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Dew, Robert, and mikewood@deakin edu au. "The development of DAL and DAPL languages for building distributed applications." Deakin University. School of Information Technology, 2002. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20050826.101627.
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A common characteristic among parallel/distributed programming languages is that the one language is used to specify not only the overall organisation of the distributed application, but also the functionality of the application. That is, the connectivity and functionality of processes are specified within a single program.
Connectivity and functionality are independent aspects of a distributed application. This thesis shows that these two aspects can be specified separately, therefore allowing application designers to freely concentrate on either aspect in a modular fashion. Two new programming languages have been developed for specifying each aspect. These languages are for loosely coupled distributed applications based on message passing, and have been designed to simplify distributed programming by completely removing all low level interprocess communication. A suite of languages and tools has been designed and developed. It includes the two new languages, parsers, a compilation system to generate intermediate C code that is compiled to binary object modules, a run-time system to create, manage and terminate several distributed applications, and a shell to communicate with the run-tune system. DAL (Distributed Application Language) and DAPL (Distributed Application Process Language) are the new programming languages for the specification and development of process oriented, asynchronous message passing, distributed applications. These two languages have been designed and developed as part of this doctorate in order to specify such distributed applications that execute on a cluster of computers. Both languages are used to specify orthogonal components of an application, on the one hand the organisation of processes that constitute an application, and on the other the interface and functionality of each process. Consequently, these components can be created in a modular fashion, individually and concurrently.
The DAL language is used to specify not only the connectivity of all processes within an application, but also a cluster of computers for which the application executes. Furthermore, sub-clusters can be specified for individual processes of an application to constrain a process to a particular group of computers. The second language, DAPL, is used to specify the interface, functionality and data structures of application processes. In addition to these languages, a DAL parser, a DAPL parser, and a compilation system have been designed and developed (in this project). This compilation system takes DAL and DAPL programs to generate object modules based on machine code, one module for each application process. These object modules are used by the Distributed Application System (DAS) to instantiate and manage distributed applications.
The DAS system is another new component of this project. The purpose of the DAS system is to create, manage, and terminate many distributed applications of similar and different configurations. The creation procedure incorporates the automatic allocation of processes to remote machines. Application management includes several operations such as deletion, addition, replacement, and movement of processes, and also detection and reaction to faults such as a processor crash. A DAS operator communicates with the DAS system via a textual shell called DASH (Distributed Application SHell). This suite of languages and tools allowed distributed applications of varying connectivity and functionality to be specified quickly and simply at a high level of abstraction. DAL and DAPL programs of several processes may require a few dozen lines to specify as compared to several hundred lines of equivalent C code that is generated by the compilation system. Furthermore, the DAL and DAPL compilation system is successful at generating binary object modules, and the DAS system succeeds in instantiating and managing several distributed applications on a cluster.
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Gaston, Emilia. "Framing a Sacred Fight: Framing Analysis and Collective Identity of the #noDAPL Movement." Thesis, University of North Texas, 2020. https://digital.library.unt.edu/ark:/67531/metadc1703426/.
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The #noDAPL movement was an Indigenous-led environmental social movement occurring between 2015 and 2017, in which the Standing Rock Sioux and other American Indian tribes comprising the Oceti Sakowin garnered support to oppose the 1,172-mile Dakota Access Pipeline. Pipeline opponents agreed that the pipeline's construction posed a threat to the health and safety of tribal members and other residents of the area and that the pipeline's path crossed previously-designated tribal treaty boundaries, compromising tribal sovereignty. In this body of work, I utilize Facebook data from the Sacred Stone Camp Facebook page to locate and identify collective action frames and core framing tasks, adhering to social movement framing theory. Further, I provide insight into the movement's most used collective action frames and how their use enabled to movement to maintain occupation at protest camps along the Missouri River, garner resources from participants and gain international social support. I also draw on concepts of pan-Indianism and supratribalism to discuss indigenous collective identity, as well as concepts like relational values and Indigenous traditional knowledge to better assess the nuances of Indigenous environmental activism and how this movement evoked discussions of modern day settler colonialism.
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Chou, Danielle 1981. "Dahl friction modeling." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/32826.
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Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2004.Includes bibliographical references (p. 22).
The drive behind improved friction models has been better prediction and control of dynamic systems. The earliest model was of classical Coulomb friction; however, the discontinuity during force reversal of the Coulomb friction model has long been a point of contention since such a discontinuity does not accurately portray the behavior of real systems. Other models have been suggested, but variations of the Dahl solid friction model remain some of the simplest yet most useful. Dahl's original theory proposed that friction behaved as a stress acting upon the quantum mechanical bonds at the interface. Thus, the relationship between frictional force and position would be analogous to a stress-strain curve, complete with hysteresis should there be permanent displacement akin to plastic deformation in materials. This project reviews the variations of Dahl friction models popular in the literature and then demonstrates it both analytically via Matlab and Simulink simulations and experimentally by observing the behavior of a limited angle torque motor.
by Danielle Chou.
S.B.
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Lin, Yao. "Control of DAPK-1 degradation." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4189.
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DAPK-1 is calcium-calmodulin regulated protein kinase involved in multiple cellular pathways including apoptosis, autophagy, cell survival and motility. The cytokine TNF-α has been reported to induce the degradation of DAPK-1. Here I identified the protease cathepsin B as a novel binding partner of DAPK-1 that protects DAPK-1 from TNF-α induced degradation. Using deletion mutants of DAPK-1, I mapped the cathepsin B binding domain on DAPK-1 to amino acids 836-947. Overexpression of this mini-protein DAPK-1(836-947) facilitated degradation of full-length DAPK-1 and apoptosis induced by TNFR-1. Moreover, siRNA mediated knock-down of DAPK-1 enhanced TNF-α induced apoptosis, confirming the role of DAPK-1 as a survival factor in the TNF-α signalling pathway. In addition, a splice variant of DAPK-1, which I have called s-DAPK-1, was discovered. s-DAPK-1 shares part of DAPK-1’s ankyrin repeats region and cytoskeletal binding domain, and possesses an unique tail region, which contains a cleavage site at its first two amino acids. Unlike DAPK-1, s-DAPK-1 does not contribute to apoptosis induced by high level of MEK/ERK signalling, but it does mimic DAPK-1’s function to induce membrane blebbing. The proteolytically processed form of s-DAPK-1 is more active in the induction of membrane blebbing, which may be due to its higher stability compared to that of full-length s-DAPK-1, suggesting that the tail region can control s-DAPK-1 stability and activity. Co-transfection of s-DAPK-1 and DAPK-1 leads to reduction in DAPK-1 expression level, suggesting a role for s-DAPK-1 to regulate DAPK-1 stability. The kinase domain of DAPK-1 is the region required for s-DAPK-1 to promote DAPK-1 degradation. Surprisingly, s-DAPK-1 does not bind directly to DAPK-1, suggesting that the interaction is indirect and mediated by as yet unidentified accessory proteins. Finally, the experiments with proteasome and lysosome inhibitors indicated that s-DAPK-1 induces DAPK-1 degradation via both lysosome and proteasome pathways.
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Terwilliger, Miranda Lilian Naeser. "Population and habitat analyses for Dall's sheep (Ovis dalli) in Wrangell-St. Elias National Park and Preserve." PURL, 2005. http://www.arlis.org/docs/vol1/71013833.pdf.
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Flynn, Patrick G. "Activation of Non-Muscle Myosin IIB Helps Mediate TNF-Alpha Cell Death Signaling." Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_dissertations/369.
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TNF-alpha can stimulate a variety of kinases with the ability to activate non-muscle myosin II. As a result, increases in actin filament formation and actomyosin contractility (AMC) have been reported in response to TNF-alpha. These events are thought to play an important role in mediating TNF-alpha induced apoptosis but how they do so is unclear. In this study we prevented non-muscle myosin II activation in response to TNF-alpha by treating cells with the myosin light chain kinase (MLCK) inhibitor ML-7 or through isoform specific siRNA knockdown of myosin IIA and IIB. We found that treatment with ML-7 or knockdown of myosin IIB, but not IIA, impaired the cleavage of caspase 3 and caspase 8 as well as nuclear condensation in response to TNF-alpha. During this cell death process myosin II seemed to function independent of AMC since treatment of cells with blebbistatin or cytochalasin D failed to inhibit TNF-alpha induced caspase cleavage. Immunoprecipitation studies revealed associations of myosin IIB with clathrin and FADD in response to TNF-alpha suggesting a role for myosin IIB in TNFR1 endocytosis and DISC formation. Taken together these findings suggest that myosin IIB activation promotes TNF-alpha cell death signaling in a manner independent of its force generating property.
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Punzet, Robert. "99mTc-HYNIC-DAPI-DNA-Bindungsnachweis und Nachweis von DNA-Doppelstrangbrüchen durch 99mTc-HYNIC-DAPI mittels Agarose-Gelelektrophorese." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-146456.
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Hintergrund: Ein sehr häufig in der nuklearmedizinischen Diagnostik genutztes Radionuklid ist 99mTc. Es emittiert Gammastrahlung mit einer relativ niedrigen Energie (140 keV) und hat eine kurze Halbwertszeit von 6 h. Zusätzlich zur Gammastrahlung entstehen bei jedem Zerfall von 99mTc Auger-Elektronen. Diese niederenergetischen Elektronen, sehr kurzer Reichweite verfügen über einen hohen LET und erzeugen somit eine ausreichende Energiedeposition, um direkte DSB zu erzeugen. Bei Untersuchungen zu Chemotoxizität und Radiotoxizität mit Zellexperimenten gilt es eine Vielzahl an verschiedenen Schutzmechanismen, Reparaturmechanismen und Signalkaskaden in Zellen zu beachten, welche häufig noch nicht vollständig erforscht sind. Um das schädigende Potential von unterschiedlichen Substanzen und Strahlenqualitäten auf die DNA zu untersuchen, wurde ein zellfreies System gewählt. Ziel dieser Arbeit war es, neben den Strahlenqualitäten der Alpha-, Beta, Gamma- und Röntgenstrahlung die Auger-Elektronen des 99mTc auf ihr Potential zur Induktion von DNA-Strangbrüchen zu untersuchen. Hierfür stand die Substanz 99mTc-HYNIC-DAPI zur Verfügung, welche 99mTc an das Plasmid binden und somit in direkte DNA-Nähe bringen kann. Material und Methode: Alle Versuche wurden mit dem Plasmid pUC 19, einem künstlich hergestellten, bakteriellen Plasmid mit 2686 Basenpaaren, welches als nackte DNA ohne Proteine vorliegt, durchgeführt. Der Vergleich zwischen bestrahltem Plasmid in Ab- und Anwesenheit des Radikalfängers DMSO gibt Hinweise darauf, ob Strangbrüche direkt induziert oder nach Radikalbildung indirekt erzeugt werden. Bei radikalvermittelter Wirkung verhindert DMSO DNA-Strangbrüche und die ungeschädigte Supercoiled-Plasmid-Konformation bleibt erhalten. Nach Bestrahlung des Plasmids erfolgte der Nachweis von Strangbrüchen mittels Agarose-Gelelektrophorese. Bekommt ein Plasmid Einzel- oder Doppelstrangbrüche, so verändert sich seine Konformation zu einem ringförmigen/open circle (ESB) oder einem linearen Plasmid (DSB). Durch veränderte Laufeigenschaften im Agarosegel sind die verschiedenen Konformationen voneinander trennbar. Nach Anfärben der DNA mit dem Fluoreszenzfarbstoff Ethidiumbromid konnte das fluoreszierende Plasmid fotografiert und die Intensität der Konformationsbanden quantifiziert werden. Ergebnisse: Zuerst wurde die Reproduzierbarkeit der Methodik überprüft und festgestellt, dass eine Korrelation zwischen Plasmidmasse und Fluoreszenzintensität besteht. Anschließend wurde in Vorversuchen gezeigt, dass die Inkubationstemperaturen, pH-Werte und der Radikalfänger DMSO keinen Einfluss auf die Plasmidintegrität haben. Bei Bestrahlung mit Röntgenstrahlung, dem Beta-Strahler 188Re und dem nicht DNA-gebundenen Gamma-Strahler und Auger-Emitter 99mTc konnte mit steigender Dosis eine Zunahme an ESB festgestellt werden. Vergleichsproben mit DMSO zeigten keinen Anstieg von ESB, was auf eine radikalvermittelte 67 DNA-Schädigung mittels Reaktiver Sauerstoffspezies (ROS) hinweist. Ab einer Energiedosis von ca. 80 Gy konnten nach Bestrahlung mit 188Re und 99mTc zusätzlich zu den ESB auch DSB nachgewiesen werden. DMSO konnte in den Vergleichsproben sowohl die ESB als auch die DSB erfolgreich verhindern. Bei einer sehr hohen Dosis ≥ 600 Gy zeigte DMSO Kapazitätsgrenzen und es konnten nicht mehr alle Strangbrüche verhindert werden. Die Bestrahlung mit dem Alpha-Strahler (hoher LET) 223Ra fügte, im Vergleich zu Strahlung mit niedrigem LET, dem Plasmid überproportional viele DSB zu. Einige dieser DSB konnten nicht durch DMSO verhindert werden, was auf einen direkten DNA-Schaden bzw. eine zu hohe Radikaldichte hinweist. Ein noch stärkerer direkter Effekt konnte beobachtet werden, wenn 99mTc über die Substanz 99mTc-HYNIC-DAPI an DNA gebunden wurde. Dabei konnten schon ab einer Energiedosis von 4 Gy DSB erzeugt werden, welche trotz Radikalfänger nicht verhindert werden konnten. Schlussfolgerung: Dieser bei 99mTc-HYNIC-DAPI beobachtete Effekt wird den Auger-Elektronen zugeschrieben. Aufgrund ihrer kurzen Reichweite und ihres hohen LET sind sie in der Lage direkte DSB zu erzeugen, wenn sie DNA-gebunden sind oder sich in geringem Abstand zur DNA befinden. Die Ergebnisse der Experimente weisen auf ein therapeutisches Potential von 99mTc hin. Weitere Untersuchungen müssen zeigen, ob eine Adressierung von 99mTc an die DNA im Zellkern einer intakten Zelle zu verwirklichen ist und ob DNA-gebundenes 99mTc durch die Energie der Auger-Elektronen den Zelltod herbeiführen kann. Im nächsten Schritt sollte die Erforschung von Trägersubstanzen erfolgen, welche es ermöglichen Auger-Emitter spezifisch an die DNA von Tumorzellen zu koppelnIntroduction and aim of the study: A radionuclide commonly used in diagnostic nuclear medicine is 99mTc. It emits gamma rays with a relatively low energy (140 keV) and has a short half-time (6h). In addition to gamma rays, 99mTc radiates so called Auger-electrons with low energy, low range and high linear energy transfer. Due to the high-LET Auger-electrons have a sufficient energy deposition to induce direct double-strand breaks to the DNA. In these experiments we used plasmid DNA to evaluate damage induced to biological systems by different chemotoxical substances and radionuclides as well as external radiation. By using plasmids instead of cell cultures we avoid lots of unexplored signal pathways in cells and it is possible to quantify chemotoxical and radiation damage to the DNA. Materials and methods: The double-stranded plasmid pUC 19 with 2686 bp is used in all experiments. It is a synthetically produced bacterial plasmid without any proteins. To distinguish between directly and indirectly (radical induced) induced damage we used the radical scavenger DMSO. Indirectly induced damage via reactive oxygen species (ROS) can be prevented by DMSO. The quantification of supercoiled forms, single strand breaks (SSB) and double strand breaks (DSB) was measured by the method of agarose gel electrophoresis. After the electrophoresis, agarose gels are dyed in ethidium bromide and imaged with a ccd-camera using ultraviolet transillumination. The bands of the different plasmid forms were quantified through the FIJI computer program. Results: First of all a correlation between plasmid mass and fluorescence intensity was shown. In a pretrial no damaging effect to the plasmid from incubation temperature, pH-value and radical scavenger DMSO appeared. Afterwards we examined chemotoxical SnCl2, external x-rays, the alpha emitter 223Ra, the beta emitter 188Re, gamma- and Auger-emitter 99mTc and the DNA-bound 99mTc-HYNIC-DAPI. The radical scavenger DMSO was used to differentiate between indirect (radical induced) and direct DNA-damage. All different radiation qualities showed an increasing DNA-damage with increasing energy dose. For the low-LET radiation qualities like chemotoxical SnCl2, external x-rays, the beta emitter 188Re and not DNA-bound 99mTc, DMSO showed the quality to prevent the damage. After the deposition of an energy dose ≥ 600 Gy DMSO showed a limitation in his scavenger capacity. During radiation with high-LET beams like 223Ra or DNA-bound 99mTc-HYNIC-DAPI DMSO showed less or nearly no ability to prevent DNA-damage. A 4 Gy dose of 99mTc-HYNIC-DAPI was able to induce DSB into the plasmid. These DSB could not be prevented by DMSO. The lower ESB:DSB ratio for high-LET beams also displays that direct damage is more likely to create DSB than indirect damage. Conclusion: In conclusion we can say that DNA-bound 99mTc-HYNIC-DAPI was most appropriate to induce DSB via a direct effect. It was impossible to prevent this damage due to adding the 69 radical scavenger DMSO. We attribute this to low range, low-LET Auger-electrons and suppose that it may be possible to use DNA-bound 99mTc for therapeutic purpose. Further research has to show if 99mTc can be targeted to the DNA of intact cells and if suitable tracers can be found to safely target and kill tumor cells
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Smith, Joel W. S. "Investigating the mechanism of translational stimulation by Deleted in Azoospermia-like." Thesis, University of Edinburgh, 2008. http://hdl.handle.net/1842/4849.
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The proper expression of a gene to a protein is a complicated process with many steps. One of the major steps is translation, the process of decoding a messenger RNA signal and the building of a protein from its component parts. The control of translation is one of the major steps for the overall control of gene expression and its dysregulation is associated with a wide variety of human diseases including neurological, metabolic and reproductive disorders. Dazl family proteins are germ cell restricted RNA binding proteins that contain a motif characteristic of this family, the DAZ domain. Whilst humans encode all three family members DAZ, DAZL and BOULE, flies only possess the boule gene. The members of this family have an essential conserved role in gametogenesis in a wide variety of organisms from worm to man with loss of function resulting in phenotypes ranging from male or female infertility or both. However, little is known about the molecular role of these proteins in germ cell development. A previous study within the laboratory showed that several vertebrate Dazl family members can stimulate translation of a reporter gene in Xenopus laevis oocytes, suggesting a conserved role in mRNA specific translational control. This is consistent with studies in invertebrates. It was proposed that Dazl proteins fulfil this function through an interaction with a translation initiation factor, poly(A) binding protein, PABP. The aim of this thesis was to further refine this model of action. The work presented here investigates several fundamental questions regarding the mechanism of Dazl-mediated stimulation. First, it investigated the step of translation initiation that Dazl acts upon and explored the initiation factors that may be required. Second, it addressed in more detail the requirements for an interaction between Dazl and the poly(A) binding protein, PABP. Third, it examined the potential role of another factor, DAZ associated protein 1, DAZAP1, in Dazl-mediated stimulation. The role of multi-protein complexes containing Dazl bound to the 3’UTR that localise, repress and stimulate translation of specific mRNAs at defined times during gametogenesis are discussed.
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Carnino, Cecilia. "Dal lusso al consumo." Paris 1, 2012. http://www.theses.fr/2012PA010602.
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La thèse présente a pour objet de reconstruire les implications intellectuelles de la réflexion sur le luxe et sur la consommation qui fut effectuée dans l'Italie de la seconde moitié du dix-huitième siècle, et ce notamment durant le passage de l'ancien régime à la période révolutionnaire. Il s'agit ici de mettre en évidence l'importance que cette réflexion assuma en Italie durant la seconde moitié du dix-huitième siècle, tant du point de vue économique que politique. Notre recherche met notamment en lumière la forte dimension politique que la réflexion économique sur le luxe et la consommation revêtit à cette époque en Italie. Elle a permis en effet de véhiculer une critique radicale du système hiérarchique de l'ancien régime et de proposer un nouveau modèle de société fondé sur des bases plus égalitaires et capables d'harmoniser intérêts privés, justice sociale et prospérité publique. Ce travail a permis également de voire la culture politique italienne durant le passage de l'ancien régime à la phase révolutionnaire. La réflexion sur le luxe et la consommation permet de comprendre combien les patriotes ont adhéré amplement aux principes du libéralisme économique: ils avaient en effet la conviction que c'était précisément sur ce terrain que l'on pourrait conserver les transformations sociales réalisées grâce à la chute de l'ancien régime. Suivant le sillon de la réflexion économique qui avait caractérisé l'Italie à partir des années 1760, mais en même temps pleinement conscients de la nécessité d'une fracture politique radicale, les patriotes ont misé sur la garantie de l'égalité des opportunités. Ceci constituait à la fois un moyen privilégié pour assurer prospérité publique et amélioration générale du bien-être matériel, ainsi qu'un instrument visant à l'égalité des conditions sociales.
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Edwards, Jennifer Somerville 1967. "Louise Dahl-Wolfe: A fashion photographer redefined." Thesis, The University of Arizona, 1996. http://hdl.handle.net/10150/291450.
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Dahl-Wolfe (1895-1989) is best-known as a fashion photographer, her photographic life encompassed a pattern of art and documentary ideas interwoven over a forty-year period. This thesis describes her early art influences and explores her photography career in regards to the historical and cultural developments from World War I through the 1950s. Dahl-Wolfe is compared with her contemporaries such as Consuelo Kanaga, Dorothea Lange, Edward Weston, Richard Avedon, and Henri Cartier-Bresson. The study reveals how Dahl-Wolfe's work reflects photography's evolution over a specific period and how traditional constructions affect the reception of commercial photographers. Conclusively, Dahl-Wolfe's oeuvre straddles such an array of constructed arenas that she virtually fell through the cracks and has been narrowly defined as a result of art historical definitions.
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Gill, Mark E. "Dazl regulates mouse embryonic germ cell development." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/58372.
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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2010.Cataloged from PDF version of thesis.
Includes bibliographical references.
In the mouse, germ cells can undergo differentiation to become either oocytes or spermatozoa in response to sex of their gonadal environment. The nature of the germ cell-intrinsic aspects of this signaling have not been well studied. The earliest known sex-specific difference in germ cells is the initiation of meiosis in female, but not male, embryonic germ cells. Experiments were performed showing that germ cells of both sexes transit through a state, the meiosis competent germ cell, that is required for initiation of meiosis. Acquisition of this state requires the function of the germ cellspecific RNA binding protein DAZL. The sufficiency for the absence of meiosis to drive male germ cell differentiation was then tested by examining non-meiotic XX germ cells in the Dazl-deficient ovary. These cells did not exhibit male differentiation indicating that the absence of meiosis is not sufficient for male differentiation. XX Dazl-deficient germ cells also failed to exhibit normal female differentiation. In addition, XY Dazl-deficient germ cells do not display characteristics of either male or female germ cells. Taken together, these results indicate that germ cells must first undergo a sex non-specific differentiation step prior to acquiring sexual fate.
by Mark E. Gill.
Ph.D.
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Barros, Leila de Almeida. "Darl, o homem de gênio em Faulkner." Universidade Estadual de Londrina. Centro de Letras e Ciências Humanas. Programa de Pós-Graduação em Letras, 2014. http://www.bibliotecadigital.uel.br/document/?code=vtls000194230.
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Considerada pela crítica uma das mais enigmáticas criações de William Faulkner, a personagem Darl Bundren, de As I Lay Dying (1930), é aqui analisada à luz do pensamento do filósofo alemão Arthur Schopenhauer, principalmente no que diz respeito à noção do homem de gênio, conforme apresentado no terceiro livro de O Mundo como Vontade e como Representação (1819). Em As I Lay Dying, o autor leva ao extremo suas experimentações ficcionais por meio de 59 monólogos de quinze narradores que se revezam para contar a jornada da família Bundren, da qual participam direta ou indiretamente. Em uma carroça, a família de pequenos agricultores transporta o cadáver de sua matriarca até Jefferson, a capital do condado imaginário Yoknapatawpha, a fim de cumprir a promessa de enterrá-la junto ao restante de seus familiares. Mais adiante, nota-se que aquilo que se poderia chamar de uma verdadeira odisseia não é concluída pela maior parte dos Bundrens por honra à memória da mãe, mas sim por suas ambições pessoais. Enquanto os demais Bundrens, em termos schopenhauerianos, permanecem presos ao mundo do conceito e da abstração, Darl parece contemplar nesses mesmos objetos a sua verdade, desprezando uma reflexão superficial sobre a utilidade que teriam no mundo fenomênico. Dessa forma, a personagem seria como o homem de gênio, o puro sujeito que conhece (SCHOPENHAUER, 2005, p. 254), o único que possui uma sensibilidade artística e que se entrega à seu trágico destino porque o mundo à que sua família se confina não é o seu mundo (FAULKNER, 2002, p. 223). A fim de fazer essa aproximação entre o pensamento schopenhaueriano e o herói faulkneriano, esta dissertação se divide em quatro capítulos. O capítulo introdutório discutirá brevemente o movimento modernista americano, seu contexto histórico, os problemas nele tratados, além de sua diversidade de temas. Além disso, discute-se o contexto de produção de Faulkner, com uma extensa revisão bibliográfica sobre as especificidades de sua obra e suas principais preocupações literárias. Uma revisão bibliográfica da fortuna crítica de As I Lay Dying é apresentada no primeiro capítulo. No segundo, apresenta-se um delineamento de O Mundo para que se faça melhor compreender a teoria do homem de gênio. Aqui, buscar-se-á ainda aproximar a filosofia schopenhaueriana à obra de Faulkner, a partir da discussão de trabalhos que lograram unir uma ou outra de suas preocupações estéticas às premissas do filósofo de Frankfurt. Por fim, no terceiro capítulo, será realizada a análise do romance a partir da noção schopenhaueriana do homem de gênio.Considered by critics as one of the most enigmatic creations of William Faulkner, the character Darl Bundren in As I Lay Dying (1930) is here examined in the light of the thought of the German philosopher Arthur Schopenhauer, especially with regard to the notion of the genius as presented in the third book of The World as Will and Representation (1819). In As I Lay Dying, the author takes to the extreme his fictional experimentations through 59 monologues of fifteen narrators who take turns to tell the journey of the Bundren family, in which they participate directly or indirectly. In a wagon, the family of small farmers carries the corpse of their matriarch to Jefferson, the capital of the fictional Yoknapatawpha County, in order to fulfill the promise to bury her with the rest of her family. Later on, it is observed that what might be called a genuine odyssey is not finished by most of the Bundrens for honor of the memory of the mother, but because of their personal ambitions. While the other Bundrens, in schopenhaeurian terms, remain trapped in the world of concept and abstraction, Darl contemplates the same objects for their truth, disregarding the superficial reflection on the utility that they would have in the phenomenal world. Thus, the character could be compared to the genius, the pure subject of knowing (SCHOPENHAUER, 2005, p. 254), the only one who has an artistic sensibility and surrenders to his tragic destiny because the world to which his family is confined is not his world (FAULKNER, 2002, p. 223). In order to make this approximation between Schopenhauer's thought and the Faulknerian hero, this dissertation is divided into four chapters. The introductory chapter briefly discusses the American modernist movement, its historical context, the problems addressed in it, and its diversity of themes. In addition, it discusses Faulkners context of production, with an extensive literature review on the specificities of his work and his main literary concerns. A literature review of As I Lay Dying is offered in the first chapter. In the second one, a description of The World is presented in order to better understand the theory of the genius. Here, the objective is also to connect Schopenhauer's philosophy to the work of Faulkner through the discussion of works that have managed to intersect one or another of his aesthetic concerns to the premises of the Frankfurt philosopher. Finally, in the third chapter, an analysis of the novel from the schopenhauerian notion of the genius is performed.
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Herndon, Karlie E. "Food and power in Roald Dahl's James and the giant peach and Neil Gaiman's Coraline." View electronic thesis (PDF), 2009. http://dl.uncw.edu/etd/2009-1/herndonk/karlieherndon.pdf.
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Banna, Christopher David. "Characterization of DAP1/YPL170W: the Saccharomyces cerevisiae Membrane Associated Progesterone Receptor (MAPR)Homologue." Diss., Georgia Institute of Technology, 2005. http://hdl.handle.net/1853/6826.
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Characterization of DAP1/YPL170W: the Saccharomyces cerevisiae Membrane Associated Progesterone Receptor (MAPR) Homologue
Christopher D. Banna
135 pages
Directed by Dr. Jung H. Choi
MAPRs (Membrane Associated Progesterone Receptors) from several sources have been isolated, studied and minimally characterized in mammalian systems, yet the specific role of this protein family has not been fully determined. Early worked characterized this protein family as a type of steroid binding protein, unrelated to the classical nuclear receptors, and linked this family to non-genomic cellular responses. The MAPR homologues as a group have been suggested to play widely varying roles from axon guidance and neuronal formation, to steroid hydroxylation, to influencing reproductive behavior. Their specific role has not yet been clearly demonstrated in any organism. There is some debate as to whether MAPRs do indeed bind steroid compounds, but there is clear evidence this family of proteins is involved in steroid perception. Recent work has begun to link a specific member of the MAPR family, IZAg from rat, to steroid metabolism/production, specifically, in the hydroxylation step of glucocorticoid production from progesterone. In the yeast Saccharomyces cerevisiae, the MAPR homologue is DAP1. Preliminary work on haploid strains demonstrated several phenotypes associated with the DAP1 deletion mutant, most notably an altered sterol profile. Previous characterization of diploid homozygous mutant strain has shown a differential sensitivity to alcohol, an altered sterol profile, and a strong yeast two-hybrid interaction with Ypr118wp; methylthioribose-1-phosphate isomerase. Work in this study link the localization of Dap1p to lipid particles and on the ER, both sites of sterol synthesis. The sterol profiles of the control strain and the dap1Ġdeletion mutant strain were examined in detail. The most notable difference was the presence of an additional sterol compound associated with the deletion mutant strain. The structure of this compound does not correspond to normal sterols in the ergosterol biosynthetic pathway, but does correspond to structure of sterols in so-called alternate aberrant sterol pathways. The data presented in this study demonstrates that Dap1p was involved in sterol processing, although its specific role is unknown. Two possible scenarios are proposed; one where Dap1p is involved in regulating the flux of sterols from one internal membrane to another, and another where Dap1p is involved in aberrant sterol pathways.
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Ghia, Guido. "Fichte nella teologia : dall'"Atheismusstreit" ai giorni nostri /." Milano : Guerini e associati, 2003. http://catalogue.bnf.fr/ark:/12148/cb39177994k.
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Texte remanié de: Diss.--Bochum--Ruhr-Universität. Titre de soutenance : J. G. Fichte und die Theologie : Elemente und Figuren einer theologischen Rezeptions- und Wirkungsgeschichte der Philosophie und Theologie Fichtes.Notes bibliogr.
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Rosa, Cayo Candido. "Gustavo Dahl e a Embrafilme: discurso e prática." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/8/8138/tde-12122016-111021/.
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O presente trabalho tem por objetivo estudar a trajetória de Gustavo Dahl com ênfase nos anos de 1960 e 1970, quando atuou, em diferentes medidas, como cineasta, crítico e teórico de cinema e gestor da Embrafilme (Empresa Brasileira de Filmes S/A). Levando em conta o turbulento contexto histórico estudado, que abarca os anos que precedem até mais da metade do que se configurou como o Regime Militar, buscamos delinear como suas ideias e textos escritos ao longo do recorte estudado se configuraram na prática quando era responsável pela área de distribuição da companhia estatal Embrafilme, levando em consideração sua concepção de mercado e suas influências, tanto no campo cinematográfico quanto nas esferas de poder.This study aims to analyse the life of Gustavo Dahl focusing in the 1960s and 1970s when he acted as a filmmaker, film critic and manager of Embrafilme (Empresa Brasileira de Filmes S/A). Taking into consideration the turbulent historical context ranging from the year before and during the military rule in Brazil, we try to understand how his ideas and articles written throughout the years in questions were put into practice when he was responsible for the distribution of films at the state company also taking into consideration his conception of market and his influences in the cinema fields and also in the high levels of power.
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Bozzato, Luca. "Metodi perturbativi dipendenti dal tempo." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amslaurea.unibo.it/7682/.
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Sono rari i problemi risolubili in maniera esatta in meccanica quantistica. Ciò è legato alle
difficoltà matemtiche insite nella teoria dei quanti. Inoltre i problemi risolti, pur essendo in
alcuni casi delle ottime approssimazioni, sono spesso delle astrazioni delle situazioni reali. Si
pensi ad esempio al caso di una particella quantistica di un problema unidimensionale. Questi
sistemi sono talmente astratti da violare un principio fondamentale, il principio di indetermi-
nazione. Infatti le componenti dell’impulso e della posizione perpendicolari al moto sono nulle
e quindi sono note con certezza ad ogni istante di tempo. Per poter ottenere una descrizione
dei modelli che tendono alla realtà è necessario ricorrere alle tecniche di approssimazione.
In questa tesi sono stati considerati i fenomeni che coinvolgono una interazione variabile nel
tempo. In particolare nella prima parte è stata sviluppata la teoria delle rappresentazioni della
meccanica quantistica necessaria per la definizione della serie di Dyson. Questa serie oper-
atoriale dovrebbe convergere (il problema della convergenza non è banale) verso l’operatore
di evoluzione temporale, grazie al quale è possibile conoscere come un sistema evolve nel
tempo. Quindi riuscire a determinare la serie di Dyson fino ad un certo ordine costituisce una
soluzione approssimata del problema in esame.
Supponiamo che sia possibile scomporre l’hamiltoniana di un sistema fisico nella somma di
due termini del tipo:
H = H0 + V (t),
dove V (t) è una piccola perturbazione dipendente dal tempo di un problema risolubile esattamente caratterizzato dall’hamiltoniana H0 . In tal caso sono applicabili i metodi della teoria
perturbativa dipendente dal tempo. Sono stati considerati due casi limite, ovvero il caso in cui
lo spettro dell’hamiltoniana imperturbata sia discreto e non degenere ed il caso in cui lo spettro
sia continuo. La soluzione al primo ordine del caso discreto è stata applicata per poter formu-
lare il principio di indeterminazione energia-tempo e per determinare le regole di selezione
in approssimazione di dipolo elettrico. Il secondo caso è servito per spiegare il decadimento
beta, rimanendo nel campo della teoria quantistica classica (per una trattazione profonda del
problema sarebbe necessaria la teoria dei campi).
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Bertozzi, Michela. "Proposta di traduzione dal tedesco di quattro arie dal Singspiel "Die Zauberflöte" di W.A. Mozart." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2019.
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Nel presente elaborato, si è scelto di addentrarsi nel mondo della traduzione per l'opera.
Vengono proposte due traduzioni, rispettivamente una traduzione "cantabile" e una traduzione letteraria, per ciascuna delle quattro arie estratte dal Singspiel "Die Zauberflöte" ("Il Flauto magico") di W.A. Mozart, su libretto di E. Schikaneder. Le traduzioni sono seguite da un commento a motivazione delle scelte traduttive e introdotte da un capitolo dedicato alla traduzione in ambito operistico, nonché da una breve analisi dell'opera in questione, passando per le sue origini e i suoi contenuti.
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Gao, Yong. "Synthesis of diaminopimelic acid (DAP) and analogues, mechanistic studies on dap aminotransferase, epimerase and dehydrogenase." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ34768.pdf.
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Betke, Anja. "Roald Dahl: schwarzer Humor in der Kinder- und Jugendliteratur." [S.l. : s.n.], 2003. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB11675655.
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Sequeira, Joana Brito. "Estudo epidemiológico de espécies de Culicoides capturados perto de equinos no noroeste da Alemanha." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2020. http://hdl.handle.net/10400.5/20421.
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Dissertação de Mestrado Integrado em Medicina VeterináriaO cavalo é um animal muito importante na cultura e na economia alemã, sendo várias as utilizações do equino neste país, assim como as oportunidades de negócio ligadas ao setor equestre. As diferentes doenças que podem afetar estes animais têm, um impacto direto nos seus proprietários, principalmente a nível económico. De entre várias doenças que podem afetar os equinos, pode-se mencionar a dermatite alérgica à picada de Culicoides (DAPC) ou hipersensibilidade à picada de insetos (HPI). Os objetivos deste trabalho foram perceber quais as espécies de Culicoides presentes perto de equinos no noroeste da Alemanha e qual a proporção de DAPC na mesma área. Os insetos foram capturados em sete locais diferentes, no estado de Nordrhein Westfalen, Alemanha, com recurso a armadilhas do tipo miniature CDC light trap, num total de 30 capturas, tendo sido registados todos os fatores bióticos e abióticos observados durante os períodos de captura, entre 26 de setembro e 15 de dezembro de 2019. Foram também distribuídos panfletos informativos e questionários a tutores de equinos, para avaliar a proporção de DAPC nesta área, as alturas do ano em que a mesma se manifesta e como eram mantidos os animais afetados, assim como perceber o impacto desta doença ao nível do desempenho do equino e o impacto económico da mesma para os tutores. Um total de 195 insetos foram capturados perto de equinos, tendo sido identificadas as seguintes espécies: C. obsoletus, C. scoticus, C. dewulfi, C. chiopterus, C. pulicaris, C. punctatus, C. festivipennis; a espécie mais abundante foi C. scoticus. Foi também observado, no decorrer deste estudo, um intervalo de temperaturas de atividade para a espécie C. dewulfi (8 ºC – 18 ºC) e para a espécie C. chiopterus (8 ºC – 20 ºC) diferente dos intervalos reportados na bibliografia. Encontrou-se uma proporção de DAPC de 37,1% (n=13), sendo este um problema reconhecido pela maioria das pessoas questionadas durante este estudo. Conclui-se que o uso de repelentes e proteções mecânicas não é totalmente eficiente para evitar o contacto com os insetos e que a afeção não é sazonal na Alemanha, levando à perda de performance desportiva nos equinos. As despesas dos tutores com a doença relacionaram-se com as medidas profiláticas tomadas e com o alívio básico dos sinais clínicos, variando este custo entre os 20 € e os 250 €/animal/ano. Apesar de nenhum dos tutores questionados ter recorrido a tratamentos mais dispendiosos, como a imunoterapia, as despesas diferem consoante a abordagem tida pelos mesmos, podendo vir a ser ainda mais elevadas.
ABSTRACT - Epidemiological study of Culicoides species captured near horses in north-west Germany - The horse is a very important animal in German culture and economy, since horses can be used for multiple purposes in this country, as well as business opportunities related to the equestrian sector. The different pathologies that can affect these animals have a direct impact on their owners, mainly at the economical level. Among several diseases that can affect equines, one can mention the biting midges’ allergic dermatitis (BMAD) or insect bite hypersensitivity (IBH), caused by insects of the genus Culicoides. The objectives of this study were to understand which Culicoides species were present near equines in northwestern Germany and what is the relative prevalence of IBH in the same area. The insects were captured at seven different sites in the state of Nordrhein Westfalen, Germany, using miniature CDC light traps, in a total of 30 captures. All biotic and abiotic factors observed during the capture periods, which took place between September 26th and December 15th 2019, were registered. Informational flyers and questionnaires were also distributed to the guardians of the horses to assess the relative prevalence of IBH in this area, its seasonality and how the affected animals were kept, as well as to understand the impact of this disease on the equine performance and its economic impact on guardians. A total of 195 insects were caught near equines, and the following species were identified: C. obsoletus, C. scoticus, C. dewulfi, C. chiopterus, C. pulicaris, C. punctatus, C. festivipennis; the most abundant species was C. scoticus. The temperature range of activity found during this study for C. dewulfi (8 ºC - 18 ºC) and for C. chiopterus (8 ºC - 20 ºC) was different from the ranges reported in the bibliography. A proportion of BMAD of 37.1% (n=13) was found, being the problem recognised by the majority of people questioned during this study. It was concluded that the use of repellents and mechanical protections is not fully efficient to avoid contact with insects and the disease is not seasonal in Germany, leading to loss of horse’s sport performance. Guardians expenses with the disease focused on prophylactic means and basic clinical signs relief methods and ranged from €20 to €250. Although none of the guardians questioned had resort to more expensive treatments such as immunotherapy, the costs differ according to the approach taken by them and may be even higher than the ones mentioned.
N/A
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Szuber, Maria. "Hornswogglers, whangdoodles and other dirty beasts : the comic grotesque in Roald Dahl's writings for children." Thesis, McGill University, 1999. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=30223.
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The purpose of this thesis will be to substantiate the claim that Roald Dahl, the author of humorous writings for children, is simultaneously an avid creator of grotesque fiction. My argument is based on the premise that unless one views Dahl's texts in terms of their grotesque influence, critical evaluation of his work inevitably becomes reduced to a question of taste. A diachronic overview of the term "grotesque" is presented beginning with its delineation of an artistic mode in early Rome to its Rabelaisian extensions during the sixteenth century. The origins of the word are established, and its changing meaning throughout history is examined. A synchronic approach to the study follows, tracing both modern and post-modern theories of the grotesque. Of particular importance to the survey is Bakhtin's Rabelais and His World. By emphasizing the "positive, regenerating, creative" powers of laughter, Rabelais comes closest to defining the comic grotesque as embodied in Dahl's fiction. The final portion of the thesis is devoted to an interpretation of such texts as The Twits, George's Marvelous Medicine, and Charlie and the Chocolate Factory. Dahl's treatment of character, his development of plot, and his use of language are discussed in relation to previous theories of the grotesque. A psychological defense of the genre is offered as a conclusion to the study. Ultimately, the grotesque will be viewed in its cathartic role: helping children work through feelings of oppression in a world governed by adult authority.
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Van, Renen Charles Gerard. "A critical review of some of Roald Dahl's books for children, with particular reference to a 'subversive' element in his writing, some responses to his work and its place in the education of the child." Thesis, Rhodes University, 1986. http://hdl.handle.net/10962/d1003367.
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Tong, Amy. "Caenorhabditis Elegans DAPK-1 functions in epidermal damage responses /." Diss., Digital Dissertations Database. Restricted to UC campuses, 2008. http://uclibs.org/PID/11984.
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Swei, Allen. "Mechanisms of oxidative stress in the Dahl hypertensive rat /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1997. http://wwwlib.umi.com/cr/ucsd/fullcit?p9820855.
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Quezada, Sepúlveda Álvaro. "La teoría pluralista de Robert Dahl: un análisis filosófico." Tesis, Universidad de Chile, 1996. http://repositorio.uchile.cl/handle/2250/134953.
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Magíster en Filosofía con mención en axiología y filosofía política.La primera pregunta que resulta forzoso hacer reza: ¿es necesaria una filosofía política en la actualidad? Y ello porque, más allá del actual descrédito de la política y los políticos, tal actividad se nos muestra, con su trivialidad y su espacio de opinión e ignorancia, como lo más alejado de la venerada y vetusta filosofía. La pregunta no es ociosa, de hecho la política tiene un lugar en la filosofía; tanto desde el punto de vista histórico como sistemático, hay una filosofía que se ocupa de lo político. En seguida, también, ¿necesita lo político (o la política) de una filosofía?, ¿necesitan los políticos de los filósofos? ¿Pueden existir y sobrevivir los sistemas políticos, las políticas y los políticos sin una filosofía? Este conjunto de cuestiones quiero implicar cuando pregunto si es necesaria una reflexión política en nuestra época actual.
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Huenemann, Jeannine. "Going Solo with Roald Dahl: Life Rewritten Through Memory." DigitalCommons@USU, 2011. https://digitalcommons.usu.edu/etd/1003.
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Roald Dahl does not easily fit into a category as a writer, contributing fiction and nonfiction to both children and adult audiences. Faced with this ambiguity, the literary community has mostly ignored his contributions since he is mainly viewed as a children‘s author. Late in life, Dahl created two autobiographies, Boy: Tales of Childhood (1984), and Going Solo (1986), as venues for sharing his many embellished, personal stories. This thesis focuses on Going Solo, the second of these two books which explores Dahl‘s three-year departure from England, including his enlistment in the Royal Air Force during World War II. During this same time period, he wrote 126 personal letters and telegrams to his family. He had experienced much change in his life during the nearly fifty-year gap from when the letters were written to when he crafted Going Solo for a more general audience. By comparing this personal correspondence to Going Solo, it is possible to see how memory and self-selection permitted the author to craft a personal narrative interested as much in reconstructing his public persona as recounting true events from his past.
This thesis asserts that Dahl does not rely exclusively on his letters when reconstructing the narrative and instead inserts himself into a larger historical narrative. Dahl used Going Solo to point to the locations where his personal narrative collides with history and emotions. This is particularly true in the last half of the book where he comes to rely on historical touchstones. It is full of places and people which evoke memories and strong feelings for him. Dahl also relied on techniques and motifs found in folktales, features that make his work of particular interest to folklorists. The final chapter offers an examination of these techniques used in The BFG, Dahl‘s most autobiographical work of children‘s literature, written only four years prior to Going Solo. By paying closer attention to his methodology, we gain a clearer understanding of how folklore functions in the development of literary personal narrative.
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Günther, Susanne. "Population structure and dynamics of polyphosphate accumulating organisms in a communal wastewater treatment plant." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-89984.
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Polyphosphat-speichernde Bakterien entfernen das im Abwasser enthaltene Phosphat durch Speicherung in Form von Granula, die dann mit einem Teil des Belebtschlammes aus dem Abwasser entfernt werden können. Dies ist wichtig um negative Einflüsse auf Oberflächengewässer wie Flüsse und Seen so gering wie möglich zu halten. Trotz intensiver Forschung ist der Prozess der sogenannten biologischen Phosphatelimination oft uneffektiv und im Jahresverlauf instabil, da über die im Belebtschlamm aktiven Polyphosphat-speichernden Bakterien nur wenig bekannt ist. Hauptproblem ist hierbei die geringe Kultivierbarkeit der Bakterien unter definierten Bedingungen (nur etwa 10-15 % der Mikroorganismen im Belebtschlamm sind kultivierbar). Aus diesem Grund war das Ziel der Arbeit die aktiven, Polyphosphat-speichernden Bakterien durchflusszytometrisch zu bestimmen und deren Dynamiken im Belebtschlamm kultivierungsunabhängig zu messen.
Zunächst wurde ein Fixierungsprotokoll für die durchflusszytometrische Untersuchung der Polyphosphat-speichernden Bakterien erarbeitet, welches die größtmögliche Stabilität der hochdiversen mikrobiellen Gemeinschaft in Belebtschlammproben gewährleistet. Eine Mischung aus den Metallen Barium und Nickel (jeweils 5 mM) in einer 10%igen Natriumazidlösung erwies sich als bestes Fixierungsmittel mit einer Belebtschlamm-Stabilität von mindestens 9 Tagen. Um sowohl den DNA-als auch den Polyphosphat-Gehalt der Zellen messen zu können wurde weiterhin eine neue und sehr spezifische Polyphosphatfärbung auf Basis des fluoreszierenden Antibiotikums Tetrazyklin etabliert. Tetrazyklin bindet divalente Kationen, die auch in großer Menge in Polyphosphatgranula enthalten sind und fluoresziert gelblich grün. Die entwickelten Methoden zur Fixierung und Polyphosphatfärbung wurden an Belebtschlamm einer kommunalen Kläranlage getestet. Neben DNA- und Polyphosphat-Gehalt der Bakterienzellen wurde eine Vielzahl abiotischer Parameter (pH, Temperatur, Leitfähigkeit, …) gemessen. Diese wurden zusammen mit den durchflusszytometrischen Daten mittels Korrelationsanalyse ausgewertet. Hieraus ergaben sich wichtige Hinweise auf die Art der Polyphosphat-speichernden Bakterien, fördernde und störende Einflüsse des in der Kläranalage behandelten Abwassers auf die biologische Phosphatelimination und die Abhängigkeiten der mikrobiellen Gemeinschaft von Faktoren wie Temperatur, pH oder der anfallenden Regenmenge. Diese Erkenntnisse können genutzt werden um die biologische Phosphatelimination aus dem Abwasser zu verbessern und damit den Weg zu einer Ressourcen- und Umweltschonenden Phosphatrückgewinnung zu bereiten. Außerdem ist es, bei Kenntnis des kläranlagenspezifischen Prozesses, möglich anhand der durchflusszytometrischen Daten schnell die aktuelle Situation zu erfassen und gegebenenfalls rechtzeitig auf Änderungen zu reagieren, bevor es zu einer massiven Störung kommt.
Eine Kombination von Durchflusszytometrie und der Erfassung abiotischer Daten ist nicht nur auf die biologische Phosphateliminierung anwendbar, sondern auch auf viele andere wissenschaftliche Fragestellungen.
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Kupčinskaitė, Rita, and Rita Kupčinskaitė-Noreikienė. "Genų, susijusių su apoptoze ir dnr pažaidų atitaisymu, metilinimo ypatumai skrandžio onkogenezės pakopiniame procese." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2013. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130919_143632-54949.
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DNR pažaidų atitaisymas ir apoptozė - dvi pagrindinės grandys, palaikančios žmogaus genomo vientisumą. Sutrikus šiems procesams, ląstelė išgyvena, nepaisant susikaupusių DNR pažaidų ir sudaromas pagrindas tolesnei transformacijai. Tyrimu įvertinome DNR pažaidų atitaisymo funkcijoje dalyvaujančių (hMLH1, MGMT) ir su apoptoze susijusių (DAPK-1, CASP8) genų epigenetinio reguliavimo - metilinimo aspektus pakopiniame skrandžio onkogenezės procese. Šio mokslinio tyrimo metu pirmą kartą buvo nustatytas skirtingas hMLH1 geno metilinimo dažnis atskirose skrandžio anatominėse dalyse atrofiniu pangastritu sergančiųjų audinyje. Įvertinta, kad hMLH1 geno metilinimas sergančiųjų skrandžio vėžiu aplinkiniame nenavikiniame audinyje sietinas su pacientų amžiumi. Išgyvenamumo analizės rezultatai parodė, kad MGMT geno metilinimas agresyvios skrandžio vėžio histologinės formos atveju yra geresnės prognozės rodiklis. Tyrimo metu nustatėme mokslinėje periodikoje neaprašytų tirtųjų genų metilinimo derinių sąsajų su klinikiniais, morfologiniais ir prognoziniais onkologinės ligos ypatumais.DNA repair and apoptosis are two main pathways supporting the integrity of human genome. After the disturbance of these processes the cell survives, despite the accumulation of DNA lesions, and in this way a basis for a subsequent transformation is formed. In our research we evaluated the epigenetic regulation - methylation - aspects of genes participating in DNA repair function (hMLH1 and MGMT) and also of apoptosis-related genes (DAPK-1, CASP8) in relation to a stepwise gastric oncogenesis process. During this investigation a different hMLH1 gene methylation observation frequency in tissues obtained from separate anatomical parts of the stomach in atrophic pangastritis patients was determined for the first time. It was estimated, that hMLH1 gene methylation in tumor-surrounding non-cancerous tissue in gastric cancer patients could be associated with patient age. Results of survival analysis indicated that MGMT gene methylation is an indicator of better prognosis in case of diffuse form of gastric cancer. During the study we determined some additional associations (not described in previous publications) between methylation combinations of analyzed genes and clinical, morphological and prognostic features of oncological illness.
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Pereira, Antonio Kevan BrandÃo. "Teoria DemocrÃtica ContemporÃnea: o conceito de poliarquia na obra de Robert Dahl." Universidade Federal do CearÃ, 2013. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=12225.
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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgicoEste trabalho analisa o conceito de poliarquia na obra de Robert Dahl. O autor faz uma distinÃÃo entre âdemocracia idealâ e âdemocracia realâ. Para ele, a palavra âdemocraciaâ evoca o cenÃrio grego original de participaÃÃo direta, nÃo sendo mais adequada para classificar os regimes representativos contemporÃneos. Tais regimes sÃo pobres aproximaÃÃes dos ideais democrÃticos, e que por isso devem ser classificados como âpoliarquiasâ. Por meio de uma pesquisa bibliogrÃfica, o trabalho objetiva evidenciar e analisar, mais especificamente, a investigaÃÃo que o autor realizou no seu clÃssico livro âPoliarquia: ParticipaÃÃo e OposiÃÃoâ, no qual ele abordou o tema da transiÃÃo de regimes, procurando compreender quais as condiÃÃes que favorecem ou impedem a transiÃÃo de um regime nÃo poliÃrquico para um regime poliÃrquico.
This paper analyzes the concept of polyarchy in the work of Robert Dahl. The author makes a distinction between "ideal democracy" and "real democracy". For him, the word "democracy" evokes the original Greek scenario of direct participation, no longer appropriate to classify regimes representative contemporaries. Such schemes are poor approximations of democratic ideals, and therefore should be classified as "polyarchies". Through a literature search, this work aims at identifying and analyzing more specifically, the research that the author conducted in his classic book "Polyarchy: Participation and Opposition," in which he addressed the issue of regime transition, trying to understand what conditions that favor or hinder the transition from a regime not polyarchical to a polyachical regime.
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Moruzzi, Lara. "Dal formalismo Hamiltoniano alla meccanica statistica." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/18212/.
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L'obiettivo di questa tesi è quello di descrivere i principi della meccanica statistica a partire da risultati della meccanica hamiltoniana. Si tratta soprattutto di arrivare a formulare delle definizioni ragionevoli delle variabili macroscopiche della termodinamica (quali l’entropia e la temperatura) a partire da quelle microscopiche (quali il flusso hamiltoniano). Si dà una particolare attenzione allo studio di sistemi isolati (per i quali viene definita la statistica microcanonica) e a quella di sistemi in interazione con un réservoir (per i quali viene definita la statistica canonica). Alcuni esempi semplici vengono poi analizzati.
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Piani, Goffredo. "Sull'interferenza quantistica indotta dal potenziale gravitazionale." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/19167/.
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Con l’avvento della meccanica quantistica è emerso un nuovo parametro che non ha alcun equivalente nella meccanica classica. La fase di un’onda di materia. Essa è direttamente influenzata dal potenziale cui l’onda è sottoposta, dunque anche dal potenziale gravitazionale.
Colella, Overhauser e Werner in uno storico esperimento del 1975 ne introdussero una modalità di verifica che prevede un’interferometria su di un fascio di neutroni. Infatti, i due rami dell’interferometro, se soggetti a un livello differente di potenziale, producono una figura di interferenza.
In questa tesi sono trattati i vari fattori che influenzano gli esperimenti COW. A fianco degli effetti gravitazionali, vi sono quelli causati dalla rotazione terrestre, quelli dovuti alla deformazione del cristallo interferometrico e quelli introdotti dalla teoria della dynamical diffraction.
Infine viene descritta, una tra le tante, l’applicazione di questa tipologia di esperimenti nella verifica del principio di equivalenza in ambito quantistico.
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Assenza, Concetta. "La canzonetta dal 1570 al 1615 /." Lucca : Libreria musicale italiana, 1997. http://catalogue.bnf.fr/ark:/12148/cb36999066q.
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Gioventu, Alessandra. "Neutrini dal piano galattico con ANTARES." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amslaurea.unibo.it/9586/.
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In questa tesi si cerca un flusso diffuso di neutrini nel piano Galattico. ANTARES, un telescopio di neutrini che si trova nel Mar Mediterraneo, ha un’area di visibilit`a tale da poter osservare questa parte di cielo, quindi isolare l’emissione di neutrini per trovarne le sorgenti. Sono confrontate diverse regioni del cielo, selezionate in modo tale che abbiano le stesse dimensioni. In particolare si comparano la regione corrispondente al Centro Galattico, detta on-zone, e altre regioni, dove secondo i modelli analizzati ci si aspetta un minor segnale, dette off-zone.
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Veres, Michael J. "The Saguwentje of Berg En Dal." Kent State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=kent1353550765.
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Drago, Gene K. "Studies Directed to the Optimization of Fermentation of Rhodococcus sp. DAP 96253 and Rhodococcus rhodochrous DAP 96622." Digital Archive @ GSU, 2007. http://digitalarchive.gsu.edu/biology_diss/24.
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Studies Directed to the Optimization of Fermentation of Rhodococcus sp. DAP 96253 and Rhodococcus rhodochrous DAP 96622 by GENE KIRK DRAGO Under the Direction of George E. Pierce ABSTRACT Bench- and pilot plant scale fed-batch fermentations were performed in stirred-tank bioreactors (STBR) with Rhodococcus sp. DAP 96253 and R. rhodochrous DAP 96622 in an attempt to elucidate parameters that may affect the optimization of a fermentation process for high biomass production and high inducible expression of cobalt-high-molecular-mass nitrile hydratase (Co-H-NHase. The effects of these factors on amidase (AMDase) activity were also investigated. Biomass and NHase production were inhibited by a total addition of acetonitrile and acrylonitrile (AC / AN) at 500 ppm during a 48 h run. Biomass and enzyme activity were uncoupled when the inoculum mass was increased from 4 g (wet weight) to ¡Ý 19 g. Other factors that allowed for the uncoupling of biomass production from enzyme activity were the reduction of the AC / AN feed rate from a step-addition at 2500 ¦Ìl / min to a continuous addition at 80 ¨C 120 ¦Ìl / min, and the delay to 18 h post-inoculation the time of initial inducer addition. The inhibition of both biomass production and NHase activity was relieved when both the total concentration of AC / AN was reduced to ¡Ü 350 ppm and the AC / AN feedrate was reduced. The factors with the greatest influence were shown to be the inducer, the inducer concentration, inoculum mass and source as well as the major carbohydrate and nitrogen source. In addition, this lab is the first to report high AN-specific NHase induction by asparagine (1300 ppm) in a fed-batch fermentation system. Prior to this program, 250 mg of cells (wet weight) per liter could be provided in 4 ¨C 10 days with an activity of 1 U NHase per mg of cells (dry weight). Current production is > 50 g / L in 48 h with an NHase activity > 150 U / mg of dry cell weight. INDEX WORDS: Amidase, Asparagine, Biodetoxification, Fermentation, Nitrile, Nitrile Hydratase, Rhodococcus
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Romera, Lavínia Maria Dal\'Mas. "Caracterização da inter-relação entre as vias de sinalização Notch e TLR na paracoccidioidomicose experimental." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/9/9142/tde-22122016-113633/.
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A paracoccidioidomicose é uma micose sistêmica de natureza profunda que afeta preferencialmente o tecido pulmonar podendo disseminar via linfo-hematogênica para outros órgãos e tecidos, sendo causada principalmente pelo Paracoccidioides brasiliensis, fungo que apresenta dimorfismo térmico. O sistema imune inato mediado por macrófagos é extremamente importante para o controle de infecções e está envolvido na indução e regulação da resposta imune/inflamatória. Estas células são capazes de reconhecer patógenos por meio de receptores de reconhecimento de padrões (PRRs), tais como receptores Toll-like (TLR). Além desses PRRs, recentemente, demonstrou-se a importância da via de sinalização Notch no sistema imune inato e na regulação da atividade dos macrófagos. Nossos dados demonstram que a cepa Pb18 do P. brasiliensis é capaz de ativar o receptor Notch1 em macrófagos J774. A ativação desse receptor concomitante com a ativação de TLR 4 (via LPS) induz a produção de IL-6, e apresenta elevada carga fúngica e menor fagocitose, o que favorece a patogenia. Ao utilizarmos um inibidor farmacológico da γ-secretase (DAPT) para inibir a ativação do receptor Notch1 em macrófagos, é possível observar diminuição da carga fúngica, diminuição de IL-6, aumento de TNF-α e aumento da fagocitose. Entretanto, a ausência do receptor TLR 4 em macrófagos derivados de medula óssea de camundongos TLR 4-/-, na presença de DAPT, percebe-se diminuição da capacidade fagocítica desses macrófagos e também diminuição da carga fúngica, evidenciando a relação entre TLR 4 e Notch1. Em adição, realizamos um tratamento em camundongos BALB/c com DAPT previamente à infecção com Pb18. Nossos resultados evidenciaram que animais com este tratamento apresentaram diminuição da carga fúngica dos pulmões, diminuição de IL-6, ativação de macrófagos e aumento de IgG, após 45 dias de infecção, indicando um perfil de cura desses animais. O mesmo tratamento foi realizado em camundongos BALB/c NUDE, seguido da infecção com Pb18. Nestes animais, verificamos que há maior produção de citocinas pró-inflamatórias no pulmão, aumento de células CD19+ e a carga fúngica dos animais tratados manteve-se similar ao dos animais não tratados, indicando que o perfil protetor observado em animais com DAPT é dependente da resposta das células T. Juntos, esses resultados evidenciam que o Pb18 é capaz de ativar o receptor Notch1 em macrófagos e utiliza a via de sinalização Notch-TLR 4 como um possível mecanismo de escape, podendo fornecer uma nova abordagem de estudo da imunidade envolvida na paracoccidioidomicose experimental.Paracoccidioidomycosis is a systemic mycosis of deep nature that primarily affects the lung and can spread via lymphatic and hematogenous to other organs and tissues. It is mainly caused by Paracoccidioides brasiliensis fungus which exhibit thermal dimorphism. The innate immune system mediated by macrophages is extremely important for the control of infection and is involved in the induction and regulation of immune/inflammatory response. These cells are able to recognize pathogens through pattern recognition receptors (PRRs) such as Toll-like receptors (TLR). Beyond these PRRs, the importance of Notch signaling has recently been demonstrated in the innate immune system and the regulation of macrophage activity. Our data demonstrate that the Pb18 strain of P. brasiliensis is able to activate the Notch1 receptor in J774 macrophages. Activation of this receptor with also activation of TLR 4 (via LPS) induces IL-6 production, induces phagocytosis and decreases fungal burden, which favors the pathogenesis. By using a γ-secretase pharmacological inhibitor (DAPT) for inhibiting the activation of Notch1 receptor on macrophages, it is possible to observe decreased fungal burden, less production of IL-6, and increased TNF-α and phagocytosis. However, due to the absence of TLR 4 receptor in bone marrow derived macrophages from TLR 4-/- mice, these macrophages showed decreased phagocytic ability and also reduced fungal burden in the presence of DAPT, showing a relationship between TLR 4 and Notch1. In addition, we made a treatment with DAPT in BALB/c mice prior to infection with Pb18. And our results showed that DAPT-treated animals exhibited a decrease of fungal burden in the lungs, and a decrease of IL-6. Furthermore, we observed an increase of IgG after 45 days of infection, indicating probably a healing of these animals. Same treatment was made in BALB/c NUDE mice, followed by infection with Pb18. In these animals, we observed an increased production of proinflammatory cytokines in the lung and increased CD19+ cells, but fungal burden was similar in both group (treated and untreated), which indicates that treatment with DAPT is dependent on T cell response. Taken together, these results showed that Pb18 is able to activate the Notch 1 receptor on macrophages and uses the Notch-TLR 4 signaling pathway as a possible escape mechanism, and may provide a new immunity study approach in experimental paracoccidioidomycosis.
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de, Assis Oliveira Coutinho Junior Francisco. "Teoria política e participação democrática : Dahl e a democracia em diferentes escalas." Universidade Federal de Pernambuco, 2011. https://repositorio.ufpe.br/handle/123456789/1871.
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Previous issue date: 2011Conselho Nacional de Desenvolvimento Científico e Tecnológico
A democracia é, atualmente, um dos temas mais recorrentes no âmbito da Ciência Política. Autores diversos têm contribuído, ao longo de décadas, na elucidação de múltiplos problemas relacionados àquela forma de governo, tendo destaque os trabalhos do teórico norte americano Robert Dahl, que tem se destacado, dentre outros motivos, pelo enfoque apresentado sobre o tema da relação entre democracia e escala. Sobre a questão da democracia, do ponto de vista analítico, não se pode perder de vista a sua relação histórica com a problemática das unidades políticas, ou seja, a ligação entre regime democrático e tamanho espacial, o que inclui a dimensão geográfica e populacional do sistema. Para Dahl, em muitas de suas obras, a construção da democracia encontra-se estreitamente relacionada ao ambiente em que ela se propõe ser aplicada. Assim, define esse autor, sempre tendo em mente a questão do espaço, a existência de vários modelos de democracia, apropriados para cada escala - desde a pequena à grande unidade. Assim sendo, é nosso objetivo analisar, na presente dissertação, a reflexão de Dahl sobre a questão da relação entre democracia e escala. Deste modo, visamos também compreender os tipos de regimes democráticos desenvolvidos por este cientista político e a relação destes regimes com o tamanho das unidades políticas em que eles são consagrados
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da, Silva Calixto Merilane. "Análise citogénetica comparativa entre Glossophaga soricina, Platyrrhinus lineatus e Sturnira lilium (Phyllostomidae, Chiroptera)." Universidade Federal de Pernambuco, 2008. https://repositorio.ufpe.br/handle/123456789/6236.
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Previous issue date: 2008Cromossomos mitóticos de Glossophaga soricina (2n=32,XY; NF=60), Platyrrhinus lineatus e Sturnira lilium (2n=30,XY; NF=56) foram analisados através da coloração convencional, bandeamento C, impregnação com nitrato de prata (AgNO3) e fluorocromos base-específicos. Dados da análise convencional obtidos para as três espécies estão de acordo com aqueles descritos na literatura, exceto pela morfologia do cromossomo Y de P. lineatus, indicando variação cromossômica geográfica para a espécie. Os blocos de HC na região distal do braço curto dos pares 5, 6, 7 e cromossomo X, observados pelo bandeamento C, em P. lineatus e S. lilium, além da coloração diferencial do braço longo do cromossomo X de Sturnira lilium correspondem a um padrão compartilhado por alguns representantes de Stenodermatinae. A fraca marcação CMA3+ nas regiões heterocromáticas pericentroméricas e distais de alguns cromossomos indica uma predominante associação de heterocromatina com seqüências ricas em pares de bases GC. Contudo, os padrões diferenciais obtidos com o emprego de fluorocromos base-específicos confirmaram a heterogeneidade da HC quanto à sua composição (rica em AT e/ou GC) e comprovaram características diferenciais das seqüências intergênicas associadas às RONs (CMA3 positiva, negativa ou sem especificidade) em representantes de Phyllostomidae
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Paula, de Moraes Ana. "Utilização de marcadores cito-moleculares na identificação de cromossomos mitóticos em Citrus e Poncirus." Universidade Federal de Pernambuco, 2007. https://repositorio.ufpe.br/handle/123456789/667.
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Previous issue date: 2007Conselho Nacional de Desenvolvimento Científico e Tecnológico
A definição das espécies dentro dos gêneros pode ser problemática e as espécies de Citrus configuram um exemplo clássico de classificação conflitante. O presente estudo visou auxiliar na compreensão da sistemática deste grupo, ampliando a análise citogenética dos gêneros Citrus e Poncirus. Inicialmente foi analisada a variabilidade cariotípica dos pomelos (toranja × laranjadoce), indicando diferentes cariótipos entre as cultivares. Provavelmente, os diferentes cariótipos são resultantes de eventos de hibridação independentes, envolvendo diversos acessos de toranja. No entanto, as toranjas analisadas mostraram cariótipos idênticos e homozigotos, corroborando sua classificação como espécie pura. O segundo estudo dedicou-se à análise de 13 acessos de tangerinas. Em todos os acessos, o cromossomo D/5S-45S foi observado em homozigose e considerado um bom marcador para este grupo. A tangerina é classificada com uma das espécies puras, porém os dados obtidos sugerem que compreendam três espécies básicas: C. sunki, C. reshni e C. deliciosa, todas com cariótipos homomórficos, sendo que as duas primeiras foram idênticas. O terceiro trabalho visou refinar a análise cromossômica a partir da FISH de seqüências de cópia única. A espécie utilizada foi P. trifoliata, importante fonte de genes de resistência para Citrus. A análise da hibridização foi realizada comparativamente ao padrão de bandeamento CMA/DAPI e localização de sítio de DNAr 45S, permitindo reconhecer os nove pares cromossômicos, além de mapear a região de resistência ao VTC
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Franklin, Donald R. J. "DAPM, a dynamic associative priming model of immediate free recall." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ63305.pdf.
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Dahl, David [Verfasser]. "Electromagnetic Modeling and Optimization of Through Silicon Vias / David Dahl." Aachen : Shaker, 2018. http://d-nb.info/1162794062/34.
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Ruggiu, Matteo. "The function of DAZL and RBM, two candidate fertility genes." Thesis, Open University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300014.
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Carletti, Cecilia. "Turning Progettazione di un brick asettico dall' idea allo scaffale." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2016.
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Grenier, Alain Guy. "La valeur prédictive du modèle polyarchique de Robert A Dahl." Thesis, University of Ottawa (Canada), 1988. http://hdl.handle.net/10393/22122.
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Sousa, Martins Joao Pedro. "Functional analysis of DAZL-mediated translation activation during mammalian gametogenesis." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/9893.
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Gametogenesis is a highly complex process that requires stringent control of gene expression, in which translational regulation plays an essential role. Deleted in Azoospermia-like (DAZL) belongs to the DAZ family of RNA-binding proteins, which are restricted to germ cells, and regulate mRNA translation. Importantly, loss of function of these proteins results in infertility in both males and females in a wide variety of organisms. A model for the mechanism by which DAZL stimulates translation has been proposed based on work in Xenopus laevis (X. laevis) oocytes. In this model, DAZL functions by recruiting the translation initiation factor poly(A)-binding protein (PABP) to the 3’ untranslated region (UTR) of messenger RNAs. Simultaneous binding of PABP to Dazl and factors at the 5’ end confers a “closed-loop” mRNA conformation, which promotes translation initiation. To examine whether DAZL plays a similar role in mammals, co-expression of Dazl and PABP family members was investigated in fetal and adult mouse gonads. In contrast to X. laevis, mammals encode four cytoplasmic PABPs which share a similar domain organisation: PABP1, tPABP, ePABP and PABP4, of which PABP1 and PABP4 appear to be expressed in a wide range of tissues. Immunohistochemistry revealed that Dazl, Pabp1 and Pabp4 are all expressed in primordial germ cells (PGCs) but these show different expression patterns following germ cell sex differentiation. In adult testes Dazl is expressed in spermatogonia and spermatocytes, coinciding with the peak of Pabp4 expression. In contrast, the peak of Pabp1 expression occurs later than that of Dazl, with these proteins only being co-expressed in late pachytene and secondary spermatocyte phases. In adult ovaries, Pabp1, Pabp4 and Dazl are all expressed in the oocytes of primordial and primary follicles. Since both PABP family members are co-expressed with Dazl, the ability of DAZL to interact with PABP1 and PABP4 was investigated in vitro and in vivo. Surprisingly, these studies showed that DAZL discriminates between different PABP family members, only interacting with PABP1, providing the first report of a PABP-specific protein partner. Several putative DAZL mutations have been identified in patients with impaired fertility. Two of these mutations, I37A and R115G, are located in the RNA recognition motif (RRM), a domain which is found in many RNA-binding proteins and mediates both RNA and protein interactions. Thus, the role of these mutations in the ability of DAZL to stimulate translation was investigated. To this end, a translational target of human DAZL (hDAZL) was sought. The 3’UTR of growth differentiation factor 9 (hGDF9) mRNA was found to confer regulation by hDAZL and thus the ability of mutant DAZLs to stimulate reporter mRNAs containing this 3’UTR was examined. This revealed that both mutations compromised the ability of hDAZL to stimulate hGDF9 translation, suggesting a causative effect. These results were further confirmed in assays in which hDAZL is artificially tethered to mRNAs. The ability of mutant hDAZLs to stimulate translation in this assay was compromised suggesting that loss of function is, at least in part, due to impaired protein-protein interactions rather than altered RNA-binding. This work provides insights into the molecular mechanism by which DAZL stimulates the translation of specific mRNAs during mammalian gametogenesis and provides evidence that this function may play an important physiological role in human reproduction.
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Nilsson, Caroline. "Bortom historiens slut : En jämförande undersökning av nio U-länders demokratiska utveckling." Thesis, Växjö University, School of Social Sciences, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:vxu:diva-1432.
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Bortom historien slut – Beyond the end of history
According to Robert Dahl there are seven criteria that have to be fulfilled in order for a state to be democratic. Dahl also states that there are several factors that effect the development of democracy. In today’s world it is mostly developing countries that have failed to bring about democratic changes. It is the developing country that is in focus in this thesis.
The purpose is to examine if there are any particularly advantageous factors that can bring about or promote the development of democratic institutions.
The questions are:
What factor has effected the development of democratic institutions?
Which, if any, of Dahl’s seven criteria is found within each state today?; do they correctly reflect the democratic situation?
Can any connection between the states democratic development be found in a comparison?
In a comparison between nine countries the different factors have been examined. The result shows that pluralism is a key factor for development of democracy in a developing country. External influence is on the other hand not important.
Keywords: developing countries, democratization, Robert Dahl
Nyckerlord: utvecklingsländer, demokratisering
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Rowton, Sharon. "Pathological role of double-stranded DNA antibodies in multiple sclerosis." Thesis, University of Bradford, 2009. http://hdl.handle.net/10454/4293.
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Multiple sclerosis is a complex disease and one for which the aetiology remains largely unanswered. Anti-dsDNA antibodies have been found intrathecally and bordering lesions in multiple sclerosis patients and in view of their known pathogenity in lupus nephritis the aim of this project was to further investigate their role in multiple sclerosis. Using the acute experimental allergic encephalomyelitis (EAE) model in the Lewis rat, the inflammatory phase of disease was profiled using immunohistological and ELISA methods and was related to clinical sign severity. The parameters of interest were central nervous system deposits of IgM, IgG, B cells and C3 and anti-DNA antibodies in sera, cerebrospinal fluid and in situ. In situ evaluation of anti-dsDNA antibodies was also performed in tissue taken from Biozzi (AH) mice (relapsing/remitting EAE model) and from a multiple sclerosis patient. Inflammatory deposits specifically at sites of perivascular cuffing were found to increase with increasing clinical sign severity. At the time clinical signs had plateaued in the Lewis rat, intrathecal anti-dsDNA antibodies were at their highest level and anti-ssDNA antibodies at their lowest. The latter possibly due to their involvement in the 'clearing-up' process following tissue damage. Using novel DNA probes fluorescence suggestive of the presence of anti-dsDNA iii antibodies was seen in both animal and human tissue. Within human tissue the antibodies appeared to accumulate around active lesions and within vessels, raising the question of these antibodies having differing location dependent functions. EAE models have the potential to investigate these findings further and to evaluate new therapies.
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Colonnese, Benni Vittoria. "Dante nel cinema dal muto al digitale." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0021/NQ45726.pdf.
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Generali, Daniela. "Dal baratto alla moneta: un approccio simulativo." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amslaurea.unibo.it/3177/.
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Il percorso parte dall'analisi delle strategie della Teoria dei giochi, si sofferma sul concetto di razionalità nelle decisioni(economiche); continua con la descrizione del funzionamento del baratto in tempi antichi e le declinazioni che ha avuto(economie del dono, baratto muto); esamina la teoria del valore di Carl Menger, per poi allargare la visione alle teorie del valore enunciate dagli economisti dal XVIII secolo, anni in cui si iniziavano ad esaminare i meccanismi alla base degli scambi di mercato; si precisa il funzionamento del ciclo economico(non è eterno), la possibilità di crollo del sistema economico, le ripercussioni di questo sulla moneta(ricerca di sistemi economici alternativi). Nella seconda parte si analizzano i risultati delle più recenti simulazioni relative alla nascita della moneta e, non meno importante, al suo collasso.