Relevant bibliographies by topics / DAPL

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Academic literature on the topic 'DAPL'

Author: Grafiati
Published: 4 June 2021
Last updated: 4 February 2022

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Journal articles on the topic "DAPL"

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Hudson, André O., Charles Gilvarg, and Thomas Leustek. "Biochemical and Phylogenetic Characterization of a Novel Diaminopimelate Biosynthesis Pathway in Prokaryotes Identifies a Diverged Form of ll-Diaminopimelate Aminotransferase." Journal of Bacteriology 190, no. 9 (February 29, 2008): 3256–63. http://dx.doi.org/10.1128/jb.01381-07.

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ABSTRACT A variant of the diaminopimelate (DAP)-lysine biosynthesis pathway uses an ll-DAP aminotransferase (DapL, EC 2.6.1.83) to catalyze the direct conversion of l-2,3,4,5-tetrahydrodipicolinate to ll-DAP. Comparative genomic analysis and experimental verification of DapL candidates revealed the existence of two diverged forms of DapL (DapL1 and DapL2). DapL orthologs were identified in eubacteria and archaea. In some species the corresponding dapL gene was found to lie in genomic contiguity with other dap genes, suggestive of a polycistronic structure. The DapL candidate enzymes were found to cluster into two classes sharing approximately 30% amino acid identity. The function of selected enzymes from each class was studied. Both classes were able to functionally complement Escherichia coli dapD and dapE mutants and to catalyze ll-DAP transamination, providing functional evidence for a role in DAP/lysine biosynthesis. In all cases the occurrence of dapL in a species correlated with the absence of genes for dapD and dapE representing the acyl DAP pathway variants, and only in a few cases was dapL coincident with ddh encoding meso-DAP dehydrogenase. The results indicate that the DapL pathway is restricted to specific lineages of eubacteria including the Cyanobacteria, Desulfuromonadales, Firmicutes, Bacteroidetes, Chlamydiae, Spirochaeta, and Chloroflexi and two archaeal groups, the Methanobacteriaceae and Archaeoglobaceae.
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Liu, Yuchen, Robert H. White, and William B. Whitman. "Methanococci Use the Diaminopimelate Aminotransferase (DapL) Pathway for Lysine Biosynthesis." Journal of Bacteriology 192, no. 13 (April 23, 2010): 3304–10. http://dx.doi.org/10.1128/jb.00172-10.

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ABSTRACT The pathway of lysine biosynthesis in the methanococci has not been identified previously. A variant of the diaminopimelic acid (DAP) pathway uses diaminopimelate aminotransferase (DapL) to catalyze the direct conversion of tetrahydrodipicolinate (THDPA) to ll-DAP. Recently, the enzyme DapL (MTH52) was identified in Methanothermobacter thermautotrophicus and shown to belong to the DapL1 group. Although the Methanococcus maripaludis genome lacks a gene that can be unambiguously assigned a DapL function based on sequence similarity, the open reading frame MMP1527 product shares 30% amino acid sequence identity with MTH52. A Δmmp1527 deletion mutant was constructed and found to be a lysine auxotroph, suggesting that this DapL homolog in methanococci is required for lysine biosynthesis. In cell extracts of the M. maripaludis wild-type strain, the specific activity of DapL using ll-DAP and α-ketoglutarate as substrates was 24.3 ± 2.0 nmol min−1 mg of protein−1. The gene encoding the DapL homolog in Methanocaldococcus jannaschii (MJ1391) was cloned and expressed in Escherichia coli, and the protein was purified. The maximum activity of MJ1391 was observed at 70°C and pH 8.0 to 9.0. The apparent Km s of MJ1391 for ll-DAP and α-ketoglutarate were 82.8 ± 10 μM and 0.42 ± 0.02 mM, respectively. MJ1391 was not able to use succinyl-DAP or acetyl-DAP as a substrate. Phylogenetic analyses suggested that two lateral gene transfers occurred in the DapL genes, one from the archaea to the bacteria in the DapL2 group and one from the bacteria to the archaea in the DapL1 group. These results demonstrated that the DapL pathway is present in marine methanogens belonging to the Methanococcales.
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Beucher, Becky. "Memes and Social Messages: Teaching a Critical Literacies Curriculum on DAPL." International Journal of Multicultural Education 22, no. 3 (December 31, 2020): 24. http://dx.doi.org/10.18251/ijme.v22i3.2235.

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This article documents the design and implementation of a culturally responsive critical media literacies curriculum centered around media representations of the Dakota Access Pipeline (DAPL). Students (grades 6-8) were invited to discuss media imagery relating to DAPL and to create memes reflecting their understandings. To situate this work, we articulate a framework that blends critical media literacies and culturally responsive and sustaining pedagogy. We analyze students’ spoken and multimodal responses to a curriculum that purposefully foregrounded Native perspectives and digital media. Ultimately, we argue that students must be invited to leverage their epistemic privilege in responding to contemporary social issues.
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Goeckner, Ryan, Sean M. Daley, Jordyn Gunville, and Christine M. Daley. "Cheyenne River Sioux Traditions and Resistance to the Dakota Access Pipeline." Religion and Society 11, no. 1 (September 1, 2020): 75–91. http://dx.doi.org/10.3167/arrs.2020.110106.

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The No Dakota Access Pipeline resistance movement provides a poignant example of the way in which cultural, spiritual, and oral traditions remain authoritative in the lives of American Indian peoples, specifically the Lakota people. Confronted with restrictions of their religious freedoms and of access to clean drinking water due to construction of the Dakota Access Pipeline (DAPL), members of Lakota communities engaged with traditions specific to their communities to inform and structure the No DAPL resistance movement. A series of interviews conducted on the Cheyenne River Sioux Nation with tribal members reveal that Lakota spiritual traditions have been integral to every aspect of the movement, including the motivations for, organization of, and understanding of the future of the movement.
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Martini, Michele. "Online distant witnessing and live-streaming activism: Emerging differences in the activation of networked publics." New Media & Society 20, no. 11 (April 11, 2018): 4035–55. http://dx.doi.org/10.1177/1461444818766703.

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Since its formal approval, the Dakota Access Pipeline (DAPL) project raised public concern about environmental sustainability and security. Thanks to the systematic use of Internet and communication technologies (ICTs), the nonviolent resistance organized by the Sioux tribes of Standing Rock Reservation to oppose the planned construction rapidly attracted public attention. In view of their strategic use of online video-sharing for documentation and counter-surveillance purposes, this study aims at describing how diverse modes of user activity are triggered by two different forms of distant witnessing: online video and live streaming. To this aim, this study analyzes the user activity which took place on the Digital Smoke Signals Facebook page, one of the most widely followed information outlets of the NO DAPL movement. Findings suggest that online video and live streaming trigger different forms of connective activity. The highlighted differences reflect the ways in which synchronous and asynchronous forms of online audio-visual communication impact users’ everyday life.
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Kieffer, C. L., and Devorah Romanek. "Crowdsourcing a Current Events Exhibition on Community Activism Against DAPL." Curator: The Museum Journal 62, no. 2 (April 2019): 135–50. http://dx.doi.org/10.1111/cura.12302.

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Fuchs, Thilo M., Boris Schneider, Karin Krumbach, Lothar Eggeling, and Roy Gross. "Characterization of a Bordetella pertussisDiaminopimelate (DAP) Biosynthesis Locus Identifies dapC, a Novel Gene Coding for anN-Succinyl-l,l-DAP Aminotransferase." Journal of Bacteriology 182, no. 13 (July 1, 2000): 3626–31. http://dx.doi.org/10.1128/jb.182.13.3626-3631.2000.

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ABSTRACT The functional complementation of two Escherichia colistrains defective in the succinylase pathway ofmeso-diaminopimelate (meso-DAP) biosynthesis with a Bordetella pertussis gene library resulted in the isolation of a putative dap operon containing three open reading frames (ORFs). In line with the successful complementation of the E. coli dapD and dapE mutants, the deduced amino acid sequences of two ORFs revealed significant sequence similarities with the DapD and DapE proteins of E. coli and many other bacteria which exhibit tetrahydrodipicolinate succinylase and N-succinyl-l,l-DAP desuccinylase activity, respectively. The first ORF within the operon showed significant sequence similarities with transaminases and contains the characteristic pyridoxal-5′-phosphate binding motif. Enzymatic studies revealed that this ORF encodes a protein withN-succinyl-l,l-DAP aminotransferase activity converting N-succinyl-2-amino-6-ketopimelate, the product of the succinylase DapD, to N-succinyl-l,l-DAP, the substrate of the desuccinylase DapE. Therefore, this gene appears to encode the DapC protein of B. pertussis. Apart from the pyridoxal-5′-phosphate binding motif, the DapC protein does not show further amino acid sequence similarities with the only other known enzyme with N-succinyl-l,l-DAP aminotransferase activity, ArgD of E. coli.
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White, George W., and Bruce V. Millett. "OIL TRANSPORT AND PROTECTING CLEAN WATER: THE CASE OF THE DAKOTA ACCESS PIPELINE (DAPL)." Present Environment and Sustainable Development 13, no. 2 (October 15, 2019): 115–28. http://dx.doi.org/10.15551/pesd2019132008.

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Oil frequently plays a crucial role in modern industrial economies. It is a very costly natural resource for those countries that do not have it, but very profitable for those that do. Yet, developing oil resources and transporting them to market has its own costs, not only in terms of production but also in terms of impacts on other valuable natural resources such as clean water. Not surprisingly, governments can have strict environmental regulations concerning oil transport. However, such regulations can be complicated, especially in countries like the United States where many different government agencies claim jurisdiction, especially at differing spatial scales. Consequently, conflict can result from competing interests, pitting those developing oil resources against those already using resources such as clean water. This paper explores the complicated geographies of environmental regulations and how competing entities pursue and protect their interests through environmental ligation. In doing so, this study uses the example of the Dakota Access Pipeline (the DAPL) because the conflict surrounding it garnered considerable national and international attention.
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Presley, Rachel, and Jason Crane. "Sonic colonizations, sound coalitions: analyzing the aural landscape of Standing Rock’s No-DAPL movement." Argumentation and Advocacy 54, no. 4 (October 2, 2018): 305–22. http://dx.doi.org/10.1080/10511431.2018.1509595.

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Hudson, André O., Irma Girón, and Renwick C. J. Dobson. "Crystallization and preliminary X-ray diffraction analysis ofL,L-diaminopimelate aminotransferase (DapL) fromChlamydomonas reinhardtii." Acta Crystallographica Section F Structural Biology and Crystallization Communications 67, no. 1 (December 24, 2010): 140–43. http://dx.doi.org/10.1107/s174430911004844x.

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Dissertations / Theses on the topic "DAPL"

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Dew, Robert, and mikewood@deakin edu au. "The development of DAL and DAPL languages for building distributed applications." Deakin University. School of Information Technology, 2002. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20050826.101627.

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A common characteristic among parallel/distributed programming languages is that the one language is used to specify not only the overall organisation of the distributed application, but also the functionality of the application. That is, the connectivity and functionality of processes are specified within a single program. Connectivity and functionality are independent aspects of a distributed application. This thesis shows that these two aspects can be specified separately, therefore allowing application designers to freely concentrate on either aspect in a modular fashion. Two new programming languages have been developed for specifying each aspect. These languages are for loosely coupled distributed applications based on message passing, and have been designed to simplify distributed programming by completely removing all low level interprocess communication. A suite of languages and tools has been designed and developed. It includes the two new languages, parsers, a compilation system to generate intermediate C code that is compiled to binary object modules, a run-time system to create, manage and terminate several distributed applications, and a shell to communicate with the run-tune system. DAL (Distributed Application Language) and DAPL (Distributed Application Process Language) are the new programming languages for the specification and development of process oriented, asynchronous message passing, distributed applications. These two languages have been designed and developed as part of this doctorate in order to specify such distributed applications that execute on a cluster of computers. Both languages are used to specify orthogonal components of an application, on the one hand the organisation of processes that constitute an application, and on the other the interface and functionality of each process. Consequently, these components can be created in a modular fashion, individually and concurrently. The DAL language is used to specify not only the connectivity of all processes within an application, but also a cluster of computers for which the application executes. Furthermore, sub-clusters can be specified for individual processes of an application to constrain a process to a particular group of computers. The second language, DAPL, is used to specify the interface, functionality and data structures of application processes. In addition to these languages, a DAL parser, a DAPL parser, and a compilation system have been designed and developed (in this project). This compilation system takes DAL and DAPL programs to generate object modules based on machine code, one module for each application process. These object modules are used by the Distributed Application System (DAS) to instantiate and manage distributed applications. The DAS system is another new component of this project. The purpose of the DAS system is to create, manage, and terminate many distributed applications of similar and different configurations. The creation procedure incorporates the automatic allocation of processes to remote machines. Application management includes several operations such as deletion, addition, replacement, and movement of processes, and also detection and reaction to faults such as a processor crash. A DAS operator communicates with the DAS system via a textual shell called DASH (Distributed Application SHell). This suite of languages and tools allowed distributed applications of varying connectivity and functionality to be specified quickly and simply at a high level of abstraction. DAL and DAPL programs of several processes may require a few dozen lines to specify as compared to several hundred lines of equivalent C code that is generated by the compilation system. Furthermore, the DAL and DAPL compilation system is successful at generating binary object modules, and the DAS system succeeds in instantiating and managing several distributed applications on a cluster.
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Gaston, Emilia. "Framing a Sacred Fight: Framing Analysis and Collective Identity of the #noDAPL Movement." Thesis, University of North Texas, 2020. https://digital.library.unt.edu/ark:/67531/metadc1703426/.

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The #noDAPL movement was an Indigenous-led environmental social movement occurring between 2015 and 2017, in which the Standing Rock Sioux and other American Indian tribes comprising the Oceti Sakowin garnered support to oppose the 1,172-mile Dakota Access Pipeline. Pipeline opponents agreed that the pipeline's construction posed a threat to the health and safety of tribal members and other residents of the area and that the pipeline's path crossed previously-designated tribal treaty boundaries, compromising tribal sovereignty. In this body of work, I utilize Facebook data from the Sacred Stone Camp Facebook page to locate and identify collective action frames and core framing tasks, adhering to social movement framing theory. Further, I provide insight into the movement's most used collective action frames and how their use enabled to movement to maintain occupation at protest camps along the Missouri River, garner resources from participants and gain international social support. I also draw on concepts of pan-Indianism and supratribalism to discuss indigenous collective identity, as well as concepts like relational values and Indigenous traditional knowledge to better assess the nuances of Indigenous environmental activism and how this movement evoked discussions of modern day settler colonialism.
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Chou, Danielle 1981. "Dahl friction modeling." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/32826.

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Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2004.
Includes bibliographical references (p. 22).
The drive behind improved friction models has been better prediction and control of dynamic systems. The earliest model was of classical Coulomb friction; however, the discontinuity during force reversal of the Coulomb friction model has long been a point of contention since such a discontinuity does not accurately portray the behavior of real systems. Other models have been suggested, but variations of the Dahl solid friction model remain some of the simplest yet most useful. Dahl's original theory proposed that friction behaved as a stress acting upon the quantum mechanical bonds at the interface. Thus, the relationship between frictional force and position would be analogous to a stress-strain curve, complete with hysteresis should there be permanent displacement akin to plastic deformation in materials. This project reviews the variations of Dahl friction models popular in the literature and then demonstrates it both analytically via Matlab and Simulink simulations and experimentally by observing the behavior of a limited angle torque motor.
by Danielle Chou.
S.B.
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Lin, Yao. "Control of DAPK-1 degradation." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4189.

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DAPK-1 is calcium-calmodulin regulated protein kinase involved in multiple cellular pathways including apoptosis, autophagy, cell survival and motility. The cytokine TNF-α has been reported to induce the degradation of DAPK-1. Here I identified the protease cathepsin B as a novel binding partner of DAPK-1 that protects DAPK-1 from TNF-α induced degradation. Using deletion mutants of DAPK-1, I mapped the cathepsin B binding domain on DAPK-1 to amino acids 836-947. Overexpression of this mini-protein DAPK-1(836-947) facilitated degradation of full-length DAPK-1 and apoptosis induced by TNFR-1. Moreover, siRNA mediated knock-down of DAPK-1 enhanced TNF-α induced apoptosis, confirming the role of DAPK-1 as a survival factor in the TNF-α signalling pathway. In addition, a splice variant of DAPK-1, which I have called s-DAPK-1, was discovered. s-DAPK-1 shares part of DAPK-1’s ankyrin repeats region and cytoskeletal binding domain, and possesses an unique tail region, which contains a cleavage site at its first two amino acids. Unlike DAPK-1, s-DAPK-1 does not contribute to apoptosis induced by high level of MEK/ERK signalling, but it does mimic DAPK-1’s function to induce membrane blebbing. The proteolytically processed form of s-DAPK-1 is more active in the induction of membrane blebbing, which may be due to its higher stability compared to that of full-length s-DAPK-1, suggesting that the tail region can control s-DAPK-1 stability and activity. Co-transfection of s-DAPK-1 and DAPK-1 leads to reduction in DAPK-1 expression level, suggesting a role for s-DAPK-1 to regulate DAPK-1 stability. The kinase domain of DAPK-1 is the region required for s-DAPK-1 to promote DAPK-1 degradation. Surprisingly, s-DAPK-1 does not bind directly to DAPK-1, suggesting that the interaction is indirect and mediated by as yet unidentified accessory proteins. Finally, the experiments with proteasome and lysosome inhibitors indicated that s-DAPK-1 induces DAPK-1 degradation via both lysosome and proteasome pathways.
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Terwilliger, Miranda Lilian Naeser. "Population and habitat analyses for Dall's sheep (Ovis dalli) in Wrangell-St. Elias National Park and Preserve." PURL, 2005. http://www.arlis.org/docs/vol1/71013833.pdf.

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Flynn, Patrick G. "Activation of Non-Muscle Myosin IIB Helps Mediate TNF-Alpha Cell Death Signaling." Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_dissertations/369.

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TNF-alpha can stimulate a variety of kinases with the ability to activate non-muscle myosin II. As a result, increases in actin filament formation and actomyosin contractility (AMC) have been reported in response to TNF-alpha. These events are thought to play an important role in mediating TNF-alpha induced apoptosis but how they do so is unclear. In this study we prevented non-muscle myosin II activation in response to TNF-alpha by treating cells with the myosin light chain kinase (MLCK) inhibitor ML-7 or through isoform specific siRNA knockdown of myosin IIA and IIB. We found that treatment with ML-7 or knockdown of myosin IIB, but not IIA, impaired the cleavage of caspase 3 and caspase 8 as well as nuclear condensation in response to TNF-alpha. During this cell death process myosin II seemed to function independent of AMC since treatment of cells with blebbistatin or cytochalasin D failed to inhibit TNF-alpha induced caspase cleavage. Immunoprecipitation studies revealed associations of myosin IIB with clathrin and FADD in response to TNF-alpha suggesting a role for myosin IIB in TNFR1 endocytosis and DISC formation. Taken together these findings suggest that myosin IIB activation promotes TNF-alpha cell death signaling in a manner independent of its force generating property.
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Punzet, Robert. "99mTc-HYNIC-DAPI-DNA-Bindungsnachweis und Nachweis von DNA-Doppelstrangbrüchen durch 99mTc-HYNIC-DAPI mittels Agarose-Gelelektrophorese." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-146456.

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Hintergrund: Ein sehr häufig in der nuklearmedizinischen Diagnostik genutztes Radionuklid ist 99mTc. Es emittiert Gammastrahlung mit einer relativ niedrigen Energie (140 keV) und hat eine kurze Halbwertszeit von 6 h. Zusätzlich zur Gammastrahlung entstehen bei jedem Zerfall von 99mTc Auger-Elektronen. Diese niederenergetischen Elektronen, sehr kurzer Reichweite verfügen über einen hohen LET und erzeugen somit eine ausreichende Energiedeposition, um direkte DSB zu erzeugen. Bei Untersuchungen zu Chemotoxizität und Radiotoxizität mit Zellexperimenten gilt es eine Vielzahl an verschiedenen Schutzmechanismen, Reparaturmechanismen und Signalkaskaden in Zellen zu beachten, welche häufig noch nicht vollständig erforscht sind. Um das schädigende Potential von unterschiedlichen Substanzen und Strahlenqualitäten auf die DNA zu untersuchen, wurde ein zellfreies System gewählt. Ziel dieser Arbeit war es, neben den Strahlenqualitäten der Alpha-, Beta, Gamma- und Röntgenstrahlung die Auger-Elektronen des 99mTc auf ihr Potential zur Induktion von DNA-Strangbrüchen zu untersuchen. Hierfür stand die Substanz 99mTc-HYNIC-DAPI zur Verfügung, welche 99mTc an das Plasmid binden und somit in direkte DNA-Nähe bringen kann. Material und Methode: Alle Versuche wurden mit dem Plasmid pUC 19, einem künstlich hergestellten, bakteriellen Plasmid mit 2686 Basenpaaren, welches als nackte DNA ohne Proteine vorliegt, durchgeführt. Der Vergleich zwischen bestrahltem Plasmid in Ab- und Anwesenheit des Radikalfängers DMSO gibt Hinweise darauf, ob Strangbrüche direkt induziert oder nach Radikalbildung indirekt erzeugt werden. Bei radikalvermittelter Wirkung verhindert DMSO DNA-Strangbrüche und die ungeschädigte Supercoiled-Plasmid-Konformation bleibt erhalten. Nach Bestrahlung des Plasmids erfolgte der Nachweis von Strangbrüchen mittels Agarose-Gelelektrophorese. Bekommt ein Plasmid Einzel- oder Doppelstrangbrüche, so verändert sich seine Konformation zu einem ringförmigen/open circle (ESB) oder einem linearen Plasmid (DSB). Durch veränderte Laufeigenschaften im Agarosegel sind die verschiedenen Konformationen voneinander trennbar. Nach Anfärben der DNA mit dem Fluoreszenzfarbstoff Ethidiumbromid konnte das fluoreszierende Plasmid fotografiert und die Intensität der Konformationsbanden quantifiziert werden. Ergebnisse: Zuerst wurde die Reproduzierbarkeit der Methodik überprüft und festgestellt, dass eine Korrelation zwischen Plasmidmasse und Fluoreszenzintensität besteht. Anschließend wurde in Vorversuchen gezeigt, dass die Inkubationstemperaturen, pH-Werte und der Radikalfänger DMSO keinen Einfluss auf die Plasmidintegrität haben. Bei Bestrahlung mit Röntgenstrahlung, dem Beta-Strahler 188Re und dem nicht DNA-gebundenen Gamma-Strahler und Auger-Emitter 99mTc konnte mit steigender Dosis eine Zunahme an ESB festgestellt werden. Vergleichsproben mit DMSO zeigten keinen Anstieg von ESB, was auf eine radikalvermittelte 67 DNA-Schädigung mittels Reaktiver Sauerstoffspezies (ROS) hinweist. Ab einer Energiedosis von ca. 80 Gy konnten nach Bestrahlung mit 188Re und 99mTc zusätzlich zu den ESB auch DSB nachgewiesen werden. DMSO konnte in den Vergleichsproben sowohl die ESB als auch die DSB erfolgreich verhindern. Bei einer sehr hohen Dosis ≥ 600 Gy zeigte DMSO Kapazitätsgrenzen und es konnten nicht mehr alle Strangbrüche verhindert werden. Die Bestrahlung mit dem Alpha-Strahler (hoher LET) 223Ra fügte, im Vergleich zu Strahlung mit niedrigem LET, dem Plasmid überproportional viele DSB zu. Einige dieser DSB konnten nicht durch DMSO verhindert werden, was auf einen direkten DNA-Schaden bzw. eine zu hohe Radikaldichte hinweist. Ein noch stärkerer direkter Effekt konnte beobachtet werden, wenn 99mTc über die Substanz 99mTc-HYNIC-DAPI an DNA gebunden wurde. Dabei konnten schon ab einer Energiedosis von 4 Gy DSB erzeugt werden, welche trotz Radikalfänger nicht verhindert werden konnten. Schlussfolgerung: Dieser bei 99mTc-HYNIC-DAPI beobachtete Effekt wird den Auger-Elektronen zugeschrieben. Aufgrund ihrer kurzen Reichweite und ihres hohen LET sind sie in der Lage direkte DSB zu erzeugen, wenn sie DNA-gebunden sind oder sich in geringem Abstand zur DNA befinden. Die Ergebnisse der Experimente weisen auf ein therapeutisches Potential von 99mTc hin. Weitere Untersuchungen müssen zeigen, ob eine Adressierung von 99mTc an die DNA im Zellkern einer intakten Zelle zu verwirklichen ist und ob DNA-gebundenes 99mTc durch die Energie der Auger-Elektronen den Zelltod herbeiführen kann. Im nächsten Schritt sollte die Erforschung von Trägersubstanzen erfolgen, welche es ermöglichen Auger-Emitter spezifisch an die DNA von Tumorzellen zu koppeln
Introduction and aim of the study: A radionuclide commonly used in diagnostic nuclear medicine is 99mTc. It emits gamma rays with a relatively low energy (140 keV) and has a short half-time (6h). In addition to gamma rays, 99mTc radiates so called Auger-electrons with low energy, low range and high linear energy transfer. Due to the high-LET Auger-electrons have a sufficient energy deposition to induce direct double-strand breaks to the DNA. In these experiments we used plasmid DNA to evaluate damage induced to biological systems by different chemotoxical substances and radionuclides as well as external radiation. By using plasmids instead of cell cultures we avoid lots of unexplored signal pathways in cells and it is possible to quantify chemotoxical and radiation damage to the DNA. Materials and methods: The double-stranded plasmid pUC 19 with 2686 bp is used in all experiments. It is a synthetically produced bacterial plasmid without any proteins. To distinguish between directly and indirectly (radical induced) induced damage we used the radical scavenger DMSO. Indirectly induced damage via reactive oxygen species (ROS) can be prevented by DMSO. The quantification of supercoiled forms, single strand breaks (SSB) and double strand breaks (DSB) was measured by the method of agarose gel electrophoresis. After the electrophoresis, agarose gels are dyed in ethidium bromide and imaged with a ccd-camera using ultraviolet transillumination. The bands of the different plasmid forms were quantified through the FIJI computer program. Results: First of all a correlation between plasmid mass and fluorescence intensity was shown. In a pretrial no damaging effect to the plasmid from incubation temperature, pH-value and radical scavenger DMSO appeared. Afterwards we examined chemotoxical SnCl2, external x-rays, the alpha emitter 223Ra, the beta emitter 188Re, gamma- and Auger-emitter 99mTc and the DNA-bound 99mTc-HYNIC-DAPI. The radical scavenger DMSO was used to differentiate between indirect (radical induced) and direct DNA-damage. All different radiation qualities showed an increasing DNA-damage with increasing energy dose. For the low-LET radiation qualities like chemotoxical SnCl2, external x-rays, the beta emitter 188Re and not DNA-bound 99mTc, DMSO showed the quality to prevent the damage. After the deposition of an energy dose ≥ 600 Gy DMSO showed a limitation in his scavenger capacity. During radiation with high-LET beams like 223Ra or DNA-bound 99mTc-HYNIC-DAPI DMSO showed less or nearly no ability to prevent DNA-damage. A 4 Gy dose of 99mTc-HYNIC-DAPI was able to induce DSB into the plasmid. These DSB could not be prevented by DMSO. The lower ESB:DSB ratio for high-LET beams also displays that direct damage is more likely to create DSB than indirect damage. Conclusion: In conclusion we can say that DNA-bound 99mTc-HYNIC-DAPI was most appropriate to induce DSB via a direct effect. It was impossible to prevent this damage due to adding the 69 radical scavenger DMSO. We attribute this to low range, low-LET Auger-electrons and suppose that it may be possible to use DNA-bound 99mTc for therapeutic purpose. Further research has to show if 99mTc can be targeted to the DNA of intact cells and if suitable tracers can be found to safely target and kill tumor cells
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Smith, Joel W. S. "Investigating the mechanism of translational stimulation by Deleted in Azoospermia-like." Thesis, University of Edinburgh, 2008. http://hdl.handle.net/1842/4849.

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The proper expression of a gene to a protein is a complicated process with many steps. One of the major steps is translation, the process of decoding a messenger RNA signal and the building of a protein from its component parts. The control of translation is one of the major steps for the overall control of gene expression and its dysregulation is associated with a wide variety of human diseases including neurological, metabolic and reproductive disorders. Dazl family proteins are germ cell restricted RNA binding proteins that contain a motif characteristic of this family, the DAZ domain. Whilst humans encode all three family members DAZ, DAZL and BOULE, flies only possess the boule gene. The members of this family have an essential conserved role in gametogenesis in a wide variety of organisms from worm to man with loss of function resulting in phenotypes ranging from male or female infertility or both. However, little is known about the molecular role of these proteins in germ cell development. A previous study within the laboratory showed that several vertebrate Dazl family members can stimulate translation of a reporter gene in Xenopus laevis oocytes, suggesting a conserved role in mRNA specific translational control. This is consistent with studies in invertebrates. It was proposed that Dazl proteins fulfil this function through an interaction with a translation initiation factor, poly(A) binding protein, PABP. The aim of this thesis was to further refine this model of action. The work presented here investigates several fundamental questions regarding the mechanism of Dazl-mediated stimulation. First, it investigated the step of translation initiation that Dazl acts upon and explored the initiation factors that may be required. Second, it addressed in more detail the requirements for an interaction between Dazl and the poly(A) binding protein, PABP. Third, it examined the potential role of another factor, DAZ associated protein 1, DAZAP1, in Dazl-mediated stimulation. The role of multi-protein complexes containing Dazl bound to the 3’UTR that localise, repress and stimulate translation of specific mRNAs at defined times during gametogenesis are discussed.
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Carnino, Cecilia. "Dal lusso al consumo." Paris 1, 2012. http://www.theses.fr/2012PA010602.

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La thèse présente a pour objet de reconstruire les implications intellectuelles de la réflexion sur le luxe et sur la consommation qui fut effectuée dans l'Italie de la seconde moitié du dix-huitième siècle, et ce notamment durant le passage de l'ancien régime à la période révolutionnaire. Il s'agit ici de mettre en évidence l'importance que cette réflexion assuma en Italie durant la seconde moitié du dix-huitième siècle, tant du point de vue économique que politique. Notre recherche met notamment en lumière la forte dimension politique que la réflexion économique sur le luxe et la consommation revêtit à cette époque en Italie. Elle a permis en effet de véhiculer une critique radicale du système hiérarchique de l'ancien régime et de proposer un nouveau modèle de société fondé sur des bases plus égalitaires et capables d'harmoniser intérêts privés, justice sociale et prospérité publique. Ce travail a permis également de voire la culture politique italienne durant le passage de l'ancien régime à la phase révolutionnaire. La réflexion sur le luxe et la consommation permet de comprendre combien les patriotes ont adhéré amplement aux principes du libéralisme économique: ils avaient en effet la conviction que c'était précisément sur ce terrain que l'on pourrait conserver les transformations sociales réalisées grâce à la chute de l'ancien régime. Suivant le sillon de la réflexion économique qui avait caractérisé l'Italie à partir des années 1760, mais en même temps pleinement conscients de la nécessité d'une fracture politique radicale, les patriotes ont misé sur la garantie de l'égalité des opportunités. Ceci constituait à la fois un moyen privilégié pour assurer prospérité publique et amélioration générale du bien-être matériel, ainsi qu'un instrument visant à l'égalité des conditions sociales.
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Edwards, Jennifer Somerville 1967. "Louise Dahl-Wolfe: A fashion photographer redefined." Thesis, The University of Arizona, 1996. http://hdl.handle.net/10150/291450.

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Dahl-Wolfe (1895-1989) is best-known as a fashion photographer, her photographic life encompassed a pattern of art and documentary ideas interwoven over a forty-year period. This thesis describes her early art influences and explores her photography career in regards to the historical and cultural developments from World War I through the 1950s. Dahl-Wolfe is compared with her contemporaries such as Consuelo Kanaga, Dorothea Lange, Edward Weston, Richard Avedon, and Henri Cartier-Bresson. The study reveals how Dahl-Wolfe's work reflects photography's evolution over a specific period and how traditional constructions affect the reception of commercial photographers. Conclusively, Dahl-Wolfe's oeuvre straddles such an array of constructed arenas that she virtually fell through the cracks and has been narrowly defined as a result of art historical definitions.
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Books on the topic "DAPL"

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Whitten, Kenneth R. Estimating population size and composition of dall sheep in Alaska: Assessment of previously used methods and experimental implementation of new techniques. [Juneau, AK]: Alaska Department of Fish and Game, Division of Wildlife Conservation, 1997.

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Dall'Antonia, Emilio. Cappella Maggiore: Cronache dall'8 settembre '43 alla liberazione : dal diario di Emilio Dall'Antonia. Vittorio Veneto, Italy]: Dario De Bastiani editore, 2013.

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Durtsche, Bruce M. Distribution, movements and seasonal use areas of radio-collared Dall sheep in the White Mountains - Tanana Hills, Alaska, 1983-1989. Anchorage, Alaska: Bureau of Land Management, Alaska State Office, 1990.

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Heimer, Wayne E. Publication of Dall sheep findings and development of future research direction. Juneau, AK: Alaska Dept. of Fish and Game, Division of Game, 1987.

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Russ, Tony. Sheep hunting in Alaska: The Dall sheep hunter's guide. Wasilla, AK: Northern Pub., 1994.

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Dāl dalyah. Lāhaur: Sang-i Mīl Pablīkeshanz, 1997.

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Azi, Assad. Dape zehut. Ramat Gan: Muzeʾon le-omanut Yiśreʾelit, 1988.

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Stephen, Gulbis, ed. Roald Dahl. Harmondsworth: Puffin, 1985.

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Bingham, Jane. Roald Dahl. Chicago: Raintree, 2010.

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West, Mark I. Roald Dahl. New York: Twayne, 1992.

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Book chapters on the topic "DAPL"

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Lukas, Thomas J., Daniela V. Rosa, Luiz Alexandre V. Magno, Bruno R. Souza, Marco A. Romano-Silva, Hisao Masai, Kazuhisa Kohda, et al. "DAPK." In Encyclopedia of Signaling Molecules, 502. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_100337.

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Butler, Catherine. "Introduction." In Roald Dahl, 1–13. London: Macmillan Education UK, 2012. http://dx.doi.org/10.1007/978-1-137-28504-1_1.

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Scott, Carole. "Roald Dahl and Quentin Blake." In Roald Dahl, 160–75. London: Macmillan Education UK, 2012. http://dx.doi.org/10.1007/978-1-137-28504-1_10.

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Hunt, Peter. "Roald Dahl and the Commodification of Fantasy." In Roald Dahl, 176–89. London: Macmillan Education UK, 2012. http://dx.doi.org/10.1007/978-1-137-28504-1_11.

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Thacker, Deborah Cogan. "Fairy Tale and Anti-Fairy Tale: Roald Dahl and the Telling Power of Stories." In Roald Dahl, 14–30. London: Macmillan Education UK, 2012. http://dx.doi.org/10.1007/978-1-137-28504-1_2.

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Stallcup, Jackie E. "Discomfort and Delight: The Role of Humour in Roald Dahl’s Works for Children." In Roald Dahl, 31–50. London: Macmillan Education UK, 2012. http://dx.doi.org/10.1007/978-1-137-28504-1_3.

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Rudd, David. "‘Don’t gobbelfunk around with words’: Roald Dahl and Language." In Roald Dahl, 51–69. London: Macmillan Education UK, 2012. http://dx.doi.org/10.1007/978-1-137-28504-1_4.

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Pinsent, Pat. "‘The problem of school’: Roald Dahl and Education." In Roald Dahl, 70–85. London: Macmillan Education UK, 2012. http://dx.doi.org/10.1007/978-1-137-28504-1_5.

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Alston, Ann. "The Unlikely Family Romance in Roald Dahl’s Children’s Fiction." In Roald Dahl, 86–101. London: Macmillan Education UK, 2012. http://dx.doi.org/10.1007/978-1-137-28504-1_6.

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Pennell, Beverley. "‘When one is with her it is impossible to be bored’: An Examination of Roald Dahl’s Contribution to a Feminist Project in Children’s Literature." In Roald Dahl, 102–22. London: Macmillan Education UK, 2012. http://dx.doi.org/10.1007/978-1-137-28504-1_7.

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Conference papers on the topic "DAPL"

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Hlaváček, Jan, Jan Pícha, Václav Vaněk, Jiří Jiráček, Jiřina Slaninová, Vladimír Fučík, Danuta Gilner, and Richard C. Holc. "Analogues of Orn and DAP as potential inhibitors of bacterial enzymes ArgE and DapE." In XIth Conference Biologically Active Peptides. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2009. http://dx.doi.org/10.1135/css200911043.

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Chen, Chien-Chih, Yin-Chi Peng, Cheng-Fen Chen, Wei-Shan Wu, Qinghao Min, Pen-Chung Yew, Weihua Zhang, and Tien-Fu Chen. "DAPs." In the The 51st Annual Design Automation Conference. New York, New York, USA: ACM Press, 2014. http://dx.doi.org/10.1145/2593069.2593116.

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Fan, Yixing, Qingyao Ai, Zhaochun Ren, Liangjie Hong, Dawei Yin, and Jiafeng Guo. "DAPA." In WSDM '19: The Twelfth ACM International Conference on Web Search and Data Mining. New York, NY, USA: ACM, 2019. http://dx.doi.org/10.1145/3289600.3291375.

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Mogi, Katsuo, Yasuhiko Sugii, Teruo Fujii, and Yoichiro Matsumoto. "A Microfluidic Culturing System for Observation of Free-Floating Microorganisms." In ASME 2013 11th International Conference on Nanochannels, Microchannels, and Minichannels. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/icnmm2013-73164.

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We observed the effect of the ethanol toxicity on individual cells of Botryococcus braunii (B. braunii) in microchannel environment. For continuous observation of B. braunii in microchannel environment, a microfluidic device which has a specific channel structure was developed. By using the channel structure, microorganisms were sorted by their size and captured on the corresponding area in the channel. In the experiment, suspension of B. braunii with DAPI was injected into the device for the cell capturing in the experiment. Following the cell capturing, ethanol with DAPI 0.5% was injected into the channel for 60 minutes. Damaged cells were confirmed by their deformation and the fluorescence of DAPI. The strong fluorescence of DAPI was confirmed after 20 minutes. On the other hand, the fluorescence of the chloroplast became weak in contrast to the fluorescence of DAPI. We successfully confirmed the time condition of exposing B. braunii to ethanol in the micro channel.
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Li, Tao, Wubai Zhou, Chunqiu Zeng, Qing Wang, Qifeng Zhou, Dingding Wang, Jia Xu, et al. "DI-DAP." In CIKM'16: ACM Conference on Information and Knowledge Management. New York, NY, USA: ACM, 2016. http://dx.doi.org/10.1145/2983323.2983355.

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Sapna, Sapna, NS Sreenivasalu, and Kolin Paul. "DAPP: Accelerating Training of DNN." In 2018 IEEE 20th International Conference on High Performance Computing and Communications; IEEE 16th International Conference on Smart City; IEEE 4th International Conference on Data Science and Systems (HPCC/SmartCity/DSS). IEEE, 2018. http://dx.doi.org/10.1109/hpcc/smartcity/dss.2018.00144.

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Ghaemi Osgouie, Kambiz, Ali Meghdari, Saeed Sohrabpour, and Mehdi Salmani Jelodar. "Optimal Configuration of a 4-DOF Dual-Arm Cam-Lock Manipulator." In ASME 2007 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/detc2007-35026.

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The Dual-Arm Cam-Lock (DACL) robot manipulators are reconfigurable arms formed by two parallel cooperative manipulators. Some of their joints may lock into each other. Therefore, the arms normally operate redundantly. However, when higher structural stiffness is needed these two arms can lock into each other in specific joints and loose some degrees of freedom. In this paper, the dynamics of the DACL robot is discussed and parametrically formulated. On the other hand, the criteria and implementation of genetic algorithm (GA) to optimize the configuration of DACL robot manipulators at a specific point with the objective to maximize the cooperatively applicable task-space force in a desired direction are addressed. To obtain a more efficient process, an initial population is generated satisfying the geometrical constraints of the planar arms.
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Chen, Yu-Chi, Song-Yi Hsu, Ting-Wei Chang, and Ting-Wei Wu. "Lottery DApp from Multi-Randomness Extraction." In 2019 IEEE International Conference on Blockchain and Cryptocurrency (ICBC). IEEE, 2019. http://dx.doi.org/10.1109/bloc.2019.8751323.

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Chen Zhou, Liang-Tien Chia, and Bu-Sung Lee. "DAML-QoS ontology for Web services." In Proceedings. IEEE International Conference on Web Services, 2004. IEEE, 2004. http://dx.doi.org/10.1109/icws.2004.1314772.

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Parkinson, D., D. J. Hunt, and K. S. MacQueen. "The AMT DAP 500." In COMPCON Spring 88. IEEE, 1988. http://dx.doi.org/10.1109/cmpcon.1988.4858.

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Reports on the topic "DAPL"

1

Martin, David L., Grit Denker, Richard Waldinger, and Jerry Hobbs. Knowledge Creation Tools for DAML. Fort Belvoir, VA: Defense Technical Information Center, March 2006. http://dx.doi.org/10.21236/ada449078.

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Anyiwo, David E. Building the DAML Electronic Commerce Domain. Fort Belvoir, VA: Defense Technical Information Center, February 2002. http://dx.doi.org/10.21236/ada417128.

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Anyiwo, David E. Building the DAML Electronic Commerce Domain. Fort Belvoir, VA: Defense Technical Information Center, November 2001. http://dx.doi.org/10.21236/ada417129.

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Anyiwo, David E. Building the DAML Electronic Commerce Domain. Fort Belvoir, VA: Defense Technical Information Center, August 2001. http://dx.doi.org/10.21236/ada417130.

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Anyiwo, David E. Building the DAML Electronic Commerce Domain. Fort Belvoir, VA: Defense Technical Information Center, July 2002. http://dx.doi.org/10.21236/ada417127.

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Zakharov, V. N., K. G. Tarasov, N. I. Sobolev, L. V. Alekseeva, K. V. Sizyukhina, E. N. Vyal', and O. A. Sosnovskaya. Concordances of works of V. I. Dahl. Science and Innovation Center Publishing House, 2014. http://dx.doi.org/10.12731/ofernio.2014.20632.

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Wu, Dan, Bijan Parsia, Evren Sirin, James Hendler, and Dana Nau. Automating DAML-S Web Services Composition Using SHOP2. Fort Belvoir, VA: Defense Technical Information Center, January 2006. http://dx.doi.org/10.21236/ada447972.

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Weirick, L. J. Shock characterization of Diallyl Phthalate (DAP). Office of Scientific and Technical Information (OSTI), September 1992. http://dx.doi.org/10.2172/6957402.

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Cost, R. S., Tim Finin, Anupam Joshi, Yun Peng, Charles Nicholas, Ian Soboroff, Harry Chen, Lalana Kagal, Filip Perich, and Youyong Zou. ITTALKS: A Case Study in the Semantic Web and DAML. Fort Belvoir, VA: Defense Technical Information Center, January 2005. http://dx.doi.org/10.21236/ada439603.

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Jarvis, John J., and H. D. Ratliff. Evaluation of the USTRANSCOM Deployment Analysis Prototype (DAP). Fort Belvoir, VA: Defense Technical Information Center, September 1988. http://dx.doi.org/10.21236/ada200725.

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