Academic literature on the topic 'Da xin wei yuan hui'

The article is devoted to the study of the Song of the Great Dao of the Spiritualized Source (Ling yuan da dao ge). This is a work on Daoist “inner alchemy”, which describes the process of transforming the spirit and the breath in poetic form. The author of Ling yuan da dao ge was the Daoist nun and poetess Cao Wen-yi (1039–1115). Cao Wen-yi is the only woman-philosopher who wrote a commentary on the Dao De jing, which has survived to this day in the Daoist Canon (Dao zang). Her talents were highly appreciated by Emperor Huizong, who granted her the title “Excellent in Literary Talent” (Wen-yi zhen-ren). The goal of the study is to highlight the most important ideological and theoretical components of the Song of the Great Dao of the Spiritualized Source. As a result of the study, the cultural and historical environment of this work was reconstructed, its earlier list written in prose was identified, the dating of the full version of Ling yuan da dao ge was clarified, and its content features were revealed. The main task of the Song of the Great Dao of the Spiritualized Source is to explain the principle of simultaneous improvement of inner nature and vitality (xing ming shuang xiu). This principle became the main vector of development of Daoist psychophysiological methods, starting from the Song era. Improving the inner nature, according to Cao Wen-yi, is achieved by detaching the heart from feelings and desires. This state is called “no heart” (wu xin) and is the “true heart of the Dao”. Improving vitality is achieved through breathing exercises, which should be based on the principles of suchness (zi ran) and non-action (wu wei).

Abstract T-cell exhaustion is defined as T-cell dysfunction leading to loss of effector T-cells function. Restoring exhausted T-cells with agonistic anti-4-1BB monoclonal antibody is a promising strategy for cancer treatment. Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) is a classical target with specific expression profiles in tumors. It has limited expression in normal adult tissues, but is overexpressed in multiple types of cancer, especially in colorectal carcinoma and non-small cell lung cancer. Here, we reported a novel bispecific antibody, LM-24C5 that specifically activates 4-1BB in a CEACAM5-dependent manner with localized T cell activation and reduced systemic toxicity. LM-24C5 was developed by introducing qualified 4-1BB heavy-chain variable into a human IgG1 CEACAM5 monoclonal antibody with disabled FcgR-mediated function. LM-24C5 was evaluated for its binding activity to human CEACAM5 and 4-1BB through protein and cell-based assays. The binding activity of LM-24C5 to tumor cells endogenously expressing CEACAM5 and activated primary T cells was confirmed. LM-24C5 was further evaluated in 4-1BB signalling reporter and co-culture assay with human peripheral blood mononuclear cells (PBMC). In vivo anti-tumor activity of LM-24C5 was assessed in hu4-1BB knock-in mice implanted with colon cancer cell line MC38 overexpressing huCEACAM5. Percentage of tumor infiltrating T cells and central memory CD8+ T cells were evaluated by FACS analysis. In addition, 2-week repeated dose toxicity study of LM-24C5 was conducted in hu4-1BB/4-1BBL double-transgenic mice. LM-24C5 efficiently bound to huCEACAM5-postitive cells (EC50: 3.78 nM) and activated human primary T cells. It induced superior 4-1BB activity (EC50: 1.07 nM) than benchmark antibody Urelumab (EC50: 3.38 nM) in the presence of cells expressing CEACAM5. The strength of 4-1BB activation induced by LM-24C5 was correlated with CEACAM5 expression levels. LM-24C5 was also found to stimulate T-cell activation (CD4+ EC50: 0.471, CD8+: 0.482) in PBMCs in a CEACAM5-dependent manner leading to significant IFN-γ production. Injection of LM-24C5 led to complete tumor regression around one month post treatment. Moreover, the tumor-free mice were resistant to tumor rechallenge, suggesting that LM-24C5 can induce long-term protective immunological memory. We have also observed that LM-24C5 increased tumor infiltrating lymphocytes and percentage of central memory CD8+ T cells in spleens. LM-24C5 was well tolerated in hu4-1BB/4-1BBL double-transgenic mice at a dose of 100mg/kg given once weekly for 2 weeks. In summary, LM-24C5 is a novel CEACAM5 dependent 4-1BB bispecific agonist antibody that could redirect and activate T cells to CEACAM5 positive tumor cells by engaging 4-1BB antigen, thus positioned as a potential novel therapy for colorectal carcinoma and other CEACAM5 positive tumors. Citation Format: Wei Cao, Jianjian Liu, Wentao Huang, Junwei Yang, Lei Shi, Yuan Li, Te Du, Xia Qin, Da Fei, Runsheng Li. Pre-clinical efficacy and toxicity profile of LM-24C5: A novel CEACAM5 x 4-1BB bispecific antibody in cancer immunotherapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 2650.

The purpose of the article is to study the presentation of traditional Chinese music genres in the world. The methodology of the study is to use historical and biographical methods in the study of this topic. The scientific novelty of the article is to explore the expediency of presenting traditional Chinese music genres in the world. After all, this question reflects both the traditions and customs of the country and raises the names of scholars of Chinese culture. The presentation of Chinese art is due to the holding of opera festivals that influence the culture of the whole country. The emergence of new theatrical acts and performances also influenced China's outlook. Conclusions. The introduction of traditional Chinese music genres in the world is due to the development of culture and education in the country. The system of thinking of Chinese culture is based on the ancient philosophy of the country. Musical art is in constant search: the nature of sound, timbre palette, forms, combining national motives. Through the combination of national traits, country philosophy, religious tendencies, elements of vocal and instrumental folklore, theater and composition, and piano culture, China's musical piano culture has become well-known in the world. It was the Suetan School and Yuege's educational system that formed the basis for the development of Chinese musical culture. Speaking about the nature of Chinese music, it should be emphasized that it has its intonation-melodic nature, which is different from European music samples. Chinese people became acquainted with the performance of European works through touring. In the early ’70s began to reform the conservatories into musical institutes. For example, music institutions such as the conservatories in Wuhan (Hubei), Shenyang (Liaoning), Xi'an (Shaanxi), and Chengdu (Sichuan) have undergone these changes. During this period (the ’70s), the flowering of Chinese music education began, orchestras, amateur bands appeared, research aroused curiosity, and music magazines began to be published. Teachers such as Zhou Xiaoyan, Lan Yushu, Yu Yixuan, Shen Xiang, Xi Ggui, Wen Quecheng, Li Zhishui, Wei Chixian, Man Jiangxi, Sung Xin, Hu Yan, Gao Zhilan, Do Shinji, and others start their creative activity. The revitalization of music education is in the twentieth century, which causes the development and rethinking of new turns in educational processes. The processes of formation and development of the Chinese music education system are reflected in the works of Wang Yuhe, Liu Pei, Yang Bohua, stylistic features of musical art were interested in F. Arzamanov, V. Vakulishin, Lin Hai, Liu Da-jung, Ma Gesun, Sun Tsunin, In Gen- Ira, Chang Ling, Yang Xiao Xu and more. Chinese education has interested such scholars as: Ding Yun, Yang Bohua. It should be said that much attention was paid to education, as evidenced by the work of scientists. Turning to the historical facts, it becomes known that music education began to develop during the Tang era (VII-X centuries). This led to the emergence of performing schools and the establishment of educational institutions, which allowed to expand the representation of traditional genres of the world.

Graphene-based composites have received a great deal of attention in recent year because the presence of graphene can enhance the conductivity, strength of bulk materials and help create composites with superior qualities. Moreover, the incorporation of metal oxide nanoparticles such as Fe3O4 can improve the catalytic efficiency of composite material. In this work, we have synthesized a composite material with the combination of reduced graphene oxide (rGO), and Fe3O4 modified tissue-paper (mGO-PP) via a simple hydrothermal method, which improved the removal efficiency of the of methylene blue (MB) in water. MB blue is used as the model of contaminant to evaluate the catalytic efficiency of synthesized material by using a Fenton-like reaction. The obtained materials were characterized by SEM, XRD. The removal of materials with methylene blue is investigated by UV-VIS spectroscopy, and the result shows that mGO-PP composite is the potential composite for the color removed which has the removal efficiency reaching 65% in acetate buffer pH = 3 with the optimal time is 7 h. Keywords Graphene-based composite, methylene blue, Fenton-like reaction. References [1] Ma Joshi, Rue Bansal, Reng Purwar, Colour removal from textile effluents, Indian Journal of Fibre & Textile Research, 29 (2004) 239-259 http://nopr.niscair.res.in/handle/123456789/24631.[2] Kannan Nagar, Sundaram Mariappan, Kinetics and mechanism of removal of methylene blue by adsorption on various carbons-a comparative study, Dyes and pigments, 51 (2001) 25-40 https://doi.org/10.1016/S0143-7208(01)00056-0.[3] K Rastogi, J. N Sahu, B. C Meikap, M. N Biswas, Removal of methylene blue from wastewater using fly ash as an adsorbent by hydrocyclone, Journal of hazardous materials, 158 (2008) 531-540.https://doi.org/10.1016/j.jhazmat.2008.01. 105.[4] Qin Qingdong, Ma Jun, Liu Ke, Adsorption of anionic dyes on ammonium-functionalized MCM-41, Journal of Hazardous Materials, 162 (2009) 133-139 https://doi.org/10.1016/j.jhazmat. 2008.05.016.[5] Mui Muruganandham, Rps Suri, Sh Jafari, Mao Sillanpää, Lee Gang-Juan, Jaj Wu, Muo Swaminathan, Recent developments in homogeneous advanced oxidation processes for water and wastewater treatment, International Journal of Photoenergy, 2014 (2014). http://dx. doi.org/10.1155/2014/821674.[6] Herney Ramirez, Vicente Miguel , Madeira Luis Heterogeneous photo-Fenton oxidation with pillared clay-based catalysts for wastewater treatment: a review, Applied Catalysis B: Environmental, 98 (2010) 10-26 https://doi.org/ 10.1016/j.apcatb.2010.05.004.[7] Guo Rong, Jiao Tifeng, Li Ruifei, Chen Yan, Guo Wanchun, Zhang Lexin, Zhou Jingxin, Zhang Qingrui, Peng Qiuming, Sandwiched Fe3O4/carboxylate graphene oxide nanostructures constructed by layer-by-layer assembly for highly efficient and magnetically recyclable dye removal, ACS Sustainable Chemistry & Engineering, 6 (2017) 1279-1288 https://doi.org/10.1021/acssuschemeng.7b03635.[8] Sun Chao, Yang Sheng-Tao, Gao Zhenjie, Yang Shengnan, Yilihamu Ailimire, Ma Qiang, Zhao Ru-Song, Xue Fumin, Fe3O4/TiO2/reduced graphene oxide composites as highly efficient Fenton-like catalyst for the decoloration of methylene blue, Materials Chemistry and Physics, 223 (2019) 751-757 https://doi.org/ 10.1016/j.matchemphys.2018.11.056.[9] Guo Hui, Ma Xinfeng, Wang Chubei, Zhou Jianwei, Huang Jianxin, Wang Zijin, Sulfhydryl-Functionalized Reduced Graphene Oxide and Adsorption of Methylene Blue, Environmental Engineering Science, 36 (2019) 81-89 https://doi. org/10.1089/ees.2018.0157.[10] Zhao Lianqin, Yang Sheng-Tao, Feng Shicheng, Ma Qiang, Peng Xiaoling, Wu Deyi, Preparation and application of carboxylated graphene oxide sponge in dye removal, International journal of environmental research and public health, 14 (2017) 1301 https://doi.org/10.3390/ijerph14111301.[11] Yu Dandan, Wang Hua, Yang Jie, Niu Zhiqiang, Lu Huiting, Yang Yun, Cheng Liwei, Guo Lin, Dye wastewater cleanup by graphene composite paper for tailorable supercapacitors, ACS applied materials & interfaces, 9 (2017) 21298-21306 https://doi.org/10.1021/acsami.7b05318.[12] Wang Hou, Yuan Xingzhong, Wu Yan, Huang Huajun, Peng Xin, Zeng Guangming, Zhong Hua, Liang Jie, Ren MiaoMiao, Graphene-based materials: fabrication, characterization and application for the decontamination of wastewater and wastegas and hydrogen storage/generation, Advances in Colloid and Interface Science, 195 (2013) 19-40 https://doi. org/10.1016/j.cis.2013.03.009.[13] Marcano Daniela C, Kosynkin Dmitry V, Berlin Jacob M, Sinitskii Alexander, Sun Zhengzong, Slesarev Alexander, Alemany Lawrence B, Lu Wei, Tour James M, Improved synthesis of graphene oxide, ACS nano, 4 (2010) 4806-4814 https://doi.org/10.1021/nn1006368.[14] Zhang Jiali, Yang Haijun, Shen Guangxia, Cheng Ping, Zhang Jingyan, Guo Shouwu, Reduction of graphene oxide via L-ascorbic acid, Chemical Communications, 46 (2010) 1112-1114 http://doi. org/10.1039/B917705A [15] Gong Ming, Zhou Wu, Tsai Mon-Che, Zhou Jigang, Guan Mingyun, Lin Meng-Chang, Zhang Bo, Hu Yongfeng, Wang Di-Yan, Yang Jiang, Nanoscale nickel oxide/nickel heterostructures for active hydrogen evolution electrocatalysis, Nature communications, 5 (2014) 4695 https:// doi.org/10.1038/ncomms5695.[16] Wu Zhong-Shuai, Yang Shubin, Sun Yi, Parvez Khaled, Feng Xinliang, Müllen Klaus, 3D nitrogen-doped graphene aerogel-supported Fe3O4 nanoparticles as efficient electrocatalysts for the oxygen reduction reaction, Journal of the American Chemical Society, 134 (2012) 9082-9085 https://doi.org/10.1021/ja3030565.[17] Nguyen Son Truong, Nguyen Hoa Tien, Rinaldi Ali, Nguyen Nam Van, Fan Zeng, Duong Hai Minh, Morphology control and thermal stability of binderless-graphene aerogels from graphite for energy storage applications, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 414 (2012) 352-358 https://doi.org/ 10.1016/j.colsurfa.2012.08.048.[18] Deng Yang, Englehardt James D, Treatment of landfill leachate by the Fenton process, Water research, 40 (2006) 3683-3694 https://doi.org/ 10.1016/j.watres.2006.08.009.

In this issue of our journal, there are three articles reporting on tuberculosis, a disease which has historically been a big problem in our country – much longer than the current COVID-19 pandemic.It cannot be denied that COVID-19 is a big problem right now and should indeed be a priority. As of October 24, 2020,the DOH reports that there have been 367,819 cases of COVID-19 from the time it began monitoring the numbers some nearly nine months ago.1The effect of COVID-19 goes beyond these number of cases, as many of them have already died.However, against this alarming situation, even more concern lurks underneath. Just 10 days previously, the WHO released its 2020 Global Tuberculosis Report.2Among other things, prominent mention in the 2020 Report is the threat that theCOVID-19 pandemic can reverse the gains made in TB control over recent years in many countries, including the Philippines.In 2019, prior to the COVID-19 pandemic, the Philippines is reported to rank fourth in terms of the number of TB cases,contributing 6% of the total global burden of TB.3 Computing this on a per capita basis paints an even darker picture: the Philippines has 554 TB cases per 100,000 population, exceeded worldwide only by Lesotho, a small country in Southern Africa with a population of just around 2% that of the Philippines.4Identifying new TB cases is a key strategy in TB control. It is an important step in identifying and initiating treatmentfor those who need it. However, gaps in estimated incidence and notifications have long been a problem in the Philippines.2,3And with the COVID-19 pandemic, this has now become bigger. The 2020 WHO Report says that there has been a dropof 50 to 75% in the monthly notifications for the April to June period compared to January 2020 in the Philippines. Sucha trend – reported in other countries as well – is attributed to under-reporting of new TB cases during this COVID-19pandemic.5-13 The sudden drop over a few months cannot be due to any sudden improvement of TB control but more to the challenges that the pandemic has had on the TB control programs. In many TB high burden but low-income countries like the Philippines, reallocation of human, financial and other resources from TB to the COVID-19 response is happening. For example, GeneXpert™ machines are being diverted for use in COVID-19 testing.14 Staff in national TB programs as well as healthcare frontliners are being assigned to COVID-19 related duties. Similar to other countries, community lockdowns, patient concerns on getting infected, lack of public transportation, and loss of jobs and its attendant financial consequences, among others, are also serious considerations limiting access to TB diagnosis and treatment in the Philippines.15Any benefit from social distancing and wearing of face masks to reduce TB transmission are likely outweighed by health service disruption.16 As is the case with other patient co-morbidities, the interaction between COVID-19 and tuberculosis have also been looked into. However, current data do not allow any meaningful conclusions.14,17 Because of similarities in presentation symptoms such as fever, cough and difficulty of breathing, the recognition of tuberculosis may also be confused with COVID-19.18,19All of these are predicted to further worsen TB incidence due to increased transmission and along with greater diseaseseverity will have a larger negative effect on GDP per capita, undernutrition and catastrophic costs to families.2According to the model presented in the 2020 Global TB Report, assuming a more conservative 50% decrease in case detection over a six-month period could result in 700,000 excess deaths due to TB, globally.2The economic burden of additional cases has also been estimated for other countries and is quite substantial.20In an article published in this issue of our journal, drug resistance is identified as the biggest risk for unsuccessfultreatment outcomes in patients with tuberculosis.21 There are already increasing RR/MDR TB cases in the country based on the results of the 2016 National TB Prevalence Survey and other data.2,4,22 Previous unsuccessful treatment continues to be a big driver in the development of this drug resistance; and unsurprisingly, we now see that drug resistance in turn further drives even more unsuccessful TB treatment.In the latest WHO country profile report, RR/MDR TB incidence is estimated at 3.8% overall; but shoots up to 28%in previously treated cases.23 Most importantly, success of treatment was reported in only 58% of RR/MDR TB cases started on second-line drugs. As MDR-TB becomes more prevalent, and person-to-person transmission becomes more common, we may soon end up with MDR-TB as a major initial presentation of TB in our country. This is definitely undesirable as treatment of MDR-TB requires significantly more financial resources compared to DS-TB and can further strain the already limited resources allocated for TB control in our country. With the big challenges we face with the COVID-19 pandemic and the resulting effect it presents to ongoing TB control,it is reasonable to fear that we will have more unsuccessful treatment of TB in the country. Even as this potentially increases the number of TB cases in general, the even greater threat of further increasing MDR-TB should make us even more concerned.We cannot afford to lose focus and momentum in our efforts to control TB. Others have in fact stated that the currentpandemic may actually be a good opportunity to evaluate and if needed, to revise some of the programs we have in TBcontrol.24,25 The WHO has also made some recommendations which we can hopefully follow as we maintain our vigilance on TB control during this pandemic.26The 2020 WHO Global Tuberculosis Report highlights many of the gains we have made in the Philippines. Hopefully,this COVID-19 pandemic will not push it back. Joven Q. Tanchuco, MD, MHAEditor-in-ChiefActa Medica Philippina REFERENCES1. COVID 19 Case Tracker. DOH COVID 19. Case Bulletin # 224[Internet]. [cited 2020 Oct 25]. Available from: https://www.doh.gov.ph/covid-19/case-tracker2. Global tuberculosis report 2020. Geneva: World Health Organization.License: CC BY-NC-SA 3.0 IGO [Internet]. 2020 [cited 2020 Oct25]. Available from: https://www.who.int/tb/publications/global_report/en/3. Global tuberculosis report 2019. Geneva: World Health Organization;License: CC BY-NC-SA 3.0 IGO.4. Tanchuco JQ. Risk factors, molecular mechanisms and testing of drugresistance in Mycobacterium tuberculosis: Focus on the Philippines.Philipp J Intern Med. 2020; 58(3):72-105.5. Jain VK, Iyengar KP, Samy DA, Vaishya R. Tuberculosis in the eraof COVID-19 in India. Diabetes Metab Syndr. 2020 Sep-Oct;14(5):1439-43. doi: 10.1016/j.dsx.2020.07.034.6. Amimo F, Lambert B, Magit A. What does the COVID-19 pandemicmean for HIV, tuberculosis, and malaria control? Trop Med Health.2020; 48:32. https://doi.org/10.1186/s41182-020-00219-67. Ong CWM, Migliori GB, Raviglione M, Mac Gregor-Skinner G,Sotgiu G, Alffenaar J, et al. Epidemic and pandemic viral infections:impact on tuberculosis and the lung. Eur Respir J. 2020; 56(4):2001727.https://doi.org/10.1183/13993003.01727-20208. Fei H, Yinyin X, Hui C, Ni W, Xin D, Wei C, et al. The impact ofthe COVID-19 epidemic on tuberculosis control in China. The LancetRegional Health – Western Pacific. 2020; 3:100032 https://doi.org/10.1016/j.lanwpc.2020.1000329. Komiya K, Yamasue M, Takahashi O, Hiramatsu K, Kadota J, KatoS. The COVID-19 pandemic and the true incidence of Tuberculosisin Japan. J Infect. 2020; 81(3):e24–e25. https://doi.org/10.1016/j.jinf.2020.07.00410. Togun T, Kampmann B, Stoker NG, Lipman M. Anticipating theimpact of the COVID-19 pandemic on TB patients and TB controlprogrammes. Ann Clin Microbiol Antimicrob. 2020; 19(1):21.https://doi.org/10.1186/s12941-020-00363-111. Ribeiro VST, Telles JP, Tuon FF. Concerns about COVID-19 andtuberculosis in Brazil: Social and public health impacts. EnfermInfecc Microbiol Clin. 2020; S0213-005X(20)30278-0. https://doi.org/10.1016/j.eimc.2020.08.01312. Alene KA, Wangdi K, Clements ACA. Impact of the COVID-19Pandemic on Tuberculosis Control: An Overview. Trop Med InfectDis. 2020; 5(3):123. https://doi.org/10.3390/tropicalmed503012313. 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Others have in fact stated that the currentpandemic may actually be a good opportunity to evaluate and if needed, to revise some of the programs we have in TBcontrol.24,25 The WHO has also made some recommendations which we can hopefully follow as we maintain our vigilanceon TB control during this pandemic.26The 2020 WHO Global Tuberculosis Report highlights many of the gains we have made in the Philippines. Hopefully,this COVID-19 pandemic will not push it back.15. Adepoju P. Tuberculosis and HIV responses threatened byCOVID-19. Lancet HIV. 2020; 7(5):e319-e320. doi: 10.1016/S2352-3018(20)30109-0.16. McQuaid CF, McCreesh N, Read JM, Sumner T, Houben RMGJ,White RG, et al. The potential impact of COVID-19-relateddisruption on tuberculosis burden. Eur Respir J. 2020; 56(2):2001718.https://doi.org/10.1183/13993003.01718-202017. Crisan-Dabija R, Grigorescu C, Pavel CA, Artene B, Popa IV,Cernomaz A, et al. Tuberculosis and COVID-19: Lessons from thepast viral outbreaks and possible future outcomes. Can Respir J. 2020;2020:1401053. doi: 10.1155/2020/1401053.18. Bandyopadhyay A, Palepu S, Bandyopadhyay K, Handu S. COVID-19and tuberculosis co-infection: a neglected paradigm. MonaldiArch Chest Dis. 2020; 90(3). doi: 10.4081/monaldi.2020.143719. Wingfield T, Cuevas LE, MacPherson P, Millington KA, Squire SB.Tackling two pandemics: a plea on World Tuberculosis Day. LancetRespir Med. 2020; 8(6):536-8 https://doi.org/10.1016/S2213-2600(20)30151-X20. Reid MJA, Silva S, Arinaminpathy N, Goosby E. Building atuberculosis-free world while responding to the COVID-19 pandemic.Lancet. 2020; 396(10259):1312-3. https://doi.org/10.1016/S0140-6736(20)32138-321. Macatangay IOD, Liao SAS, Dadural JJA, Gagui FJS, Galas AJA, SanAntonio RDFA, et al. Factors Associated with Treatment Outcomeof Patients with Pulmonary Tuberculosis in the Philippines, 2015 to2016. Acta Med Philipp. 2020; 54(5):604-1122. DOH. National Tuberculosis Prevalence Survey 2016 Philippines[Internet]. 2018 [cited 2020 Oct 25]. Available from: http://www.ntp.doh.gov.ph/downloads/publications/Philippines_2016%20National%20TB%20Prevalence%20Survey_March2018.pdf23. WHO. 2020 Global Tuberculosis Report [Internet]. [cited 2020Oct 25]. Available from: https://worldhealthorg.shinyapps.io/tb_profiles/?_inputs_&lan=%22EN%22&iso2=%22PH%2224. Keene C, Mohr-Holland E, Cassidy T, Scott V, Nelson A, Furin J, et al.How COVID-19 could benefit tuberculosis and HIV services in SouthAfrica. Lancet Respir Med. 2020; 8(9):844–6. https://doi.org/10.1016/S2213-2600(20)30311-825. Manyazewal T, Woldeamanuel Y, Blumberg HM, Fekadu A,Marconi VC. The fight to end tuberculosis must not be forgotten inthe COVID-19 outbreak. Nat Med. 2020; 26(6):811–2. https://doi.org/10.1038/s41591-020-0917-126. WHO. Updated WHO Information Note: Ensuring the continuityof TB services during the COVID-19 pandemic [Internet]. 2020[cited 2020 Oct 25]. Available from: https://www.who.int/docs/default-source/documents/tuberculosis/infonote-tb-covid-19.pdf?sfvrsn=b5985459_18