David. "Characterization of DAP1/YPL170W: the Saccharomyces cerevisiae Membrane Associated Progesterone Receptor (MAPR)Homologue." Diss., Georgia Institute of Technology, 2005. http://hdl.handle.net/1853/6826.
Full textGhia, Guido. "Fichte nella teologia : dall'"Atheismusstreit" ai giorni nostri /." Milano : Guerini e associati, 2003. http://catalogue.bnf.fr/ark:/12148/cb39177994k.
Full textNotes bibliogr.
Rosa, Cayo Candido. "Gustavo Dahl e a Embrafilme: discurso e prática." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/8/8138/tde-12122016-111021/.
Full textThis study aims to analyse the life of Gustavo Dahl focusing in the 1960s and 1970s when he acted as a filmmaker, film critic and manager of Embrafilme (Empresa Brasileira de Filmes S/A). Taking into consideration the turbulent historical context ranging from the year before and during the military rule in Brazil, we try to understand how his ideas and articles written throughout the years in questions were put into practice when he was responsible for the distribution of films at the state company also taking into consideration his conception of market and his influences in the cinema fields and also in the high levels of power.
Bozzato, Luca. "Metodi perturbativi dipendenti dal tempo." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amslaurea.unibo.it/7682/.
Full textBertozzi, Michela. "Proposta di traduzione dal tedesco di quattro arie dal Singspiel "Die Zauberflöte" di W.A. Mozart." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2019.
Find full textGao, Yong. "Synthesis of diaminopimelic acid (DAP) and analogues, mechanistic studies on dap aminotransferase, epimerase and dehydrogenase." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ34768.pdf.
Full textBetke, Anja. "Roald Dahl: schwarzer Humor in der Kinder- und Jugendliteratur." [S.l. : s.n.], 2003. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB11675655.
Full textSequeira, Joana Brito. "Estudo epidemiológico de espécies de Culicoides capturados perto de equinos no noroeste da Alemanha." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2020. http://hdl.handle.net/10400.5/20421.
Full textO cavalo é um animal muito importante na cultura e na economia alemã, sendo várias as utilizações do equino neste país, assim como as oportunidades de negócio ligadas ao setor equestre. As diferentes doenças que podem afetar estes animais têm, um impacto direto nos seus proprietários, principalmente a nível económico. De entre várias doenças que podem afetar os equinos, pode-se mencionar a dermatite alérgica à picada de Culicoides (DAPC) ou hipersensibilidade à picada de insetos (HPI). Os objetivos deste trabalho foram perceber quais as espécies de Culicoides presentes perto de equinos no noroeste da Alemanha e qual a proporção de DAPC na mesma área. Os insetos foram capturados em sete locais diferentes, no estado de Nordrhein Westfalen, Alemanha, com recurso a armadilhas do tipo miniature CDC light trap, num total de 30 capturas, tendo sido registados todos os fatores bióticos e abióticos observados durante os períodos de captura, entre 26 de setembro e 15 de dezembro de 2019. Foram também distribuídos panfletos informativos e questionários a tutores de equinos, para avaliar a proporção de DAPC nesta área, as alturas do ano em que a mesma se manifesta e como eram mantidos os animais afetados, assim como perceber o impacto desta doença ao nível do desempenho do equino e o impacto económico da mesma para os tutores. Um total de 195 insetos foram capturados perto de equinos, tendo sido identificadas as seguintes espécies: C. obsoletus, C. scoticus, C. dewulfi, C. chiopterus, C. pulicaris, C. punctatus, C. festivipennis; a espécie mais abundante foi C. scoticus. Foi também observado, no decorrer deste estudo, um intervalo de temperaturas de atividade para a espécie C. dewulfi (8 ºC – 18 ºC) e para a espécie C. chiopterus (8 ºC – 20 ºC) diferente dos intervalos reportados na bibliografia. Encontrou-se uma proporção de DAPC de 37,1% (n=13), sendo este um problema reconhecido pela maioria das pessoas questionadas durante este estudo. Conclui-se que o uso de repelentes e proteções mecânicas não é totalmente eficiente para evitar o contacto com os insetos e que a afeção não é sazonal na Alemanha, levando à perda de performance desportiva nos equinos. As despesas dos tutores com a doença relacionaram-se com as medidas profiláticas tomadas e com o alívio básico dos sinais clínicos, variando este custo entre os 20 € e os 250 €/animal/ano. Apesar de nenhum dos tutores questionados ter recorrido a tratamentos mais dispendiosos, como a imunoterapia, as despesas diferem consoante a abordagem tida pelos mesmos, podendo vir a ser ainda mais elevadas.
ABSTRACT - Epidemiological study of Culicoides species captured near horses in north-west Germany - The horse is a very important animal in German culture and economy, since horses can be used for multiple purposes in this country, as well as business opportunities related to the equestrian sector. The different pathologies that can affect these animals have a direct impact on their owners, mainly at the economical level. Among several diseases that can affect equines, one can mention the biting midges’ allergic dermatitis (BMAD) or insect bite hypersensitivity (IBH), caused by insects of the genus Culicoides. The objectives of this study were to understand which Culicoides species were present near equines in northwestern Germany and what is the relative prevalence of IBH in the same area. The insects were captured at seven different sites in the state of Nordrhein Westfalen, Germany, using miniature CDC light traps, in a total of 30 captures. All biotic and abiotic factors observed during the capture periods, which took place between September 26th and December 15th 2019, were registered. Informational flyers and questionnaires were also distributed to the guardians of the horses to assess the relative prevalence of IBH in this area, its seasonality and how the affected animals were kept, as well as to understand the impact of this disease on the equine performance and its economic impact on guardians. A total of 195 insects were caught near equines, and the following species were identified: C. obsoletus, C. scoticus, C. dewulfi, C. chiopterus, C. pulicaris, C. punctatus, C. festivipennis; the most abundant species was C. scoticus. The temperature range of activity found during this study for C. dewulfi (8 ºC - 18 ºC) and for C. chiopterus (8 ºC - 20 ºC) was different from the ranges reported in the bibliography. A proportion of BMAD of 37.1% (n=13) was found, being the problem recognised by the majority of people questioned during this study. It was concluded that the use of repellents and mechanical protections is not fully efficient to avoid contact with insects and the disease is not seasonal in Germany, leading to loss of horse’s sport performance. Guardians expenses with the disease focused on prophylactic means and basic clinical signs relief methods and ranged from €20 to €250. Although none of the guardians questioned had resort to more expensive treatments such as immunotherapy, the costs differ according to the approach taken by them and may be even higher than the ones mentioned.
N/A
Szuber, Maria. "Hornswogglers, whangdoodles and other dirty beasts : the comic grotesque in Roald Dahl's writings for children." Thesis, McGill University, 1999. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=30223.
Full textVan, Renen Charles Gerard. "A critical review of some of Roald Dahl's books for children, with particular reference to a 'subversive' element in his writing, some responses to his work and its place in the education of the child." Thesis, Rhodes University, 1986. http://hdl.handle.net/10962/d1003367.
Full textTong, Amy. "Caenorhabditis Elegans DAPK-1 functions in epidermal damage responses /." Diss., Digital Dissertations Database. Restricted to UC campuses, 2008. http://uclibs.org/PID/11984.
Full textSwei, Allen. "Mechanisms of oxidative stress in the Dahl hypertensive rat /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1997. http://wwwlib.umi.com/cr/ucsd/fullcit?p9820855.
Full textQuezada, Sepúlveda Álvaro. "La teoría pluralista de Robert Dahl: un análisis filosófico." Tesis, Universidad de Chile, 1996. http://repositorio.uchile.cl/handle/2250/134953.
Full textLa primera pregunta que resulta forzoso hacer reza: ¿es necesaria una filosofía política en la actualidad? Y ello porque, más allá del actual descrédito de la política y los políticos, tal actividad se nos muestra, con su trivialidad y su espacio de opinión e ignorancia, como lo más alejado de la venerada y vetusta filosofía. La pregunta no es ociosa, de hecho la política tiene un lugar en la filosofía; tanto desde el punto de vista histórico como sistemático, hay una filosofía que se ocupa de lo político. En seguida, también, ¿necesita lo político (o la política) de una filosofía?, ¿necesitan los políticos de los filósofos? ¿Pueden existir y sobrevivir los sistemas políticos, las políticas y los políticos sin una filosofía? Este conjunto de cuestiones quiero implicar cuando pregunto si es necesaria una reflexión política en nuestra época actual.
Huenemann, Jeannine. "Going Solo with Roald Dahl: Life Rewritten Through Memory." DigitalCommons@USU, 2011. https://digitalcommons.usu.edu/etd/1003.
Full textGünther, Susanne. "Population structure and dynamics of polyphosphate accumulating organisms in a communal wastewater treatment plant." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-89984.
Full textKupčinskaitė, Rita, and Rita Kupčinskaitė-Noreikienė. "Genų, susijusių su apoptoze ir dnr pažaidų atitaisymu, metilinimo ypatumai skrandžio onkogenezės pakopiniame procese." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2013. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130919_143632-54949.
Full textDNA repair and apoptosis are two main pathways supporting the integrity of human genome. After the disturbance of these processes the cell survives, despite the accumulation of DNA lesions, and in this way a basis for a subsequent transformation is formed. In our research we evaluated the epigenetic regulation - methylation - aspects of genes participating in DNA repair function (hMLH1 and MGMT) and also of apoptosis-related genes (DAPK-1, CASP8) in relation to a stepwise gastric oncogenesis process. During this investigation a different hMLH1 gene methylation observation frequency in tissues obtained from separate anatomical parts of the stomach in atrophic pangastritis patients was determined for the first time. It was estimated, that hMLH1 gene methylation in tumor-surrounding non-cancerous tissue in gastric cancer patients could be associated with patient age. Results of survival analysis indicated that MGMT gene methylation is an indicator of better prognosis in case of diffuse form of gastric cancer. During the study we determined some additional associations (not described in previous publications) between methylation combinations of analyzed genes and clinical, morphological and prognostic features of oncological illness.
Pereira, Antonio Kevan BrandÃo. "Teoria DemocrÃtica ContemporÃnea: o conceito de poliarquia na obra de Robert Dahl." Universidade Federal do CearÃ, 2013. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=12225.
Full textEste trabalho analisa o conceito de poliarquia na obra de Robert Dahl. O autor faz uma distinÃÃo entre âdemocracia idealâ e âdemocracia realâ. Para ele, a palavra âdemocraciaâ evoca o cenÃrio grego original de participaÃÃo direta, nÃo sendo mais adequada para classificar os regimes representativos contemporÃneos. Tais regimes sÃo pobres aproximaÃÃes dos ideais democrÃticos, e que por isso devem ser classificados como âpoliarquiasâ. Por meio de uma pesquisa bibliogrÃfica, o trabalho objetiva evidenciar e analisar, mais especificamente, a investigaÃÃo que o autor realizou no seu clÃssico livro âPoliarquia: ParticipaÃÃo e OposiÃÃoâ, no qual ele abordou o tema da transiÃÃo de regimes, procurando compreender quais as condiÃÃes que favorecem ou impedem a transiÃÃo de um regime nÃo poliÃrquico para um regime poliÃrquico.
This paper analyzes the concept of polyarchy in the work of Robert Dahl. The author makes a distinction between "ideal democracy" and "real democracy". For him, the word "democracy" evokes the original Greek scenario of direct participation, no longer appropriate to classify regimes representative contemporaries. Such schemes are poor approximations of democratic ideals, and therefore should be classified as "polyarchies". Through a literature search, this work aims at identifying and analyzing more specifically, the research that the author conducted in his classic book "Polyarchy: Participation and Opposition," in which he addressed the issue of regime transition, trying to understand what conditions that favor or hinder the transition from a regime not polyarchical to a polyachical regime.
Moruzzi, Lara. "Dal formalismo Hamiltoniano alla meccanica statistica." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/18212/.
Full textPiani, Goffredo. "Sull'interferenza quantistica indotta dal potenziale gravitazionale." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/19167/.
Full textAssenza, Concetta. "La canzonetta dal 1570 al 1615 /." Lucca : Libreria musicale italiana, 1997. http://catalogue.bnf.fr/ark:/12148/cb36999066q.
Full textGioventu, Alessandra. "Neutrini dal piano galattico con ANTARES." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amslaurea.unibo.it/9586/.
Full textVeres, Michael J. "The Saguwentje of Berg En Dal." Kent State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=kent1353550765.
Full textDrago, Gene K. "Studies Directed to the Optimization of Fermentation of Rhodococcus sp. DAP 96253 and Rhodococcus rhodochrous DAP 96622." Digital Archive @ GSU, 2007. http://digitalarchive.gsu.edu/biology_diss/24.
Full textRomera, Lavínia Maria Dal\'Mas. "Caracterização da inter-relação entre as vias de sinalização Notch e TLR na paracoccidioidomicose experimental." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/9/9142/tde-22122016-113633/.
Full textParacoccidioidomycosis is a systemic mycosis of deep nature that primarily affects the lung and can spread via lymphatic and hematogenous to other organs and tissues. It is mainly caused by Paracoccidioides brasiliensis fungus which exhibit thermal dimorphism. The innate immune system mediated by macrophages is extremely important for the control of infection and is involved in the induction and regulation of immune/inflammatory response. These cells are able to recognize pathogens through pattern recognition receptors (PRRs) such as Toll-like receptors (TLR). Beyond these PRRs, the importance of Notch signaling has recently been demonstrated in the innate immune system and the regulation of macrophage activity. Our data demonstrate that the Pb18 strain of P. brasiliensis is able to activate the Notch1 receptor in J774 macrophages. Activation of this receptor with also activation of TLR 4 (via LPS) induces IL-6 production, induces phagocytosis and decreases fungal burden, which favors the pathogenesis. By using a γ-secretase pharmacological inhibitor (DAPT) for inhibiting the activation of Notch1 receptor on macrophages, it is possible to observe decreased fungal burden, less production of IL-6, and increased TNF-α and phagocytosis. However, due to the absence of TLR 4 receptor in bone marrow derived macrophages from TLR 4-/- mice, these macrophages showed decreased phagocytic ability and also reduced fungal burden in the presence of DAPT, showing a relationship between TLR 4 and Notch1. In addition, we made a treatment with DAPT in BALB/c mice prior to infection with Pb18. And our results showed that DAPT-treated animals exhibited a decrease of fungal burden in the lungs, and a decrease of IL-6. Furthermore, we observed an increase of IgG after 45 days of infection, indicating probably a healing of these animals. Same treatment was made in BALB/c NUDE mice, followed by infection with Pb18. In these animals, we observed an increased production of proinflammatory cytokines in the lung and increased CD19+ cells, but fungal burden was similar in both group (treated and untreated), which indicates that treatment with DAPT is dependent on T cell response. Taken together, these results showed that Pb18 is able to activate the Notch 1 receptor on macrophages and uses the Notch-TLR 4 signaling pathway as a possible escape mechanism, and may provide a new immunity study approach in experimental paracoccidioidomycosis.
de, Assis Oliveira Coutinho Junior Francisco. "Teoria política e participação democrática : Dahl e a democracia em diferentes escalas." Universidade Federal de Pernambuco, 2011. https://repositorio.ufpe.br/handle/123456789/1871.
Full textConselho Nacional de Desenvolvimento Científico e Tecnológico
A democracia é, atualmente, um dos temas mais recorrentes no âmbito da Ciência Política. Autores diversos têm contribuído, ao longo de décadas, na elucidação de múltiplos problemas relacionados àquela forma de governo, tendo destaque os trabalhos do teórico norte americano Robert Dahl, que tem se destacado, dentre outros motivos, pelo enfoque apresentado sobre o tema da relação entre democracia e escala. Sobre a questão da democracia, do ponto de vista analítico, não se pode perder de vista a sua relação histórica com a problemática das unidades políticas, ou seja, a ligação entre regime democrático e tamanho espacial, o que inclui a dimensão geográfica e populacional do sistema. Para Dahl, em muitas de suas obras, a construção da democracia encontra-se estreitamente relacionada ao ambiente em que ela se propõe ser aplicada. Assim, define esse autor, sempre tendo em mente a questão do espaço, a existência de vários modelos de democracia, apropriados para cada escala - desde a pequena à grande unidade. Assim sendo, é nosso objetivo analisar, na presente dissertação, a reflexão de Dahl sobre a questão da relação entre democracia e escala. Deste modo, visamos também compreender os tipos de regimes democráticos desenvolvidos por este cientista político e a relação destes regimes com o tamanho das unidades políticas em que eles são consagrados
da, Silva Calixto Merilane. "Análise citogénetica comparativa entre Glossophaga soricina, Platyrrhinus lineatus e Sturnira lilium (Phyllostomidae, Chiroptera)." Universidade Federal de Pernambuco, 2008. https://repositorio.ufpe.br/handle/123456789/6236.
Full textCromossomos mitóticos de Glossophaga soricina (2n=32,XY; NF=60), Platyrrhinus lineatus e Sturnira lilium (2n=30,XY; NF=56) foram analisados através da coloração convencional, bandeamento C, impregnação com nitrato de prata (AgNO3) e fluorocromos base-específicos. Dados da análise convencional obtidos para as três espécies estão de acordo com aqueles descritos na literatura, exceto pela morfologia do cromossomo Y de P. lineatus, indicando variação cromossômica geográfica para a espécie. Os blocos de HC na região distal do braço curto dos pares 5, 6, 7 e cromossomo X, observados pelo bandeamento C, em P. lineatus e S. lilium, além da coloração diferencial do braço longo do cromossomo X de Sturnira lilium correspondem a um padrão compartilhado por alguns representantes de Stenodermatinae. A fraca marcação CMA3+ nas regiões heterocromáticas pericentroméricas e distais de alguns cromossomos indica uma predominante associação de heterocromatina com seqüências ricas em pares de bases GC. Contudo, os padrões diferenciais obtidos com o emprego de fluorocromos base-específicos confirmaram a heterogeneidade da HC quanto à sua composição (rica em AT e/ou GC) e comprovaram características diferenciais das seqüências intergênicas associadas às RONs (CMA3 positiva, negativa ou sem especificidade) em representantes de Phyllostomidae
Paula, de Moraes Ana. "Utilização de marcadores cito-moleculares na identificação de cromossomos mitóticos em Citrus e Poncirus." Universidade Federal de Pernambuco, 2007. https://repositorio.ufpe.br/handle/123456789/667.
Full textConselho Nacional de Desenvolvimento Científico e Tecnológico
A definição das espécies dentro dos gêneros pode ser problemática e as espécies de Citrus configuram um exemplo clássico de classificação conflitante. O presente estudo visou auxiliar na compreensão da sistemática deste grupo, ampliando a análise citogenética dos gêneros Citrus e Poncirus. Inicialmente foi analisada a variabilidade cariotípica dos pomelos (toranja × laranjadoce), indicando diferentes cariótipos entre as cultivares. Provavelmente, os diferentes cariótipos são resultantes de eventos de hibridação independentes, envolvendo diversos acessos de toranja. No entanto, as toranjas analisadas mostraram cariótipos idênticos e homozigotos, corroborando sua classificação como espécie pura. O segundo estudo dedicou-se à análise de 13 acessos de tangerinas. Em todos os acessos, o cromossomo D/5S-45S foi observado em homozigose e considerado um bom marcador para este grupo. A tangerina é classificada com uma das espécies puras, porém os dados obtidos sugerem que compreendam três espécies básicas: C. sunki, C. reshni e C. deliciosa, todas com cariótipos homomórficos, sendo que as duas primeiras foram idênticas. O terceiro trabalho visou refinar a análise cromossômica a partir da FISH de seqüências de cópia única. A espécie utilizada foi P. trifoliata, importante fonte de genes de resistência para Citrus. A análise da hibridização foi realizada comparativamente ao padrão de bandeamento CMA/DAPI e localização de sítio de DNAr 45S, permitindo reconhecer os nove pares cromossômicos, além de mapear a região de resistência ao VTC
Franklin, Donald R. J. "DAPM, a dynamic associative priming model of immediate free recall." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ63305.pdf.
Full textDahl, David [Verfasser]. "Electromagnetic Modeling and Optimization of Through Silicon Vias / David Dahl." Aachen : Shaker, 2018. http://d-nb.info/1162794062/34.
Full textRuggiu, Matteo. "The function of DAZL and RBM, two candidate fertility genes." Thesis, Open University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300014.
Full textCarletti, Cecilia. "Turning Progettazione di un brick asettico dall' idea allo scaffale." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2016.
Find full textGrenier, Alain Guy. "La valeur prédictive du modèle polyarchique de Robert A Dahl." Thesis, University of Ottawa (Canada), 1988. http://hdl.handle.net/10393/22122.
Full textSousa, Martins Joao Pedro. "Functional analysis of DAZL-mediated translation activation during mammalian gametogenesis." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/9893.
Full textNilsson, Caroline. "Bortom historiens slut : En jämförande undersökning av nio U-länders demokratiska utveckling." Thesis, Växjö University, School of Social Sciences, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:vxu:diva-1432.
Full textBortom historien slut – Beyond the end of history
According to Robert Dahl there are seven criteria that have to be fulfilled in order for a state to be democratic. Dahl also states that there are several factors that effect the development of democracy. In today’s world it is mostly developing countries that have failed to bring about democratic changes. It is the developing country that is in focus in this thesis.
The purpose is to examine if there are any particularly advantageous factors that can bring about or promote the development of democratic institutions.
The questions are:
What factor has effected the development of democratic institutions?
Which, if any, of Dahl’s seven criteria is found within each state today?; do they correctly reflect the democratic situation?
Can any connection between the states democratic development be found in a comparison?
In a comparison between nine countries the different factors have been examined. The result shows that pluralism is a key factor for development of democracy in a developing country. External influence is on the other hand not important.
Keywords: developing countries, democratization, Robert Dahl
Nyckerlord: utvecklingsländer, demokratisering
Rowton, Sharon. "Pathological role of double-stranded DNA antibodies in multiple sclerosis." Thesis, University of Bradford, 2009. http://hdl.handle.net/10454/4293.
Full textColonnese, Benni Vittoria. "Dante nel cinema dal muto al digitale." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0021/NQ45726.pdf.
Full textGenerali, Daniela. "Dal baratto alla moneta: un approccio simulativo." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amslaurea.unibo.it/3177/.
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